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meibomian gland dysfunction

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https://www.readbyqxmd.com/read/28790801/intense-pulsed-light-for-evaporative-dry-eye-disease
#1
REVIEW
Steven J Dell
There is a clear association between dry eye disease (DED) and skin inflammatory diseases occurring in close proximity to the eyelids, such as facial skin rosacea. Intense pulsed light (IPL) is widely accepted as a treatment for skin rosacea. A number of recent studies demonstrated that, in patients suffering from meibomian gland dysfunction (MGD), IPL therapy also reduces signs and symptoms of DED. Despite these encouraging results, in the context of DED and MGD, the mechanisms of action of IPL are not well understood...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28739099/changes-of-meibomian-glands-in-the-early-stage-of-post-hematopoietic-stem-cell-transplantation
#2
Seonjoo Kim, Young-Sik Yoo, Hyun Seung Kim, Choun-Ki Joo, Kyung-Sun Na
Hematopoietic stem cell transplantation (HSCT) is the most effective cure for hematologic malignancies. Graft-versus-host disease (GVHD) is a major complication following allogeneic HSCT, which significantly affects non-relapse mortality. And ocular manifestations of GVHD are known to occurin 60-90% of patients with chronic GVHD. Although the pathogenesis of ocular GVHD is not clearly known, it is known to progress into inflammation and fibrosis through presentation of antigens on CD4 and CD8 T cells. There is much evidence that the ocular surface and meibomian glands are severely damaged in ocular GVHD patients, and there are few observational studies on the early changes...
July 21, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28736342/tfos-dews-ii-diagnostic-methodology-report
#3
REVIEW
James S Wolffsohn, Reiko Arita, Robin Chalmers, Ali Djalilian, Murat Dogru, Kathy Dumbleton, Preeya Gupta, Paul Karpecki, Sihem Lazreg, Heiko Pult, Benjamin D Sullivan, Alan Tomlinson, Louis Tong, Edoardo Villani, Kyung Chul Yoon, Lyndon Jones, Jennifer Craig
The role of the Tear Film and Ocular Surface Society (TFOS) Dry Eye Workshop (DEWS) II Diagnostic Methodology Subcommittee was 1) to identify tests used to diagnose and monitor dry eye disease (DED), 2) to identify those most appropriate to fulfil the definition of DED and its sub-classifications, 3) to propose the most appropriate order and technique to conduct these tests in a clinical setting, and 4) to provide a differential diagnosis for DED and distinguish conditions where it is a comorbidity. Symptom screening with the DEQ-5 or OSDI confirms that a patient might have DED and triggers the diagnostic tests of (ideally non-invasive) breakup time, osmolarity and ocular surface staining with fluorescein and lissamine green (observing the cornea, conjunctiva and eyelid margin)...
May 4, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28694455/asymptomatic-meibomian-gland-dysfunction-and-cardiovascular-disease-risk-factors-in-a-middle-aged-population-in-taiwan-a-cross-sectional-analysis
#4
Alexander Chen, Hung-Ta Chen, Hung-Chi Chen, Yi-Tsun Chen, Yih-Hsiou Hwang, Chi-Chin Sun, Ching-Hsi Hsiao, David Hui-Kang Ma, Wei-Chi Wu, Chi-Chun Lai
Managing cardiovascular disease (CVD) risk factors is the key to prevent CVD. This study aimed to prevent CVD by introducing asymptomatic meibomian gland dysfunction (MGD), a condition associated with various CVD risk factors, as an early indicator for CVD in middle-aged population. Participants with and without asymptomatic MGD underwent standardized questionnaires, physical examinations, and laboratory investigations. One ophthalmologist completed the identification and grading of MGD by using slit-lamp biomicroscopy examination on the eyelid margins, meibomian gland orifices, and meibomian gland secretions...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28689165/tear-film-and-ocular-surface-assessment-in-psoriasis
#5
Emanuela Aragona, Laura Rania, Elisa Imelde Postorino, Alberto Interdonato, Roberta Giuffrida, Serafinella Patrizia Cannavò, Domenico Puzzolo, Pasquale Aragona
BACKGROUND: Psoriasis is a skin disease with also systemic involvement: its impact on the eye is not well established and often clinically underestimated. Aim of this study was to investigate the presence of ocular discomfort symptoms and of ocular surface changes in a population of patients with psoriasis. METHODS: For this cross-sectional, comparative study, 66 patients with psoriasis were subdivided according to the presence of arthritis and to the use of biological therapy...
