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https://www.readbyqxmd.com/read/29793166/renoprotective-effect-of-the-isoflavonoid-biochanin-a-against-cisplatin-induced-acute-kidney-injury-in-mice-effect-on-inflammatory-burden-and-p53-apoptosis
#1
Faiha A Suliman, Dina M Khodeer, Afaf Ibrahiem, Eman T Mehanna, Mohamed K El-Kherbetawy, Hala M F Mohammad, Sawsan A Zaitone, Yasser M Moustafa
Cisplatin is a potent widely-used chemotherapeutics; however, its clinical use is associated with nephrotoxicity. Renoprotective approaches are being discovered to halt the tubular cell death due to inflammatory and apoptotic burdens. In the present study, the renoprotective effects of different doses of biochanin A (10, 20 or 40 mg/kg) in mice treated with a single injection of cisplatin (10 mg/kg) were reported. Cisplatin administration resulted in marked increases in serum creatinine and blood urea nitrogen...
May 21, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29792933/role-of-neuronal-nitric-oxide-synthase-in-slowly-progressive-dopaminergic-neurodegeneration-in-the-zitter-rat
#2
Ayuka Ehara, Kazuhiko Nakadate, Hiroyuki Sugimoto, Kanji Yoshimoto, Shuichi Ueda
Neuronal nitric oxide synthase (nNOS) is involved in nigrostriatal dopaminergic (DA) neurodegeneration. However, little is known about the distribution patterns and functions of nNOS in slowly progressive DA neurodegeneration. Here we describe the spatiotemporal change in nNOS expression over the course of neurodegeneration and the effect of short- or long-term treatment with the nNOS inhibitor, 7-nitroindazole (7-NI), in zitter (zi/zi) rats. In the substantia nigra pars compacta (SNc), nNOS expression was significantly increased with progression of neurodegeneration...
May 21, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29792890/the-visual-cortex-and-visual-cognition-in-huntington-s-disease-an-overview-of-current-literature
#3
REVIEW
Emma M Coppen, Jeroen van der Grond, Ellen P Hart, Egbert A J F Lakke, Raymund A C Roos
The processing of visual stimuli from retina to higher cortical areas has been extensively studied in the human brain. In Huntington's disease (HD), an inherited neurodegenerative disorder, it is suggested that visual processing deficits are present in addition to more characteristic signs such as motor disturbances, cognitive dysfunction, and behavioral changes. Visual deficits are clinically important because they influence overall cognitive performance and have implications for daily functioning. The aim of this review is to summarize current literature on clinical visual deficits, visual cognitive impairment, and underlying visual cortical changes in HD patients...
May 21, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29792731/apr3-modulates-oxidative-stress-and-mitochondrial-function-in-arpe-19-cells
#4
Yuan Li, Xuan Zou, Jing Gao, Ke Cao, Zhihui Feng, Jiankang Liu
Impairment of retinal pigment epithelial (RPE) cells is considered a key contributor to the development of age-related macular degeneration. Apoptosis-related protein 3 (APR3) was recently discovered after treatment with all- trans retinoic acid, a pivotal molecule in RPE cells. However, the function of APR3 remains poorly understood. In the present study, we found that APR3 could interact with nuclear factor (erythroid-derived 2)-like 2, which is a regulator of phase II enzymes, and that knockdown of APR3 promoted nuclear factor (erythroid-derived 2)-like 2 nuclear translocation and activated expression of phase II enzymes, which was accompanied by improved redox status and mitochondrial activity...
May 24, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29791166/intervalley-scattering-of-interlayer-excitons-in-a-mos-2-mose-2-mos-2-heterostructure-in-high-magnetic-field
#5
Alessandro Surrente, Łukasz Klopotowski, Nan Zhang, Michal Baranowski, Anatolie Mitioglu, Mariana V Ballottin, Peter C M Christianen, Dumitru Dumcenco, Yen-Cheng Kung, Duncan K Maude, Andras Kis, Paulina Plochocka
Degenerate extrema in the energy dispersion of charge carriers in solids, also referred to as valleys, can be regarded as a binary quantum degree of freedom, which can potentially be used to implement valleytronic concepts in van der Waals heterostructures based on transition metal dichalcogenides. Using magneto-photoluminescence spectroscopy, we achieve a deeper insight into the valley polarization and depolarization mechanisms of interlayer excitons formed across a MoS2 /MoSe2 /MoS2 heterostructure. We account for the non-trivial behavior of the valley polarization as a function of the magnetic field by considering the interplay between exchange interaction and phonon mediated intervalley scattering in a system consisting of Zeeman-split energy levels...
