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antinuclear antibody 1:40

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https://www.readbyqxmd.com/read/28138914/obstetric-and-perinatal-outcome-in-anti-ro-ssa-positive-pregnant-women-a-prospective-cohort-study
#1
Nuria Martínez-Sánchez, Sergio Pérez-Pinto, Ángel Robles-Marhuenda, Francisco Arnalich-Fernández, María Martín Cameán, Edurne Hueso Zalvide, Jose Luis Bartha
: Anti-Ro/SS-A is one specific type of antinuclear antibodies. They are in the majority of cases associated with primary Sjögren syndrome (SS) but also in Systemic Lupus Erythematosus (SLE), rheumatoid arthritis (RA), and in healthy people. During pregnancy, they are mainly associated to congenital heart block (CHB) and neonatal lupus (NL). The aim of this study was to compare the rate of maternal and fetal complications between a series of anti-Ro/SS-A positive pregnant women prospectively followed...
January 30, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28128085/antiphospholipid-syndrome-with-anti%C3%AE-2glicoprotein-1-antibodies-as-the-cause-of-recurrent-tibial-vein-thrombosis-in-sapho-syndrome
#2
Hanna Przepiera-Będzak, Marek Brzosko
The antiphospholipid antibody syndrome is defined by the presence of antiphospholipid antibodies in patients with recurrent venous or arterial thromboembolism (1). SAPHO syndrome is a rare disease, characterized by specific clinical manifestations of synovitis, acne pustulosis, hyperostosis, and osteitis. It is a disease that manifests with a combination of osseous and articular manifestations associated with skin lesions (2). Venous thrombosis complicating SAPHO syndrome seems to be uncommon with an unclear pathogenesis (3-9)...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28034821/prevalence-of-autoantibodies-in-the-course-of-gaucher-disease-type-1-a-multicenter-study-comparing-gaucher-disease-patients-to-healthy-subjects
#3
Christine Serratrice, Nesma Bensalah, Guillaume Penaranda, Nathalie Bardin, Nadia Belmatoug, Agathe Masseau, Christian Rose, Olivier Lidove, Fabrice Camou, François Maillot, Vanessa Leguy, Nadine Magy-Bertrand, Isabelle Marie, Patrick Cherin, Monia Bengherbia, Sebastian Carballo, José Boucraut, Jacques Serratrice, Marc Berger, Denis Verrot
OBJECTIVES: Type 1 Gaucher disease may be related to the presence of autoantibodies. Their clinical significance is questioned. Primary Endpoint was to compare the prevalence of autoantibodies in type 1 Gaucher disease patients with healthy subjects, seeking correlations with autoimmune characteristics. Secondary endpoints were to determine whether patients with autoantibodies reported autoimmunity-related symptoms and if genotype, splenectomy or treatment influenced autoantibodies presence...
December 26, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28033275/pregnancy-complicated-with-agranulocytosis
#4
Hai Wang, Jiang-Li Sun, Zheng-Liang Zhang, Hong-Hong Pei
RATIONALE: Pregnancy is a complicated physiological process. Physiological leukocytosis often takes place and it is primarily related to the increased circulation of neutrophils, especially during the last trimester of pregnancy. Noncongenital agranulocytosis during pregnancy is rare and reported only occasionally, while in most of the cases, the agranulocytosis has already occurred prior to pregnancy or induced by identified factors such as antibiotics, antithyroid agents, or cytotoxic agents...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27862036/association-of-%C3%AE-1-adrenergic-m2-muscarinic-receptor-autoantibody-with-occurrence-and-development-of-nonvalvular-atrial-fibrillation
#5
Bing Hu, Yanxiang Sun, Sha Li, Jie Sun, Tong Liu, Zidi Wu, L I Feng
BACKGROUND: Atrial fibrillation (AF) is the most common sustained arrhythmia and is independently associated with increased risk of stroke and death. Although the exact mechanisms of AF are not completely elucidated, a large number of evidences demonstrate that autoimmunity may play an important role in the initiation, the progression, and the maintenance of AF. In this study, we aimed to compare anti-β1-adrenergic receptor autoantibody (anti-β1-R) and anti-M2-muscarinic receptor autoantibody (anti-M2-R) levels between nonvalvular AF patients and healthy control subjects...
