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https://www.readbyqxmd.com/read/27698519/uterotonics-for-non-emergent-caesarean-section-protocol-change-during-uk-licensed-drug-shortage
#1
C Malone, J R Acheson, J D Hinds, M H McComiskey
The aim was to assess the efficacy of Syntometrine (®) (500 micrograms ergometrine with 5 units oxytocin) as an appropriate alternative first-line uterotonic for use in elective caesarean section (CS) during a national shortage of UK-licensed IV oxytocin from April-June 2014. An observational study was performed involving 2 groups of 22 women undergoing elective CS in a UK DGH during this period. Primary endpoints included mean estimated blood loss (EBL), haemoglobin drop post-operatively and transfusion requirement...
September 2016: Ulster Medical Journal
https://www.readbyqxmd.com/read/26914893/does-oral-carbohydrate-supplementation-improve-labour-outcome-a-systematic-review-and-individual-patient-data-meta-analysis
#2
REVIEW
G L Malin, G J Bugg, J Thornton, M A Taylor, N Grauwen, R Devlieger, K R Kardel, M Kubli, J E Tranmer, N W Jones
BACKGROUND: Labour is a period of significant physical activity. The importance of carbohydrate intake to improve outcome has been recognised in sports medicine and general surgery. OBJECTIVES: To assess the effect of oral carbohydrate supplementation on labour outcomes. SEARCH STRATEGY: MEDLINE (1966-2014), Embase, the Cochrane Library and clinical trial registries. SELECTION CRITERIA: Randomised controlled trials (RCT) of women randomised to receive oral carbohydrate in labour (<6 cm dilated), versus placebo or standard care...
March 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/26655326/when-choice-becomes-limited-women-s-experiences-of-delay-in-labour
#3
Natalie Armstrong, Sara Kenyon
Choice and patient involvement in decision-making are strong aspirations of contemporary healthcare. One of the most striking areas in which this is played out is maternity care where recent policy has focused on choice and supporting normal birth. However, birth is sometimes not straightforward and unanticipated complications can rapidly reduce choice. We draw on the accounts of women who experienced delay during labour with their first child. This occurs when progress is slow, and syntocinon is administered to strengthen and regulate contractions...
December 9, 2015: Health (London)
https://www.readbyqxmd.com/read/26511939/carbetocin-versus-oxytocin-in-the-management-of-atonic-post-partum-haemorrhage-pph-after-vaginal-delivery-a-randomised-controlled-trial
#4
RANDOMIZED CONTROLLED TRIAL
Ahmed Mohamed Maged, AbdelGany M A Hassan, Nesreen A A Shehata
OBJECTIVE: The objective of this study is to compare the effectiveness and safety of carbetocin vs. oxytocin in the management of atonic post partum haemorrhage (PPH) after vaginal delivery. METHODS: A prospective randomised study was conducted in which 100 pregnant women were randomised into 2 equal groups: group 1 received Carbetocin 100 µgm (Pabal(®) Ferring, UK) and group 2 received oxytocin 5 IU (Syntocinon(®), Novartis, Switzerland). RESULTS: The amount of blood loss and the need for other uterotonics were significantly lower in the carbetocin group (811 ± 389...
May 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/26254207/prostaglandin-vaginal-gel-induction-of-labor-comparing-amniotomy-with-repeat-prostaglandin-gel
#5
RANDOMIZED CONTROLLED TRIAL
Michael Beckmann, Sailesh Kumar, Vicki Flenady, Ellen Harker
OBJECTIVE: The purpose of this study was to compare 2 inductions of labor protocols. STUDY DESIGN: Women with live singleton pregnancies at ≥37 + 0 weeks gestation who were booked for prostaglandins 2 (PGE2) vaginal gel induction with a modified Bishop's score of <7 were eligible for inclusion. After an evening dose of PGE2 vaginal gel, women were assigned randomly the next morning into the amniotomy or repeat-PGE2 group. The amniotomy group underwent artificial rupture of membranes (ARM), regardless of modified Bishop's score, and received further PGE2 doses only if ARM was not technically possible...
