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Mechanical back pain

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https://www.readbyqxmd.com/read/29150945/development-of-an-in-vivo-mouse-model-of-discogenic-low-back-pain
#1
Changgui Shi, Vaskar Das, Xin Li, Ranjan Kc, Sujun Qiu, InSug O-Sullivan, Richard L Ripper, Jeffrey S Kroin, Fackson Mwale, Atiyayein A Wallace, Bingqian Zhu, Lan Zhao, Andre J van Wijnen, Mingliang Ji, Jun Lu, Gina Votta-Velis, Wen Yuan, Hee-Jeong Im
Discogenic Low back pain (DLBP) is extremely common and costly. Effective treatments are lacking due to DLBP's unknown pathogenesis. Currently, there are no in vivo mouse models of DLBP, which restricts research in this field. The aim of this study was to establish a reliable DLBP model in mouse that captures the pathological changes in the disc and allows longitudinal pain testing. The model was generated by puncturing the mouse lumbar discs (L4/5, L5/6, and L6/S1) and removing the nucleus pulposus using a microscalpel under the microscope...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29143122/vitamin-d-supplementation-attenuates-oxidative-stress-in-paraspinal-skeletal-muscles-in-patients-with-low-back-pain
#2
Katarzyna Dzik, Wojciech Skrobot, Damian Jozef Flis, Mateusz Karnia, Witold Libionka, Wojciech Kloc, Jan Jacek Kaczor
PURPOSE: The aim of the study was to evaluate markers of oxidative stress and vitamin D receptor in paraspinal muscles in low back pain patients with vitamin D deficiency, with normal level of vitamin D, and after 5 weeks of vitamin D supplementation. METHODS: Patients were divided into three groups: supplemented (SUP) with vitamin D, placebo with normal concentration of vitamin D (SUF), and the placebo group with vitamin D deficiency (DEF). The concentration of serum vitamin D was measured before and after the supplementation with vitamin D (3200 IU/ day for 5 weeks)...
November 15, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29142637/lateral-lumbar-interbody-fusion-and-in-situ-screw-fixation-for-rostral-adjacent-segment-stenosis-of-the-lumbar-spine
#3
Young Hoon Choi, Shin Won Kwon, Jung Hyeon Moon, Chi Heon Kim, Chun Kee Chung, Sung Bae Park, Won Heo
Objective: The purpose of this study is to describe the detailed surgical technique and short-term clinical and radiological outcomes of lateral lumbar interbody fusion (LLIF) and in situ lateral screw fixation using a conventional minimally invasive screw fixation system (MISF) for revision surgery to treat rostral lumbar adjacent segment disease. Methods: The medical and radiological records were retrospectively reviewed. The surgery was indicated in 10 consecutive patients with rostral adjacent segment stenosis and instability...
November 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29138666/extensive-pyomyositis-of-vastus-muscles
#4
Chong Yau Ong, Jin Lee Lim, Lourdes Ducusin Galang
We report a case study on a patient who presented with low back and thigh pain of one month duration. He was eventually diagnosed with left thigh pyomyositis. Tissue from thigh grew Staphylococcus aureus. With commencement of antibiotics and surgical drainage, patient made recovery despite prolonged hospital stay. The underlying mechanism of the extensive abscess accompanied by lack of systemic symptoms; is related to relative immunocompromised state of having underlying diabetes mellitus.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29107836/using-verbal-instructions-to-influence-lifting-mechanics-does-the-directive-lift-with-your-legs-not-your-back-attenuate-spinal-flexion
#5
Tyson A C Beach, Tatjana Stankovic, Danielle R Carnegie, Rachel Micay, David M Frost
"Use your legs" is commonly perceived as sound advice to prevent lifting-related low-back pain and injuries, but there is limited evidence that this directive attenuates the concomitant biomechanical risk factors. Body segment kinematic data were collected from 12 men and 12 women who performed a laboratory lifting/lowering task after being provided with different verbal instructions. The main finding was that instructing participants to lift "without rounding your lower back" had a greater effect on the amount of spine flexion they exhibited when lifting/lowering than instructing them to lift "with your legs instead of your back" and "bend your knees and hips"...