December 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27660485/streptococcus-pneumoniae-sepsis-as-the-initial-presentation-of-systemic-lupus-erythematosus
#6
Ilknur Erdem, Senay Elbasan Omar, Ridvan Kara Ali, Hayati Gunes, Aynur Eren Topkaya
OBJECTIVE: Infections are among the most important causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE) but are rare initial presentation of the disease. Therefore, in this study, we describe a case of Streptococcus pneumoniae sepsis in a young woman with previously undiagnosed SLE. CASE REPORT: A 23-year-old female patient was admitted to our outpatient clinic complaining of high fever (40°C), chills, fatigue, generalized myalgia, and cough with brown sputum for 5 days...
2016: International Journal of General Medicine
https://www.readbyqxmd.com/read/27450524/-investigation-of-autoimmunity-markers-during-interferon-alpha-therapy-of-chronic-hepatitis-b-and-c-twenty-years-of-experience
#7
Irena Orságová, Luděk RoŽnovský, Lenka Petroušová, Michaela Konečná, Libuše Kabieszová, Jan Martinek, Alena Kloudová, Ladislav Pavliska
OBJECTIVE: To determine the prevalence of autoimmune parameters in patients with chronic hepatitis B and C (HBV, HCV) treated with conventional or pegylated interferon alpha (IFN) and monitor the development of autoimmune diseases in connection with this treatment. PATIENTS AND METHODS: In the years 1992-2014, autoimmune parameters were evaluated in 324 patients (271 with HCV, 53 with HBV) treated with IFN at the Department of Infectious Diseases in Ostrava. Prior to, during and after completion of IFN treatment, antinuclear antibodies (ANA), antimitochondrial antibodies (AMA), smooth muscle antibodies (SMA), anti-liver/kidney microsomal antibodies (anti-LKM-1), anti-double-stranded DNA antibodies (anti-ds-DNA), antibodies against granulocytes (ANCA), anti-deoxyribonucleoprotein antibodies (anti-DNP), anti-nucleosomes antibodies, rheumatoid factor (RF) and circulating immune complexes (CIC) were determined and clinical manifestations of autoimmune diseases were evaluated...
June 2016: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27432022/prevalence-of-antinuclear-antibodies-in-healthy-lebanese-subjects-2008-2015-a-cross-sectional-study-involving-10-814-subjects
#8
Eddie Racoubian, Reem M Zubaid, Marwa A Shareef, Wassim Y Almawi
Antinuclear antibodies (ANA) are found at varying frequencies in healthy populations, depending on geographical location and ethnic background of participants. The main objective of this study was to determine the prevalence of ANA in healthy Lebanese population in the period 2008-2015. Study subjects comprised 10,851 individuals (3311 males and 7503 females). ANA positivity was determined using immunofluorescence on HEp-2 cells. The prevalence of positive ANA test at a titer of ≥1:100 was 26.4 %, with 696 individuals (6...
September 2016: Rheumatology International
https://www.readbyqxmd.com/read/27228650/antiphospholipid-and-antinuclear-antibodies-in-young-patients-after-myocardial-revascularization-procedures
#9
Adam Mazurek, Teresa Iwaniec, Maria Olszowska, Carlo Perricone, Barbara Widlinska, Piotr Podolec, Jacek Musial, Wojciech Plazak
BACKGROUND: The role of autoimmune factors in the etiology of coronary artery disease (CAD) was suggested in numerous studies but has not been definitively determined. OBJECTIVES: To assess the possible influence of antiphospholipid and antinuclear antibodies on atherosclerosis development in young patients after myocardial revascularization procedures. METHODS: The study group included 39 patients younger than 45 years with CAD who underwent myocardial revascularization...
March 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/27225012/comparison-of-screening-dilution-and-automated-reading-for-antinuclear-antibody-detection-on-hep2-cells-in-the-monitoring-of-connective-tissue-diseases
#10
Anne E Depincé-Berger, Amelie Moreau, Virginie Bossy, Christian Genin, Melanie Rinaudo, Stephane Paul
BACKGROUND: Indirect immunofluorescence plays a major role in the detection of antinuclear antibodies (ANAs) and follow-up of their titers in the context of connective tissue diseases. Given the numerous unfavorable features of the conventional manual reading of HEP2 slides (need of time and expert morphologists for the reading, lack of standardization, subjectivity of the interpretation), the biomedical industry has developed automated techniques of slide preparation and microscope reading...
