keyword
MENU ▼
Read by QxMD icon Read
search

Central neuroplasticity

keyword
https://www.readbyqxmd.com/read/27908839/the-transition-of-acute-postoperative-pain-to-chronic-pain-an-integrative-overview-of-research-on-mechanisms
#1
C Richard Chapman, Charles J Vierck
The nature of the transition from acute to chronic pain still eludes explanation, but chronic pain resulting from surgery provides a natural experiment that invites both clinical epidemiological investigation and basic scientific inquiry into the mechanisms of this transition. The primary purpose of this paper is to review current knowledge and hypotheses on the transition from acute to persistent postsurgical pain, summarizing literature on clinical epidemiological studies of persistent postsurgical pain development, as well as basic neurophysiological studies targeting mechanisms in the periphery, spinal cord, and brain...
November 28, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27890578/adult-complex-regional-pain-syndrome-type-i-a-narrative-review
#2
REVIEW
Martino Bussa, Adriana Mascaro, Lorena Cuffaro, Simona Rinaldi
Complex regional pain syndrome type I (CRPS I) is a multifactorial painful disorder with a complex pathogenesis. Both peripheral and central mechanisms are involved. Acute CRPS I is considered an exaggerated inflammatory disorder but over time, because of altered function of the sympathetic nervous system, and maladaptive neuroplasticity, CRPS I evolves into a neurological disorder. This review thoroughly describes the pathophysiological aspects of CRPS I and summarizes the potential therapeutic options. The mechanisms and targets of the treatment are different in the early and late stages of the disease...
November 23, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27837170/differential-contributions-of-vasopressin-v1a-and-oxytocin-receptors-in-the-amygdala-to-pain-related-behaviors-in-rats
#3
Bryce Cragg, Guangchen Ji, Volker Neugebauer
Neuroplastic changes in the amygdala account for emotional-affective aspects of pain and involve neuropeptides such as calcitonin gene-related peptide and corticotropin-releasing factor. Another neuropeptide system, central arginine vasopressin, has been implicated in neuropsychiatric disorders, but its role in pain-related emotional expression and neuroplasticity remains to be determined. Here, we tested the hypothesis that arginine vasopressin in the amygdala contributes to pain-related emotional-affective responses, using stereotaxic applications of arginine vasopressin and antagonists for G-protein coupled vasopressin V1A and oxytocin receptors in adult male Sprague-Dawley rats...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27819338/quinolinic-acid-injection-in-mouse-medial-prefrontal-cortex-affects-reversal-learning-abilities-cortical-connectivity-and-hippocampal-synaptic-plasticity
#4
Amira Latif-Hernandez, Disha Shah, Tariq Ahmed, Adrian C Lo, Zsuzsanna Callaerts-Vegh, Annemie Van der Linden, Detlef Balschun, Rudi D'Hooge
Intracerebral injection of the excitotoxic, endogenous tryptophan metabolite, quinolinic acid (QA), constitutes a chemical model of neurodegenerative brain disease. Complementary techniques were combined to examine the consequences of QA injection into medial prefrontal cortex (mPFC) of C57BL6 mice. In accordance with the NMDAR-mediated synapto- and neurotoxic action of QA, we found an initial increase in excitability and an augmentation of hippocampal long-term potentiation, converting within two weeks into a reduction and impairment, respectively, of these processes...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27818352/exercise-combined-with-low-level-gabaa-receptor-inhibition-up-regulates-the-expression-of-neurotrophins-in-the-motor-cortex
#5
Kazuma Takahashi, Hiroshi Maejima, Gaku Ikuta, Hiroki Mani, Tadayoshi Asaka
Neurotrophins play a crucial role in neuroplasticity, neurogenesis, and neuroprotection in the central nervous system. Aerobic exercise is known to increase the expression of BDNF in the cerebral cortex. Several animal studies have evaluated the tonic inhibition of GABAergic synapses to enhance hippocampal plasticity as well as learning and memory, whereas the effects of GABAergic inhibition on plasticity in the cerebral cortex related to motor learning are not well characterized. The objective of the present study was to examine the interactive effect of low-level GABAA receptor inhibition and exercise on the expression of neurotrophins including BDNF in the murine motor cortex...
