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https://www.readbyqxmd.com/read/29776377/shifts-in-borrelia-burgdorferi-s-l-geno-species-infections-in-ixodes-ricinus-over-a-10-year-surveillance-period-in-the-city-of-hanover-germany-and-borrelia-miyamotoi-specific-reverse-line-blot-detection
#1
Katrin Blazejak, Marie-Kristin Raulf, Elisabeth Janecek, Daniela Jordan, Volker Fingerle, Christina Strube
BACKGROUND: Lyme borreliosis caused by spirochetes of the Borrelia burgdorferi (sensu lato) complex is still the most common tick-borne disease in Europe, posing a considerable threat to public health. The predominant vector in Europe is the widespread hard tick Ixodes ricinus, which also transmits the relapsing fever spirochete B. miyamotoi as well as pathogenic Rickettsiales (Anaplasma phagocytophilum, Rickettsia spp.). To assess the public health risk, a long-term monitoring of tick infection rates with the named pathogens is indispensable...
May 18, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29753651/integrated-metatranscriptomics-and-metaproteomics-for-the-characterization-of-bacterial-microbiota-in-unfed-ixodes-ricinus
#2
Angélica Hernández-Jarguín, Sandra Díaz-Sánchez, Margarita Villar, José de la Fuente
An innovative metaomics approach integrating metatranscriptomics and metaproteomics was used to characterize bacterial communities in the microbiota of the Lyme borreliosis spirochete vector, Ixodes ricinus (Acari: Ixodidae). Whole internal tissues and salivary glands from unfed larvae and female ticks, respectively were used. Reused I. ricinus RNA-sequencing data for metranscriptomics analysis together with metaproteomics provided a better characterization of tick bacterial microbiota by increasing bacteria identification and support for identified bacteria with putative functional implications...
May 5, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29746581/human-neuroglial-cells-internalize-borrelia-burgdorferi-by-coiling-phagocytosis-mediated-by-daam1
#3
Shanna K Williams, Zachary P Weiner, Robert D Gilmore
Borrelia burgdorferi, the agent of Lyme borreliosis, can elude hosts' innate and adaptive immunity as part of the course of infection. The ability of B. burgdorferi to invade or be internalized by host cells in vitro has been proposed as a mechanism for the pathogen to evade immune responses or antimicrobials. We have previously shown that B. burgdorferi can be internalized by human neuroglial cells. In this study we demonstrate that these cells take up B. burgdorferi via coiling phagocytosis mediated by the formin, Daam1, a process similarly described for human macrophages...
2018: PloS One
https://www.readbyqxmd.com/read/29739424/influence-of-climatic-factors-on-ixodes-ricinus-nymph-abundance-and-phenology-over-a-long-term-monthly-observation-in-switzerland-2000-2014
#4
Gaël Hauser, Olivier Rais, Francisca Morán Cadenas, Yves Gonseth, Mahmoud Bouzelboudjen, Lise Gern
BACKGROUND: One of the major public health challenges in the field of communicable diseases consists of being able to predict where and when a population is at risk of being infected by a pathogen. In the case of vector-borne diseases, such predictions often require strong ecological knowledge of the vector life-cycle and the environmental conditions promoting or preventing its establishment and maintenance. In this study, we analyse how climatic factors influence the abundance and phenology of the Lyme borreliosis vector Ixodes ricinus in a Swiss temperate forest, based on a long-term monthly observation over a period of 15 years (2000 and 2014)...
May 8, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29723263/borrelia-burgdorferi-adhere-to-blood-vessels-in-the-dura-mater-and-are-associated-with-increased-meningeal-t-cells-during-murine-disseminated-borreliosis
#5
Ali Divan, Timothy Casselli, S Anand Narayanan, Sanjib Mukherjee, David C Zawieja, John A Watt, Catherine A Brissette, M Karen Newell-Rogers
Borrelia burgdorferi, the causative agent of Lyme disease, is a vector-borne bacterial infection that is transmitted through the bite of an infected tick. If not treated with antibiotics during the early stages of infection, disseminated infection can spread to the central nervous system (CNS). In non-human primates (NHPs) it has been demonstrated that the leptomeninges are among the tissues colonized by B. burgdorferi spirochetes. Although the NHP model parallels aspects of human borreliosis, a small rodent model would be ideal to study the trafficking of spirochetes and immune cells into the CNS...