October 31, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29105941/assessment-and-manifestation-of-central-sensitisation-across-different-chronic-pain-conditions
#6
L Arendt-Nielsen, B Morlion, S Perrot, A Dahan, A Dickenson, H G Kress, C Wells, D Bouhassira, A Mohr Drewes
Different neuroplastic processes can occur along the nociceptive pathways and may be important in the transition from acute to chronic pain and for diagnosis and development of optimal management strategies. The neuroplastic processes may result in gain (sensitisation) or loss (desensitisation) of function in relation to the incoming nociceptive signals. Such processes play important roles in chronic pain, and although the clinical manifestations differ across condition processes, they share some common mechanistic features...
November 5, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29105592/biologic-annulus-fibrosus-repair-a-review-of-preclinical-in-vivo-investigations
#7
Stephen Rogers Sloan, Marianne Lintz, Ibrahim Hussain, Roger Härtl, Lawrence J Bonassar
Lower back pain, the leading cause of workplace absences and disability, is often attributed to intervertebral disc (IVD) degeneration in which nucleus pulposus (NP) herniates through lesions in the annulus fibrosus (AF) and impinges on the spinal cord and surrounding nerves. Surgeons remove extruded NP via discectomy when indicated by local/radicular pain supported by radiographic evidence, however current interventions do not alter the underlying disease or seal the AF. The reported rates of recurrent herniation or pain following discectomy cases range from 5-25%, which has pushed spine research in recent years towards annular repair and closure strategies...
November 4, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29105244/spinal-cord-stimulation-for-treating-chronic-pain-reviewing-preclinical-and-clinical-data-on-paresthesia-free-high-frequency-therapy
#8
REVIEW
Krishnan Chakravarthy, Hira Richter, Paul J Christo, Kayode Williams, Yun Guan
BACKGROUND: Traditional spinal cord stimulation (SCS) requires that paresthesia overlaps chronic painful areas. However, the new paradigm high-frequency SCS (HF-SCS) does not rely on paresthesia. STUDY DESIGN: A review of preclinical and clinical studies regarding the use of paresthesia-free HF-SCS for various chronic pain states. METHODS: We reviewed available literatures on HF-SCS, including Nevro's paresthesia-free ultra high-frequency 10 kHz therapy (HF10-SCS)...
November 3, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29105105/low-back-pain-due-to-superior-cluneal-nerve-entrapment-clinicopathological-study
#9
Kyongsong Kim, Jun Shimizu, Toyohiko Isu, Kiyoharu Inoue, Yasuhiro Chiba, Naotaka Iwamoto, Daijiro Morimoto, Masanori Isobe, Akio Morita
INTRODUCTION: We studied the clinical and nerve pathological features in 6 patients whose low back pain (LBP) was relieved by superior cluneal nerve (SCN) neurectomy to determine whether nerve compression was the mechanism underlying this type of LBP. METHODS: ALL 6 patients (7 nerves) underwent SCN neurectomy for intractable LBP. Their clinical outcomes and the pathological features of 7 nerves were reviewed. RESULTS: All patients reported LBP relief immediately after SCN neurectomy...
November 3, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29103550/causal-mechanisms-in-the-clinical-course-and-treatment-of-back-pain
#10
REVIEW
H Lee, G Mansell, J H McAuley, S J Kamper, M Hübscher, G L Moseley, L Wolfenden, R K Hodder, C M Williams
In recent years, there has been increasing interest in studying causal mechanisms in the development and treatment of back pain. The aim of this article is to provide an overview of our current understanding of causal mechanisms in the field. In the first section, we introduce key concepts and terminology. In the second section, we provide a brief synopsis of systematic reviews of mechanism studies relevant to the clinical course and treatment of back pain. In the third section, we reflect on the findings of our review to explain how understanding causal mechanisms can inform clinical practice and the implementation of best practice...
