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Bradykinin receptor

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https://www.readbyqxmd.com/read/29775649/expression-and-function-of-tlr4-induced-b1r-bradykinin-receptor-on-cardiac-fibroblasts
#1
Claudia Muñoz-Rodríguez, Samuel Fernández, José Miguel Osorio, Francisco Olivares, Renatto Anfossi, Samir Bolivar, Claudio Humeres, Pía Boza, Raúl Vivar, Viviana Pardo-Jimenez, Karen E Hemmings, Neil A Turner, Guillermo Díaz-Araya
Cardiac fibroblasts (CF) are key cells for maintaining extracellular matrix (ECM) protein homeostasis in the heart, and for cardiac repair through CF-to-cardiac myofibroblast (CMF) differentiation. Additionally, CF play an important role in the inflammatory process after cardiac injury, and they express Toll like receptor 4 (TLR4), B1 and B2 bradykinin receptors (B1R and B2R) which are important in the inflammatory response. B1R and B2R are induced by proinflammatory cytokines and their activation by bradykinin (BK: B2R agonist) or des-arg-kallidin (DAKD: B1R agonist), induces NO and PGI2 production which is key for reducing collagen I levels...
May 15, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29772567/the-renin-angiotensin-system-not-the-kinin-kallikrein-system-affects-post-exercise-proteinuria
#2
Günnur Koçer, Filiz Basralı, Oktay Kuru, Ümit Kemal Şentürk
BACKGROUND/AIMS: Temporary proteinuria post-exercise is common and is caused predominantly by renal haemodynamic alterations. One reason is up-regulation of angiotensin II (Ang II) due to the reducing effect of angiotensin-converting enzyme (ACE) inhibitors. However, another, ignored, reason could be the kininase effect of ACE inhibition. This study investigated how ACE inhibition reduces post-exercise proteinuria: by either Ang II up-regulation inhibition or bradykinin elevation due to kininase activity inhibition...
May 17, 2018: Nephron
https://www.readbyqxmd.com/read/29765540/could-a-plant-derived-protein-potentiate-the-anticancer-effects-of-a-stem-cell-in-brain-cancer
#3
Camila Ramalho Bonturi, Helena Motaln, Mariana Cristina Cabral Silva, Bruno Ramos Salu, Marlon Vilela de Brito, Luciana de Andrade Luz Cost, Heron Fernandes Vieira Torquato, Natalia Neto Dos Santos Nunes, Edgar Julian Paredes-Gamero, Tamara Lah Turnšek, Maria Luiza Vilela Oliva
Glioblastoma is the most aggressive brain tumor with poor overall survival bellow 2 years. The natural compounds with anti-cancer properties, are thus gaining attention for possible adjuvant GBM treatment. In various cancer models Enterolobium contortisiliquum Trypsin Inhibitor (EcTI) proved to have anti-cancer effects. Here, we investigated the EcTI effects on GBM U87 cells and on mesenchymal stem cells (MSC) compared to their direct coculture (MSC/U87). MSC are present in tumor stroma, modulating GBM cells phenotype, and also represent potential drug delivery vehicle due to their tumor tropism...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29757016/icatibant-for-the-treatment-of-hereditary-angioedema-with-c1-inhibitor-deficiency-in-adolescents-and-in-children-aged-over-2-years
#4
Henriette Farkas, Kinga Viktória Kőhalmi
Hereditary angioedema (HAE) due to C1-inhibitor deficiency (C1-INH-HAE) is a rare disorder with life-threatening complications if untreated. It begins during childhood, and reduces the patient's quality of life. Therefore, the availability of an easily administered agent to relieve unpredictable HAE episodes is indispensable for this age group. Areas covered: Randomized, double-blind, placebo-controlled, open-label extensions and prospective observational studies have proven the safety and efficacy of the subcutaneously administered bradykinin B2 receptor antagonist, icatibant, in the acute treatment of HAE episodes in adult C1-INH-HAE patients...
May 14, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29729940/a-transcriptomic-study-of-hereditary-angioedema-attacks
#5
Giuseppe Castellano, Chiara Divella, Fabio Sallustio, Vincenzo Montinaro, Claudia Curci, Andrea Zanichelli, Erika Bonanni, Chiara Suffritti, Sonia Caccia, Fleur Bossi, Anna Gallone, Francesco Paolo Schena, Loreto Gesualdo, Marco Cicardi
BACKGROUND: Hereditary Angioedema (HAE) due to C1-inhibitor deficiency is a lifelong illness characterized by recurrent acute attacks of localized skin or mucosal edema. An activation of the kallikrein/bradykinin pathway at endothelial cell level has a relevant pathogenetic role in acute HAE attacks. Moreover, other pathways are involved, given the variable clinical expression of the disease in different patients. OBJECTIVE: To explore the involvement of other putative genes in the edema formation...
