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meibomian gland dysfunction

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https://www.readbyqxmd.com/read/29150990/prevalence-of-dry-eye-disease-and-its-association-with-dyslipidemia
#1
Krishnamoorthy Rathnakumar, Kaliaperumal Ramachandran, Durairaj Baba, Venkatachalam Ramesh, Velusamy Anebaracy, Ramachandran Vidhya, Rajamanickam Vinothkumar, Ramamurthy Poovitha, Rajagopalan Geetha
BACKGROUND: Dry eye disease (DED) is a common ocular surface disease significantly affecting the quality of life of patients. The aim of our study is to focus on the prevalence of DED and to determine the relationship between dyslipidemia and DED. METHODS: The study was performed with the age group of 25-70 years, who attended the ophthalmology outpatient department at Sri Lakshmi Narayana Institute of Medical Sciences with complaints of dry eye. A standard questionnaire was taken, and tear film tests were performed to diagnose dry eye...
November 18, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29135567/benign-reactive-lymphoid-hyperplasia-of-the-conjunctiva-treated-with-cyclosporine
#2
Rupin N Parikh, Harpal S Sandhu, Giacomina Massaro-Giordano, Scott M Goldstein, Joan M OʼBrien
PURPOSE: To describe a case of reactive lymphoid hyperplasia (RLH) of the conjunctiva responding to cyclosporine immunosuppressant monotherapy. METHODS: A 66-year-old man with a 2-year history of biopsy-proven bilateral RLH presented for dry eye evaluation with chief complaints of burning, stinging, and irritation in both eyes. After slit-lamp examination and positive findings of matrix metalloproteinase 9 in the patient's tear film, he was diagnosed with meibomian gland dysfunction and tear-insufficiency dry eye disease...
November 10, 2017: Cornea
https://www.readbyqxmd.com/read/29134276/-novel-current-and-future-therapy-options-for-treatment-of-dry-eye-disease
#3
REVIEW
E M Messmer
Dry eye disease was redefined by the dry eye workshop (DEWS II) in May 2017. According to the new definition "dry eye is a multifactorial disease of the ocular surface characterized by a loss of homeostasis of the tear film and accompanied by ocular symptoms". The current definition encompasses etiological factors, such as instability and hyperosmolarity of the tear film, ocular surface inflammation and damage as well as a new aspect compared to the former definition, neurosensory abnormalities. Recent and future therapeutic options for dry eye focus on treatment of the aforementioned pathogenetic events...
November 13, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29107074/loss-of-%C3%AE-epithelial-sodium-channel-function-in-meibomian-glands-produces-pseudohypoaldosteronism-1-like-ocular-disease-in-mice
#4
Dongfang Yu, Yogesh Saini, Gang Chen, Andrew J Ghio, Hong Dang, Kimberlie A Burns, Yang Wang, Richard M Davis, Scott H Randell, Charles R Esther, Friedrich Paulsen, Richard C Boucher
Human subjects with pseudohypoaldosteronism-1 due to loss of function mutations in epithelial Na(+) channel (ENaC) subunits exhibit meibomian gland (MG) dysfunction. A conditional βENaC MG knockout mouse model was generated to elucidate the pathogenesis of absent ENaC function in the MG and associated ocular surface disease. βENaC MG KO mice exhibited a striking age dependent, female predominant MG dysfunction phenotype, with white toothpaste-like secretions observed obstructing MG orifices at seven weeks of age...
October 26, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29075094/effect-of-topical-3-diquafosol-sodium-on-eyes-with-dry-eye-disease-and-meibomian-gland-dysfunction
#5
Shiro Amano, Kenji Inoue
PURPOSE: To prospectively evaluate the effect of topical diquafosol sodium on eyes with dry eye disease (DED) and meibomian gland dysfunction (MGD). PATIENTS AND METHODS: The subjects were consecutive patients diagnosed with both DED and MGD at Inouye Eye Hospital between March and September of 2016. The subjects were administered topical 3% diquafosol sodium ophthalmic solution six times a day for 3 months. At each study visit, subjects underwent slit-lamp examination and completed MGD symptoms and dry eye-related quality of life score (DEQS) questionnaires...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29071272/conjunctival-blue-naevus-in-an-anophthalmic-socket
#6
Hibba Quhill, Paul A Rundle, Hardeep Singh Mudhar
PURPOSE OF THE STUDY: To describe an unusual brown pigmented lesion of the conjunctiva in an anophthalmic socket in a 16-year-old male. PROCEDURES: A 16-year-old male patient presented with socket irritation whilst wearing an artificial eye due to meibomian gland dysfunction. An area of flat, subepithelial, dark brown pigmentation with irregular and indistinct borders on the bulbar conjunctiva of the anophthalmic socket was seen. The patient believed it had been present for at least 2 years...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29055903/significant-correlation-between-meibomian-gland-dysfunction-and-keratitis-in-young-patients-with-demodex-brevis-infestation
#7
Lingyi Liang, Yan Liu, Xiaohu Ding, Hongmin Ke, Chuan Chen, Scheffer C G Tseng
AIMS: To report the clinical characteristics and correlation between meibomian gland dysfunction (MGD) and keratitis in young patients with ocular demodicosis. METHODS: Observational case series of 60 patients younger than 35 years with ocular demodicosis, of which the diagnosis was based on microscopic counting of Demodex folliculorum and D. brevis of epilated lashes. Severity of keratitis and MGD was graded by photography and meibography, respectively, in a masked fashion...
