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lncRNA HCC

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https://www.readbyqxmd.com/read/29924905/a-long-non-coding-rna-expression-profile-can-predict-early-recurrence-in-hepatocellular-carcinoma-after-curative-resection
#1
Yufeng Lv, Wenhao Wei, Zhong Huang, Zhichao Chen, Yuan Fang, Lili Pan, Xueqiong Han, Zihai Xu
PURPOSE: The aim of this study was to develop a novel long non-coding RNA (lncRNA) expression signature to accurately predict early recurrence for patients with hepatocellular carcinoma (HCC) after curative resection. PATIENTS AND METHODS: Using expression profiles downloaded from The Cancer Genome Atlas database, we identified multiple lncRNAs with differential expression between early recurrence (ER) group and non-early recurrence (non-ER) group of HCC. Least absolute shrinkage and selection operator (LASSO) for logistic regression models were used to develop a lncRNA-based classifier for predicting ER in the training set...
June 20, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29905911/knockdown-of-sumo1p3-represses-tumor-growth-and-invasion-and-enhances-radiosensitivity-in-hepatocellular-carcinoma
#2
Yan Zhou, Ping He, Xuhua Xie, Changyu Sun
Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumors with high recurrence and metastasis rates. Radiotherapy represents a major therapeutic option for HCC patients. However, the efficacy of radiotherapy has been limited due to the development of intrinsic radioresistance of the tumor cells. Small ubiquitin-like modifier 1 pseudogene 3 (SUMO1P3), one member of SUMO pseudogene family, is a novel identified lncRNA that was originally identified to be upregulated in gastric cancer...
June 15, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29895332/long-noncoding-rna-hulc-accelerates-liver-cancer-by-inhibiting-pten-via-autophagy-cooperation-to-mir15a
#3
Xiaoru Xin, Mengying Wu, Qiuyu Meng, Chen Wang, Yanan Lu, Yuxin Yang, Xiaonan Li, Qidi Zheng, Hu Pu, Xin Gui, Tianming Li, Jiao Li, Song Jia, Dongdong Lu
BACKGROUND: Long noncoding RNA HULC is highly up-regulation in human hepatocellular carcinoma (HCC). However, the functions of HULC in hepatocarcinogenesis remains unclear. METHODS: RT-PCR, Western blotting, Chromatin immunoprecipitation (CHIP) assay, RNA Immunoprecipitation (RIP) and tumorignesis test in vitro and in vivo were performed. RESULTS: HULC is negatively associated with expression of PTEN or miR15a in patients of human liver cancer...
June 12, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29866133/long-non-coding-rna-ube2cp3-enhances-hcc-cell-secretion-of-vegfa-and-promotes-angiogenesis-by-activating-erk1-2-hif-1%C3%AE-vegfa-signalling-in-hepatocellular-carcinoma
#4
Jinduan Lin, Shunwang Cao, Yu Wang, Yanwei Hu, Hongwei Liu, Jiehua Li, Jing Chen, Pan Li, Jumei Liu, Qian Wang, Lei Zheng
BACKGROUND: Angiogenesis is considered as an important process in the development of malignancies and is associated with cancer progression and metastasis. Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver and is recognized as a typical angiogenic tumor. Thus, it is of great importance to study the underlying mechanism of angiogenesis in HCC. The long non-coding RNA (lncRNA) ubiquitin conjugating enzyme E2C pseudogene 3 (UBE2CP3) has been reported as an oncogene that promotes tumor metastasis in HCC...
June 4, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29864897/long-non-coding-rna-crnde-promotes-heptaocellular-carcinoma-cell-proliferation-by-regulating-pi3k-akt-%C3%AE-catenin-signaling
#5
Qiling Tang, Xiaoli Zheng, Junkai Zhang
Hepatocellular carcinoma (HCC) is one of the common malignant cancer worldwide, and its molecular pathogenesis remains elusive and recently long non-coding RNAs (lncRNAs) have been reported that play divergent roles in HCC tumorigenesis and development. In current study, we found a lncRNA, CRNDE is more commonly up-regulated in HCC malignant tissues and associated with poor clinical outcomes. Furthermore, both loss- and gain-functions assays revealed that CRNDE promotes HCC cell proliferation and growth in vitro and in vivo...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29845188/lncrna-ftx-promotes-aerobic-glycolysis-and-tumor-progression-through-the-ppar%C3%AE-pathway-in-hepatocellular-carcinoma
#6
Xiao Li, Qi Zhao, Jianni Qi, Wenwen Wang, Di Zhang, Zhen Li, Chengyong Qin
Aerobic glycolysis is a phenomenon by which malignant cells preferentially metabolize glucose through the glycolytic pathway, rather than oxidative phosphorylation to proliferate efficiently. The present study aimed to investigate the expression and functional implications of long non-coding (lnc)RNA Ftx in the aerobic glycolysis and tumorigenesis of hepatocellular carcinoma (HCC). It was identified that lncRNA Ftx was upregulated in human HCC tissues and cell lines and, notably, was associated with aggressive clinicopathological features...
