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https://www.readbyqxmd.com/read/28918463/apoptotic-mechanisms-after-repeated-noise-trauma-in-the-mouse-medial-geniculate-body-and-primary-auditory-cortex
#1
Felix Fröhlich, Arne Ernst, Ira Strübing, Dietmar Basta, Moritz Gröschel
A correlation between noise-induced apoptosis and cell loss has previously been shown after a single noise exposure in the cochlear nucleus, inferior colliculus, medial geniculate body (MGB) and primary auditory cortex (AI). However, repeated noise exposure is the most common situation in humans and a major risk factor for the induction of noise-induced hearing loss (NIHL). The present investigation measured cell death pathways using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) in the dorsal, medial and ventral MGB (dMGB, mMGB and vMGB) and six layers of the AI (AI-1 to AI-6) in mice (NMRI strain) after a second noise exposure (double-exposure group)...
September 16, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28906242/safe-use-of-acoustic-vestibular-evoked-myogenic-potential-stimuli-protocol-and-patient-specific-considerations
#2
Cory D F Portnuff, Samantha Kleindienst, Jamie M Bogle
BACKGROUND: Vestibular-evoked myogenic potentials (VEMPs) are commonly used clinical assessments for patients with complaints of dizziness. However, relatively high air-conducted stimuli are required to elicit the VEMP, and ultimately may compromise safe noise exposure limits. Recently, research has reported the potential for noise-induced hearing loss (NIHL) from VEMP stimulus exposure through studies of reduced otoacoustic emission levels after VEMP testing, as well as a recent case study showing permanent sensorineural hearing loss associated with VEMP exposure...
September 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28885581/work-related-noise-exposure-in-a-cohort-of-patients-with-chronic-tinnitus-analysis-of-demographic-and-audiological-characteristics
#3
Massimo Ralli, Maria Paola Balla, Antonio Greco, Giancarlo Altissimi, Pasquale Ricci, Rosaria Turchetta, Armando de Virgilio, Marco de Vincentiis, Serafino Ricci, Giancarlo Cianfrone
Work-related noise exposure is one of the major factors contributing to the development of adult-onset hearing loss and tinnitus. The aim of this study was to analyze, in patients with chronic tinnitus and long-term occupational noise exposure, (A) characteristics of hearing loss, tinnitus, comorbidities, demographic characteristics and a history of work-related noise exposure and (B) differences among individuals employed in occupations with high and low risk of developing work-related noise-induced hearing loss (NIHL)...
September 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28747011/bioconversion-of-scutellaria-baicalensis-extract-can-increase-recovery-of-auditory-function-in-a-mouse-model-of-noise-induced-hearing-loss
#4
Isabel Rodriguez, Bin Na Hong, Youn Hee Nam, Eun Young Kim, Geun Ha Park, Min Gun Ji, Tong Ho Kang
In noise-induced hearing loss (NIHL), noise exposure damages cochlear sensory hair cells, which lack the capacity to regenerate. Following noise insult, intense metabolic activity occurs, resulting in a cochlear free radical imbalance. Oxidative stress and antioxidant enzyme alterations, including lipoxygenase upregulation, have been linked to chronic inflammation, which contributes to hearing impairment. We previously proposed Scutellaria baicalensis (SB) extract as an alternative therapeutic for preventing NIHL and attributed its pharmacological effects to baicalein...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738811/associations-of-genetic-variation-in-casp3-gene-with-noise-induced-hearing-loss-in-a-chinese-population-a-case-control-study
#5
Yinyin Wu, Juntao Ni, Mingjian Qi, Chengjian Cao, Yuxian Shao, Liangwen Xu, Haiyan Ma, Lei Yang
BACKGROUND: Noise-induced hearing loss (NIHL) is a complex disease caused by environmental and genetic risk factors. This study explored the relationship between the genetic variations in the CASP gene and the risk of developing NIHL among Chinese workers exposed to occupational noise. METHODS: A case-control study of 272 NIHL workers and 272 normal-hearing workers matched for age, sex and years of noise exposure was conducted. Fifteen single-nucleotide polymorphisms (SNP) in the CASP1, CASP3, CASP4, CASP5, CASP6, CASP8, CASP9, CASP10 and CASP14 genes were genotyped using the polymerase chain reaction-ligase detection reaction method...
