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https://www.readbyqxmd.com/read/28230966/increasing-peak-capacity-in-non-targeted-omics-applications-by-combining-full-scan-field-asymmetric-waveform-ion-mobility-spectrometry-with-liquid-chromatography-mass-spectrometry
#1
Kayleigh L Arthur, Matthew A Turner, James C Reynolds, Colin S Creaser
Full scan field asymmetric waveform ion mobility spectrometry (FAIMS) combined with liquid chromatography and mass spectrometry (LC-FAIMS-MS) is shown to enhance peak capacity for omics applications. A miniaturized FAIMS device capable of rapid compensation field scanning has been incorporated into an ultra-high performance liquid chromatography (UHPLC) and time-of-flight (TOF) mass spectrometry analysis, allowing the acquisition of full scan FAIMS and MS nested data sets within the timescale of a UHPLC peak...
February 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28227611/a-study-of-the-effect-of-subject-motion-to-pulse-rate-estimation
#2
Beilei Xu, Himanshu Madhu, Lalit K Mestha, Beilei Xu, Himanshu Madhu, Lalit K Mestha, Lalit K Mestha, Beilei Xu, Himanshu Madhu
We presented a systematic study of how subject head motion affects pulse rate estimation using photoplethysmography from the subject's face. We evaluated the performance at various steps in the process, including object tracking, skin blob detection, pulse signal extraction and pulse rate estimation. We demonstrated that the signal-to-noise ratio of the power spectrum is a good indicator of signal artifacts induced by subject motion, thus can be used as a quantitative metric in continuous pulse rate monitoring to reduce estimation errors...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227507/efficient-assembly-of-multi-color-fiberless-optoelectrodes-with-on-board-light-sources-for-neural-stimulation-and-recording
#3
K Kampasi, J Seymour, E Stark, G Buzsaki, K D Wise, E Yoon, K Kampasi, J Seymour, E Stark, G Buzsaki, K D Wise, E Yoon, E Yoon, K Kampasi, J Seymour, G Buzsaki, E Stark, K D Wise
Fiberless optoelectrodes are an emerging tool to enable brain circuit mapping by providing precise optical modulation and electrical monitoring of many neurons. While optoelectrodes having an on-board light source offer compact and optically efficient device solutions, many of them fail to provide robust thermal and electrical design to fully exploit the recording capabilities of the device. In this work, we present a novel fiberless multicolor optoelectrode solution, which meets the optical and thermal design requirements of an in vivo neural optoelectrode and offers potential for low-noise neural recording...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227311/two-microphones-spectral-coherence-based-speech-enhancement-for-hearing-aids-using-smartphone-as-an-assistive-device
#4
Chandan K A Reddy, Yiya Hao, Issa Panahi, Chandan K A Reddy, Yiya Hao, Issa Panahi, Issa Panahi, Chandan K A Reddy, Yiya Hao
In this paper, we present a new Speech Enhancement (SE) technique capable of running on a smartphone, as an assistive device for hearing aids (HAs). The developed method incorporates the coherence between the speech and noise signals to obtain a SE gain function which is used in conjunction with the gain function obtained by Spectral Subtraction using adaptive gain averaging. SE using coherence based gain function is found to suppress the background noise well, while inducing speech distortion. On the other hand, SE using Spectral Subtraction improves speech quality with tolerable speech distortion, but introduces background musical noise for certain noise types...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226994/high-dielectric-material-in-mri-numerical-assessment-of-the-reduction-of-the-induced-local-power-on-implanted-cardiac-leads
#5
Eugenio Mattei, Elena Lucano, Federica Censi, Leonardo M Angelone, Giovanni Calcagnini, Eugenio Mattei, Elena Lucano, Federica Censi, Leonardo M Angelone, Giovanni Calcagnini, Eugenio Mattei, Giovanni Calcagnini, Elena Lucano, Leonardo M Angelone, Federica Censi
High dielectric materials (HDM) have been proposed in magnetic resonance imaging (MRI) to increase the signal-to-noise ratio (SNR) of the images acquired while reducing the radiofrequency (RF) absorption in tissue. The aim of this study is to assess the potential merit of using HDM to reduce power induced at the tip of an endocardial lead in patients undergoing MRI. Numerical simulations were performed using a commercial finite-differences time-domain (FDTD) software to model the RF field generated by a birdcage body coil at 64 MHz on a human body model...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226845/validation-of-empirical-mode-decomposition-combined-with-notch-filtering-to-extract-electrical-stimulation-artifact-from-surface-electromyograms-during-functional-electrical-stimulation