2018: PloS One
https://www.readbyqxmd.com/read/29716838/low-probability-of-a-dilution-effect-for-lyme-borreliosis-in-belgian-forests
#6
Sanne C Ruyts, Dries Landuyt, Evy Ampoorter, Dieter Heylen, Steffen Ehrmann, Elena C Coipan, Erik Matthysen, Hein Sprong, Kris Verheyen
An increasing number of studies have investigated the consequences of biodiversity loss for the occurrence of vector-borne diseases such as Lyme borreliosis, the most common tick-borne disease in the northern hemisphere. As host species differ in their ability to transmit the Lyme borreliosis bacteria Borrelia burgdorferi s.l. to ticks, increased host diversity can decrease disease prevalence by increasing the proportion of dilution hosts, host species that transmit pathogens less efficiently. Previous research shows that Lyme borreliosis risk differs between forest types and suggests that a higher diversity of host species might dilute the contribution of small rodents to infect ticks with B...
April 22, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29665403/lack-of-serological-evidence-for-lyme-like-borreliosis-in-brazil
#7
Stefan Vilges de Oliveira, Álvaro A Faccini-Martínez, Crispim Cerutti
No abstract text is available yet for this article.
April 14, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29664394/dynamics-of-spirochetemia-and-early-pcr-detection-of-borrelia-miyamotoi
#8
Lyudmila Karan, Marat Makenov, Nadezhda Kolyasnikova, Olga Stukolova, Marina Toporkova, Olga Olenkova
We investigated whether Borrelia miyamotoi disease can be detected in its early stage by using PCR for borrelial 16S rRNA, which molecule (DNA or RNA) is the best choice for this test, and whether spirochetes are present in blood during the acute phase of B. miyamotoi disease. A total of 473 patients with a suspected tickborne infection in Yekaterinburg, Russia, in 2009, 2010, and 2015 were enrolled in this study. Blood samples were analyzed by using quantitative PCR or ELISA, and a diagnosis of borreliosis was confirmed for 310 patients...
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29661882/-in-vitro-antimicrobial-susceptibility-of-clinical-isolates-of-borrelia-miyamotoi
#9
Joris Koetsveld, Annemijn Manger, Dieuwertje Hoornstra, Ronald O Draga, Anneke Oei, Nadezhda M Kolyasnikova, Marina G Toporkova, Denis S Sarksyan, Alex Wagemakers, Alexander E Platonov, Joppe W Hovius
Objectives : Borrelia miyamotoi is an emerging relapsing fever (RF) Borrelia species that is described to cause human disease in regions where Lyme borreliosis is endemic. We have recently shown that B. miyamotoi tick isolates are resistant to amoxicillin in vitro, however, clinical isolates have not been studied. Therefore, our aim was to show antimicrobial susceptibility of recently obtained clinical isolates of B. miyamotoi Methods : A dilution series of various antibiotics was made in MKP-F media. Susceptibility of different clinical B...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29660558/multilocus-sequence-analysis-of-borrelia-burgdorferi-sensu-lato-isolates-from-western-siberia-russia-and-northern-mongolia
#10
Yuliya Sabitova, Nataliya Fomenko, Artem Tikunov, Oleg Stronin, Maxim Khasnatinov, Davaajav Abmed, Galina Danchinova, Irina Golovljova, Nina Tikunova
Lyme borreliosis (LB) is the most frequently recorded tick-transmitted disease in Eurasia. Tomsk Province, Western Siberia in Russia and Selenge Aimag in Northern Mongolia are leading regions in the LB incidence rate in these countries. Spirochaetes of the Borrelia burgdorferi sensu lato (s.l.) complex isolated from Ixodes ticks from Tomsk Province (n = 56) and Ixodes persulcatus ticks from Selenge Aimag (n = 5) were genetically characterized using Multi Locus Sequence Typing (MLST), analysis of the 5S23S rRNA intergenic spacer (IGS) amplicons, and p83/100 gene sequencing...