September 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27166176/ptpn22-polymorphisms-but-not-r620w-were-associated-with-the-genetic-susceptibility-of-systemic-lupus-erythematosus-and-rheumatoid-arthritis-in-a-chinese-han-population
#11
Liang Tang, Yan Wang, Shui Zheng, Meihua Bao, Qingsong Zhang, Jianming Li
OBJECTIVES: The present study aimed to detect a possible association between PTPN22 gene polymorphisms and rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Chinese Han population. METHODS: 7 PTPN22 SNPs were genotyped in 358 patients with RA and 713 patients with SLE, as well as 564 RA controls and 672 SLE controls by Restriction Fragment Length Polymorphism (RFLP). Association analyses were conducted on the whole data set. Significant relationships were also examined between clinical features and SNPs for both RA and SLE...
August 2016: Human Immunology
https://www.readbyqxmd.com/read/27149138/generalized-pyoderma-gangrenosum-associated-with-ulcerative-colitis-successful-treatment-with-infliximab-and-azathioprine
#12
Foteini Chatzinasiou, Dimitrios Polymeros, Maro Panagiotou, Konstadinos Theodoropoulos, Dimitrios Rigopoulos
Pyoderma gangrenosum (PG) is a rare ulcerative skin disease, part of the spectrum of neutrophilic and auto-inflammatory dermatoses. Its pathogenesis is unknown, although immune pathways have been implicated. Lesion biopsies show a predominantly neutrophilic infiltrate. The incidence of PG is uncertain, but it is estimated to be 3-10 per million per year, occurring at any age but most commonly between 20 and 50 years with a possible slightly higher incidence in women. Approximately 50% of patients with PG also have another disease associated with PG...
April 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27149136/paraneoplastic-scleroderma-are-there-any-clues
#13
Hana Jedlickova, Veronika Durčanská, Vladimír Vašků
Dear Editor, Scleroderma associated with neoplasia is rare, with only a small number of cases reported. We describe 4 patients with paraneoplastic scleroderma who were treated at the I. Department of Dermatovenereology, St. Anna Hospital, during the period between 2004 and 2014. The patients were diagnosed with cholangiogenic carcinoma, endometrial carcinoma, prostatic adenocarcinoma, and adenoma of the suprarenal gland. In the case of concurrent scleroderma and tumor, four situations may occur: they can develop independently of each other; scleroderma may be induced by the tumor; the tumor can develop in the scleroderma; or the tumor can be induced by immunosuppressive therapy...
April 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27051100/pulmonary-involvement-in-systemic-sclerosis-a-clinical-profile
#14
A S Deepa, Roopa Premanand Rachel, Priya Ramchandran, Uma Devaraj, S Abhilash Arnold, Vineeta Shobha, George D'souza
BACKGROUND: Systemic sclerosis is a generalized disorder of connective tissue affecting skin and internal organs. Lung involvement accounts for significant morbidity and is a leading cause of mortality in patients. OBJECTIVES: This study intends to study the frequency of occurrence of pulmonary involvement in progressive systemic sclerosis (PSS) and to describe the clinical and radiological picture of pulmonary involvement in PSS. MATERIALS AND METHODS: This was a descriptive cross-sectional study...
March 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/26681000/detection-of-serum-antinuclear-antibodies-in-lymphoma-patients
#15
H Y Zou, X Gu, W Z Yu, Z Wang, M Jiao
We investigated the presence of serum antinuclear antibodies (ANAs) and autoantibodies and their relationship with serum prognostic indicators in lymphoma patients. The study population comprised 127 patients diagnosed with lymphoma and 138 healthy control subjects. The blood samples of the participants were assayed for ANAs by immunofluorescence, and autoantibodies were detected by western blotting. Serum ANAs were detected in 31.5 (40/127) and 6.5% (9/138) of lymphoma patients and control subjects, respectively...
December 11, 2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26597492/nailfold-capillaroscopic-findings-in-primary-sj%C3%A3-gren-s-syndrome-with-and-without-raynaud-s-phenomenon-and-or-positive-anti-ssa-ro-and-anti-ssb-la-antibodies
#16
MULTICENTER STUDY
Hèctor Corominas, Vera Ortiz-Santamaría, Iván Castellví, Mireia Moreno, Rosa Morlà, Teresa Clavaguera, Alba Erra, Silvia Martínez-Pardo, Sergi Ordóñez, Pilar Santo, Patricia Reyner, Maria José González, Oriol Codina, Mario Saul Gelman, Xavier Juanola-Roura, Alex Olivé, Vicenç Torrente-Segarra
The aim of this study was to assess nailfold capillaroscopic (NC) findings in patients with primary Sjögren's syndrome (PSS) with and without Raynaud's phenomenon (RP) as well as in the presence of positive anti-SSA/Ro and anti-SSB/La antibodies. Videocapillaroscopy was performed in 150 patients with PSS. Data collected included demographics, presence of RP, PSS symptoms, antinuclear antibodies, rheumatoid factor, anti-Ro, anti-La, anti-CCP, salivary scintigraphy, labial biopsy, and NC findings. RP was present in 32% of PSS, keratoconjunctivitis sicca in 91%, oral xerosis in 93%, and skin or genital xerosis in 53%...
