keyword
https://read.qxmd.com/read/38531826/epidemiology-of-spondylolisthesis-a-nationwide-study-from-2001-to-2016-in-the-italian-population
#1
JOURNAL ARTICLE
Umile Giuseppe Longo, Sergio De Salvatore, Luca Denaro, Alessandro Mazzola, Ilaria Piergentili, Vincenzo Denaro
STUDY DESIGN: Epidemiological study. OBJECTIVE: This study aimed to evaluate the annual incidence of spondylolisthesis requiring surgery in Italy and the epidemiological characteristics of the patients. BACKGROUND: The health care system continues to incur considerable costs as a result of low-back pain. Segmental instability of the lumbar spine has attracted significant interest from researchers as a potential mechanism leading to mechanical low back pain...
March 27, 2024: Clinical Spine Surgery
https://read.qxmd.com/read/38529366/the-alterations-in-the-brain-corresponding-to-low-back-pain-recent-insights-and-advances
#2
REVIEW
Xuyang Li, Fancheng Meng, Wenye Huang, Yue Cui, Fanbo Meng, Shengxi Wu, Hui Xu
Low back pain (LBP) is a leading cause of global disabilities. Numerous molecular, cellular, and anatomical factors are implicated in LBP. Current issues regarding neurologic alterations in LBP have focused on the reorganization of peripheral nerve and spinal cord, but neural mechanisms of exactly what LBP impacts on the brain required further researches. Based on existing clinical studies that chronic pain problems were accompanying alterations in brain structures and functions, researchers proposed logical conjectures that similar alterations occur in LBP patients as well...
2024: Neural Plasticity
https://read.qxmd.com/read/38525510/an-investigation-into-the-frequency-and-risk-factors-of-low-back-pain-following-surgical-treatment-of-isolated-calcaneal-fractures
#3
JOURNAL ARTICLE
Dilek Bayraktar, Cengizhan Özgürbüz, Anıl Murat Öztürk, Salih Kemal Aktuğlu, Nadir Özkayın
OBJECTIVE: This study aimed to determine the frequency of low back pain after calcaneal fractures treated with open reduction internal fixation (ORIF) and the risk factors that cause this condition. METHODS: Thirty-one patients (27 males and 4 females) who underwent surgery for a unilateral calcaneal fracture between 2016 and 2020 and had no complaints of low back pain before fracture surgery were included in the study. The patients were divided into 2 groups: those who developed low back pain after the operation and those who did not...
January 2024: Acta Orthopaedica et Traumatologica Turcica
https://read.qxmd.com/read/38524141/revisiting-roles-of-mast-cells-and-neural-cells-in-keloid-exploring-their-connection-to-disease-activity
#4
JOURNAL ARTICLE
Eunhye Yeo, Joonho Shim, Se Jin Oh, YoungHwan Choi, Hyungrye Noh, Heeyeon Kim, Ji-Hye Park, Kyeong-Tae Lee, Seok-Hyung Kim, Dongyoun Lee, Jong Hee Lee
BACKGROUND: Mast cells (MCs) and neural cells (NCs) are important in a keloid microenvironment. They might contribute to fibrosis and pain sensation within the keloid. However, their involvement in pathological excessive scarring has not been adequately explored. OBJECTIVES: To elucidate roles of MCs and NCs in keloid pathogenesis and their correlation with disease activity. METHODS: Keloid samples from chest and back regions were analyzed...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38523830/a-saudi-woman-with-ceftriaxone-induced-fixed-drug-eruption
#5
Rehab Y Al-Ansari, Leena Abdulrahman Almuhaish, Khaled Abdullah Hassan, Tawasoul Fadoul, Alexander Woodman
BACKGROUND: A fixed drug eruption (FDE) is an immunological cutaneous adverse reaction, classified as a cutaneous adverse drug reaction (CADR) and characterized by well-defined lichenoid lesions that occur at the same site each time. Ceftriaxone is a third-generation antibiotic of cephalosporin antibiotics of the beta-lactam antibiotic family, which has typical in vitro activity against many Gram-negative aerobic bacteria. This is the first clinical case from Saudi Arabia and the fifth in the world to document a woman's experience with recurrent FDE after repeated ceftriaxone use...
