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https://www.readbyqxmd.com/read/28088041/the-role-of-the-ifg-and-psts-in-syntactic-prediction-evidence-from-a-parametric-study-of-hierarchical-structure-in-fmri
#1
William Matchin, Christopher Hammerly, Ellen Lau
Sentences encode hierarchical structural relations among words. Several neuroimaging experiments aiming to localize combinatory operations responsible for creating this structure during sentence comprehension have contrasted short, simple phrases and sentences to unstructured controls. Some of these experiments have revealed activation in the left inferior frontal gyrus (IFG) and posterior superior temporal sulcus (pSTS), associating these regions with basic syntactic combination. However, the wide variability of these effects across studies raises questions about this interpretation...
December 18, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28087612/biofilm-formation-and-antimicrobial-resistance-genes-of-coagulase-negative-staphylococci-isolated-from-cows-with-mastitis-in-argentina
#2
Mariela E Srednik, Yannick D N Tremblay, Josée Labrie, Marie Archambault, Mario Jacques, Fernández Cirelli Alicia, Elida R Gentilini
Mastitis affects the health and welfare of dairy cows worldwide. Coagulase-negative staphylococci (CNS) are known to form biofilms and are increasingly recognized as a cause of persistent bovine intramammary infections. A total of 90 CNS isolated from cows with clinical and subclinical mastitis in Argentina from 2008-2014 were identified by PCR-RFLP using the gap gene. Standard microtiter plate assays were used to assess CNS biofilm formation and Staphylococcus haemolyticus species formed the strongest biofilms...
January 12, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28076421/oscillatory-dynamics-supporting-semantic-cognition-meg-evidence-for-the-contribution-of-the-anterior-temporal-lobe-hub-and-modality-specific-spokes
#3
Giovanna Mollo, Piers L Cornelissen, Rebecca E Millman, Andrew W Ellis, Elizabeth Jefferies
The "hub and spoke model" of semantic representation suggests that the multimodal features of objects are drawn together by an anterior temporal lobe (ATL) "hub", while modality-specific "spokes" capture perceptual/action features. However, relatively little is known about how these components are recruited through time to support object identification. We used magnetoencephalography to measure neural oscillations within left ATL, lateral fusiform cortex (FC) and central sulcus (CS) during word-picture matching at different levels of specificity (employing superordinate vs...
2017: PloS One
https://www.readbyqxmd.com/read/28075522/crucial-role-of-carbonic-anhydrase-ix-in-tumorigenicity-of-xenotransplanted-adult-t-cell-leukemia-derived-cells
#4
Kentaro Nasu, Kazunori Yamaguchi, Tomoka Takanashi, Keiichi Tamai, Ikuro Sato, Shoji Ine, Osamu Sasaki, Kennichi Satoh, Nobuyuki Tanaka, Yuetsu Tanaka, Takuya Fukushima, Hideo Harigae, Kazuo Sugamura
Carbonic anhydrase IX (CA9) is a membrane-associated carbonic anhydrase that regulates cellular pH, is upregulated in various solid tumors, and is considered to be a therapeutic target. Here, we describe the essential role of CA9 in the tumorigenicity of cells derived from human adult T-cell leukemia/lymphoma (ATL). We previously established the highly tumorigenic ST1-N6 subline from the ATL-derived ST1 cell line by serial xenotransplantation in NOG mice. In the present study, we first show that CA9 expression is strongly enhanced in ST1-N6 cells...
January 11, 2017: Cancer Science
https://www.readbyqxmd.com/read/28071789/aspirin-triggered-lipoxin-inhibits-atherosclerosis-progression-in-apoe-mice
#5
Marcelo H Petri, Andrés Laguna-Fernandez, Hildur Arnardottir, Craig E Wheelock, Mauro Perretti, Göran K Hansson, Magnus Bäck
BACKGROUND AND PURPOSE: Atherosclerosis is characterized by a chronic non-resolving inflammation in the arterial wall. Aspirin-triggered lipoxin A4 (ATL) is a potent anti-inflammatory mediator, involved in the resolution of inflammation. However, the therapeutic potential of immune targeting by means of ATL in atherosclerosis has not previously been explored. The aim of the present study was to determine the effects of ATL and its receptor Fpr2 on atherosclerosis development and progression in apolipoprotein E (ApoE(-/-) ) deficient mice...
