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Mechanical back pain

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https://www.readbyqxmd.com/read/28430617/estrogen-receptors-involvement-in-intervertebral-discogenic-pain-of-the-elderly-women-colocalization-and-correlation-with-the-expression-of-substance-p-in-nucleus-pulposus
#1
Xiao-Xing Song, Sheng Shi, Zhen Guo, Xin-Feng Li, Bu-Wei Yu
Estrogenic modulation of pain is an exceedingly complex phenomenon. However, whether estrogen is involved in discogenic low back pain still remains unclear. Here, immunoreactivity staining technique was used to examine the expression level of the estrogen receptors (ERα and ERβ) and a pain related neuropeptide, Substance P in the lumbar intervertebral discs to analyze the relationship between the ERs and Substance P. Nucleus pulposus tissues of 23 elderly female patients were harvested during spinal surgeries and made to detect the immunoreactivity staining of ERα, ERβ and Substance P...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429337/from-acute-to-chronic-pain-tapentadol-in-the-progressive-stages-of-this-disease-entity
#2
F Coluzzi, D Fornasari, J Pergolizzi, P Romualdi
OBJECTIVE: Chronic pain is now recognized as a neural disease, which results from a maladaptive functional and structural transformation process occurring over time. In its chronic phase, pain is not just a symptom but also a disease entity. Therefore, pain must be properly addressed, as many patients still report unsatisfactory pain control despite on-going treatment. The selection of the therapy - taking into account the pathophysiological mechanisms of pain - and the right timing can result in a successful analgesic outcome...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28423222/persistent-and-developing-sleep-problems-a-prospective-cohort-study-on-the-relationship-to-poor-outcome-in-patients-attending-a-pain-clinic-with-chronic-low-back-pain
#3
Amir H Pakpour, Mohammadhossein Yaghoubidoust, P Campbell
Sleep problems are common in people with low back pain (LBP), however the mechanisms on how sleep influences pain are complex. To date there is a lack of prospective research on the timings and the development of sleep problems in those who have LBP, such information would be useful to identify individuals at risk of poor outcome. Aims are to investigate the predictive role of sleep problems on self-report recovery and pain intensity using logistic regression reporting Odds Ratios (OR). An observational cohort of 761 chronic LBP patients recruited from a pain management clinic participated, and completed data at baseline, and at 6 month follow-up (n = 682)...
April 18, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28420499/the-associations-between-parity-other-reproductive-factors-and-osteoarthritis-in-women-aged-over-50-years-data-from-the-korean-national-health-and-nutrition-examination-survey-v-2010-2012
#4
Su Mi Kim, Ju-Young Cheon, Yong-Gyu Park, Hae-Rim Kim, Jong Chul Shin, Hyun Sun Ko
OBJECTIVE: To evaluate the relationships between sociodemographic factors, reproductive history, and subsequent risk of osteoarthritis (OA) or pain of the hip, knee, and back in Korean women. MATERIALS AND METHODS: This study included data of 5101 women aged over 50 years, taken from the Korean National Health and Nutritional Examination Survey V from 2010 to 2012. Women were stratified according to parity, as well as delivery mode. Multivariate logistic regression analysis was conducted to evaluate relationships between radiographic OA or symptomatically possible OA (back, knee, or hip), and historical factors...
April 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28418945/tendonitis-and-tendon-rupture-after-treatment-with-rituximab-a-case-series
#5
Ali Alqahtani, Marwa Sabha, Thaer Abdelfattah, Khaled Srour, Turki Dhayihi, Bashar Kahaleh, Nezam Altorok
CLINICAL DATA: Rituximab is a mouse/human chimeric anti-CD20 IgG1 monoclonal antibody used to treat cancer and autoimmune conditions. Side effects of rituximab include fever, rash, cytopenia and hypotension, back pain, arthralgia, and myalgia. Here, we report on 3 patients who developed moderate to severe tendonitis after the second infusion of rituximab. THERAPEUTIC CHALLENGE: We report 3 patients who developed tendonitis after the second infusion of rituximab...
