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https://www.readbyqxmd.com/read/27893618/early-resuscitation-with-lyophilized-plasma-provides-equal-neuroprotection-compared-with-fresh-frozen-plasma-in-a-large-animal-survival-model-of-traumatic-brain-injury-and-hemorrhagic-shock
#1
Ihab Halaweish, Ted Bambakidis, Vahagn C Nikolian, Patrick Georgoff, Peter Bruhn, Patryk Piascik, Lisa Buckley, Ashok Srinivasan, Baoling Liu, Yongqing Li, Hasan B Alam
BACKGROUND: Combined traumatic brain injury (TBI) and hemorrhagic shock (HS) is highly lethal. In previous models of combined TBI + HS, we showed that early resuscitation with fresh frozen plasma (FFP) improves neurologic outcomes. Delivering FFP, however, in austere environments is difficult. Lyophilized plasma (LP) is a logistically superior alternative to FFP, but data are limited regarding its efficacy for treatment of TBI. We conducted this study to determine the safety and long-term outcomes of early treatment with LP in a large animal model of TBI + HS...
December 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27877063/copd-patients-medical-care-and-support-in-greece-during-financial-crisis
#2
George Mitonas, Alexia Juvana, Zoe Daniil, Chryssa Hatzoglou, Konstantinos Gourgoulianis
BACKGROUND: The need to follow a multidisciplinary strategy in chronic obstructive pulmonary disease (COPD) management and rehabilitation in community settings in Greece raises significant questions, given the severe austerity measures being imposed at present. The aim of this study was to investigate the clinical profile of patients with COPD along with the care provided in rural community settings in Greece. METHODS: Two primary health care centers and 200 newly diagnosed patients over a 12-month period were involved in the study...
2016: International Journal of General Medicine
https://www.readbyqxmd.com/read/27852461/the-development-of-intensive-care-in-the-military-environment
#3
REVIEW
Matthew J Roberts
If the history of critical care is to be addressed, the starting point must be the fundamental and defining qualities of intensive care units. These are the concentration of the sickest patients in a defined area of the hospital, staffed by the personnel most able to care for them (by virtue of specialist training), and the application of the most advanced monitoring or therapeutic techniques available at the time. In the military environment, the ability to provide critical care to ill or injured servicemen has developed in tandem with the civilian experience, but the pressures of the austere environment of the battlefield have, at times, held back military medical services from providing the highest level of care that servicemen might deserve and, indeed, expect in civilian life...
October 2016: Journal of Anesthesia History
https://www.readbyqxmd.com/read/27849496/military-medics-insight-into-providing-women-s-health-care-in-deployed-settings
#4
Candy Wilson, Robert Corrigan, Sharon Reese, Angelica Almonte, Danielle Simpson, Amber Wilson
OBJECTIVES: To gain better understanding of the military medics' (Navy Independent Duty Corpsman, Air Force Independent Duty Medical Technician, and Army Health Care Specialist, experiences providing health care for women in the deployed or ship setting. METHODS: The researchers used an exploratory, descriptive design informed by ethnography. A total of 86 individuals participated in the focus group and individual interviews. RESULTS: Three themes were identified: Training Fidelity, Advocate Leader, and The Challenges of Providing Patient Care...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27832843/time-is-the-enemy-mortality-in-trauma-patients-with-hemorrhage-from-torso-injury-occurs-long-before-the-golden-hour
#5
A Q Alarhayem, J G Myers, D Dent, L Liao, M Muir, D Mueller, S Nicholson, R Cestero, M C Johnson, R Stewart, Grant O'Keefe, B J Eastridge
INTRODUCTION: The concept of the "Golden Hour" has been a time-honored tenet of prehospital trauma care, despite a paucity of data to substantiate its validity. Non-compressible torso hemorrhage has been demonstrated to be a significant cause of mortality in both military and civilian settings. We sought to characterize the impact of prehospital time and torso injury severity on survival. Furthermore, we hypothesized that time would be a significant determinant of mortality in patients with higher Abbreviated Injury Scale (AIS) grades of torso injury (AIS ≥ 4) and field hypotension (prehospital SBP ≤ 110 mmHg) as these injuries are commonly associated with hemorrhage...
October 20, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27831480/impact-of-the-2008-global-financial-crisis-on-the-health-of-canadians-repeated-cross-sectional-analysis-of-the-canadian-community-health-survey-2007-2013
#6
Sabrina Nour, Ronald Labonté, Christina Bancej
BACKGROUND: Despite a clear impact on the Canadian economy, little is known about the subsequent health impacts of the 2008 global financial crisis (GFC) in this country. This study fills this gap in knowledge by conducting a repeated cross-sectional analysis of the Canadian Community Health Survey (CCHS). METHODS: Data from 7 cycles (2007-2013) of the CCHS were combined to form a large data set representative of the Canadian working-age population (15-64 years) residing in 1 of 10 provinces...