January 10, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28070029/the-relationship-between-scores-and-outcomes-for-polytrauma-patients-in-the-emergency-department-a-case-study
#6
Maria Gioffre-Florio, Letizia Maria Murabito, Carmela Visalli, Alessandra Villari, Floriana Lauritano, Carla Bramanti, Fausto Fama
AIM: Traumas are one of the most relevant pathological events in health care, because of clinical and prognostic relevance. Morbidity and mortality rates are strongly affected by the timely and correct approach to the patient (golden hour). The objective of this study was to investigate the possible influence of the diagnostic time and of the Injury Severity Score (ISS) on outcomes in trauma patients. MATERIAL OF STUDY: Out of a total of 240,833 emergency patients, we observed, 447 polytrauma...
December 29, 2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28067877/dismal-outcome-of-allogeneic-hematopoietic-stem-cell-transplantation-for-relapsed-adult-t-cell-leukemia-lymphoma-a-japanese-nation-wide-study
#7
H Fujiwara, S Fuji, A Wake, K Kato, Y Takatsuka, T Fukuda, J Taguchi, N Uchida, T Miyamoto, M Hidaka, Y Miyazaki, T Tomoyose, M Onizuka, M Takanashi, T Ichinohe, Y Atsuta, A Utsunomiya
No abstract text is available yet for this article.
January 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28053037/left-anterior-temporal-lobe-and-bilateral-anterior-cingulate-cortex-are-semantic-hub-regions-evidence-from-behavior-nodal-degree-mapping-in-brain-damaged-patients
#8
Ying Zhao, Luping Song, Junhua Ding, Nan Lin, Qiang Wang, Xiaoxia Du, Rong Sun, Zaizhu Han
: The organizational principles of semantic memory in the human brain are still controversial. Although studies have shown that the semantic system contains hub regions that bind information from different sensorimotoric modalities to form concepts, it is unknown whether there are hub regions other than the anterior temporal lobe (ATL). Meanwhile, previous studies have rarely used network measurements to explore the hubs or correlated network indexes with semantic performance, although the most direct supportive evidence of hubs should come from the network perspective...
January 4, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28050003/effectiveness-of-combined-therapy-with-pirfenidone-and-erythromycin-for-unclassifiable-interstitial-pneumonia-induced-by-htlv-1-associated-bronchioloalveolar-disorder-haba
#9
Naoko Yokohori, Akitoshi Sato, Mizue Hasegawa, Hideki Katsura, Kenzo Hiroshima, Tamiko Takemura
Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus involved in the pathogenesis of adult T-cell leukemia (ATL) and HTVL-1-associated bronchioloalveolar disorder (HABA). The clinical and pathological findings of HABA have been characterized as either a diffuse panbronchiolitis (DPB) pattern or idiopathic interstitial pneumonia (IIP) pattern. Treatments for HABA include corticosteroids for the IIP pattern and erythromycin for the DPB pattern. We herein report a case of HABA-associated unclassifiable interstitial pneumonia that improved with combined therapy with pirfenidone and erythromycin...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28046066/htlv-1-bzip-factor-enhances-t-cell-proliferation-by-impeding-the-suppressive-signaling-of-co-inhibitory-receptors
#10
Haruka Kinosada, Jun-Ichirou Yasunaga, Kazuya Shimura, Paola Miyazato, Chiho Onishi, Tomonori Iyoda, Kayo Inaba, Masao Matsuoka
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL) and inflammatory diseases. To enhance cell-to-cell transmission of HTLV-1, the virus increases the number of infected cells in vivo. HTLV-1 bZIP factor (HBZ) is constitutively expressed in HTLV-1 infected cells and ATL cells and promotes T-cell proliferation. However, the detailed mechanism by which it does so remains unknown. Here, we show that HBZ enhances the proliferation of expressing T cells after stimulation via the T-cell receptor...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28035765/risk-stratification-of-adult-t-cell-leukemia-lymphoma-using-immunophenotyping
#11
Huseini H Kagdi, Maria A Demontis, Paul A Fields, Juan Carlos Ramos, Charles R M Bangham, Graham P Taylor
Adult T-cell leukemia/lymphoma (ATL), a human T-lymphotropic virus type 1 (HTLV-1)-associated disease, has a highly variable clinical course and four subtypes with therapeutic and prognostic implications. However, there are overlapping features between ATL subtypes and between ATL and nonmalignant (non-ATL) HTLV-1 infection complicating diagnosis and prognostication. To further refine the diagnosis and prognosis of ATL, we characterized the immunophenotype of HTLV-1-infected cells in ATL and non-ATL. A retrospective study of peripheral blood samples from 10 HTLV-1-uninfected subjects (UI), 54 HTLV-1-infected patients with non-ATL, and 22 with ATL was performed using flow cytometry...