May 23, 2018: Nano Letters
https://www.readbyqxmd.com/read/29791059/the-use-of-high-resolution-colonic-manometry-to-establish-etiology-and-direct-treatment-in-patients-with-constipation-case-series-with-correlation-to-histology
#6
Yuwei Li, Jiying Cong, Fei Fei, Zhao Zhang, Yongjun Yu, Chen Xu, Xipeng Zhang, Shiwu Zhang
BACKGROUND AND AIM: Different clinical treatments are available to treat patients with constipation. We aimed to study the etiology and direct treatment in a case series of patients with constipation by the use of high-resolution colonic manometry (HRCM). METHODS: HRCM was used to record the colorectal peristaltic contractions of the entire colon in patients. Based on the results of HRCM, 151 patients with constipation were classified into groups and received different clinical treatment such as a total or subtotal colectomy, local excision, or conservative treatment...
May 23, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29790721/techniques-and-outcomes-of-secondary-endovascular-repair-for-post-dissection-taa-taaa
#7
Pablo Marques De Marino, Kyriakos Oikonomou, Eric L Verhoeven, Athanasios Katsargyris
Post-dissection aortic aneurysms (PDAA) affect 20-40% of patients with aortic dissection. Open repair remains the first line therapy of PDAA, but is still associated with high mortality and morbidity rates. Endovascular repair is increasingly being used as a less invasive treatment option. Thoracic endovascular aneurysm repair (TEVAR) covering only the proximal entry tear has proven to be insufficient in most patients with chronic PDAA and has a limited role only for PDAA with distal sealing zone in the thoracic aorta...
May 23, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29790691/the-protective-effect-of-gingko-biloba-in-a-rat-model-of-ovarian-ischemia-reperfusion-injury-improvement-in-histological-and-biochemical-parameters
#8
Nuri Yildirim, Deniz Simsek, Semir Kose, Alkim Gulsah Sahingoz Yildirim, Cagri Guven, Gurkan Yigitturk, Oytun Erbas
BACKGROUND: Ovarian torsion is one of the most common gynecological emergencies, which especially affects women of reproductive age. OBJECTIVES: We aimed to evaluate the effect of Ginkgo biloba (GB) supplementation in ovarian ischemia/ reperfusion injury in an experimental torsion/de-torsion rat model. MATERIAL AND METHODS: This study was carried out in the Ege University Faculty of Medicine in Izmir, Turkey. Thirty mature female Sprague-Dawley albino rats were randomly divided into 5 groups: in Group 1 (control), the abdominal wall was only opened and closed; in the torsion group (Group 2), ischemia was induced for 3 h, using atraumatic vascular clips to create a torsion model; in the torsion/GB group (Group 3), the rats were given 80 mg/kg (oral gavage) of GB 30 min before torsion was induced and the torsion model was formed; in the torsion/de-torsion group (Group 4), the rats underwent 3 h of ischemia and then the vascular clips were removed and reperfusion took place for 3 h; in the torsion/de-torsion/GB group (Group 5), the rats underwent 3 h of ischemia followed by GB (oral gavage) 30 min prior to a 3-h reperfusion period...
May 16, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790206/efficacy-and-safety-of-transcatheter-valve-in-valve-replacement-for-mitroflow-bioprosthetic-valve-dysfunction
#9
Victor X Mosquera, Miguel González-Barbeito, Alberto Bouzas-Mosquera, José M Herrera-Noreña, Carlos Velasco, Jorge Salgado-Fernández, Ramón Calviño-Santos, Nicolás Vázquez-González, José M Vázquez-Rodríguez, José J Cuenca-Castillo
OBJECTIVES: Bioprostheses with pericardial leaflets mounted externally on the stent pose a high risk for valve-in-valve (ViV) procedures. This study analyzed the efficacy and safety of ViV procedures for treating structural valve deterioration (SVD) in Mitroflow bioprostheses. METHODS: Between January 2012 and August 2017, 11 patients (mean age 80.3 ± 5.6 years) were treated for SVD of Mitroflow bioprostheses with transcatheter ViV procedures (six transapical [TA] and five transfemoral [TF]) using balloon expandable bioprostheses...
May 22, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29790198/the-role-of-lysosomes-and-autophagosomes-in-frontotemporal-lobar-degeneration
#10
Hamish Dc Bain, Yvonne S Davidson, Andrew C Robinson, Sarah Ryan, Sara Rollinson, Anna Richardson, Matthew Jones, Julie S Snowden, Stuart Pickering-Brown, David M A Mann
INTRODUCTION: Cell biological and genetic evidence implicates failures in degrading aggregating proteins, such as tau and TDP-43, through autophagy or lysosomal pathways in the pathogenesis of Frontotemporal Lobar degeneration (FTLD). METHODS: We investigated changes in degradative pathways in 60 patients with different pathological or genetic forms of FTLD employing immunohistochemistry for marker proteins such as Lysosomal Associated Membrane Proteins 1 (LAMP-1) and 2 (LAMP-2), Cathepsin D (CTSD) and microtubule-associated protein 1 light chain 3 alpha (LC3A)...
