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liver lncRNA

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https://www.readbyqxmd.com/read/29449541/long-noncoding-rna-meg3-suppresses-liver-cancer-cells-growth-through-inhibiting-%C3%AE-catenin-by-activating-pkm2-and-inactivating-pten
#1
Qidi Zheng, Zhuojia Lin, Jie Xu, Yanan Lu, Qiuyu Meng, Chen Wang, Yuxin Yang, Xiaoru Xin, Xiaonan Li, Hu Pu, Xin Gui, Tianming Li, Wujun Xiong, Dongdong Lu
Maternally expressed gene 3 (MEG3) encodes an lncRNA which is suggested to function as a tumor suppressor and has been showed to involve in a variety of cancers. Herein, our findings demonstrate that MEG3 inhibits the malignant progression of liver cancer cells in vitro and in vivo. Mechanistically, MEG3 promotes the expression and maturition of miR122 which targets PKM2. Therefore, MEG3 decreases the expression and nuclear location of PKM2 dependent on miR122. Furthermore, MEG3 also inhibits CyclinD1 and C-Myc via PKM2 in liver cancer cells...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29441951/lncrna-hulc-promotes-epithelial-and-smooth-muscle-like-differentiation-of-adipose-derived-stem-cells-by-upregulation-of-bmp9
#2
Yongwei Li, Zhengfei Shan, Bin Yang, Diandong Yang, Changping Men, Yuanshan Cui, Jitao Wu
AIMS: Adipose-derived stem cells (ADSCs), a source of mesenchymal stem cells, are able to differentiate into numerous cell lineages, including epithelial and smooth muscle cells. The use of ADSCs in tissue engineering technology has become the most promising therapeutic approach for urethral reconstruction. This study aimed to explore the effect of lncRNA highly upregulated in liver cancer (HULC) on the induction of ADSCs to differentiate into epithelial and smooth-muscle-like cells. METHODS: ADSCs were isolated from a male dog, and the expression of HULC in ADSCs was overexpressed by transfection with HULC expressing vector lentivirus...
January 2, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29431742/transcriptional-regulation-of-macrophage-cholesterol-efflux-and-atherogenesis-by-a-long-noncoding-rna
#3
Tamer Sallam, Marius Jones, Brandon J Thomas, Xiaohui Wu, Thomas Gilliland, Kevin Qian, Ascia Eskin, David Casero, Zhengyi Zhang, Jaspreet Sandhu, David Salisbury, Prashant Rajbhandari, Mete Civelek, Cynthia Hong, Ayaka Ito, Xin Liu, Bence Daniel, Aldons J Lusis, Julian Whitelegge, Laszlo Nagy, Antonio Castrillo, Stephen Smale, Peter Tontonoz
Nuclear receptors regulate gene expression in response to environmental cues, but the molecular events governing the cell type specificity of nuclear receptors remain poorly understood. Here we outline a role for a long noncoding RNA (lncRNA) in modulating the cell type-specific actions of liver X receptors (LXRs), sterol-activated nuclear receptors that regulate the expression of genes involved in cholesterol homeostasis and that have been causally linked to the pathogenesis of atherosclerosis. We identify the lncRNA MeXis as an amplifier of LXR-dependent transcription of the gene Abca1, which is critical for regulation of cholesterol efflux...
February 12, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29414510/adiponectin-as-lncrna-inhibits-adipogenesis-by-transferring-from-nucleus-to-cytoplasm-and-attenuating-adiponectin-mrna-translation
#4
Rui Cai, Yunmei Sun, Naren Qimuge, Guoqiang Wang, Yingqian Wang, Guiyan Chu, Taiyong Yu, Gongshe Yang, Weijun Pang
Adiponectin (AdipoQ) is an adipocyte-derived hormone with positive function on systemic glucose and lipid metabolism. Long noncoding RNA (lncRNA) is emerging as a vital regulator of adipogenesis. However, AdipoQ-related lncRNAs in lipid metabolism have not been explored. Here, AdipoQ antisense (AS) lncRNA was first identified, and we further found that it inhibited adipogenesis. The half-life of AdipoQ AS lncRNA was 10 h, whereas that of AdipoQ mRNA was 4 h. During adipogenic differentiation, AdipoQ AS lncRNA translocated from nucleus to cytoplasm...