December 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26078882/determinants-and-outcomes-of-emergency-caesarean-section-following-failed-instrumental-delivery-5-year-observational-review-at-a-tertiary-referral-centre-in-london
#6
Sian McDonnell, Edwin Chandraharan
OBJECTIVES: To review the determinants for a failed operative vaginal delivery and to examine associated fetal and maternal morbidity. Design. Retrospective observational study. Setting. Large London Teaching Hospital. METHOD: A retrospective review of case notes during a 5-year period was carried out. RESULTS: Overall 119 women (0.44%) out of 26,856 births had a caesarean section following a failed instrumental delivery, which comprised 5...
2015: Journal of Pregnancy
https://www.readbyqxmd.com/read/25503617/oxytocin-for-frontotemporal-dementia-a-randomized-dose-finding-study-of-safety-and-tolerability
#7
RANDOMIZED CONTROLLED TRIAL
Elizabeth C Finger, Julia MacKinley, Mervin Blair, Lindsay D Oliver, Sarah Jesso, Maria C Tartaglia, Michael Borrie, Jennie Wells, Isabel Dziobek, Stephen Pasternak, Derek G V Mitchell, Katherine Rankin, Andrew Kertesz, Adam Boxer
OBJECTIVE: To determine the safety and tolerability of 3 doses of intranasal oxytocin (Syntocinon; Novartis, Bern, Switzerland) administered to patients with frontotemporal dementia (FTD). METHODS: We conducted a randomized, parallel-group, double-blind, placebo-controlled study using a dose-escalation design to test 3 clinically feasible doses of intranasal oxytocin (24, 48, or 72 IU) administered twice daily for 1 week to 23 patients with behavioral variant FTD or semantic dementia (clinicaltrials...
January 13, 2015: Neurology
https://www.readbyqxmd.com/read/25350407/-pharmaceutical-treatment-of-lactation-deficiency-lacks-evidence
#8
REVIEW
Paul Bryde Axelsson, Flemming Bjerrum, Ellen Christine Leth Løkkegaard
In this review we have looked at the evidence for the pharmacological treatment of lactation deficiency. Five RCTs (n = 166) of metoclopramide found no effect on lactation and two RCTs (n = 26) of older date and lesser quality found significant effect. One RCT (n = 51) of syntocinon found no effect on lactation and two older RCTs (n = 60) of lesser quality found significant effect. Three RCTs (n = 105) found significant effect of domperidone on lactation. Education on breastfeeding is important to avoid the need for pharmacological treatment...
February 24, 2014: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/25296671/delivery-outcomes-after-day-and-night-onset-of-labour
#9
Sandeep Kanwar, Ranjit Rabindran, Stephen W Lindow
OBJECTIVE: To describe the outcome of night onset of labour as compared with the day onset of labour to investigate if labour that begins at night is more efficient. DESIGN: Retrospective review of labour and delivery data. SETTING: A large United Kingdom maternity service. POPULATION: Over the period of 10 years, there were 30,022 deliveries, of which 19,842 were studied. METHODS: A United Kingdom maternity department database was used to identify deliveries over a 10-year period, and the delivery outcomes were retrieved from these records...
November 2015: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/25252517/where-does-ergometrine-stand-in-prevention-of-postpartum-haemorrhage-in-caesarean-section
#10
COMPARATIVE STUDY
Ghazala Mahmud, Kiran Javaid, Nasira Tasnim, Arfa Tabassum, Kausar Tasneem Bangash
OBJECTIVE: To compare the safety and efficacy of 10 units of intravenous syntocinon alone with 10 units intravenous syntocinon and 0.25 mg intramuscular ergometrine in the prevention of atonic uterine haemorrhage during caesarean section. METHOD: The quasi-experimental study was conducted at the Maternal and Child Health Centre, Unit I, Pakistan Institute of Medical Sciences, Islamabad, from November 1, 2010 to February 28, 2011. All women undergoing caesarean section were included in the study...