#6
Rakesh Pilkar, Arvind Ramanujam, Erica Garbarini, Gail Forrest, Rakesh Pilkar, Arvind Ramanujam, Erica Garbarini, Gail Forrest, Rakesh Pilkar, Erica Garbarini, Arvind Ramanujam, Gail Forrest
This paper presents the validity of Empirical Mode Decomposition (EMD) combined with Notch filtering to remove the electrical stimulation (ES) artifact from surface electromyogram (EMG) data for interpretation of muscle responses during Functional Electrical Stimulation (FES) experiments. We hypothesized that the EMD algorithm provides a suitable platform for decomposing the EMG signal into physically meaningful intrinsic mode functions (IMFs) which can be further used to isolate electrical stimulation (ES) artifact...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226721/overcoming-spatio-temporal-limitations-using-dynamically-scaled-in-vitro-pc-mri-a-flow-field-comparison-to-true-scale-computer-simulations-of-idealized-stented-and-patient-specific-left-main-bifurcations
#7
Susann Beier, John Ormiston, Mark Webster, John Cater, Stuart Norris, Pau Medrano-Gracia, Alistair Young, Kathleen Gilbert, Brett Cowan, Susann Beier, John Ormiston, Mark Webster, John Cater, Stuart Norris, Pau Medrano-Gracia, Alistair Young, Kathleen Gilbert, Brett Cowan, Stuart Norris, Brett Cowan, Pau Medrano-Gracia, Kathleen Gilbert, Mark Webster, Alistair Young, Susann Beier, John Cater, John Ormiston
The majority of patients with angina or heart failure have coronary artery disease. Left main bifurcations are particularly susceptible to pathological narrowing. Flow is a major factor of atheroma development, but limitations in imaging technology such as spatio-temporal resolution, signal-to-noise ratio (SNRv), and imaging artefacts prevent in vivo investigations. Computational fluid dynamics (CFD) modelling is a common numerical approach to study flow, but it requires a cautious and rigorous application for meaningful results...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225587/compms2miner-an-automatable-metabolite-identification-visualization-and-data-sharing-r-package-for-high-resolution-lc-ms-datasets
#8
William Matthew Bell Edmands, Lauren M Petrick, Dinesh Kumar Barupal, Augustin Scalbert, Mark Wilson, Jeffrey Wickliffe, Stephen M Rappaport
A long-standing challenge of untargeted metabolomic profiling by ultrahigh performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) is efficient transition from unknown mass spectral features to confident metabolite annotations. The compMS2Miner (Comprehensive MS2 Miner) package was developed in the R language to facilitate rapid, comprehensive feature annotation using a peak-picker-output and MS2 data files as inputs. The number of MS2 spectra that can be collected during a metabolomic profiling experiment far outweigh the amount of time required for pain-staking manual interpretation, therefore a degree of software workflow autonomy is required for broad-scale metabolite annotation...
February 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28225002/topologically-protected-localised-states-in-spin-chains
#9
Marta P Estarellas, Irene D'Amico, Timothy P Spiller
We consider spin chain families inspired by the Su, Schrieffer and Hegger (SSH) model. We demonstrate explicitly the topologically induced spatial localisation of quantum states in our systems. We present detailed investigations of the effects of random noise, showing that these topologically protected states are very robust against this type of perturbation. Systems with such topological robustness are clearly good candidates for quantum information tasks and we discuss some potential applications. Thus, we present interesting spin chain models which show promising applications for quantum devices...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224282/micrornas-effective-elements-in-ear-related-diseases-and-hearing-loss
#10
REVIEW
Mohammad-Reza Mahmoudian-Sani, Ameneh Mehri-Ghahfarrokhi, Fereshteh Ahmadinejad, Morteza Hashemzadeh-Chaleshtori, Massoud Saidijam, Mohammad-Saeid Jami
miRNAs are important factors for post-transcriptional process that controls gene expression at mRNA level. Various biological processes, including growth and differentiation, are regulated by miRNAs. miRNAs have been demonstrated to play an essential role in development and progression of hearing loss. Nowadays, miRNAs are known as critical factors involved in different physiological, biological, and pathological processes, such as gene expression, progressive sensorineural hearing loss, age-related hearing loss, noise-induced hearing loss, cholesteatoma, schwannomas, and inner ear inflammation...
