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Qiuhong Xue, Caihong Li, Jia Chen, Hongmei Guo, Dongqing Li, Xianglei Wu
CONTEXT: The audiological features and cochlear morphology of individuals with noise-induced hearing loss (NIHL) are well characterized. However, the molecular processes in the cochlea are not well understood. AIMS: To explore the role of the endoplasmic reticulum stress (ERS) response in the guinea pig model of cochlear damage induced by exposure to intense noise. SETTINGS AND DESIGN: A pilot case-control study. SUBJECTS AND METHODS: Forty-eight guinea pigs were divided into four equal groups...
September 2016: Noise & Health
Tengku Siti Hajar Haryuna, Wibi Riawan, Ardyansyah Nasution, Suprapto Ma'at, Juliandi Harahap, Indri Adriztina
Introduction The structural changes underlying permanent noise-induced hearing loss (NIHL) include loss of the sensory hair cells, damage to their stereocilia, and supporting tissues within the cochlear lateral wall. Objective The objective of this study is to demonstrate curcumin as a safe and effective therapeutic agent in the prevention and treatment for fibroblasts damage within the cochlear supporting tissues and lateral wall through cell death pathway. Methods We divided 24 Rattus norvegicus into 4 groups, Group 1: control; Group 2: noise (+); Group 3: noise (+), 50 mg/day curcumin (+); Group 4: noise (+), 100 mg/day curcumin (+)...
October 2016: International Archives of Otorhinolaryngology
Arve Lie, Bo Engdahl, Howard J Hoffman, Chuan-Ming Li, Kristian Tambs
OBJECTIVES/HYPOTHESIS: To study the prevalence and usefulness of audiometric notches in the diagnosis of noise-induced hearing loss (NIHL). STUDY DESIGN: Audiograms and data on noise exposure from 23,297 men and 26,477 women, aged 20 to 101 years, from the Nord-Trøndelag Hearing Loss Study, 1996-1998. METHODS: The prevalence of four types of audiometric notches (Coles, Hoffman, Wilson) and 4 kHz notch were computed in relation to occupational noise exposure, age, sex, and report of recurrent ear infections...
October 3, 2016: Laryngoscope
Hugo Carlos Pedroso, Cláudia Giglio de Oliveira Gonçalves
Objective: The article aims to analyze the perception and knowledge of health professionals working in primary health care networks in the Municipality of Curitiba - Paraná, regarding the compulsory notification of Induced Hearing Loss Noise (NIHL) in the National Notifiable Diseases Information System (SINAN). Methods: We performed a transversal cohort study in Curitiba, analyzing perception and knowledge of health professionals working in the primary health care networks in the Municipality of Curitiba, regarding the compulsory notification of NIHL in SINAN, from 2007 to 2014, featuring the reported cases and exploring the situational analysis of the NIHL notification, through a questionnaire and a structured news conference...
September 26, 2016: CoDAS
Arve Lie, Marit Skogstad, Torstein Seip Johnsen, Bo Engdahl, Kristian Tambs
OBJECTIVE: The aim of this study was to analyse longitudinal data to assess the risk of noise-induced hearing loss (NIHL) in Norwegian railway workers. DESIGN: Longitudinal. SETTING: A major Norwegian railway company. METHODS: We examined data from the first and last audiograms for the period 1991-2014, from 9640 railway workers with varying occupational noise exposure and with an average observation period of 10 years...
2016: BMJ Open
Joel Lavinsky, Marshall Ge, Amanda L Crow, Calvin Pan, Juemei Wang, Pezhman Salehi, Anthony Myint, Eleazar Eskin, Hooman Allayee, Aldons J Lusis, Rick A Friedman
The discovery of environmentally specific genetic effects is crucial to the understanding of complex traits, such as susceptibility to noise-induced hearing loss (NIHL). We describe the first genome-wide association study (GWAS) for NIHL in a large and well-characterized population of inbred mouse strains, known as the Hybrid Mouse Diversity Panel (HMDP). We recorded auditory brainstem response (ABR) thresholds both pre and post 2-hr exposure to 10-kHz octave band noise at 108 dB sound pressure level in 5-6-wk-old female mice from the HMDP (4-5 mice/strain)...
October 13, 2016: G3: Genes—Genomes—Genetics
Kayla Hill, Hu Yuan, Xianren Wang, Su-Hua Sha
UNLABELLED: Noise-induced hearing loss (NIHL) is a major unresolved public health problem. Here, we investigate pathomechanisms of sensory hair cell death and suggest a novel target for protective intervention. Cellular survival depends upon maintenance of energy homeostasis, largely by AMP-activated protein kinase (AMPK). In response to a noise exposure in CBA/J mice, the levels of phosphorylated AMPKα increased in hair cells in a noise intensity-dependent manner. Inhibition of AMPK via siRNA or the pharmacological inhibitor compound C attenuated noise-induced loss of outer hair cells (OHCs) and synaptic ribbons, and preserved auditory function...
