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https://www.readbyqxmd.com/read/28432701/ovarian-follicle-development-and-genital-tract-characteristics-in-different-birthweight-gilts-at-150%C3%A2-days-of-age
#1
Frcl Almeida, Aln Alvarenga Dias, L P Moreira, Atl Fiúza, H Chiarini-Garcia
In the last decades, selection for improved prolificacy has resulted in higher litter sizes and has thereby increased the proportion of low birthweight (LW) piglets. It is well documented that LW piglets have lower growth performance, muscle accretion and poor carcass quality. However, little is known about the relations of birthweight with subsequent reproductive performance in gilts. This study investigated the effects of birthweight on reproductive tract and ovarian follicle development in 150-day-old gilts...
April 22, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28424650/the-role-of-the-left-anterior-temporal-lobe-for-unpredictable-and-complex-mappings-in-word-reading
#2
Marilyne Joyal, Simona M Brambati, Robert J Laforce, Maxime Montembeault, Mariem Boukadi, Isabelle Rouleau, Joël Macoir, Sven Joubert, Shirley Fecteau, Maximiliano A Wilson
The anterior temporal lobes (ATLs) have been consistently associated with semantic processing which, in turn, has a key role in reading aloud single words. This study aimed to investigate (1) the reading abilities in patients with the semantic variant of primary progressive aphasia (svPPA), and (2) the relationship between gray matter (GM) volume of the left ATL and word reading performance using voxel-based morphometry (VBM). Three groups of participants (svPPA, Alzheimer's Disease, AD and healthy elderly adults) performed a reading task with exception words, regular words and pseudowords, along with a structural magnetic resonance imaging scan...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28420814/cell-adhesion-molecule-1-cadm1-expressed-on-adult-t-cell-leukemia-lymphoma-cells-is-not-involved-in-the-interaction-with-macrophages
#3
Yoshihiro Komohara, Chaoya Ma, Hiromu Yano, Cheng Pan, Hasita Horlad, Yoichi Saito, Koji Ohnishi, Yukio Fujiwara, Yutaka Okuno, Kisato Nosaka, Shunsuke Shimosaki, Kazuhiro Morishita, Masao Matsuoka, Tomohiko Wakayama, Motohiro Takeya
Cell adhesion molecule 1 (CADM1) is a cell adhesion molecule that is expressed in brain, liver, lung, testis, and some kinds of cancer cells including adult T-cell leukemia/lymphoma (ATLL). Recent studies have indicated the involvement of CADM1 in cell-cell contact between cytotoxic T-lymphocytes and virus infected cells. We previously reported that cell-cell interaction between lymphoma cells and macrophages induces lymphoma cell proliferation. In the present study, we investigated whether CADM1 is associated with cell-cell interaction between several human lymphoma cell lines and macrophages...
April 18, 2017: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/28411522/breaking-the-age-barrier-epilepsy-surgery-in-septuagenarians
#4
Vineet Punia, Ahmed Abdelkader, Andrey Stojic
Resective epilepsy surgery (RES) has traditionally been offered to young patients (<50years). The reservation about offering RES to the elderly is multifactorial with their advanced age and comorbidities being the primary reason. The elderly age group (≥65years of age) is one of the fastest growing populations. The arbitrary age limits for RES need reconsideration in the face of an ever increasing elderly population. Considering such changes in demographics, we report the first case series in the literature of seven septuagenarians who underwent RES in the form of anterior temporal lobectomy (ATL)...