May 23, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29844127/snhg6-acts-as-a-genome-wide-hypomethylation-trigger-via-coupling-of-mir-1297-mediated-s-adenosylmethionine-dependent-positive-feedback-loops
#7
Tao Guo, Hongling Wang, Pengpeng Liu, Yusha Xiao, Ping Wu, Yitao Wang, Baiyang Chen, Qiu Zhao, Zhisu Liu, Quanyan Liu
Aberrant genome-wide hypomethylation and long non-coding RNA (lncRNA) dysregulation are associated with hepatocarcinogenesis. However, whether a relationship between the two exists remains largely unknown. S-adenosylmethionine (SAMe)-dependent methylation is a critical factor in genomic methylation. We previously found that SNHG6 lncRNA acted as an oncogene in hepatocarcinogenesis and could be considered a potential prognostic indicator for hepatocellular carcinoma (HCC). Here we verify that SNHG6 leads to genome-wide hypomethylation in hepatoma cells and that SNHG6 negatively correlates with the steady-state SAMe concentration in vivo and in vitro...
May 29, 2018: Cancer Research
https://www.readbyqxmd.com/read/29805571/gene-gene-interaction-network-analysis-of-hepatocellular-carcinoma-using-bioinformatic-software
#8
Jin-Hua He, Ze-Ping Han, Pu-Zhao Wu, Mao-Xian Zou, Li Wang, Yu-Bing Lv, Jia-Bin Zhou, Ming-Rong Cao, Yu-Guang Li
Information processing tools and bioinformatics software have markedly advanced the ability of researchers to process and analyze biological data. Data from the genomes of humans and model organisms aid researchers to identify topics to study, which in turn improves predictive accuracy, facilitates the identification of relevant genes and simplifies the validation of laboratory data. The objective of the present study was to investigate the regulatory network constituted by long non-coding RNAs (lncRNAs), microRNAs (miRNAs) and mRNA in hepatocellular carcinoma (HCC)...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29803923/the-association-of-lncrna-hulc-polymorphisms-with-hepatocellular-cancer-risk-and-prognosis
#9
Ben-Gang Wang, Zhi Lv, Han-Xi Ding, Xin-Xin Fang, Jing Wen, Qian Xu, Yuan Yuan
BACKGROUND: Genetic polymorphisms in lncRNA HULC may affect the susceptibility and clinical outcome of cancer. We aimed to investigate the association of HULC tagSNPs with the risk and prognosis of hepatocellular cancer, as well as the influence of the SNPs on lncRNA expression level. METHODS: A total of 1338 samples were recruited in the risk study. Among them, 351 HCC patients were involved in the prognosis study. SNP genotyping was performed using KASP method and lncRNA expression was detected by Real-time PCR...
May 24, 2018: Gene
https://www.readbyqxmd.com/read/29803224/the-long-non-coding-rna-pttg3p-promotes-cell-growth-and-metastasis-via-up-regulating-pttg1-and-activating-pi3k-akt-signaling-in-hepatocellular-carcinoma
#10
Jin-Lan Huang, Shun-Wang Cao, Qi-Shui Ou, Bin Yang, Shi-Hao Zheng, Jing Tang, Jing Chen, Yan-Wei Hu, Lei Zheng, Qian Wang
BACKGROUND: Dysfunctions of long non-coding RNA (lncRNAs) have been associated with the initiation and progression of hepatocellular carcinoma (HCC), but the clinicopathologic significance and potential role of lncRNA PTTG3P (pituitary tumor-transforming 3, pseudogene) in HCC remains largely unknown. METHODS: We compared the expression profiles of lncRNAs in 3 HCC tumor tissues and adjacent non-tumor tissues by microarrays. In situ hybridization (ISH) and quantitative real-time polymerase chain reaction (qRT-PCR) were applied to assess the level of PTTG3P and prognostic values of PTTG3P were assayed in two HCC cohorts (n = 46 and 90)...