December 30, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/28034804/whole-body-clonality-analysis-in-an-aggressive-stlv-1-associated-leukemia-atll-reveals-an-unexpected-clonal-complexity
#12
Jocelyn Turpin, Sandrine Alais, Ambroise Marçais, Julie Bruneau, Anat Melamed, Nicolas Gadot, Yuetsu Tanaka, Olivier Hermine, Sandrine Melot, Romain Lacoste, Charles R Bangham, Renaud Mahieux
HTLV-1 causes Adult T cell Leukemia/Lymphoma (ATLL) in humans. We describe an ATL-like disease in a 9 year-old female baboon naturally infected with STLV-1 (the simian counterpart of HTLV-1), with a lymphocyte count over 10(10)/L, lymphocytes with abnormal nuclear morphology, and pulmonary and skin lesions. The animal was treated with a combination of AZT and alpha interferon. Proviral load (PVL) was measured every week. Because the disease continued to progress, the animal was euthanized. Abnormal infiltrates of CD3(+)CD25(+) lymphocytes and Tax-positive cells were found by histological analyses in both lymphoid and non-lymphoid organs...
December 26, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28018680/distinctive-structural-and-effective-connectivity-changes-of-semantic-cognition-network-across-left-and-right-mesial-temporal-lobe-epilepsy-patients
#13
Xiaotong Fan, Hao Yan, Yi Shan, Kun Shang, Xiaocui Wang, Peipei Wang, Yongzhi Shan, Jie Lu, Guoguang Zhao
Occurrence of language impairment in mesial temporal lobe epilepsy (mTLE) patients is common and left mTLE patients always exhibit a primary problem with access to names. To explore different neuropsychological profiles between left and right mTLE patients, the study investigated both structural and effective functional connectivity changes within the semantic cognition network between these two groups and those from normal controls. We found that gray matter atrophy of left mTLE patients was more severe than that of right mTLE patients in the whole brain and especially within the semantic cognition network in their contralateral hemisphere...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/28011931/htlv-1-tax-specific-ctl-epitope-pulsed-dendritic-cell-therapy-reduces-proviral-load-in-infected-rats-with-immune-tolerance-against-tax
#14
Satomi Ando, Atsuhiko Hasegawa, Yuji Murakami, Na Zeng, Natsuko Takatsuka, Yasuhiro Maeda, Takao Masuda, Youko Suehiro, Mari Kannagi
Adult T cell leukemia/lymphoma (ATL), a CD4(+) T cell malignancy with a poor prognosis, is caused by human T cell leukemia virus type 1 (HTLV-1) infection. High proviral load (PVL) is a risk factor for the progression to ATL. We previously reported that some asymptomatic carriers had severely reduced functions of CTLs against HTLV-1 Tax, the major target Ag. Furthermore, the CTL responses tended to be inversely correlated with PVL, suggesting that weak HTLV-1-specific CTL responses may be involved in the elevation of PVL...
December 23, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28006655/cloning-expression-and-purification-of-autolysin-from-methicillin-resistant-staphylococcus-aureus-potency-and-challenge-study-in-balb-c-mice
#15
Setareh Haghighat, Seyed Davar Siadat, Seyed Mehdi Rezayat Sorkhabadi, Abbas Akhavan Sepahi, Mehdi Mahdavi
Staphylococcus aureus (MRSA) is an opportunistic pathogen which causes a variety of clinical diseases and leads to high rates of morbidity and mortality. Development of an effective vaccine appears to be a useful strategy to control the infection. Here, the internal region of atl was cloned into the pET24a plasmid and expressed in E. coli BL21 (DE3). Cloning of atl was confirmed by colony-PCR, enzymatic digestion and sequencing. Protein expressed in E coli, BL21 DE3 and was confirmed with SDS-PAGE and western blot analysis...