October 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29055358/meibomian-gland-disease-the-role-of-gland-dysfunction-in-dry-eye-disease
#8
REVIEW
Priyanka Chhadva, Raquel Goldhardt, Anat Galor
TOPIC: To discuss the pathology, causes, and ocular surface impact of meibomian gland disease (MGD), as well as its relationship to dry eye. CLINICAL RELEVANCE: MGD is a common disorder with various contributing mechanisms and clinical manifestations. Understanding MGD pathophysiology and its relationship to dry eye is important in order to optimize diagnosis and treatment algorithms. METHODS: A review of current literature was performed to discern MGD in terms of pathophysiology, risk factors, and ocular surface impact, and the relationship to dry eye...
November 2017: Ophthalmology
https://www.readbyqxmd.com/read/29052604/effect-of-topical-loteprednol-etabonate-with-lid-hygiene-on-tear-cytokines-and-meibomian-gland-dysfunction-in-prosthetic-eye-wearers
#9
J S Ko, Y Seo, M K Chae, S Y Jang, J S Yoon
PurposeTo assess tear cytokine levels and clinical outcomes in meibomian gland dysfunction (MGD) in the blind eye of patients wearing an ocular prosthesis after 2 months of treatment with topical loteprednol etabonate and eyelid scrubs with warm compresses.Patients and methodsThis study included patients with MGD wearing a unilateral ocular prosthesis for more than 1 year. All patients topically received 0.5% loteprednol etabonate and were instructed to scrub their eyelids with warm compresses on the prosthetic eye for 2 months...
October 20, 2017: Eye
https://www.readbyqxmd.com/read/29033270/a-survey-of-contact-lens-related-complications-in-a-tertiary-hospital-in-china
#10
Weiwei Li, Xuguang Sun, Zhiqun Wang, Yang Zhang
PURPOSE: To describe the type of complications related to contact lens (CL) wear in a tertiary hospital in XX, China. METHODS: A retrospective study of 141 patients who complained discomfort after wearing contact lens on an outpatient basis of XX Hospital were conducted from the January 2012 to December 2015. The data included patients' demographics, lens type, history, slit-lamp examination, reports of corneal scrapings, culture, and examination of in vivo confocal microscopy...
October 12, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28974425/comparison-of-treatment-effect-across-varying-severities-of-meibomian-gland-dropout
#11
Philip R K Turnbull, Stuti L Misra, Jennifer P Craig
PURPOSE: Better understanding of the pathophysiology of meibomian gland dysfunction (MGD) has provided the opportunity to develop treatments which could be tailored for specific presentations of MGD. This study sought to directly compare treatment effectiveness for three current therapies across differing levels of MG dropout. METHODS: Subjects (n=81), grouped by infrared meibography dropout proportions, into either no (control), mild, or pronounced MG dropout, were randomised to receive treatment with a latent heat device (n=25), liposomal spray (n=28), or heated warm compress (n=28)...
September 30, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28958587/investigation-of-antioxidant-systems-in-human-meibomian-gland-and-conjunctival-tissues
#12
Hachemi Nezzar, Joyce N Mbekeani, Anais Noblanc, Frédéric Chiambaretta, Joël R Drevet, Ayhan Kocer
Oxidative stress (OS) associated with direct contact with the environment and light exposure is a very potent and continuous stressor of the ocular surface and internal structures of the eye that are required to manage its effects. Constant replenishment of tears together with the superficial lipid layer produced by the meibomian glands (MG) is one protective mechanism. The lipid-rich fraction of the tears coats the deeper aqueous fraction, preventing its evaporation. However, lipids are particularly sensitive to oxidative damage that could alter tear film quality...
September 27, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28957980/functional-morphology-of-the-lipid-layer-of-the-tear-film
#13
Reiko Arita, Shima Fukuoka, Naoyuki Morishige
Meibomian glands secrete the oily layer of the tear film, which prevents excessive evaporation of tear fluid. Dysfunction of meibomian glands is not only one of the causes of evaporative dry eye but also one of the main causes of entire dry eye. To understand the pathophysiology of meibomian gland dysfunction, it is important to evaluate both the morphology and function of the meibomian gland. We previously reported that meibography enabled visualization of the morphology of the meibomian gland. Meanwhile, tear interferometry was introduced as an evaluation method for the function of the meibomian gland...