November 9, 2016: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/27794695/activism-can-help-your-career
#7
Layla Haidrani
Danielle Tiplady says her involvement in student activism has broadened her understanding of her patients' lives: 'Now I have more of an idea of how austerity has affected them.'
September 7, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27756984/cytological-grading-an-alternative-to-histological-grading-in-oral-squamous-cell-carcinoma
#8
Srilekha Namala, Vijay Srinivas Guduru, Anuradha Ananthaneni, Sabitha Devi, Puneeth Horrati Kuberappa, Urmila Udayashankar
BACKGROUND: Micronuclei (MN) in oral exfoliative cells have been shown to indicate a disparaging change in genetic information of the cell. Recent studies showed correlation between the frequency of MN and severity of this damage. Grading of lesions can be used to determine the austerity of this damage. Aims: The aim of this study is to compare the MN frequency in oral exfoliated cells of normal and oral squamous cell carcinoma (OSCC) individuals and to cytologically grade the frequency of MN in cytological smears and to correlate it with histological grading...
July 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27755251/a-quartet-of-american-burn-association-clinical-guidelines-for-austere-condition-burn-care-gestation-collaboration-future-impact-and-post-humus-dedication
#9
James C Jeng
No abstract text is available yet for this article.
October 12, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27734439/fraction-of-inspired-oxygen-delivered-by-elis%C3%A3-e%C3%A2-350-turbine-transport-ventilator-with-a-portable-oxygen-concentrator-in-an-austere-environment
#10
Erwan d'Aranda, Julien Bordes, Boris Bourgeois, Jared Clay, Pierre Esnault, Pierre-Julien Cungi, Philippe Goutorbe, Eric Kaiser, Eric Meaudre
BACKGROUND: Management of critically ill patients in austere environments is a logistic challenge. Availability of oxygen cylinders for the mechanically ventilated patient may be difficult in such a context. One solution is to use a ventilator able to function with an oxygen concentrator (OC). METHODS: We tested two Elisée™ 350 ventilators paired with SeQual Integra 10-OM oxygen concentrators (OC) (Chart Industries, http://www .chartindustries.com) and evaluated the delivered fraction of inspired oxygen (Fio2)...
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/27734434/a-skeletal-traction-technique-for-proximal-femur-fracture-management-in-an-austere-environment
#11
David Lidwell, Colin A Meghoo
Skeletal traction is a useful technique for managing proximal femur fractures in austere environments where fracture stabilization for this injury is difficult. We present a technique and a construct appropriate for field use that facilitates patient evacuation, and we provide guidelines for the use of this technique by an advanced medical provider managing these injuries. The objectives of this article are to enable to reader to (1) recognize the role of skeletal traction in managing proximal femur fractures in an austere environment, (2) identify the key steps in placing transfemoral skeletal traction pins, and (3) identify options and requirements for building a traction construct in resource-limited environments...
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/27722861/physiology-of-yersinia-pestis
#12
Robert R Brubaker
This chapter outlines the physiology of Yersinia pestis with emphasis on identifying unique functions required for tissue invasion and acute disease. These activities are opposed to often incompatible processes expressed by very closely related Yersinia pseudotuberculosis, which causes localized gastrointestinal infection. Gain of new information in Y. pestis entailed lateral transfer of plasminogen activator and anti-phagocytic capsular antigen via the plasmids pPCP and pMT, respectively, and derepression of the pigmentation locus facilitating colonization of the flea vector...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27720165/policy-interventions-related-to-medicines-survey-of-measures-taken-in-european-countries-during-2010-2015
#13
Sabine Vogler, Nina Zimmermann, Kees de Joncheere
BACKGROUND: Policy-makers can use a menu of pharmaceutical policy options. This study aimed to survey these measures that were implemented in European countries between 2010 and 2015. METHODS: We did bi-annual surveys with competent authorities of the Pharmaceutical Pricing and Reimbursement Information network. Additionally, we consulted posters produced by members of this network as well as further published literature. Information on 32 European countries (all European Union Member States excluding Luxembourg; Iceland, Norway, Serbia, Switzerland, Turkey) was included...
September 20, 2016: Health Policy
https://www.readbyqxmd.com/read/27707151/addressing-current-and-future-challenges-for-the-nhs-the-role-of-good-leadership
#14
Lotte Elton
Purpose This paper aims to describe and analyse some of the ways in which good leadership can enable those working within the National Health Service (NHS) to weather the changes and difficulties likely to arise in the coming years, and takes the format of an essay written by the prize-winner of the Faculty of Medical Leadership and Management's Student Prize. The Faculty of Medical Leadership and Management ran its inaugural Student Prize in 2015-2016, which aimed at medical students with an interest in medical leadership...
