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https://www.readbyqxmd.com/read/29228154/comparative-transcriptomic-analysis-of-human-placentae-at-term-and-preterm-delivery
#1
Alison G Paquette, Heather M Brockway, Nathan D Price, Louis J Muglia
Purpose: Preterm birth affects 1 out of every 10 infants in the United States, resulting in substantial neonatal morbidity and mortality. Currently, there are few predictive markers and few treatment options to prevent preterm birth. A healthy, functioning placenta is essential to positive pregnancy outcomes. Previous studies have suggested that placental pathology may play a role in preterm birth etiology. Therefore, we tested the hypothesis that preterm placentae may exhibit unique transcriptomic signatures compared to term samples reflective of their abnormal biology leading to this adverse outcome...
December 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29228105/metformin-attenuates-susceptibility-to-inflammation-induced-preterm-birth-in-mice-with-higher-endocannabinoid-levels
#2
Xiaofei Sun, Alexandra Tavenier, Wenbo Deng, Emma Leishman, Heather B Bradshaw, Sudhansu K Dey
Premature decidual senescence is a contributing factor to preterm birth. Fatty acid amide hydrolase mutant females (Faah-/-) with higher endocannabinoid levels are also more susceptible to preterm birth upon lipopolysaccharide (LPS) challenge due to enhanced decidual senescence; this is associated with MAPK p38 activation. Previous studies have shown that mammalian target of rapamycin complex 1 (mTORC1) contributes to decidual senescence and promotes the incidence of preterm birth. In the present study, we sought to attenuate premature decidual aging in Faah-/- females by targeting mTORC1 and p38 signaling pathways...
December 5, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29227903/sensory-processing-difficulties-in-school-age-children-born-very-preterm-an-exploratory-study
#3
Tinka Bröring, Marsh Königs, Kim J Oostrom, Harrie N Lafeber, Anniek Brugman, Jaap Oosterlaan
BACKGROUND: Very preterm birth has a detrimental impact on the developing brain, including widespread white matter brain abnormalities that threaten efficient sensory processing. Yet, sensory processing difficulties in very preterm children are scarcely studied, especially at school age. AIMS: To investigate somatosensory registration, multisensory integration and sensory modulation. PARTICIPANTS: 57 very preterm school-age children (mean age=9...
December 8, 2017: Early Human Development
https://www.readbyqxmd.com/read/29226760/the-diagnostic-performance-of-the-beta-glucan-assay-in-the-detection-of-intra-amniotic-infection-with-candida-species
#4
Percy Pacora, Roberto Romero, Offer Erez, Eli Maymon, Bogdan Panaitescu, Juan Pedro Kusanovic, Adi L Tarca, Chaur-Dong Hsu, Sonia S Hassan
INTRODUCTION: A bioassay based on the detection of beta-glucan, a constituent of the cell wall of fungi, has been successfully used to diagnose fungal infections in a variety of biological fluids but not yet in the amniotic fluid. OBJECTIVE: To determine the diagnostic performance of a beta-glucan bioassay in the detection of Candida species in the amniotic fluid. METHODS: The study population comprised women who had a singleton pregnancy without congenital or chromosomal abnormalities, who experienced preterm labor or preterm prelabor rupture of the fetal membranes, and who underwent transabdominal amniocentesis for clinical indications...
December 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29226752/influence-of-time-of-delivery-on-risk-of-adverse-neonatal-outcome-in-different-size-of-delivery-units-a-retrospective-cohort-study-in-finland
#5
Elina Karalis, Mika Gissler, Anna-Maija Tapper, Veli-Matti Ulander
PURPOSE: To evaluate the impact of time of birth on adverse neonatal outcome in singleton term hospital births. MATERIALS AND METHODS: Medical Birth Register Data in Finland from 2005 to 2009. Study population was all hospital births (n = 263 901), excluding multiple pregnancies, preterm births < 37 weeks, major congenital anomalies or birth defects, and antepartum stillbirths. Main outcome measures were either 1-minute Apgar score 0-3, 5-minute Apgar score 0-6, or umbilical artery pH < 7...
December 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29226278/effects-of-multiple-freeze-thaw-cycles-on-measurements-of-potential-novel-biomarkers-associated-with-adverse-pregnancy-outcomes
#6
Sandra L Rebholz, John T Melchior, Jeffrey A Welge, Alan T Remaley, W Sean Davidson, Laura A Woollett
World-wide, millions of women enter preterm labor or have small newborns. Effective biomarkers are needed to identify women at risk for these adverse outcomes. A time and cost effective way to examine any potentially new biomarkers in samples collected during prior studies or trials that had been assayed for other metabolites would be highly useful. Thus, the current study aimed to determine if samples that had been previously thawed and re-frozen could be re-assayed for novel biomarkers, those being lipoprotein composition (sizing, proteome, lipids) and combined cholesterol and cytokine concentrations...
