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https://www.readbyqxmd.com/read/28108635/follicular-thyroid-carcinoma-presenting-with-pathological-fracture-of-the-humerus-at-initial-diagnosis
#1
Wanding Yang, WaiSum Cho, Sudip Das, Peter Conboy
Differentiated carcinomas of the thyroid gland usually have a good prognosis with prognosis often discussed in terms of 20 year survival. Nevertheless its 10-year-survival rate decreases when accompanied by distant metastasis. Follicular thyroid cancer (FTC) is the second most common thyroid cancer and usually presents with a solitary thyroid nodule with or without cervical lymphadenopathy. Distance metastasis at initial diagnosis is seldom observed with incidence range from 1 to 9%. In cases of bone metastasis, the incidence is only 2-3% and weight-bearing skeleton is preferentially affected...
January 19, 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28106687/superficial-parotidectomy-plane-for-debulking-surgery-in-kimura-disease
#2
Rohit Sharma
Kimura disease (KD) is a rare chronic inflammatory disorder of unknown etiology representing as solitary or multiple subcutaneous nodules predominantly in the head and neck region. Common sites of involvement are preauricular region, forehead and scalp. The soft tissue localization is often associated with regional lymphadenopathy and enlargement of the major salivary gland. The authors report a patient with KD involving the right parotid and left temporal region managed successfully at our center using a combination of debulking superficial parotidectomy and medicinal therapy...
January 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28106503/ct-and-mri-findings-of-thymic-carcinoid
#3
Aya Shimamoto, Kazuto Ashizawa, Yasuo Kido, Hideyuki Hayashi, Takeshi Nagayasu, Atsushi Kawakami, Hiroshi Mukae, Tomayoshi Hayashi, Mayumi Ohtsubo, Kazuto Shigematsu, Takahiko Nakazono, Hidetake Yabuuchi, Masataka Uetani
OBJECTIVES: To evaluate the computed tomography (CT) and magnetic resonance imaging (MRI) findings of thymic carcinoid and to compare these findings with previously published findings of thymoma. METHODS: Eleven cases of pathologically proven thymic carcinoid were reviewed retrospectively. Three patients had typical carcinoid and eight patients had atypical carcinoid. The characteristics of the tumours and related thoracic abnormalities were assessed in each case on CT and/or MRI by two chest radiologists...
January 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28106480/radio-pathological-correlation-of-organising-pneumonia-op-a-pictorial-review
#4
Mohammad Zare Mehrjardi, Shahram Kahkouee, Mihan Pourabdollah
Since the description of cryptogenic organising pneumonia (COP) in 1983 by Davison et al. and the subsequent report on bronchiolitis obliterans organising pneumonia (BOOP) by Epler et al., some reports have been published regarding the imaging features of organising pneumonia (OP). In this pictorial review, we aim to describe different manifestations of OP on high-resolution computed tomography (HRCT) accompanied by their histopathological correlations for a better comprehension of the radiological findings pathomechanism...
January 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28105551/elevated-serum-igg4-levels-in-diagnosis-and-treatment-response-in-patients-with-idiopathic-retroperitoneal-fibrosis
#5
L G Pelkmans, T R Hendriksz, P J Westenend, H J Vermeer, E F H van Bommel
Idiopathic retroperitoneal fibrosis (iRPF) may be a manifestation of IgG4-related disease. Measuring serum IgG4 (sIgG4) may be of value in monitoring iRPF, but this has scarcely been evaluated. It is unknown if tamoxifen (TMX) affects sIgG4 levels. We performed a prospective inception cohort study of 59 patients with untreated (re)active iRPF stratified by elevated (>1.4 g/L) or normal sIgG4 level. Changes in sIgG4 levels following TMX initiation and, if treatment failed, during subsequent corticosteroid (CS) treatment were analyzed...
