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acetaminophen, chronic pain

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https://www.readbyqxmd.com/read/27904731/clinical-usefulness-of-long-term-application-of-fentanyl-matrix-in-chronic-non-cancer-pain-improvement-of-pain-and-physical-and-emotional-functions
#1
Jaewon Lee, Joon Shik Yoon, Jae Hyup Lee, So-Hak Chung, Kyu-Yeol Lee, Young Yul Kim, Jong Moon Kim, Min Ho Kong, Ung Gu Kang, Ye-Soo Park
BACKGROUND: Opioids are recently recommended for those who do not gain adequate pain relief from the use of acetaminophen or nonsteroidal anti-inflammatory drugs. Medical opioids are administered in various routes, and transdermal opioid products that can make up for the weaknesses of the oral or intravenous products have been developed. This study is to evaluate the clinical usefulness of fentanyl matrix in terms of the long-term improvement in pain and physical and mental functions...
December 2016: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/27893572/pain-management-in-pediatric-burn-patients-review-of-recent-literature-and-future-directions
#2
Omar Pardesi, Gennadiy Fuzaylov
Childhood burns are a profoundly traumatic and painful experience. Despite recognition of the prevalence of burn injuries in children and the severity of the associated pain, burn pain remains undertreated. At the same time, more evidence is emerging to suggest that undertreated pain has serious long-term medical and psychiatric consequences, many of which can be ameliorated with improved pain control. Pain in burn patients is, however, notoriously difficult to treat, perhaps because there is a chronic pain aspect underlying the acute pain that accompanies wound care and procedures...
November 17, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27836577/chronic-use-of-opioids-before-and-after-total-knee-arthroplasty-a-retrospective-cohort-study
#3
Craig A Hansen, Maria C S Inacio, Nicole L Pratt, Elizabeth E Roughead, Stephen E Graves
BACKGROUND: Opioids are commonly used for the management of preoperative and postoperative pain among patients undergoing total knee arthroplasty (TKA). There is limited literature on the chronic use of opioids pre-TKA and post-TKA. The aim of this study was to characterize the use of opioids in TKA patients before and after surgery and identify risk factors of chronic opioid use. METHODS: Opioid use among 15,020 patients undergoing TKA (01/01/2001-31/12/2012) was examined...
October 4, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27829018/paravertebral-block-plus-thoracic-wall-block-versus-paravertebral-block-alone-for-analgesia-of-modified-radical-mastectomy-a-retrospective-cohort-study
#4
Nai-Liang Li, Ben-Long Yu, Chen-Fang Hung
BACKGROUND AND OBJECTIVES: Paravertebral block placement was the main anesthetic technique for modified radical mastectomy in our hospital until February 2014, when its combination with blocks targeting the pectoral musculature was initiated. We compared the analgesic effects of paravertebral blocks with or without blocks targeting the pectoral musculature for modified radical mastectomy. METHODS: We retrospectively collected data from a single surgeon and anesthesiologist from June 1, 2012, to May 31, 2015...
2016: PloS One
https://www.readbyqxmd.com/read/27741965/pharmacotherapies-in-geriatric-chronic-pain-management
#5
REVIEW
Zachary A Marcum, Nakia A Duncan, Una E Makris
Pharmacologic management of chronic pain in older adults is one component of the multimodal, interdisciplinary management of this complex condition. In this article, we summarize several of the key barriers to effective pharmacologic management in older adults and review the existing (albeit limited) evidence for its effectiveness and safety, especially in a medically complex population with multimorbidity. This review covers topical formulations, acetaminophen, oral nonsteroidal antiinflammatory drugs, and adjuvant therapies...
November 2016: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/27698681/pain-control-by-melatonin-physiological-and-pharmacological-effects
#6
Wei-Wei Chen, Xia Zhang, Wen-Juan Huang
Pain and anxiety are the most common neurological responses to many harmful or noxious stimuli and their management clinically is often challenging. Many of the frequently used morphine-based drugs, non-steroid anti-inflammatory drugs and acetaminophen, while efficient for treating pain, lead to patients suffering from several unwanted side effects. Melatonin, produced from the pineal body is a hormone of darkness, is involved in the control of circadian rhythms, and exerts a number of pharmacological effects...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27622918/endometriosis-in-adolescence-practical-rules-for-an-earlier-diagnosis
#7
Letizia Zannoni, Simona Del Forno, Roberto Paradisi, Renato Seracchioli
Dysmenorrhea, cyclic pelvic pain, and acyclic pelvic pain are common in adolescent girls, and at least 10% of these girls are at risk for subsequent development of endometriosis. In this article we highlight practical tips for the management of dysmenorrhea and chronic pelvic pain and how to diagnose endometriosis as early as possible and detect patients at risk for developing the disease in the future. We suggest five practical rules for managing adolescents with dysmenorrhea and chronic pelvic pain: (1) Never underestimate the pain; (2) Always consider endometriosis as a possible cause of severe cyclic pain; (3) Obtain a detailed and accurate history before performing clinical evaluation and pelvic sonography; (4) Treat the pain with hormonal therapies (combined oral contraceptives or progestogen-only pill) and analgesics (acetaminophen and nonsteroidal anti-inflammatory drugs); and (5) Plan frequent follow-up visits to re-evaluate the patient...
