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https://www.readbyqxmd.com/read/28735651/the-effect-of-artesunate-on-short-term-memory-in-lyme-borreliosis
#1
B K Puri, J S Hakkarainen-Smith, J A Monro
Lyme borreliosis is associated with memory deficits. While this may be related to cerebral infection by Borrelia bacteria, it may also be caused by concomitant co-infection by Babesia protozoa. The anti-malarial artemisinin-derivative artesunate has been shown to be effective against a number of Babesia species and to have efficacy against human cerebral malaria. We hypothesised that concomitant administration of artesunate in Lyme borreliosis patients would help alleviate the severity of self-reported short-term memory impairment...
August 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28726624/lyme-borreliosis-in-finland-1995-2014
#2
Eeva Sajanti, Mikko Virtanen, Otto Helve, Markku Kuusi, Outi Lyytikäinen, Jukka Hytönen, Jussi Sane
We investigated the epidemiology of Lyme borreliosis (LB) in Finland for the period 1995-2014 by using data from 3 different healthcare registers. We reviewed data on disseminated LB cases from the National Infectious Diseases Register (21,051 cases) and the National Hospital Discharge Register (10,402 cases) and data on primary LB (erythema migrans) cases from the Register for Primary Health Care Visits (11,793 cases). Incidence of microbiologically confirmed disseminated LB cases increased from 7/100,000 population in 1995 to 31/100,000 in 2014...
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28714333/-borrelia-miyamotoi-a-recently-identified-human-pathogenic-tick-borne-relapsing-fever-spirochete
#3
Sándor Szekeres, András Lakos, Gábor Földvári
Borrelia miyamotoi is a recently described relapsing fever spirochete transmitted by ticks of the Ixodes ricinus complex. This pathogen is different from Borrelia burgdorferi sensu lato (the Lyme borreliosis spirochetes) in its epidemiology, ecology and also genetics. Over 50 patients have been described worldwide with Borrelia miyamotoi disease, and three immunocompromised patients were reported with neurological symptoms. Our knowledge about Borrelia miyamotoi infection in ticks and its distribution in different habitats and also the mechanism of the infection is limited...
July 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28705983/completed-genome-sequences-of-borrelia-burgdorferi-sensu-stricto-b31-nrz-and-closely-related-patient-isolates-from-europe
#4
Gabriele Margos, Sabrina Hepner, Christoph Mang, Andreas Sing, Bernhard Liebl, Volker Fingerle
Borrelia burgdorferi sensu stricto is a causative agent of human Lyme borreliosis in the United States and Europe. We report here the completed genome sequences of strain B31 isolated from a tick in the United States and two closely related strains from Europe, PAli and PAbe, which were isolated from patients with erythema migrans and neuroborreliosis, respectively.
July 13, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28703098/surveillance-perspective-on-lyme-borreliosis-across-the-european-union-and-european-economic-area
#5
Cees C van den Wijngaard, Agnetha Hofhuis, Mariana Simões, Ente Rood, Wilfrid van Pelt, Herve Zeller, Wim Van Bortel
Lyme borreliosis (LB) is the most prevalent tick-borne disease in Europe. Erythema migrans (EM), an early, localised skin rash, is its most common presentation. Dissemination of the bacteria can lead to more severe manifestations including skin, neurological, cardiac, musculoskeletal and ocular manifestations. Comparison of LB incidence rates in the European Union (EU)/European Economic Area (EEA) and Balkan countries are difficult in the absence of standardised surveillance and reporting procedures. We explored six surveillance scenarios for LB surveillance in the EU/EEA, based on the following key indicators: (i) erythema migrans, (ii) neuroborreliosis, (iii) all human LB manifestations, (iv) seroprevalence, (v) tick bites, and (vi) infected ticks and reservoir hosts...