May 3, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29720566/unexpected-kidney-restricted-role-for-il-17-receptor-signaling-in-defense-against-systemic-candida-albicans-infection
#6
Kritika Ramani, Chetan V Jawale, Akash H Verma, Bianca M Coleman, Jay K Kolls, Partha S Biswas
Kidney injury is a frequent outcome in patients with disseminated Candida albicans fungal infections. IL-17 receptor (IL-17R) signaling is critical for renal protection against disseminated candidiasis, but the identity and function of IL-17-responsive cells in mediating renal defense remains an active area of debate. Using BM chimeras, we found that IL-17R signaling is required only in nonhematopoietic cells for immunity to systemic C. albicans infection. Since renal tubular epithelial cells (RTEC) are highly responsive to IL-17 in vitro, we hypothesized that RTEC might be the dominant target of IL-17 activity in the infected kidney...
May 3, 2018: JCI Insight
https://www.readbyqxmd.com/read/29696352/-allergic-emergencies
#7
REVIEW
A-C Herr, T Biedermann, K Brockow
Both anaphylactic reactions and angioedema in the head and neck area can be life-threatening and require emergency treatment. Therapy needed is primarily directed by the patient's symptoms. The first measures taken should consist of immediate disruption of the allergen contact, adequate positioning of the patient, the insertion of an intravenous catheter and an emergency call. In case of cardiovascular or respiratory involvement, intramuscular ± inhalative adrenalin is the treatment of choice. In case of cardiovascular involvement, volume substitution by intravenous catheter and oxygen administration are crucial and in lower airway obstruction, additionally short-acting beta mimetics should be inhaled...
April 25, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29686743/antinociceptive-activity-of-methanolic-extract-of-clinacanthus-nutans-leaves-possible-mechanisms-of-action-involved
#8
Zainul Amiruddin Zakaria, Mohammad Hafiz Abdul Rahim, Rushduddin Al Jufri Roosli, Mohd Hijaz Mohd Sani, Maizatul Hasyima Omar, Siti Farah Mohd Tohid, Fezah Othman, Siew Mooi Ching, Arifah Abdul Kadir
Methanolic extract of Clinacanthus nutans Lindau leaves (MECN) has been proven to possess antinociceptive activity that works via the opioid and NO-dependent/cGMP-independent pathways. In the present study, we aimed to further determine the possible mechanisms of antinociception of MECN using various nociceptive assays. The antinociceptive activity of MECN was (i) tested against capsaicin-, glutamate-, phorbol 12-myristate 13-acetate-, bradykinin-induced nociception model; (ii) prechallenged against selective antagonist of opioid receptor subtypes ( β -funaltrexamine, naltrindole, and nor-binaltorphimine); (iii) prechallenged against antagonist of nonopioid systems, namely, α 2 -noradrenergic (yohimbine), β -adrenergic (pindolol), adenosinergic (caffeine), dopaminergic (haloperidol), and cholinergic (atropine) receptors; (iv) prechallenged with inhibitors of various potassium channels (glibenclamide, apamin, charybdotoxin, and tetraethylammonium chloride)...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29673745/-acquired-c1-esterase-inhibitor-deficiency-via-bradykinin-mediated-angioedema-four-cases
#9
C Jacquin-Porretaz, F Castelain, E Daguindau, E Seilles, C Nardin, F Aubin, F Pelletier
BACKGROUND: Acquired C1-esterase inhibitor (C1-INH) deficiency angioedema (C1-INH-AAE) is a form of bradykinin-mediated angioedema. This rare disorder is due to acquired consumption of C1-INH, hyperactivation of the classic pathway of human complement, and potentially fatal recurrent angioedema symptoms. Clinical symptoms of C1-INH-AAE are very similar to those of hereditary angioedema (HAE) but usually appear after the fourth decade of life and induce abdominal pain less frequently. Laboratory tests are essential in establishing the diagnosis with low levels or abnormal structure and function of C1-INH...
April 16, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29620606/apelin-reduces-nitric-oxide-induced-relaxation-of-cerebral-arteries-by-inhibiting-activation-of-large-conductance-calcium-activated-k-channels
#10
Amreen Mughal, Chengwen Sun, Stephen T OʼRourke
Activation of the apelin/APJ receptor signaling system causes endothelium-dependent and nitric oxide (NO)-dependent relaxation in several peripheral arteries. The effects of apelin in cerebral arteries are unknown; however, apelin inhibits voltage-dependent increases in large-conductance, calcium-activated K channel (BKCa) currents in cerebral artery smooth muscle cells. Because NO-induced relaxation of cerebral arteries is mediated, in part, by activation of BKCa channels, the goals of this study were to determine the net effect of apelin in cerebral arteries, as well as test the hypothesis that the actions of apelin in cerebral arteries are secondary to stimulation of APJ receptors...
