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https://www.readbyqxmd.com/read/28521190/simultaneous-determination-of-bisphenol-a-and-estrogens-in-hair-samples-by-liquid-chromatography-electrospray-tandem-mass-spectrometry
#1
Chaelin Lee, Chong Hyeak Kim, Sunghwan Kim, Sung-Hee Cho
Bisphenol A (BPA), an endocrine disrupter, is widely used to make chemicals for polycarbonate, plastics, beverage containers, epoxy resins, and cash register receipts. BPA is one of the known xenoestrogens, which have weak estrogenic activity and cause obesity, diabetes, breast cancer, and reproductive disorders. Even though the concentration level of metabolomes in hair is usually lower than that in urine and blood, there are several reasons why we chose to use hair samples. First, the sampling procedure of hairs is simple...
May 11, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28520558/data-driven-event-by-event-respiratory-motion-correction-using-tof-pet-list-mode-centroid-of-distribution
#2
Silin Ren, Xiao Jin, Chung Chan, Yiqiang Jian, Tim Mulnix, Chi Liu, Richard E Carson
Data-driven respiratory gating techniques were developed to correct for respiratory motion in PET studies, without the help of external motion tracking systems. Due to the greatly increased image noise in gated reconstructions, it is desirable to develop a data-driven event-by-event respiratory motion correction method. In this study, using the Centroid-of-distribution (COD) algorithm, we established a data-driven event-by-event respiratory motion correction technique using TOF PET list-mode data, and investigated its performance by comparing with an external system-based correction method...
May 18, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28518074/eliciting-and-analyzing-male-mouse-ultrasonic-vocalization-usv-songs
#3
Jonathan Chabout, Joshua Jones-Macopson, Erich D Jarvis
Mice produce ultrasonic vocalizations (USVs) in a variety of social contexts throughout development and adulthood. These USVs are used for mother-pup retrieval(1), juvenile interactions(2), opposite and same sex interactions(3)(,)(4)(,)(5), and territorial interactions(6). For decades, the USVs have been used by investigators as proxies to study neuropsychiatric and developmental or behavioral disorders(7)(,)(8)(,)(9), and more recently to understand mechanisms and evolution of vocal communication among vertebrates(10)...
May 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28514024/historical-review-of-efforts-to-reduce-noise-induced-hearing-loss-in-the-united-states
#4
Madeleine J Kerr, Richard L Neitzel, OiSaeng Hong, Robert T Sataloff
BACKGROUND: Noise-induced hearing loss is a centuries-old problem that is still prevalent in the United States and worldwide. AIM: To describe highlights in the development of hearing loss prevention in the U.S. from World War II to the present. METHODS: Literature review. RESULTS: Approaches to occupational noise-induced hearing loss prevention in the United States over the past seven decades are described using a hierarchy of controls framework and an interdisciplinary perspective...
June 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28508843/acoustic-analysis-of-voice-in-nonlaryngeal-head-and-neck-cancer-patients-post-chemoradiotherapy
#5
Nikhila Radhakrishna, B K Yamini, Amrut Sadashiv Kadam, N Shivashankar, Chendil Vishwanathan, Rajesh Javarappa
BACKGROUND: Concurrent chemoradiotherapy (CCRT) used for definitive management of locally advanced head and neck squamous cell carcinoma (HNSCC) allows organ preservation at the cost of preservation of function. Vocal cords, being within the field of irradiation, undergo acute and chronic changes which adversely impacts the patients' voice. AIMS: To assess the acute changes in the acoustic characteristics of voice post-CCRT in patients with nonlaryngeal HNSCC. MATERIALS AND METHODS: Thirty patients with HNSCC treated with CCRT, a total dose of 66-70 Gy/33-35 fractions at five fractions/week, with weekly cisplatin...
