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https://www.readbyqxmd.com/read/29218725/characterization-of-retinal-ganglion-cell-horizontal-cell-and-amacrine-cell-types-expressing-the-neurotrophic-receptor-tyrosine-kinase-ret
#1
Nadia Parmhans, Szilard Sajgo, Jingwen Niu, Wenqin Luo, Tudor Constantin Badea
We report the retinal expression pattern of Ret, a receptor tyrosine kinase for the Glial Derived Neurotrophic Factor (GDNF) family ligands (GFLs), during development and in the adult mouse. Ret is initially expressed in Retinal Ganglion Cells (RGCs), followed by Horizontal Cells (HCs) and Amacrine Cells (ACs), beginning with the early stages of postmitotic development. Ret expression persists in all three classes of neurons in the adult. Using RNA sequencing, immunostaining and random sparse recombination, we show that Ret is expressed in at least three distinct types of ACs, and ten types of RGCs...
December 8, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29208768/caspase-independent-programmed-cell-death-triggers-ca2po4-deposition-in-an-in-vitro-model-of-nephrocalcinosis
#2
Giovanna Priante, Federica Quaggio, Lisa Gianesello, Monica Ceol, Rosalba Cristofaro, Liliana Terrin, Claudio Furlan, Dorella Del Prete, Franca Anglani
Nephrocalcinosis involves the deposition of microscopic crystals in the tubular lumen or interstitium. While the clinical, biochemical and genetic aspects of the diseases causing nephrocalcinosis have been elucidated, little is known about the cellular events in this calcification process. We previously reported a phenomenon involving the spontaneous formation of Ca2PO4 nodules in primary papillary renal cells from a patient with medullary nephrocalcinosis harboring a rare GDNF gene variant. We also demonstrated that cultivating GDNF -silenced HK-2 cells in osteogenic conditions for 15 days triggered Ca2PO4 deposits...
December 5, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29207043/naringenin-induces-laxative-effects-by-upregulating-the-expression-levels-of-c-kit-and-scf-as-well-as-those-of-aquaporin-3-in-mice-with-loperamide-induced-constipation
#3
Jianqiao Yin, Yichao Liang, Dalu Wang, Zhaopeng Yan, Hongzhuan Yin, Di Wu, Qi Su
Constipation is a common affliction which causes discomfort and affects the quality of life of affected individuals. Naringenin (NAR), a natural flavonoid widely found in citrus fruits and tomatoes, has been reported to exhibit various pharmacological effects, such as anti-inflammatory, anti-atherogenic, anti-mutagenic, hepatoprotective and anticancer effects. Increasing evidence has indicated that NAR has potential for use in the treatment of constipation. Thus, the aim of this study was to evaluate the laxative effects of NAR in mice with loperamide-induced (Lop-induced) constipation...
December 1, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29200666/prevention-of-memory-impairment-and-neurotrophic-factors-increased-by-lithium-in-wistar-rats-submitted-to-pneumococcal-meningitis-model
#4
Lutiana R Simões, Roberta R E S Abreu, Jaqueline S Generoso, Jéssica A Goularte, Allan Collodel, Vijayasree Vayalanellore Giridharan, Anitha Christy Sigamani Arumanayagam, Samira S Valvassori, João Quevedo, Tatiana Barichello
The aim of this study was to investigate the effects of lithium on brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial cell line-derived neurotrophic factor (GDNF) expression in the hippocampus and on memory in experimental pneumococcal meningitis. The mood-stabilizer lithium is known as a neuroprotective agent with many effects on the brain. In this study, animals received either artificial cerebrospinal fluid or Streptococcus pneumoniae suspension at a concentration of 5 × 109 CFU/mL...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29198013/short-and-long-term-protective-effects-of-melatonin-in-a-mouse-model-of-sepsis-associated-encephalopathy
#5
Mu-Huo Ji, De-Guo Xia, Lan-Yue Zhu, Xia Zhu, Xiao-Yan Zhou, Jiang-Yan Xia, Jian-Jun Yang
Brain dysfunction is a common complication after sepsis and is an independent risk factor for a poor prognosis, which is partly attributed to the dysregulated inflammatory response and oxidative damage. Melatonin regulates the sleep-wake cycle and also has potent anti-inflammatory and antioxidant properties, yet the protective effects of melatonin on sepsis-induced neurobehavioral dysfunction remain to be elucidated. In the present study, melatonin was administered intraperitoneally daily at a dose of 10 mg/kg for three consecutive days immediately (early treatment) or 7 days (delayed treatment) after sham operation or cecal ligation and puncture (CLP), followed by an additional treatment in drinking water until the end of behavioral tests...
