Yue Zhang, Xiangyang Li, Leqiang Gao, Xiaomin Dong, Jinglong Xue, Moxuan Zhao, Junhong Xie, Aliekram Niyaz, Lihua Ren, Xianqing Zhou
Decabromodiphenyl ether (BDE-209), a frequently used brominated flame retardant, readily enters the environment and is difficult to degrade with bioaccumulation. BDE-209 could cause male reproductive toxicity, but the regulatory functions of Sertoli cells-secreted factors remain uncertain. In present study, male mice were treated with 75 mg/kg BDE-209 and then stopped exposure for 50 days. Exogenous Glial cell line-derived neurotrophic factor (GDNF), a Sertoli cell-secreted factor, was injected into testes of mice treated with BDE-209 for 50 days to explore the role of GDNF in BDE-209-induced reproductive toxicity...
March 17, 2024: Environmental Pollution