April 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29619369/cell-receptor-and-cofactor-interactions-of-the-contact-activation-system-and-factor-xi
#11
REVIEW
Monika Pathak, Bubacarr Gibril Kaira, Alexandre Slater, Jonas Emsley
The contact activation system (CAS) or contact pathway is central to the crosstalk between coagulation and inflammation and contributes to diverse disorders affecting the cardiovascular system. CAS initiation contributes to thrombosis but is not required for hemostasis and can trigger plasma coagulation via the intrinsic pathway [through factor XI (FXI)] and inflammation via bradykinin release. Activation of factor XII (FXII) is the principal starting point for the cascade of proteolytic cleavages involving FXI, prekallikrein (PK), and cofactor high molecular weight kininogen (HK) but the precise location and cell receptor interactions controlling these reactions remains unclear...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29618333/the-kallikrein-kinin-system-modulates-the-progression-of-colorectal-liver-metastases-in-a-mouse-model
#12
Patricia Luiza Nunes da Costa, David Wynne, Theodora Fifis, Linh Nguyen, Marcos Perini, Christopher Christophi
BACKGROUND: The Kallikrein-Kinin System (KKS) has been found to play a role in tumor progression in several cancers. The KKS metabolic cascade depends on signalling through two cross talking receptors; bradykinin receptor 1 (B1R) and bradykinin receptor 2 (B2R). Activation of the Kinin receptor is responsible for multiple pathophysiologic functions including increase of vascular permeability and induction of host inflammatory responses that exert diverse effects on tumor growth. METHODS: B1R and B2R expression on mouse and human CRC cell lines was investigated...
April 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29615639/trpm7-in-chbp-induced-renoprotection-upon-ischemia-reperfusion-related-injury
#13
Aifen Liu, Jing Wu, Cheng Yang, Yuanyuan Wu, Yufang Zhang, Fengbo Zhao, Hui Wang, Li Yuan, Lirui Song, Tongyu Zhu, Yaping Fan, Bin Yang
Transient receptor potential melastatin 7 (TRPM7) is a membrane ion channel and kinase. TRPM7 was abundantly expressed in the kidney, and up-regulated by ischemia reperfusion (IR) injury. Our previous studies showed that cyclic helix B peptide (CHBP) improved renal IR-related injury, but its underlying mechanism is not well defined. IR-related injury was established in renal tubular epithelial cells (TCMK-1 and HK-2) via 12 to 24-h hypoxia (H) followed by 2-24 h reoxygenation (R), and in mouse kidneys subjected to 30-min ischemia and 12-h to 7-day reperfusion...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29604964/selective-inhibition-of-histamine-evoked-ca-2-signals-by-compartmentalized-camp-in-human-bronchial-airway-smooth-muscle-cells
#14
Philippa Dale, Victoria Head, Mark R Dowling, Colin W Taylor
Intracellular Ca2+ and cAMP typically cause opposing effects on airway smooth muscle contraction. Receptors that stimulate these pathways are therapeutic targets in asthma and chronic obstructive pulmonary disease. However, the interactions between different G protein-coupled receptors (GPCRs) that evoke cAMP and Ca2+ signals in human bronchial airway smooth muscle cells (hBASMCs) are poorly understood. We measured Ca2+ signals in cultures of fluo-4-loaded hBASMCs alongside measurements of intracellular cAMP using mass spectrometry or [3 H]-adenine labeling...
May 2018: Cell Calcium
https://www.readbyqxmd.com/read/29599966/effectiveness-of-icatibant-for-treatment-of-hereditary-angioedema-attacks-is-not-affected-by-body-weight-findings-from-the-icatibant-outcome-survey-a-cohort-observational-study
#15
Teresa Caballero, Andrea Zanichelli, Werner Aberer, Marcus Maurer, Hilary J Longhurst, Laurence Bouillet, Irmgard Andresen
Background: Icatibant is a bradykinin B2-receptor antagonist used for the treatment of hereditary angioedema attacks resulting from C1-inhibitor deficiency. Treatment is not adjusted by body weight however the impact of body mass index (BMI) on the effectiveness of icatibant is not documented in the literature. We examined disease characteristics and icatibant treatment effectiveness in patients stratified by BMI in the Icatibant Outcome Survey, an ongoing, international, observational study monitoring the real-world safety and effectiveness of icatibant...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29579546/role-of-selective-blocking-of-bradykinin-b1-receptor-in-attenuating-immune-liver-injury-in-trichloroethylene-sensitized-mice
#16
Jiaxiang Zhang, Na Li, Ling Yang, Dandan Zang, Peng Yang, Hui Wang, Tong Shen, Qi-Xing Zhu
Trichloroethylene (TCE) is able to induce trichloroethylene hypersensitivity syndrome (THS) with multi-system immune injuries. In our previous study, we found kallikrein-kinin system (KKS) activation, including the bradykinin B1 receptor (B1R), which contributed to immune organ injury in TCE sensitized mice. However, the mechanism of B1R mediating immune dysfunction is not clarified. The present study initiates to investigate the potential mechanism of B1R on liver injury. We establish a TCE sensitized BALB/c mouse model to explore the mechanism with or without a B1R inhibitor R715...
