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https://www.readbyqxmd.com/read/28077149/plasmodium-falciparum-malaria-co-infection-with-tick-borne-relapsing-fever-in-dakar
#1
Mamadou A Diallo, Baidy S Kane, Mouhamadou Ndiaye, Mouhamed Dieng, Khadim Diongue, Aida S Badiane, Mame Cheikh Seck, Daouda Ndiaye
BACKGROUND: West African tick-borne relapsing fever (TBRF) due to Borrelia crocidurae and malaria are co-endemics in Senegal. Although expected to be high, co-infections are rarely reported. A case of falciparum malaria and B. crocidurae co-infection in a patient from Velingara (South of Senegal) is discussed. CASE: A 28 year-old-male patient presented to Aristide Le Dantec Hospital for recurrent fever. He initially presented to a local post health of Pikine (sub-urban of Dakar) and was diagnosed for malaria on the basis of positive malaria rapid diagnostic test (RDT) specific to Plamodium falciparum...
January 11, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28065617/borrelia-miyamotoi-in-vectors-and-hosts-in-the-netherlands
#2
Alex Wagemakers, Seta Jahfari, Bob de Wever, Lodewijk Spanjaard, Markus V Starink, Henry J C de Vries, Hein Sprong, Joppe W Hovius
Ixodes ticks transmit Borrelia burgdorferi sensu lato (s.l.), the causative agent of Lyme borreliosis (LB). These tick species also transmit Borrelia miyamotoi, which was recently found to cause infections in humans. We were interested in the prevalence of B. miyamotoi infection in ticks and natural hosts in The Netherlands, and to what extent ticks are co-infected with B. burgdorferi. In addition, erythema migrans has been sporadically described in B. miyamotoi-infected patients, but these skin lesions might as well represent co-infections with B...
December 30, 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28055580/diagnosing-borreliosis
#3
Sally J Cutler, Nataliia Rudenko, Maryna Golovchenko, Wibke J Cramaro, Josiane Kirpach, Sara Savic, Iva Christova, Ana Amaro
Borrelia species fall into two groups, the Borrelia burgdorferi sensu lato (Bbsl) complex, the cause of Lyme borreliosis (also known as Lyme disease), and the relapsing fever group. Both groups exhibit inter- and intraspecies diversity and thus have variations in both clinical presentation and diagnostic approaches. A further layer of complexity is derived from the fact that ticks may carry multiple infectious agents and are able to transmit them to the host during blood feeding, with potential overlapping clinical manifestations...
January 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28054584/inefficient-co-feeding-transmission-of-borrelia-afzelii-in-two-common-european-songbirds
#4
Dieter J A Heylen, Hein Sprong, Aleksandra Krawczyk, Natalie Van Houtte, Dolores Genné, Andrea Gomez-Chamorro, Kees van Oers, Maarten J Voordouw
The spirochete bacterium Borrelia afzelii is the most common cause of Lyme borreliosis in Europe. This tick-borne pathogen can establish systemic infections in rodents but not in birds. However, several field studies have recovered larval Ixodes ricinus ticks infected with B. afzelii from songbirds suggesting successful transmission of B. afzelii. We reviewed the literature to determine which songbird species were the most frequent carriers of B. afzelii-infected I. ricinus larvae and nymphs. We tested experimentally whether B...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28049383/a-lyme-borreliosis-diagnosis-probability-score-no-relation-with-antibiotic-treatment-response
#5
Violeta T Briciu, Mirela Flonta, Daniel Leucuţa, Dumitru Cârstina, Doina F Ţăţulescu, Mihaela Lupşe
OBJECTIVES: (1) To describe epidemiological and clinical data of patients that present with the suspicion of Lyme borreliosis (LB); (2) to evaluate a previous published score that classifies patients on the probability of having LB, following-up patients' clinical outcome after antibiotherapy. METHODS: Inclusion criteria: patients with clinical manifestations compatible with LB and Borrelia (B.) burgdorferi positive serology, hospitalized in a Romanian hospital between January 2011 and October 2012...