January 29, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29383134/long-non-coding-rna-deep-sequencing-reveals-the-role-of-macrophage-in-liver-disorders
#5
Zhang Lin, Hao Changfu, Zhao Fengling, Guo Wei, Bao Lei, Li Yiping, Zhang Miao, Yue Zhongzheng, Zhao Youliang, Duan Shuyin, Yao Wu
Liver disorders such as hepatitis, cirrhosis and hepatocellular carcinoma are a series of the most life threatening diseases along with extensive inflammatory cellular infiltrations. Macrophage has been proved to be key regulators and initiators of inflammation, and long non-coding RNAs (lncRNAs) are recommended to play critical roles in the occurrence and development of a variety of diseases. To uncover the role of macrophage in liver disorders via lncRNA sequencing method, we first applied a lncRNA classification pipeline to identify 1247 lncRNAs represented on the Affymetrix Mouse Genome 430/430A 2...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29382920/a-systematic-analysis-highlights-multiple-long-non-coding-rnas-associated-with-cardiometabolic-disorders
#6
Mohsen Ghanbari, Marjolein J Peters, Paul S de Vries, Cindy G Boer, Jeroen G J van Rooij, Yu-Chi Lee, Vinod Kumar, André G Uitterlinden, M Arfan Ikram, Cisca Wijmenga, Jose M Ordovas, Caren E Smith, Joyce B J van Meurs, Stefan J Erkeland, Oscar H Franco, Abbas Dehghan
Genome-wide association studies (GWAS) have identified many susceptibility loci for cardiometabolic disorders. Most of the associated variants reside in non-coding regions of the genome including long non-coding RNAs (lncRNAs), which are thought to play critical roles in diverse biological processes. Here, we leveraged data from the available GWAS meta-analyses on lipid and obesity-related traits, blood pressure, type 2 diabetes, and coronary artery disease and identified 179 associated single-nucleotide polymorphisms (SNPs) in 102 lncRNAs (p-value < 2...
January 30, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29382663/long-non-coding-rna-lncshgl-recruits-hnrnpa1-to-suppress-hepatic-gluconeogenesis-and-lipogenesis
#7
Junpei Wang, Weili Yang, Zhenzhen Chen, Ji Chen, Yuhong Meng, Biaoqi Feng, Libo Sun, Lin Dou, Jian Li, Qinghua Cui, Jichun Yang
Mammalian genomes encode a huge number of LncRNAs with unknown functions. This study determined the role and mechanism of a new LncRNA, LncRNA Suppressor of Hepatic Gluconeogenesis and Lipogenesis (LncSHGL), in regulating hepatic glucose/lipid metabolism. In the livers of obese mice and NAFLD patient, the expression levels of mouse LncSHGL and its human homologous LncRNA B4GALT1-AS1 were reduced. Hepatic LncSHGL restoration improved hyperglycemia, insulin resistance and steatosis in obese diabetic mice, whereas hepatic LncSHGL inhibition promoted fasting hyperglycemia and lipid deposition in normal mice...
January 30, 2018: Diabetes
https://www.readbyqxmd.com/read/29369172/long-noncoding-rna-hypoxia-inducible-factor-1-alpha-antisense-rna-1-promotes-tumor-necrosis-factor-%C3%AE-induced-apoptosis-through-caspase-3-in-kupffer-cells
#8
Yanghe Wu, Jiguang Ding, Qingfeng Sun, Ke Zhou, Weiwei Zhang, Qingwei Du, Tingyan Xu, Wangwang Xu
Kupffer cells (KCs) play a crucial role in the pathogenesis of acute-on-chronic liver failure (ACLF) which is characterized by acute and severe disease in patients with preexisting liver disease and shows high mortality. Long noncoding RNAs (lncRNAs) are recently found to be involved in gene regulation. However, the mechanisms of how KCs are regulated by inflammatory factors, tumor necrosis factor-α (TNF-α), and whether lncRNAs are involved in the process remain largely unknown. Hence, we investigated the role of lncRNAs in the cytotoxicity of TNF-α on KCs...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29363576/the-long-non-coding-rna-gm10768-activates-hepatic-gluconeogenesis-by-sequestering-microrna-214-in-mice
#9
Xianwei Cui, Jingmin Tan, Yujie Shi, Chen Sun, Yun Li, Chenbo Ji, Jun Wu, Zhao Zhang, Siyu Chen, Xirong Guo, Chang Liu
Over-activated hepatic gluconeogenesis contributes to the pathogenesis of metabolic disorders, including type 2 diabetes. Precise control of hepatic gluconeogenesis thus is critical for maintaining whole-body metabolic homeostasis. Long non-coding RNAs (lncRNAs) have been shown to play key roles in diseases by regulating diverse biological processes, but the function of lncRNAs in maintaining normal physiology, particularly glucose homeostasis in the liver, remains largely unexplored. We identified a novel liver-enriched long non-coding RNA, Gm10768, and examined its expression patterns under pathophysiological conditions...