March 23, 2018: Cytokine
https://www.readbyqxmd.com/read/29574744/peptidoglycan-induces-bradykinin-receptor-1-expression-through-toll-like-receptor-2-and-nf-%C3%AE%C2%BAb-signaling-pathway-in-human-nasal-mucosa-derived-fibroblasts-of-chronic-rhinosinusitis-patients
#17
Yih-Jeng Tsai, Jessie Chao-Yun Chi, Chung-Yu Hao, Wen-Bin Wu
Numerous studies have demonstrated that Gram-positive microbiomes play an important role in the pathogenesis and in the way of treatment of chronic rhinosinusitis (CRS). Kinins are inflammatory mediators and one of their receptors, namely bradykinin receptor 1 (BKR1 or B1R), is believed to be induced and involved in inflammation in pathophysiological conditions. In the present study, we investigated the effect of peptidoglycan (PGN), a major cell wall component of G(+) bacteria, on BKR expression and its signaling pathway in nasal fibroblasts from CRS without nasal polyp (CRSsNP)...
March 25, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29559112/effect-of-the-bradykinin-1-receptor-antagonist-ssr240612-after-oral-administration-in-mycobacterium-tuberculosis-infected-mice
#18
Valnês S Rodrigues-Junior, Priscilla B Pail, Anne D Villela, Virgínia C A Falcão, Adílio S Dadda, Bruno L Abbadi, João B Pesquero, Diógenes S Santos, Luiz A Basso, Maria M Campos
The role, if any, played by the kinin system in tuberculosis infection models, either in vivo or in vitro, was investigated. The effects of Mycobacterium tuberculosis infection on C57BL/6 wild type, B1 R-/-, B2 R-/- and double B1 R/B2 R knockout mice were evaluated. Immunohistochemistry analysis was carried out to assess B1 R and B2 R expression in spleens and lungs of M. tuberculosis-infected mice. In addition, in vitro experiments with M. tuberculosis-infected macrophages were performed. The in vivo effects of HOE-140 and SSR240612 on the mice model of infection were also evaluated...
March 2018: Tuberculosis
https://www.readbyqxmd.com/read/29557886/multiple-inhibitory-mechanisms-of-lidocaine-on-bradykinin-receptor-activity-in-model-sensory-neurons
#19
Chika Hamaya, Travis Barr, Gary R Strichartz
BACKGROUND AND OBJECTIVES: Local anesthetics (LAs) are often infiltrated subcutaneously for localized perioperative numbing. In addition to blocking nerve conduction, LAs act on pathways used by a variety of pain-inducing and inflammatory mediators. We describe the effects in isolated model sensory neurons of LAs on responses to the algogenic and sensitizing peptide, bradykinin (BK). METHODS: ND/7 sensory neurons were stimulated by different concentrations of BK in the presence or absence of LAs, with transient increases in intracellular calcium (Δ[Ca]in) detected fluorometrically in fields of cells...
March 17, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29553114/-efficacy-pharmacokinetics-and-safety-of-icatibant-for-the-treatment-of-japanese-patients-with-an-acute-attack-of-hereditary-angioedema-a-phase-3-open-label-study
#20
Michihiro Hide, Atsushi Fukunaga, Junichi Maehara, Kazunori Eto, James Hao, Moshe Vardi, Yuji Nomoto
BACKGROUND: Hereditary angioedema (HAE) is characterized by paroxysmal edema of the skin, gastrointestinal mucosa, and upper respiratory tract. PURPOSE: This study investigated icatibant, a selective bradykinin B2 receptor antagonist, as treatment for Japanese patients with an acute HAE attack. METHODS: This was an open-label, single-arm, Phase 3 study of Japanese adults with HAE type I or II. Icatibant (30 mg) was administered (by a healthcare professional [HCP] or self-administered) as a subcutaneous injection in the abdomen...
2018: Arerugī, [Allergy]
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