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https://www.readbyqxmd.com/read/29242103/the-neural-network-for-face-recognition-insights-from-an-fmri-study-on-developmental-prosopagnosia
#1
Yuanfang Zhao, Zonglei Zhen, Xiqin Liu, Yiying Song, Jia Liu
Face recognition is supported by collaborative work of multiple face-responsive regions in the brain. Based on findings from individuals with normal face recognition ability, a neural model has been proposed with the occipital face area (OFA), fusiform face area (FFA), and face-selective posterior superior temporal sulcus (pSTS) as the core face network (CFN) and the rest of the face-responsive regions as the extended face network (EFN). However, little is known about how these regions work collaboratively for face recognition in our daily life...
December 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/29237064/relationship-between-pemphigus-and-american-tegumentary-leishmaniasis-insights-from-serological-and-genetic-profiles
#2
Priscilla Walsh, Maria J F Brochado, Sebastian Vernal, Aline R Machado, Aline Turatti, Natalia A de Paula, Eduardo A Donadi, Ana Maria Roselino
Background: Antibodies against Leishmania peptides (Lbr-peps) and desmogleins (Dsgs) have been reported in pemphigus foliaceus (PF) and leishmaniasis patients, respectively. We aimed to compare serological and genetic features in a Brazilian region endemic for American tegumentary leishmaniasis (ATL) and pemphigus. Methods: Commercial anti-Dsg ELISA and in-house ELISA with Lbr-peps were used to determine the serological profile, in addition to immunoblotting (IB) and indirect immunofluorescence (IIF) assays...
December 11, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29236616/reply-to-m-l%C3%A3-berg-et-al
#3
Simer Jit Bains, Milada Mahic, Tor Åge Myklebust, Milada Cvancarova Småstuen, Sheraz Yaqub, Liv Marit Dørum, Bjørn Atle Bjørnbeth, Bjørn Møller, Kristoffer Watten Brudvik, Kjetil Taskén
No abstract text is available yet for this article.
February 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29233854/efficacy-of-educational-video-game-versus-traditional-educational-apps-at-improving-physician-decision-making-in-trauma-triage-randomized-controlled-trial
#4
Deepika Mohan, Coreen Farris, Baruch Fischhoff, Matthew R Rosengart, Derek C Angus, Donald M Yealy, David J Wallace, Amber E Barnato
OBJECTIVE: To determine whether a behavioral intervention delivered through a video game can improve the appropriateness of trauma triage decisions in the emergency department of non-trauma centers. DESIGN: Randomized clinical trial. SETTING: Online intervention in national sample of emergency medicine physicians who make triage decisions at US hospitals. PARTICIPANTS: 368 emergency medicine physicians primarily working at non-trauma centers...
December 12, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29230025/regulated-hunting-re-shapes-the-life-history-of-brown-bears
#5
Richard Bischof, Christophe Bonenfant, Inger Maren Rivrud, Andreas Zedrosser, Andrea Friebe, Tim Coulson, Atle Mysterud, Jon E Swenson
Management of large carnivores is among the most controversial topics in natural resource administration. Regulated hunting is a centrepiece of many carnivore management programmes and, although a number of hunting effects on population dynamics, body-size distributions and life history in other wildlife have been observed, its effects on life history and demography of large carnivores remain poorly documented. We report results from a 30-year study of brown bears (Ursus arctos) analysed using an integrated hierarchical approach...
December 11, 2017: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29229342/parahippocampectomy-as-a-new-surgical-approach-to-mesial-temporal-lobe-epilepsy-due-to-hippocampal-sclerosis-a-pilot-randomized-comparative-clinical-trial
#6
Mario Arturo Alonso-Vanegas, Iván D Freire Carlier, Daniel San-Juan, Alma Rosa Martínez NPsych, Carlos Trenado
BACKGROUND AND OBJECTIVE: The parahippocampal gyrus (PHG) plays an important role in the epileptogenic pathways of mTLE-HS, it´s resection could be preventing epileptic seizures with less complications. Evaluate the initial efficacy and safety of anterior temporal lobectomy (ATL), selective amygdalo-hipppocampectomy (SAH) and parahippocampectomy (PHC) surgical approaches in mTLE-HS. METHODS: This was a randomized comparative pilot clinical trial (2008-2011) that included patients with mTLE-HS who underwent: ATL, trans-T3 SAH, and trans-T3 PHC...
