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https://www.readbyqxmd.com/read/29343203/cognition-health-related-quality-of-life-and-depression-ten-years-after-moderate-to-severe-traumatic-brain-injury-a-prospective-cohort-study
#1
Erik Grauwmeijer, Majanka Heijenbrok-Kal, Lianne Peppel, Chantal Hartjes, Iain Haitsma, Inge de Koning, Gerard Ribbers
The aim of this study was to evaluate cognitive function ten years after moderate-severe TBI and to investigate the associations between cognitive function, depression and Health-Related Quality of Life (HRQoL). In this prospective cohort study, with measurements at 3, 6, 12, 18, 24, 36, and 120 months post-TBI, patients aged 18-67 years (N=113) with moderate-severe TBI were recruited. Main outcome measures were depression (CES-D), subjective cognitive functioning (CFQ), objective cognitive functioning, and HRQoL (SF-36)...
January 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29314768/medium-and-long-chain-acylcarnitines-are-associated-with-osteoarthritis-severity-and-arterial-stiffness-in-end-stage-osteoarthritis-patients-a-case-control-study
#2
Kaspar Tootsi, Jaak Kals, Mihkel Zilmer, Kaido Paapstel, Aigar Ottas, Aare Märtson
AIM: Arterial pathology has been suggested to be involved in osteoarthritis (OA). Metabolic profiling enables the determination of low-molecular-weight molecules, which might further explain the pathogenesis of OA and its relationship with cardiovascular diseases (CVD). The aim of this study was to compare the metabolic profile of lipid metabolism-related compounds and arterial stiffness in OA patients and in controls. METHOD: The serum of 70 end-stage OA patients prior to joint replacement surgery and 82 age-matched controls were analyzed by the AbsoluteIDQ™ p180 kit (BIOCRATES Life Sciences AG, Innsbruck, Austria) using the targeted metabolomic approach...
January 4, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29283015/express-negative-pressure-ventilation-enhances-acinar-perfusion-in-isolated-rat-lungs
#3
Kal E Watson, Gilad S Segal, Robert L Conhaim
No abstract text is available yet for this article.
January 1, 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/29261352/incrementally-expandable-transjugular-intrahepatic-portosystemic-shunts-single-center-experience
#4
Jie Cui, Sara E Smolinski, Fengyong Liu, Dihua Xu, Kal Dulaimy, Zubin Irani
OBJECTIVE: The purpose of this study is to investigate the long-term safety and efficacy of a small-diameter expandable transjugular intrahepatic portosystemic shunt (TIPS) in the management of portal hypertension. MATERIALS AND METHODS: This single-center retrospective study included 28 patients (12 women and 16 men; mean age, 56.9 years) who underwent small-diameter expandable TIPS creation between 2008 and 2010 for refractory ascites (n = 15; mean [± SD] model for end-stage liver disease [MELD] score, 15...
December 20, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29241584/a-schizophrenia-linked-kalrn-coding-variant-alters-neuron-morphology-protein-function-and-transcript-stability
#5
Theron A Russell, Melanie J Grubisha, Christine L Remmers, Seok Kyu Kang, Marc P Forrest, Katharine R Smith, Katherine J Kopeikina, Ruoqi Gao, Robert A Sweet, Peter Penzes
BACKGROUND: Large-scale genetic studies have revealed that rare sequence variants, including single nucleotide variants (SNVs), in glutamatergic synaptic genes are enriched in schizophrenia patients. However, the majority are too rare to show any association with disease and have not been examined functionally. One such SNV, KALRN-P2255T, displays a penetrance that greatly exceeds that of previously identified schizophrenia-associated SNVs. Therefore, we sought to characterize its effects on the function of kalirin (Kal)-9, a dual Ras-related C3 botulinum toxin substrate 1 and Ras homologue gene family, member A (RhoA) guanine nucleotide exchange factor, upregulated in human schizophrenia brain tissue...
November 7, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29205873/evaluation-of-dry-eye-using-anterior-segment-optical-coherence-tomography-in-patients-with-end-stage-renal-disease-undergoing-hemodialysis
#6
Öznur Kal, Mahmut Oğuz Ulusoy, Ali Kal, Gülşah Tanriaşki, Şefik Cezairlioğlu
The aim of the present study was to evaluate dry eye parameters with conventional tests and tear meniscus with Anterior Segment Optical Coherence Tomography (AS-OCT) in patients with end-stage renal disease (ESRD). Thirty-eight ESRD patients undergoing hemodialysis, and 40 healthy individuals were enrolled. An ocular surface disease index questionnaire (OSDI) was administered. Before conventional dry eye tests, tear meniscus were evaluated using AS-OCT. After a complete ocular examination, Schirmer and break-up time (BUT) tests were performed and probable corneal staining was investigated...
December 4, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29171132/structured-education-to-improve-primary-care-management-of-headache-how-long-do-the-benefits-last-a-follow-up-observational-study
#7
Mark Braschinsky, Sulev Haldre, Mart Kals, Marge Arge, Bruno Saar, Maris Niibek, Zaza Katsarava, Timothy J Steiner
BACKGROUND: Our earlier study showed that structured education of general practitioners (GPs) improved their practice in headache management. Here we assess duration of this effect. METHODS: In a follow-up observational study in Southern Estonia, subjects were the same six GPs as previously, managing patients presenting with headache as the main complaint. Data reflecting their practice were collected prospectively during a 1-year period commencing 2 years after the educational intervention...
