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https://www.readbyqxmd.com/read/28944974/granulomatous-enteritis-in-rainbow-trout-oncorhynchus-mykiss-associated-with-soya-bean-meal-regardless-of-water-dissolved-oxygen-level
#1
P Mosberian-Tanha, T Landsverk, C M Press, L T Mydland, J W Schrama, M Øverland
This study investigated morphological changes associated with soya bean meal-induced enteritis (SBMIE) in distal intestine (DI) of rainbow trout (Oncorhynchus mykiss) fed a soya bean meal (SBM)-based diet and exposed to normoxia or hypoxia created by optimal and low water flow rates, respectively. A 28-day adaption period was followed by a 42-day challenge period where 600 fish were subjected to dietary challenge and/or hypoxia. Twelve tanks each containing 50 juvenile trout were assigned randomly in triplicate to each treatment...
September 25, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28944909/long-non%C3%A2-coding-rna-associated%C3%A2-competing-endogenous-rnas-are-induced-by-clusterin-in-retinal-pigment-epithelial-cells
#2
Zi Ye, Zhaohui Li, Shouzhi He
Age related macular degeneration is one of the most common causes of vision loss in the elderly. Long noncoding RNAs (lncRNAs) serve important roles in regulating gene expression by acting as competing endogenous RNAs (ceRNAs). However, the roles of specific lncRNAs and their associated ceRNA function induced by clusterin in cultured retinal pigment epithelial (RPE) cells remain to be fully elucidated. Based on high throughput sequencing data from RPE cells treated with or without clusterin, the present study identified differentially expressed mRNAs, lncRNAs and microRNAs (miRNAs)...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944891/thioredoxin-is-implicated-in-the-anti%C3%A2-apoptotic-effects-of-grape-seed-proanthocyanidin-extract-during-hyperglycemia
#3
Xiang Ren, Heyuan Lu, Nina Wang, Chenghong Zhang, Yunpeng Ji, Shiqi Cui, Yichen Dong, Kaiyuan Yang, Mengyi Du, Fengsheng Diao, Li Kong
Diabetic retinopathy has long been recognized as a microvascular disease, however, recent research has indicated that diabetic retinopathy may also be considered a neurodegenerative disease. The elucidation of the molecular mechanisms underlying the development of diabetic retinopathy is imperative for the development of preventive and treatment strategies for patients with diabetes. In the present study, grape seed proanthocyanidin extract (GSPE) was used to upregulate the expression of thioredoxin (Trx), in order to evaluate its potential as a novel agent for the prevention and treatment of neurodegenerative diseases, including diabetic retinopathy...
September 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944876/nutrient-deprivation-induces-apoptosis-of-nucleus-pulposus-cells-via-activation-of-the-bnip3-aif-signalling-pathway
#4
Jie Liu, Chao Yuan, Luqiao Pu, Jian Wang
Nutrient deprivation (ND)‑induced nucleus pulposus (NP) cell death serves an important role in intervertebral disc degeneration disease. However, the underlying mechanisms have yet to be thoroughly elucidated. The present study created a cell culture model under ND conditions to investigate the roles of the nutrient‑sensitive protein B‑cell lymphoma 2/adenovirus E1B 19 kDa‑interacting protein (BNIP3) and the mitochondrial pro‑death protein apoptosis‑inducing factor (AIF) in the death pathway of NP cells...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944864/halofuginone-attenuates-articular-cartilage-degeneration-by-inhibition-of-elevated-tgf%C3%A2-%C3%AE-1-signaling-in-articular-cartilage-in-a-rodent-osteoarthritis-model
#5
Wenbo Mu, Boyong Xu, Hairong Ma, Baochao Ji, Zhendong Zhang, Jiao Li, Abdusami Amat, Li Cao
Osteoarthritis (OA) is the most common degenerative condition of the weight‑bearing joints worldwide without effective medical therapy. In order to investigate whether administration of halofuginone (HF) may attenuate OA, the present study allocated 3‑month‑old male mice into Sham group, vehicle‑treated anterior cruciate ligament transection (ACLT) group and HF‑treated ACLT group. The present study determined that HF treatment reduced the expression of matrix metallopeptidase‑13 and collagen X in articular cartilage...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944854/effect-of-hippocampal-l%C3%A2-nbp-on-bdnf-and-trkb-expression-and-neurological-function-of-vascular-dementia-rats