December 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29227050/barriers-to-accessing-atls-provider-course-for-junior-doctors-at-a-major-university-hospital-in-south-africa
#7
J J Odendaal, V Y Kong, T Liu, B Sartorius, G V Oosthuizen, D L Clarke
BACKGROUND: Advanced trauma life support (ATLS) is the international standard of care and forms the basis of trauma training in South Africa. Previous local studies demonstrated a low completion rate among junior doctors (JD). This study was designed to determine the reasons and identify possible barriers of JDs to accessing the ATLS course at a major university hospital. METHOD: This was a prospective study utilising a structured survey that included all JDs who were undertaking their internship training...
November 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/29223612/predictive-value-of-focused-assessment-with-sonography-for-trauma-fast-for-laparotomy-in-unstable-polytrauma-egyptians-patients
#8
Adel Hamed Elbaih, Sameh T Abu-Elela
PURPOSE: The emergency physicians face significant clinical uncertainty when multiple trauma patients arrive in the emergency department (ED). The priorities for assessment and treatment of polytrauma patients are established in the primary survey. Focused assessment with sonography for trauma (FAST) is very essential clinical skill during trauma resuscitation. Use of point of care ultrasound among the trauma team working in the primary survey in emergency care settings is lacking in Suez Canal University Hospitals even ultrasound machine not available in ED...
November 23, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29222606/hypothalamic-pituitary-adrenal-hpa-axis-functioning-in-overtraining-syndrome-findings-from-endocrine-and-metabolic-responses-on-overtraining-syndrome-eros-eros-hpa-axis
#9
Flavio A Cadegiani, Claudio E Kater
BACKGROUND: Overtraining syndrome (OTS) results from excessive training load without adequate recovery and leads to decreased performance and fatigue. The pathophysiology of OTS in athletes is not fully understood, which makes accurate diagnosis difficult. Previous studies indicate that alterations in the hypothalamus-pituitary-adrenal (HPA) axis may be responsible for OTS; however, the data is not conclusive. This study aimed to compare, through gold standard and exercise-independent tests, the response of the HPA axis in OTS-affected athletes (OTS group) to healthy physically active subjects (ATL group) and healthy non-active subjects (NCS group)...
December 8, 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/29214123/pay-for-performance-motivation-to-succeed-in-advanced-trauma-life-support-courses-a-question-of-background-or-funding
#10
Roman Klein, Wolfgang Armbruster, Martin Grotz, Bernd Höner, Matthias Münzberg, Paul Alfred Grützner, Christoph Georg Wölfl
Objective: To correlate students' performance with their professional background and motivation to take part in Advanced Trauma Life Support (ATLS) courses. We base our analysis on the self-determination theory that differentiates intrinsic (ambition to perform by individual itself) from extrinsic motivation (incentive by external stimuli). Design: We present a non-blinded, monocentric, non-randomized descriptive study of 376 students taking part in an ATLS course at one course site in Germany. Part of a two-day ATLS course are two written tests; we correlate test scores with background information provided by the students in a questionnaire of 13 items (age, sex, adress, board certification, specialty, subspecialty, position, hospital level of care, hospital operator and hospital participation in trauma network, motivation, funding source, condition of funding)...
