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https://www.readbyqxmd.com/read/27922168/update-of-the-swiss-guidelines-on-post-treatment-lyme-disease-syndrome
#1
Johannes Nemeth, Enos Bernasconi, Ulrich Heininger, Mohamed Abbas, David Nadal, Carol Strahm, Stefan Erb, Stefan Zimmerli, Hansjakob Furrer, Julie Delaloye, Thierry Kuntzer, Ekkehard Altpeter, Mathias Sturzenegger, Rainer Weber, For The Swiss Society For Infectious Diseases And The Swiss Society For Neurology
Lyme borreliosis is caused by Borrelia burgdorferi sensu lato infection, which responds well to antibiotic therapy in the overwhelming majority of cases. However, despite adequate antibiotic treatment some patients report persisting symptoms which are commonly summarised as post-treatment Lyme disease syndrome (PTLDS). In 2005, the Swiss Society of Infectious Diseases published a case definition for PTLDS. We aimed to review the scientific literature with a special emphasis on the last 10 years, questioning whether the definitions from 2005 are still valid in the light of current knowledge...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27920571/commercial-test-kits-for-detection-of-lyme-borreliosis-a-meta-analysis-of-test-accuracy
#2
Michael J Cook, Basant K Puri
The clinical diagnosis of Lyme borreliosis can be supported by various test methodologies; test kits are available from many manufacturers. Literature searches were carried out to identify studies that reported characteristics of the test kits. Of 50 searched studies, 18 were included where the tests were commercially available and samples were proven to be positive using serology testing, evidence of an erythema migrans rash, and/or culture. Additional requirements were a test specificity of ≥85% and publication in the last 20 years...
2016: International Journal of General Medicine
https://www.readbyqxmd.com/read/27916969/immunogenetic-markers-definition-in-latvian-patients-with-lyme-borreliosis-and-lyme-neuroborreliosis
#3
Lilija Kovalchuka, Svetlana Cvetkova, Julija Trofimova, Jelena Eglite, Sandra Gintere, Irina Lucenko, Barbara Oczko-Grzesik, Ludmila Viksna, Angelika Krumina
The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction- sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles...
December 1, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27900646/the-potential-of-omics-technologies-in-lyme-disease-biomarker-discovery-and-early-detection
#4
REVIEW
Alaa Badawi
Lyme borreliosis (LB) is the most prevalent arthropod-borne infectious disease in North America and many countries of the temperate Northern Hemisphere. It is associated with local and systemic manifestations and has persistent post-treatment health complications in some individuals. Innate and acquired immunity-related inflammation is likely to play a critical role in both host defense against Borrelia burgdorferi and disease severity. Large-scale analytical approaches to quantify gene expression (transcriptomics), proteins (proteomics) and metabolites (metabolomics) in LB have recently emerged with a potential to advance the development of disease biomarkers in early, disseminated and posttreatment disease stages...
November 29, 2016: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/27892737/progress-in-the-molecular-diagnosis-of-lyme-disease
#5
Eva Ružić-Sabljić, Tjaša Cerar
Current laboratory testing of Lyme borreliosis mostly relies on serological methods with known limitations. Diagnostic modalities enabling direct detection of pathogen at the onset of the clinical signs could overcome some of the limitations. Molecular methods detecting borrelial DNA seem to be the ideal solution, although there are some aspects that need to be considered. Areas covered: This review represent summary and discussion of the published data obtained from literature searches from PubMed and The National Library of Medicine (USA) together with our own experience on molecular diagnosis of Lyme disease...
