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Mechanical back pain

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https://www.readbyqxmd.com/read/28224704/advanced-glycation-end-products-regulate-anabolic-and-catabolic-activities-via-nlrp3-inflammasome-activation-in-human-nucleus-pulposus-cells
#1
Yu Song, Yan Wang, Yukun Zhang, Wen Geng, Wei Liu, Yong Gao, Shuai Li, Kun Wang, Xinghuo Wu, Liang Kang, Cao Yang
Intervertebral disc degeneration is widely recognized as a cause of lower back pain, neurological dysfunction and other musculoskeletal disorders. The major inflammatory cytokine IL-1β is associated with intervertebral disc degeneration; however, the molecular mechanisms that drive IL-1β production in the intervertebral disc, especially in nucleus pulposus (NP) cells, are unknown. In some tissues, advanced glycation end products (AGEs), which accumulate in NP tissues and promote its degeneration, increase oxidative stress and IL-1β secretion, resulting in disorders, such as obesity, diabetes mellitus and ageing...
February 22, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28216399/minimally-invasive-sacroiliac-joint-fusion-using-a-novel-hydroxyapatite-coated-screw-preliminary-1-year-clinical-and-radiographic-results-of-a-2-year-prospective-study
#2
Louis H Rappoport, Ingrid Y Luna, Gita Joshua
OBJECTIVE: Proper diagnosis and treatment of sacroiliac joint (SIJ) pain remains a clinical challenge. Dysfunction of SIJ can produce pain in the lower back, buttocks, and extremities. Triangular titanium implants for minimally invasive surgical arthrodesis have been available for several years with reputed high levels of success and patient satisfaction. This study reports on a novel hydroxyapatite-coated screw for surgical treatment of SIJ pain. METHODS: Data were prospectively collected on 32 consecutive patients who underwent minimally invasive SIJ fusion with a novel hydroxyapatite-coated screw...
February 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28214616/exploring-factors-influencing-low-back-pain-in-people-with-non-dysvascular-lower-limb-amputation-a-national-survey
#3
Hemakumar Devan, Paul Hendrick, Leigh Hale, Allan Carman, Michael P Dillon, Daniel Cury Ribeiro
BACKGROUND: Chronic low back pain (LBP) is a common musculoskeletal impairment in people with lower limb amputation. Given the multifactorial nature of LBP, exploring the factors influencing the presence and intensity of LBP is warranted. OBJECTIVE: To investigate which physical, personal, and amputee-specific factors predicted presence and intensity of low back pain (LBP) in persons with non-dysvascular transfemoral (TFA) and transtibial amputation (TTA). DESIGN: A retrospective cross-sectional survey SETTING: A national random sample of people with non-dysvascular TFA and TTA...
February 15, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28208824/associations-between-obesity-and-spinal-diseases-a-medical-expenditure-panel-study-analysis
#4
Binwu Sheng, Chaoling Feng, Donglan Zhang, Hugh Spitler, Lu Shi
Background: The link between body weight status and spinal diseases has been suggested by a number of cross-sectional and cohort studies with a limited range of patient populations. No population-representative samples have been used to examine the link between obesity and spinal diseases. The present study is based on a nationally representative sample drawn from the Medical Expenditure Panel Survey. Methods: Using the cross-sectional sample of the 2014 Medical Expenditure Panel Study, we built four weighted logistic regression analyses of the associations between body weight status and the following four spinal diseases: low back pain, spondylosis, other cervical disorders and intervertebral disc disorder (IDD)...
