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https://www.readbyqxmd.com/read/28822748/systematical-exploration-of-transcription-factors-in-cardiomyocytes-against-hydrogen-peroxide-induced-oxidative-stress-by-danhong-injection
#1
Jingjing Zhang, Feifei Guo, Junying Wei, Minghua Xian, Shihuan Tang, Ye Zhao, Mingwei Liu, Lei Song, Ya Geng, Hongjun Yang, Chen Ding, Luqi Huang
Oxidative stress plays a vital role in many pathological processes of the cardiovascular diseases. However, the underlying mechanism remains unclear, especially on a transcription factor (TF) level. In this study, a new method, concatenated tandem array of consensus transcription factor response elements (catTFREs), and an Illumina-based RNA-seq technology were integrated and then combined with a network pharmacology strategy to systematically investigate the role of TFs in hydrogen peroxide (H2O2)-induced oxidative stress in cardiomyocytes; the damage was then rescued by Danhong injection (DHI), a Chinese standardized product approved for cardiovascular diseases treatment...
August 16, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28820976/a-hydrophobic-organelle-probe-based-on-aggregation-induced-emission-nanosuspension-preparation-and-direct-use-for-endoplasmic-reticulum-imaging-in-living-cells
#2
Sichao Zheng, Cuihong Huang, Xuyan Zhao, Yong Zhang, Shuwen Liu, Qiuhua Zhu
Organic fluorophores have a wide range of biological uses and are usually needed to be prepared as water-soluble compounds or nanoparticles for applications in aqueous biosystems owing to their hydrophobic properties, which often is a complex, time-consuming and high-cost process. Here, the nanoparticle preparation of hydrophobic fluorophores and their application in cell imaging have been investigated. It was found: a) fetal bovine serum (FBS) shows an excellent dispersion effect on hydrophobic small-molecule organic compounds; b) a hydrophobic C6-unsubstituted tetrahydropyrimidine (Me-THP-Naph) can be prepared as nanosuspensions utilizing cell culture medium with 10% FBS and directly be used as a specific real-time imaging probe for the endoplasmic reticulum (ER), a dynamic organelle playing a crucial role in many cellular processes...
August 8, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28819303/automated-segmentation-of-light-sheet-fluorescent-imaging-to-characterize-experimental-doxorubicin-induced-cardiac-injury-and-repair
#3
René R Sevag Packard, Kyung In Baek, Tyler Beebe, Nelson Jen, Yichen Ding, Feng Shi, Peng Fei, Bong Jin Kang, Po-Heng Chen, Jonathan Gau, Michael Chen, Jonathan Y Tang, Yu-Huan Shih, Yonghe Ding, Debiao Li, Xiaolei Xu, Tzung K Hsiai
This study sought to develop an automated segmentation approach based on histogram analysis of raw axial images acquired by light-sheet fluorescent imaging (LSFI) to establish rapid reconstruction of the 3-D zebrafish cardiac architecture in response to doxorubicin-induced injury and repair. Input images underwent a 4-step automated image segmentation process consisting of stationary noise removal, histogram equalization, adaptive thresholding, and image fusion followed by 3-D reconstruction. We applied this method to 3-month old zebrafish injected intraperitoneally with doxorubicin followed by LSFI at 3, 30, and 60 days post-injection...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811373/friction-law-and-hysteresis-in-granular-materials
#4
E DeGiuli, M Wyart
The macroscopic friction of particulate materials often weakens as the flow rate is increased, leading to potentially disastrous intermittent phenomena including earthquakes and landslides. We theoretically and numerically study this phenomenon in simple granular materials. We show that velocity weakening, corresponding to a nonmonotonic behavior in the friction law, [Formula: see text], is present even if the dynamic and static microscopic friction coefficients are identical, but disappears for softer particles...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28809965/hill-kinetics-as-a-noise-filter-the-role-of-transcription-factor-autoregulation-in-gene-cascades
#5
Anna Ochab-Marcinek, Jakub Jędrak, Marcin Tabaka
An intuition based on deterministic models of chemical kinetics is that population heterogeneity of transcription factor levels in cells is transmitted unchanged downstream to the target genes. We use a stochastic model of a two-gene cascade with a self-regulating upstream gene to show that, counter to the intuition, there is no simple mapping (bimodal to bimodal, unimodal to unimodal) between the shapes of the distributions of transcription factor numbers and target protein numbers in cells. Due to the presence of the two regulations, the system contains two nonlinear transfer functions, defined by the Hill kinetics of transcription factor binding...