July 13, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Ishan Bhatt, Susan Phillips, Scott Richter, Denise Tucker, Kristine Lundgren, Robin Morehouse, Vincent Henrich
OBJECTIVE: A non-synonymous single nucleotide polymorphism (rs61742642; C to T, P386S) in the ligand-binding domain of human estrogen-related receptor beta (ESRRβ) showed possible association to noise-induced hearing loss (NIHL) in our previous study. DESIGN: This study was conducted to examine the effect of the ESRRβ rs61742642 T variant on temporary threshold shift (TTS). TTS was induced by 10 minutes of exposure to audiometric narrow-band noise centered at 2000 Hz...
October 2016: International Journal of Audiology
Michiel P Peters, Peter Z Feczko, Karel Tsang, Bert van Rietbergen, Chris J Arts, Peter J Emans
BACKGROUND: Historically it has been suggested that noise-induced hearing loss (NIHL) affects approximately 50% of the orthopedic surgery personnel. This noise may be partially caused by the use of powered saw systems that are used to make the bone cuts. The first goal was to quantify and compare the noise emission of these different saw systems during total knee arthroplasty (TKA) surgery. A second goal was to estimate the occupational NIHL risk for the orthopedic surgery personnel in TKA surgery by quantifying the total daily noise emission spectrum during TKA surgery and to compare this to the Dutch Occupational Health Organization guidelines...
May 27, 2016: Journal of Arthroplasty
Barak Gordon, Zohar Joachims, Hila Bar Cohen, Alon Grossman, Estela Derazne, Erez Carmon, Michal Zilberberg, Yuval Levy
OBJECTIVE: To investigate the natural history of hearing loss (HL) in Israeli military aviators and its risk factors. METHODS: Audiometric results of aviators with available audiometry at ages 30 and 40 years, and up to their last available audiometry were retrieved. HL DEFINITION: pure-tone threshold (PTT) of 30 dB or higher in at least one frequency in at least one ear, moderate-to-severe (M-S) HL as PTT of 45 dB or higher, and suspected noise-induced HL (NIHL) as HL at 3 to 6 kHz...
July 2016: Military Medicine
Mun Young Chang, Song Yee Han, Hyeon-Cheol Shin, Jang Yul Byun, Yoon Chan Rah, Moo Kyun Park
OBJECTIVE: Noise is one of the most common causes of hearing loss. Approximately 16% of American teenagers (12-19 years) have hearing loss caused by loud noise. The implication of noise-induced hearing loss (NIHL) in teenagers has received increasing attention. Although temporary threshold shift (TTS), a type of NIHL, is a transient hearing loss, it can accelerate age-related hearing loss. Reactive oxygen species are a primary cause of TTS. As the polyphenols from Ecklonia cava are known to have potent antioxidant effects, we investigated the protective effects of a purified polyphenolic extract of Ecklonia cava (PPEE) against TTS in mice...
August 2016: International Journal of Pediatric Otorhinolaryngology
Małgorzata Pawlaczyk-Łuszczyńska, Adam Dudarewicz, Norman Czaja, Alicja Bortkiewicz
BACKGROUND: The aim of the study was to analyze the hearing status of employees of a furniture factory with respect to their exposure to noise and the presence of additional risk factors of noise-induced hearing loss (NIHL). MATERIAL AND METHODS: Noise measurements, questionnaire survey and assessment of hearing, using pure tone audiometry, were carried out in 50 male workers, aged 20-57 years, directly employed in the manufacture of furniture. The actual workers' hearing threshold levels (HTLs) were compared with the predictions calculated according to PN-ISO 1999:2000 based on age, gender and noise exposure...
2016: Medycyna Pracy
Afsaneh Doosti, Yones Lotfi, Enayatollah Bakhshi
Likelihood of developing noise induced hearing loss (NIHL) is affected by some factors such as genes, nutrition and healthy hearing habits. We investigated this study to determine the effect of hyperlipidemia on NIHL. In a case-control study, 144 workers who exposed to continuous noise more than 85 dBA (88-89 dBA) from a textile factory in Tehran were examined. Serum Blood test results as index for dyslipidemi, were collected and audiometry tests were carried out to analyze the association of hyperlipidemian and NIHL...
June 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
Q Y Yang, X R Xu, J Jiao, L H He, S F Yu, G Z Gu, G S Chen, W H Zhou, H Wu, Y H Li
OBJECTIVE: To investigate association between genetic polymorphism in the grainyhead-like 2 gene (GRHL2) and noise-induced hearing loss (NIHL) in the Chinese population. METHODS: A matched case-control association study was employed, In which, 3 790 workers exposed to continuous and steady-state occupational noise in a steel factory participated. The questionnaires were adopted to collect individual features and audiometry tests performed. In the sstudy, 286 subjects were diagnosed as cases, Which were each designated on the basis of the matched criterion, and 286 paired samples were selected finally...