April 12, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28397608/clinical-usefulness-of-fdg-pet-ct-for-the-evaluation-of-various-types-of-adult-t-cell-leukemia
#5
Sawako Nakachi, Masahiro Okada, Satoko Morishima, Yurika Agarie, Sakiko Kitamura, Sachie Uchibori, Shouhei Tomori, Taeko Hanashiro, Natsuki Shimabukuro, Keita Tamaki, Iori Tedokon, Kazuho Morichika, Yukiko Nishi, Takeaki Tomoyose, Kennosuke Karube, Takuya Fukushima, Sadayuki Murayama, Hiroaki Masuzaki
PURPOSE: The aim was to explore undefined useful indices for clinically grading adult T-cell leukemia (ATL) using [(18)F] 2-fluoro-2-deoxyglucose (FDG) - positron emission tomography/computed tomography (PET/CT). METHODS: A total of 28 patients with ATL (indolent, 9; aggressive, 19) were enrolled; all patients with aggressive ATL underwent FDG-PET/CT before chemotherapy. Patients with indolent ATL underwent FDG-PET/CT at the time of suspected disease progression and/or transformation; some received lymph node biopsy...
April 11, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28395640/young-road-fatalities
#6
Liv R Øvstedal, Dagfinn Moe, Atle Dyregrov, Kari Dyregrov
This study presents the findings from in-depth interviews with 24 people from 15 families in Norway who lost their young son or daughter in a traffic accident. Their grief has several dimensions: the loss of a young life, the loss of life quality, the effect on family events and their meaning, and the new responsibilities brought onto family members. For each young fatality, many relatives and friends are affected with a wide range of emotional and socioeconomic consequences. Parents report that grief is more overwhelming during the first few years and never disappears, while over the years they slowly learn to cope with it...
May 2017: Omega
https://www.readbyqxmd.com/read/28392570/human-t-cell-lymphotropic-virus-type-1-and-its-oncogenesis
#7
REVIEW
Lan-Lan Zhang, Jing-Yun Wei, Long Wang, Shi-le Huang, Ji-Long Chen
Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL), a rapidly progressing clonal malignancy of CD4+ T lymphocytes. Exploring the host-HTLV-1 interactions and the molecular mechanisms underlying HTLV-1-mediated tumorigenesis is critical for developing efficient therapies against the viral infection and associated leukemia/lymphoma. It has been demonstrated to date that several HTLV-1 proteins play key roles in the cellular transformation and immortalization of infected T lymphocytes...
April 10, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28389411/complications-after-surgery-for-mesial-temporal-lobe-epilepsy-associated-with-hippocampal-sclerosis
#8
Bertrand Mathon, Vincent Navarro, Franck Bielle, Vi-Huong Nguyen-Michel, Alexandre Carpentier, Michel Baulac, Philippe Cornu, Claude Adam, Sophie Dupont, Stéphane Clemenceau
BACKGROUND: Hippocampal sclerosis is the most common cause of drug-resistant epilepsy amenable for surgical treatment and seizure control. This study aimed to analyze morbidities related to surgery of mesial temporal lobe epilepsy associated with hippocampal sclerosis and to identify possible risk factors for complications. METHODS: A retrospective analysis of postoperative complications was made for 389 operations performed between 1990 and 2015 on patients aged 15 to 67 years (mean 36...
April 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28384193/metabolically-healthy-obese-women-have-longer-telomere-length-than-obese-women-with-metabolic-syndrome
#9
Andrea E Iglesias Molli, Julieta Panero, Patricia C Dos Santos, Claudio D González, Jorge Vilariño, Marta Sereday, Gloria E Cerrone, Irma Slavutsky, Gustavo D Frechtel
INTRODUCTION: Obesity is the principal component in the Metabolic Syndrome (MetS) that determines the progression of metabolic complications. Metabolically healthy obese (MHO) individuals seem to be protected against those complications. Telomere length (TL) as a novel marker of cellular aging had a complex relationship to the MetS. The principal aim of this study was to investigate the TL in MHO, and to study the association between TL and the worsening of the metabolic condition. MATERIAL AND METHODS: We have determined the absolute TL (aTL) in 400 women (mean age of 46...
2017: PloS One
https://www.readbyqxmd.com/read/28383227/what-distinguishes-prolonged-grief-disorder-from-depression
#10
Pål Kristensen, Kari Dyregrov, Atle Dyregrov
Prolonged grief disorder, which is proposed as a new diagnosis in ICD-11, and depression have some similarities but also several key differences. In order to provide the correct help and treatment, it is important for doctors to be able to ascertain whether a person is struggling with prolonged grief or has become depressed following the loss of a loved one.