November 2017: Cornea
https://www.readbyqxmd.com/read/28950941/ocular-surface-inflammation-impairs-structure-and-function-of-meibomian-gland
#14
REVIEW
Shin Mizoguchi, Hiroki Iwanishi, Reiko Arita, Kumi Shirai, Takayoshi Sumioka, Masahide Kokado, James V Jester, Shizuya Saika
Dysfunction of the meibomian glands alters secreted meibum quantitatively and qualitatively that can lead to damage to the ocular surface epithelium. In response to an unstable tear film cause by meibomian gland dysfunction, ocular surface epithelium is damaged and expresses inflammatory cytokines leading to secondary ocular inflammation. In turn, inflammatory disorders of the palpebral conjunctiva and lid margin may affect the structure and function of meibomian gland. The disorders include allergic conjunctivitis, long-term usage of contact lenses, dermatological diseases that affect conjunctival homeostasis, Stevens-Johnson's syndrome or chemical burning of the ocular surface and lid margin...
October 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28950940/morphological-evaluation-for-diagnosis-of-dry-eye-related-to-meibomian-gland-dysfunction
#15
REVIEW
Young-Sik Yoo, Kyung-Sun Na, Dae Yu Kim, Suk-Woo Yang, Choun-Ki Joo
The evaluation of morphological changes of the acini in the meibomian glands is important for the diagnosis and management of dry eye related to meibomian gland dysfunction. While several tools have been developed to detect meibomian gland structure, infrared imaging is generally used in clinical settings. Unlike the lipid component analysis of tear film in which quantitative analysis is possible, the meibomian glands are limited to qualitative analysis because of the low image quality of the diagnostic tools...
October 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28950939/new-insights-into-the-morphology-and-function-of-meibomian-glands
#16
REVIEW
Reiko Arita, Shima Fukuoka, Naoyuki Morishige
Meibomian glands secrete meibum, which gives rise to the lipid layer of the tear film and thereby prevents excessive evaporation of tear fluid. Meibomian gland dysfunction (MGD) is a major causative condition of evaporative dry eye, which is more common than the aqueous-deficient type of dry eye. Noninvasive meibography relies on infrared light and an infrared-sensitive camera to reveal the morphology of meibomian glands in both the upper and lower eyelids, whereas tear interferometry allows both qualitative and quantitative evaluation of the lipid layer of the tear film...
October 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28950937/function-of-meibomian-gland-contribution-of-proteins
#17
REVIEW
M Vimalin Jeyalatha, Yangluowa Qu, Zhen Liu, Shangkun Ou, Xin He, Jinghua Bu, Sanming Li, Peter Sol Reinach, Zuguo Liu, Wei Li
The meibomian gland is the major contributor to the tear film lipid layer. It is generally accepted that meibomian gland secretions, i.e, meibum, play a critical role in the homeostasis of the tear film. Lipid components of meibum and their structure, as well as functions were intensively studied. However, the proteins from meibum have not attracted enough attention. This review summarizes current knowledge about protein components of the meibum, particularly their function on tear film and ocular surface, and changes in the proteins during meibomian gland dysfunction (MGD)...
October 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28950936/structure-function-relationship-of-tear-film-lipid-layer-a%C3%A2-contemporary-perspective
#18
REVIEW
Georgi As Georgiev, Petar Eftimov, Norihiko Yokoi
Tear film lipid layer (TFLL) stabilizes the air/tear surface of the human eye. Meibomian gland dysfunction (MGD) resulting in quantitative and qualitative modifications of TFLL major (>93%) component, the oily secretion of meibomian lipids (MGS), is the world leading cause of dry eye syndrome (DES) with up to 86% of all DES patients showing signs of MGD. Caused by intrinsic factors (aging, ocular and general diseases) and by extrinsic everyday influences like contact lens wear and extended periods in front of a computer screen, DES (resulting in TF instability, visual disturbances and chronic ocular discomfort) is the major ophthalmic public health disease of the present time affecting the quality of life of 10-30% of the human population worldwide...
October 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28939264/the-effects-of-a-hydrating-mask-compared-to-traditional-warm-compresses-on-tear-film-properties-in-meibomian-gland-dysfunction
#19
Jacqueline Tan, Lily Ho, Katherine Wong, Alma La, Sylbi Lee, Sarah Park, Larissa Tran, Fiona Stapleton
No abstract text is available yet for this article.
September 19, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28926885/-evaluation-of-short-term-effect-of-intense-pulsed-light-combined-with-meibomian-gland-expression-in-the-treatment-of-meibomian-gland-dysfunction
#20
B Rong, P Tu, Y Tang, R X Liu, W J Song, X M Yan
Objective: To explore short-term effect of intense pulsed light (IPL) combined with meibomian gland expression in treating meibomian gland dysfunction (MGD). Methods: This study was a prospective, randomized, double-masked, controlled study. Forty-four MGD patients were enrolled in the study and received three consecutive IPL treatments with an interval of 4 weeks. One eye of each patient was randomly assigned as the study eye receiving the IPL therapy with an energy of 14-16 J/cm(2), and the fellow eye was as the control eye receiving a placebo therapy with 0 J/cm(2)...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
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