May 23, 2018: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29789912/meniscal-pathologies-on-mri-correlate-with-increased-bone-tracer-uptake-in-spect-ct
#11
Jan Rechsteiner, Michael T Hirschmann, Milos Dordevic, Anna L Falkowski, Enrique A Testa, Felix Amsler, Anna Hirschmann
OBJECTIVES: To assess the relationship of subchondral bone tracer uptake (BTU) on SPECT/CT and meniscal pathologies on MRI in patients with painful knees. METHODS: Twenty-five patients who had MRI and SPECT/CT within 3 months without knee surgery or grade ≥3 cartilage lesions were prospectively included. Maximum values of each subchondral femorotibial area were quantified and a ratio was calculated in relation to a femoral shaft reference region, which represented the BTU background activity...
May 22, 2018: European Radiology
https://www.readbyqxmd.com/read/29789898/-clinical-parameters-of-patients-with-neovascular-age-related-macular-degeneration-longterm-treatment-results-of-an-outpatient-clinic
#12
S Wassel, E Tsompanidi, E Tahmaz, B Hörster, R Hoerster
BACKGROUND: The clinical outcome of neovascular age-related macular degeneration (nAMD) depends on constant follow-up and consistent treatment. Data about the long-term course of intensive anti-vascular endothelial growth factor (VEGF) therapy from outpatient clinics are rare. OBJECTIVE: The aim of the study was to characterize a population of nAMD patients with long-term follow-up and intensive anti-VEGF therapy. PATIENTS AND METHODS: In a supra-regional outpatient clinic, we retrospectively identified patients who had received at least 30 intravitreal anti-VEGF injections and were followed for at least 4 years...
May 22, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29789566/transcriptome-analysis-of-the-adult-human-klinefelter-testis-and-cellularity-matched-controls-reveals-disturbed-differentiation-of-sertoli-and-leydig-cells
#13
Sofia Boeg Winge, Marlene Danner Dalgaard, Kirstine G Belling, Jacob Malte Jensen, John Erik Nielsen, Lise Aksglaede, Mikkel Heide Schierup, Søren Brunak, Niels Erik Skakkebæk, Anders Juul, Ewa Rajpert-De Meyts, Kristian Almstrup
The most common human sex chromosomal disorder is Klinefelter syndrome (KS; 47,XXY). Adult patients with KS display a diverse phenotype but are nearly always infertile, due to testicular degeneration at puberty. To identify mechanisms causing the selective destruction of the seminiferous epithelium, we performed RNA-sequencing of 24 fixed paraffin-embedded testicular tissue samples. Analysis of informative transcriptomes revealed 235 differentially expressed transcripts (DETs) in the adult KS testis showing enrichment of long non-coding RNAs, but surprisingly not of X-chromosomal transcripts...
May 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29789529/inhibiting-p38-mapk-alpha-rescues-axonal-retrograde-transport-defects-in-a-mouse-model-of-als
#14
Katherine L Gibbs, Bernadett Kalmar, Elena R Rhymes, Alexander D Fellows, Mahmood Ahmed, Paul Whiting, Ceri H Davies, Linda Greensmith, Giampietro Schiavo
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the degeneration of upper and lower motor neurons. Defects in axonal transport have been observed pre-symptomatically in the SOD1G93A mouse model of ALS, and have been proposed to play a role in motor neuron degeneration as well as in other pathologies of the nervous system, such as Alzheimer's disease and hereditary neuropathies. In this study, we screen a library of small-molecule kinase inhibitors towards the identification of pharmacological enhancers of the axonal retrograde transport of signalling endosomes, which might be used to normalise the rate of this process in diseased neurons...
May 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29789505/multilayer-black-phosphorus-near-infrared-photodetectors
#15
Chaojian Hou, Lijun Yang, Bo Li, Qihan Zhang, Yuefeng Li, Qiuyang Yue, Yang Wang, Zhan Yang, Lixin Dong
Black phosphorus (BP), owing to its distinguished properties, has become one of the most competitive candidates for photodetectors. However, there has been little attention paid on photo-response performance of multilayer BP nanoflakes with large layer thickness. In fact, multilayer BP nanoflakes with large layer thickness have greater potential from the fabrication viewpoint as well as due to the physical properties than single or few layer ones. In this report, the thickness-dependence of the intrinsic property of BP photodetectors in the dark was initially investigated...