January 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28505846/traveling-waves-and-worms-in-ac-driven-electroconvection-under-external-multiplicative-noise
#6
Jong-Hoon Huh
In the presence of external multiplicative noise, ac-driven electroconvection (EC) in a nematic liquid crystal is investigated. Noise-induced traveling waves (TWs) including localized ones (worms) are found with a typical, stationary wave. Three kinds of TWs are classified by their dynamic features (e.g., noise-intensity-dependent Hopf frequency and space-time map). Moreover, ac frequency-dependent threshold voltages of EC are examined in high noise intensities causing abnormal charge redistribution of the EC cell, and the roles of ac and noise fields with respect to TWs are elucidated in successive pattern evolutions...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28505785/noise-induced-polarization-switching-in-complex-networks
#7
Jan O Haerter, Albert Díaz-Guilera, M Ángeles Serrano
The combination of bistability and noise is ubiquitous in complex systems, from biology to social interactions, and has important implications for their functioning and resilience. Here we use a simple three-state dynamical process, in which nodes go from one pole to another through an intermediate state, to show that noise can induce polarization switching in bistable systems if dynamical correlations are significant. In large, fully connected networks, where dynamical correlations can be neglected, increasing noise yields a collapse of bistability to an unpolarized configuration where the three possible states of the nodes are equally likely...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28505727/multiple-binding-sites-for-transcriptional-repressors-can-produce-regular-bursting-and-enhance-noise-suppression
#8
Iván M Lengyel, Luis G Morelli
Cells may control fluctuations in protein levels by means of negative autoregulation, where transcription factors bind DNA sites to repress their own production. Theoretical studies have assumed a single binding site for the repressor, while in most species it is found that multiple binding sites are arranged in clusters. We study a stochastic description of negative autoregulation with multiple binding sites for the repressor. We find that increasing the number of binding sites induces regular bursting of gene products...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28501744/strategy-for-improved-nh2-detection-in-combustion-environments-using-an-alexandrite-laser
#9
Christian Brackmann, Bo Zhou, Per Samuelsson, Vladimir A Alekseev, Alexander A Konnov, Zhongshan Li, Marcus Aldén
A new scheme for NH2 detection by means of laser-induced fluorescence (LIF) with excitation around wavelength 385nm, accessible using the second harmonic of a solid-state Alexandrite laser, is presented. Detection of NH2 was confirmed by identification of corresponding lines in fluorescence excitation spectra measured in premixed NH3-air flames and on NH2 radicals generated through NH3 photolysis in a nonreactive flow at ambient conditions. Moreover, spectral simulations allow for tentative NH2 line identification...
May 4, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28499413/ranking-metrics-in-gene-set-enrichment-analysis-do-they-matter
#10
Joanna Zyla, Michal Marczyk, January Weiner, Joanna Polanska
BACKGROUND: There exist many methods for describing the complex relation between changes of gene expression in molecular pathways or gene ontologies under different experimental conditions. Among them, Gene Set Enrichment Analysis seems to be one of the most commonly used (over 10,000 citations). An important parameter, which could affect the final result, is the choice of a metric for the ranking of genes. Applying a default ranking metric may lead to poor results. METHODS AND RESULTS: In this work 28 benchmark data sets were used to evaluate the sensitivity and false positive rate of gene set analysis for 16 different ranking metrics including new proposals...
May 12, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28498710/charge-induced-force-noise-on-free-falling-test-masses-results-from-lisa-pathfinder
#11
M Armano, H Audley, G Auger, J T Baird, P Binetruy, M Born, D Bortoluzzi, N Brandt, A Bursi, M Caleno, A Cavalleri, A Cesarini, M Cruise, K Danzmann, M de Deus Silva, I Diepholz, R Dolesi, N Dunbar, L Ferraioli, V Ferroni, E D Fitzsimons, R Flatscher, M Freschi, J Gallegos, C García Marirrodriga, R Gerndt, L Gesa, F Gibert, D Giardini, R Giusteri, C Grimani, J Grzymisch, I Harrison, G Heinzel, M Hewitson, D Hollington, M Hueller, J Huesler, H Inchauspé, O Jennrich, P Jetzer, B Johlander, N Karnesis, B Kaune, C J Killow, N Korsakova, I Lloro, L Liu, J P López-Zaragoza, R Maarschalkerweerd, S Madden, D Mance, V Martín, L Martin-Polo, J Martino, F Martin-Porqueras, I Mateos, P W McNamara, J Mendes, L Mendes, A Moroni, M Nofrarias, S Paczkowski, M Perreur-Lloyd, A Petiteau, P Pivato, E Plagnol, P Prat, U Ragnit, J Ramos-Castro, J Reiche, J A Romera Perez, D I Robertson, H Rozemeijer, F Rivas, G Russano, P Sarra, A Schleicher, J Slutsky, C Sopuerta, T J Sumner, D Texier, J I Thorpe, C Trenkel, D Vetrugno, S Vitale, G Wanner, H Ward, P J Wass, D Wealthy, W J Weber, A Wittchen, C Zanoni, T Ziegler, P Zweifel
We report on electrostatic measurements made on board the European Space Agency mission LISA Pathfinder. Detailed measurements of the charge-induced electrostatic forces exerted on free-falling test masses (TMs) inside the capacitive gravitational reference sensor are the first made in a relevant environment for a space-based gravitational wave detector. Employing a combination of charge control and electric-field compensation, we show that the level of charge-induced acceleration noise on a single TM can be maintained at a level close to 1...