August 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28808196/antioxidant-mediated-response-of-scoparia-dulcis-in-noise-induced-redox-imbalance-and-immunohistochemical-changes-in-rat-brain
#6
Wankupar Wankhar, Sakthivel Srinivasan, Ravindran Rajan, Rathinasamy Sheeladevi
Noise has been regarded as an environmental/occupational stressor that causes damages to both auditory and non-auditory organs. Prolonged exposure to these mediators of stress has often resulted in detrimental effect, where oxidative/nitrosative stress plays a major role. Hence, it would be appropriate to examine the possible role of free radicals in brain discrete regions and the "antioxidants" mediated response of S. dulcis. Animals were subjected to noise stress for 15 days (100 dB/4 hours/day) and estimation of endogenous free radical and antioxidant activity were carried out on brain discrete regions (the cerebral cortex, cerebellum, brainstem, striatum, hippocampus and hypothalamus)...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28806500/doxepin-mitigates-noise-induced-neuronal-damage-in-primary-auditory-cortex-of-mice-via-suppression-of-acid-sphingomyelinase-ceramide-pathway
#7
Yu-Ting Su, Xing-Xing Meng, Xi Zhang, Yi-Bin Guo, Hai-Jun Zhang, Yao-Ping Cheng, Xiao-Ping Xie, Yao-Ming Chang, Jun-Xiang Bao
Neuronal damage in primary auditory cortex (A1) underlies complex manifestations of noise exposure, prevention of which is critical for health maintenance. Acid sphingomyelinase (ASM) catalyzes generation of ceramide (Cer) which if over-activated mediates neuronal disorders in various diseases. Tricyclic antidepressants (TCAs), by restraining ASM/Cer, benefits multiple neuronal anomalies, so we aimed to elucidate the effect of TCA on noise induced hearing loss and auditory cortex derangement, unraveling mechanism involved...
August 14, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28805692/real-time-rain-rate-evaluation-via-satellite-downlink-signal-attenuation-measurement
#8
Filippo Giannetti, Ruggero Reggiannini, Marco Moretti, Elisa Adirosi, Luca Baldini, Luca Facheris, Andrea Antonini, Samantha Melani, Giacomo Bacci, Antonio Petrolino, Attilio Vaccaro
We present the NEFOCAST project (named by the contraction of "Nefele", which is the Italian spelling for the mythological cloud nymph Nephele, and "forecast"), funded by the Tuscany Region, about the feasibility of a system for the detection and monitoring of precipitation fields over the regional territory based on the use of a widespread network of new-generation Eutelsat "SmartLNB" (smart low-noise block converter) domestic terminals. Though primarily intended for interactive satellite services, these devices can also be used as weather sensors, as they have the capability of measuring the rain-induced attenuation incurred by the downlink signal and relaying it on an auxiliary return channel...
August 12, 2017: Sensors
https://www.readbyqxmd.com/read/28796850/the-economic-impact-of-adult-hearing-loss-a-systematic-review
#9
Matthew G Huddle, Adele M Goman, Faradia C Kernizan, Danielle M Foley, Carrie Price, Kevin D Frick, Frank R Lin
Importance: Hearing impairment (HI) is highly prevalent in older adults and has been associated with adverse health outcomes. However, the overall economic impact of HI is not well described. Objective: The goal of this review was to summarize available data on all relevant costs associated with HI among adults. Evidence Review: A literature search of PubMed, Embase, the Cochrane Library, CINAHL, and Scopus was conducted in August 2015. For this systematic review, data extraction and quality assessment were performed by 2 independent reviewers...
