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https://www.readbyqxmd.com/read/29127407/crystal-structure-of-borrelia-turicatae-protein-bta121-a-differentially-regulated-%C3%A2-gene-in-the-tick-mammalian-transmission-cycle-of-relapsing-fever-spirochetes
#1
Zhipu Luo, Alan J Kelleher, Rabih Darwiche, Elissa M Hudspeth, Oluwatosin K Shittu, Aparna Krishnavajhala, Roger Schneiter, Job E Lopez, Oluwatoyin A Asojo
Tick-borne relapsing fever (RF) borreliosis is a neglected disease that is often misdiagnosed. RF species circulating in the United States include Borrelia turicatae, which is transmitted by argasid ticks. Environmental adaptation by RF Borrelia is poorly understood, however our previous studies indicated differential regulation of B. turicatae genes localized on the 150 kb linear megaplasmid during the tick-mammalian transmission cycle, including bta121. This gene is up-regulated by B. turicatae in the tick versus the mammal, and the encoded protein (BTA121) is predicted to be surface localized...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29063358/geographic-distribution-and-incidence-of-lyme-borreliosis-in-the-west-of-ireland
#2
A Vellinga, H Kilkelly, J Cullinan, B Hanahoe, M Cormican
BACKGROUND: Lyme borreliosis is caused by Borrelia burgdorferi and is the most common tick-transmitted infection in temperate regions. Infection often presents with erythema migrans and/or other clinical features in early infection. METHODS: Blood samples are submitted for testing for antibodies to Borrelia burgdorferi by enzyme immunoassay and positive samples are confirmed by a reference laboratory by IgG and IgM line immune assay. A retrospective extraction of all laboratory requests and results for Lyme borreliosis from 2011 to 2014 was performed...
October 23, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29052881/a-foot-tumour-as-late-cutaneous-lyme-borreliosis-a-new-entity-or-a-variant-of-an-inflammatory-proliferative-reaction-to-borrelia-burgdorferi
#3
COMMENT
H Hofmann
No abstract text is available yet for this article.
October 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29032555/in-vitro-models-of-cutaneous-inflammation
#4
Quentin Bernard, Benoît Jaulhac, Nathalie Boulanger
The skin plays an essential role in the transmission of Lyme borreliosis since it is the first interface between the Ixodes tick and the host during the inoculation of Borrelia burgdorferi sensu lato. A better understanding of the inflammatory reaction at this location is key to develop better strategies (e.g., vaccine and diagnosis) to fight this disease. In vitro cell culture of resident skin cells might constitute an approach to decipher the complex interplay between the tick, the pathogen, and the vertebrate host...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29026617/cerebral-vasculitis-and-intracranial-multiple-aneurysms-in-a-child-with-lyme-neuroborreliosis
#5
Elisa Kortela, Jukka Hytönen, Jussi Numminen, Margit Overmyer, Harri Saxen, Jarmo Oksi
Introduction. Lyme borreliosis is a multisystem tick-borne disease caused by Borrelia burgdorferi. Neurological manifestations are reported in up to 15 % of adult patients with Lyme disease, while the frequency among children is higher. The most common manifestations are painful radiculopathy, facial nerve paresis and lymphocytic meningitis. Epileptic seizures and cerebral vasculitis with stroke or aneurysms are very rare complications. Case presentation. We describe a paediatric patient with sensorineural auditory dysfunction, headache, fatigue and epileptic seizures as sequelae of meningoencephalitis/Lyme neuroborreliosis (LNB) caused by B...
April 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29020278/depressive-symptoms-in-patients-referred-to-a-tertiary-lyme-center-high-prevalence-in-those-without-evidence-of-lyme-borreliosis
#6
Tizza P Zomer, Yolande M Vermeeren, Gijs W Landman, Marlies Zwerink, Babette C van Hees, Thomas van Bemmel, Barend van Kooten
Background: Controversy exists whether mood disorders, such as depression, are associated with Lyme borreliosis (LB). The study objective was to assess prevalence of depressive symptoms in subgroups of patients referred to a tertiary Lyme center, to investigate whether depressive symptoms can be used in clinical practice to discriminate for LB. Methods: This cohort study included adult patients who visited a tertiary Lyme center between January 2008 and December 2014...