August 2014: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/25123119/treatment-of-insufficient-lactation-is-often-not-evidence-based
#11
Paul Bryde Axelsson, Flemming Bjerrum, Ellen Christine Leth Løkkegaard
INTRODUCTION: Breast milk has many advantages over formula for infants in developed and developing countries alike. Despite intentions of breastfeeding, some women develop insufficient lactation. Treatment options traditionally include breastfeeding education and pharmacotherapy. MATERIAL AND METHODS: An electronic questionnaire regarding treatment of insufficient lactation was sent to all obstetric departments (n = 21) and neonatal wards (n = 17) in Denmark. Three main questions were included which focused on: breastfeeding education for women, use of pharmacotherapy and availability of local guidelines...
July 2014: Danish Medical Journal
https://www.readbyqxmd.com/read/24971134/induction-of-labor-using-native-oxytip-in-comparison-to-foreign-oxytocin-syntocinon
#12
Fedyeh Haghollahi, Soghra Khazardoost, Sedigheh Hantoushzadeh, Mohammad Mehdi Naghizadeh, Batool Rashidi
OBJECTIVE: This study was conducted with the aim to investigate and compare Iranian produced and foreign oxytocin for use in induction of labor. MATERIALS AND METHODS: This random clinical trial was conducted on a population of 198 pregnant women with live fetus and cephalic presentation and conditions conducive to induction of labor, monitored by obstetricians and gynecologists. They were randomly divided into group A (n = 99) received 10 units of Syntocinon (Novartis Pharma Canada) in 500 cc Ringer lactate, and group B (n = 99) received 10 units of Oxytip (Caspian Tamin Company Iran) in 500 cc serum, who entered the study to commence induction, by signing written consent...
June 2014: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/24655553/the-effect-of-augmentation-of-labour-with-syntocinon-on-the-fetal-ctg-using-objective-computerised-analysis-a-nested-case-control-study
#13
C Y L Aye, C W G Redman, A Georgieva
OBJECTIVE: To investigate the effect of syntocinon augmentation on the fetal cardiotocogram (CTG) using computerised analysis. We hypothesised that syntocinon will have no direct effects on the fetal heart rate if used correctly. STUDY DESIGN: A retrospective, nested case-control study. SETTING: Intrapartum CTG records from the digital archive at the John Radcliffe Hospital, Oxford, UK. SUBJECTS: 110 women with singleton pregnancies of >36 weeks gestation, no known congenital abnormality, spontaneous onset of labour and syntocinon augmentation for failure to progress, with start time of syntocinon recorded, from between August 1998 and December 1999, extensively matched to 110 controls who had normally progressing labours...
May 2014: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/24508578/intranasal-oxytocin-in-the-treatment-of-autism-spectrum-disorders-a-review-of-literature-and-early-safety-and-efficacy-data-in-youth
#14
REVIEW
Evdokia Anagnostou, Latha Soorya, Jessica Brian, Annie Dupuis, Deepali Mankad, Sharon Smile, Suma Jacob
BACKGROUND: There is a paucity of treatments targeting core symptom domains in Autism Spectrum Disorder (ASD). Several animal models and research in typically developing volunteers suggests that manipulation of the oxytocin system may have therapeutic potential for the treatment of social deficits. We review the literature for oxytocin and ASD and report on early dosing, safety and efficacy data of multi-dose oxytocin on aspects of social cognition/function, as well as repetitive behaviors and co-occurring anxiety within ASD...
September 11, 2014: Brain Research
https://www.readbyqxmd.com/read/24457021/-misoprostol-off-label-use-in-the-treatment-of-post-partum-hemorrhage
#15
REVIEW
A Garrigue, F Pierre
INTRODUCTION: Current knowledge on off-label use of misoprostol for prevention and treatment of post-partum haemorrhage (PPH). MATERIALS AND METHODS: Systematic review of French and English literature by searching in PubMed, The Cochrane Library and recommendations of international scholarly societies and the World Health Organization. RESULTS: Oral misoprostol reduces the risk of severe PPH (≥1L) by more than 80% when compared to a placebo (P<0...