April 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28494956/resolution-of-submillisecond-kinetics-of-multiple-reaction-pathways-for-lactate-dehydrogenase
#12
Michael J Reddish, Robert Callender, R Brian Dyer
Enzymes are known to exhibit conformational flexibility. An important consequence of this flexibility is that the same enzyme reaction can occur via multiple reaction pathways on a reaction landscape. A model enzyme for the study of reaction landscapes is lactate dehydrogenase. We have previously used temperature-jump (T-jump) methods to demonstrate that the reaction landscape of lactate dehydrogenase branches at multiple points creating pathways with varied reactivity. A limitation of this previous work is that the T-jump method makes only small perturbations to equilibrium and may not report conclusively on all steps in a reaction...
May 9, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28489444/noise-induced-hearing-loss-a-modern-epidemic
#13
Lema Imam, S Alam Hannan
Hearing loss is an increasingly common problem in the UK, and noise-induced hearing loss is the second most common acquired cause. There is a greater burden on the younger population, as recreational noise exposure is an important contributor. New damaging hearing behaviours have emerged including loud music exposure at concerts, nightclubs and via personal music players. The mechanism of damage is thought to involve many diverse pathways, which include oxidative damage, mechanical shearing forces and glutamate excitotoxicity...
May 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28484015/adaptation-of-cone-pigments-found-in-green-rods-for-scotopic-vision-through-a-single-amino-acid-mutation
#14
Keiichi Kojima, Yuki Matsutani, Takahiro Yamashita, Masataka Yanagawa, Yasushi Imamoto, Yumiko Yamano, Akimori Wada, Osamu Hisatomi, Kanto Nishikawa, Keisuke Sakurai, Yoshinori Shichida
Most vertebrate retinas contain a single type of rod for scotopic vision and multiple types of cones for photopic and color vision. The retinas of certain amphibian species uniquely contain two types of rods: red rods, which express rhodopsin, and green rods, which express a blue-sensitive cone pigment (M1/SWS2 group). Spontaneous activation of rhodopsin induced by thermal isomerization of the retinal chromophore has been suggested to contribute to the rod's background noise, which limits the visual threshold for scotopic vision...
May 8, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28471750/iterative-reconstruction-for-dual-energy-ct-with-an-average-image-induced-nonlocal-means-regularization
#15
Houjin Zhang, Dong Zeng, Jiahui Lin, Hao Zhang, Zhaoying Bian, Jing Huang, Yuanyuan Gao, Shanli Zhang, Hua Zhang, Qianjin Feng, Liang Zhengrong, Wufan Chen, Jianhua Ma
Reducing radiation dose in dual energy computed tomography (DECT) is highly desirable but it may lead to excessive noise in the filtered backprojection (FBP) reconstructed DECT images, which can inevitably increase the diagnostic uncertainty. To obtain clinically acceptable DECT images from low-mAs acquisitions, in this work we develop a novel scheme based on measurement of DECT data. In this scheme, inspired by the success of edge-preserving non-local means (NLM) filtering in CT imaging and the intrinsic characteristics underlying DECT images, i...