May 23, 2018: Sensors
https://www.readbyqxmd.com/read/29789352/reporting-quality-of-randomised-controlled-trial-abstracts-on-age-related-macular-degeneration-health-care-a-cross-sectional-quantification-of-the-adherence-to-consort-abstract-reporting-recommendations
#16
Christine Baulig, Frank Krummenauer, Berit Geis, Sabrina Tulka, Stephanie Knippschild
OBJECTIVE: To assess the reporting quality of randomised controlled trial (RCT) abstracts on age-related macular degeneration (AMD) healthcare, to evaluate the adherence to the Consolidated Standards of Reporting Trials (CONSORT) statement's recommendations on minimum abstract information and to identify journal characteristics associated with abstract reporting quality. DESIGN: Cross-sectional evaluation of RCT abstracts on AMD healthcare. METHODS: A PubMed search was implemented to identify RCT abstracts on AMD healthcare published in the English language between January 2004 and December 2013...
May 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29788696/forehead-reconstruction-with-a-custom-made-threedimensional-titanium-implant-in-a-parry-romberg-syndrome-patient
#17
Jae Yoon Kim, Bok Ki Jung, Young Suk Kim, Tai Suk Roh, In Sik Yun
Parry-Romberg syndrome is a rare neurocutaneous syndrome characterized by progressive shrinkage and degeneration of the tissues usually on only one side of the face. It is usually difficult to restore the facial contour due to skin tightness. In this case report, we report a forehead reconstruction with custom-made three-dimensional (3D) titanium implant of a Parry-Romberg syndrome patient who was treated with multiple fat grafts but had limited effect. A 36-year-old man presented with hemifacial atrophy. The disease progressed from 5 to 16 years old...
May 24, 2018: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/29788411/pathogenesis-of-duck-circovirus-genotype-1-in-experimentally-infected-pekin-ducks
#18
Y-T Hong, M Kang, H-K Jang
Ducks infected with duck circovirus (DuCV) exhibit feathering disorder, growth retardation, and low body weight. The virus can induce immunosuppression and increase rates of infection caused by other pathogens. The purpose of the present study was to investigate the pathogenesis of DuCV in experimentally infected Pekin ducks. At postmortem examination, gross lesions were observed in the immune organs including bursa of Fabricius (BF), thymus, and spleen. Hemorrhage, lymphocytic depletion, necrosis, and degeneration were observed in the bursal tissues by histological examination...
May 17, 2018: Poultry Science
https://www.readbyqxmd.com/read/29788265/gene-expression-profile-in-frontal-cortex-in-sporadic-frontotemporal-lobar-degeneration-tdp
#19
Pol Andrés-Benito, Ellen Gelpi, Mónica Povedano, Gabriel Santpere, Isidro Ferrer
Molecular alterations compromising key metabolic pathways are poorly understood in sporadic frontotemporal lobar degeneration with TDP-43 pathology (sFTLD-TDP). Whole-transcriptome array, RT-qPCR validation, gel electrophoresis, and Western blotting, and mitochondrial electron transport chain (ETC) activity were comparatively examined in frontal cortex (area 8) of 16 sFTLD-TDP cases and 14 controls. Assessment of 111 genes by RT-qPCR showed deregulation of 81 genes linked to neurotransmission and synapses, neuronal architecture, cytoskeleton of axons and dendrites, vesicle trafficking, purines, mitochondria, and energy metabolism in sFTLD-TDP...
May 19, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29788038/testing-a-longitudinal-compensation-model-in-premanifest-huntington-s-disease
#20
Sarah Gregory, Jeffrey D Long, Stefan Klöppel, Adeel Razi, Elisa Scheller, Lora Minkova, Eileanoir B Johnson, Alexandra Durr, Raymund A C Roos, Blair R Leavitt, James A Mills, Julie C Stout, Rachael I Scahill, Sarah J Tabrizi, Geraint Rees
The initial stages of neurodegeneration are commonly marked by normal levels of cognitive and motor performance despite the presence of structural brain pathology. Compensation is widely assumed to account for this preserved behaviour, but despite the apparent simplicity of such a concept, it has proven incredibly difficult to demonstrate such a phenomenon and distinguish it from disease-related pathology. Recently, we developed a model of compensation whereby brain activation, behaviour and pathology, components key to understanding compensation, have specific longitudinal trajectories over three phases of progression...
May 17, 2018: Brain: a Journal of Neurology
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