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https://www.readbyqxmd.com/read/29311239/induction-of-il-10-by-borrelia-burgdorferi-is-regulated-by-the-action-of-cd14-dependent-p38-mapk-and-camp-mediated-chromatin-remodeling
#1
Bikash Sahay, Kathleen Bashant, Nicole J Nelson, Rebeca L Patsey, Shiva Kumar Gadila, Rebecca Boohaker, Ashutosh Verma, Klemen Strle, Timothy J Sellati
Host genotype influences the severity of murine Lyme borreliosis, caused by the spirochetal bacterium Borrelia burgdorferi C57BL/6 (B6) mice develop mild, whereas C3H/HeN (C3H) mice develop severe Lyme arthritis. Differential expression of interleukin 10 (IL-10) has long been associated with mouse strain differences in Lyme pathogenesis; however, the underlying mechanism(s) of this genotype-specific IL-10 regulation remained elusive. Herein we reveal a cAMP-mediated mechanism of IL-10 regulation in B6 macrophages that is substantially diminished in C3H macrophages...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29310722/habitat-properties-are-key-drivers-of-borrelia-burgdorferi-s-l-prevalence-in-ixodes-ricinus-populations-of-deciduous-forest-fragments
#2
Steffen Ehrmann, Sanne C Ruyts, Michael Scherer-Lorenzen, Jürgen Bauhus, Jörg Brunet, Sara A O Cousins, Marc Deconchat, Guillaume Decocq, Pieter De Frenne, Pallieter De Smedt, Martin Diekmann, Emilie Gallet-Moron, Stefanie Gärtner, Karin Hansen, Annette Kolb, Jonathan Lenoir, Jessica Lindgren, Tobias Naaf, Taavi Paal, Marcus Panning, Maren Prinz, Alicia Valdés, Kris Verheyen, Monika Wulf, Jaan Liira
BACKGROUND: The tick Ixodes ricinus has considerable impact on the health of humans and other terrestrial animals because it transmits several tick-borne pathogens (TBPs) such as B. burgdorferi (sensu lato), which causes Lyme borreliosis (LB). Small forest patches of agricultural landscapes provide many ecosystem services and also the disservice of LB risk. Biotic interactions and environmental filtering shape tick host communities distinctively between specific regions of Europe, which makes evaluating the dilution effect hypothesis and its influence across various scales challenging...
January 8, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29298961/-actual-guidelines-of-borreliosis-treatment
#3
EDITORIAL
Tadeusz Płusa
The treatment of patients infected with Borrelia burgdorferi was the subject of studies by numerous experts. The discrepancy of the recommendations is quite significant, especially in the choice of antibiotic, which is most important in the first stage of infection. The recommended doxycycline is in all recommendations although its MIC90 is 2.0 mg/L. Other antibiotics have better parameters, especially azithromycin topically administered in the first stage of infection, can be fully effective. In addition to the morphological and immunological variability of Borrelia burgdorferi, antibiotics that have an ability to enter the cell, such as azithromycin, should be noted...
December 22, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29275874/australian-penguin-ticks-screened-for-novel-borrelia-species
#4
Katherine L Moon, Steven L Chown, Siew-May Loh, Charlotte L Oskam, Ceridwen I Fraser
Lyme borreliosis (or Lyme Disease) is an emerging threat to human health in the Northern Hemisphere caused by tick-borne bacteria from the Borrelia burgdorferi sensu lato (Bbsl) complex. Seabirds are important reservoir hosts of some members of the Bbsl complex in the Northern Hemisphere, and some evidence suggests this may be true of penguins in the Southern Hemisphere. While the Bbsl complex has not been detected in Australia, a novel Borrelia species ('Candidatus Borrelia tachyglossi') was recently sequenced from native ticks (Ixodes holocyclus and Bothriocroton concolor) parasitising echidnas (Tachyglossus aculeatus), suggesting unidentified borreliae may be circulating amongst native wildlife and their ticks...