2024: Case Reports in Dermatological Medicine
https://read.qxmd.com/read/38518595/inhibition-of-magl-attenuates-intervertebral-disc-degeneration-by-delaying-nucleus-pulposus-senescence-through-sting
#6
JOURNAL ARTICLE
Chunyang Fan, Jiacheng Du, Zilin Yu, Jiale Wang, Lingye Yao, Zhongwei Ji, Wei He, Yongkang Deng, Dechun Geng, Xiexing Wu, Haiqing Mao
Intervertebral disc degeneration (IVDD) stands as the primary cause of low back pain (LBP). A significant contributor to IVDD is nucleus pulposus cell (NPC) senescence. However, the precise mechanisms underlying NPC senescence remain unclear. Monoacylglycerol lipase (MAGL) serves as the primary enzyme responsible for the hydrolysis of 2-arachidonoylglycerol (2-AG), breaking down monoglycerides into glycerol and fatty acids. It plays a crucial role in various pathological processes, including pain, inflammation, and oxidative stress...
March 21, 2024: International Immunopharmacology
https://read.qxmd.com/read/38516315/research-on-the-multidimensional-brain-remodeling-mechanisms-at-the-level-of-brain-regions-circuits-and-networks-in-patients-with-chronic-lower-back-pain-caused-by-lumbar-disk-herniation
#7
JOURNAL ARTICLE
Yuan-Dong Mei, Hang Gao, Wei-Fei Chen, Wei Zhu, Chen Gu, Jun-Peng Zhang, Ji-Ming Tao, Xu-Yun Hua
INTRODUCTION: Chronic lower back pain (cLBP), frequently attributed to lumbar disk herniation (LDH), imposes substantial limitations on daily activities. Despite its prevalence, the neural mechanisms underlying lower back pain remain incompletely elucidated. Functional magnetic resonance imaging (fMRI) emerges as a non-invasive modality extensively employed for investigating neuroplastic changes in neuroscience. In this study, task-based and resting-state fMRI methodologies are employed to probe the central mechanisms of lower back pain...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38512304/the-effect-of-cleat-position-on-foot-pain-in-cyclists
#8
JOURNAL ARTICLE
Mattia Bonfatti, Erik Bizzoni, Alessandro Gennari, Stefano Salvioli
Amateur or non-competitive cycling is one of the most popular and growing sports, and the repetitive nature of this sport, combined with a cleat position that is too far forward, often leads to peripheral ischemia or pressure, which can cause pain at the metatarsal level due to the nerve and vascular structures present at this level, according to several authors. This clinical series describes the work done to reduce pain in 21 cyclists who reported foot pain/discomfort exclusively during pedaling. To exclude different causes of pain, other than the position of the cleat, the cyclists received biomechanical assessments using an indoor bike smart trainer and a 2D motion capture system...
March 21, 2024: Journal of Sports Medicine and Physical Fitness
https://read.qxmd.com/read/38510859/non-secretory-multiple-myeloma-a-new-observation-and-review-of-the-literature
#9
Zohra Ouzzif, Yassine Eddair, Wissal Laassara, Hicham El Maaroufi, El Mehdi Mahtat
Non-secreting multiple myeloma is a rare variant of multiple myeloma that affects a relatively young population. It is characterized by the non-secretory nature of malignant plasma cells. The following case report describes the history of a 54-year-old patient with non-secretory myeloma revealed by mechanical and inflammatory low back pain. The bone and neurological involvement, the presence of diffuse osteolytic lesions and the increase in the serum kappa free light chains (FLC) level prompted a myelogram...
