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https://www.readbyqxmd.com/read/29736552/comparison-of-two-configurations-of-transcranial-direct-current-stimulation-for-aphasia-treatment
#1
Kerstin Spielmann, W Mieke van de Sandt-Koenderman, Majanka H Heijenbrok-Kal, Gerard M Ribbers
OBJECTIVE: To compare 2 configurations of transcranial direct current stimulation (tDCS) for treatment of aphasia. DESIGN: Randomized cross-over study. SUBJECTS: Patients with chronic post-stroke aphasia (n = 13). METHODS: tDCS was combined with word-finding therapy in 3 single sessions. In session 1, sham-tDCS/pseudo-stimulation was applied. In sessions 2 and 3, 2 active configurations were provided in random order: anodal tDCS over the left inferior frontal gyrus (l-IFG) and anodal tDCS over the left posterior superior temporal gyrus (l-STG)...
May 8, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29735856/restless-legs-syndrome-and-quality-of-life-in-chronic-hemodialysis-patients
#2
R Kutlu, N Y Selcuk, S Sayin, O Kal
Context: Restless legs syndrome (RLS) is a sensorimotor disorder that often has a profound impact on sleep and one of the most troublesome conditions experienced in hemodialysis patients. Aims: The aim of study was to search frequency of RLS and effects of RLS on quality of life (QoL) in chronic hemodialysis patients. Settings and Design: Chronic hemodialysis patients of classical hemodialysis units were chosen. Length of the study was approximately 1 year. Subjects and Methods: Two hundred and thirty-seven patients were investigated...
May 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29670325/retinal-detachment-in-albinism
#3
Ahmad M Mansour, Jay Chhablani, J Fernando Arevalo, Lihteh Wu, Ravi Sharma, Suthasinee Sinawat, Tharikarn Sujirakul, Alexandre Assi, Wandsy M Vélez-Vázquez, Mohamad A Mansour, Ozcan Kayikcioglu, Cem Kucukerdonmez, Ali Kal
Purpose: To report the visual and anatomic outcomes of albino retinal detachment (ARD) repair. Methods: Collaborative retrospective analysis of ARD. Outcome measures were number of surgical interventions, final retinal reattachment, and best corrected visual acuity (BCVA) at last follow-up. Results: Seventeen eyes of 16 patients (12 males; mean age =37.8 years) had the following complications at presentation: macula off (14), total (7) or inferior detachment (5), proliferative vitreoretinopathy (5), detectable break (16), lattice (5), horseshoe tears (9), and giant tear or dialysis (4)...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29618199/sc-3-or-hclo-4-activation-of-a-nonheme-fe-iii-ooh-intermediate-for-the-rapid-hydroxylation-of-cyclohexane-and-benzene
#4
Subhasree Kal, Apparao Draksharapu, Lawrence Que
[Fe(β-BPMCN)(CH3 CN)2 ]2+ (1, BPMCN = N,N'-bis(pyridyl-2-methyl)- N,N'-dimethyl-trans-1,2-diaminocyclo-hexane) is a relatively poor catalyst for cyclohexane hydroxylation by H2 O2 and cannot perform benzene hydroxylation. However, addition of Sc3+ activates the 1/H2 O2 reaction mixture to be able to hydroxylate cyclohexane and benzene within seconds at -40 °C. A metastable S = ½ FeIII -(η1 -OOH) intermediate 2 is trapped at -40 °C that undergoes rapid decay upon addition of Sc3+ at rates independent of [substrate] but linearly dependent on [Sc3+ ]...
April 5, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29581669/comparision-of-the-effectiveness-of-eswt-and-ultrasound-treatments-in-myofascial-pain-syndrome-randomized-sham-controlled-study
#5
Semra Aktürk, Arzu Kaya, Derya Çetintaş, Gürkan Akgöl, Arif Gülkesen, Gül Ayden Kal, Tülin Güçer
[Purpose] The purpose of this study is to compare effectiveness of extracorporeal shock wave therapy (ESWT), ultrasound (US) and sham ESWT in the treatment of myofascial pain syndrome (MPS). [Subjects and Methods] Sixty MPS patients aged 18-60 years were included in the study. The patients were randomized equally into 3 groups. Group 1 received ESWT for 4 session with 3 day-intervals. Group 2 received 4 sessions of sham ESWT. US was applied to Group 3 for 10 sessions. All patients were recommended an exercise program...