December 15, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29260744/-clinical-presentation-of-ixodes-tick-borne-borreliosis-caused-by-borrelia-miyamotoi-in-the-context-of-an-immune-response-to-the-pathogen
#5
A E Platonov, M G Toporkova, N M Kolyasnikova, O A Stukolova, A S Dolgova, A V Brodovikova, N A Makhneva, L S Karan, J Koetsveld, G A Shipulin, V V Maleev
Ixodes tick-borne borreliosis caused by Borrelia miyamotoi (ITBB-BM) is a previously unknown infectious disease discovered in Russia. AIM: The present study continues the investigation of the clinical features of ITBB-BM in the context of an immune system-pathogen interaction. SUBJECTS AND METHODS: The study enrolled 117 patients with ITBB-BM and a comparison group of 71 patients with Lyme disease (LD) that is ITBB with erythema migrans. All the patients were treated at the New Hospital, Yekateringburg...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29258802/a-molecular-algorithm-to-detect-and-differentiate-human-pathogens-infecting-ixodes-scapularis-and-ixodes-pacificus-acari-ixodidae
#6
Christine B Graham, Sarah E Maes, Andrias Hojgaard, Amy C Fleshman, Sarah W Sheldon, Rebecca J Eisen
The incidence and geographic range of tick-borne illness associated with Ixodes scapularis and Ixodes pacificus have dramatically increased in recent decades. Anaplasmosis, babesiosis, and Borrelia spirochete infections, including Lyme borreliosis, account for tens of thousands of reported cases of tick-borne disease every year. Assays that reliably detect pathogens in ticks allow investigators and public health agencies to estimate the geographic distribution of human pathogens, assess geographic variation in their prevalence, and evaluate the effectiveness of prevention strategies...
December 10, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29258801/diversity-of-borrelia-spirochetes-and-other-zoonotic-agents-in-ticks-from-kyiv-ukraine
#7
Artem Rogovskyy, Maliha Batool, David C Gillis, Patricia J Holman, Igor V Nebogatkin, Yuliya V Rogovska, Maksym S Rogovskyy
Lyme borreliosis (LB) is caused by tick-borne spirochetes of the Borrelia burgdorferi sensu lato complex. LB is the most prevalent vector-borne illness in Ukraine, but current data on the prevalence of LB pathogens in their tick vector, Ixodes ricinus, are lacking. I. ricinus ticks may also carry Borrelia miyamotoi, an emerging relapsing fever group spirochete that has been implicated in human illness. Despite its zoonotic potential, the prevalence of B. miyamotoi in ticks has not been examined in Ukraine. Similarly, data on the prevalence of other important tick-borne pathogens, Anaplasma phagocytophilum, Babesia spp...
December 15, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29251638/correlation-of-reflectance-confocal-microscopy-and-dermatopathology-findings-in-a-case-of-acrodermatitis-chronica-atrophicans
#8
Duygu Gülseren, Lorenzo Cerroni, Rainer Hofmann-Wellenhof, Edith Arzberger
Acrodermatitis chronica atrophicans (ACA) that is characterized by thin, papery dry, translucent, and alopecic patches with visible superficial veins is a late cutaneous manifestation of Lyme borreliosis. Clinical findings, a history of exposure to tick bite, and serology are helpful for the diagnosis of ACA and sometimes a biopsy is performed to rule out other infectious or inflammatory processes. In this study, we report reflectance confocal microscopy (RCM) findings in a case of ACA. RCM examination revealed a flattened surface with broadened skin folds, a flattened dermoepidermal junction with few papillae and less bright basal cells and multiple small bright reflecting spots in the dermis...
November 29, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29246814/neuroborreliosis-and-acute-encephalopathy-the-use-of-cxcl13-as-a-biomarker-in-cns-manifestations-of-lyme-borreliosis
#9
Matthias Karrasch, Volker Fingerle, Katharina Boden, Andreas Darr, Michael Baier, Eberhard Straube, Igor Nenadic
We report the case of an 80-year-old patient with acute onset confusion initially suspected to reflect delirium in incipient Alzheimer's disease. Cerebrospinal fluid tests revealed an unusually severe form of neuroborreliosis, which resolved following antibiotic treatment. This was mirrored in the measurement of CXCL13, which is suggested as a complementary biomarker. Clinical implications for screening, differential diagnosis and treatment are discussed.