December 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29097955/thoracic-schwannoma-in-an-adult-male-presenting-with-thoracic-pain-a-case-report
#11
Andrew M Rodgers, Kim B Khauv
Objective: The purpose of this case report was to describe a patient presenting with back pain subsequently diagnosed with thoracic schwannoma. Clinical Features: A 45-year-old male presented to a chiropractic practice with mid-back, low back, and sacroiliac pain. Orthopedic examination revealed joint dysfunction in the thoracic-sacroiliac region with normal findings on neurologic examination. An initial diagnosis of thoracic spinal pain and sacroiliac sprain and strain was made...
September 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29097953/a-young-female-athlete-with-acute-low-back-pain-caused-by-stage-iv-breast-cancer
#12
Evan A Kahn
Objective: The purpose of this case report is to describe the case of a young female athlete with low back pain caused by metastatic breast cancer. Clinical Features: A 27-year-old woman presented with low back pain after striking a ball during kickball 3 days earlier. Because of the mechanism of injury and onset, the patient was originally diagnosed with a lumbar spine sprain/strain. Intervention/Outcome: After radiographs were obtained and were read as unremarkable, a 2-week trial of care was initiated that included soft-tissue mobilizations, anti-inflammatory medications from her primary care physician, and therapeutic rehabilitation exercises...
September 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29097271/the-effects-of-an-8-week-stabilization-exercise-program-on-lumbar-multifidus-muscle-thickness-and-activation-as-measured-with-ultrasound-imaging-in-patients-with-low-back-pain-an-exploratory-study
#13
Christian Larivière, Dany H Gagnon, Sharon M Henry, Richard Preuss, Jean-Pierre Dumas
BACKGROUND: Lumbar statilization exercise programs (LSEP) produce positive effects on clinical outcomes, but the underlying mechanisms remain fairly unexplored. Psychological and neuromuscular mechanisms can be involved such as a better activation of the lumbar multifidus which represents one possibility. OBJECTIVES: To determine the (1) effect of a LSEP on lumbar multifidus muscle thickness and activation, as measured with rehabilitative ultrasound imaging (RUSI), in patients with low back pain (LBP); (2) correlation between RUSI measures and any change in clinical outcomes following the LSEP; (3) reliability of RUSI measures in control subjects over 8 weeks...
October 30, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29095376/circulating-lipids-and-acute-pain-sensitization-an-exploratory-analysis
#14
Angela Starkweather, Thomas Julian, Divya Ramesh, Amy Heineman, Jamie Sturgill, Susan G Dorsey, Debra E Lyon, Dayanjan Shanaka Wijesinghe
BACKGROUND: In individuals with low back pain, higher lipid levels have been documented and were associated with increased risk for chronic low back pain. OBJECTIVES: The purpose of this research was to identify plasma lipids that discriminate participants with acute low back pain with or without pain sensitization as measured by quantitative sensory testing. METHODS: This exploratory study was conducted as part of a larger parent randomized controlled trial...