November 24, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29169368/inactive-lifestyles-and-sedentary-behavior-in-persons-with-chronic-aneurysmal-subarachnoid-hemorrhage-evidence-from-accelerometer-based-activity-monitoring
#8
Wouter J Harmsen, Gerard M Ribbers, Majanka H Heijenbrok-Kal, Johannes B J Bussmann, Emiel M Sneekes, Ladbon Khajeh, Fop van Kooten, Sebastian J C M M Neggers, Rita J van den Berg-Emons
BACKGROUND: Aneurysmal subarachnoid hemorrhage (a-SAH) is a potential life-threatening stroke. Because survivors may be at increased risk for inactive and sedentary lifestyles, this study evaluates physical activity (PA) and sedentary behavior (SB) in the chronic phase after a-SAH. METHODS: PA and SB were objectively measured at six months post a-SAH with an accelerometer-based activity monitor, with the aim to cover three consecutive weekdays. Total time spent in PA (comprising walking, cycling, running and non-cyclic movement) and SB (comprising sitting and lying) was determined...
November 23, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29119998/development-of-a-computationally-designed-polymeric-adsorbent-specific-for-mycotoxin-patulin
#9
Elena V Piletska, Demi Pink, Kal Karim, Sergey A Piletsky
Patulin is a toxic compound which is found predominantly in apples affected by mould rot. Since apples and apple-containing products are a popular food for the elderly, children and babies, the monitoring of the toxin is crucial. This paper describes a development of a computationally-designed polymeric adsorbent for the solid-phase extraction of patulin, which provides an effective clean-up of the food samples and allows the detection and accurate quantification of patulin levels present in apple juice using conventional chromatography methods...
November 9, 2017: Analyst
https://www.readbyqxmd.com/read/29117792/mortality-after-elective-and-ruptured-abdominal-aortic-aneurysm-surgical-repair-12-year-single-center-experience-of-estonia
#10
J Lieberg, L-L Pruks, M Kals, K Paapstel, A Aavik, J Kals
BACKGROUND AND AIMS: Abdominal aortic aneurysm is a degenerative vascular pathology with high mortality due to its rupture, which is why timely treatment is crucial. The current single-center retrospective study was undertaken to analyze short- and long-term all-cause mortality after operative treatment of abdominal aortic aneurysm and to examine the factors that influence outcome. MATERIAL AND METHODS: The data of all abdominal aortic aneurysm patients treated with open repair or endovascular aneurysm repair in 2004-2015 were retrospectively retrieved from the clinical database of Tartu University Hospital...
November 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29115936/analyses-of-methylomes-of-upland-and-lowland-switchgrass-panicum-virgatum-ecotypes-using-medip-seq-and-bs-seq
#11
Mollee Dworkin, Shaojun Xie, Malay Saha, Jyothi Thimmapuram, Venu Kal Kalavacharla
BACKGROUND: Switchgrass is a crop with many desirable traits for bioenergy production. Plant genomes have high DNA methylation levels throughout genes and transposable elements and DNA methylation is known to play a role in silencing transposable elements. Here we analyzed methylomes in two switchgrass genotypes AP13 and VS16. AP13 is derived from a lowland ecotype and VS16, typically considered drought-tolerant, is derived from an upland ecotype, both genotypes are tetraploid (2n = 4× = 36)...
November 7, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29071548/are-differences-between-groups-different-at-different-occasions
#12
Jimmie Leppink, Patricia O'Sullivan, Kal Winston
No abstract text is available yet for this article.
October 25, 2017: Perspectives on Medical Education
https://www.readbyqxmd.com/read/29038806/kinetics-of-volatile-impurity-removal-from-silicon-by-electron-beam-melting-for-photovoltaic-applications
#13
Shuang Shi, Pengting Li, Jianxiong Meng, Dachuan Jiang, Yi Tan, H M Noor Ul Huda Khan Asghar
A full domain control model is established for impurity transportation in the liquid phase, gas-liquid interface and gas phase of silicon to analyze the dynamic mechanics of impurity removal. The results show that the overall mass transfer coefficient mainly depends on the temperature and the chamber pressure. Its value increases with the increase of temperature or the decrease of chamber pressure. Under the same melting condition, the order of the overall mass transfer coefficients for P, Al and Ca is kP > kAl > kCa, indicating that P is easier to remove by evaporation...
October 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28986077/inverse-relations-of-serum-phosphatidylcholines-and-lysophosphatidylcholines-with-vascular-damage-and-heart-rate-in-patients-with-atherosclerosis
#14
K Paapstel, J Kals, J Eha, K Tootsi, A Ottas, A Piir, M Jakobson, J Lieberg, M Zilmer
BACKGROUND AND AIMS: The rapidly growing discipline of lipidomics allows the study of a wide spectrum of lipid species in body fluids and provides new insights into the pathogenesis of cardiovascular disease. We investigated serum phosphatidylcholine (PC) and lysophosphatidylcholine (lysoPC) species in relation to arterial stiffness, hemodynamics, and endothelial dysfunction in symptomatic patients with atherosclerosis and in healthy controls. METHODS AND RESULTS: Thirty-two patients with peripheral arterial disease (age 61...