November 4, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27803816/eeg-source-imaging-guided-by-spatiotemporal-specific-fmri-toward-an-understanding-of-dynamic-cognitive-processes
#6
Thinh Nguyen, Thomas Potter, Trac Nguyen, Christof Karmonik, Robert Grossman, Yingchun Zhang
Understanding the mechanism of neuroplasticity is the first step in treating neuromuscular system impairments with cognitive rehabilitation approaches. To characterize the dynamics of the neural networks and the underlying neuroplasticity of the central motor system, neuroimaging tools with high spatial and temporal accuracy are desirable. EEG and fMRI stand among the most popular noninvasive neuroimaging modalities with complementary features, yet achieving both high spatial and temporal accuracy remains a challenge...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27766069/an-increase-in-alpha-band-frequency-in-resting-state-eeg-after-electrical-stimulation-of-the-ear-in-tinnitus-patients-a-pilot-study
#7
Marzena Mielczarek, Joanna Michalska, Katarzyna Polatyńska, Jurek Olszewski
In our clinic invasive transtympanal promontory positive DC stimulations were first used, with a success rate of 42%. However, non-invasive hydrotransmissive negative DC stimulations are now favored, with improvement being obtained in 37.8% directly after the treatment, and 51.3% in a follow up 1 month after treatment. The further improvement after 1 month may be due to neuroplastic changes at central level as a result of altered peripheral input. The aim of the study was to determine how/whether a single electrical stimulation of the ear influences cortical activity, and whether changes observed in tinnitus after electrical stimulation are associated with any changes in cortical activity recorded in EEG...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27688594/the-p1-biomarker-for-assessing-cortical-maturation-in-pediatric-hearing-loss-a-review
#8
Anu Sharma, Hannah Glick, Emily Deeves, Erin Duncan
We review evidence for a high degree of neuroplasticity of the central auditory pathways in early childhood, citing evidence of studies of the P1 and N1 cortical auditory evoked potentials in congenitally deaf children receiving cochlear implants at different ages during childhood, children with auditory neuropathy spectrum disorder and children with hearing loss and comorbid multiple disabilities. We discuss neuroplasticity, including cortico-cortical de-coupling and cross-modal re-organization that occurs in deafness...
December 2015: Otorinolaringologia
https://www.readbyqxmd.com/read/27625575/reactive-oxygen-species-physiological-and-physiopathological-effects-on-synaptic-plasticity
#9
REVIEW
Thiago Fernando Beckhauser, José Francis-Oliveira, Roberto De Pasquale
In the mammalian central nervous system, reactive oxygen species (ROS) generation is counterbalanced by antioxidant defenses. When large amounts of ROS accumulate, antioxidant mechanisms become overwhelmed and oxidative cellular stress may occur. Therefore, ROS are typically characterized as toxic molecules, oxidizing membrane lipids, changing the conformation of proteins, damaging nucleic acids, and causing deficits in synaptic plasticity. High ROS concentrations are associated with a decline in cognitive functions, as observed in some neurodegenerative disorders and age-dependent decay of neuroplasticity...
2016: Journal of Experimental Neuroscience
https://www.readbyqxmd.com/read/27616424/the-control-of-alternative-splicing-by-srsf1-in-myelinated-afferents-contributes-to-the-development-of-neuropathic-pain
#10
Richard P Hulse, Robert A R Drake, David O Bates, Lucy F Donaldson
Neuropathic pain results from neuroplasticity in nociceptive neuronal networks. Here we demonstrate that control of alternative pre-mRNA splicing, through the splice factor serine-arginine splice factor 1 (SRSF1), is integral to the processing of nociceptive information in the spinal cord. Neuropathic pain develops following a partial saphenous nerve ligation injury, at which time SRSF1 is activated in damaged myelinated primary afferent neurons, with minimal found in small diameter (IB4 positive) dorsal root ganglia neurons...