July 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28987040/-history-of-the-study-epidemiology-of-the-disease-and-characterization-of-borrelia-burgdorferi-infection
#7
EDITORIAL
Tadeusz Płusa
From the beginning of the twentieth century interest in tick-borne borreliosis continues to be an important diagnostic and therapeutic problem. In 1977, in Lyme and Old Lyme, Cunnecticut, in the United States, arthritis and skin lesions were described in 12 children, which were associated with tick bites. The name of the place was called a syndrome of Lyme disease. Dr Willy Burgdorfer observed microaerophilic Gram-negative bacteria (Spirochetes) with a diameter of 0.3-0.5 µm and a length of about 20-30 µm, which were isolated from the tick colon...
September 29, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28953957/ige-reactivity-to-%C3%AE-gal-in-relation-to-lyme-borreliosis
#8
Ivar Tjernberg, Carl Hamsten, Danijela Apostolovic, Marianne van Hage
BACKGROUND: An association between tick bites, the development of immunoglobulin E (IgE) antibodies to galactose-α-1, 3-galactose (α-Gal) and red meat allergy has recently been reported. Here we wanted to elucidate the relation between tick exposure, IgE antibodies to α-Gal and Lyme borreliosis (LB). METHODS: In the highly LB endemic area of Kalmar County, Sweden, serum samples and health inquiries from 518 blood donors were included. All sera were investigated for multiple IgG anti-Borrelia antibodies using a multiplex assay (recomBead, Mikrogen)...
2017: PloS One
https://www.readbyqxmd.com/read/28953009/borrelia-lymphocytoma-mimicking-butterfly-rash-in-a-pediatric-patient
#9
Mar Llamas-Velasco, Bruno Emilio Paredes
A 5-year-old girl presented with a facial butterfly rash that persisted for 5 months without arthralgia, fever, malaise, photosensitivity, or other symptoms. Lupus erythematosus was clinically suspected. All blood tests were negative or within normal values. Skin biopsy showed a dense nodular superficial and deep inflammatory infiltrate of lymphocytes that reaches subcutaneous tissue. The most striking histopathological finding was plasma cells with some perifollicular accentuation. Borrelia polymerase chain reaction assay of the tissue was positive, and we made the diagnoses of borrelia lymphocytoma mimicking butterfly rash of lupus erythematosus...
September 20, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28948805/neuroborreliosis-in-patients-hospitalised-for-lyme-borreliosis-in-the-czech-republic-in-2003-2013
#10
B Kříž, M Malý, M Daniel
STUDY OBJECTIVE: The objective was to analyse and evaluate a cohort of Lyme borreliosis (LB) patients with neuroborreliosis (LNB) hospitalised in the Czech Republic in 2003-2013. MATERIAL AND METHODS: Data analysed in this study were obtained from the National Register of Hospitalised Patients, which is a nationwide population register maintained at the Institute of Health Information and Statistics of the Czech Republic. Data collection from all departments of bed care establishments are regularly processed every year...
2017: Epidemiologie, Mikrobiologie, Imunologie
https://www.readbyqxmd.com/read/28943834/cutaneous-lyme-borreliosis-guideline-of-the-german-dermatology-society
#11
Heidelore Hofmann, Volker Fingerle, Klaus-Peter Hunfeld, Hans-Iko Huppertz, Andreas Krause, Sebastian Rauer, Bernhard Ruf
This guideline of the German Dermatology Society primarily focuses on the diagnosis and treatment of cutaneous manifestations of Lyme borreliosis. It has received consensus from 22 German medical societies and 2 German patient organisations. It is the first part of an AWMF (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V.) interdisciplinary guideline: "Lyme Borreliosis - Diagnosis and Treatment, development stage S3". The guideline is directed at physicians in private practices and clinics who treat Lyme borreliosis...