April 13, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29614977/diagnostic-behaviour-of-general-practitioners-when-suspecting-lyme-disease-a-database-study-from-2010-2015
#11
Esmée Botman, C Wim Ang, Johanna H K Joosten, Pauline Slottje, Johannes C van der Wouden, Otto R Maarsingh
BACKGROUND: Due to the raised public awareness of Lyme Borreliosis (LB), its increased incidence and the increased availability of serological tests, the demand for diagnostic testing on LB has increased. This may affect the diagnostic behaviour of general practitioners (GPs). Aim of our study was to describe GPs' diagnostic behaviour when suspecting LB. METHODS: In this descriptive study from January 2010 to June 2015, we used the anonymized electronic medical records of 56,996 patients registered in 12 general practices in Amsterdam, The Netherlands...
April 3, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29610317/plasticity-in-early-immune-evasion-strategies-of-a-bacterial-pathogen
#12
Quentin Bernard, Alexis A Smith, Xiuli Yang, Juraj Koci, Shelby D Foor, Sarah D Cramer, Xuran Zhuang, Jennifer E Dwyer, Yi-Pin Lin, Emmanuel F Mongodin, Adriana Marques, John M Leong, Juan Anguita, Utpal Pal
Borrelia burgdorferi is one of the few extracellular pathogens capable of establishing persistent infection in mammals. The mechanisms that sustain long-term survival of this bacterium are largely unknown. Here we report a unique innate immune evasion strategy of B. burgdorferi , orchestrated by a surface protein annotated as BBA57, through its modulation of multiple spirochete virulent determinants. BBA57 function is critical for early infection but largely redundant for later stages of spirochetal persistence, either in mammals or in ticks...
April 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29608590/cost-effectiveness-of-longer-term-versus-shorter-term-provision-of-antibiotics-in-patients-with-persistent-symptoms-attributed-to-lyme-disease
#13
Anneleen Berende, Lisette Nieuwenhuis, Hadewych J M Ter Hofstede, Fidel J Vos, Michiel L Vogelaar, Mirjam Tromp, Henriët van Middendorp, A Rogier T Donders, Andrea W M Evers, Bart Jan Kullberg, Eddy M M Adang
BACKGROUND: The treatment of persistent symptoms attributed to Lyme disease remains controversial. Recently, the PLEASE study did not demonstrate any additional clinical benefit of longer-term versus shorter-term antibiotic treatment. However, the economic impact of the antibiotic strategies has not been investigated. METHODS: This prospective economic evaluation, adhering a societal perspective, was performed alongside the PLEASE study, a multicenter, placebo-controlled, double-blind 1:1:1 randomized clinical trial in which all patients received open-label intravenous ceftriaxone for two weeks before the 12-week randomized blinded oral antibiotic regimen (doxycycline, clarithromycin plus hydroxychloroquine, or placebo)...
2018: PloS One
https://www.readbyqxmd.com/read/29606622/factors-responsible-for-ixodes-ricinus-nymph-abundance-are-soil-features-indicators-of-tick-abundance-in-a-french-region-where-lyme-borreliosis-is-endemic
#14
Valérie Goldstein, Nathalie Boulanger, Dominique Schwartz, Jean-Claude George, Damien Ertlen, Laurence Zilliox, Mickaël Schaeffer, Benoît Jaulhac
In Europe, the hard tick Ixodes ricinus (Acari: Ixodidae) is the main vector of Lyme borreliosis spirochetes (Borrelia burgdorferi sensu lato group). A field study was conducted to evaluate the abundance of Ixodes nymphs in the French region of Alsace, where Lyme borreliosis is endemic, and to determine whether environmental factors such as soil moisture and composition may be associated with nymph abundance. In the ten sites studied, ticks were collected by drag sampling from March to October in 2013 and 2014...
March 26, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29606016/laboratory-diagnosis-of-lyme-borreliosis-current-state-of-the-art-and-future-perspectives
#15
Benedikt Lohr, Volker Fingerle, Douglas E Norris, Klaus-Peter Hunfeld
This review is directed at physicians and laboratory personnel in private practice and clinics who treat and diagnose Lyme borreliosis (LB) in patients as part of their daily work. A major objective of this paper is to bring together background information on Borrelia (B.) burgdorferi sensu lato (s.l.) and basic clinical knowledge of LB, which is one of the most frequently reported vector-borne diseases in the Northern Hemisphere. The goal is to provide practical guidance for clinicians and for laboratory physicians, and scientists for a better understanding of current achievements and ongoing obstacles in the laboratory diagnosis of LB, an infectious disease that still remains one of the diagnostic chameleons of modern clinical medicine...