January 23, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29351317/hafts-are-novel-lncrna-transcripts-from-aflatoxin-exposure
#10
B Alex Merrick, Justin S Chang, Dhiral P Phadke, Meredith A Bostrom, Ruchir R Shah, Xinguo Wang, Oksana Gordon, Garron M Wright
The transcriptome can reveal insights into precancer biology. We recently conducted RNA-Seq analysis on liver RNA from male rats exposed to the carcinogen, aflatoxin B1 (AFB1), for 90 days prior to liver tumor onset. Among >1,000 differentially expressed transcripts, several novel, unannotated Cufflinks-assembled transcripts, or HAfTs (Hepatic Aflatoxin Transcripts) were found. We hypothesized PCR-cloning and RACE (rapid amplification of cDNA ends) could further HAfT identification. Sanger data was obtained for 6 transcripts by PCR and 16 transcripts by 5'- and 3'-RACE...
2018: PloS One
https://www.readbyqxmd.com/read/29321353/identification-and-association-of-novel-lncrna-poumu1-gene-mutations-with-chicken-performance-traits
#11
Tuanhui Ren, Yanting Zhou, Yu Zhou, Weihua Tian, Zhenzhen Gu, Song Zhao, Yadi Chen, Ruili Han, Xiaojun Liu, Xiangtao Kang, Zhuanjian Li
The biological functions of long noncoding RNAs (lncRNAs), which play an important role in regulating development and gene expression, may be affected by variations in lncRNA gene loci or associated genomic sequences. However, the functions of many lncRNAs remain unknown. To analyse correlations between mutations in pouMU1 with chicken growth and carcass traits, 860 chickens from a Gushi×Anka F2 resource population and 96 Lushi, Xichuan, Changshun and recessive white chickens were used to evaluate the genetic effect of the pouMU1 gene...
December 2017: Journal of Genetics
https://www.readbyqxmd.com/read/29317334/systematic-identification-of-rabbit-lncrnas-reveals-functional-roles-in-atherosclerosis
#12
Jia Li, Qianlan Yao, Fangyoumin Feng, Sheng He, Ping Lin, Liguang Yang, Chuhua Yang, Hong Li, Yixue Li
Long noncoding RNAs (lncRNAs) have been gradually emerging as important regulators in various biological processes and diseases, while the contributions of lncRNAs to atherosclerosis remain largely unknown. Our previous work has discovered atherosclerosis associated protein-coding genes by transcriptome sequencing of rabbit models. Here we investigated the roles of lncRNAs in atherosclerosis. We defined a stringent set of 3736 multi-exonic lncRNA transcripts in rabbits. All lncRNAs are firstly reported and 609 (16...
January 6, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29286922/lncrna-heih-in-serum-and-exosomes-as-a-potential-biomarker-in-the-hcv-related-hepatocellular-carcinoma
#13
Chun Zhang, Xi Yang, Quan Qi, Yuhai Gao, Qiang Wei, Shuwen Han
BACKGROUND: Chronic hepatitis C (CHC) is a contagious liver disease that results from infection with the hepatitis C virus (HCV). The most serious consequence of CHC is HCV-related hepatocellular carcinoma (HCC). OBJECTIVE: To illustrate the clinical significance of lncRNA HEIH expression in serum and exosomes in the development of HCV-related HCC. METHODS: Thirty-five CHC, twenty-two HCV-induced cirrhosis and ten HCV-related HCC patients in Huzhou Central Hospital from January 2016 to September 2016 were recruited in the present study...
December 22, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29228655/lncrna-svugp2-suppresses-progression-of-hepatocellular-carcinoma
#14
Jiangfeng Hu, Chenlin Song, Bensong Duan, Xiaoyan Zhang, Dongliang Li, Liang Zhu, Hengjun Gao
Numerous studies indicate that long noncoding RNAs (lncRNAs) are dysregulated in hepatocellular carcinoma (HCC) and might serve as potential diagnostic biomarkers and therapeutic targets of HCC. Therefore, it is interesting to globally identify the lncRNAs altered in HCC. In our study, we used microarray to profile the levels of lncRNAs and mRNAs in three pairs of HCC and their adjacent noncancerous samples. We found lncRNA-SVUGP2, which is a splice variant of the UGP2 gene, was down-regulated in HCC samples and correlates with a better prognosis in patients with HCC...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29219178/the-long-noncoding-rna-neat1-contributes-to-hepatocellular-carcinoma-development-by-sponging-mir-485-and-enhancing-the-expression-of-the-stat3
#15
Xu-Nan Zhang, Chang-Cheng Wang, Jun Zhou
Accumulating evidence has supported the significance of lncRNAs in tumorigenesis. Recently, some studies indicate the oncogenic role of lncRNA Nuclear Enriched Abundant Transcript 1 (NEAT1) in hepatocellular carcinoma (HCC). In our present study, we focused on the biological mechanisms through which NEAT1 can regulate HCC development. We found that NEAT1 was greatly upregulated in human HCC cell lines including Huh7, Hep3B, HepG2, Bel-7404 and SK-Hep1 cells compared to the normal human liver cell line LO2. In addition, we observed that miR-485 was significantly downregulated in HCC cells...