July 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28688025/dyslipidemia-and-its-association-with-meibomian-gland-dysfunction-a-systematic-review
#6
REVIEW
Robin K Kuriakose, Puneet S Braich
PURPOSE: To perform a systematic review of the literature examining the association between meibomian gland dysfunction (MGD) and dyslipidemia. METHODS: A systematic literature search was performed using the Medline database. A total of four studies directly relevant to our search are reviewed here. RESULTS: In a series of four studies, all but one found that the prevalence of dyslipidemia was significantly higher in those with MGD compared to those without...
July 7, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28677153/assessment-of-efficacy-of-topical-azithromycin-1-5-per-cent-ophthalmic-solution-for-the-treatment-of-meibomian-gland-dysfunction
#7
Ozlem Balci, Gokhan Gulkilik
BACKGROUND: The aim was to evaluate the clinical efficacy of topical azithromycin 1.5 per cent ophthalmic solution in treatment of the clinical signs and symptoms associated with meibomian gland dysfunction (MGD). METHODS: In this retrospective study, 35 patients with MGD were treated with topical azithromycin 1.5 per cent ophthalmic solution for 30 days. Topical azithromycin 1.5 per cent ophthalmic solution was prescribed twice daily for two days and then once daily for a total of 30 days...
July 4, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28646862/a-clinical-utility-assessment-of-the-automatic-measurement-method-of-the-quality-of-meibomian-glands
#8
Robert Koprowski, Lei Tian, Paweł Olczyk
BACKGROUND: Meibomian gland dysfunction (MGD) is one of the most common diseases observed in clinics and is the leading cause of evaporative dry eye. Today, diagnostics of MGD is not fully automatic yet and is based on a qualitative assessment made by an ophthalmologist. Therefore, an automatic analysis method was developed to assess MGD quantiatively. MATERIALS: The analysis made use of 228 images of 57 patients recorded by OCULUS Keratograph(®) 5 M with a resolution of 1024 × 1360 pixels concern 30 eyes of healthy individuals (14 women and 16 men) and 27 eyes of sick patients (10 women and 17 men)...
June 24, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28645677/dry-eye-and-meibomian-gland-dysfunction-with-meibography-in-patients-with-lamellar-ichthyosis
#9
Melis Palamar, Irmak Karaca, Huseyin Onay, Ilgen Ertam, Ayse Yagci
PURPOSE: To evaluate the dry eye findings and Meibomian gland dysfunction as demonstrated with meibography in patients with lamellar ichthyosis. METHODS: Twenty-four eyes of 12 patients with lamellar ichthyosis (Group 1) and twenty-four eyes of 12 healthy individuals (Group 2) were enrolled. Comprehensive eye examination along with corneal and conjunctival fluorescein staining with Oxford scoring, tear film break-up time, Schirmer 1 test, ocular surface disease index (OSDI) score assessment, and evaluation of upper and lower eyelid Meibomian glands using infrared filter of slit-lamp biomicroscope (SL-D701, TOPCON, Tokyo, Japan) were performed...
June 20, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28598963/response-to-the-association-of-chronic-topical-prostaglandin-analog-use-with-meibomian-gland-dysfunction-comment
#10
Mehmet C Mocan, Enes Uzunosmanoglu, Sibel Kocabeyoglu, Jale Karakaya, Murat Irkec
No abstract text is available yet for this article.
