Chunyang Fan, Jiacheng Du, Zilin Yu, Jiale Wang, Lingye Yao, Zhongwei Ji, Wei He, Yongkang Deng, Dechun Geng, Xiexing Wu, Haiqing Mao
Intervertebral disc degeneration (IVDD) stands as the primary cause of low back pain (LBP). A significant contributor to IVDD is nucleus pulposus cell (NPC) senescence. However, the precise mechanisms underlying NPC senescence remain unclear. Monoacylglycerol lipase (MAGL) serves as the primary enzyme responsible for the hydrolysis of 2-arachidonoylglycerol (2-AG), breaking down monoglycerides into glycerol and fatty acids. It plays a crucial role in various pathological processes, including pain, inflammation, and oxidative stress...
March 21, 2024: International Immunopharmacology