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Silvia Ravagnan, Laura Tomassone, Fabrizio Montarsi, Aleksandra Iwona Krawczyk, Eleonora Mastrorilli, Hein Sprong, Adelaide Milani, Luca Rossi, Gioia Capelli
BACKGROUND: Borrelia miyamotoi is a spirochete transmitted by several ixodid tick species. It causes a relapsing fever in humans and is currently considered as an emerging pathogen. In Europe, B. miyamotoi seems to occur at low prevalence in Ixodes ricinus ticks but has a wide distribution. Here we report the first detection of B. miyamotoi in Ixodes ricinus ticks collected in two independent studies conducted in 2016 in the north-eastern and north-western Alps, Italy. RESULTS: Three out of 405 nymphs (0...
March 20, 2018: Parasites & Vectors
Klaudia Sowula, Jacek Składzień, Joanna Szaleniec, Jolanta Gawlik
infections are borreliosis (Lyme disease) and tick-borne encephalitis (TBE). Lately there is growing incidence of Bartonella, Babesia, Anaplasma and Brucella co-infections. The similarity between the symptoms of tick-borne diseases and other pathologies causes serious diagnostic issues. MATERIAL AND METHODS: 216 patients aged 18-55, who presented to the outpatient clinic for tick-borne diseases in the years 2014-2016, were enrolled in the study. The patients had been diagnosed with Lyme disease and co-infections...
February 28, 2018: Otolaryngologia Polska
Hein Sprong, Tal Azagi, Dieuwertje Hoornstra, Ard M Nijhof, Sarah Knorr, M Ewoud Baarsma, Joppe W Hovius
Lyme borreliosis (LB) and other Ixodes ricinus-borne diseases (TBDs) are diseases that emerge from interactions of humans and domestic animals with infected ticks in nature. Nature, environmental and health policies at (inter)national and local levels affect the risk, disease burden and costs of TBDs. Knowledge on ticks, their pathogens and the diseases they cause have been increasing, and resulted in the discovery of a diversity of control options, which often are not highly effective on their own. Control strategies involving concerted actions from human and animal health sectors as well as from nature managers have not been formulated, let alone implemented...
March 6, 2018: Parasites & Vectors
Nicholas H Ogden
Marieta AH Braks, Sipke E van Wieren, Willem Takken and Hein Sprong, EditorsEcology and prevention of Lyme borreliosis. In: Ecology and control of vector-borne diseases Volume 4Wageningen: Wageningen Academic Publishers; 2016.462 pages, ISBN 1875-0699.
March 6, 2018: Parasites & Vectors
Knut Eirik Eliassen, Harald Reiso, Dag Berild, Morten Lindbæk
OBJECTIVES: Comparison of the three most commonly used antibiotics for erythema migrans (EM) in Norwegian primary care. METHODS: A randomised, parallel, controlled trial. Treatments were open to the patients, but blinded for the GPs and investigators. Patients aged ≥18 years, clinically diagnosed with EM were eligible for inclusion. Block randomisation was processed in blocks of six. Patients were assigned to receive one of three antibiotic treatments for 14 days: phenoxymethylpenicillin (PCV), amoxicillin, or doxycycline...
March 2, 2018: Clinical Microbiology and Infection
Hanna Carlsson, Christina Ekerfelt, Anna J Henningsson, Lars Brudin, Ivar Tjernberg
BACKGROUND: Determinants of a subclinical course of Lyme borreliosis (LB) remain largely unknown. The aim of this study was to assess the extent, sex and age profiles of subclinical Borrelia seroconversion in a LB endemic area in Sweden and to map blood cellular Borrelia-specific immune marker patterns in individuals with a previous subclinical LB course compared with patients previously diagnosed with Lyme neuroborreliosis (LNB). METHODS: A large group of 1113 healthy blood donors was screened for multiple IgG anti-Borrelia antibodies and asked to complete a health inquiry regarding previous LB...
February 16, 2018: Ticks and Tick-borne Diseases
A Gryczyńska, T Gortat, M Kowalec
The anticipated worldwide surge in urban environments is generating ever-greater interest in the study of host-pathogen interactions in this specific type of habitat. We investigated the potential of city-inhabiting rodents to serve as the main Lyme borreliosis agents (Borrelia spp.) reservoir. We also tried to verify if anthropogenic disturbances changing the vertebrate species community composition may also alter the scheme of Borrelia spp. circulation. A total of 252 Apodemus mice (A. agrarius, A. flavicollis, A...