January 19, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28105362/pre-treatment-serum-inflammatory-cytokines-as-survival-predictors-of-patients-with-nasopharyngeal-carcinoma-receiving-chemoradiotherapy
#6
Adel F Al-Kholy, Omminea A Abdullah, Mamdouh Z Abadier, Manal M Hassaan, Mohamed F Shindy, Dalia M Nor El-Dien, Ali Hasaneen
The present study aimed to examine the predictability of pre-treatment serum levels of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α for determining the outcome of patients with nasopharyngeal carcinoma (NPC) assigned for chemoradiotherapy. A total of 35 patients with NPC were subjected to clinical examination and evaluation of performance status using Karnofsky scoring. Nasopharyngoscopy was performed for evaluation and to obtain a biopsy. Blood samples were obtained pre- and post-treatment for polymerase chain reaction quantitative estimation of Epstein-Barr virus (EBV) DNA plasma load and enzyme-linked immunosorbent assay for estimation of serum cytokines...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28104720/when-dizziness-becomes-sinister-oropharyngeal-carcinoma-presenting-as-a-paraneoplastic-neurological-disorder
#7
Li Yong, Panagiotis Asimakopoulos, Colin Mumford, Ioanna Fragkandrea Nixon
Paraneoplastic neurological disorders are uncommon presentations of head and neck cancers. We present a case of a 68-year-old male patient who presented with dizziness, nausea and memory problems. MRI of his brain showed bilateral cerebellar leptomeningeal enhancing signal abnormality with cervical lymphadenopathy. CT imaging of his neck raised the suspicion of a tonsillar primary, which was later confirmed on biopsy. His poorly differentiated HPV positive squamous cell carcinoma was treated with chemoradiotherapy...
January 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28102963/diagnostic-value-of-endobronchial-ultrasound-elastography-for-the-differentiation-of-benign-and-malignant-intrathoracic-lymph-nodes
#8
Potjanee Korrungruang, Viboon Boonsarngsuk
BACKGROUND AND OBJECTIVE: Endobronchial ultrasound (EBUS) findings can be used for benign/malignant differentiation of lymph nodes (LNs). Recently, EBUS elastography has been introduced as a complementary modality in the evaluation of intrathoracic lymphadenopathy. We evaluated the ability of EBUS elastography to differentiate between benign and malignant LNs. METHODS: A prospective study was conducted on patients sent for evaluation of intrathoracic lymphadenopathy...
January 19, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28101735/urethral-carcinoma-in-situ-recognition-and-management
#9
Ricardo H Berjeaut, Maliza D I Persaud, Nikolai Sopko, Arthur L Burnett
PURPOSE: Urethral carcinoma in situ (CIS) is an uncommon malignancy that is poorly described in the published literature and is often under-recognized in the clinical setting. This short case series reports some challenges associated with the recognition and management of this disease. METHODS: A retrospective chart review was done over a 12-year period of patients presenting with urethral cancer to the Johns Hopkins Hospital. Four patients were identified with CIS of the anterior urethra, and their demographic and clinical data were recorded...
January 18, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28101723/role-of-high-resolution-computerized-tomography-chest-in-identifying-tubercular-etiology-in-patients-diagnosed-as-eales-disease
#10
Ranju Kharel Sitaula, Vandana Iyer, Veena Noronha, Parthopratim Dutta Majumder, Jyotirmay Biswas
BACKGROUND: The high resolution computerized tomography of chest is an important diagnostic imaging tool to identify any pulmonary tubercular lesion. It's role in Eales' disease to identify any possible association with pulomonary tuberculosis has not been studied earlier. So, this study was conducted to assess the role of high resolution computerized tomography (HRCT) chest in identifying tuberculous etiology in Eales' disease. RESULTS: It was a retrospective study conducted at a tertiary care eye hospital in South India between January 2009 and October 2014 were included...
December 2017: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/28100949/rosai-dorfman-disease-presenting-with-recurrent-unilateral-submandibular-lymph-adenitis-a-case-report
#11
Vipan Kumar, J S Bhandari, Sukirty Awasthi, Mohammad Rashid, Ankita Sharma
Rosai-Dorfman Disease (RDD) is a rare disease of unknown aetiology, initially described as a separate entity in 1969 by Rosai and Dorfman. We describe here a case of RDD presenting with acute, recurrent lymphadenitis and massive lymphadenopathy. The patient's good response to the antibiotics was a false pointer towards infective pathology. The repeated fine needle aspiration cytology was inconclusive or suggested nonspecific reactive hyperplasia. The excision biopsy confirmed the diagnosis of RDD and was supported by immune-histochemistry for S-100 antigen...