April 14, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28397030/electroencephalographic-evidence-of-altered-top-down-attentional-modulation-in-fibromyalgia-patients-during-a-working-memory-task
#6
Alberto J González-Villar, Marina Pidal-Miranda, Manuel Arias, Dolores Rodríguez-Salgado, María T Carrillo-de-la-Peña
Fibromyalgia (FM) is a chronic syndrome involving widespread pain of unclear pathophysiology. FM patients frequently complain about cognitive symptoms that interfere with their daily life activities. Several studies have reported attentional deficits and working memory impairment in FM patients. Nevertheless, the mechanisms involved in these alterations are still poorly understood. In this study we recorded electroencephalographic activity in 32 women with FM and 30 matched controls while they performed a 2-back working memory task...
April 10, 2017: Brain Topography
https://www.readbyqxmd.com/read/28389378/sympathetic-regulation-and-anterior-cingulate-cortex-volume-are-altered-in-a-rat-model-of-chronic-back-pain
#7
Sara Touj, Sébastien Houle, Djamel Ramla, Renaud Jeffrey-Gauthier, Harumi Hotta, Gilles Bronchti, Maria-Grazia Martinoli, Mathieu Piché
Chronic pain is associated with autonomic disturbance. However, specific effects of chronic back pain on sympathetic regulation remain unknown. Chronic pain is also associated with structural changes in the anterior cingulate cortex (ACC), which may be linked to sympathetic dysregulation. The aim of this study was to determine whether sympathetic regulation and ACC surface and volume are affected in a rat model of chronic back pain, in which complete Freund Adjuvant (CFA) is injected in back muscles. Sympathetic regulation was assessed with renal blood flow (RBF) changes induced by electrical stimulation of a hind paw, while ACC structure was examined by measuring cortical surface and volume...
April 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/28387936/the-plasticity-of-descending-controls-in-pain-translational-probing
#8
Kirsty Bannister, A H Dickenson
Descending controls, comprising pathways that originate in midbrain and brainstem regions and project onto the spinal cord, have long been recognized as key links in the multiple neural networks that interact to produce the overall pain experience. There is clear evidence from preclinical and clinical studies that both peripheral and central sensitisation play important roles in determining the level of pain perceived. Much emphasis has been put on spinal cord mechanisms in central excitability, but it now becoming clear that spinal hyperexcitability can be regulated by descending pathways from the brain that originate from predominantly noradrenergic and serotonergic systems...
April 7, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28387658/do-turkish-patients-with-lumbar-disc-herniation-know-body-mechanics
#9
Sacide Yildizeli Topcu
BACKGROUND AND OBJECTIVE: Most common and important cause of the low back pain is lumbar disc herniation. Patients with lumbar disc herniation face with difficulties during daily activities due to the reduction of physical functions. In order to maintain daily activities without pain and discomfort, the patients should be informed about proper positions and body mechanics. The aim of the study was to determine the knowledge and the applications of the patients with lumbar disc herniation about body mechanics...
March 31, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28387615/ectopic-expression-of-smurf2-and-acceleration-of-age-related-intervertebral-disc-degeneration-in-a-mouse-model
#10
Qiuqian Wu, Jason H Huang
OBJECTIVE Lumbar intervertebral disc degeneration, an age-related process, is a major cause of low-back pain. Although low-back pain is a very common clinical problem in the aging population, no effective treatment is available, largely owing to lack of understanding of the molecular mechanisms underlying disc degeneration. The goal of this study was to characterize how ectopic expression of Smurf2 driven by the collagen Type II alpha 1 ( Col2a1) promoter alters disc cell phenotype and associated cellular events, matrix synthesis, and gene expression during disc degeneration in mice...