May 4, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28468354/bidirectional-fiber-ivllc-and-fiber-wireless-convergence-system-with-two-orthogonally-polarized-optical-sidebands
#16
Hai-Han Lu, Hsiao-Wen Wu, Chung-Yi Li, Chun-Ming Ho, Zih-Yi Yang, Ming-Te Cheng, Chang-Kai Lu
A bidirectional fiber-invisible laser light communication (IVLLC) and fiber-wireless convergence system with two orthogonally polarized optical sidebands for hybrid cable television (CATV)/millimeter-wave (MMW)/baseband (BB) signal transmission is proposed and experimentally demonstrated. Two optical sidebands generated by a 60-GHz MMW signal are orthogonally polarized and separated into different polarizations. These orthogonally polarized optical sidebands are delivered over a 40-km single-mode fiber (SMF) transport to effectually reduce the fiber dispersion induced by a 40-km SMF transmission and the distortion caused by the parallel polarized optical sidebands...
May 1, 2017: Optics Express
https://www.readbyqxmd.com/read/28468257/micro-doppler-ambiguity-resolution-for-wideband-terahertz-radar-using-intra-pulse-interference
#17
Qi Yang, Yuliang Qin, Bin Deng, Hongqiang Wang, Peng You
Micro-Doppler, induced by micro-motion of targets, is an important characteristic of target recognition once extracted via parameter estimation methods. However, micro-Doppler is usually too significant to result in ambiguity in the terahertz band because of its relatively high carrier frequency. Thus, a micro-Doppler ambiguity resolution method for wideband terahertz radar using intra-pulse interference is proposed in this paper. The micro-Doppler can be reduced several dozen times its true value to avoid ambiguity through intra-pulse interference processing...
April 29, 2017: Sensors
https://www.readbyqxmd.com/read/28465556/control-of-in-vivo-ictogenesis-via-endogenous-synaptic-pathways
#18
Hiram Luna-Munguia, Philip Starski, Wu Chen, Stephen Gliske, William C Stacey
The random nature of seizures poses difficult challenges for epilepsy research. There is great need for a reliable method to control the pathway to seizure onset, which would allow investigation of the mechanisms of ictogenesis and optimization of treatments. Our hypothesis is that increased random afferent synaptic activity (i.e. synaptic noise) within the epileptic focus is one endogenous method of ictogenesis. Building upon previous theoretical and in vitro work showing that synaptic noise can induce seizures, we developed a novel in vivo model of ictogenesis...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28463806/salicylate-induced-hyperacusis-in-rats-dose-and-frequency-dependent-effects
#19
Kelly Radziwon, David Holfoth, Julia Lindner, Zoe Kaier-Green, Rachael Bowler, Maxwell Urban, Richard Salvi
The use of auditory reaction time is a reliable measure of loudness perception in both animals and humans with reaction times (RT) decreasing with increasing stimulus intensity. Since abnormal loudness perception is a common feature of hyperacusis, a potentially debilitating auditory disorder in which moderate-intensity sounds are perceived as uncomfortable or painfully loud, we used RT measures to assess rats for salicylate-induced hyperacusis. A previous study using an operant conditioning RT procedure found that high-dose sodium salicylate (SS) induced hyperacusis-like behavior, i...
April 27, 2017: Hearing Research
https://www.readbyqxmd.com/read/28463247/nonscanning-moir%C3%A3-deflectometry-for-measurement-of-nonlinear-refractive-index-and-absorption-coefficient-of-liquids
#20
Shahrzad Shahrabi Farahani, Khosro Madanipour, Ata Koohian
In this work, a nonscanning measurement technique is presented for determining the nonlinear refractive index and absorption coefficient of liquid media based on Moiré deflectometry. In the proposed method two lasers are used: a low power, wide beam as probe and a high power with specific wavelength as a pump. Interaction of the pump laser beam with the nonlinear sample changes the refractive index, which leads to change in convergence/divergence of the collimated incident probe laser beam. The induced deflection is monitored by Moiré deflectometry...
May 1, 2017: Applied Optics
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