April 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/28380110/leptomonas-seymouri-and-crithidia-fasciculata-exoantigens-can-discriminate-human-cases-of-visceral-leishmaniasis-from-american-tegumentary-leishmaniasis-ones
#11
Norival Kesper, Marta Maria G Teixeira, José Angelo L Lindoso, Clara Lúcia Barbieri, Eufrosina Setsu Umezawa
Exoantigens (exo) from Leptomonas seymouri and Crithidia fasciculata were used in an enzyme linked immunosorbent assay (ELISA), showing 100% reactivity with sera from visceral leishmaniasis (VL) cases, and no reactivity with American tegumentary leishmaniasis (ATL) ones. Our results have indicated that these exoantigens can be applied in the discrimination of VL and ATL cases.
April 3, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28374287/the-differential-contributions-of-conceptual-representation-format-and-language-structure-to-levels-of-semantic-abstraction-capacity
#12
REVIEW
Gainotti Guido
This paper reviews some controversies concerning the original and revised versions of the 'hub-and-spoke' model of conceptual representations and their implication for abstraction capacity levels. The 'hub-and-spoke' model, which is based on data gathered in patients with semantic dementia (SD), is the most authoritative model of conceptual knowledge. Patterson et al.'s (Nature Reviews Neuroscience, 8(12), 976-987, 2007) classical version of this model maintained that conceptual representations are stored in a unitary 'amodal' format in the right and left anterior temporal lobes (ATLs), because in SD the semantic disorder cuts across modalities and categories...
April 3, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/28365308/quasi-experimental-study-designs-series-paper-10-synthesizing-evidence-for-effects-collected-from-quasi-experimental-studies-presents-surmountable-challenges
#13
Betsy Jane Becker, Ariel M Aloe, Maren Duvendack, T D Stanley, Jeffrey C Valentine, Atle Fretheim, Peter Tugwell
OBJECTIVE: To outline issues of importance to analytic approaches to the synthesis of quasi-experiments (QEs), and to provide a statistical model for use in analysis. STUDY DESIGN AND SETTING: We drew on the literatures of statistics, epidemiology, and social-science methodology to outline methods for synthesis of QE studies. The design and conduct of quasi-experiments, effect sizes from QEs, and moderator variables for the analysis of those effect sizes were discussed...
March 30, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28363733/quasi-experimental-study-designs-series-paper-12-strengthening-global-capacity-for-evidence-synthesis-of-quasi-experimental-health-systems-research
#14
Peter C Rockers, Peter Tugwell, Jeremy Grimshaw, Sandy Oliver, Rifat Atun, John-Arne Røttingen, Atle Fretheim, M Kent Ranson, Karen Daniels, Vera Lucia Luiza, Till Bärnighausen
Evidence from quasi-experimental studies is often excluded from systematic reviews of health systems research despite the fact that such studies can provide strong causal evidence when well-conducted. This article discusses global coordination of efforts to institutionalize the inclusion of causal evidence from quasi-experiments in systematic reviews of health systems research. In particular, we are concerned with identifying opportunities for strengthening capacity at the global- and local-level for implementing protocols necessary to ensure that reviews that include quasi-experiments are consistently of the highest quality...
March 28, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28362252/maxillofacial-trauma-managing-potentially-dangerous-and-disfiguring-complex-injuries
#15
Devjanl Das, Lea Salazar
Patients with maxillofacial trauma require a careful evaluation due to the anatomical proximity of the maxillofacial region to the head and neck. Facial injuries can range from soft-tissue lacerations and nondisplaced nasal fractures to severe, complex fractures, eye injuries, and possible brain injury. Though the Advanced Trauma Life Support (ATLS) guidelines provide a framework for the management of trauma patients, they do not provide a detailed reference for many subtle or complex facial injuries. This issue adds a more comprehensive and systematic approach to the secondary survey of the maxillofacial area and emergency department management of injuries to the face...