July 6, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28694446/ticks-infected-via-co-feeding-transmission-can-transmit-lyme-borreliosis-to-vertebrate-hosts
#6
Alessandro Belli, Anouk Sarr, Olivier Rais, Ryan O M Rego, Maarten J Voordouw
Vector-borne pathogens establish systemic infections in host tissues to maximize transmission to arthropod vectors. Co-feeding transmission occurs when the pathogen is transferred between infected and naive vectors that feed in close spatiotemporal proximity on a host that has not yet developed a systemic infection. Borrelia afzelii is a tick-borne spirochete bacterium that causes Lyme borreliosis (LB) and is capable of co-feeding transmission. Whether ticks that acquire LB pathogens via co-feeding are actually infectious to vertebrate hosts has never been tested...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28690096/modeling-the-effects-of-variable-feeding-patterns-of-larval-ticks-on-the-transmission-of-borrelia-lusitaniae-and-borrelia-afzelii
#7
Luca Ferreri, Silvia Perazzo, Ezio Venturino, Mario Giacobini, Luigi Bertolotti, Alessandro Mannelli
Spirochetes belonging to the Borrelia burgdoferi sensu lato (sl) group cause Lyme Borreliosis (LB), which is the most commonly reported vector-borne zoonosis in Europe. B. burgdorferi sl is maintained in nature in a complex cycle involving Ixodes ricinus ticks and several species of vertebrate hosts. The transmission dynamics of B. burgdorferi sl is complicated by the varying competence of animals for different genospecies of spirochetes that, in turn, vary in their capability of causing disease. In this study, a set of difference equations simplifying the complex interaction between vectors and their hosts (competent and not for Borrelia) is built to gain insights into conditions underlying the dominance of B...
July 6, 2017: Theoretical Population Biology
https://www.readbyqxmd.com/read/28676442/a-biochip-based-combined-immunoassay-for-detection-of-serological-status-of-borrelia-burgdorferi-in-lyme-borreliosis
#8
Na-Li Huang, Lei Ye, Hui Lv, Yi-Xin Du, Marion Schneider, Li-Bin Fan, Wei-Dong Du
BACKGROUND: Dithiobis (succinimidyl undecanoate) modified gold surface biochip were used as a combined immunoassay platform for concurrently detecting immune responses to Borrelia burgdorferi (B. burgdorferi) sensu lato antigens, flagellin, outer surface protein C, variable major protein-like sequence proteins, and 3 VlsE protein IR6 peptides. The peptides represented intrinsic Borrelia genospecies: B. burgdorferi sensu stricto, B. garinii, and B. afzelii, respectively. METHODS: Fourier transform infrared spectroscopy was utilized to validate the surface chemical characteristics on the modified gold surface...
July 1, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28674060/in-vitro-susceptibility-of-the-relapsing-fever-spirochete-borrelia-miyamotoi-to-antimicrobial-agents
#9
Joris Koetsveld, Ronald O P Draga, Alex Wagemakers, Annemijn Manger, Anneke Oei, Caroline E Visser, Joppe W Hovius
Hard tick-borne relapsing fever (HTBRF) is an emerging infectious disease throughout the temperate zone caused by the relapsing fever spirochete Borrelia miyamotoi Antibiotic treatment of HTBRF is empirically based on the treatment of Lyme borreliosis, however antibiotic susceptibility of B. miyamotoi has not been studied to date. Thus, we set out to determine the in vitro antimicrobial susceptibility of B. miyamotoiA microdilution method with 96-well microtiter plates was used to determine antibiotic susceptibility of two B...
July 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28656405/-lyme-borreliosis-after-tick-bite-when-to-consider-the-diagnosis-lyme-borreliosis
#10
REVIEW
Heidelore Hofmann
No abstract text is available yet for this article.