2017: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/28939383/prevalence-of-borrelia-burgdorferi-and-borrelia-miyamotoi-in-questing-ixodes-ricinus-ticks-from-four-sites-in-the-uk
#12
Scott J Layzell, Daniel Bailey, Mick Peacey, Patricia A Nuttall
Borrelia miyamotoi is a spirochete bacterium related to Borrelia burgdorferi sensu lato, the cause of Lyme borreliosis, and vectored by ticks. In 2014, B. miyamotoi was identified in three questing Ixodes ricinus collected in the UK. We sought to confirm the presence of B. miyamotoi in the UK. Ticks were collected from four locations not previously investigated for B. miyamotoi or B. burgdorferi s.l. and of which two are considered as Lyme borreliosis "hotspots" based on hospital records of the disease. We independently confirm that B...
September 18, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28937997/molecular-detection-of-borrelia-burgdorferi-sensu-lato-an-analytical-comparison-of-real-time-pcr-protocols-from-five-different-scandinavian-laboratories
#13
MULTICENTER STUDY
Malin Lager, Maximilian Faller, Peter Wilhelmsson, Vivian Kjelland, Åshild Andreassen, Rimtas Dargis, Hanne Quarsten, Ram Dessau, Volker Fingerle, Gabriele Margos, Sølvi Noraas, Katharina Ornstein, Ann-Cathrine Petersson, Andreas Matussek, Per-Eric Lindgren, Anna J Henningsson
INTRODUCTION: Lyme borreliosis (LB) is the most common tick transmitted disease in Europe. The diagnosis of LB today is based on the patient´s medical history, clinical presentation and laboratory findings. The laboratory diagnostics are mainly based on antibody detection, but in certain conditions molecular detection by polymerase chain reaction (PCR) may serve as a complement. AIM: The purpose of this study was to evaluate the analytical sensitivity, analytical specificity and concordance of eight different real-time PCR methods at five laboratories in Sweden, Norway and Denmark...
2017: PloS One
https://www.readbyqxmd.com/read/28927817/development-and-evaluation-of-a-two-step-multiplex-taqman-real-time-pcr-assay-for-detection-quantification-of-different-genospecies-of-borrelia-burgdorferi-sensu-lato
#14
Mónica Nunes, Ricardo Parreira, Teresa Carreira, João Inácio, Maria Luísa Vieira
Nowadays, at least four clinically important B. burgdorferi sensu lato (s.l.) genospecies (B. afzelii, B. garinii, B. burgdorferi sensu stricto (s.s.) and B. lusitaniae) circulate in Portugal. Each genospecies has a different tropism that resuls in a diverse array of clinical manifestations. The standard diagnostic procedure used is normally simple, nevertheless, during the "window-period" phase, in which specific antibodies cannot yet be detected, diagnosis becomes difficult, and calls for reliable, sensitive and specific laboratory methods, such as molecular tests...
September 11, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28887186/to-test-or-not-to-test-laboratory-support-for-the-diagnosis-of-lyme-borreliosis
#15
REVIEW
Ram B Dessau, Alje P van Dam, Volker Fingerle, Jeremy Gray, Joppe Hovius, Klaus-Peter Hunfeld, Benoit Jaulhac, Olaf Kahl, Wolfgang Kristoferitsch, Per-Eric Lindgren, Mateusz Markowicz, Sally Mavin, Katharina Ornstein, Tobias Rupprecht, Gerold Stanek, Franc Strle
BACKGROUND: Lyme borreliosis (LB) is a tick-borne infection caused by Borrelia burgdorferi sensu lato. The most frequent clinical manifestations are erythema migrans and Lyme neuroborreliosis. Currently, a large volume of diagnostic testing for Lyme borreliosis is reported, whereas the incidence of clinically relevant disease manifestations is low. This indicates overuse of diagnostic testing for LB with implications for patient care and cost effective health management. AIM: The recommendations provided in this review are intended to support both the clinical diagnosis and initiatives for a more rational use of laboratory testing in patients with clinically suspected Lyme borreliosis...