May 26, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29797561/neat1-upregulates-tgf-%C3%AE-1-to-induce-hepatocellular-carcinoma-progression-by-sponging-hsa-mir-139-5p
#11
Jianfei Tu, Zhongwei Zhao, Min Xu, Xiaojie Lu, Liu Chang, Jiansong Ji
Increasing evidence has shown that the lncRNA Nuclear Enriched Abundant Transcript 1 (NEAT1) play important roles in cell proliferation, migration, and invasion in various tumors. In our current study, we concentrated on the biological mechanisms of NEAT1 in hepatocellular carcinoma (HCC) development. It was found that NEAT1 was significantly increased in human HCC cell lines including Hep3B, LM3, MHCC97L, SK-hep1, and HepG2 cells compared to the normal human liver cell line LO2. Meanwhile, we observed that hsa-miR-139-5p was greatly decreased in HCC cells, which suggested a negative correlation between NEAT1 and hsa-mir-139-5p...
May 24, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29791864/lncrna-tug1-interacting-with-mir-144-contributes-to-proliferation-migration-and-tumorigenesis-through-activating-the-jak2-stat3-pathway-in-hepatocellular-carcinoma
#12
Jun Lv, Yongkui Kong, Zhiqiang Gao, Yanmin Liu, Pengfei Zhu, Zujiang Yu
Recently, it is reported that taurine upregulated gene 1 (TUG1) participates in the tumor progression by acting as a competing endogenous RNA (ceRNA) of miRNAs. Nonetheless, whether TUG1 could serve as a ceRNA of miR-144 in hepatocellular carcinoma (HCC) progression remains undefined. Here, our results indicated that there was a marked rise in TUG1 expression in HCC tissues and cells, and downregulation of TUG1 hindered proliferation and migration of HCC cells. Additionally, TUG1 was validated to act as a molecular sponge of miR-144...
May 20, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29790588/the-lncrna-casc9-and-rna-binding-protein-hnrnpl-form-a-complex-and-co-regulate-genes-linked-to-akt-signaling
#13
Marcel Klingenberg, Matthias Groß, Ashish Goyal, Maria Polycarpou-Schwarz, Thilo Miersch, Anne-Sophie Ernst, Jörg Leupold, Nitin Patil, Uwe Warnken, Heike Allgayer, Thomas Longerich, Peter Schirmacher, Michael Boutros, Sven Diederichs
The identification of viability-associated long non-coding RNAs (lncRNA) might be a promising rationale for new therapeutic approaches in liver cancer. Here, we applied the first RNAi screening approach in hepatocellular carcinoma (HCC) cell lines to find viability-associated lncRNAs. Among the multiple identified lncRNAs with a significant impact on HCC cell viability, we selected CASC9 (Cancer Susceptibility 9) due to the strength of its phenotype, expression, and upregulation in HCC versus normal liver. CASC9 regulated viability across multiple HCC cell lines as shown by CRISPR interference, single siRNA- and siPOOL-mediated depletion of CASC9...
May 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29789998/the-expression-and-role-of-lncrna-ax800134-in-hepatitis-b-virus-related-hepatocellular-carcinoma
#14
Kai Zuo, Li Kong, Dong Xue, Yanyan Yang, Linlin Xie
Chronic infection with hepatitis B virus (HBV) is one of most important risk factors for the development of hepatocellular carcinoma (HCC). Several long non-coding RNAs (lncRNAs) have been shown to be involved in the etiology of HBV-related HCC. AX800134 is one recently identified lncRNA associated with HCC. In this study, we validated the upregulated expression of AX800134 in HBV-positive HCC compared with HBV-negative HCC. Furthermore, we found that HBV X protein (HBx) directly triggered AX800134 expression in human hepatoma HepG2 cells...
May 22, 2018: Virus Genes
https://www.readbyqxmd.com/read/29780284/up-regulation-of-ctd-2547g23-4-in-hepatocellular-carcinoma-tissues-and-its-prospective-molecular-regulatory-mechanism-a-novel-qrt-pcr-and-bioinformatics-analysis-study
#15
Dong-Yue Wen, Peng Lin, Hai-Wei Liang, Xia Yang, Hai-Yuan Li, Yun He, Hong Yang, Gang Chen
Background: Dysregulated expression of long non-coding RNAs (lncRNAs) has been reported in the pathogenesis and progression of multiple cancers, including hepatocellular carcinoma (HCC). LncRNA CTD-2547G23.4 is a novel lncRNA, and its role in HCC is still unknown. Here, we aimed to clarify the expression pattern and clinical value of CTD-2547G23.4 and to investigate the prospective regulatory mechanism via bioinformatics analysis in HCC. Methods: To identify differentially expressed lncRNAs in HCC, we downloaded RNA-Seq data for HCC and adjacent non-tumour tissues via The Cancer Genome Atlas (TCGA)...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29778425/lncrna-hotair-contributes-to-the-malignancy-of-hepatocellular-carcinoma-by-enhancing-epithelial-mesenchymal-transition-via-sponging-mir-23b-3p-from-zeb1
#16
Tao Yang, Xiaojun He, An Chen, Kai Tan, Xilin Du
Hepatocellular carcinoma (HCC) is the fifth most common cancer around the world, along with high mortality and metastasis rate. Our present study aimed to explore the role of LncRNA HOTAIR in the progression of HCC. Our data showed that HOTAIR was overexpressed in HCC tissues and cell lines (Huh7, Hep3B, HepG2, MHCC97H). Overexpressed HOTAIR promoted invasion and migration of HCC cells (Huh7) by enhancing epithelial-mesenchymal transition (EMT). Besides that, miR-23b-3p was predicted to be a target of HOTAIR and decreased expression of miR-23b-3p was observed in HCC tissues and cell lines...