June 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28655322/interaction-of-primary-mast-cells-with-borrelia-burgdorferi-sensu-stricto-role-in-transmission-and-dissemination-in-c57bl-6-mice
#11
Quentin Bernard, Zhenping Wang, Anna Di Nardo, Nathalie Boulanger
BACKGROUND: Borrelia burgdorferi (sensu lato), the causative agent of Lyme borreliosis is a bacterium transmitted by hard ticks, Ixodes spp. Bacteria are injected into the host skin during the tick blood meal with tick saliva. There, Borrelia and saliva interact together with skin cells such as keratinocytes, fibroblasts, mast cells and other specific immune cells before disseminating to target organs. METHODS: To study the role of mast cells in the transmission of Lyme borreliosis, we isolated mouse primary mast cells from bone marrow and incubated them in the presence of Borrelia burgdorferi (sensu stricto) and tick salivary gland extract...
June 27, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28649922/in-vivo-imaging-of-lyme-arthritis-in-mice-by-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#12
A Pietikäinen, R Siitonen, H Liljenbäck, O Eskola, M Söderström, A Roivainen, J Hytönen
OBJECTIVE: Lyme borreliosis (LB) is a tick-borne infectious disease caused by Borrelia burgdorferi spirochaetes, which are able to disseminate from the tick-bite site to distant organs. Mouse models are widely used to study LB and especially Lyme arthritis (LA), but only a few whole-animal in vivo imaging studies on the pathogenesis of B. burgdorferi infection in mice have been published so far. The existing imaging techniques have their drawbacks and, therefore, novel tools to complement the array of available LB imaging methodologies are needed...
June 26, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28648773/the-burden-of-tick-borne-diseases-in-the-altai-region-of-russia
#13
V G Dedkov, E G Simonova, O V Beshlebova, M V Safonova, O A Stukolova, E V Verigina, G V Savinov, I P Karaseva, E A Blinova, V M Granitov, I V Arsenjeva, G A Shipulin
This article presents the results of a comprehensive survey of the burden of tick-borne infectious diseases (TBIDs) in the Altai region of Russia. Official data for TBID incidence were analyzed and 201 samples from patients with suspected TBID were studied. Furthermore, questing ticks and ticks recovered from humans were examined to estimate prevalence of TBID-causative agents. The Altai region was determined to have a heightened risk for TBIDs in Russia. The most epidemiologically significant tick-borne illness in this area is spotted fever group rickettsiosis, while nationally in Russia, the leading TBID is Lyme borreliosis...
August 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28616477/is-there-a-lyme-like-disease-in-australia-summary-of-the-findings-to-date
#14
REVIEW
Melissa Judith Chalada, John Stenos, Richard Stewart Bradbury
Lyme Borreliosis is a common tick-borne disease of the northern hemisphere caused by the spirochaetes of the Borrelia burgdorferi sensu lato (B. burgdorferi s. l.) complex. It results in multi-organ disease with arthritic, cardiac, neurological and dermatological manifestations. In the last twenty-five years there have been over 500 reports of an Australian Lyme-like syndrome in the scientific literature. However, the diagnoses of Lyme Borreliosis made in these cases have been primarily by clinical presentation and laboratory results of tentative reliability and the true cause of these illnesses remains unknown...
December 2016: One Health
https://www.readbyqxmd.com/read/28612350/blood-donor-borrelia-burgdorferi-sensu-lato-seroprevalence-and-history-of-tick-bites-at-a-northern-limit-of-the-vector-distribution
#15
Dag Hvidsten, Liisa Mortensen, Bjørn Straume, Mirjana Grujic Arsenovic, Anne-Berit Pedersen, Gro Lyngås, Jeremy S Gray, Nils Grude
In order to study the antibody seroprevalence of the causal agent of Lyme borreliosis, Borrelia burgdorferi sensu lato (s.l.), and the history of tick bites at a geographical distribution limit of Ixodes ricinus, we compared healthy blood donors in geographically extreme regions: the borreliosis-endemic Vestfold County (59°N) and the region of northern Norway. Blood samples were screened using IgG/VlsE ELISA, and positive/borderline samples were confirmed using C6 ELISA and immunoblot assays. Also, donors completed a questionnaire consisting of several items including the places they have lived, and whether they owned any pets...