November 2017: Nursing Research
https://www.readbyqxmd.com/read/29091881/phytochemical-profile-and-mechanisms-involved-in-the-anti-nociception-caused-by-the-hydroethanolic-extract-obtained-from-tocoyena-formosa-cham-schltdl-k-schum-jenipapo-bravo-leaves-in-mice
#15
Francisco Rafael Alves Santana Cesário, Thaís Rodrigues de Albuquerque, Giovana Mendes de Lacerda, Maria Rayane Correia de Oliveira, Lindaiane Bezerra Rodrigues, Anita Oliveira Brito Pereira Bezerra Martins, Aline Augusti Boligon, Lucindo José Quintans Júnior, Adriano Antunes de Souza Araújo, Mariana Lima Vale, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes
Tocoyena formosa, a small ornamental tree growing in the dry regions of central Brazil, is commonly known as 'genipapo do bravo'. This is a medicinal plant traditionally used as an analgesic for rheumatic pain, lower back pain and myalgia, however its use is carried out without scientific evidence, which thus justifies the development of studies to investigate and prove its therapeutic potential. Therefore, the objective of this study was to evaluate the phytochemical profile of Tocoyena formosa (Cham. & Schlecht...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29089923/sensory-alterations-in-patients-with-isolated-idiopathic-dystonia-an-exploratory-quantitative-sensory-testing-analysis
#16
Lejla Paracka, Florian Wegner, Christian Blahak, Mahmoud Abdallat, Assel Saryyeva, Dirk Dressler, Matthias Karst, Joachim K Krauss
Abnormalities in the somatosensory system are increasingly being recognized in patients with dystonia. The aim of this study was to investigate whether sensory abnormalities are confined to the dystonic body segments or whether there is a wider involvement in patients with idiopathic dystonia. For this purpose, we recruited 20 patients, 8 had generalized, 5 had segmental dystonia with upper extremity involvement, and 7 had cervical dystonia. In total, there were 13 patients with upper extremity involvement...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29080714/hippocampal-morphology-mediates-biased-memories-of-chronic-pain
#17
Sara E Berger, Étienne Vachon-Presseau, Taha B Abdullah, Alex T Baria, Thomas J Schnitzer, A Vania Apkarian
Experiences and memories are often mismatched. While multiple studies have investigated psychological underpinnings of recall error with respect to emotional events, the neurobiological mechanisms underlying the divergence between experiences and memories remain relatively unexplored in the domain of chronic pain. Here we examined the discrepancy between experienced chronic low back pain (CBP) intensity (twice daily ratings) and remembered pain intensity (n = 48 subjects) relative to psychometric properties, hippocampus morphology, memory capabilities, and personality traits related to reward...
November 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/29067082/effectiveness-of-core-stabilization-exercises-and-routine-exercise-therapy-in-management-of-pain-in-chronic-non-specific-low-back-pain-a-randomized-controlled-clinical-trial
#18
Muhammad Waseem Akhtar, Hossein Karimi, Syed Amir Gilani
BACKGROUND & OBJECTIVE: Low back pain is a frequent problem faced by the majority of people at some point in their lifetime. Exercise therapy has been advocated an effective treatment for chronic low back pain. However, there is lack of consensus on the best exercise treatment and numerous studies are underway. Conclusive studies are lacking especially in this part of the world. Thisstudy was designed to compare the effectiveness of specific stabilization exercises with routine physical therapy exerciseprovided in patients with nonspecific chronic mechanical low back pain...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29054609/estimating-the-l5s1-flexion-extension-moment-in-symmetrical-lifting-using-a-simplified-ambulatory-measurement-system
#19
Axel S Koopman, Idsart Kingma, Gert S Faber, Jonas Bornmann, Jaap H van Dieën
Mechanical loading of the spine has been shown to be an important risk factor for the development of low-back pain. Inertial motion capture (IMC) systems might allow measuring lumbar moments in realistic working conditions, and thus support evaluation of measures to reduce mechanical loading. As the number of sensors limits applicability, the objective of this study was to investigate the effect of the number of sensors on estimates of L5S1 moments. Hand forces, ground reaction forces (GRF) and full-body kinematics were measured using a gold standard (GS) laboratory setup...
October 12, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29053719/total-disc-replacement-using-tissue-engineered-intervertebral-discs-in-the-canine-cervical-spine
#20
Yu Moriguchi, Jorge Mojica-Santiago, Peter Grunert, Brenton Pennicooke, Connor Berlin, Thamina Khair, Rodrigo Navarro-Ramirez, Rodolfo J Ricart Arbona, Joseph Nguyen, Roger Härtl, Lawrence J Bonassar
The most common reason that adults in the United States see their physician is lower back or neck pain secondary to degenerative disc disease. To date, approaches to treat degenerative disc disease are confined to purely mechanical devices designed to either eliminate or enable flexibility of the diseased motion segment. Tissue engineered intervertebral discs (TE-IVDs) have been proposed as an alternative approach and have shown promise in replacing native IVD in the rodent tail spine. Here we demonstrate the efficacy of our TE-IVDs in the canine cervical spine...
2017: PloS One
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