April 7, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28380300/biophysical-study-on-the-interaction-between-eperisone-hydrochloride-and-human-serum-albumin-using-spectroscopic-calorimetric-and-molecular-docking-analysis
#11
Gulam Rabbani, Mohammad Hassan Baig, Eun Ju Lee, Won Kyung Cho, Jin Yeul Ma, Inho Choi
Eperisone hydrochloride (EH) is a widely used as a muscle relaxant for patients with muscular contracture, low back pain, or spasticity. Human serum albumin (HSA), a highly soluble negatively charged, endogenous and abundant plasma protein ascribed with the ligand binding and transport properties. The current study was undertaken to explore the interaction between EH and the serum transport protein, HSA. Study of the interaction between HSA and EH was carried by UV-vis, fluorescence quenching, circular dichroism (CD) spectroscopy, FRET, and ITC...
April 5, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28376786/psychological-predictors-of-change-in-the-number-of-musculoskeletal-pain-sites-among-norwegian-employees-a-prospective-study
#12
Jan Olav Christensen, Sissel Johansen, Stein Knardahl
BACKGROUND: The pathogenesis of syndromes of widespread musculoskeletal pain remains an enigma. The present study sought to determine if psychological states, job satisfaction, pain intensity, and sleep problems contributed to the spread and decline of the number of musculoskeletal pains. METHODS: A sample of 2989 Norwegian employees completed a questionnaire at baseline and follow-up 2 years later. Data were analyzed with multinomial and ordinal logistic regression analyses to determine effects on direction and degree of change of number of pain sites (NPS)...
April 4, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28376368/brain-derived-neurotrophic-factor-plasma-levels-are-increased-in-older-women-after-an-acute-episode-of-low-back-pain
#13
Juliano Bergamaschine Mata Diz, Bruno de Souza Moreira, Diogo Carvalho Felício, Luiza Faria Teixeira, Fabianna Resende de Jesus-Moraleida, Bárbara Zille de Queiroz, Daniele Sirineu Pereira, Leani Souza Máximo Pereira
BACKGROUND: Low back pain (LBP) is a growing public health problem in old age, and it is associated with disabling pain and depressive disorders. We compared brain-derived neurotrophic factor (BDNF) plasma levels, a key neurotrophin in pain modulation, between older women after an acute episode of LBP and age-matched pain-free controls, and investigated potential differences in BDNF levels between controls and LBP subgroups based on pain severity, presence of depressive symptoms and use of analgesic and antidepressant drugs...
March 22, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28371810/characteristics-of-the-musculoskeletal-symptoms-observed-among-survivors-of-ebola-virus-disease-in-the-postebogui-cohort-in-guinea
#14
Yves-Marie Pers, Mamadou Saliou Sow, Bernard Taverne, Laura March, Suzanne Izard, Jean François Étard, Moumié Barry, Abdoulaye Touré, Eric Delaporte
Objective.: Previous studies show that arthralgia is the most common symptom experienced by Ebola virus disease (EVD) survivors. Nevertheless, specific analyses of rheumatological sequelea are still lacking. Methods.: The Postebogui study is a prospective, multicentre cohort aiming to evaluate the long-term outcomes of EVD survivors infected during the 2014-15 outbreak in Guinea. Of the 216 participants enrolled in the study in October 2015, 44 patients with arthralgia/myalgia underwent a physical examination by a rheumatologist (the Eborheum cohort)...
March 22, 2017: Rheumatology
https://www.readbyqxmd.com/read/28369946/does-exercise-increase-or-decrease-pain-central-mechanisms-underlying-these-two-phenomena
#15
Lucas V Lima, Thiago S S Abner, Kathleen A Sluka
Exercise is an integral part of the rehabilitation of patients suffering a variety of chronic musculoskeletal conditions, such as fibromyalgia, chronic low back pain and myofascial pain. Regular physical activity is recommended for treatment of chronic pain and its effectiveness has been established in clinical trials for people with a variety of pain conditions. However, exercise can also increase pain making participation in rehabilitation challenging for the person with pain. Animal models of exercise-induced pain have been developed and point to central mechanisms underlying this phenomena, such as increased activation of NMDA receptors in pain-modulating areas...