February 2014: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/24441052/the-effect-of-maternal-age-and-planned-place-of-birth-on-intrapartum-outcomes-in-healthy-women-with-straightforward-pregnancies-secondary-analysis-of-the-birthplace-national-prospective-cohort-study
#16
Yangmei Li, John Townend, Rachel Rowe, Marian Knight, Peter Brocklehurst, Jennifer Hollowell
OBJECTIVES: To describe the relationship between maternal age and intrapartum outcomes in 'low-risk' women; and to evaluate whether the relationship between maternal age and intrapartum interventions and adverse outcomes differs by planned place of birth. DESIGN: Prospective cohort study. SETTING: Obstetric units (OUs), midwifery units and planned home births in England. PARTICIPANTS: 63 371 women aged over 16 without known medical or obstetric risk factors, with singleton pregnancies, planning vaginal birth...
January 17, 2014: BMJ Open
https://www.readbyqxmd.com/read/23233269/intranasal-oxytocin-as-an-adjunct-to-risperidone-in-patients-with-schizophrenia-an-8-week-randomized-double-blind-placebo-controlled-study
#17
RANDOMIZED CONTROLLED TRIAL
Amirhossein Modabbernia, Farzin Rezaei, Bahman Salehi, Morteza Jafarinia, Mandana Ashrafi, Mina Tabrizi, Seyed M R Hosseini, Masih Tajdini, Ali Ghaleiha, Shahin Akhondzadeh
BACKGROUND: Impairment of oxytocinergic function and/or oxytocin receptor genetic abnormalities has been demonstrated in patients with schizophrenia. Oxytocin reverses emotional recognition deficit and might restore sense of trust in patients with schizophrenia. Some short-term studies have shown efficacy and tolerability of oxytocin in patients with schizophrenia. However, there is a lack of evidence on the efficacy and tolerability of oxytocin in patients with schizophrenia beyond 3 weeks...
January 2013: CNS Drugs
https://www.readbyqxmd.com/read/22767365/horner-s-syndrome-with-epidural-anaesthesia
#18
Rowena Sharma, Jayanta Chatterjee, Keith Edmonds
A 29-year-old woman, primigravida, had labour induced for post-maturity following an uncomplicated antenatal course. She requested an epidural prior to commencement of syntocinon. This was administered in the sitting position without complication. The midwife noted drooping of the right eyelid of the patient 6.5 h following insertion of the epidural. Blood pressure and CTG remained reassuring. The obstetric anaesthetist reviewed the labouring woman and noted a right-sided ptosis as well as the right cheek being flushed and dry...
2010: BMJ Case Reports
https://www.readbyqxmd.com/read/22540092/evaluating-trial-of-scar-in-patients-with-a-history-of-caesarean-section
#19
Aliya Islam, Ambreen Ehsan, Saadia Arif, Javeria Murtaza, Ayesha Hanif
AIMS: To analyze the outcome of trial of scar in patients with previous caesarean section and to assess the fetal and maternal complications after trial of scar. PATIENTS AND METHODS: The study was conducted at Military Hospital, Rawalpindi, Pakistan, with 375 pregnant patients who had a previous delivery by caesarean and who had regular antenatal checkup. Data were recorded on special pro-forms designed for the purpose. RESULTS: The results from the 375 patients who had one previous lower segment caesarean section due to non-recurrent causes were analyzed and compared with national and international studies...
April 2011: North American Journal of Medical Sciences
https://www.readbyqxmd.com/read/21995157/optimal-dose-of-an-anesthetic-in-epidural-anesthesia-and-its-effect-on-labor-duration-and-administration-of-vacuum-extractor-and-forceps
#20
N Cutura, V Soldo, S R Milovanović, Z Orescanin-Dusić, A Curković, B Tomović, S Janković-Raznatović
This study examined the factors that influence the optimal dose of epidural anesthesia (EA), its effect on labor duration, and the frequency of vacuum and forceps administration at the end of delivery. The study group included 100 women who underwent vaginal delivery with EA with administration of 0.125% bupivacaine. A control group included 100 vaginally delivered women, without EA administration. In both groups delivery was stimulated by syntocinon. The level of labor pain influenced the optimal bolus dose of EA more than the body mass...
2011: Clinical and Experimental Obstetrics & Gynecology
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