March 5, 2018: Epidemiology and Infection
Alen Sekelj, Davorin Đanić
Lyme borreliosis is a vector-borne infectious disease characterized by three disease stages. In the areas endemic for borreliosis, every acute facial palsy indicates serologic testing and implies specific approach to the disease. Th e aim of the study was to identify and confirm the value of acoustic refl ex and House-Brackman (HB) grading scale as prognostic indicators of facial palsy in neuroborreliosis. Th e study included 176 patients with acute facial palsy divided into three groups based on serologic testing: borreliosis, Bell's palsy, and facial palsy caused by herpes simplex virus type 1 (HSV-1)...
September 2017: Acta Clinica Croatica
Franc Strle, Daša Stupica, Petra Bogovič, Paul Visintainer, Gary P Wormser
Doxycycline is highly effective treatment for early neurologic Lyme borreliosis (NLB). Nineteen studies were reviewed to determine if treatment of patients with erythema migrans with other oral antibiotics would increase the risk for developing NLB. In the eight studies that directly compared doxycycline to another antibiotic, the pooled difference indicated a 0.2% greater risk of developing NLB in doxycycline-treated patients (95% CI: -1.0%, +1.4%; P = 0.77), with an estimated heterogeneity of 0.0%, P = 0...
February 2, 2018: Diagnostic Microbiology and Infectious Disease
M M G Leeflang, H C P M van Weert, J W R Hovius, C W Ang, H Sprong
There is no such thing as a perfect diagnostic test and the value of a test depends on the situation in which the test is being used. Here, we discuss two options for dealing with the diagnostic process for Lyme borreliosis in general practice. One option is to manage, treat or refer according to clinical signs and symptoms, in accordance with Dutch practice guidelines. The other option is to use laboratory tests to guide further patient management (treatment or referral). The choice depends on currently unknown factors, such as the pre-test probability of Lyme disease in patients presenting to general practitioners...
2018: Nederlands Tijdschrift Voor Geneeskunde
Benjamin Cull, Maaike E Pietzsch, Kayleigh M Hansford, Emma L Gillingham, Jolyon M Medlock
Public Health England's passive Tick Surveillance Scheme (TSS) records the distribution, seasonality and host associations of ticks submitted from across the United Kingdom (UK), and helps to inform the UK government on emerging tick-borne disease risks. Here we summarise data collected through surveillance during 2010-2016, and compare with previous TSS data from 2005 to 2009, particularly in relation to the primary Lyme borreliosis vector Ixodes ricinus. 4173 records were submitted, constituting >14,000 ticks; 97% were endemic tick records (13,833 ticks of 11 species), with an additional 97 records of imported ticks (438 ticks of 17 species)...
February 3, 2018: Ticks and Tick-borne Diseases
M Zwerink, T P Zomer, B van Kooten, G Blaauw, T van Bemmel, B C van Hees, Y M Vermeeren, G W Landman
A two-step testing strategy is recommended in serological testing for Lyme borreliosis; positive and indeterminate enzyme-linked immunosorbent assay (ELISA) results are confirmed with immunoblots. Several ELISAs quantify the concentration of antibodies tested, however, no recommendation exists for an upper cut-off value at which an IgG ELISA is sufficient and the immunoblot can be omitted. The study objective was to determine at which IgG antibody level an immunoblot does not have any additional predictive value compared to ELISA results...
December 24, 2017: Ticks and Tick-borne Diseases
Sally Mavin, Roger Evans, Thomas Cornulier, Alan S Bowman
OBJECTIVES: Current serological methods cannot distinguish active from past infection with Borrelia burgdorferi sensu lato. The aim of this study was to develop an IgG avidity Western blot and assess its potential to differentiate patients with early and late Lyme borreliosis (LB) i.e. active disease, from those infected in the past. METHODS: An IgG avidity Western blot was developed. Penalized linear discriminant analysis (PLDA) was employed to compare the Western blot/avidity Western blot profiles of an evaluation panel consisting of 75 sera from patients with early (n = 26) and late (n = 24) LB and past infection (n = 25)...