2017: GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
https://www.readbyqxmd.com/read/29212930/control-of-htlv-1-infection-by-eliminating-envelope-protein-positive-cells-with-recombinant-vesicular-stomatitis-viruses-encoding-htlv-1-primary-receptor
#11
Kenta Tezuka, Kazu Okuma, Madoka Kuramitsu, Sahoko Matsuoka, Reiko Tanaka, Yuetsu Tanaka, Isao Hamaguchi
Human T-cell leukemia virus type 1 (HTLV-1) infection causes adult T-cell leukemia (ATL), which is frequently resistant to current available therapies and has a very poor prognosis. To prevent the development of ATL among carriers it is important to control HTLV-1-infected cells in infected individuals. Therefore, the establishment of novel therapies with drugs specifically targeting infected cells is urgently required. This study aimed to develop a potential therapy by generating recombinant vesicular stomatitis viruses (rVSVs) that lack an envelope glycoprotein G and instead encode HTLV-1 receptor(s) with human glucose transporter 1 (GLUT1), neuropilin 1 (NRP1), or heparan sulfate proteoglycans (HSPGs) including syndecan 1 (SDC1), designated as VSVΔG-GL, VSVΔG-NP, or VSVΔG-SD, respectively...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29211245/low-dose-systemic-or-intralesional-meglumine-antimoniate-treatment-for-american-tegumentary-leishmaniasis-results-in-low-lethality-low-incidence-of-relapse-and-low-late-mucosal-involvement-in-a-referral-centre-in-rio-de-janeiro-brazil-2001-2013
#12
Lucia Regina Brahim, Cláudia Maria Valete-Rosalino, Liliane de Fátima Antônio, Maria Inês Fernandes Pimentel, Marcelo Rosandiski Lyra, Luiz Eduardo de Carvalho Paes, Ananda Dutra da Costa, Iracema Forni Vieira, Cristina Maria Giordano Dias, Maria Cristina de Oliveira Duque, Mauro Celio de Almeida Marzochi, Armando de Oliveira Schubach
BACKGROUND: American tegumentary leishmaniasis (ATL) is a non-lethal parasitic disease that presents with cutaneous (CL) and mucosal (ML) clinical forms. ATL treatment aims at healing the lesions and preventing the development of the late mucosal form. Systemic meglumine antimoniate (MA) therapy with 10-20 mg Sb5+/kg/day is the first choice of treatment. However, alternative therapies using 5 mg Sb5+/kg/day or intralesional (IL) MA are the usual regimens at the National Institute of Infectious Diseases (NIID), Rio de Janeiro, Brazil...
December 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29202596/12-epi-9-deacetoxyxenicin-new-cytotoxic-diterpenoid-from-a-bornean-soft-coral-xenia-sp
#13
Chin-Soon Phan, Takashi Kamada, Takahiro Ishii, Toshiyuki Hamada, Charles Santhanaraju Vairappan
One new compound, 12-epi-9-deacetoxyxenicin (1) along with a hydroperoxide product, 12-epi-9-deacetoxy-8-hydroperoxyxenicin (2) and two known sesquiterpenoids (3-4) were isolated from a population of Bornean soft coral Xenia sp. The structures of these secondary metabolites were elucidated based on their spectroscopic data. Compounds 1 and 2 showed cytotoxic activity against ATL cell line, S1T. In addition, compound 3 exhibited hyphal inhibition of Lagenidium thermophilum.
December 5, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29198647/isolation-functional-characterization-of-allatotropin-receptor-from-the-cotton-bollworm-helicoverpa-armigera
#14
Fang Zhang, Jun Wang, Kiran Thakur, Fei Hu, Jian-Guo Zhang, Xing-Fu Jiang, Shi-Hen An, Hongbo Jiang, Li Jiang, Zhao-Jun Wei
Insect allatotropin (AT) plays multi-functions including regulation of juvenile hormone synthesis, growth, development and reproduction. In the present study, the full-length cDNA encoding the AT receptor was cloned from the brain of Helicoverpa armigera (Helar-ATR). The ORF of Helar-ATR exhibited the characteristic seven transmembrane domains of the G protein-coupled receptor (GPCR) and was close to the ATR of Manduca sexta in the phylogenetic tree. The Helar-ATR expressed in vertebrate cell lines can be activated by Helar-AT and each Helar-ATL in a dose-responsive manner, in the following order: Helar-ATLI>Helar-ATLII>Helar-AT>Helar-ATLIII...
November 30, 2017: Peptides
https://www.readbyqxmd.com/read/29194453/neural-correlates-of-processing-sentences-and-compound-words-in-chinese
#15
Talat Bulut, Yi-Hui Hung, Ovid Tzeng, Denise H Wu
Sentence reading involves multiple linguistic operations including processing of lexical and compositional semantics, and determining structural and grammatical relationships among words. Previous studies on Indo-European languages have associated left anterior temporal lobe (aTL) and left interior frontal gyrus (IFG) with reading sentences compared to reading unstructured word lists. To examine whether these brain regions are also involved in reading a typologically distinct language with limited morphosyntax and lack of agreement between sentential arguments, an FMRI study was conducted to compare passive reading of Chinese sentences, unstructured word lists and disconnected character lists that are created by only changing the order of an identical set of characters...