December 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28098116/membranous-glomerulopathy-and-massive-cervical-lymphadenopathy-due-to-immunoglobulin-g4-disease
#12
Kamel El-Reshaid, Shaikha Al-Bader, John Madda
A 32-year-old male presented with acute and severe nephrotic syndrome as well as massive right cervical lymphadenopathy for <2 years. Computed tomography scan of the chest, abdomen, and pelvis did not reveal any lymphadenopathy. Histopathology and immunohistochemical testing of his lymph node biopsy showed infiltrate enriched with immunoglobulin G4 (IgG4)-positive plasma cells. His kidney biopsy showed granular membranous deposits of IgG4 in the basement membrane without interstitial infiltrate. Antiphospholipid 2 receptor antibodies were absent excluding its "idiopathic" nature...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28097116/kikuchi-fujimoto-disease-misdiagnosed-as-relapse-of-the-infection-after-treatment-of-periprosthetic-hip-joint-infection
#13
Kyung-Keun Min, Byung-Woo Min, Kyung-Jae Lee, Jung-Hoon Choi
Periprosthetic joint infection (PJI) of the hip can be difficult to treat and can lead to a number of problems including: i) severe functional decline of the hip joint and ii) increasing financial burden for patients due to long treatment periods and the need for repeated surgical interventions. Because there is risk of inadequate control of infection or relapse of a preexisting infection following the treatment of PJI through surgery, it is important to closely observe clinical symptoms such as systemic fever...
December 2016: Hip & Pelvis
https://www.readbyqxmd.com/read/28095804/pulmonary-manifestations-in-niemann-pick-type-c-disease-with-mutations-in-npc2-gene-case-report-and-review-of-literature
#14
Jayesh Sheth, Jijo John Joseph, Krati Shah, Mamta Muranjan, Mehul Mistri, Frenny Sheth
BACKGROUND: Niemann-Pick disease type C (NPC) is an inherited metabolic disorder; due to defect in cellular cholesterol trafficking. It is clinically a heterogeneous disease with variable age of onset with multiple organ systems being involved. NPC1 gene is involved in 95% cases where as remaining ~5% cases are linked with NPC2 gene. CASE PRESENTATION: Case-1, a 14-months-old female presented with recurrent respiratory distress, failure to thrive and hepatosplenomegaly...
January 17, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28094456/waldenstr%C3%A3-m-macroglobulinemia-2017-update-on-diagnosis-risk-stratification-and-management
#15
Morie A Gertz
: Disease Overview: Waldenström macroglobulinemia (WM) is a lymphoplasmacytic lymphoma with immunoglobulin M (IgM) monoclonal protein. Clinical features include anemia, thrombocytopenia, hepatosplenomegaly, lymphadenopathy, and rarely hyperviscosity. DIAGNOSIS: Presence of IgM monoclonal protein associated with ≥10% clonal lymphoplasmacytic cells in bone marrow confirms the diagnosis. The L265P mutation in MYD88 is detectable in more than 90% of patients. Risk Stratification: Age, hemoglobin level, platelet count, β2 microglobulin, and monoclonal IgM concentrations are characteristics required for prognosis...
February 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28088598/are-the-current-guidelines-for-the-surgical-management-of-intraductal-papillary-mucinous-neoplasms-of-the-pancreas-adequate-a-multi-institutional-study
#16
Gregory C Wilson, Shishir K Maithel, David Bentrem, Daniel E Abbott, Sharon Weber, Clifford Cho, Robert Cg Martin, Charles R Scoggins, Hong Jin Kim, Nipun B Merchant, David A Kooby, Michael J Edwards, Syed A Ahmad
BACKGROUND: Controversy persists regarding the management of patients with IPMN. International consensus guidelines stratify patients into high risk, worrisome, and low risk categories. STUDY DESIGN: The medical records of 7 institutions were reviewed for patients that underwent surgical management of IPMN between 2000-2015. RESULTS: 324 patients were included in the analysis. 60.4% of patients had main-duct / mixed type, and 39.7% had branch-duct IPMN...