December 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27614205/transcriptome-assessment-of-the-pompe-gaa-mouse-spinal-cord-indicates-widespread-neuropathology
#11
Sara M F Turner, Darin J Falk, Barry J Byrne, David D Fuller
Pompe disease, caused by deficiency of acid alpha-glucosidase (GAA), leads to widespread glycogen accumulation and profound neuromuscular impairments. There has been controversy, however, regarding the role of central nervous system pathology in Pompe motor dysfunction. We hypothesized that absence of GAA protein causes progressive activation of neuropathological signaling, including pathways associated with cell death. To test this hypothesis, genomic data (Affymetrix Mouse Gene Array 2.0ST) from the mid-cervical spinal cord in 6- and 16-mo old Pompe (Gaa(-/-)) were evaluated (Broad Institute Molecular Signature Database), along with spinal cord histology...
September 9, 2016: Physiological Genomics
https://www.readbyqxmd.com/read/27589500/sensitive-periods-of-emotion-regulation-influences-of-parental-care-on-frontoamygdala-circuitry-and-plasticity
#12
REVIEW
Dylan G Gee
Early caregiving experiences play a central role in shaping emotional development, stress physiology, and refinement of limbic circuitry. Converging evidence across species delineates a sensitive period of heightened neuroplasticity when frontoamygdala circuitry is especially amenable to caregiver inputs early in life. During this period, parental buffering regulates emotional behaviors and stress physiology as emotion regulation circuitry continues to mature. By contrast, disorganized or poor quality caregiving has profound and lasting consequences on the maturation of frontoamygdala circuitry essential for emotion regulation, even following termination of this early life stressor (e...
September 2016: New Directions for Child and Adolescent Development
https://www.readbyqxmd.com/read/27587912/electrophysiologic-assessment-of-auditory-training-benefits-in-older-adults
#13
Samira Anderson, Kimberly Jenkins
Older adults often exhibit speech perception deficits in difficult listening environments. At present, hearing aids or cochlear implants are the main options for therapeutic remediation; however, they only address audibility and do not compensate for central processing changes that may accompany aging and hearing loss or declines in cognitive function. It is unknown whether long-term hearing aid or cochlear implant use can restore changes in central encoding of temporal and spectral components of speech or improve cognitive function...
November 2015: Seminars in Hearing
https://www.readbyqxmd.com/read/27586007/the-absence-of-5-ht4-receptors-modulates-depression-and-anxiety-like-responses-and-influences-the-response-of-fluoxetine-in-olfactory-bulbectomised-mice-adaptive-changes-in-hippocampal-neuroplasticity-markers-and-5-ht1a-autoreceptor
#14
J Amigó, A Díaz, F Pilar-Cuéllar, R Vidal, A Martín, V Compan, A Pazos, E Castro
Preclinical studies support a critical role of 5-HT4 receptors (5-HT4Rs) in depression and anxiety, but their influence in depression- and anxiety-like behaviours and the effects of antidepressants remain partly unknown. We evaluated 5-HT4R knockout (KO) mice in different anxiety and depression paradigms and mRNA expression of some neuroplasticity markers (BDNF, trkB and Arc) and the functionality of 5-HT1AR. Moreover, the implication of 5-HT4Rs in the behavioural and molecular effects of chronically administered fluoxetine was assessed in naïve and olfactory bulbectomized mice (OBX) of both genotypes...
December 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27582042/the-effects-of-graded-motor-imagery-and-its-components-on-phantom-limb-pain-and-disability-in-upper-and-lower-limb-amputees-a-systematic-review-protocol
#15
Katleho Limakatso, Lieselotte Corten, Romy Parker
BACKGROUND: Phantom limb pain (PLP) is characterized by the anatomical shifting of neighbouring somatosensory and motor areas into a deafferented cortical area of the brain contralateral to the amputated limb. It has been shown that maladaptive neuroplasticity is positively correlated to the perception of PLP in amputees. Recent studies support the use of graded motor imagery (GMI) and its component to alleviate the severity of PLP and disability. However, there is insufficient collective empirical evidence exploring the effectiveness of these treatment modalities in amputees with PLP...