September 1, 2016: Pediatric Annals
https://www.readbyqxmd.com/read/27590454/evaluation-of-low-level-laser-at-auriculotherapy-points-to-reduce-postoperative-pain-in-inferior-third-molar-surgery-study-protocol-for-a-randomized-controlled-trial
#8
Hélio Sampaio-Filho, Juliane Sotto-Ramos, Erika Horácio Pinto, Marcia Regina Cabral, Priscila Larcher Longo, Isabel Peixoto Tortamano, Rodrigo Labat Marcos, Daniela Fátima Teixeira Silva, Christine Pavani, Anna Carolina Ratto Tempestini Horliana
BACKGROUND: A comfortable postoperative return to daily activities has increased the need to control inflammation after third molar surgery. Anti-inflammatory drugs and analgesics are not exempt from adverse effects such as allergies and chronic gastritis, and they are not without cost. The association between low-level laser and auricular acupuncture can be an alternative when conventional drugs are contraindicated. Among its advantages, we can mention the low risk of side effects, low cost and simplicity of application...
2016: Trials
https://www.readbyqxmd.com/read/27548493/effects-of-balsamodendron-mukul-gum-resin-extract-on-articular-cartilage-in-papain-induced-osteoarthritis
#9
Jayanand Manjhi, Maneesh Gupta, Anvesha Sinha, Beena Rawat, Durg V Rai
Context • Osteoarthritis (OA) is one of the most prevalent chronic diseases of the musculoskeleton, causing functional disability among older adults. Management of OA includes conventional pharmacological treatments consisting primarily of nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, physiotherapy, and surgical procedures. The medications are not ideal therapeutic agents; NSAIDs in particular can cause serious side effects. Objective • The study was conducted to investigate the effects of Balsamodendron mukul (BDM) gum resin extract on cartilage damage and microstructural changes in the subchondral bone of rats with papain-induced, osteoarthritic knee joints...
July 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/27531573/tramadol-hydrochloride-acetaminophen-combination-versus-non-steroidal-anti-inflammatory-drug-for-the-treatment-of%C3%A2-perioperative-pain-after-total-knee-arthroplasty-a-prospective-randomized-open-label-clinical-trial
#10
Takeshi Mochizuki, Koichiro Yano, Katsunori Ikari, Ryo Hiroshima, Hiromitsu Takaoka, Kosei Kawakami, Naoko Koenuma, Mina Ishibashi, Toshikatsu Shirahata, Shigeki Momohara
BACKGROUND: While many of the commonly used treatments for perioperative pain after total knee arthroplasty (TKA) have been recognized as effective, there is still insufficient evidence for oral medication. In orthopedics, non-steroidal anti-inflammatory drugs (NSAIDs) have been commonly used for perioperative pain; however, serious adverse events have been reported. Conversely, tramadol hydrochloride/acetaminophen combination (TRAM/APAP) therapy has been shown to reduce pain, particularly for chronic pain in Japan...
September 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27521193/chronic-pain-in-neurosurgery
#11
REVIEW
Samuel Grodofsky
This review includes a summary of contemporary theories of pain processing and advocates a multimodal analgesia approach for providing perioperative care. A summary of various medication classes and anesthetic techniques is provided that highlights evidence emerging from neurosurgical literature. This summary covers opioid management, acetaminophen, nonsteroidal antiinflammatories, ketamine, lidocaine, dexmedetomidine, corticosteroids, gabapentin, and regional anesthesia for neurosurgery. At present, there is not enough investigation into these areas to describe best practices for treating or preventing chronic pain in neurosurgery; but providers can identify a wider range of options available to personalize perioperative care strategies...
September 2016: Anesthesiology Clinics
https://www.readbyqxmd.com/read/27445626/effect-of-tramadol-acetaminophen-on-motivation-in-patients-with-chronic-low-back-pain
#12
Tomoko Tetsunaga, Tomonori Tetsunaga, Masato Tanaka, Keiichiro Nishida, Yoshitaka Takei, Toshifumi Ozaki
Background. The contribution of apathy, frequently recognized in individuals with neurodegenerative diseases, to chronic low back pain (LBP) remains unclear. Objectives. To investigate levels of apathy and clinical outcomes in patients with chronic LBP treated with tramadol-acetaminophen. Methods. A retrospective case-control study involving 73 patients with chronic LBP (23 male, 50 female; mean age 71 years) treated with tramadol-acetaminophen (n = 36) and celecoxib (n = 37) was performed. All patients were assessed using the self-reported questionnaires...
2016: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/27387351/duloxetine-and-subacute-pain-after-knee-arthroplasty-when-added-to-a-multimodal-analgesic-regimen-a-randomized-placebo-controlled-triple-blinded-trial
#13
Jacques T YaDeau, Chad M Brummett, David J Mayman, Yi Lin, Enrique A Goytizolo, Douglas E Padgett, Michael M Alexiades, Richard L Kahn, Kethy M Jules-Elysee, Kara G Fields, Amanda K Goon, Yuliya Gadulov, Geoffrey Westrich
BACKGROUND: Duloxetine is effective for chronic musculoskeletal and neuropathic pain, but there are insufficient data to recommend the use of antidepressants for postoperative pain. The authors hypothesized that administration of duloxetine for 15 days would reduce pain with ambulation at 2 weeks after total knee arthroplasty. METHODS: In this triple-blinded, randomized, placebo-controlled trial, patients received either duloxetine or placebo for 15 days, starting from the day of surgery...