February 2024: Curēus
https://read.qxmd.com/read/38510562/dry-needling-with-the-use-of-frsc-technique-in-addition-to-standard-rehabilitation-program-for-chronic-low-back-pain-a-randomized-controlled-trial-using-both-proms-and-measurement-tools
#10
Joanna Rajfur, Katarzyna Rajfur, Tomasz Matusz, Maria Malarska, Karolina Walewicz, Kuba Ptaszkowski, Robert Dymarek, Jakub Taradaj
PURPOSE: Dry needling (DN) has gained popularity for musculoskeletal conditions, but its commercial use often surpasses scientific evidence. The novel Five Regulatory Systems Concept (FRSc) of DN shows potential therapeutic mechanisms, including chronic low back pain (LBP). However, rigorous clinical assessment with patient-reported outcome measures (PROMs) and objective measures are necessary. This study aimed to evaluate the effect of DN according to pain levels, postural control and selected gait parameters in patients with chronic LBP...
2024: Journal of Pain Research
https://read.qxmd.com/read/38506681/pulsed-radiofrequency-therapy-at-different-voltages-on-dorsal-root-ganglia-using-multifunctional-catheter-to-treat-low-back-pain-a-comparative-retrospective-study
#11
JOURNAL ARTICLE
Dolores Rufolo, Carmelo Attilio Costa, Giulia Bravo, Paola Nosella
BACKGROUND: Applying pulsed radiofrequency (PRF) to the dorsal root ganglion (DRG) is an electrical neuromodulation technique, a valid complementary therapeutic treatment for failed back surgery syndrome (FBBS). Peridurolysis, when applied to vertebral canal adhesions, can be performed with dedicated catheters, providing patients with the benefits of mechanical, electrical, and pharmacological techniques. OBJECTIVES: The aim of this study was to evaluate PRF's effects on the DRG as part of FBSS treatment at different follow-up times, comparing 2 groups of patients exposed to distinct levels of voltage (100 V vs...
March 2024: Pain Physician
https://read.qxmd.com/read/38504579/glutamine-mitigates-oxidative-stress-induced-matrix-degradation-ferroptosis-and-pyroptosis-in-nucleus-pulposus-cells-via-deubiquitinating-and-stabilizing-nrf2
#12
JOURNAL ARTICLE
Jiajun Wu, Weitao Han, Yangyang Zhang, Shuangxing Li, Tianyu Qin, Zhengqi Huang, Chao Zhang, Ming Shi, Yuliang Wu, Wanli Zheng, Bo Gao, Kang Xu, Wei Ye
AIMS: Intervertebral disc degeneration (IDD) is closely related to low back pain (LBP), which is a prevalent age-related problem worldwide; however, the mechanism underlying IDD is unknown. Glutamine, a free amino acid prevalent in plasma, is recognized for its anti-inflammatory and antioxidant properties in various diseases, the current study aims to clarify the effect and mechanism of glutamine in IDD. RESULTS: A synergistic interplay was observed between pyroptosis and ferroptosis within degenerated human disc specimens...
March 19, 2024: Antioxidants & Redox Signaling
https://read.qxmd.com/read/38496129/effects-of-movement-retraining-and-lumbar-stabilization-exercises-in-mechanical-low-back-pain-a-pilot-study
#13
JOURNAL ARTICLE
Roopa Desai, Manisha Rathi, Tushar J Palekar
Objective To determine and compare the effects of movement retraining (MR), lumbar stabilization exercises (LSE), and a combination of both these exercises on pain, flexibility, strength, and functional disability in chronic mechanical low back pain (CMLBP) patients. Materials and methods Fifteen CMLBP participants, aged 20-40 years, were randomly allocated into three groups. Group A (n=5) received MR, group B (n=5), LSE, and group C (n=5), a combination of MR and CSE, along with hot packs for eight weeks, thrice a week on alternate days...