2017: Journal of Clinical and Laboratory Medicine
https://www.readbyqxmd.com/read/29224936/bilateral-pulmonary-sequestration-in-a-preterm-infant
#7
Fabian von Scheidt, Andreas Eicken, Tobias Wowra, Horst Brunner, Christian Apitz
No abstract text is available yet for this article.
December 7, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29224772/resolution-of-vocal-fold-immobility-in-preterm-infants
#8
Jad Jabbour, Thomas Robey
INTRODUCTION: Vocal fold immobility (VFI) is an important sequela of preterm birth due to patent ductus arteriosus (PDA) ligation and invasive ventilation. A minority of these patients experience VFI resolution. The purpose of this study is to determine factors associated with VFI resolution in preterm infants. METHODS: This is a case control study of preterm (<37 weeks gestation) infants admitted to a metropolitan Level IV neonatal intensive care unit from 2006 to 2012...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29224680/pregnancy-in-systemic-lupus-erythematosus-and-antiphospholipid-syndrome
#9
REVIEW
Rebecca Fischer-Betz, Christof Specker
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with a high prevalence in females of childbearing age. Pregnancy in SLE nowadays has favorable outcomes for the majority of women. However, flares of disease activity, preeclampsia, fetal loss, and preterm birth are well-known risks in such pregnancies. Anti-SS-A(Ro)/SS-B(La) antibodies put fetuses at risk for congenital heart block and neonatal lupus. Several risk factors for adverse pregnancy outcomes have been identified. Women with antiphospholipid antibodies or antiphospholipid syndrome and lupus nephritis represent a group with high risk for obstetric complications...
June 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29224252/are-inhaled-steroids-safe-and-effective-for-prevention-or-treatment-of-bronchopulmonary-dysplasia
#10
Eric S Shinwell
Bronchopulmonary Dysplasia (BPD) represents a major threat to the short and long-term health and development of very preterm infants. Unfortunately, despite much study and progress in neonatology in recent years and some modest improvements in survival, both the incidence and severity of BPD remain frustratingly stable (1). This article is protected by copyright. All rights reserved.
December 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29224001/dental-caries-and-developmental-defects-of-enamel-in-the-primary-dentition-of-preterm-infants-case-control-observational-study
#11
Ina Manuela Schüler, Stefanie Haberstroh, Kristin Dawczynski, Thomas Lehmann, Roswitha Heinrich-Weltzien
AIM: Assessment of dental health in the primary dentition of preterm infants (PTI) including investigation of mother- and infant-related risk factors in a case-control study design. MATERIAL AND METHODS: One hundred twenty-eight infants aged 3-4 years were included. Sixty-four PTI (27 males) were randomly selected from the preterm registry of the Jena University Hospital. As a control group served 64 full-term infants (FTI) recruited from the Department of Paediatric Dentistry, matched for age and sex...
December 9, 2017: Caries Research
https://www.readbyqxmd.com/read/29223898/exposure-to-low-concentrations-of-air-pollutants-and-adverse-birth-outcomes-in-brisbane-australia-2003-2013
#12
Gongbo Chen, Yuming Guo, Michael J Abramson, Gail Williams, Shanshan Li
BACKGROUND: It's unclear whether exposures to low-level air pollution have adverse effects on birth outcomes, and which trimester-specific pregnant exposure is sensitive. OBJECTIVES: To investigate the effects of maternal exposure during each trimester and the whole pregnancy to particles with aerodynamic diameter<2.5μm (PM2.5), sulfur dioxide (SO2), nitrogen dioxide (NO2), and ozone (O3) on preterm birth (PTB) and low birth weight (LBW). METHODS: Daily data on birth records, air quality, and weather conditions were collected in Brisbane, Australia during 2003-2013...
December 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223489/platelet-mass-index-can-be-a-reliable-marker-in-predicting-the-prognosis-of-retinopathy-of-prematurity-in-very-preterm-infants
#13
Levent Korkmaz, Osman Baştuğ, Ahmet Özdemir, Sabriye Korkut, Çağatay Karaca, Mustafa Ali Akın, Mehmet Adnan Öztürk
BACKGROUND: Retinopathy of prematurity (ROP) is a proliferative vitreoretinopathy resulting from vascular defect of the retina. The present study evaluates platelets, which are involved in VEGF storage, transport and release, and their functions with regard to the prognosis of the disease. The objective was to suggest a simple minimal invasive method that will facilitate the management of the disease and help clinicians in predicting the prognosis. METHODS: In this single center, retrospective, case-control study, we included a control group consisting of very preterm newborns (n = 83) at risk of ROP and a laser photocoagulation group including infants (n = 63) who received laser therapy during their follow-up examinations...
November 13, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29223461/antenatal-consultations-at-extreme-prematurity-a-systematic-review-of-parent-communication-needs
#14
Ashraf Kharrat, Gregory P Moore, Stéphanie Beckett, Stuart G Nicholls, Margaret Sampson, Thierry Daboval
OBJECTIVE: To synthesize and describe parental expectations on how healthcare professionals should interact with them during a peripartum, antenatal consultation for extremely preterm infants. STUDY DESIGN: For this systematic literature review with textual narrative synthesis, we included studies that explored parental perspectives regarding the antenatal consultation for an extremely preterm infant. Electronic searches of Medline, CINAHL, PsycInfo, and Embase were conducted, along with a search of the grey literature...