2016: Systematic Reviews
https://www.readbyqxmd.com/read/27567276/cerebral-plasticity-windows-of-opportunity-in-the-developing-brain
#16
Fatima Yousif Ismail, Ali Fatemi, Michael V Johnston
BACKGROUND: Neuroplasticity refers to the inherently dynamic biological capacity of the central nervous system (CNS) to undergo maturation, change structurally and functionally in response to experience and to adapt following injury. This malleability is achieved by modulating subsets of genetic, molecular and cellular mechanisms that influence the dynamics of synaptic connections and neural circuitry formation culminating in gain or loss of behavior or function. Neuroplasticity in the healthy developing brain exhibits a heterochronus cortex-specific developmental profile and is heightened during "critical and sensitive periods" of pre and postnatal brain development that enable the construction and consolidation of experience-dependent structural and functional brain connections...
August 9, 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27547774/reversal-of-phantom-pain-and-hand-to-face-remapping-after-brachial-plexus-avulsion
#17
Jack W Tsao, Sacha B Finn, Matthew E Miller
Following left brachial plexus avulsion, a 20-year-old man had phantom limb pain and remapping of sensation from his paralyzed hand onto his face. Mirror therapy (15 min daily, 5 days/week) led immediately to good movement of the phantom limb with decreased pain. Within 2 weeks following nerve graft surgery, remapping of hand sensation onto the face disappeared along with resolution of phantom limb pain. Mirror therapy coupled with nerve grafting may relieve phantom limb pain due to brachial plexus avulsion and reverse hand-to-face remapping, suggesting that both peripheral and central mechanisms mediate development of phantom limb pain and cortical reorganization/neuroplasticity after brachial plexus avulsion...
June 2016: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/27500879/-significance-of-sleep-deprivation-in-the-development-of-local-epilepsy-from-neuroplasticity-opinion
#18
A V Vasilenko, L S Onishchenko, S A Zhivolupov, S V Lobzin, N N Zabolotsky, T V Bodrova
AIM: Learning cycle «sleep-wake» is of great theoretical and practical importance because it allows to understand the general patterns of adaptive mechanisms of human interaction with the environment (neuroplasticity), violations of which are the basis of many diseases of the CNS, including epilepsy. MATERIAL AND METHODS: Complex clinical and electroencephalographic (video-EEG monitoring with mandatory recording of sleep) study was carried out before and after prolonged sleep deprivation (for at least 1 day) of 178 patients with locally due to epilepsy (LEi)...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27499721/biosynthesis-of-glycerol-phosphate-is-associated-with-long-term-potentiation-in-hippocampal-neurons
#19
Giuseppe Martano, Luca Murru, Edoardo Moretto, Laura Gerosa, Giulia Garrone, Vittorio Krogh, Maria Passafaro
INTRODUCTION: Neurons have a very high energy requirement, and their metabolism is tightly regulated to ensure delivery of adequate substrate to sustain neuronal activity and neuroplastic changes. The mechanisms underlying the regulation of neuronal metabolism, however, are not completely clear. OBJECTIVE: The objective of this study was to investigate the central carbon metabolism in neurons, in order to identify the regulatory pathways governing neuronal anabolism and catabolism...
2016: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/27493839/pathophysiological-function-of-adamts-enzymes-on-molecular-mechanism-of-alzheimer-s-disease
#20
REVIEW
Murat Serdar Gurses, Mustafa Numan Ural, Mehmet Akif Gulec, Omer Akyol, Sumeyya Akyol
The extracellular matrix (ECM) is an environment that has various enzymes attended in regeneration and restoration processes which is very important to sustain physiological and biological functions of central nervous system (CNS). One of the participating enzyme systems in ECM turnover is matrix metalloproteinases. A disintegrin-like and metalloproteinase with thrombospondin type 1 motifs (ADAMTS) is a unique family of ECM proteases found in mammals. Components of this family may be distinguished from the ADAM (A Disintegrin and Metalloproteinase) family based on the multiple copies of thrombospondin 1-like repeats...
August 2016: Aging and Disease
keyword
keyword
50931
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"