July 24, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28649954/in-vitro-validation-of-coronary-ct-angiography-for-the-evaluation-of-complex-lesions
#6
Carlos Collet, Yoshinobu Onuma, Maik J Grundeken, Yosuke Miyazaki, Marcio Bittercourt, Pieter Kitslaar, Sadako Motoyama, Yukio Ozaki, Taku Asano, Jolanda J Wentzel, Geert J Streekstra, Patrick W Serruys, Robbert J de Winter, Nihls Planken
AIMS: To assess in vitro the diagnostic accuracy of computed tomography angiography (CTA) for the evaluation of complex coronary lesions. METHODS AND RESULTS: Five Plexiglas phantoms with three bifurcations lesions each were designed to mimic the anatomic variations and fractal phenomenon of the coronary tree. In addition, luminal stenosis were scaled up with increases of 10%. A third generation dual-source computed tomography was used. Automated quantitative CTA analysis was performed...
June 27, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28635495/analysis-of-audiometric-notch-as-a-noise-induced-hearing-loss-phenotype-in-us-youth-data-from-the-national-health-and-nutrition-examination-survey-2005-2010
#7
Ishan S Bhatt, O'neil Guthrie
OBJECTIVE: Bilateral audiometric notch (BN) at 4000-6000 Hz was identified as a noise-induced hearing loss (NIHL) phenotype for genetic association analysis in college-aged musicians. This study analysed BN in a sample of US youth. DESIGN: Prevalence of the BN within the study sample was determined and logistic-regression analyses were performed to identify audiologic and other demographic factors associated with BN. Computer-simulated "flat" audiograms were used to estimate potential influence of false-positive rates in estimating the prevalence of the BN...
February 8, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28549396/molecular-mechanisms-underlying-the-protective-effects-of-hydrogen-saturated-saline-on-noise-induced-hearing-loss
#8
Liwei Chen, Mingkun Han, Yan Lu, Daishi Chen, Xuejun Sun, Shiming Yang, Wei Sun, Ning Yu, Suoqiang Zhai
OBJECTIVES: This study aimed to explore the molecular mechanism of the protective effects of hydrogen-saturated saline on NIHL. METHODS: Guinea pigs were divided into three groups: hydrogen-saturated saline; normal saline; and control. For saline administration, the guinea pigs were given daily abdominal injections 3 d before and 1 h before noise exposure. ABR were tested to examine cochlear physiology changes. The changes of 8-hydroxy-desoxyguanosine (8-HOdG), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), intercellular cell adhesion molecule-1 (ICAM-1) and high mobility group box-1 protein (HMGB1) in the cochlea were also examined...
October 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28514024/historical-review-of-efforts-to-reduce-noise-induced-hearing-loss-in-the-united-states
#9
Madeleine J Kerr, Richard L Neitzel, OiSaeng Hong, Robert T Sataloff
BACKGROUND: Noise-induced hearing loss is a centuries-old problem that is still prevalent in the United States and worldwide. AIM: To describe highlights in the development of hearing loss prevention in the U.S. from World War II to the present. METHODS: Literature review. RESULTS: Approaches to occupational noise-induced hearing loss prevention in the United States over the past seven decades are described using a hierarchy of controls framework and an interdisciplinary perspective...