February 2024: Curēus
https://read.qxmd.com/read/38490687/neurophysiological-outcomes-that-sustained-clinically-significant-improvements-over-3-years-of-physiologic-ecap-controlled-closed-loop-spinal-cord-stimulation-for-the-treatment-of-chronic-pain
#14
JOURNAL ARTICLE
Nagy A Mekhail, Robert M Levy, Timothy R Deer, Leonardo Kapural, Sean Li, Kasra Amirdelfan, Corey W Hunter, Steven M Rosen, Shrif J Costandi, Steven M Falowski, Abram H Burgher, Jason E Pope, Christopher A Gilmore, Farooq A Qureshi, Peter S Staats, James Scowcroft, Tory McJunkin, Christopher K Kim, Michael I Yang, Thomas Stauss, Richard Rauck, Rui V Duarte, Nicole Soliday, Angela Leitner, Erin Hanson, Zhonghua Ouyang, Dave Mugan, Lawrence Poree
INTRODUCTION: A novel, spinal cord stimulation (SCS) system with a physiologic closed-loop (CL) feedback mechanism controlled by evoked compound action potentials (ECAPs) enables the optimization of physiologic neural dose and the accuracy of the stimulation, not possible with any other commercially available SCS systems. The report of objective spinal cord measurements is essential to increase the transparency and reproducibility of SCS therapy. Here, we report a cohort of the EVOKE double-blind randomized controlled trial treated with CL-SCS for 36 months to evaluate the ECAP dose and accuracy that sustained the durability of clinical improvements...
March 15, 2024: Regional Anesthesia and Pain Medicine
https://read.qxmd.com/read/38488012/disassembly-of-the-trim56-atr-complex-promotes-cytodna-cgas-sting-axis-dependent-intervertebral-disc-inflammatory-degeneration
#15
JOURNAL ARTICLE
Weifeng Zhang, Gaocai Li, Xingyu Zhou, Huaizhen Liang, Bide Tong, Di Wu, Kevin Yang, Yu Song, Bingjin Wang, Zhiwei Liao, Liang Ma, Wencan Ke, Xiaoguang Zhang, Jie Lei, Chunchi Lei, Xiaobo Feng, Kun Wang, Kangcheng Zhao, Cao Yang
As the leading cause of disability worldwide, low back pain (LBP) is recognized as a pivotal socioeconomic challenge to the aging population and is largely attributed to intervertebral disc degeneration (IVDD). Elastic nucleus pulposus (NP) tissue is essential for the maintenance of IVD structural and functional integrity. The accumulation of senescent NP cells with an inflammatory hypersecretory phenotype due to aging and other damaging factors is a distinctive hallmark of IVDD initiation and progression. In this study, we reveal a mechanism of IVDD progression in which aberrant genomic DNA damage promoted NP cell inflammatory senescence via activation of the cyclic GMP-AMP synthase/stimulator of IFN genes (cGAS/STING) axis but not of absent in melanoma 2 (AIM2) inflammasome assembly...
January 23, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38484855/preliminary-characterization-of-age-and-chronic-low-back-pain-effects-on-multimodal-pain-sensitivity-a-comparison-study-in-older-adults-with-and-without-chronic-low-back-pain
#16
JOURNAL ARTICLE
Patrick J Knox, Corey B Simon, Gregory E Hicks
Though pain sensitivity impairments contribute to chronic pain in younger adults, it is unclear if pain hypersensitivity manifests with aging and is heightened in the geriatric chronic low back pain (CLBP) population. The cross-sectional study preliminarily addressed this gap by measuring pain sensitivity in older adults with CLBP (n=25) as well as pain-free sex-matched older (n=25) and younger adults (n=25). Pain sensitivity was quantified by 8 distinct measures that were subdivided as static (i.e., pressure pain thresholds, heat pain thresholds, fixed mechanical pain, and fixed cold pain) and dynamic pain sensitivity (i...
March 12, 2024: Journal of Pain
https://read.qxmd.com/read/38484462/the-sanbi-decoction-alleviates-intervertebral-disc-degeneration-in-rats-through-intestinal-flora-and-serum-metabolic-homeostasis-modulation
#17
JOURNAL ARTICLE
Nan Wang, Shuang Chen, Yimin Xie, Xin Liu, Zhipeng Xi, Jingchi Li, Congyang Xue, Rongrong Deng, Wen Min, Ran Kang, Lin Xie
BACKGROUND: Intervertebral disc degeneration (IVDD) is an essential cause of low back pain (LBP), the incidence of which has risen in recent years and is progressively younger, but treatment options are limited, placing a serious economic burden on society. Sanbi decoction (SBD) is an important classical formula for the treatment of IVDD, which can significantly improve patients' symptoms and is a promising alternative therapy. PURPOSE: The aim of this study is to investigate the safety and efficacy of SBD in the treatment of IVDD and to explore the underlying mechanisms by using an integrated analytical approach of microbiomics and serum metabolomics, as well as by using molecular biology...