January 3, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28040562/enzootic-origins-for-clinical-manifestations-of-lyme-borreliosis
#6
Setareh Jahfari, Aleksandra Krawczyk, E Claudia Coipan, Manoj Fonville, Joppe W Hovius, Hein Sprong, Katsuhisa Takumi
Both early localized and late disseminated forms of Lyme borreliosis are caused by Borrelia burgdorferi senso lato. Differentiating between the spirochetes that only cause localized skin infection from those that cause disseminated infection, and tracing the group of medically-important spirochetes to a specific vertebrate host species, are two critical issues in disease risk assessment and management. Borrelia burgdorferi senso lato isolates from Lyme borreliosis cases with distinct clinical manifestations (erythema migrans, neuroborreliosis, acrodermatitis chronica atrophicans, and Lyme arthritis) and isolates from Ixodes ricinus ticks feeding on rodents, birds and hedgehogs were typed to the genospecies level by sequencing part of the intergenic spacer region...
December 28, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28035112/the-incidence-of-borrelia-burgdorferi-anaplasma-phagocytophilum-and-babesia-microti-coinfections-among-foresters-and-farmers-in-eastern-poland
#7
Anna Pañczuk, Małgorzata Tokarska-Rodak, Maria Kozioł-Montewka, Dorota Plewik
BACKGROUND & OBJECTIVES: Lyme borreliosis is the most common tick-borne disease in Europe and the USA. However, a great variety of pathogens are transmitted by ticks, which results in mixed infections, with Lyme borreliosis. The aim of the present study was to show the incidence of Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti coinfections among the population of foresters and farmers, as these people, due to their profession, are particularly exposed to tick contact...
October 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28030649/whole-genome-sequence-and-comparative-genomics-of-the-novel-lyme-borreliosis-causing-pathogen-borrelia-mayonii
#8
Luke C Kingry, Dhwani Batra, Adam Replogle, Lori A Rowe, Bobbi S Pritt, Jeannine M Petersen
Borrelia mayonii, a Borrelia burgdorferi sensu lato (Bbsl) genospecies, was recently identified as a cause of Lyme borreliosis (LB) among patients from the upper midwestern United States. By microscopy and PCR, spirochete/genome loads in infected patients were estimated at 105 to 106 per milliliter of blood. Here, we present the full chromosome and plasmid sequences of two B. mayonii isolates, MN14-1420 and MN14-1539, cultured from blood of two of these patients. Whole genome sequencing and assembly was conducted using PacBio long read sequencing (Pacific Biosciences RSII instrument) followed by hierarchical genome-assembly process (HGAP)...
2016: PloS One
https://www.readbyqxmd.com/read/28017623/pathogenetic-implications-of-the-age-at-time-of-diagnosis-and-skin-location-for-acrodermatitis-chronica-atrophicans
#9
Katarina Ogrinc, Gary P Wormser, Paul Visintainer, Vera Maraspin, Stanka Lotrič-Furlan, Jože Cimperman, Eva Ružić-Sabljić, Petra Bogovič, Tereza Rojko, Daša Stupica, Franc Strle
BACKGROUND: The pathogenesis of acrodermatitis chronica atrophicans (ACA) is not well understood. OBJECTIVE: The purpose of this study was to gain a better understanding of ACA by utilizing a large data set of adult Slovenian patients with Lyme borreliosis. METHODS: The age of 590 ACA patients was compared with that of patients with other manifestations of Lyme borreliosis. The location of the ACA lesion on the body was compared with that of erythema migrans (EM)...