August 10, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28794216/higher-songs-of-city-birds-may-not-be-an-individual-response-to-noise
#10
Sue Anne Zollinger, Peter J B Slater, Erwin Nemeth, Henrik Brumm
It has been observed in many songbird species that populations in noisy urban areas sing with a higher minimum frequency than do matched populations in quieter, less developed areas. However, why and how this divergence occurs is not yet understood. We experimentally tested whether chronic noise exposure during vocal learning results in songs with higher minimum frequencies in great tits (Parus major), the first species for which a correlation between anthropogenic noise and song frequency was observed. We also tested vocal plasticity of adult great tits in response to changing background noise levels by measuring song frequency and amplitude as we changed noise conditions...
August 16, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28791082/protective-effect-of-nigella-sativa-oil-on-acoustic-trauma-induced-hearing-loss-in-rats
#11
Belde Culhaoglu, Selim S Erbek, Seyra Erbek, Evren Hizal
Acoustic trauma is a common reason for hearing loss. Different agents are used to prevent the harmful effect of acoustic trauma on hearing. The aim of this study was to evaluate the potential preventive effect of Nigella sativa (black cumin) oil in acoustic trauma. Our experimental study was conducted with 20 Sprague Downey female rats (mean age, 12 months; mean weight 250 g). All of the procedures were held under general anesthesia. Following otoscopic examinations, baseline-hearing thresholds were obtained using auditory brainstem responses (ABR)...
July 18, 2017: Audiology Research
https://www.readbyqxmd.com/read/28790302/formation-and-suppression-of-acoustic-memories-during-human-sleep
#12
Thomas Andrillon, Daniel Pressnitzer, Damien Léger, Sid Kouider
Sleep and memory are deeply related, but the nature of the neuroplastic processes induced by sleep remains unclear. Here, we report that memory traces can be both formed or suppressed during sleep, depending on sleep phase. We played samples of acoustic noise to sleeping human listeners. Repeated exposure to a novel noise during Rapid Eye Movements (REM) or light non-REM (NREM) sleep leads to improvements in behavioral performance upon awakening. Strikingly, the same exposure during deep NREM sleep leads to impaired performance upon awakening...
August 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28781154/oral-administration-of-geranylgeranylacetone-to-protect-vestibular-hair-cells
#13
Shinpei Nagato, Kazuma Sugahara, Yoshinobu Hirose, Yousuke Takemoto, Makoto Hashimoto, Hironori Fujii, Hiroshi Yamashita
OBJECTIVE: We recently reported that the heat shock response played a major role in the protection of hair cells against stress. Oral administration of the heat shock inducer, geranylgeranylacetone (GGA) protected hair cells against intense noise. In our present study, we investigated the effect of GGA on vestibular hair cell death induced by an aminoglycoside. METHODS: We used CBA/N mice aged 4-6 weeks. The mice were divided into two groups, GGA and control. Mice in the GGA group were fed a diet containing GGA (0...
August 3, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28777830/multivariate-bayesian-decoding-of-single-trial-event-related-fmri-responses-for-memory-retrieval-of-voluntary-actions
#14
Dongha Lee, Sungjae Yun, Changwon Jang, Hae-Jeong Park
This study proposes a method for classifying event-related fMRI responses in a specialized setting of many known but few unknown stimuli presented in a rapid event-related design. Compared to block design fMRI signals, classification of the response to a single or a few stimulus trial(s) is not a trivial problem due to contamination by preceding events as well as the low signal-to-noise ratio. To overcome such problems, we proposed a single trial-based classification method of rapid event-related fMRI signals utilizing sparse multivariate Bayesian decoding of spatio-temporal fMRI responses...
2017: PloS One
https://www.readbyqxmd.com/read/28777617/evolution-free-hamiltonian-parameter-estimation-through-zeeman-markers
#15
Daniel Burgarth, Ashok Ajoy
We provide a protocol for Hamiltonian parameter estimation which relies only on the Zeeman effect. No time-dependent quantities need to be measured; it fully suffices to observe spectral shifts induced by fields applied to local "markers." We demonstrate the idea with a simple tight-binding Hamiltonian and numerically show stability with respect to Gaussian noise on the spectral measurements. Then we generalize the result to show applicability to a wide range of systems, including quantum spin chains, networks of qubits, and coupled harmonic oscillators, and suggest potential experimental implementations...