June 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28432353/severe-hearing-loss-and-outer-hair-cell-death-in-homozygous-foxo3-knockout-mice-after-moderate-noise-exposure
#10
Felicia Gilels, Stephen T Paquette, Holly J Beaulac, Anwen Bullen, Patricia M White
Noise induced hearing loss (NIHL) is a disease that affects millions of Americans. Identifying genetic pathways that influence recovery from noise exposure is an important step forward in understanding NIHL. The transcription factor Foxo3 integrates the cellular response to oxidative stress and plays a role in extending lifespan in many organisms, including humans. Here we show that Foxo3 is required for auditory function after noise exposure in a mouse model system, measured by ABR. Absent Foxo3, outer hair cells are lost throughout the middle and higher frequencies...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28422611/predictors-of-hearing-protection-use-among-industrial-workers
#11
Kunlayanee Tantranont, Nuntanat Codchanak
Promoting the use of hearing protection devices (HPDs) can prevent noise-induced hearing loss (NIHL) among workers who are exposed to excessive noise. In the present study, the authors examine factors that may explain HPD use among industrial workers from 15 manufacturing plants in Thailand. Participants consisted of 268 randomly selected workers exposed to harmful noise levels for which routine HPD use was required. Logistic regression analysis of study variables revealed the most powerful predictors of HPD use were perceived hearing status ( b = 0...
August 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/28420774/preventing-noise-induced-hearing-loss
#12
Julia Doswell Royster
Noise-induced hearing loss (NIHL) is second only to presbycusis, age-related hearing loss, as a cause of hearing impairment; yet, it is preventable. This commentary summarizes the effects of noise on hearing, relevant workplace regulations, and ways to minimize excessive noise's deleterious impact on individuals' quality of life on and off the job.
March 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28418325/variation-in-music-player-listening-level-as-a-function-of-campus-location
#13
Yunea Park, Diana Guercio, Victoria Ledon, Colleen G Le Prell
BACKGROUND: There has been significant discussion in the literature regarding music player use by adolescents and young adults, including whether device use is driving an increase in hearing loss in these populations. While many studies report relatively safe preferred listening levels, some studies with college student participants have reported listening habits that may put individuals at risk for noise-induced hearing loss (NIHL) if those listening habits continue over the long term...
April 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28397520/perceptions-of-public-primary-school-teachers-regarding-noise-induced-hearing-loss-in-south-africa
#14
Katerina Ehlert
BACKGROUND: Noise-induced hearing loss (NIHL) is an increasingly growing problem in young children. This is attributed to recreational noise being the most common cause of this problem. In young children, hearing problems can delay language development and reduce academic achievements. South Africa, in particular, has limited information and protective measures regarding the conservation of hearing in school-aged children. OBJECTIVES: The main aim of the study was to determine the perception of primary school teachers regarding NIHL...
March 28, 2017: South African Journal of Communication Disorders. die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings
https://www.readbyqxmd.com/read/28330550/-the-type-of-traumatic-sensorineural-hearing-loss-affects-diagnostic-and-medico-legal-assessment
#15
Steen Gimsing
Traumatic sensorineural hearing loss (TSHN) is mostly a high-frequency loss resembling noise-induced hearing loss (NIHL). However, approx. 25% of TSHN audiograms differ from NIHL in being of the slope, flat or low-frequency type. The physical properties of the trauma influence the audiogram shape, and the great individual variation of susceptibility to TSHN indicates the importance of genetic factors as well. As TSHN, like NIHL, predominantly is of a metabolic rather than a mechanical nature, its magnitude and configuration may change considerably during the first weeks after the causative incident...
March 20, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28306650/cochlear-transcriptome-following-acoustic-trauma-and-dexamethasone-administration-identified-by-a-combination-of-rna-seq-and-dna-microarray
#16
Yukihide Maeda, Ryotaro Omichi, Akiko Sugaya, Shin Kariya, Kazunori Nishizaki
AIM: To elucidate molecular mechanisms of noise-induced hearing loss (NIHL) and glucocorticoid therapy in the cochlea. BACKGROUND: Glucocorticoids are used to treat many forms of acute sensorineural hearing loss, but their molecular action in the cochlea remains poorly understood. METHODS: Dexamethasone was administered intraperitoneally immediately following acoustic overstimulation at 120 dB SPL for 2 hours to mice. The whole cochlear transcriptome was analyzed 12 and 24 hours following noise trauma and dexamethasone administration by both next-generation sequencing (RNA-seq) and DNA microarray...