November 28, 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27883377/borrelia-burgdorferi-%C3%A2-morphological-structure-and-motility-as-adaptation-for-transmission-and-survival-in-the-habitat-of-a-tick-vertebrate-setup
#6
Paweł Penza, Anna Moniuszko-Malinowska, Piotr Czupryna, Sławomir Pancewicz, Joanna Zajkowska
Lyme borreliosis is a multisystem chronic disease caused by Borrelia burgdorferi sensu lato (s.l.) spirochete transmitted by Ixodes. This bacterium has a remarkable ability to survive in tick-vertebrate setup. Its infection causes diagnostic and clinical difficulties. It was distinguished as a separate disease entity over 30 years ago. Observations made by Steere et al. proved to be a milestone since they found correlation between the occurrence of skin and joint lesions with tick bites. Further studies showed that the disease affects not only joints and skin, but also nervous and circulatory systems...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27876087/heterogeneity-in-the-abundance-and-distribution-of-ixodes-ricinus-and-borrelia-burgdorferi-sensu-lato-in-scotland-implications-for-risk-prediction
#7
Caroline Millins, Lucy Gilbert, Paul Johnson, Marianne James, Elizabeth Kilbride, Richard Birtles, Roman Biek
BACKGROUND: Cases of Lyme borreliosis, a vector-borne zoonosis caused by bacteria in the Borrelia burgdorferi (sensu lato) species group, have increased in recent years in Europe. Knowledge of environmental factors associated with abundance of the tick vector Ixodes ricinus and the pathogen B. burgdorferi (s.l.) is of interest to understand responses to environmental changes, predict variation in risk and to inform management interventions. METHODS: Nineteen woodland sites across Scotland were surveyed in 2012 for B...
November 22, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27866446/clinical-and-serological-one-year-follow-up-of-patients-after-the-bite-of-ixodes-ricinus-ticks-infected-with-borrelia-burgdorferi-sensu-lato
#8
Violeta T Briciu, Mirela Flonta, Doina F Ţăţulescu, Fabian Meyer, Daniela Sebah, Dumitru Cârstina, Andrei D Mihalca, Călin M Gherman, Cecilia Hizo-Teufel, Ingrid Huber, Volker Fingerle, Mihaela Lupșe
BACKGROUND: The risk of developing Lyme borreliosis (LB) after the bite of a Borrelia (B.) burgdorferi sensu lato (s.l.) infected tick in Romania is unknown. METHODS: The present prospective study, performed in 2010-2011 in a hospital in Romania, has followed-up clinical and serological outcome of patients that presented with B. burgdorferi positive Ixodes (I.) ricinus bite. A second group of patients, including age, sex and residence-matched individuals bitten by B...
November 21, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27857714/t-cells-exacerbate-lyme-borreliosis-in-tlr2-deficient-mice
#9
Carrie E Lasky, Carmela L Pratt, Kinsey A Hilliard, John L Jones, Charles R Brown
Infection of humans with the spirochete, Borrelia burgdorferi, causes Lyme borreliosis and can lead to clinical manifestations such as arthritis, carditis, and neurological conditions. Experimental infection of mice recapitulates many of these symptoms and serves as a model system for the investigation of disease pathogenesis and immunity. Innate immunity is known to drive the development of Lyme arthritis and carditis, but the mechanisms driving this response remain unclear. Innate immune cells recognize B...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27852247/education-on-tick-bite-and-lyme-borreliosis-prevention-aimed-at-schoolchildren-in-the-netherlands-comparing-the-effects-of-an-online-educational-video-game-versus-a-leaflet-or-no-intervention
#10
D J M A Beaujean, F Gassner, A Wong, J E Steenbergen, R Crutzen, D Ruwaard
BACKGROUND: Lyme disease or Lyme borreliosis (LB) is the most common tick-borne disease both in the United States and Europe. Children, in particular, are at high risk of contracting LB. Since child-specific educational tools on ticks, tick bites and LB are lacking, we developed an online educational video game. In this study, we compared the effectiveness of an online educational video game versus a newly developed leaflet aimed to improve prevention of tick bites and LB among Dutch schoolchildren...