February 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28223190/association-of-tagsnp-in-lncrna-hotair-with-susceptibility-to-noise-induced-hearing-loss-in-a-chinese-population
#11
Boshen Wang, Enmin Ding, Huanxi Shen, Jianfeng Wang, Kai Sun, Shi Chen, Lei Han, Hengdong Zhang, Baoli Zhu, Ming Xu
BACKGROUND: Noise-induced hearing loss (NIHL) is a multifactorial disease, and dysregulation of oxidative stress is universally acknowledged as one crucial pathogenic factor for this disease. Recently studies have found the LncRNA HOTAIR is involved in the alteration of oxidative stress level, cell proliferation, cell cycle progression, and apoptosis. Considering the effects of lncRNA HOTAIR in cellular oxidative stress, we sought to investigate the influence of lncRNA HOTAIR variants on the risk of NIHL...
February 18, 2017: Hearing Research
https://www.readbyqxmd.com/read/28220907/exposure-to-excessive-sounds-and-hearing-status-in-academic-classical-music-students
#12
Małgorzata Pawlaczyk-Łuszczyńska, Małgorzata Zamojska-Daniszewska, Adam Dudarewicz, Kamil Zaborowski
OBJECTIVES: The aim of this study was to assess hearing of music students in relation to their exposure to excessive sounds. MATERIAL AND METHODS: Standard pure-tone audiometry (PTA) was performed in 168 music students, aged 22.5±2.5 years. The control group included 67 subjects, non-music students and non-musicians, aged 22.8±3.3 years. Data on the study subjects' musical experience, instruments in use, time of weekly practice and additional risk factors for noise-induced hearing loss (NIHL) were identified by means of a questionnaire survey...
February 21, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28220877/impact-of-bounded-noise-on-the-formation-and-instability-of-spiral-wave-in-a-2d-lattice-of-neurons
#13
Yuangen Yao, Haiyou Deng, Ming Yi, Jun Ma
Spiral waves in the neocortex may provide a spatial framework to organize cortical oscillations, thus help signal communication. However, noise influences spiral wave. Many previous theoretical studies about noise mainly focus on unbounded Gaussian noise, which contradicts that a real physical quantity is always bounded. Furthermore, non-Gaussian noise is also important for dynamical behaviors of excitable media. Nevertheless, there are no results concerning the effect of bounded noise on spiral wave till now...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28215378/program-sustainability-hearing-loss-and-tinnitus-prevention-in-american-indian-communities
#14
William Hal Martin, Judith L Sobel, Susan E Griest, Linda C Howarth, Thomas M Becker
INTRODUCTION: An important goal of any health promotion effort is to have it maintained in delivery and effectiveness over time. The purpose of this study was to establish a community-based noise-induced hearing loss and tinnitus prevention program in three different types of American Indian communities and evaluate them for evidence of long-term sustainability. METHODS: The target population was fourth- and fifth-grade students from three different models of American Indian communities...
March 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28215085/peptide-functionalized-gold-nanoparticles-as-a-stimuli-responsive-contrast-medium-in-multi-photon-microscopy
#15
Johan Borglin, Robert Selegård, Daniel Aili, Marica B Ericson
There is a need for biochemical contrast mediators with high signal to noise ratios enabling non-invasive biomedical sensing, e.g., for neural sensing, protein-protein interactions, in addition to cancer diagnostics. The translational challenge is to develop a biocompatible approach ensuring high biochemical contrast while avoiding a raise of the background signal. We here present a concept where gold nanoparticles (AuNPs) can be utilized as a stimuli responsive contrast medium by chemically triggering their ability to exhibit multiphoton induced luminescence (MIL) when performing multi-photon laser scanning microscopy (MPM)...