August 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28292353/the-effect-of-pcdh15-gene-variations-on-the-risk-of-noise-induced-hearing-loss-in-a-chinese-population
#17
Xiang Rong Xu, Jing Jing Wang, Qiu Yue Yang, Jie Jiao, Li Hua He, Shan Fa Yu, Gui Zhen Gu, Guo Shun Chen, Wen Hui Zhou, Hui Wu, Yan Hong Li, Huan Ling Zhang, Zeng Rui Zhang, Xian Ning Jin
Noise-induced hearing loss (NIHL) is a complex disease caused by interactions between environmental and genetic factors. This study investigated whether genetic variability in protocadherin related 15 (PCDH15) underlies an increased susceptibility to the development of NIHL in a Chinese population. The results showed that compared with the TT genotype of rs11004085, CT/CC genotypes were associated with an increased risk of NIHL [adjusted odds ratio (OR) = 2.64; 95% confidence interval (CI): 1.14-6.11, P = 0...
February 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28241681/-association-between-cdh23-gene-polymorphisms-and-susceptibility-to-noise-induced-hearing-loss-in-the-chinese-population-a-meta-analysis
#18
J N Yu, S S Wu, C H He, C Y Zhang, H X Mu, W S Ma, B Liu, Y Zhang, S F Yu
Objective: To investigate the association between cadherin-23 (CDH23) gene polymorphisms and susceptibility to noise-induced hearing loss (NIHL) in the Chinese population through a meta-analysis. Methods: In June 2016, CNKI, VIP, Wanfang Data, and PubMed were searched for studies on the association between CDH23 gene polymorphisms and susceptibility to NIHL in the Chinese population. The articles were screened according to inclusion and exclusion criteria and related data were extracted. RevMan 5.3 was used for the meta-analysis...
December 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28241676/-influencing-factors-for-hearing-loss-in-workers-exposed-to-noise-in-a-cement-plant
#19
X M Wang, H Wu, J Jiao, Y H Li, Z R Zhang, W H Zhou, S F Yu
Objective: To investigate the incidence of noise-induced hearing loss (NIHL) and related influencing factors in workers exposed to noise in a cement plant. Methods: In October 2015, cluster sampling was used for questionnaire investigation and health examination of workers exposed to noise in a cement plant in Henan Province, China. The association of demographic features, living habits, cumulative noise exposure (CNE) , hypertension, and hyperlipidemia with NIHL was analyzed. Results: There was mainly medium-or high-frequency noise in the working place of this cement plant...
December 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28241675/-association-between-single-nucleotide-polymorphismsin-human-heat-shock-protein-70-gene-and-susceptibility-to-noise-induced-hearing-loss
#20
Y H Li, G S Chen, J Jiao, W H Zhou, H Wu, G Z Gu, H L Zhang, Y X Zheng, S F Yu
Objective: To investigate the association between the single nucleotide polymorphisms (SNPs) at rs1043618, rs2075800, and rs2763979 in human heat shock protein 70 (HSP70) gene and susceptibility to noise-induced hearing loss (NIHL) . Methods: A case-control study was performed, and 5 934 workers exposed to noise in an iron and steel plant in Henan, China, who underwent physical examination from 2006 to 2015, were enrolled as study subjects. According to the criteria of binaural average high - frequency (3000, 4000, and 6000 Hz) hearing threshold≥40 dB (HL) and monauralaverage speech-frequency (500, 1000, 2000 Hz) hearing threshold≥26 dB (HL) on the basis of binauralhigh frequency loss measured by pure tone audiometry, as well as the exclusion of NIHL, a total of 286 workers were enrolled as hearing loss group; after the adjustment for sex, type of work, age (difference≤5 years) , and working years of noise exposure (difference ≤2 years) , 286 workers were enrolled as control group...
December 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
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