December 11, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29231910/-clinical-pictures-of-borreliosis
#10
EDITORIAL
Tadeusz Płusa
Lyme disease occurs in a variety of clinical manifestations, ranging from skin lesions, through musculoskeletal, neurological, and cardiac syndrome, to severe irreversible lesions. Borrelia burgdorferi's organotropy has an impact on the development of the disease. In initial management, it is important to implement effective treatment to prevent further progression of infection. Dominant skin lesions should be differentiated in detail. In the form of disseminated disease complex of clinical syndromes is observed but it requires of confirmation in immunoassays...
November 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29223586/reduction-in-human-lyme-neuroborreliosis-associated-with-a-major-epidemic-among-roe-deer
#11
Nanna Skaarup Andersen, Sigurdur Skarphédinsson, Fredrikke C Knudtzen, Carsten Riis Olesen, Thøger Gorm Jensen, Per Moestrup Jensen
Lyme neuroborreliosis is the most severe clinical manifestation of Lyme borreliosis. In most of Denmark, and also Europe, the overall prevalence of Lyme borreliosis seems to be stabilising. This is not the case on the island of Funen, Denmark, where the number of human Lyme neuroborreliosis cases has markedly declined throughout the last decade. We propose the reason for the decline is a major epidemic among roe deer, killing almost half of their population, resulting in a reduction in the tick population which make it less likely to get a tick bite and therefore to contract Lyme neuroborreliosis...
December 6, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29221707/development-of-a-borreliosis-assay-mannan-coated-polyethylene-sinter-bodies-as-a-new-platform-technology
#12
Mohammed Alasel, Nina Dassinger, Doru Vornicescu, Michael Keusgen
Rapid diagnosis of Lyme borreliosis has been carried out on chemically modified porous polyethylene sinter bodies. Photografting of 2-propenol on sinter body's surface was performed as a first step, introducing active hydroxyl groups as a result of polyalcohol formation. The hydroxyl groups were used for further immobilization and could be linked via 3-aminopropyltriethoxysilane (APTES) to polysaccharides like mannan. Prone to coupling, mannan was activated using N, N'-disuccinimidyl carbonate (DSC) to allow smooth reaction with the primary amine groups of the silane layer...
December 5, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29206879/climate-change-influences-on-the-potential-geographic-distribution-of-the-disease-vector-tick-ixodes-ricinus
#13
Abdelghafar A Alkishe, A Townsend Peterson, Abdallah M Samy
BACKGROUND: Ixodes ricinus is a species of hard tick that transmits several important diseases in Europe and North Africa, including Lyme borreliosis and tick-borne encephalitis. Climate change is affecting the geographic distributions and abundances of arthropod vectors, which in turn influence the geographic distribution and epidemiology of associated vector-borne diseases. To date, few studies have investigated effects of climate change on the spatial distribution of I. ricinus at continental extents...
2017: PloS One
https://www.readbyqxmd.com/read/29205927/areolar-lymphocytoma-in-a-child-a-rare-cutaneous-presentation-of-borreliosis
#14
Chikara Ogimi, Claudia Crowell, Markus D Boos
Lyme disease is a common tick-borne infection caused by Borrelia burgdorferi in the United States, where infection is most prevalent in the northeastern and mid-Atlantic states. Although classically associated with erythema migrans, Lyme disease caused by Borrelia species found in Europe may also present with other cutaneous findings. Here we report the case of a girl who was clinically diagnosed with Lyme disease based on her history of recent travel and the appearance of an areolar lymphocytoma; this was confirmed by testing...
December 4, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29202704/prevention-of-tick-bites-an-evaluation-of-a-smartphone-app
#15
L Antonise-Kamp, D J M A Beaujean, R Crutzen, J E van Steenbergen, D Ruwaard
BACKGROUND: Lyme borreliosis (LB) is the most common reported tick-borne infection in Europe, and involves transmission of Borrelia by ticks. As long as a vaccine is not available and effective measures for controlling tick populations are insufficient, LB control is focused on preventive measures to avoid tick bites. To inform citizens about the risk of ticks, motivate them to check for tick bites, and encourage them to remove any attached tick as quickly as possible, a mobile app called 'Tekenbeet' (Dutch for 'tick bite') was developed and released...