June 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Patrick Krauss, Konstantin Tziridis, Stefanie Buerbank, Achim Schilling, Holger Schulze
Noise induced hearing loss (NIHL) is a common disease in modern societies and may lead to maladaptations within the auditory system that finally result in subjective tinnitus. Available therapies may only alleviate the symptoms rather than restore normal hearing. In a previous study we demonstrated that the prophylactic application of Ginkgo biloba extract EGb 761® significantly reduces NIHL and tinnitus development in our Mongolian gerbil (Meriones unguiculatus) animal model. Here, we tested whether the application of EGb 761® has beneficial effects after the formation of permanent NIHL and tinnitus...
2016: PloS One
Rui Ye, Jun Liu, Zhiying Jia, Hongyang Wang, YongAn Wang, Wei Sun, Xuan Wu, Zhifei Zhao, Baolong Niu, Xingqi Li, Guanghai Dai, Jianxiong Li
BACKGROUND There is increasing evidence that adenosine triphosphate (ATP), a well-known neurotransmitter and neuromodulator in the central nervous system, plays an important role as an extracellular chemical messenger in the cochlea. MATERIAL AND METHODS Using a whole-cell recording technique, we studied the effects of ATP on isolated Hensen's cells, which are supporting cells in the cochlea, to determine if they are involved in the transduction of ions with hair cells. RESULTS ATP (0.1-10 µM) reduced the potassium current (IK+) in the majority of the recorded Hensen's cells (21 out of 25 cells)...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Liam Masterson, James Howard, Zi Wei Liu, John Phillips
OBJECTIVE: Asymmetrical hearing thresholds are common in people claiming compensation for noise-induced hearing loss (NIHL). When present and otherwise unexplained, there is some controversy as to whether such asymmetry can be attributed to occupational noise exposure. In this review, our main objectives were to collate the overall prevalence of this finding in subjects with NIHL, and further, to provide a balanced argument regarding causality. DATA SOURCES: MEDLINE, CINAHL, EMBASE, Cochrane, Google Scholar...
September 2016: Otology & Neurotology
Xiangrong Xu, Qiuyue Yang, Jie Jiao, Lihua He, Shanfa Yu, Jingjing Wang, Guizhen Gu, Guoshun Chen, Wenhui Zhou, Hui Wu, Yanhong Li, Huanling Zhang
Noise-induced hearing loss (NIHL) is an important occupational disease worldwide resulting from interactions between genetic and environmental factors. The purpose of this study was to examine whether genetic variations in POU4F3 and GRHL2 may influence susceptibility to NIHL in the Chinese population. A matched case-control study was carried out among 293 hearing loss individuals and 293 normal hearing workers drawn from a population of 3790 noise-exposed workers. Ten single-nucleotide polymorphisms (SNPs) in POU4F3 and GRHL2 were selected and genotyped...
2016: International Journal of Environmental Research and Public Health
Jing Wang, Jun Li, Kang Peng, Zi-Ying Fu, Jia Tang, Ming-Jian Yang, Qi-Cai Chen
INTRODUCTION: Currently, there is limited information about the relationship between manganese superoxide dismutase (sod2) c47t polymorphism and susceptibility to noise-induced hearing loss (NIHL). OBJECTIVE: The aim of this meta-analysis was to clarify the association between SOD2 C47T polymorphism and NIHL. METHODS: A search in PubMed and Web of Science was performed to collect data. All full-text, English-written studies containing sufficient and complete case-and-control data about the relationship between SOD2 C47T polymorphism and NIHL were included...
April 19, 2016: Brazilian Journal of Otorhinolaryngology
A R Fetoni, S L M Eramo, F Paciello, R Rolesi, D Samengo, G Paludetti, D Troiani, G Pani
p66(shc), a member of the ShcA protein family, is essential for cellular response to oxidative stress, and elicits the formation of mitochondrial Reactive Oxygen Species (ROS), thus promoting vasomotor dysfunction and inflammation. Accordingly, mice lacking the p66 isoform display increased resistance to oxidative tissue damage and to cardiovascular disorders. Oxidative stress also contributes to noise-induced hearing loss (NIHL); we found that p66(shc) expression and serine phosphorylation were induced following noise exposure in the rat cochlea, together with markers of oxidative stress, inflammation and ischemia as indicated by the levels of the hypoxic inducible factor (HIF) and the vascular endothelial growth factor (VEGF) in the highly vascularised cochlear lateral region and spiral ganglion...
2016: Scientific Reports
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