December 2, 2017: Inflammation
https://www.readbyqxmd.com/read/29197384/involvement-of-the-bone-morphogenic-protein-smad-signaling-pathway-in-the-etiology-of-congenital-anomalies-of-the-kidney-and-urinary-tract-accompanied-by-cryptorchidism
#6
Kentaro Mizuno, Akihiro Nakane, Hidenori Nishio, Yoshinobu Moritoki, Hideyuki Kamisawa, Satoshi Kurokawa, Taiki Kato, Ryosuke Ando, Tetsuji Maruyama, Takahiro Yasui, Yutaro Hayashi
BACKGROUND: Congenital anomalies of the kidney and urinary tract (CAKUT), such as renal dysplasia, hydronephrosis, or vesicoureteral reflux, are the most common causes of end-stage renal disease. However, the genetic etiology of CAKUT remains unclear. In this study, we performed whole exome sequencing (WES) to elucidate the genetic etiology of symptomatic CAKUT and CAKUT accompanied by cryptorchidism. METHODS: Three patients with unilateral renal dysplasia accompanied by ipsilateral cryptorchidism were included in this analysis...
December 2, 2017: BMC Urology
https://www.readbyqxmd.com/read/29183737/cross-platform-single-cell-analysis-of-kidney-development-shows-stromal-cells-express-gdnf
#7
Bliss Magella, Mike Adam, Andrew S Potter, Meenakshi Venkatasubramanian, Kashish Chetal, Stuart B Hay, Nathan Salomonis, S Steven Potter
The developing kidney provides a useful model for study of the principles of organogenesis. In this report we use three independent platforms, Drop-Seq, Chromium 10x Genomics and Fluidigm C1, to carry out single cell RNA-Seq (scRNA-Seq) analysis of the E14.5 mouse kidney. Using the software AltAnalyze, in conjunction with the unsupervised approach ICGS, we were unable to identify and confirm the presence of 16 distinct cell populations during this stage of active nephrogenesis. Using a novel integrative supervised computational strategy, we were able to successfully harmonize and compare the cell profiles across all three technological platforms...
November 25, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29180963/spinal-cord-molecular-and-cellular-changes-induced-by-adenoviral-vector-and-cell-mediated-triple-gene-therapy-after-severe-contusion
#8
Andrei A Izmailov, Tatyana V Povysheva, Farid V Bashirov, Mikhail E Sokolov, Filip O Fadeev, Ravil R Garifulin, Boris S Naroditsky, Denis Y Logunov, Ilnur I Salafutdinov, Yuri A Chelyshev, Rustem R Islamov, Igor A Lavrov
The gene therapy has been successful in treatment of spinal cord injury (SCI) in several animal models, although it still remains unavailable for clinical practice. Surprisingly, regardless the fact that multiple reports showed motor recovery with gene therapy, little is known about molecular and cellular changes in the post-traumatic spinal cord following viral vector- or cell-mediated gene therapy. In this study we evaluated the therapeutic efficacy and changes in spinal cord after treatment with the genes encoding vascular endothelial growth factor (VEGF), glial cell-derived neurotrophic factor (GDNF), angiogenin (ANG), and neuronal cell adhesion molecule (NCAM) applied using both approaches...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29176896/aging-related-limit-of-exercise-efficacy-on-motor-decline
#9
Jennifer C Arnold, Mark A Cantu, Ella A Kasanga, Vicki A Nejtek, Evan V Papa, Nicoleta Bugnariu, Michael F Salvatore
Identifying lifestyle strategies and allied neurobiological mechanisms that reduce aging-related motor impairment is imperative, given the accelerating number of retirees and increased life expectancy. A physically active lifestyle prior to old age can reduce risk of debilitating motor decline. However, if exercise is initiated after motor decline has begun in the lifespan, it is unknown if aging itself may impose a limit on exercise efficacy to decelerate further aging-related motor decline. In Brown-Norway/Fischer 344 F1 hybrid (BNF) rats, locomotor activity begins to decrease in middle age (12-18 months)...
2017: PloS One
https://www.readbyqxmd.com/read/29176141/safflower-extract-and-aceglutamide-injection-promoting-recovery-of-peripheral-innervations-via-vascular-endothelial-growth-factor-b-signaling-in-diabetic-mice
#10
Dan Li, You-Gang Chen, Cui-Juan Zhang, Jing Tian, Xia Li
BACKGROUND: Safflower extract and aceglutamide (SA) has been used clinically for the treatment of cerebrovascular diseases such as cerebral embolism, hemorrhage, and mental deterioration. This study aimed to investigate the effect and mechanism of SA injection in the recovery of peripheral innervations of diabetic mice. METHODS: The C57BL/6 male mice were divided into four groups: normal control group (n = 44), diabetic group (n = 44), diabetic + SA group (diabetic mice treated with SA injection, n = 44), and diabetic + SA + vascular endothelial growth factor receptor (VEGFR)1-BL group (diabetic mice treated with SA injection and VEGFR 1 blocking antibody n = 24)...