April 2017: Emergency Medicine Practice
https://www.readbyqxmd.com/read/28360907/aspirin-the-mechanism-of-action-revisited-in-the-context-of-pregnancy-complications
#16
REVIEW
Angela P Cadavid
Aspirin is one of the most frequently used and cheapest drugs in medicine. It belongs to the non-steroidal anti-inflammatory drugs with a wide range of pharmacological activities, including analgesic, antipyretic, and antiplatelet properties. Currently, it is accepted to prescribe a low dose of aspirin to pregnant women who are at high risk of preeclampsia (PE) because it reduces the onset of this complication. Another pregnancy alteration in which a low dose of aspirin is recommended is the obstetric antiphospholipid syndrome (APS)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28358616/nucleotide-sequence-variations-in-autolysis-genes-of-st59-methicillin-resistant-staphylococcus-aureus-isolates
#17
Lee-Chung Lin, Jwu-Ching Shu, Shih-Cheng Chang, Mao-Cheng Ge, Tsui-Ping Liu, Chien-Wei Chen, Jang-Jih Lu
Biofilm formation is a virulence factor of bacteria. The goal of this study was to understand the mechanisms of biofilm formation by methicillin-resistant Staphylococcus aureus (MRSA). Whole-genome sequencing of eight MRSA strains was performed to identify sequence variations in genes related to biofilm formation. Thirty-one genes involved in MRSA biofilm formation were analyzed and 11 amino acid sequence variations in four genes related to autolysis were found. These variations include E121D and H387 N in ArlS; Q117K, T424S, K428T, A509S, V752E, A754V, and T771A in Atl; T184K in CidC; and D251N in CidR...
March 30, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28357672/overview-of-targeted-therapies-for-adult-t-cell-leukemia-lymphoma
#18
Rihab Nasr, Ambroise Marçais, Olivier Hermine, Ali Bazarbachi
Adult T-Cell Leukemia/lymphoma (ATL) is the first human malignancy associated with a chronic infection by a retrovirus, the human T-cell lymphotropic virus type I (HTLV-I). ATL occurs, after a long latency period, only in about 5% of 10-20 millions infected individuals. ATL has a dismal prognosis with a median survival of less than 1 year, mainly due to its resistance to chemotherapy and to a profound immunosuppression. The viral oncoprotein, Tax, plays a major role in ATL oncogenic transformation by interfering with cell proliferation, cell cycle, apoptosis, and DNA repair...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28357669/expression-of-htlv-1-genes-in-t-cells-using-rna-electroporation
#19
Mariangela Manicone, Francesca Rende, Ilaria Cavallari, Andrea K Thoma-Kress, Vincenzo Ciminale
Human T-cell leukemia virus type 1 (HTLV-1) infects about 20 million people world-wide. Around 5% of the infected individuals develop adult T-cell leukemia (ATL) or a neurological disease termed tropical spastic paraparesis (TSP) after a clinical latency of years to decades. Through the use of two promoters and alternative splicing HTLV-1 expresses at least 12 different proteins. HTLV-1 establishes a life-long persistent infection by inducing the clonal expansion of infected cells, a property largely ascribed to the viral genes Tax and HBZ...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28357658/serological-and-molecular-methods-to-study-epidemiological-aspects-of-human-t-cell-lymphotropic-virus-type-1-infection
#20
Olivier Cassar, Antoine Gessain
We estimated that at least 5-10 million individuals are infected with HTLV-1. Importantly, this number is based on the study of nearly 1.5 billion people living in known human T-cell lymphotropic virus type 1 (HTLV-1) endemic areas, for which reliable epidemiological data are available. However, for some highly populated regions including India, the Maghreb, East Africa, and some regions of China, no consistent data are yet available which prevents a more accurate estimation. Thus, the number of HTLV-1 infected people in the world is probably much higher...
2017: Methods in Molecular Biology
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