June 8, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28593054/meibomian-gland-dysfunction-in-type-2-diabetic-patients
#11
Xiaolei Lin, Binbin Xu, Yuxi Zheng, Terry G Coursey, Yinying Zhao, Junhua Li, Yana Fu, Xuewen Chen, Yun-E Zhao
PURPOSE: To investigate meibomian gland and tear film function in patients with type 2 diabetes. METHODS: This prospective study compared changes in meibomian gland and tear film function in type 2 diabetic patients with nondiabetic patients. Meibomian gland function was evaluated by measuring lipid layer thickness (LLT), grading of meibomian gland loss, lid margin abnormalities, and expression of meibum. Tear film function was assessed by measuring tear breakup time (TBUT), the Schirmer I test, noninvasive breakup time (NIBUT), tear meniscus height (TMH), and corneal fluorescein staining...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28592418/growth-of-meibomian-gland-tissue-after-intraductal-meibomian-gland-probing-in-patients-with-obstructive-meibomian-gland-dysfunction
#12
Steven L Maskin, Whitney R Testa
PURPOSE: To investigate the impact of meibomian gland probing (MGP) on meibomian gland (MG) area from the upper lids of patients with obstructive meibomian gland dysfunction (o-MGD). METHODS: Retrospective study comparing pre-MGP/post-MGP non-contact infrared meibography results in patients with o-MGD, viewing signs of MG growth within total measurement field. RESULTS: Post-MGP meibography of 34 lids (19 patients, ≥4.5 to ≤12 months' follow-up) showed 41...
June 7, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28592257/clinical-safety-and-efficacy-of-vitamin-d3-analog-ointment-for-treatment-of-obstructive-meibomian-gland-dysfunction
#13
Reiko Arita, Motoko Kawashima, Masataka Ito, Kazuo Tsubota
BACKGROUND: Hyperkeratinization is a major cause of obstructive meibomian gland dysfunction (oMGD) and results in degenerative gland dilation and atrophy without inflammation. Ointment containing 1,25-dihydroxy-22-oxavitamin D3 (maxacalcitol), a noncalcemic analog of the active form of vitamin D3, is applied for the treatment of hyperkeratotic cutaneous conditions such as psoriasis and ichtyosis because it suppresses the proliferation and promotes the differentiation of keratinocytes through interaction with the vitamin D receptor...
June 7, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28587370/a-novel-noninvasive-ocular-surface-analyzer-for-the-assessment-of-dry-eye-with-meibomian-gland-dysfunction
#14
Yuanyuan Qi, Chen Zhang, Shaozhen Zhao, Yue Huang, Ruibo Yang
Meibomian gland dysfunction (MGD) is a major cause of dry eye, and the purpose of the present study was to evaluate the differences between dry eye patients with MGD and controls using a novel noninvasive ocular surface analyzer. A total of 33 dry eye patients with MGD and 31 controls were enrolled in the present study. Testing included administration of the Ocular Surface Disease Index (OSDI), followed by Keratogragh 5M (Oculus, Wetzlar, Germany), measurements of the noninvasive tear film break-up times (NITBUTs), the first tear film break-up point and the morphology of meibomian gland...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28585267/intense-pulsed-light-treatment-and-meibomian-gland-expression-for-moderate-to-advanced-meibomian-gland-dysfunction
#15
Julie M Albietz, Katrina L Schmid
BACKGROUND: The aim was to evaluate the efficacy of periocular intense pulsed light therapy combined with meibomian gland expression for chronic dry eye due to moderate to advanced meibomian gland dysfunction. METHODS: This single-institution, open-label prospective study involved 26 participants who received bilateral treatments using a proprietary intense pulsed light device (E > Eye, E-Swin, Paris, France) combined with therapeutic meibomian gland expression at baseline, Week 2 and Week 6...