March 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29581554/heart-rate-reduction-decreases-central-blood-pressure-in-sick-sinus-syndrome-patients-with-a-permanent-cardiac-pacemaker
#6
Tuuli Teeäär, Martin Serg, Kaido Paapstel, Jaak Kals, Mart Kals, Mihkel Zilmer, Jaan Eha, Priit Kampus
Increased resting heart rate (HR) contributes to higher cardiovascular mortality and morbidity in the healthy as well as in people with cardiovascular diseases, possibly due to elevated blood pressure (BP) among other mechanisms. Data on the relationship between HR and central (aortic) BP remains controversial, however, and concerning β-blockers, it has been proposed that pharmacological HR lowering is associated with augmentation of central BP. We aimed to study the role of pharmacologically unaffected HR on central BP indices in sick sinus syndrome patients with a permanent cardiac pacemaker in the HR range from 40 to 90 bpm...
March 27, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29571088/over-focused-the-relation-between-patients-inclination-for-conscious-control-and-single-and-dual-task-motor-performance-after-stroke
#7
R P M Denneman, E C Kal, H Houdijk, J van der Kamp
BACKGROUND: Many stroke patients are inclined to consciously control their movements. This is thought to negatively affect patients' motor performance, as it disrupts movement automaticity. However, it has also been argued that conscious control may sometimes benefit motor performance, depending on the task or patientś motor or cognitive capacity. AIM: To assess whether stroke patients' inclination for conscious control is associated with motor performance, and explore whether the putative association differs as a function of task (single- vs dual) or patientś motor and cognitive capacity...
March 5, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29523651/transcranial-direct-current-stimulation-does-not-improve-language-outcome-in-subacute-poststroke-aphasia
#8
Kerstin Spielmann, W Mieke E van de Sandt-Koenderman, Majanka H Heijenbrok-Kal, Gerard M Ribbers
BACKGROUND AND PURPOSE: The aim of the present study is to investigate the effect of transcranial direct current stimulation on word-finding treatment outcome in subacute poststroke aphasia. METHODS: In this multi-center, double-blind, randomized controlled trial with 6-month follow-up, we included 58 patients with subacute aphasia (<3 months poststroke), who were enrolled in a stroke rehabilitation program. Patients participated in 2 separate intervention weeks...
April 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29485103/evaluating-the-in-vivo-glial-response-to-miniaturized-parylene-cortical-probes-coated-with-an-ultra-fast-degrading-polymer-to-aid-insertion
#9
Meng-Chen Lo, Shuwu Wang, Sagar Singh, Vinod B Damodaran, Ijaz Ahmed, Kevin Coffey, David Barker, Kshitij Saste, Karanvir Kals, Hilton M Kaplan, Joachim Kohn, David I Shreiber, Jeffrey D Zahn
OBJECTIVE: Despite the feasibility of short-term neural recordings using implantable microelectrodes, attaining reliable, chronic recordings remains a challenge. Most neural recording devices suffer from a long-term tissue response, including gliosis, at the device-tissue interface. It was hypothesized that smaller, more flexible intracortical probes would limit gliosis by providing a better mechanical match with surrounding tissue. APPROACH: This paper describes the in vivo evaluation of flexible parylene microprobes designed to improve the interface with the adjacent neural tissue to limit gliosis and thereby allow for improved recording longevity...
June 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29480257/choroidal-thickness-in-patients-with-fibromyalgia-and-correlation-with-disease-severity
#10
Mahmut Oguz Ulusoy, Ali Kal, Selen Işik-Ulusoy, Öznur Kal
Purpose: To evaluate and compare choroidal thickness in patients with fibromyalgia (FM) and healthy controls. Methods: In this prospective, cross-sectional study, forty eyes of 40 patients with FM and 40 eyes of 40 age- and sex-matched healthy subjects were enrolled. FM was diagnosed according to the American College of Rheumatology criteria. The choroidal thickness measurements of the subjects were obtained using spectral-domain optical coherence tomography (RTVue-100, Optovue)...