December 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29167483/encapsulation-of-primary-dopaminergic-neurons-in-a-gdnf-loaded-collagen-hydrogel-increases-their-survival-re-innervation-and-function-after-intra-striatal-transplantation
#11
Niamh Moriarty, Abhay Pandit, Eilís Dowd
Poor graft survival limits the use of primary dopaminergic neurons for neural repair in Parkinson's disease. Injectable hydrogels have the potential to significantly improve the outcome of such reparative approaches by providing a physical matrix for cell encapsulation which can be further enriched with pro-survival factors. Therefore, this study sought to determine the survival and efficacy of primary dopaminergic grafts after intra-striatal delivery in a glial-derived neurotrophic factor (GDNF)-loaded collagen hydrogel in a rat model of Parkinson's disease...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167169/cutting-edge-microangio-ct-new-dimensions-in-vascular-imaging-and-kidney-morphometry
#12
Ruslan Hlushchuk, Cédric Zubler, Sébastien Barré, Carlos Correa Shokiche, Laura Schaad, Raphael Röthlisberger, Monika L Wnuk, Christoph Daniel, Oleksiy Khoma, Stefan A Tschanz, Mauricio Reyes, Valentin Djonov
In the last decades the contrast-enhanced microCT-imaging of whole animal kidney became increasingly important. The visualization was mainly limited to middle-sized vessels. Since modern desktop microCT-scanners provide the necessary detail resolution, we developed an approach for rapid visualization and consistent assessment of kidney vasculature and glomeruli number. This method is based on μAngiofil®, a new polymerizing contrast agent with homogenous X-ray absorption, which provides continuous filling of the complete vasculature and enables correlative imaging approaches...
November 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29164980/role-of-flunarizine-hydrochloride-in-secondary-brain-injury-following-intracerebral-hemorrhage-in-rats
#13
Jianping Niu, Rui Hu
This study aimed to explore the role and mechanism(s) of flunarizine hydrochloride in the intracerebral hemorrhage (ICH) rats. The 32 adult male Sprague Dawley (SD) rats were randomly assigned into four groups: control group, sham group, ICH group, and FLU + ICH group. The effects of flunarizine hydrochloride were assessed on the basis of hematoma volume, blood-brain barrier (BBB) integrity, and brain water content in the ICH rat models. The role of flunarizine hydrochloride in cell recovery was assessed by behavioral scores, quantitative real-time polymerase chain reaction (qRT-PCR), and western blot assay...
November 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29158444/hnf1b-controls-epithelial-organization-and-cell-polarity-during-ureteric-bud-branching-and-collecting-duct-morphogenesis
#14
Audrey Desgrange, Claire Heliot, Ilya Skovorodkin, Saad U Akram, Janne Heikkilä, Veli-Pekka Ronkainen, Ilkka Miinalainen, Seppo J Vainio, Silvia Cereghini
Kidney development depends critically on proper ureteric bud branching giving rise to the entire collecting duct system. The transcription factor HNF1B is required for the early steps of ureteric bud branching. Yet, the molecular and cellular events regulated by HNF1B are poorly understood. We report that specific removal of Hnf1b from the ureteric bud leads to defective cell-cell contacts and apico-basal polarity during the early branching events. High resolution ex vivo imaging combined with a membranous fluorescent reporter strategy show decreased mutant cell-rearrangements during mitosis-associated cell dispersal and severe epithelial disorganisation...