#6
Yujing Huang, Zhaohui Li, Guangxian Nan
The pathogenesis of vascular dementia (VD) is associated with neuronal degeneration, apoptosis or necrosis following ischemic brain injury. L‑butylphthalide (L‑NBP), has been demonstrated to exhibit potent anti‑ischemic and anti‑VD effects, however the associated specific mechanism remains to be elucidated. The present study generated a VD rat model, in which the effect of L‑NBP on neurological function and expression levels of brain‑derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) were observed...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944851/microrna%C3%A2-96-regulates-the-proliferation-of-nucleus-pulposus-cells-by-targeting-arid2-akt-signaling
#7
Bo Tao, Jiaoyu Yi, Changzhao Huang, Wang Xu, Chao Qin, Lei Chen, Jincai Chen, Yan Gao, Ruiying Wang
The aberrant proliferation of nucleus pulposus (NP) cells has been reported to be implicated in the pathogenesis of intervertebral disc degeneration (IDD). Previous studies have demonstrated that microRNAs (miRNAs), which are a group of small noncoding RNAs, are critical regulators of cell proliferation in various pathologies. However, the role of miRNA‑96 (miR‑96) in the proliferation of NP cells remains to be determined. In the present study, reverse transcription‑quantitative polymerase chain reaction was used to investigate the expression of miR‑96 in NP tissues from patients with IDD and healthy tissues from patients with traumatic lumbar fracture as the control...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944839/alteration-of-oxidative-stress-and-inflammatory-cytokines-induces-apoptosis-in-diabetic-nephropathy
#8
Jibin Sha, Bo Sui, Xiaoqing Su, Qingfang Meng, Chenggang Zhang
Diabetic nephropathy (DN) is one of the most significant long‑term complications in terms of morbidity and mortality for diabetic patients; however, the exact cause remains unknown. To address this, the DN model was established, and oxidative stress indexes, including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH‑Px), and inflammatory cytokines, includinginterleukin‑6 (IL‑6), tumor necrosis factor‑alpha (TNF‑α) and transforming growth factor‑beta (TGF‑β), were examined by ELISA...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944802/subcellular-compartmentalisation-of-copper-iron-manganese-and-zinc-in-the-parkinson-s-disease-brain
#9
Sian Genoud, Blaine R Roberts, Adam P Gunn, Glenda M Halliday, Simon J G Lewis, Helen J Ball, Dominic J Hare, Kay L Double
Elevated iron and decreased copper levels are cardinal features of the degenerating substantia nigra pars compacta in the Parkinson's disease brain. Both of these redox-active metals, and fellow transition metals manganese and zinc, are found at high concentrations within the midbrain and participate in a range of unique biological reactions. We examined the total metal content and cellular compartmentalisation of manganese, iron, copper and zinc in the degenerating substantia nigra, disease-affected but non-degenerating fusiform gyrus, and unaffected occipital cortex in the post mortem Parkinson's disease brain compared with age-matched controls...
September 25, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28944753/asymmetry-of-movements-in-cftr-s-two-atp-sites-during-pore-opening-serves-their-distinct-functions
#10
Ben Sorum, Beáta Töröcsik, László Csanády
CFTR, the chloride channel mutated in cystic fibrosis (CF) patients, is opened by ATP binding to two cytosolic nucleotide binding domains (NBDs), but pore-domain mutations may also impair gating. ATP-bound NBDs dimerize occluding two nucleotides at interfacial binding sites; one site hydrolyzes ATP, the other is inactive. The pore opens upon tightening, and closes upon disengagement, of the catalytic site following ATP hydrolysis. Extent, timing, and role of non-catalytic-site movements are unknown. Here we exploit equilibrium gating of a hydrolysis-deficient mutant and apply F value analysis to compare timing of opening-associated movements at multiple locations, from the cytoplasmic ATP sites to the extracellular surface...