December 6, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29222766/electrical-velocimetry-for-non-invasive-monitoring-of-the-closure-of-the-ductus-arteriosus-in-preterm-infants
#15
Ana Rodríguez Sánchez de la Blanca, M Sánchez Luna, N González Pacheco, M Arriaga Redondo, N Navarro Patiño
Closure of a patent ductus arteriosus (PDA) in preterm infants modifies cardiac output and induces adaptive changes in the hemodynamic situation. The present study aims to analyze those changes, through a non-invasive cardiac output monitor based on blood electrical velocimetry, in preterm babies. A prospective observational study of preterm infants with a gestational age of less than 28 weeks, and a hemodynamic significant PDA, requires intravenous ibuprofen or surgical closure. All patients were monitored with electrical velocimetry before treatment and through the following 72 h...
December 8, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29222398/cerebral-palsy-in-extremely-preterm-infants
#16
Maria Hafström, Karin Källén, Fredrik Serenius, Karel Maršál, Eva Rehn, Helen Drake, Ulrika Ådén, Aijaz Farooqi, Kristina Thorngren-Jerneck, Bo Strömberg
BACKGROUND AND OBJECTIVES: The risk of cerebral palsy (CP) is high in preterm infants and is often accompanied by additional neurodevelopmental comorbidities. The present study describes lifetime prevalence of CP in a population-based prospective cohort of children born extremely preterm, including the type and severity of CP and other comorbidities (ie, developmental delay and/or cognitive impairment, neurobehavioral morbidity, epilepsy, vision and hearing impairments), and overall severity of disability...
December 8, 2017: Pediatrics
https://www.readbyqxmd.com/read/29222137/benefits-of-probiotics-in-preterm-neonates-in-low-income-and-medium-income-countries-a-systematic-review-of-randomised-controlled-trials
#17
Girish Deshpande, Gayatri Jape, Shripada Rao, Sanjay Patole
OBJECTIVE: Although there is an overall reduction in underfive mortality rate, the progress in reducing neonatal mortality rate has been very slow. Over the last 20 years, preterm births have steadily increased in low-income and medium-income countries (LMICs) particularly in sub-Saharan Africa and South Asia. Preterm birth is associated with increased mortality and morbidity, particularly in LMICs. Based on systematic reviews of randomised controlled trials (RCTs), many neonatal units in high-income countries have adopted probiotics as standard of care for preterm neonates...
December 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/29221766/screening-for-fetal-growth-restriction-and-placental-insufficiency
#18
REVIEW
Melanie C Audette, John C Kingdom
Fetal growth restriction (FGR) continues to be a leading cause of preventable stillbirth and poor neurodevelopmental outcomes in offspring, and furthermore is strongly associated with the obstetrical complications of iatrogenic preterm birth and pre-eclampsia. The terms small for gestational age (SGA) and FGR have, for too long, been considered equivalent and therefore used interchangeably. However, the delivery of improved clinical outcomes requires that clinicians effectively distinguish fetuses that are pathologically growth-restricted from those that are constitutively small...
December 5, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29218490/fathers-count-the-impact-of-paternal-risk-factors-on-birth-outcomes
#19
Ying Meng, Susan W Groth
Objective To determine the contribution of paternal factors to the risk of adverse birth outcomes. Methods This is a retrospective cross-sectional analysis using birth certificate data from 2004 to 2015 retrieved from the Finger Lakes Regional Perinatal Data System. Primiparous women with singleton pregnancies were analyzed in the study. Two multivariate logistic regression models were conducted to assess potential paternal risk factors including age, race/ethnicity, and education on four birth outcomes, including preterm birth (PTB), low birthweight (LBW), high birthweight (HBW), and small for gestational age (SGA)...
December 7, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29218481/concepts-for-a-therapeutic-prolongation-of-nephrogenesis-in-preterm-and-low-birth-weight-babies-must-correspond-to-structural-functional-properties-in-the-nephrogenic-zone
#20
REVIEW
Will W Minuth
Numerous investigations are dealing with anlage of the mammalian kidney and primary development of nephrons. However, only few information is available about the last steps in kidney development leading at birth to a downregulation of morphogen activity in the nephrogenic zone and to a loss of stem cell niches aligned beyond the organ capsule. Surprisingly, these natural changes in the developmental program display similarities to processes occurring in the kidneys of preterm and low-birth-weight babies. Although those babies are born at a time with a principally intact nephrogenic zone and active niches, a high proportion of them suffers on impairment of nephrogenesis resulting in oligonephropathy, formation of atypical glomeruli, and immaturity of parenchyma...
December 7, 2017: Molecular and Cellular Pediatrics
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