April 2, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29600690/occurrence-of-lyme-disease-infection-in-a-non-endemic-area-in-northern-italy
#16
Sara G Rimoldi, Stefania Merli, Giovanna Bestetti, Vania Giacomet, Giuliana Cislaghi, Romualdo Grande, Sergio Sanzani, Cristina Pagani, Giusto Trevisan, Eleonora DE Faveri, Maria R Gismondo, Eva Ruzić-Sabljić
BACKGROUND: In Italy, the incidence of human tick borne disease has increased over the last decades. Since 2015 a multidisciplinary group has been established in Sacco Hospital for the management of the patients affected by Lyme Disease (LD). A retrospective evaluation (2015-2017) was performed for LD in non-endemic areas. METHODS: Retrospective analysis of all 1000 samples for 800 patients screened for LD antibodies at the Sacco Hospital in 3 years (2015-2017)...
March 29, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29566442/acvim-consensus-update-on-lyme-borreliosis-in-dogs-and-cats
#17
Meryl P Littman, Bernhard Gerber, Richard E Goldstein, Mary Anna Labato, Michael R Lappin, George E Moore
An update of the 2006 American College of Veterinary Internal Medicine (ACVIM) Small Animal Consensus Statement on Lyme Disease in Dogs: Diagnosis, Treatment, and Prevention was presented at the 2016 ACVIM Forum in Denver, CO, followed by panel and audience discussion and a drafted consensus statement distributed online to diplomates for comment. The updated consensus statement is presented below. The consensus statement aims to provide guidance on the diagnosis, treatment, and prevention of Lyme borreliosis in dogs and cats...
March 22, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29563715/a-novel-scoring-system-approach-to-assess-patients-with-lyme-disease-nutech-functional-score
#18
Geeta Shroff, Petra Hopf-Seidel
Introduction: A bacterial infection by Borrelia burgdorferi referred to as Lyme disease (LD) or borreliosis is transmitted mostly by a bite of the tick Ixodes scapularis in the USA and Ixodes ricinus in Europe. Various tests are used for the diagnosis of LD, but their results are often unreliable. We compiled a list of clinically visible and patient-reported symptoms that are associated with LD. Based on this list, we developed a novel scoring system. Methodology: Nutech functional Score (NFS), which is a 43 point positional (every symptom is subgraded and each alternative gets some points according to its position) and directional (moves in direction bad to good) scoring system that assesses the patient's condition...
January 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29560357/crimean-congo-hemorrhagic-fever-virus-and-borrelia-burgdorferi-sensu-lato-in-ticks-from-kosovo-and-albania
#19
Kurtesh Sherifi, Agim Rexhepi, Kristaq Berxholi, Blerta Mehmedi, Rreze M Gecaj, Zamira Hoxha, Anja Joachim, Georg G Duscher
Tick-borne diseases pose a serious threat to human health in South-Eastern Europe, including Kosovo. While Crimean-Congo hemorrhagic fever (CCHF) is a well-known emerging infection in this area, there are no accurate data on Lyme borreliosis and tick-borne encephalitis (TBE). Therefore, we sampled and tested 795 ticks. Ixodes ricinus ( n  = 218), Dermacentor marginatus ( n  = 98), and Haemaphysalis spp. ( n  = 24) were collected from the environment by flagging (all from Kosovo), while Hyalomma marginatum ( n  = 199 from Kosovo, all from Kosovo) and Rhipicephalus bursa ( n  = 130, 126 from Albania) could be collected only by removal from animal pasture and domestic ruminants...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29559369/assessment-of-hmgb-1-concentration-in-tick-borne-encephalitis-and-neuroborreliosis
#20
Anna Moniuszko-Malinowska, Paweł Penza, Piotr Czupryna, Olga Zajkowska, Sławomir Pancewicz, Renata Świerzbińska, Justyna Dunaj, Joanna Zajkowska
BACKGROUND: The aim of this study was to determine the concentration of HMGB-1 (high mobility group box 1) in the serum and cerebrospinal fluid (CSF) of patients suffering from tick-borne encephalitis (TBE) and neuroborreliosis (NB). Focus was placed on HMGB-1 measurement in the CSF or serum in order to establish whether this could help to differentiate between NB and TBE. METHODS: Eighty patients with meningitis and meningoencephalitis were enrolled in the study...
March 17, 2018: International Journal of Infectious Diseases: IJID
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