2017: PloS One
https://www.readbyqxmd.com/read/29180453/a-hereditary-spastic-paraplegia-associated-atlastin-variant-exhibits-defective-allosteric-coupling-in-the-catalytic-core
#16
John P O'Donnell, Laura J Byrnes, Richard B Cooley, Holger Sondermann
The dynamin-related GTPase atlastin (ATL) catalyzes membrane fusion of the endoplasmic reticulum (ER) and thus establishes a network of branched membrane tubules. When ATL function is compromised, the morphology of the ER deteriorates, and these defects can result in neurological disorders such as hereditary spastic paraplegia (HSP) and hereditary sensory neuropathy (HSN). ATLs harness the energy of GTP hydrolysis to initiate a series of conformational changes that enable homodimerization and subsequent membrane fusion...
November 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29176601/emergence-of-tick-borne-diseases-at-northern-latitudes-in-europe-a-comparative-approach
#17
Atle Mysterud, Solveig Jore, Olav Østerås, Hildegunn Viljugrein
The factors that drive the emergence of vector-borne diseases are difficult to identify due to the complexity of the pathogen-vector-host triad. We used a novel comparative approach to analyse four long-term datasets (1995-2015) on the incidence of tick-borne diseases in humans and livestock (Lyme disease, anaplasmosis and babesiosis) over a geographic area that covered the whole of Norway. This approach allowed us to separate general (shared vector) and specific (pathogen reservoir host) limiting factors of tick-borne diseases, as well as the role of exposure (shared and non-shared pathogens in different hosts)...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29166500/final-diagnosis-of-86-cases-included-in-differential-diagnosis-of-american-tegumentary-leishmaniasis-in-a-brazilian-sample-a-retrospective-cross-sectional-study
#18
Fernanda Tirelli, Sebastian Vernal, Ana Maria Roselino
BACKGROUND: Cutaneous leishmaniasis is distributed worldwide, including Brazil. Its several clinical forms need to be distinguished from other dermatoses. Clinical similarities and lack of a gold standard diagnostic tool make leishmaniasis-like lesions a challenging diagnosis. OBJECTIVES.: To report the final diagnosis of patients primarily suspected of having American tegumentary leishmaniasis (ATL). METHODS.: A retrospective cross-sectional study was conducted on the basis of medical records of 437 patients with clinical suspicion of ATL, registered in electronic hospital system between 1980 and 2013...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29162242/current-concepts-in-spondylopelvic-dissociation
#19
REVIEW
André Luiz Loyelo Barcellos, Vinícius M da Rocha, João Antonio Matheus Guimarães
INTRODUCTION: Spondylopelvic dissociation is an uncommon and complex injury that results from high-energy trauma with axial overloading through the sacrum. Due to the life-threatening nature of these injuries, standard Advanced Trauma Life Support® (ATLS) protocol must be used in the trauma setting as part of the initial management of these patients. The key to diagnosis is a good physical exam coupled with high level of suspicion. Radicular neurological deficits commonly are present in spondylopelvic dissociation (L5's roots) and should be documented for future evaluations...
November 2017: Injury
https://www.readbyqxmd.com/read/29157780/growth-hormone-gh-and-prolactin-responses-to-a-non-exercise-stress-test-in-athletes-with-overtraining-syndrome-results-from-the-endocrine-and-metabolic-responses-on-overtraining-syndrome-eros-eros-stress
#20
Flavio A Cadegiani, Claudio E Kater
OBJECTIVES: Overtraining syndrome (OTS) leads to worsened sports performance and fatigue. The pathophysiology of OTS has not been entirely elucidated, and there is a lack of accurate markers for its diagnosis. Changes in hormonal responses implicated in OTS were stimulated by exercise, which has limited their interpretation. Hence, we aimed to evaluate growth hormone (GH) and prolactin responses to a gold-standard and exercise-independent stimulation test, the insulin tolerance test (ITT)...
November 16, 2017: Journal of Science and Medicine in Sport
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