February 24, 2024: Phytomedicine
https://read.qxmd.com/read/38483469/testing-biological-and-psychological-pathways-of-emotion-regulation-as-a-primary-mechanism-of-action-in-yoga-interventions-for-chronic-low-back-pain-protocol-for-a-randomized-controlled-trial
#18
JOURNAL ARTICLE
Angela R Starkweather, Wanli Xu, Katherine E Gnall, Mariel Emrich, Camille L Garnsey, Zachary E Magin, Weizi Wu, Joseph Fetta, Erik J Groessl, Crystal Park
BACKGROUND: Interventions that promote adaptive emotion regulation (ER) skills reduce pain in patients with chronic pain; however, whether the effects of yoga practice on chronic low back pain (CLBP) are due to improvements in ER remains to be examined. OBJECTIVE: This study will test whether the effects of yoga on CLBP (improved pain severity and interference) are mediated by improved ER, the extent to which effects are related to specific aspects of ER, and the role of pain sensitization as a mediator or moderator of effects...
March 14, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38483366/five-year-longitudinal-follow-up-of-restorative-neurostimulation-shows-durability-of-effectiveness-in-patients-with-refractory-chronic-low-back-pain-associated-with-multifidus-muscle-dysfunction
#19
JOURNAL ARTICLE
Christopher Gilligan, Willem Volschenk, Marc Russo, Matthew Green, Christopher Gilmore, Vivek Mehta, Kristiaan Deckers, Kris De Smedt, Usman Latif, Dawood Sayed, Peter Georgius, Jonathan Gentile, Bruce Mitchell, Meredith Langhorst, Frank Huygen, Ganesan Baranidharan, Vikas Patel, Eugene Mironer, Edgar Ross, Alexios Carayannopoulos, Salim Hayek, Ashish Gulve, Jean-Pierre Van Buyten, Antoine Tohmeh, Jeffrey Fischgrund, Shivanand Lad, Farshad Ahadian, Timothy Deer, William Klemme, Richard Rauck, James Rathmell, Greg Maislin, Jan Pieter Heemels, Sam Eldabe
BACKGROUND: Adults with refractory, mechanical chronic low back pain associated with impaired neuromuscular control of the lumbar multifidus muscle have few treatment options that provide long-term clinical benefit. This study hypothesized that restorative neurostimulation, a rehabilitative treatment that activates the lumbar multifidus muscles to overcome underlying dysfunction, is safe and provides relevant and durable clinical benefit to patients with this specific etiology. MATERIALS AND METHODS: In this prospective five-year longitudinal follow-up of the ReActiv8-B pivotal trial, participants (N = 204) had activity-limiting, moderate-to-severe, refractory, mechanical chronic low back pain, a positive prone instability test result indicating impaired multifidus muscle control, and no indications for spine surgery...
March 11, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38481170/calcitonin-receptor-calcitonin-gene-related-peptide-and-amylin-distribution-in-c1-2-dorsal-root-ganglia
#20
JOURNAL ARTICLE
Tayla A Rees, Zoe Tasma, Michael L Garelja, Simon J O'Carroll, Christopher S Walker, Debbie L Hay
BACKGROUND: The upper cervical dorsal root ganglia (DRG) are important for the transmission of sensory information associated with the back of the head and neck, contributing to head pain. Calcitonin receptor (CTR)-based receptors, such as the amylin 1 (AMY1 ) receptor, and ligands, calcitonin gene-related peptide (CGRP) and amylin, have been linked to migraine and pain. However, the contribution of this system to nociception involving the cervical DRG is unclear. Therefore, this study aimed to determine the relative distribution of the CTR, CGRP, and amylin in upper cervical DRG...
March 14, 2024: Journal of Headache and Pain
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