November 16, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27847963/-challenge-of-neuroborreliosis
#11
A Spreer, S Rauer, H Wilking, V Fingerle
Lyme borreliosis is the most frequent tick-borne infection in Europe. It is a multisystemic disease affecting the skin, joints, heart, in rare cases the eyes and regularly the nervous system. Taking current clinical and microbiological guidelines into account, neuroborreliosis can in general be diagnosed and treated successfully. An appropriate guideline-conform antibiotic treatment is effective and in most cases recovery from acute neuroborreliosis is complete. Nevertheless, the evidence base regarding pharmacological treatment needs reform and improvement...
December 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27836839/multi-strain-infections-of-the-lyme-borreliosis-pathogen-in-the-tick-vector
#12
Jonas Durand, Coralie Herrmann, Dolores Genné, Anouk Sarr, Lise Gern, Maarten J Voordouw
: Mixed or multiple-strain infections are common in vector-borne diseases and have important implications for the epidemiology of these pathogens. Previous studies have mainly focused on interactions between pathogen strains in the vertebrate host, but little is known about what happens in the arthropod vector. Borrelia afzelii and B. garinii are two species of spirochete bacteria that cause Lyme borreliosis in Europe and that share a common tick vector Ixodes ricinus Each of these two tick-borne pathogens consists of multiple strains that are often differentiated using the highly polymorphic ospC gene...
November 11, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27830900/re-no-prolonged-antibiotic-therapy-for-disease-attributed-to-borreliosis
#13
Per H Bjark
No abstract text is available yet for this article.
November 2016: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/27796648/prevalence-of-serological-response-to-borrelia-burgdorferi-in-farmers-from-eastern-and-central-poland
#14
V Zając, J Pinkas, A Wójcik-Fatla, J Dutkiewicz, A Owoc, I Bojar
Lyme borreliosis (Lyme disease) caused by the Borrelia burgdorferi sensu lato spirochete is the most common tick-borne infection manifested by a wide spectrum of clinical symptoms. In Poland, the preventive health care does not comprise individual farmers as it is practiced in foresters. The objective of this study was to evaluate the exposure of Polish farmers to infection with B. burgdorferi, based on serological screening test and epidemiological investigation. A total of 3,597 farmers were examined for the presence of B...
October 31, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27769883/brazilian-borreliosis-with-special-emphasis-on-humans-and-horses
#15
Roberta Carvalho Basile, Natalino Hajime Yoshinari, Elenice Mantovani, Virgínia Nazário Bonoldi, Delphim da Graça Macoris, Antonio de Queiroz-Neto
Borreliosis caused by Borrelia burgdorferi sensu lato is a cosmopolitan zoonosis studied worldwide; it is called Lyme disease in many countries of the Northern Hemisphere and Lyme-like or Baggio-Yoshinari Syndrome in Brazil. However, despite the increasing number of suspect cases, this disease is still neglected in Brazil by the medical and veterinary communities. Brazilian Lyme-like borreliosis likely involves capybaras as reservoirs and Amblyomma and Rhipicephalus ticks as vectors. Thus, domestic animals can serve as key carriers in pathogen dissemination...
October 4, 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/27733423/enhanced-protective-immunogenicity-of-homodimeric-borrelia-burgdorferi-outer-surface-protein-c
#16
Diane G Edmondson, Sabitha Prabhakaran, Steven J Norris, Amy J Ullmann, Joe Piesman, Marc Dolan, Christian Probst, Christiane Radzimski, Winfried Stöcker, Lars Komorowski
Lyme borreliosis is caused by tick-transmitted spirochetes of the Borrelia burgdorferi sensu lato group and is the most common vector-borne disease in the United States and Europe. Outer surface protein C (OspC) is a 23 kDa outer surface lipoprotein expressed during spirochete transmission from the tick to the vertebrate host. In a previous study, we found that immunization with a recombinant disulfide-bridged dimeric form of OspC (D-OspC) stimulates increased antibody responses relative to immunization with commonly employed monomeric OspC...