June 6, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28585260/randomised-controlled-trial-of-topical-antibacterial-manuka-leptospermum-species-honey-for-evaporative-dry-eye-due-to-meibomian-gland-dysfunction
#16
Julie M Albietz, Katrina L Schmid
BACKGROUND: The aim was to evaluate the efficacy of standardised Manuka (Leptospermum species) antibacterial honey as adjunctive twice daily treatment to conventional therapy (warm compresses, lid massage and preservative-free lubricant), in participants with evaporative dry eye due to moderate to advanced meibomian gland dysfunction. METHODS: This prospective, open-label study involved 114 participants. After two weeks of conventional therapy participants were randomised to one of three treatment groups: Optimel Antibacterial Manuka Eye Gel (98 per cent Leptospermum species honey) plus conventional therapy (n = 37), Optimel Manuka plus Lubricant Eye Drops (16 per cent Leptospermum species honey) plus conventional therapy (n = 37) and a control (conventional therapy) (n = 40)...
June 6, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28567496/manifestation-of-meibomian-gland-dysfunction-in-patients-with-sj%C3%A3-gren-s-syndrome-non-sj%C3%A3-gren-s-dry-eye-and-non-dry-eye-controls
#17
Yeon Soo Kang, Hyo Seok Lee, Ying Li, Won Choi, Kyung Chul Yoon
PURPOSE: To evaluate the manifestation of meibomian gland dysfunction in patients with Sjögren's syndrome (SS), non-Sjögren's syndrome dry eye (non-SS) patients, and non-dry eye controls. METHODS: We recruited 31 participants with SS dry eye, 30 participants with non-SS dry eye, and 35 healthy controls without dry eye symptoms. Noninvasive tear breakup time (NITBUT) and meibomian gland dropout score (meiboscore) were measured using the Oculus Keratograph 5 M...
May 31, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28544605/assessment-of-meibomian-glands-and-tear-film-in-post-refractive-surgery-patients
#18
Ji Won Jung, Jung Yong Kim, Hee Seung Chin, Young Ju Suh, Tae-Im Kim, Kyoung Yul Seo
IMPORTANCE: Corneal refractive surgery may impact meibomian gland and tear film in post-refractive surgery patients. BACKGROUND: To compare ocular surface parameters between post-refractive surgery patients and normal controls. DESIGN: Cross-sectional single center study PARTICIPANTS: A total of 120 eyes of 120 subjects were divided into three groups: (i) 60 controls and 60 patients underwent corneal refractive surgery at least 12 months ago; (ii) 30 post-laser in-situ keratomileusis (LASIK) patients and (iii) 30 post-laser epithelial keratomileusis (LASEK)/photo-refractive keratectomy (PRK) patients...
May 22, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28533678/effect-of-thermal-pulsation-treatment-on-tear-film-parameters-in-dry-eye-disease-patients
#19
Michelle J Kim, Sandra S Stinnett, Preeya K Gupta
PURPOSE: The goal of this study was to evaluate the effect of thermal pulsation treatment on tear film parameters, specifically osmolarity and matrix metalloproteinase-9 (MMP-9), in patients with meibomian gland dysfunction (MGD) and dry eye disease (DED). METHODS: A single-center review of 189 eyes that underwent thermal pulsation treatment was performed. Data were collected on pre and posttreatment osmolarity, MMP-9, tear break-up time (TBUT), and ocular surface disease index (OSDI) score...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28524885/ocular-surface-analysis-in-hematological-patients-before-and-after-allogeneic-hematopoietic-stem-cell-transplantation-implication-for-daily-clinical-practice
#20
G Giannaccare, F Bonifazi, M Sessa, E Dan, M Arpinati, M Fresina, G Bandini, M Cavo, P Versura, E C Campos
PurposeTo evaluate ocular surface parameters before and after hematopoietic stem cell transplantation (HSCT) and to correlate them with clinical and transplant variables.MethodsThis is a retrospective analysis of data from 93 patients affected by hematological malignancies undergoing HSCT. Values from Ocular Surface Disease Index, Schirmer test, Break-up Time, ocular surface staining, and Meibomian Gland Dysfunction score obtained before HSCT and 3-6 months after were retrieved from charts. Diagnosis and staging of dry eye (DE) disease was performed according to Dry Eye WorkShop criteria...
May 19, 2017: Eye
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