February 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28207662/expression-of-mirna-124a-in-cd4-cells-reflects-response-to-a-multidisciplinary-treatment-program-in-patients-with-chronic-low-back-pain
#5
Benjamin Luchting, Jens Heyn, Ludwig Christian Hinske, Shahnaz Christina Azad
STUDY DESIGN: A prospective evaluation of microRNA (miRNA) expression in patients with chronic low back pain (CLBP). OBJECTIVE: The aim of this study was to evaluate whether pain- and T cell-related miRNAs are differentially expressed in CLBP when compared with healthy volunteers and whether these miRNAs may distinguish between responders and nonresponders to a multidisciplinary treatment program. SUMMARY OF BACKGROUND DATA: CLBP is a common health problem worldwide...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28194840/burst-spinal-cord-stimulation-increases-peripheral-antineuroinflammatory-interleukin-10-levels-in-failed-back-surgery-syndrome-patients-with-predominant-back-pain
#6
Thomas M Kinfe, Sajjad Muhammad, Carolina Link, Sandra Roeske, Shafqat R Chaudhry, Thomas L Yearwood
OBJECTIVES: Burst spinal cord stimulation (SCS) has been reported to reduce back pain and improve functional capacity in Failed Back Surgery Syndrome (FBSS). However, its mechanism of action is not completely understood. Systemic circulating cytokines have been associated with the development of chronic back pain. METHODS: This prospective, feasibility study enrolled 12 refractory FBSS patients with predominant back pain (70% of overall pain) suitable for Burst SCS...
February 13, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28187075/investigating-the-association-between-lower-extremity-and-low-back-symptoms-among-saskatchewan-farmers-using-the-standardized-nordic-questionnaire
#7
Samuel Kwaku Essien, Catherine Trask, James Dosman, Brenna Bath
STUDY DESIGN: Cross sectional survey OBJECTIVE.: To investigated the association between self-reported low back symptoms and symptoms in the hip, knee, and ankle in a high-risk occupational group SUMMARY OF BACKGROUND DATA.: Low back pain, with or without lower extremity referral, poses a major challenge to occupational productivity, especially in farming. Although low back symptoms can occur independent of lower extremity symptoms, anatomical positioning of nerves supplying the lower limbs means structural and physiological changes in the spine can lead to referred pain in the lower limbs, but the magnitude of the association between low back and lower extremity symptoms is unclear...
February 9, 2017: Spine
https://www.readbyqxmd.com/read/28186946/gabapentinoids-for-chronic-low-back-pain-a-protocol-for-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#8
Harsha Shanthanna, Ian Gilron, Lehana Thabane, Philip J Devereaux, Mohit Bhandari, Rizq AlAmri, Manikandan Rajarathinam, Sriganesh Kamath
INTRODUCTION: Chronic low back pain (CLBP) is a common condition and causes significant pain, distress and disability across the world. It is multifactorial in aetiology and is challenging to manage. Although the underlying mechanism of pain is predominantly non-specific, many argue that there is a substantial neuropathic pain element. Neuropathic pain is more severe, with significant disability. Gabapentinoids, including gabapentin and pregabalin, have proven efficacy in some neuropathic pain conditions...
November 10, 2016: BMJ Open
https://www.readbyqxmd.com/read/28183502/a-27-year-old-man-with-acute-severe-low-back-pain-and-bilateral-leg-swelling-that-prompted-renting-a-wheelchair-for-mobility
#9
John G Williams, Huy Phan, Helena R Winston, Randolph V Fugit, Bridget Graney, Brant Jamroz, Benjamin English, Edward D Chan
A 27-year-old man with OSA, posttraumatic stress disorder, and chronic mechanical back pain presented with a 3-day history of acute atraumatic worsening of his low back pain as well as right groin numbness that was exacerbated by walking. He also complained of bilateral leg "heaviness," pain, and swelling, all becoming so severe that he rented a wheelchair for mobility.
February 2017: Chest
https://www.readbyqxmd.com/read/28183360/fat-mass-and-fat-distribution-are-associated-with-low-back-pain-intensity-and-disability-results-from-a-cohort-study
#10
Sultana Monira Hussain, Donna M Urquhart, Yuanyuan Wang, Jonathan E Shaw, Dianna J Magliano, Anita E Wluka, Flavia M Cicuttini
BACKGROUND: Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim of this study was to examine the relationship between body composition and LBP intensity and disability. METHODS: A total of 5058 participants (44% men) of the Australian Diabetes, Obesity and Lifestyle Study were assessed for LBP intensity and disability using the Chronic Pain Grade Questionnaire (2013-2014)...