March 2016: Rheumatology International
https://www.readbyqxmd.com/read/26524640/serum-antinuclear-and-extractable-nuclear-antigen-antibody-prevalence-and-associated-morbidity-and-mortality-in-the-general-population-over-15-years
#17
REVIEW
Carlo Selmi, Angela Ceribelli, Elena Generali, Carlo A Scirè, Fausto Alborghetti, Guido Colloredo, Luisa Porrati, Maria I S Achenza, Maria De Santis, Francesca Cavaciocchi, Marco Massarotti, Natasa Isailovic, Valentina Paleari, Pietro Invernizzi, Torsten Matthias, Alberto Zucchi, Pier Luigi Meroni
The prevalence of ANA and anti-ENA in the general population is not well established, especially their clinical significance in healthy subjects. We herein determined the prevalence and predictive value of serum ANA and anti-ENA for connective tissue diseases (CTD), cancer, and mortality. We took advantage of a randomly selected sample of the 1998 general population (Isola I) consisting of 2828 subjects (53% women, age 43±13 years) from a well-defined Northern Italian area. Serum ANA and anti-ENA were tested on the 2690 samples available in 2012 (Isola II, 50% women, age 58±13 years)...
February 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/26381446/immunoglobulin-g4-associated-autoimmune-hepatitis-later-complicated-by-autoimmune-pancreatitis-a-case-report
#18
Yoji Ishizu, Masatoshi Ishigami, Teiji Kuzuya, Takashi Honda, Kazuhiko Hayashi, Isao Nakano, Yoshiki Hirooka, Hidemi Goto
Immunoglobulin G4 (IgG4)-associated autoimmune hepatitis (AIH) is a new disease entity with elevated levels of serum IgG4 and marked IgG4 positive plasma cell infiltration of the liver, and its clinical course remains unknown. A patient with IgG4-associated AIH who later developed autoimmune pancreatitis (AIP) is reported. A 73-year-old man was admitted to our hospital due to elevated liver transaminase levels, hypergammaglobulinemia and positive antinuclear antibody. A liver biopsy specimen showed severe interface hepatitis with marked lymphoplasmacytic infiltration without damage to the interlobular bile ducts, and a diagnosis of AIH was made...
May 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/26374255/to-chew-or-not-to-chew-that-s-the-question
#19
Halil Yildiz, Mina Komuta, Constanza Monsalve, Peter Starkel, Chantal Lefebvre
A 25-year-old Somalian man was referred to the department of internal medicine because of nausea, vomiting and jaundice of recent onset. On physical examination, he was frankly icteric without clinical signs of chronic liver disease. Laboratory data showed evidence of acute hepatitis. Viral serologic tests for hepatitis A, B, C and E were negative. Antinuclear antibodies (ANA) were positive (titre 1 : 1280; speckled pattern, NV < 1 : 40) as well anti-actin antibodies (titre 75 UA, NV < 20)...
June 2016: Acta Clinica Belgica
https://www.readbyqxmd.com/read/26173506/autoimmune-markers-do-not-impact-clinical-presentation-or-natural-history-of-steatohepatitis-related-liver-disease
#20
Sujan Ravi, Mohamed Shoreibah, Evan Raff, Joseph Bloomer, Donny Kakati, Khalid Rasheed, Ashwani K Singal
BACKGROUND AND AIM: Autoimmune (AI) markers are reported in patients with steatohepatitis-related liver disease. However, their clinical significance is unclear. METHODS: Charts of patients due to alcoholic liver disease (ALD) or nonalcoholic fatty liver disease (NAFLD) were stratified for antinuclear antigen (ANA > 1:80), antismooth muscle antibody (ASMA > 1:40), or antimitochondrial antibody (AMA > 1:20). Study outcomes were patient survival and complications of liver disease...
December 2015: Digestive Diseases and Sciences
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