June 14, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28608042/-granulomatous-reaction-pattern-of-the-skin-interstitial-granulomatous-dermatitis-lymphoma-vasculitis
#16
REVIEW
C Rose, K Holl-Ulrich
A particular diagnostic situation in the classification of a granulomatous dermatitis results when no circumscribed granulomas but instead a diffuse interstitial histiocytic inflammatory infiltrate, a granulomatous vasculitis or a neoplastic lymphocytic infiltrate is found. Interstitial granulomatous dermatitis was originally described in patients with arthritis. Later, it was recognized that there are also associations with other usually immunological diseases. Differentiating between interstitial granulomatous dermatitis and the interstitial form of granuloma annulare, early morphea and variants of borreliosis or scleromyxedema as well as interstitial granulomatous drug reaction can be very difficult...
June 12, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28583197/no-evidence-of-borrelia-mayonii-in-an-endemic-area-for-lyme-borreliosis-in-france
#17
Pierre H Boyer, Sylvie J De Martino, Yves Hansmann, Laurence Zilliox, Nathalie Boulanger, Benoît Jaulhac
BACKGROUND: Borrelia mayonii is currently the latest species belonging to the Borrelia burgdorferi (sensu lato) complex to be discovered. Interestingly it is involved in human pathology causing a high fever. We looked for its presence in post- tick bite febrile patients as well as in Ixodes ricinus ticks in an endemic area of France. RESULTS: After ensuring that our molecular technics correctly detected B. mayonii, 575 patients and 3,122 Ixodes ricinus nymphs were tested...
June 5, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28579253/molecular-evidence-of-borrelia-burgdorferi-sensu-lato-in-patients-in-brazilian-central-western-region
#18
Fernando Aguilar Lopes, Jania de Rezende, Danielly Beraldo Dos Santos Silva, Fernanda de Cássia Gonçalves Alves, Carina Elisei de Oliveira, Izaías Pereira da Costa
We aimed to detect DNA of Borrelia burgdorferi in whole blood and serum samples of patients with clinical symptoms and epidemiology compatible with Brazilian Lyme-like disease. Four patients with positive epidemiological histories were recruited for the study. Blood samples were collected, screened by serologic testing by ELISA and Western blotting and molecular identification of B. burgdorferi by amplifying a fragment of the conserved gene that synthesizes the hook flagellar flgE. The results showed positive serology and for the first time, the presence of B...
June 2, 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28558786/lost-in-plasmids-next-generation-sequencing-and-the-complex-genome-of-the-tick-borne-pathogen-borrelia-burgdorferi
#19
G Margos, S Hepner, C Mang, D Marosevic, S E Reynolds, S Krebs, A Sing, M Derdakova, M A Reiter, V Fingerle
BACKGROUND: Borrelia (B.) burgdorferi sensu lato, including the tick-transmitted agents of human Lyme borreliosis, have particularly complex genomes, consisting of a linear main chromosome and numerous linear and circular plasmids. The number and structure of plasmids is variable even in strains within a single genospecies. Genes on these plasmids are known to play essential roles in virulence and pathogenicity as well as host and vector associations. For this reason, it is essential to explore methods for rapid and reliable characterisation of molecular level changes on plasmids...
May 30, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28550059/europe-wide-meta-analysis-of-borrelia-burgdorferi-sensu-lato-prevalence-in-questing-ixodes-ricinus-ticks
#20
Martin Strnad, Václav Hönig, Daniel Růžek, Libor Grubhoffer, Ryan O M Rego
Lyme borreliosis is the most common zoonotic disease transmitted by ticks in Europe and North America. Despite having multiple tick vectors, the causative agent Borrelia burgdorferi sensu lato, is vectored mainly by Ixodes ricinus in Europe. In the present study, we aimed to review and summarize the existing data published from 2010 to 2016 concerning the prevalence of B. burgdorferi s.l. spirochetes in questing I. ricinus The primary focus was to evaluate the infection rate of these bacteria in ticks, accounting for tick stage, adult tick gender, region and detection method, as well as to investigate any changes in prevalence over time...
May 26, 2017: Applied and Environmental Microbiology
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