December 19, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/28001320/dynamic-multi-echo-dce-and-dsc-mri-in-rectal-cancer-low-primary-tumor-k-trans-and-%C3%AE-r2-peak-are-significantly-associated-with-lymph-node-metastasis
#16
Endre Grøvik, Kathrine Røe Redalen, Tryggve Holck Storås, Anne Negård, Stein Harald Holmedal, Anne Hansen Ree, Sebastian Meltzer, Atle Bjørnerud, Kjell-Inge Gjesdal
PURPOSE: To implement a dynamic contrast-based multi-echo MRI sequence in assessment of rectal cancer and evaluate associations between histopathologic data and the acquired dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) -MRI parameters. MATERIALS AND METHODS: This pilot study reports results from 17 patients with resectable rectal cancer. Dynamic contrast-based multi-echo MRI (1.5T) was acquired using a three-dimensional multi-shot EPI sequence, yielding both DCE- and DSC-data following a single injection of contrast agent...
December 21, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27976683/arabidopsis-myrosinases-link-the-glucosinolate-myrosinase-system-and-the-cuticle
#17
Ishita Ahuja, Ric C H de Vos, Jens Rohloff, Geert M Stoopen, Kari K Halle, Samina Jam Nazeer Ahmad, Linh Hoang, Robert D Hall, Atle M Bones
Both physical barriers and reactive phytochemicals represent two important components of a plant's defence system against environmental stress. However, these two defence systems have generally been studied independently. Here, we have taken an exclusive opportunity to investigate the connection between a chemical-based plant defence system, represented by the glucosinolate-myrosinase system, and a physical barrier, represented by the cuticle, using Arabidopsis myrosinase (thioglucosidase; TGG) mutants. The tgg1, single and tgg1 tgg2 double mutants showed morphological changes compared to wild-type plants visible as changes in pavement cells, stomatal cells and the ultrastructure of the cuticle...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27959967/transfusion-80%C3%A2-c-frozen-blood-products-are-safe-and-effective-in-military-casualty-care
#18
Femke Noorman, Thijs T C F van Dongen, Marie-Christine J Plat, John F Badloe, John R Hess, Rigo Hoencamp
INTRODUCTION: The Netherlands Armed Forces use -80°C frozen red blood cells (RBCs), plasma and platelets combined with regular liquid stored RBCs, for the treatment of (military) casualties in Medical Treatment Facilities abroad. Our objective was to assess and compare the use of -80°C frozen blood products in combination with the different transfusion protocols and their effect on the outcome of trauma casualties. MATERIALS AND METHODS: Hemovigilance and combat casualties data from Afghanistan 2006-2010 for 272 (military) trauma casualties with or without massive transfusions (MT: ≥6 RBC/24hr, N = 82 and non-MT: 1-5 RBC/24hr, N = 190) were analyzed retrospectively...
2016: PloS One
https://www.readbyqxmd.com/read/27959327/the-evolution-of-sex-specific-virulence-in-infectious-diseases
#19
Francisco Úbeda, Vincent A A Jansen
Fatality rates of infectious diseases are often higher in men than women. Although this difference is often attributed to a stronger immune response in women, we show that differences in the transmission routes that the sexes provide can result in evolution favouring pathogens with sex-specific virulence. Because women can transmit pathogens during pregnancy, birth or breast-feeding, pathogens adapt, evolving lower virulence in women. This can resolve the long-standing puzzle on progression from Human T-cell Lymphotropic Virus Type 1 (HTLV-1) infection to lethal Adult T-cell Leukaemia (ATL); a progression that is more likely in Japanese men than women, while it is equally likely in Caribbean women and men...
December 13, 2016: Nature Communications
https://www.readbyqxmd.com/read/27939084/hazard-screening-of-photo-transformation-products-from-pharmaceuticals-application-to-selective-%C3%AE-1-blockers-atenolol-and-metoprolol
#20
Anju Priya Toolaram, Jakob Menz, Tushar Rastogi, Christoph Leder, Klaus Kümmerer, Mandy Schneider
The identification of toxic components in cocktail mixtures of pollutants, their metabolites and transformation products (TPs) generated from environmental and treatment processes remains an arduous task. This study expanded in this area by applying a combination of chemical analytics, a battery of in vitro bioassays and an in silico "testing battery" to UV photolysis mixtures of active pharmaceutical ingredients. The objectives were to understand the toxic nature of the mixtures and to prioritize photo-TPs for risk analysis...
February 1, 2017: Science of the Total Environment
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