November 24, 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28007428/topical-azithromycin-for-the-prevention-of-lyme-borreliosis-a-randomised-placebo-controlled-phase-3-efficacy-trial
#10
Michael Schwameis, Thomas Kündig, Gustave Huber, Luzi von Bidder, Lorenz Meinel, Roland Weisser, Elisabeth Aberer, Georg Härter, Thomas Weinke, Tomas Jelinek, Gerd Fätkenheuer, Uwe Wollina, Gerd-Dieter Burchard, Roland Aschoff, Ruth Nischik, Gerhard Sattler, Georg Popp, Wolfgang Lotte, Dirk Wiechert, Gerald Eder, Olga Maus, Petra Staubach-Renz, Andrea Gräfe, Veronika Geigenberger, Ingomar Naudts, Michael Sebastian, Norbert Reider, Ridwan Weber, Marc Heckmann, Emil C Reisinger, Georg Klein, Johannes Wantzen, Bernd Jilma
BACKGROUND: Lyme borreliosis develops in 1-5% of individuals bitten by ticks, but with a diagnostic gap affecting up to 30% of patients, a broadly applicable pharmacological prevention strategy is needed. Topical azithromycin effectively eradicated Borrelia burgdorferi sensu lato from the skin in preclinical studies. We assessed its efficacy in human beings. METHODS: In this randomised, double-blind, placebo-controlled, multicentre trial done in 28 study sites in Germany and Austria, adults were equally assigned to receive topical 10% azithromycin or placebo twice daily for 3 consecutive days, within 72 h of a tick bite being confirmed...
December 19, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28007427/prophylaxis-with-topical-azithromycin-against-lyme-borreliosis
#11
Eugene D Shapiro, Gary P Wormser
No abstract text is available yet for this article.
December 19, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28005032/-tick-borne-neuroinfections-clinical-characteristics-immunopathogenesis-and-new-pharmacotherapeutic-strategies
#12
A B Kon'kova-Reidman
AIM: To study the semiotics of neurological lesions in patients with tick-borne encephalitis, Ixodes tick-borne borreliosis (ITBB) and mixed infection (MI), their immunopathogenesis, and the possibilities of current pathogenetic pharmacological correction. SUBJECTS AND METHODS: A total of 220 patients with tick-borne encephalitis, ITBB, and MI concurrent with the syndromes of central nervous system lesions were examined. The immunological studies encompassed the examination of mononuclear cells in the cerebrospinal fluid (CSF), the population and subpopulation composition of lymphocytes, and nitroxidergic processes in the serum and CSF from the total level of final stable nitric oxide metabolites...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28005031/-follow-up-of-patients-with-ixodes-tick-borne-borrelioses-caused-by-borrelia-miyamotoi-or-borrelia-burgdorferi-sensu-lato
#13
L I Bagautdinova, A E Platonov, D S Sarksyan, O V Stukolova, G A Shipulin, V V Maleev, M V Dudarev
: Ixodes tick-borne borrelioses (ITBB) are caused by two different spirochetes: Borrelia from the group of Borrelia burgdorferi sensu lato, the agents of the classic Lyme borreliosis (LB), and Borrelia miyamotoi that belongs to the group of Borrelia causing tick-borne relapsing fevers. ITBB caused by B. miyamotoi (BM-ITBB) is a previously unknown infectious disease discovered in Russia. It is known that the LB sequelae may reduce the long-term life guality of convalescents. AIM: To study the follow-up of those who have recovered from new BM-ITBB infection in comparison with persons who have had LB...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27995301/borrelia-miyamotoi-and-co-infection-with-borrelia-afzelii-in-ixodes-ricinus-ticks-and-rodents-from-slovakia
#14
Zuzana Hamšíková, Claudia Coipan, Lenka Mahríková, Lenka Minichová, Hein Sprong, Mária Kazimírová
Borrelia miyamotoi causes relapsing fever in humans. The occurrence of this spirochete has been reported in Ixodes ricinus and wildlife, but there are still gaps in the knowledge of its eco-epidemiology and public health impact. In the current study, questing I. ricinus (nymphs and adults) and skin biopsies from rodents captured in Slovakia were screened for the presence of B. miyamotoi and Borrelia burgdorferi s.l. DNA. The prevalence of B. miyamotoi and B. burgdorferi s.l. in questing ticks was 1.7 and 16...