December 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29196626/identification-of-borrelia-protein-candidates-in-mouse-skin-for-potential-diagnosis-of-disseminated-lyme-borreliosis
#16
Antoine Grillon, Benoît Westermann, Paola Cantero, Benoît Jaulhac, Maarten J Voordouw, Delphine Kapps, Elody Collin, Cathy Barthel, Laurence Ehret-Sabatier, Nathalie Boulanger
In vector-borne diseases, the skin plays an essential role in the transmission of vector-borne pathogens between the vertebrate host and blood-feeding arthropods and in pathogen persistence. Borrelia burgdorferi sensu lato is a tick-borne bacterium that causes Lyme borreliosis (LB) in humans. This pathogen may establish a long-lasting infection in its natural vertebrate host where it can persist in the skin and some other organs. Using a mouse model, we demonstrate that Borrelia targets the skin regardless of the route of inoculation, and can persist there at low densities that are difficult to detect via qPCR, but that were infective for blood-feeding ticks...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29190743/crystal-structure-of-a-tripartite-complex-between-c3dg-c-terminal-domains-of-factor-h-and-ospe-of-borrelia-burgdorferi
#17
Robert Kolodziejczyk, Kornelia M Mikula, Tommi Kotila, Vincent L G Postis, T Sakari Jokiranta, Adrian Goldman, Taru Meri
Complement is an important part of innate immunity. The alternative pathway of complement is activated when the main opsonin, C3b coats non-protected surfaces leading to opsonisation, phagocytosis and cell lysis. The alternative pathway is tightly controlled to prevent autoactivation towards host cells. The main regulator of the alternative pathway is factor H (FH), a soluble glycoprotein that terminates complement activation in multiple ways. FH recognizes host cell surfaces via domains 19-20 (FH19-20). All microbes including Borrelia burgdorferi, the causative agent of Lyme borreliosis, must evade complement activation to allow the infectious agent to survive in its host...
2017: PloS One
https://www.readbyqxmd.com/read/29181672/seasonal-cycles-of-the-tbe-and-lyme-borreliosis-vector-ixodes-ricinus-modelled-with-time-lagged-and-interval-averaged-predictors
#18
Katharina Brugger, Melanie Walter, Lidia Chitimia-Dobler, Gerhard Dobler, Franz Rubel
Ticks of the species Ixodes ricinus (L.) are the major vectors for tick-borne diseases in Europe. The aim of this study was to quantify the influence of environmental variables on the seasonal cycle of questing I. ricinus. Therefore, an 8-year time series of nymphal I. ricinus flagged at monthly intervals in Haselmühl (Germany) was compiled. For the first time, cross correlation maps were applied to identify optimal associations between observed nymphal I. ricinus densities and time-lagged as well as temporal averaged explanatory variables...
November 27, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/29153461/population-based-borrelia-burgdorferi-sensu-lato-seroprevalence-and-associated-risk-factors-in-finland
#19
Janko van Beek, Eeva Sajanti, Otto Helve, Jukka Ollgren, Mikko J Virtanen, Harri Rissanen, Outi Lyytikäinen, Jukka Hytönen, Jussi Sane
Lyme borreliosis (LB) is caused by Borrelia burgdorferi sensu lato (Bb-sl) and is the most common vector-borne disease in Europe. The objectives of this study were to determine the Bb-sl seroprevalence among the general Finnish adult population and to identify risk factors associated with Bb-sl-seropositive status. Two thousand sera from a nationwide health survey from 2011 were tested by whole-cell sonicate IgG ELISA, C6 peptide ELISA, and recomBead IgG 2.0 and test results were linked to a general health questionnaire...
November 11, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29151040/meningoencephalitis-in-a-royal-marine-after-skinning-reindeer-in-norway
#20
Christopher A Pollard, D S Burns, B Ho, A McD Johnston
Meningoencephalitis presenting in service personnel overseas may present a diagnostic challenge due to the broad range of potential differential diagnosis as well as the requirement for rapid assessment and treatment. A 25-year-old Royal Marine was evacuated to the Royal Centre for Defence Medicine in Birmingham, UK, with a history of rash consistent with erythema chronicum migrans, a seizure, and lymphocytic pleocytosis after skinning reindeer in Norway. Neuroborreliosis was suspected and empirical antibiotics were administered...
November 18, 2017: Journal of the Royal Army Medical Corps
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