October 3, 2016: Leadership in Health Services
https://www.readbyqxmd.com/read/27706158/colorimetric-detection-of-plasmodium-vivax-in-urine-using-msp10-oligonucleotides-and-gold-nanoparticles
#15
Yossef Alnasser, Cusi Ferradas, Taryn Clark, Maritza Calderon, Alejandro Gurbillon, Dionicia Gamboa, Uri S McKakpo, Isabella A Quakyi, Kwabena M Bosompem, David J Sullivan, Joseph M Vinetz, Robert H Gilman
Plasmodium vivax is the most prevalent cause of human malaria in the world and can lead to severe disease with high potential for relapse. Its genetic and geographic diversities make it challenging to control. P. vivax is understudied and to achieve control of malaria in endemic areas, a rapid, accurate, and simple diagnostic tool is necessary. In this pilot study, we found that a colorimetric system using AuNPs and MSP10 DNA detection in urine can provide fast, easy, and inexpensive identification of P. vivax...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27694650/national-health-service-principles-as-experienced-by-vulnerable-london-migrants-in-austerity-britain-a-qualitative-study-of-rights-entitlements-and-civil-society-advocacy
#16
Elham Rafighi, Shoba Poduval, Helena Legido-Quigley, Natasha Howard
BACKGROUND: Recent British National Health Service (NHS) reforms, in response to austerity and alleged 'health tourism,' could impose additional barriers to healthcare access for non-European Economic Area (EEA) migrants. This study explores policy reform challenges and implications, using excerpts from the perspectives of non-EEA migrants and health advocates in London. METHODS: A qualitative study design was selected. Data were collected through document review and 22 in-depth interviews with non-EEA migrants and civil-society organisation representatives...
May 8, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/27688716/successful-implementation-of-a-multicountry-clinical-surveillance-and-data-collection-system-for-ebola-virus-disease-in-west-africa-findings-and-lessons-learned
#17
Reshma Roshania, Michaela Mallow, Nelson Dunbar, David Mansary, Pranav Shetty, Taralyn Lyon, Kacey Pham, Matthew Abad, Erin Shedd, Anh-Minh A Tran, Sarah Cundy, Adam C Levine
BACKGROUND: The 2014 outbreak of Ebola virus disease (EVD) in West Africa was the largest ever recorded. Starting in September 2014, International Medical Corps (IMC) managed 5 Ebola treatment units (ETUs) in Liberia and Sierra Leone, which cumulatively cared for about 2,500 patients. We conducted a retrospective cohort study of patient data collected at the 5 ETUs over 1 year of operations. METHODS: To collect clinical and epidemiological data from the patient care areas, each chart was either manually copied across the fence between the high-risk zone and low-risk zone, imaged across the fence, or imaged in the high-risk zone...
September 28, 2016: Global Health, Science and Practice
https://www.readbyqxmd.com/read/27687211/tissue-metabolism-and-host-microbial-interactions-in-the-intestinal-mucosa
#18
Carlene Chun, Leon Zheng, Sean P Colgan
In recent years, studies in the gastrointestinal (GI) mucosa have taught us a number of important lessons related to tissue oxygenation and metabolism in health and disease. The highly vascularized mucosa lies immediately adjacent to an anaerobic lumen containing trillions of metabolically active microbes (i.e. the microbiome) that results in one of the more austere tissue microenvironments in the body. These studies have also implicated a prominent role for oxygen metabolism and hypoxia in inflammation, so called "inflammatory hypoxia", that results from the activation of multiple oxygen consuming enzymes...
September 28, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27682551/how-wages-compare
#19
James Buchan
In the autumn, the NHS Pay Review Body (RB) will take evidence from government, employers and nurses' unions. It will then deliberate before making recommendations on what should be a pay rise in April 2017. But as NHS nurses know only too well, this supposedly independent system has been compromised by top down pay freezes initiated by the Westminster government as part of its 'austerity' measures.
September 28, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27671229/intraluminal-delivery-of-thrombospondin-2-small-interfering-rna-inhibits-the-vascular-response-to-injury-in-a-rat-carotid-balloon-angioplasty-model
#20
Thomas C F Bodewes, Joel M Johnson, Michael Auster, Cindy Huynh, Sriya Muralidharan, Mauricio Contreras, Frank W LoGerfo, Leena Pradhan-Nabzdyk
In an effort to inhibit the response to vascular injury that leads to intimal hyperplasia, this study investigated the in vivo efficacy of intraluminal delivery of thrombospondin-2 (TSP-2) small interfering RNA (siRNA). Common carotid artery (CCA) balloon angioplasty injury was performed in rats. Immediately after denudation, CCA was transfected intraluminally (15 min) with one of the following: polyethylenimine (PEI)+TSP-2 siRNA, saline, PEI only, or PEI+control siRNA. CCA was analyzed at 24 h or 21 d by using quantitative real-time PCR and immunohistochemistry...
September 26, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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