October 12, 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/27706261/homogeneous-inflammatory-gene-profiles-induced-in-human-dermal-fibroblasts-in-response-to-the-three-main-species-of-borrelia%C3%A2-burgdorferi-sensu-lato
#17
Mariam Meddeb, Wassila Carpentier, Nicolas Cagnard, Sophie Nadaud, Antoine Grillon, Cathy Barthel, Sylvie Josiane De Martino, Benoît Jaulhac, Nathalie Boulanger, Frédéric Schramm
In Lyme borreliosis, the skin is the key site for bacterial inoculation by the infected tick and for cutaneous manifestations. We previously showed that different strains of Borrelia burgdorferi sensu stricto isolated from tick and from different clinical stages of the Lyme borreliosis (erythema migrans, and acrodermatitis chronica atrophicans) elicited a very similar transcriptional response in normal human dermal fibroblasts. In this study, using whole transcriptome microarray chips, we aimed to compare the transcriptional response of normal human dermal fibroblasts stimulated by 3 Borrelia burgdorferi sensu lato strains belonging to 3 main pathogenic species (B...
2016: PloS One
https://www.readbyqxmd.com/read/27706159/molecular-detection-of-tick-borne-pathogens-in-humans-with-tick-bites-and-erythema-migrans-in-the-netherlands
#18
Setareh Jahfari, Agnetha Hofhuis, Manoj Fonville, Joke van der Giessen, Wilfrid van Pelt, Hein Sprong
BACKGROUND: Tick-borne diseases are the most prevalent vector-borne diseases in Europe. Knowledge on the incidence and clinical presentation of other tick-borne diseases than Lyme borreliosis and tick-borne encephalitis is minimal, despite the high human exposure to these pathogens through tick bites. Using molecular detection techniques, the frequency of tick-borne infections after exposure through tick bites was estimated. METHODS: Ticks, blood samples and questionnaires on health status were collected from patients that visited their general practitioner with a tick bite or erythema migrans in 2007 and 2008...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27695100/borrelia-burgdorferi-induces-tlr2-mediated-migration-of-activated-dendritic-cells-in-an-ex-vivo-human-skin-model
#19
Lauren M K Mason, Alex Wagemakers, Cornelis van 't Veer, Anneke Oei, Wouter J van der Pot, Kalam Ahmed, Tom van der Poll, Teunis B H Geijtenbeek, Joppe W R Hovius
Borrelia burgdorferi is transmitted into the skin of the host where it encounters and interacts with two dendritic cell (DC) subsets; Langerhans cells (LCs) and dermal DCs (DDCs). These cells recognize pathogens via pattern recognition receptors, mature and migrate out of the skin into draining lymph nodes, where they orchestrate adaptive immune responses. In order to investigate the response of skin DCs during the early immunopathogenesis of Lyme borreliosis, we injected B. burgdorferi intradermally into full-thickness human skin and studied the migration of DCs out of the skin, the activation profile and phenotype of migrated cells...
2016: PloS One
https://www.readbyqxmd.com/read/27692092/demonstration-of-the-ability-of-a-canine-lyme-vaccine-to-reduce-the-incidence-of-histological-synovial-lesions-following-experimentally-induced-canine-lyme-borreliosis
#20
Deborah A Grosenbaugh, Daniel R Rissi, Paula M Krimer
Lyme disease in dogs can be effectively prevented by vaccination against antigens expressed by the spirochete Borrelia burgdorferi during transmission by the tick vector Ixodes sp. Lyme vaccine efficacy has traditionally been based on indicators of infection following wild-caught tick challenge whereas most other types of vaccine are required to demonstrate protection from clinical signs of disease. In this vaccination-challenge study we sought to demonstrate the ability of a nonadjuvanted, outer surface protein A (OspA) vaccine to protect from infection and to prevent synovial lesions consistent with Borreliosis...
November 1, 2016: Veterinary Immunology and Immunopathology
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