February 20, 2017: Nano Letters
https://www.readbyqxmd.com/read/28214516/saturation-of-long-term-potentiation-in-the-dorsal-cochlear-nucleus-and-its-pharmacological-reversal-in-an-experimental-model-of-tinnitus
#16
Thomas Tagoe, Daniel Deeping, Martine Hamann
Animal models have demonstrated that tinnitus is a pathology of dysfunctional excitability in the central auditory system, in particular in the dorsal cochlear nucleus (DCN) of the brainstem. We used a murine model and studied whether acoustic over-exposure leading to hearing loss and tinnitus, affects long-term potentiation (LTP) at DCN multisensory synapses. Whole cell and field potential recordings were used to study the effects on release probability and synaptic plasticity, respectively in brainstem slices...
February 16, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28212114/discriminative-feature-representation-an-effective-postprocessing-solution-to-low-dose-ct-imaging
#17
Yang Chen, Jin Liu, Yining Hu, Jian Yang, Luyao Shi, Huazhong Shu, Zhiguo Gui, Gouenou Coatrieux, Limin Luo
This paper proposes a concise and effective approach termed discriminative feature representation (DFR) for low dose computerized tomography (LDCT) image processing, which is currently a challenging problem in medical imaging field. This DFR method assumes LDCT images as the superposition of desirable high dose CT (HDCT) 3D features and undesirable noise-artifact 3D features (the combined term of noise and artifact features induced by low dose scan protocols), and the decomposed HDCT features are used to provide the processed LDCT images with higher quality...
February 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28210188/non-contact-photoacoustic-imaging-using-a-commercial-heterodyne-interferometer
#18
Chao Tian, Ting Feng, Cheng Wang, Shengchun Liu, Qian Cheng, David E Oliver, Xueding Wang, Guan Xu
Most current photoacoustic imaging (PAI) systems employ piezoelectric transducers to receive photoacoustic signals, which requires coupling medium to facilitate photoacoustic wave propagation and are not favored in many applications. Here, we report an all-optical non-contact PAI system based on a commercial heterodyne interferometer working at 1550 nm. The interferometer remotely detects ultrasound-induced surface vibration and does not involve any physical contact with the sample. The theoretically predicated and experimentally measured noise equivalent detection limits of the optical sensor are about 4...
December 1, 2016: IEEE Sensors Journal
https://www.readbyqxmd.com/read/28209736/pejvakin-a-candidate-stereociliary-rootlet-protein-regulates-hair-cell-function-in-a-cell-autonomous-manner
#19
Marcin Kazmierczak, Piotr Kazmierczak, Anthony W Peng, Suzan L Harris, Prahar Shah, Jean-Luc Puel, Marc Lenoir, Santos J Franco, Martin Schwander
Mutations in the Pejvakin (PJVK) gene are thought to cause auditory neuropathy and hearing loss of cochlear origin by affecting noise-induced peroxisome proliferation in auditory hair cells and neurons. Here we demonstrate that loss of pejvakin in hair cells, but not in neurons, causes profound hearing loss and outer hair cell degeneration in mice. Pejvakin binds to and co-localizes with the rootlet component TRIOBP at the base of stereocilia in injectoporated hair cells, a pattern that is disrupted by deafness-associated PJVK mutations...
February 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28208484/subtle-escaping-modes-and-subset-of-patterns-from-a-nonhyperbolic-chaotic-attractor
#20
Zhen Chen, Xianbin Liu
Noise-induced escape from the domain of attraction of a nonhyperbolic chaotic attractor in a periodically excited nonlinear oscillator is further investigated. Deviations are found to be amplified at the primary homoclinic tangency from which the optimal force begins to fluctuate dramatically. Escaping trajectories turn out to possess several modes to pass through the saddle cycle on the basin boundary, and each mode corresponds to a certain type of value of the action plot, respectively. A subset of the pattern of fluctuational paths from the chaotic attractor is obtained, showing the existence of complicated singularities...
January 2017: Physical Review. E
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