December 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29215608/h19-lncrna-alters-methylation-and-expression-of-hnf4%C3%AE-in-the-liver-of-metformin-exposed-fetuses
#16
Jie Deng, Martin Mueller, Tingting Geng, Yuanyuan Shen, Ya Liu, Peng Hou, Ramanaiah Ramillapalli, Hugh S Taylor, Michael Paidas, Yingqun Huang
Metformin is the most widely used anti-diabetic medication worldwide. However, human and animal studies suggest that prenatal metformin exposure may increase the risk of metabolic disorders in adult offspring, yet the underpinning mechanism remains unclear. Here we report that metformin-exposed mouse fetuses exhibit elevated expression of the H19 long noncoding RNA, which induces hypomethylation and increased expression of hepatocyte nuclear factor 4α (HNF4α). As a transcription factor essential for morphological and functional differentiation of hepatocytes, HNF4α also has an indispensable role in the regulation of expression of gluconeogenic genes...
December 7, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29196750/a-novel-y-specific-long-non-coding-rna-associated-with-cellular-lipid-accumulation-in-hepg2-cells-and-atherosclerosis-related-genes
#17
Elsa Molina, Guat S Chew, Stephen A Myers, Elyse M Clarence, James M Eales, Maciej Tomaszewski, Fadi J Charchar
There is an increasing appreciation for the role of the human Y chromosome in phenotypic differences between the sexes in health and disease. Previous studies have shown that genetic variation within the Y chromosome is associated with cholesterol levels, which is an established risk factor for atherosclerosis, the underlying cause of coronary artery disease (CAD), a major cause of morbidity and mortality worldwide. However, the exact mechanism and potential genes implicated are still unidentified. To date, Y chromosome-linked long non-coding RNAs (lncRNAs) are poorly characterized and the potential link between these new regulatory RNA molecules and hepatic function in men has not been investigated...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29189723/long-non-coding-rnas-in-metabolic-organs-and-energy-homeostasis
#18
REVIEW
Maude Giroud, Marcel Scheideler
Single cell organisms can surprisingly exceed the number of human protein-coding genes, which are thus not at the origin of the complexity of an organism. In contrast, the relative amount of non-protein-coding sequences increases consistently with organismal complexity. Moreover, the mammalian transcriptome predominantly comprises non-(protein)-coding RNAs (ncRNA), of which the long ncRNAs (lncRNAs) constitute the most abundant part. lncRNAs are highly species- and tissue-specific with very versatile modes of action in accordance with their binding to a large spectrum of molecules and their diverse localization...
November 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29187907/long-non-coding-rna-uiclm-promotes-colorectal-cancer-liver-metastasis-by-acting-as-a-cerna-for-microrna-215-to-regulate-zeb2-expression
#19
Dong-Liang Chen, Yun-Xin Lu, Jia-Xing Zhang, Xiao-Li Wei, Feng Wang, Zhao-Lei Zeng, Zhi-Zhong Pan, Yun-Fei Yuan, Feng-Hua Wang, Helene Pelicano, Paul J Chiao, Peng Huang, Dan Xie, Yu-Hong Li, Huai-Qiang Ju, Rui-Hua Xu
Long non-coding RNAs (lncRNAs) are involved in the pathology of various tumors, including colorectal cancer (CRC). However, the role of lncRNA in CRC liver metastasis remains unclear. Methods: a microarray was performed to identify the differentially expressed lncRNAs between CRC tissues with and without liver metastasis. Survival analysis was evaluated using the Kaplan-Meier method and assessed using the log-rank test. In vitro and in vivo assays were preformed to explore the biological effects of the differentially expressed lncRNA in CRC cells...
2017: Theranostics
https://www.readbyqxmd.com/read/29179477/long-noncoding-rna-nnt-as1-promotes-hepatocellular-carcinoma-progression-and-metastasis-through-mir-363-cdk6-axis
#20
Ye-Bin Lu, Qin Jiang, Man-Yi Yang, Ji-Xiang Zhou, Qi Zhang
Long non-coding RNAs (lncRNAs) have been tested to act as important regulator in liver cancer genesis and progression. LncRNA Nicotinamide Nucleotide Transhydrogenase-antisense RNA1 (NNT-AS1) has been reported to participate in the tumorigenesis. However, the exact molecular mechanism of NNT-AS1 in hepatocellular carcinoma (HCC) is still unknown. In present study, our team identified the up-regulated expression of NNT-AS1 in HCC tissue and cell lines compared with adjacent noncancerous tissue and normal cells...
October 24, 2017: Oncotarget
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