February 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28176921/increased-local-expressions-of-cx3cl1-and-ccl2-are-related-to-clinical-severity-in-lumbar-disk-herniation-patients-with-sciatic-pain
#11
Zhen-Yu Peng, Rui Chen, Zuo-Zhong Fang, Bin Chen, Zhi-Hua Wang, Xi-Yang Wang
BACKGROUND: Chemokines have been identified to be involved in the modulation of pain through both peripheral and central mechanisms. However, the role of chemokines in lumbar disk herniation (LDH) with sciatic pain remains unknown. OBJECTIVE: The current study was performed to explore the expression of two most commonly studied chemokines CX3CL1 and CCL2 and assess their associations with clinical severity in LDH patients with sciatic pain. METHODS: The soft tissues around nerve root (STANR), annulus fibrosus (AF), and nucleus pulposus (NP) biopsies were obtained from 36 LDH patients with chronic sciatic pain and 10 scoliosis patients (painless controls)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28175941/-health-related-quality-of-life-after-mechanical-ventilation-in-the-intensive-care-unit
#12
D Schädler, L Kaiser, B Malchow, T Becher, G Elke, I Frerichs, T Küchler, N Weiler
BACKGROUND: It is unknown whether health related quality of life measured in German patients one year after mechanical ventilation in the intensive care unit is impaired or not. OBJECTIVES: The aim of this study was to assess health related quality of life one year after inclusion into a randomized controlled trial for weaning from mechanical ventilation with the help of a questionnaire that has never been used in critically ill patients and to investigate whether health related quality of life scores differ between the study population and a general German population...
February 7, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28167175/effect-of-melt-method-on-thoracolumbar-connective-tissue-the-full-study
#13
Faria Sanjana, Hans Chaudhry, Thomas Findley
Altered connective tissue structure has been identified in adults with chronic low back pain (LBP). A self-care treatment for managing LBP is the MELT method. The MELT method is a hands-off, self-treatment that is said to alleviate chronic pain, release tension and restore mobility, utilizing specialized soft treatments balls, soft body roller and techniques mimicking manual therapy. The objective of this study was to determine whether thickness of thoracolumbar connective tissue and biomechanical and viscoelastic properties of myofascial tissue in the low back region change in subjects with chronic LBP as a result of MELT...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28164163/change-of-sagittal-spinal-alignment-and-its-association-with-pain-and-function-after-lumbar-surgery-augmented-with-an-interspinous-implant
#14
Rebecca J Crawford, Quentin J Malone, Roger I Price
BACKGROUND: Interspinous spacer/implants like the Device for Intervertebral Assisted Motion (DIAM™) are controversially yet commonly used in the surgical treatment of lumbar degenerative pathologies. Criticism is based on ill-defined indications, lack of superiority over decompression, and a poorly understood mechanical effect. Yet, continued use by surgeons implies their perceived clinical merit. We examined radiographic spinal alignment for 12 months, and pain and function for 24 months, after DIAM-augmented surgery to improve the understanding of the mechanical effect relating to clinical outcomes in patients...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28154973/progression-of-postural-changes-in-parkinson-s-disease-quantitative-assessment
#15
Alexander Khlebtovsky, Ruth Djaldetti, Yaniv Rodity, Ofir Keret, Gloria Tsvetov, Ilana Slutzcki-Shraga, Felix Benninger
Previous studies of posture in Parkinson's disease (PD) patients focused on the pathophysiology of severe deformities, using mainly subjective estimations or goniometric measures. The aim of this study was to investigate risk factors associated with flexed posture in PD and their effects on the course of posture variations. One hundred-ninety patients with definite PD were prospectively evaluated for angles of spinal inclination in upright position, extension, and flexion using a mechanical computer-assisted, hand-held device (SpinalMouse)...