September 5, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28874197/environmental-drivers-of-ixodes-ricinus-abundance-in-forest-fragments-of-rural-european-landscapes
#16
Steffen Ehrmann, Jaan Liira, Stefanie Gärtner, Karin Hansen, Jörg Brunet, Sara A O Cousins, Marc Deconchat, Guillaume Decocq, Pieter De Frenne, Pallieter De Smedt, Martin Diekmann, Emilie Gallet-Moron, Annette Kolb, Jonathan Lenoir, Jessica Lindgren, Tobias Naaf, Taavi Paal, Alicia Valdés, Kris Verheyen, Monika Wulf, Michael Scherer-Lorenzen
BACKGROUND: The castor bean tick (Ixodes ricinus) transmits infectious diseases such as Lyme borreliosis, which constitutes an important ecosystem disservice. Despite many local studies, a comprehensive understanding of the key drivers of tick abundance at the continental scale is still lacking. We analyze a large set of environmental factors as potential drivers of I. ricinus abundance. Our multi-scale study was carried out in deciduous forest fragments dispersed within two contrasting rural landscapes of eight regions, along a macroclimatic gradient stretching from southern France to central Sweden and Estonia...
September 6, 2017: BMC Ecology
https://www.readbyqxmd.com/read/28869190/year-to-year-variation-in-the-density-of-ixodes-ricinus-ticks-and-the-prevalence-of-the-rodent-associated-human-pathogens-borrelia-afzelii-and-b-miyamotoi-in-different-forest-types
#17
Sanne C Ruyts, Wesley Tack, Evy Ampoorter, Elena C Coipan, Erik Matthysen, Dieter Heylen, Hein Sprong, Kris Verheyen
The human pathogens Borrelia afzelii, which causes Lyme borreliosis and B. miyamotoi, which causes relapsing fever, both circulate between Ixodes ricinus ticks and rodents. The spatiotemporal dynamics in the prevalence of these pathogens have not yet been fully elucidated, but probably depend on the spatiotemporal population dynamics of small rodents. We aimed to evaluate the effect of different forest types on the density of infected nymphs in different years and to obtain more knowledge about the spatial and temporal patterns of ticks and tick-borne pathogens...
August 26, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28863166/the-novel-lyme-borreliosis-vaccine-vla15-shows-broad-protection-against-borrelia-species-expressing-six-different-ospa-serotypes
#18
Pär Comstedt, Wolfgang Schüler, Andreas Meinke, Urban Lundberg
We have previously shown that the Outer surface protein A (OspA) based Lyme borreliosis vaccine VLA15 induces protective immunity in mice. Herein, we report the induction of protective immunity by VLA15 with mouse models using ticks infected with B. burgdorferi (OspA serotype 1), B. afzelii (OspA serotype 2) and B. bavariensis (OspA serotype 4) or with in vitro grown B. garinii (OspA serotype 5 and 6) for challenge. For B. garinii (OspA serotype 3), we have developed a growth inhibition assay using chicken complement and functional antibodies targeting B...
2017: PloS One
https://www.readbyqxmd.com/read/28854805/two-mice-models-for-transferability-of-zoonotic-bacteria-via-tick-vector
#19
B Sallay, T Vaculová, M Derdáková, V Rusňáková Tarageľová, E Špitalská, Ľ Škultéty
Spotted fever and typhus-related diseases caused by rickettsiae, Lyme borreliosis induced by spirochetes from Borrelia burgdorferii sensu lato complex, and Q fever evoked by Coxiella burnetii, are important zoonoses occurring worldwide. In order to study the pathogenesis of these infections, the efficacy of vaccines from the perspective of protection against the pathogens, pathogen - pathogen interactions during co-infections or pathogen-vector-host interrelationship, a suitable animal model should be established...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28846709/infection-of-ixodes-ricinus-by-borrelia-burgdorferi-sensu-lato-in-peri-urban-forests-of-france
#20
Axelle Marchant, Alain Le Coupanec, Claire Joly, Emeline Perthame, Natacha Sertour, Martine Garnier, Vincent Godard, Elisabeth Ferquel, Valerie Choumet
Lyme borreliosis is the most common tick-borne disease in the northern hemisphere. In Europe, it is transmitted by Ixodes ticks that carry bacteria belonging to the Borrelia burgdorferi sensu lato complex. The objective of this work was to explore eco-epidemiological factors of Lyme borreliosis in peri-urban forests of France (Sénart, Notre-Dame and Rambouillet). We investigated whether the introduction of Tamias sibiricus in Sénart could alter the density of infected ticks. Moreover, the density and tick infection were investigated according to the tree species found in various patches of Sénart forest...
2017: PloS One
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