September 25, 2017: ELife
https://www.readbyqxmd.com/read/28944648/association-of-col11a1-4603c-t-polymorphism-with-cervical-disc-degeneration-in-collegiate-wrestlers
#11
Koji Koyama, Koichi Nakazato, Shogo Maeda, Naoki Kikuchi, Shingo Matsumoto, Kenji Hiranuma
BACKGROUND: The authors previously identified that COL11A1 gene polymorphism is not a susceptibility factor for lumbar disc degeneration (LDD) in athletes. However, the relationship between COL11A1 gene polymorphism and cervical disc degeneration (CDD) remains unclear. We hypothesized that significant associations between COL11A1 4603C/T gene polymorphism and CDD, but not LDD, in collegiate wrestlers exist. This study aims to examine the relationship between CDD, LDD, and COL11A1 4603C/T gene polymorphism in collegiate wrestlers...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28944439/hyperintense-signal-alteration-in-the-suprapatellar-fat-pad-on-mri-is-associated-with-degeneration-of-the-patellofemoral-joint-over-48%C3%A2-months-data-from-the-osteoarthritis-initiative
#12
Benedikt J Schwaiger, John Mbapte Wamba, Alexandra S Gersing, Michael C Nevitt, Luca Facchetti, Charles E McCulloch, Thomas M Link
OBJECTIVE: To analyze associations of suprapatellar fat pad (SPFP) hyperintense signal alterations and mass effect with progression of patellofemoral osteoarthritis (OA) and clinical symptoms over 48 months. MATERIALS AND METHODS: Subjects from the Osteoarthritis Initiative (n = 426; 51.8 ± 3.8 years; 49.8% women) without radiographic tibiofemoral OA underwent 3T-MRI of their right knees and clinical evaluation using the Knee Injury and Osteoarthritis Outcome Score at baseline and at 48 months...
September 24, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28944256/depressive-symptoms-are-frequent-in-atypical-parkinsonian-disorders
#13
Leonardo Almeida, Bilal Ahmed, Roger Walz, Sol De Jesus, Addie Patterson, Daniel Martinez-Ramirez, David Vaillancourt, Dawn Bowers, Herbert Ward, Michael S Okun, Nikolaus R McFarland
OBJECTIVE: To compare the incidence and prevalence of depressive symptoms in atypical parkinsonian (APD) syndromes versus Parkinson disease (PD). METHODS: In a large retrospective patient cohort we analyzed the incidence and prevalence of depressive symptoms using the Beck Depression Inventory (BDI) and evaluated subjects longitudinally on subsequent visits. For individuals who followed in subsequent visits we calculated incidence rates in person-years as a measure of incidence...
March 2017: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/28944237/next-generation-sequencing-reveals-the-mutational-landscape-of-clinically-diagnosed-usher-syndrome-copy-number-variations-phenocopies-a-predominant-target-for-translational-read-through-and-pex26-mutated-in-heimler-syndrome
#14
Christine Neuhaus, Tobias Eisenberger, Christian Decker, Sandra Nagl, Cornelia Blank, Markus Pfister, Ingo Kennerknecht, Cornelie Müller-Hofstede, Peter Charbel Issa, Raoul Heller, Bodo Beck, Klaus Rüther, Diana Mitter, Klaus Rohrschneider, Ute Steinhauer, Heike M Korbmacher, Dagmar Huhle, Solaf M Elsayed, Hesham M Taha, Shahid M Baig, Heidi Stöhr, Markus Preising, Susanne Markus, Fabian Moeller, Birgit Lorenz, Kerstin Nagel-Wolfrum, Arif O Khan, Hanno J Bolz
BACKGROUND: Combined retinal degeneration and sensorineural hearing impairment is mostly due to autosomal recessive Usher syndrome (USH1: congenital deafness, early retinitis pigmentosa (RP); USH2: progressive hearing impairment, RP). METHODS: Sanger sequencing and NGS of 112 genes (Usher syndrome, nonsyndromic deafness, overlapping conditions), MLPA, and array-CGH were conducted in 138 patients clinically diagnosed with Usher syndrome. RESULTS: A molecular diagnosis was achieved in 97% of both USH1 and USH2 patients, with biallelic mutations in 97% (USH1) and 90% (USH2), respectively...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28944207/predictive-factors-of-visual-outcome-of-malaysian-cataract-patients-a-retrospective-study
#15
Thanigasalam Thevi, Myron Anthony Godinho