January 11, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28087540/international-evidence-based-consensus-diagnostic-criteria-for-hhv-8-negative-idiopathic-multicentric-castleman-disease
#17
David C Fajgenbaum, Thomas S Uldrick, Adam Bagg, Dale Frank, David Wu, Gordan Srkalovic, David Simpson, Amy Y Liu, David Menke, Shanmuganathan Chandrakasan, Mary Jo Lechowicz, Raymond S M Wong, Sheila Pierson, Michele Paessler, Jean-François Rossi, Makoto Ide, Jason Ruth, Michael Croglio, Alexander Suarez, Vera Krymskaya, Amy Chadburn, Gisele Colleoni, Sunita Nasta, Raj Jayanthan, Christopher S Nabel, Corey Casper, Angela Dispenzieri, Alexander Fosså, Dermot Kelleher, Razelle Kurzrock, Peter Voorhees, Ahmet Dogan, Kazuyuki Yoshizaki, Frits van Rhee, Eric Oksenhendler, Elaine S Jaffe, Kojo S J Elenitoba-Johnson, Megan S Lim
Human Herpesvirus-8(HHV-8)-negative, idiopathic multicentric Castleman disease (iMCD) is a rare and life-threatening disorder involving systemic inflammatory symptoms, polyclonal lymphoproliferation, cytopenias, and multiple organ system dysfunction due to a cytokine storm often including interleukin-6. iMCD accounts for one-third to one-half of all cases of MCD and can occur in individuals of any age. Accurate diagnosis is challenging, as no standard diagnostic criteria or diagnostic biomarkers currently exist, and there is significant overlap with malignant, autoimmune, and infectious disorders...
January 13, 2017: Blood
https://www.readbyqxmd.com/read/28087391/clonal-cytogenetic-abnormalities-are-predictor-in-developing-non-hodgkin-lymphomas
#18
Ying Wang, Yi Xiao, Xiangyu Meng, Heng Zhang, Qinlu Li, Fankai Meng, Lifang Huang, Chunrui Li, Jianfeng Zhou
Pathological analysis is the cornerstone for diagnosing malignant lymphoma. Status of cytogenetic abnormalities is frequently left unexamined if no evidence of malignancy is found in pathological analysis. In this study, we presented 3 cases in which clonal cytogenetic abnormalities were detected but morphological alterations of the same tissue did not support malignant non Hodgkin lymphoma at the first lymph node biopsy. Case 1 is a 55-year-old female with lymphadenopathy neoplastic process confirmed by flow cytometry and polymerase chain reaction (PCR)...
January 10, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28079748/clinical-characteristics-of-herpes-simplex-virus-urethritis-compared-with-chlamydial-urethritis-among-men
#19
Jason J Ong, Anna N Morton, Helen R Henzell, Karen Berzins, Julian Druce, Christopher K Fairley, Catriona S Bradshaw, Tim Rh Read, Jane S Hocking, Marcus Y Chen
BACKGROUND: The aim of this study was to ascertain the clinical characteristics associated with herpes simplex virus (HSV) urethritis in men and to compare those with chlamydial urethritis. METHODS: We compared clinical and laboratory data from men diagnosed with polymerase chain reaction confirmed HSV urethritis with those of men with chlamydial urethritis presenting to Melbourne Sexual Health Centre between 2000 and 2015. RESULTS: Eighty HSV urethritis cases were identified: 55 (68%, 95% confidence interval, 58-78) were by HSV-1 and 25 (32%, 95% confidence interval, 22-42) by HSV-2...
February 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28076993/evaluation-of-clinical-and-serological-findings-for-diagnosis-of-cutaneous-anthrax-infection-after-an-outbreak
#20
Duygu Gulseren, Serap Süzük-Yıldız, Bekir Çelebi, Selçuk Kılıç
PURPOSE: Anthrax, caused by the bacterium Bacillus anthracis, is one of the oldest documented infectious diseases in both livestock and humans.We aimed to evaluate clinical findings and risk factors of patients with cutaneous anthrax infection and report anti-lethal factor (LF) IgG and anti-protective antigene (PA) IgG titers in the serologic diagnosis of disease. METHODS: In this study, serum samples of 18 cutaneous anthrax patients were collected and anti-LF IgG and anti-PA IgG titers were measured by enzyme-linked immunosorbent assay (ELISA)...
January 11, 2017: Cutaneous and Ocular Toxicology
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