December 19, 2016: Microbial Ecology
https://www.readbyqxmd.com/read/27986402/the-domestic-pig-as-a-potential-model-for-borrelia-skin-infection
#15
Michael Reiter, Christian Knecht, Andreas Müller, Anna-Margarita Schötta, Michael Leschnik, Michiel Wijnveld, Herbert Weissenböck, Hannes Stockinger, Gerold Stanek, Wolfgang Sipos
The skin lesion erythema migrans is a characteristic early manifestation of Lyme borreliosis in humans. However, the pathomechanisms leading to development of this erythema are not fully understood. Models that mimic human skin would enhance research in this field. Human and porcine skin structures strongly resemble each other. Therefore, we attempted to induce erythema migrans lesions in experimental Borrelia burgdorferi sensu lato infection in the skin of domestic pigs. The formation of erythema migrans-like lesions was observed after intradermal injection of these spirochetes, with the lesions forming very clearly in 2/6 animals when a strain of B...
December 7, 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/27977689/tick-borne-diseases-in-turkey-a-review-based-on-one-health-perspective
#16
REVIEW
Abdullah Inci, Alparslan Yildirim, Onder Duzlu, Mehmet Doganay, Serap Aksoy
The importance of tick-borne diseases is increasing all over the world, including Turkey. Global warming, environmental and ecological changes and the existence of suitable habitats increase the impact of ticks and result in frequent emergence or re-emergence of tick-borne diseases (TBDs) with zoonotic characteristics. In Turkey, almost 19 TBDs have been reported in animals and men, involving four protozoa (babesiosis, theileriosis, cytauxzoonosis, hepatozoonosis), one filarial nematode (acanthocheilonemasis), ten bacterial agents (anaplasmosis, ehrlichiosis, aegyptianellosis, tick-borne typhus, Candidatus Rickettsia vini, Lyme borreliosis, tick-borne relapsing fever [TBRF], tularaemia, bartonellosis, and hemoplasmosis), and four viral infections (tick-borne encephalitis [TBE], Crimean-Congo Haemorrhagic Fever [CCHF], louping-ill [LI], and lumpy skin disease [LSD])...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27976670/lyme-borreliosis
#17
Allen C Steere, Franc Strle, Gary P Wormser, Linden T Hu, John A Branda, Joppe W R Hovius, Xin Li, Paul S Mead
Lyme borreliosis is a tick-borne disease that predominantly occurs in temperate regions of the northern hemisphere and is primarily caused by the bacterium Borrelia burgdorferi in North America and Borrelia afzelii or Borrelia garinii in Europe and Asia. Infection usually begins with an expanding skin lesion, known as erythema migrans (referred to as stage 1), which, if untreated, can be followed by early disseminated infection, particularly neurological abnormalities (stage 2), and by late infection, especially arthritis in North America or acrodermatitis chronica atrophicans in Europe (stage 3)...
December 15, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27974742/lyme-borreliosis
#18
(no author information available yet)
No abstract text is available yet for this article.
December 15, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27970586/mathematical-model-to-synthesize-natural-history-of-tick-borne-encephalitis-and-lyme-borreliosis-for-the-purpose-of-cost-effectiveness-analysis
#19
J Mihajlovic, J W Hovius, H Sprong, F Strle, P Bogovic, M J Postma
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27922168/update-of-the-swiss-guidelines-on-post-treatment-lyme-disease-syndrome
#20
Johannes Nemeth, Enos Bernasconi, Ulrich Heininger, Mohamed Abbas, David Nadal, Carol Strahm, Stefan Erb, Stefan Zimmerli, Hansjakob Furrer, Julie Delaloye, Thierry Kuntzer, Ekkehard Altpeter, Mathias Sturzenegger, Rainer Weber, For The Swiss Society For Infectious Diseases And The Swiss Society For Neurology
Lyme borreliosis is caused by Borrelia burgdorferi sensu lato infection, which responds well to antibiotic therapy in the overwhelming majority of cases. However, despite adequate antibiotic treatment some patients report persisting symptoms which are commonly summarised as post-treatment Lyme disease syndrome (PTLDS). In 2005, the Swiss Society of Infectious Diseases published a case definition for PTLDS. We aimed to review the scientific literature with a special emphasis on the last 10 years, questioning whether the definitions from 2005 are still valid in the light of current knowledge...
2016: Swiss Medical Weekly
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