AIM: To explore the associations between various characteristics of Malaysian cataract patients and their management, and their post-operative visual outcomes, to inform relevant bodies to reduce cataract-related blindness. METHODS: We conducted a descriptive secondary data analysis of cataract surgery patients in Melaka Hospital, from 2007 to 2014 using the National Eye Database (NED). Patient-related factors (demographic features, systemic and ocular comorbidities) and management-related factors (surgical duration, type of surgery, type of lens) were analysed for their association with visual outcome (acuity)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944191/mmp-2-rs24386-c-t-gene-polymorphism-and-the-phenotype-of-age-related-macular-degeneration
#16
Rasa Liutkeviciene, Vaiva Lesauskaite, Giedre Sinkunaite-Marsalkiene, Sandrita Simonyte, Reda Zemaitiene, Loresa Kriauciuniene, Dalia Zaliuniene
AIM: To examine the MMP-2 (-1306 C/T) gene polymorphism and the phenotype characterized by soft and hard drusen of early age-related macular degeneration (AMD) and geographic atrophy of late AMD form. METHODS: The study enrolled 850 investigations (290 AMD patients with soft and hard drusen, 34 with geographic atrophy and a random sample of the population n=526). Early AMD was classified according to the International Classification and Grading System. For geographic atrophy diagnosis the Age-Related Eye Disease Study classification was used...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944066/immune-mediated-cerebellar-ataxias-from-bench-to-bedside
#17
REVIEW
Hiroshi Mitoma, Mario Manto, Christiane S Hampe
The cerebellum is a vulnerable target of autoimmunity in the CNS. The category of immune-mediated cerebellar ataxias (IMCAs) was recently established, and includes in particular paraneoplastic cerebellar degenerations (PCDs), gluten ataxia (GA) and anti-GAD65 antibody (Ab) associated-CA, all characterized by the presence of autoantibodies. The significance of onconeuronal autoantibodies remains uncertain in some cases. The pathogenic role of anti-GAD65Ab has been established both in vitro and in vivo, but a consensus has not been reached yet...
2017: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/28943841/microglia-an-interface-between-the-loss-of-neuroplasticity-and-depression
#18
REVIEW
Gaurav Singhal, Bernhard T Baune
Depression has been widely accepted as a major psychiatric disease affecting nearly 350 million people worldwide. Research focus is now shifting from studying the extrinsic and social factors of depression to the underlying molecular causes. Microglial activity is shown to be associated with pathological conditions, such as psychological stress, pathological aging, and chronic infections. These are primary immune effector cells in the CNS and regulate the extensive dialogue between the nervous and the immune systems in response to different immunological, physiological, and psychological stressors...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28943836/evaluating-efficiencies-of-dual-aav-approaches-for-retinal-targeting
#19
Livia S Carvalho, Heikki T Turunen, Sarah J Wassmer, María V Luna-Velez, Ru Xiao, Jean Bennett, Luk H Vandenberghe
Retinal gene therapy has come a long way in the last few decades and the development and improvement of new gene delivery technologies has been exponential. The recent promising results from the first clinical trials for inherited retinal degeneration due to mutations in RPE65 have provided a major breakthrough in the field and have helped cement the use of recombinant adeno-associated viruses (AAV) as the major tool for retinal gene supplementation. One of the key problems of AAV however, is its limited capacity for packaging genomic information to a maximum of around 4...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28943783/light-and-compressed-gluinos-at-the-lhc-via-string-theory
#20
S S AbdusSalam
In this article, we show that making global fits of string theory model parameters to data is an interesting mechanism for probing, mapping and forecasting connections of the theory to real world physics. We considered a large volume scenario (LVS) with D3-brane matter fields and supersymmetry breaking. A global fit of the parameters to low-energy data shows that the set of LVS models are associated with light gluinos which are quasi-degenerate with the neutralinos and charginos they can promptly decay into, and thus they are possibly hidden to current LHC gluino search strategies...
2017: European Physical Journal. C, Particles and Fields
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