November 20, 2017: Development
https://www.readbyqxmd.com/read/29147602/gdnf-secreted-by-nerves-enhances-pd-l1-expression-via-jak2-stat1-signaling-activation-in-hnscc
#15
Chengzhong Lin, Wei Cao, Zhenhu Ren, Yu Tang, Chunye Zhang, Rong Yang, Yiming Chen, Zheqi Liu, Canbang Peng, Lizhen Wang, Xu Wang, Tong Ji
Programmed death ligand 1 (PD-L1) functions as a key immune inhibitory factor by binding with its receptor, programmed death 1 (PD-1), to induce immune cell dysfunction and escape of the immune system. However, the mechanisms of PD-L1 expression under growth factor stimulation are not well characterized. Here, we demonstrate a novel role for glial cell line-derived neurotrophic factor (GDNF) in upregulating PD-L1 expression in head and neck squamous cell carcinoma (HNSCC). The expression and correlation of PD-L1, GDNF and perineural invasion (PNI) status were evaluated by bioinformatics analysis of TCGA database and IHC assays from 145 HNSCC patients...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29137428/pten-loss-is-associated-with-prostate-cancer-recurrence-and-alterations-in-tumor-dna-methylation-profiles
#16
Milan S Geybels, Min Fang, Jonathan L Wright, Xiaoyu Qu, Marina Bibikova, Brandy Klotzle, Jian-Bing Fan, Ziding Feng, Elaine A Ostrander, Peter S Nelson, Janet L Stanford
Background: Prostate cancer (PCa) with loss of the tumor suppressor gene PTEN has an unfavorable prognosis. DNA methylation profiles associated with PTEN loss may provide further insights into the mechanisms underlying these more aggressive, clinically relevant tumors. Methods: The cohort included patients with clinically localized PCa. Samples taken from the primary tumor were used to determine PTEN genomic deletions using FISH, and to analyze epigenome-wide DNA methylation profiles...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29129392/targeting-obesity-and-cachexia-identification-of-the-gfral-receptor-mic-1-gdf15-pathway
#17
Samuel N Breit, Vicky Wang-Wei Tsai, David A Brown
Macrophage inhibitory cytokine-1/growth differentiation factor 15 (MIC-1/GDF15) is a divergent transforming growth factor (TGFβ) superfamily cytokine implicated in biological and disease processes including metabolism, cancer, and chronic inflammation, but whose receptor has remained elusive. Four laboratories have recently identified GFRAL, an orphan receptor of the glial-derived neurotrophic factor (GDNF) receptor α family, as the receptor for MIC-1/GDF15, signaling though the coreceptor Ret. These data identify a new systemic to central nervous system (CNS) circuit that regulates metabolism in response to stress and which could be targeted to treat both severe obesity and anorexia/cachexia syndrome...
November 9, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/29114949/protective-effect-of-gdnf-engineered-amniotic-fluid-derived-stem-cells-on-the-renal-ischaemia-reperfusion-injury-in-vitro
#18
Jia Wang, Fengzhen Wang, Zhuojun Wang, Shulin Li, Lu Chen, Caixia Liu, Dong Sun
OBJECTIVES: Amniotic fluid-derived stem cells (AFSCs) possessing multilineage differentiation potential are proposed as a novel and accessible source for cell-based therapy and tissue regeneration. Glial-derived neurotrophic factor (GDNF) has been hypothesized to promote the therapeutic effect of AFSCs on markedly ameliorating renal dysfunction. The aim of this study was to investigate whether AFSCs equipped with GDNF (GDNF-AFSCs) had capabilities of attenuating mouse renal tubular epithelial cells (mRTECs) apoptosis and evaluate its potential mechanisms...
November 7, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29113462/simultaneous-transplantation-of-fetal-ventral-mesencephalic-tissue-and-encapsulated-genetically-modified-cells-releasing-gdnf-in-a-hemi-parkinsonian-rat-model-of-parkinson-s-disease
#19
Alberto Perez-Bouza, Stefano Di Santo, Stefanie Seiler, Morten Meyer, Lukas Andereggen, Alexander Huber, Raphael Guzman, Hans R Widmer
Transplantation of fetal ventral mesencephalic (VM) neurons for Parkinson's disease (PD) is limited by poor survival and suboptimal integration of grafted tissue into the host brain. In a 6-hydroxydopamine rat model of PD, we investigated the feasibility of simultaneous transplantation of rat fetal VM tissue and polymer-encapsulated C2C12 myoblasts genetically modified to produce glial cell line-derived neurotrophic factor (GDNF) or mock-transfected myoblasts on graft function. Amphetamine-induced rotations were assessed prior to transplantation and 2, 4, 6 and 9 wk posttransplantation...
September 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29111577/applications-of-acupuncture-therapy-in-modulating-plasticity-of-central-nervous-system
#20
REVIEW
Ling-Yong Xiao, Xue-Rui Wang, Ye Yang, Jing-Wen Yang, Yan Cao, Si-Ming Ma, Tian-Ran Li, Cun-Zhi Liu
OBJECTIVE: Acupuncture is widely applied for treatment of various neurological disorders. This manuscript will review the preclinical evidence of acupuncture in mediating neural plasticity, the mechanisms involved. MATERIALS AND METHODS: We searched acupuncture, plasticity, and other potential related words at the following sites: PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), and VIP information data base. The following keywords were used: acupuncture, electroacupuncture, plasticity, neural plasticity, neuroplasticity, neurogenesis, neuroblast, stem cell, progenitor cell, BrdU, synapse, synapse structure, synaptogenesis, axon, axon regeneration, synaptic plasticity, LTP, LTD, neurotrophin, neurotrophic factor, BDNF, GDNF, VEGF, bFGF, EGF, NT-3, NT-4, NT-5, p75NTR, neurotransmitter, acetylcholine, norepinephrine, noradrenaline, dopamine, monamine...
November 7, 2017: Neuromodulation: Journal of the International Neuromodulation Society
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