February 2, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28150180/pelvic-posture-and-kinematics-in-femoroacetabular-impingement-a-systematic-review
#16
REVIEW
Luca Pierannunzii
BACKGROUND: Pelvic posture and kinematics influence acetabular orientation and are therefore expected to be involved in the pathomechanics of femoroacetabular impingement (FAI). This systematic review aims to determine whether FAI patients show pelvic postures or patterns of motion contributing to impingement or, conversely, develop compensatory postures and patterns of motion preventing it. MATERIALS AND METHODS: PubMed/MEDLINE, Embase, Google Scholar and the Cochrane Library were systematically searched to find all the studies that measured pelvic positional and/or kinematic data in humans (patients or cadaveric specimens) affected by FAI...
February 1, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28149258/the-prevalence-of-chronic-pain-in-orchestra-musicians
#17
Elena R Gasenzer, Marie-Juliana Klumpp, Dawid Pieper, Edmund A M Neugebauer
Background: The study investigated the incidence of chronic pain as well as causes and mechanisms of pain chronification in orchestra musicians. Aims: Chronic pain is a serious problem in the study group due to very specific playing techniques and body positions while playing, with a high impact on professional and private life. Methods: 8,645 professional musicians from 132 German cultural orchestras were contacted and asked about chronic pain via an online questionnaire. The study group comprised orchestra musicians suffering from pain...
2017: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/28144848/the-fabrication-of-cryogel-scaffolds-incorporated-with-poloxamer-407-for-potential-use-in-the-regeneration-of-the-nucleus-pulposus
#18
Nicholas A Temofeew, Katherine R Hixon, Sarah H McBride-Gagyi, Scott A Sell
Degeneration of the nucleus pulposus (NP) is the primary cause of back pain in almost 80% of the world population. The current gold standard treatment for a degenerated NP is a spinal fusion surgery which is costly, temporary, and extremely invasive. Research has been moving towards minimally invasive methods to lessen the collateral damage created during surgery. The use of a tissue-engineered scaffold has the potential to promote a healthy and hydrated environment to regenerate the NP. Cryogels are unique polymeric scaffolds composed of a highly connected, macroporous structure, and are capable of maintaining stability under high deformations...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28142364/increasing-recreational-physical-activity-in-patients-with-chronic-low-back-pain-a-pragmatic-controlled-clinical-trial
#19
Noa Ben-Ami, Gabriel Chodick, Yigal Mirovsky, Tamar Pincus, Yair Shapiro
Study Design Prospective, pragmatic, nonrandomized controlled clinical trial. Background Clinical guidelines recommend physical activity for the treatment of chronic low back pain. But engaging patients in physical activity has proven difficult. Known obstacles to physical activity include low self-efficacy and fear avoidance. Objectives This study tested the effectiveness of an enhanced transtheoretical model intervention (ETMI) aimed at increasing recreational physical activity in patients with chronic low back pain, in comparison to usual physical therapy...
February 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28140673/lower-extremity-and-spine-characteristics-in-young-dancers-with-and-without-patellofemoral-pain
#20
Nili Steinberg, Shay Tenenbaum, Israel Hershkovitz, Aviva Zeev, Itzhak Siev-Ner
Very little is known about patellofemoral pain syndrome (PPFS) among young dancers. Understanding the mechanism of the injury and implementing a preventative programme are important in order to minimize the risk of PFPS. The aim of the current study is to determine the extent to which factors such as lower extremity and back characteristics are common among dancers with PFPS. The study population included 271 dancers with PFPS and 271 non-injured dancers, aged 10-16 years. All dancers were screened for morphometric profile, dance discipline (h/week), anatomical anomalies (present/absent of scoliosis, genu valgus/varum, etc...
January 31, 2017: Research in Sports Medicine
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