March 2018: Journal of Microbiological Methods
Larry M Bush, Maria T Vazquez-Pertejo
Lyme disease is the most commonly reported tick-borneillness in the United States. Thecausative spirochete, Borrelia burgdorferi is transmitted by 4 species of Ixodes tick species. Over 90% of US cases occur in northeasternstates from Maine to Virginia, and in Wisconsin, Minnesota, and Michigan. Infection also takes place in northern California and Oregon. Lyme borreliosis is also diagnosed in parts of Europe, China, and Japan. The white-footed mouse is the primary animal reservoir for B. burgdorferi in the U...
February 2, 2018: Disease-a-month: DM
Suyane Nayara Garcia Socoloski, Bruno Gomes de Castro, Matheus Dias Cordeiro, Adivaldo Henrique da Fonseca, Marcio Barizon Cepeda, Rafael Romero Nicolino, Luciano Bastos Lopes
Borrelia burgdorferi sensu stricto is the main etiological agent of Lyme disease (LD) in the USA. In Brazil, it is believed that a similar spirochete is the causal agent of the Baggio-Yoshinari syndrome (BYS), a zoonosis also transmitted by ticks, whose clinical manifestations are similar to those of LD. Despite the epidemiological importance, there are no studies reporting the presence and the prevalence of B. burgdorferi among horses in Mato Grosso State. The aim of this study was to detect and measure the frequency of IgG antibodies anti-B...
January 31, 2018: Tropical Animal Health and Production
Katsuki Eguchi, Kazuhumi Tsuzaka, Ichiro Yabe, Hidenao Sasaki
A 56-year-old man was sustained ticks at the left axilla and flank. He did not have a rash. About 3 months after the tick bites, he developed back pain, right leg weakness, right abducens nerve palsy, and left facial palsy. Western blot analysis for serum IgM and IgG antibodies against Borrelia were positive. We diagnosed Lyme borreliosis. The patient was treated with antibiotics and steroids, and the symptoms improved. Our findings demonstrate that, even if erythema migrans is not obvious, neuroborreliosis should be considered when neurological signs, such as multiple cranial nerve palsies, are present...
January 31, 2018: Rinshō Shinkeigaku, Clinical Neurology
Daša Stupica, Maša Velušcek, Rok Blagus, Petra Bogovic, Tereza Rojko, Tjaša Cerar, Franc Strle
Background: Several guidelines advocate the same treatment approaches for both early disseminated Lyme borreliosis, manifested as multiple erythema migrans (EM), and early localized Lyme borreliosis, manifested as solitary EM. Methods: Oral doxycycline (100 mg q12h) was compared on a non-inferiority premise with intravenous ceftriaxone (2 g q24h) for 14 days in 200 adult European patients with multiple EM in an open-label alternate-treatment observational trial performed in a single-centre university hospital...
January 29, 2018: Journal of Antimicrobial Chemotherapy
Juraj Koci, Quentin Bernard, Xiuli Yang, Utpal Pal
In its natural infection cycle, the pathogen of Lyme borreliosis transits between a tick vector and a mammalian host. As relatively a minor fraction of spirochetes transits between the host and the vector precluding their reliable detection at early infection, artificial membrane feeders emerged as useful tools to study roles of spirochete proteins in pathogen entry, persistence, and exit through ticks. Here we report the development of a modified membrane feeder to study the role of a Borrelia burgdorferi surface protein called Lmp1 in spirochete transitions between the murine host and ticks...
January 30, 2018: Scientific Reports
Nicola DI Meo, Chiara Retrosi, Paola Corneli, Giusto Trevisan
No abstract text is available yet for this article.
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
T van Gorkom, S U C Sankatsing, W Voet, D M Ismail, R H Muilwijk, M Salomons, B J M Vlaminckx, A W J Bossink, D W Notermans, J J M Bouwman, K Kremer, S F T Thijsen
Two-tier serology testing is most frequently used for the diagnosis of Lyme borreliosis (LB); however, a positive result is no proof of active disease. To establish a diagnosis of active LB, better diagnostics are needed. Tests investigating the cellular immune system are available, but studies evaluating the utility of these tests on well-defined patient populations are lacking. Therefore, we investigated the utility of an enzyme-linked immunospot (ELISpot) assay to diagnose active Lyme neuroborreliosis. Peripheral blood mononuclear cells (PBMCs) of various study groups were stimulated by using Borrelia burgdorferi strain B31 and various recombinant antigens and subsequently, the number of Borrelia -specific interferon-gamma (IFN-γ) secreting T-cells was measured...
January 24, 2018: Journal of Clinical Microbiology
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