May 17, 2018: Gene
https://www.readbyqxmd.com/read/29776974/the-long-noncoding-rna-lncparp1-contributes-to-progression-of-hepatocellular-carcinoma-through-upregulation-of-parp1
#17
Heqiang Qi, Yuyan Lu, Jie Lv, Huita Wu, Jing Lu, Changmao Zhang, Sheng Zhang, Qing Bao, Xiuming Zhang, Chengrong Xie, Zhenyu Yin
Hepatocellular carcinoma (HCC) accounts for a large proportion of cancer-associated mortality worldwide. The functional impact of long noncoding RNAs (lncRNAs) in human cancer is not fully understood. Here, we identified a novel oncogenic lncRNA termed lncPARP1, which was significantly upregulated in HCC. Increase of lncPARP1 expression was associated with age, AFP levels, tumor size, recurrence, and poor prognosis of HCC patients. Loss-of-function approaches showed that knockdown of lncPARP1 inhibited proliferation, migration and invasion, while induced apoptosis in HCC cells...
May 18, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29772433/lncrna-sox21-as1-is-associated-with-progression-of-hepatocellular-carcinoma-and-predicts-prognosis-through-epigenetically-silencing-p21
#18
Congxin Wei, Hong Wang, Fei Xu, Zeng Liu, Runde Jiang
Long non-coding RNAs (lncRNAs) have been widely reported in various cancers due to their special molecular mechanisms. LncRNA SOX21-AS1 has been discovered to be a tumor facilitator in several types of human cancers. However, the expression pattern, clinical value and biological effects in hepatocellular carcinoma (HCC) are still unknown. In this study, we detected the high expression level of SOX21-AS1 in tumor tissues and cell lines through performing qRT-PCR analysis. The prognostic value of SOX21-AS1 was identified...
May 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29764424/long-non-coding-rna-neat1-modulated-abnormal-lipolysis-via-atgl-drives-hepatocellular-carcinoma-proliferation
#19
Xirui Liu, Yingjian Liang, Ruipeng Song, Guangchao Yang, Jihua Han, Yaliang Lan, Shangha Pan, Mingxi Zhu, Yao Liu, Yan Wang, Fanzheng Meng, Yifeng Cui, Jiabei Wang, Bo Zhang, Xuan Song, Zhaoyang Lu, Tongsen Zheng, Lianxin Liu
BACKGROUND: Abnormal metabolism, including abnormal lipid metabolism, is a hallmark of cancer cells. Some studies have demonstrated that the lipogenic pathway might promote the development of hepatocellular carcinoma (HCC). However, the role of the lipolytic pathway in HCC has not been elucidated. METHODS: We compared levels of adipose triglyceride lipase (ATGL) in human HCC and healthy liver tissues by real time PCR, western blot and immunohistochemistry. We measured diacylglycerol(DAG) and free fatty acid (FFA) levels in HCC cells driven by the NEAT1-ATGL axis and in HCC tissues...
May 15, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29761918/lncrna-hoxa11-as-promotes-hepatocellular-carcinoma-progression-by-repressing-mir-214-3p
#20
Meixiao Zhan, Ke He, Jing Xiao, Fei Liu, Haihe Wang, Zhenglin Xia, Xiaopeng Duan, Rui Huang, Yong Li, Xu He, Hua Yin, Guoan Xiang, Ligong Lu
Accumulating studies supported that lncRNAs played important roles in tumorigenesis. LncRNA HOXA11-AS was a novel lncRNA that has been proved to involved in several tumours. However, the role of HOXA11-AS in the development of hepatocellular carcinoma (HCC) remains to be explained. In our study, we showed that HOXA11-AS expression was up-regulated in the HCC tissues, and the higher expression of HOXA11-AS was associated with the advanced stage in the HCC samples. In addition, we indicated that the expression of HOXA11-AS was up-regulated in HCC cell lines (Hep3B, SMMC-7721, MHCC97-H and BEL-7402) compared with normal liver cell lines (HL-7702)...
May 15, 2018: Journal of Cellular and Molecular Medicine
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