March 29, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28369107/mapping-the-association-between-back-pain-and-type-2-diabetes-a-cross-sectional-and-longitudinal-study-of-adult-spanish-twins
#16
Amabile Dario, Manuela Ferreira, Kathryn Refshauge, Alison Harmer, Juan Sánchez-Romera, Francisco Pérez-Riquelme, Ligia Cisneros, Juan Ordoñana, Paulo Ferreira
BACKGROUND: Back pain and type 2 diabetes often co-occur, resulting in greater impact on people's health and complexity in their care. Plausible causal mechanisms for this association have been proposed, yet the nature of the link remains unclear. We therefore explored the direction of the association between type 2 diabetes and chronic back pain in twins, controlling for genetics and early environmental confounding. METHODS: 2,096 and 1,098 twins were included in the cross-sectional and longitudinal analyses, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28368984/degenerative-spondylolisthesis-is-related-to-multiparity-and-hysterectomies-in-older-women
#17
Jacek Cholewicki, Angela S Lee, John M Popovich, Lawrence W Mysliwiec, Michael D Winkelpleck, John N Flood, Pramod K Pathak, Kiilani H Kaaikala, N Peter Reeves, Ralph Kothe
STUDY DESIGN: A case-control study OBJECTIVE.: To determine whether parity and abdominal surgeries are associated with degenerative spondylolisthesis (DS). SUMMARY OF BACKGROUND DATA: DS is considered to be a major cause of low back pain (LBP) in the older population, with greater prevalence of DS among women. Because LBP and impaired abdominal muscle function are common during pregnancy and post-partum, parity-related abdominal muscle deficiency, resulting in poor spinal mechanics, could be a factor in the development of DS in women...
March 31, 2017: Spine
https://www.readbyqxmd.com/read/28365848/attenuation-of-cortical-activity-triggering-descending-pain-inhibition-in-chronic-low-back-pain-patients-a-functional-magnetic-resonance-imaging-study
#18
Yohei Matsuo, Jiro Kurata, Miho Sekiguchi, Katsuhiro Yoshida, Takuya Nikaido, Shin-Ichi Konno
PURPOSE: A considerable portion of chronic low back pain (cLBP) patients lack anatomical abnormality, resist conventional therapeutic interventions, and their symptoms are often complicated with psychological and social factors. Such patients have been reported to show cerebral abnormalities both in anatomy and function by neuroimaging studies. Here we examined differences in cerebral reactivity to a simulated low back pain stimulus between cLBP patients and healthy controls by functional magnetic resonance imaging (fMRI), and their behavioral correlates from a psychophysical questionnaire...
April 1, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28361271/the-development-of-translational-biomarkers-as-a-tool-for-improving-the-understanding-diagnosis-and-treatment-of-chronic-neuropathic-pain
#19
David A Buckley, Elaine M Jennings, Nikita N Burke, Michelle Roche, Veronica McInerney, Jonathan D Wren, David P Finn, Patrick C McHugh
Chronic neuropathic pain (CNP) is one of the most significant unmet clinical needs in modern medicine. Alongside the lack of effective treatments, there is a great deficit in the availability of objective diagnostic methods to reliably facilitate an accurate diagnosis. We therefore aimed to determine the feasibility of a simple diagnostic test by analysing differentially expressed genes in the blood of patients diagnosed with CNP of the lower back and compared to healthy human controls. Refinement of microarray expression data was performed using correlation analysis with 3900 human 2-colour microarray experiments...
March 30, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28350945/intervertebral-disk-degeneration-and-repair
#20
James Dowdell, Mark Erwin, Theodoe Choma, Alexander Vaccaro, James Iatridis, Samuel K Cho
Intervertebral disk (IVD) degeneration is a natural progression of the aging process. Degenerative disk disease (DDD) is a pathologic condition associated with IVD that has been associated with chronic back pain. There are a variety of different mechanisms of DDD (genetic, mechanical, exposure). Each of these pathways leads to a final common result of unbalancing the anabolic and catabolic environment of the extracellular matrix in favor of catabolism. Attempts have been made to gain an understanding of the process of IVD degeneration with in Vitro studies...
March 1, 2017: Neurosurgery
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