September 2016: Anesthesiology
https://www.readbyqxmd.com/read/27386723/diagnosis-and-management-of-vertebral-compression-fractures
#14
Jason McCarthy, Amy Davis
Vertebral compression fractures (VCFs) are the most common complication of osteoporosis, affecting more than 700,000 Americans annually. Fracture risk increases with age, with four in 10 white women older than 50 years experiencing a hip, spine, or vertebral fracture in their lifetime. VCFs can lead to chronic pain, disfigurement, height loss, impaired activities of daily living, increased risk of pressure sores, pneumonia, and psychological distress. Patients with an acute VCF may report abrupt onset of back pain with position changes, coughing, sneezing, or lifting...
July 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27320052/what-are-the-therapeutic-alternatives-to-dextropropoxyphene-in-france-a-prescribers-survey
#15
Frédéric Aubrun, Emilie Chrétien, Laurent Letrilliart, Marine Ginoux, Manon Belhassen, Michel Lanteri-Minet, Eric Van Ganse, Hélène Beloeil
About a year after dextropropoxyphene (DXP) withdrawal from the French market, we conducted a survey among members of the French Society of Anesthesia & Intensive Care Medicine (Sfar) and of the French Society of the Study and Treatment of Pain (SFETD) to identify the indications for which this WHO level II analgesic had been prescribed, the prescriber's feedback following withdrawal, and the substitutive analgesics prescribed. DXP had been prescribed by more than 75% of the 430 anaesthesiologists and 230 pain specialists interviewed, mainly for acute and chronic non-cancer pain of moderate intensity...
June 16, 2016: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/27306653/paracetamol-acetaminophen-for-acute-treatment-of-episodic-tension-type-headache-in-adults
#16
REVIEW
Guy Stephens, Sheena Derry, R Andrew Moore
BACKGROUND: Tension-type headache (TTH) affects about 1 person in 5 worldwide. It is divided into infrequent episodic TTH (fewer than one headache per month), frequent episodic TTH (two to 14 headaches per month), and chronic TTH (15 headache days a month or more). Paracetamol (acetaminophen) is one of a number of analgesics suggested for acute treatment of headaches in frequent episodic TTH. OBJECTIVES: To assess the efficacy and safety of paracetamol for the acute treatment of frequent episodic TTH in adults...
June 16, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27271789/paracetamol-for-low-back-pain
#17
REVIEW
Bruno T Saragiotto, Gustavo C Machado, Manuela L Ferreira, Marina B Pinheiro, Christina Abdel Shaheed, Christopher G Maher
BACKGROUND: Analgesic medication is the most frequently prescribed treatment for low back pain (LBP), of which paracetamol (acetaminophen) is recommended as the first choice medication. However, there is uncertainty about the efficacy of paracetamol for LBP. OBJECTIVES: To investigate the efficacy and safety of paracetamol for non-specific LBP. SEARCH METHODS: We conducted searches on the Cochrane Central Register of Controlled Trials (CENTRAL, which includes the Back and Neck Review Group trials register), MEDLINE, EMBASE, CINAHL, AMED, Web of Science, LILACS, and IPA from their inception to 7 August 2015...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27253690/pharmacokinetic-and-pharmacodynamic-evaluation-of-oxycodone-and-naltrexone-for-the-treatment-of-chronic-lower-back-pain
#18
Mellar P Davis
INTRODUCTION: Chronic low back pain (CLBP) is a common and difficult illness to manage. Some individuals with CLBP have pain processing disorders and are also at risk for opioid abuse, misuse; addiction and diversion. Guidelines have been published to guide management; neuromodulation, exercise, mindfulness-based stress reduction and cognitive behavior therapies among other non-pharmacological reduce the pain of CLBP with minimal toxicity. Pharmacological management includes acetaminophen, NSAIDs and antidepressants, mainly duloxetine...
July 2016: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/27235619/pharmacologic-therapies-in-musculoskeletal-conditions
#19
REVIEW
Melinda S Loveless, Adrielle L Fry
Musculoskeletal conditions are common, and there are many options for pharmacologic therapy. Unfortunately, there is not strong evidence for the use of many of these medications. Acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) are generally first-line medications for most musculoskeletal pain, but there is more evidence these medications are not as safe as once thought. Other analgesic and antispasmodic medications can be effective for acute pain but generally are not as effective for chronic pain...
July 2016: Medical Clinics of North America
https://www.readbyqxmd.com/read/27177598/short-term-androgen-therapy-for-men-treated-regularly-with-opioids-for-chronic-noncancer-pain-time-will-tell
#20
P Y Liu, W Zhang
No abstract text is available yet for this article.
August 2016: Clinical Endocrinology
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