March 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29467753/the-plasma-kallikrein-kininogen-pathway-is-critical-in-the-pathogenesis-of-colitis-in-mice
#11
Bo Wang, Aizhen Yang, Zhenzhen Zhao, Chao He, Yuanyuan Liu, Robert W Colman, Jihong Dai, Yi Wu
The kallikrein-kinin system (KKS) consists of two serine proteases, prekallikrein (pKal) and factor XII (FXII), and a cofactor, high-molecular-weight kininogen (HK). Upon activation of the KKS, HK is cleaved to release bradykinin. Although the KKS is activated in humans and animals with inflammatory bowel disease (IBD), its role in the pathogenesis of IBD has not been characterized. In the present study, we determined the role of the KKS in the pathogenesis of IBD using mice that lack proteins involved in the KKS...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29423943/effect-of-body-condition-score-and-reuse-of-progesterone-releasing-intravaginal-devices-on-conception-rate-following-timed-artificial-insemination-in-nelore-cows
#12
L L Pereira, A P Ferreira, W G Vale, L R Serique, Kal Neves, A C Morini, B M Monteiro, Ahh Minervino
This study had the aim of investigating the efficiency of timed artificial insemination (TAI) through the progesterone-releasing intravaginal device (PRID), used in new condition and for the second and third times in Nelore cows. The effects of device reuse and body condition score (BCS) on the conception rate (CR) were evaluated in 1,122 multiparous Nelore cows (mean BCS of 2.7 ± 0.4), which were randomly distributed into three groups that received new (n = 330), once (n = 439) and twice used (n = 353) PRID...
February 9, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29380728/conversion-from-tacrolimus-to-everolimus-with-complete-and-early-glucocorticoid-withdrawal-after-kidney-transplantation-a-randomised-trial
#13
R Bouamar, N Shuker, J A J Osinga, M C Clahsen-van Groningen, J Damman, C C Baan, J van de Wetering, A T Rowshani, J Kal-van Gestel, W Weimar, T van Gelder, D A Hesselink
BACKGROUND: While conversion from cyclosporine to everolimus is well documented, conversion from tacrolimus has been poorly studied. In this randomised, controlled trial the safety and tolerability of switching from tacrolimus to everolimus with glucocorticoid withdrawal after living-donor kidney transplantation was studied. METHODS: A total of 194 patients were planned to be randomised 1:1 to either continue tacrolimus or to convert to everolimus at month 3 after transplantation...
January 2018: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29343203/cognition-health-related-quality-of-life-and-depression-ten-years-after-moderate-to-severe-traumatic-brain-injury-a-prospective-cohort-study
#14
Erik Grauwmeijer, Majanka Heijenbrok-Kal, Lianne Peppel, Chantal Hartjes, Iain Haitsma, Inge de Koning, Gerard Ribbers
The aim of this study was to evaluate cognitive function ten years after moderate-severe TBI and to investigate the associations between cognitive function, depression and Health-Related Quality of Life (HRQoL). In this prospective cohort study, with measurements at 3, 6, 12, 18, 24, 36, and 120 months post-TBI, patients aged 18-67 years (N=113) with moderate-severe TBI were recruited. Main outcome measures were depression (CES-D), subjective cognitive functioning (CFQ), objective cognitive functioning, and HRQoL (SF-36)...
January 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29314768/medium-and-long-chain-acylcarnitines-are-associated-with-osteoarthritis-severity-and-arterial-stiffness-in-end-stage-osteoarthritis-patients-a-case-control-study
#15
Kaspar Tootsi, Jaak Kals, Mihkel Zilmer, Kaido Paapstel, Aigar Ottas, Aare Märtson
AIM: Arterial pathology has been suggested to be involved in osteoarthritis (OA). Metabolic profiling enables the determination of low-molecular-weight molecules, which might further explain the pathogenesis of OA and its relationship with cardiovascular diseases (CVD). The aim of this study was to compare the metabolic profile of lipid metabolism-related compounds and arterial stiffness in OA patients and in controls. METHOD: The serum of 70 end-stage OA patients prior to joint replacement surgery and 82 age-matched controls were analyzed by the AbsoluteIDQ™ p180 kit (BIOCRATES Life Sciences AG, Innsbruck, Austria) using the targeted metabolomic approach...