August 2, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28865530/the-4-quadrants-acute-pathology-in-the-abdomen-and-current-imaging-guidelines
#15
Bradley Mattson, Kal Dulaimy
With several different imaging options available, it is not surprising that health care providers are unsure which imaging study is most appropriate for evaluating patients who present to the emergency department with abdominal pain. The American College of Radiology, currently, has appropriateness criteria for patients presenting with right upper, right lower, and left lower quadrant pain, and there are different variants for each of these quadrants. Clinicians should be aware of the American College of Radiology appropriateness criteria and, whenever possible, should be using criteria as guide to help them order the most appropriate imaging study...
August 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/28818006/the-role-of-the-bdnf-val66met-polymorphism-in-recovery-of-aphasia-after-stroke
#16
Riemke G A de Boer, Kerstin Spielmann, Majanka H Heijenbrok-Kal, Rick van der Vliet, Gerard M Ribbers, W Mieke E van de Sandt-Koenderman
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is assumed to play a role in mediating neuroplasticity after stroke. Carriers of the function-limiting Val66Met (rs6265) single nucleotide polymorphism (SNP) may have a downregulation in BDNF secretion, which may lead to a poorer prognosis after stroke compared to noncarriers in motor learning and motor function recovery. The present study investigates whether this polymorphism may also affect the recovery of poststroke aphasia (ie, language impairment)...
August 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28808141/a-critical-role-for-plasma-kallikrein-in-the-pathogenesis-of-autoantibody-induced-arthritis
#17
Aizhen Yang, Junsong Zhou, Bo Wang, Jihong Dai, Robert W Colman, Wenchao Song, Yi Wu
The plasma kallikrein-kinin system (KKS) consists of serine proteases, prekallikrein (pKal) and factor XII (FXII), and a cofactor, high-MW kininogen (HK). Upon activation, activated pKal and FXII cleave HK to release bradykinin. Activation of this system has been noted in patients with rheumatoid arthritis, and its pathogenic role has been characterized in animal arthritic models. In this study, we generated 2 knockout mouse strains that lacked pKal and HK and determined the role of KKS in autoantibody-induced arthritis...
August 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28772669/in-situ-studies-of-structure-transformation-and-al-coordination-of-kal-moo%C3%A2-%C3%A2-during-heating-by-high-temperature-raman-and-27-al-nmr-spectroscopies
#18
Min Wang, Jinglin You, Alexander Sobol, Liming Lu, Jian Wang, Yingfang Xie
Recent interest in optimizing composition and synthesis conditions of functional crystals, and the further exploration of new possible candidates for tunable solid-state lasers, has led to significant research on compounds in this family M(I)M(III)(M(VI)O₄)₂ (M(I) = alkali metal, M(III) = Al, In, Sc, Fe, Bi, lanthanide; M(VI) = Mo, W). The vibrational modes, structure transformation, and Al coordination of crystalline, glassy, and molten states of KAl(MoO₄)₂ have been investigated by in-situ high temperature Raman scattering and (27)Al magic angle spinning nuclear magnetic resonance (MAS NMR) spectroscopy, together with first principles density functional simulation of room temperature Raman spectrum...
March 17, 2017: Materials
https://www.readbyqxmd.com/read/28766494/resting-energy-expenditure-a-valuable-predictor-for-kt-vurea-in-peritoneal-dialysis-patients%C3%A2
#19
Tian Xu, Jingyuan Xie, Weiming Wang, Hong Ren, Nan Chen
OBJECTIVE: The objective of this study was to identify an effective method for predicting small-molecule solute removal at the commencement of or before peritoneal dialysis (PD). METHODS: The PD patients with a dialysis delivery of 8 L/d and a residual kidney function (RKF) ≤ 5 mL/min were enrolled in the study. Fat-free lean body mass (FFM) and resting energy expenditure (REE) were measured using bioelectrical impedance (BIA). A receiver operating characteristic (ROC) curve was drawn to determine the threshold value for REE...
September 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28737953/metabolic-factors-and-oxidative-stress-in-osteoarthritis-a-case-control-study
#20
Kaspar Tootsi, Aare Märtson, Jaak Kals, Kaido Paapstel, Mihkel Zilmer
Previous studies suggest that metabolic disturbances might be involved in the development of osteoarthritis (OA). Associations have been found between the individual components of metabolic syndrome (MetS) and OA. MetS has been associated with increased oxidative stress (OxS). The study aimed to clarify the role of MetS components in OA and to evaluate the levels of OxS in OA patients and in age-matched controls. Fifty-five patients with end-stage OA (age 63 ± 7 years) prior to hip or knee joint replacement surgery and 55 age-, gender- and body mass index matched controls (61 ± 8 years) were enrolled in the study...
July 24, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
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