July 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28775262/single-shot-monitoring-of-ultrafast-processes-via-x-ray-streaking-at-a-free-electron-laser
#16
Michele Buzzi, Mikako Makita, Ludovic Howald, Armin Kleibert, Boris Vodungbo, Pablo Maldonado, Jörg Raabe, Nicolas Jaouen, Harald Redlin, Kai Tiedtke, Peter M Oppeneer, Christian David, Frithjof Nolting, Jan Lüning
The advent of x-ray free electron lasers has extended the unique capabilities of resonant x-ray spectroscopy techniques to ultrafast time scales. Here, we report on a novel experimental method that allows retrieving with a single x-ray pulse the time evolution of an ultrafast process, not only at a few discrete time delays, but continuously over an extended time window. We used a single x-ray pulse to resolve the laser-induced ultrafast demagnetisation dynamics in a thin cobalt film over a time window of about 1...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28774831/acoustic-stress-induces-long-term-severe-intestinal-inflammation-in-the-mouse
#17
Silvia Miranda, María Estela Roux
The influence of noise on the presentation and progression of inflammatory bowel diseases has been poorly analyzed. We designed this study to investigate immediate and late effects of acoustic stress (AS) on small intestine. To this aim, CBA/J, BALB/c and DBA/2 mice were divided into AS and control groups. AS mice were exposed to noise (300Hz-70dB) during 24hs and randomized into: A) Acute effects group: mice were killed after AS; L) Late effects group: mice were killed 3 weeks after AS and O) Over-exposed effects group: mice were submitted to AS once a week during a month and killed...
July 31, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28774063/experimental-and-theoretical-analysis-of-sound-absorption-properties-of-finely-perforated-wooden-panels
#18
Boqi Song, Limin Peng, Feng Fu, Meihong Liu, Houjiang Zhang
Perforated wooden panels are typically utilized as a resonant sound absorbing material in indoor noise control. In this paper, the absorption properties of wooden panels perforated with tiny holes of 1-3 mm diameter were studied both experimentally and theoretically. The Maa-MPP (micro perforated panels) model and the Maa-Flex model were applied to predict the absorption regularities of finely perforated wooden panels. A relative impedance comparison and full-factorial experiments were carried out to verify the feasibility of the theoretical models...
November 22, 2016: Materials
https://www.readbyqxmd.com/read/28772884/enhanced-thermo-optical-switching-of-paraffin-wax-composite-spots-under-laser-heating
#19
Asmaa Said, Abeer Salah, Gamal Abdel Fattah
Thermo-optical switches are of particular significance in communications networks where increasingly high switching speeds are required. Phase change materials (PCMs), in particular those based on paraffin wax, provide wealth of exciting applications with unusual thermally-induced switching properties, only limited by paraffin's rather low thermal conductivity. In this paper, the use of different carbon fillers as thermal conductivity enhancers for paraffin has been investigated, and a novel structure based on spot of paraffin wax as a thermo-optic switch is presented...
May 12, 2017: Materials
https://www.readbyqxmd.com/read/28764481/numerical-investigation-of-cavity-self-oscillation-and-noise-radiation-induced-by-turbulent-flow-at-non-zero-inclination-angle
#20
Yiping Wang, Chengqi Guo, Chengjian Peng, Chenguang Yu
A hybrid numerical approach was used on a three-dimensional cavity at a non-zero inclination angle of the upstream section to reveal the mechanism of self-oscillation and the characteristics of far-field sound field. In this hybrid approach, the unsteady flow physics was captured by a compressible large eddy simulation, and the far-field sound field was calculated by the FW-H integral equation, with the noise source provided by near-field calculation. The mechanism of self-oscillation was revealed based on the instantaneous flow field structure and the pressure inside the cavity...
July 2017: Journal of the Acoustical Society of America
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