January 4, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29283015/negative-pressure-ventilation-enhances-acinar-perfusion-in-isolated-rat-lungs
#16
Kal E Watson, Gilad S Segal, Robert L Conhaim
We compared acinar perfusion in isolated rat lungs ventilated using positive or negative pressures. The lungs were ventilated with air at transpulmomary pressures of 15/5 cm H2 O, at 25 breaths/min, and perfused with a hetastarch solution at Ppulm art /PLA pressures of 10/0 cm H2 O. We evaluated overall perfusability from perfusate flows, and from the venous concentrations of 4-µm diameter fluorescent latex particles infused into the pulmonary circulation during perfusion. We measured perfusion distribution from the trapping patterns of those particles within the lung...
January 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/29261352/incrementally-expandable-transjugular-intrahepatic-portosystemic-shunts-single-center-experience
#17
Jie Cui, Sara E Smolinski, Fengyong Liu, Dihua Xu, Kal Dulaimy, Zubin Irani
OBJECTIVE: The purpose of this study is to investigate the long-term safety and efficacy of a small-diameter expandable transjugular intrahepatic portosystemic shunt (TIPS) in the management of portal hypertension. MATERIALS AND METHODS: This single-center retrospective study included 28 patients (12 women and 16 men; mean age, 56.9 years) who underwent small-diameter expandable TIPS creation between 2008 and 2010 for refractory ascites (n = 15; mean [± SD] model for end-stage liver disease [MELD] score, 15...
February 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29241584/a-schizophrenia-linked-kalrn-coding-variant-alters-neuron-morphology-protein-function-and-transcript-stability
#18
Theron A Russell, Melanie J Grubisha, Christine L Remmers, Seok Kyu Kang, Marc P Forrest, Katharine R Smith, Katherine J Kopeikina, Ruoqi Gao, Robert A Sweet, Peter Penzes
BACKGROUND: Large-scale genetic studies have revealed that rare sequence variants, including single nucleotide variants (SNVs), in glutamatergic synaptic genes are enriched in schizophrenia patients. However, the majority are too rare to show any association with disease and have not been examined functionally. One such SNV, KALRN-P2255T, displays a penetrance that greatly exceeds that of previously identified schizophrenia-associated SNVs. Therefore, we sought to characterize its effects on the function of kalirin (Kal)-9, a dual Ras-related C3 botulinum toxin substrate 1 and Ras homologue gene family, member A (RhoA) guanine nucleotide exchange factor, upregulated in human schizophrenia brain tissue...
March 15, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29205873/evaluation-of-dry-eye-using-anterior-segment-optical-coherence-tomography-in-patients-with-end-stage-renal-disease-undergoing-hemodialysis
#19
Öznur Kal, Mahmut Oğuz Ulusoy, Ali Kal, Gülşah Tanriaşki, Şefik Cezairlioğlu
The aim of the present study was to evaluate dry eye parameters with conventional tests and tear meniscus with Anterior Segment Optical Coherence Tomography (AS-OCT) in patients with end-stage renal disease (ESRD). Thirty-eight ESRD patients undergoing hemodialysis, and 40 healthy individuals were enrolled. An ocular surface disease index questionnaire (OSDI) was administered. Before conventional dry eye tests, tear meniscus were evaluated using AS-OCT. After a complete ocular examination, Schirmer and break-up time (BUT) tests were performed and probable corneal staining was investigated...
December 4, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29171132/structured-education-to-improve-primary-care-management-of-headache-how-long-do-the-benefits-last-a-follow-up-observational-study
#20
M Braschinsky, S Haldre, M Kals, M Arge, B Saar, M Niibek, Z Katsarava, T J Steiner
BACKGROUND AND PURPOSE: Our earlier study showed that structured education of general practitioners (GPs) improved their practice in headache management. Here the duration of this effect was assessed. METHODS: In a follow-up observational study in southern Estonia, subjects were the same six GPs as previously, managing patients presenting with headache as the main complaint. Data reflecting their practice were collected prospectively during a 1-year period commencing 2 years after the educational intervention...
March 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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