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https://www.readbyqxmd.com/read/29747961/the-protective-effect-of-adrenocorticotropic-hormone-treatment-against-noise-induced-hearing-loss
#1
Ahmet Mutlu, Fatma Ceyda Akin Ocal, Seyra Erbek, Levent Ozluoglu
OBJECTIVE: NIHL is a common problem, and steroids are the most effective treatment option. In this study, we aimed to evaluate the protective effects of the synthetic adrenocorticotropic hormone (ACTH) analogues, which induce endogenous steroid secretion, against noise-induced hearing loss (NIHL) and to compare their effectiveness with that of steroid treatment. METHODS: Twenty-four male Sprague-Dawley albino rats were divided into four subgroups as follows: group 1 (n=6) control, group 2 (n=6) saline, group 3 (n=6) dexamethasone (2mg/kg/day intramuscularly [IM]), group 4 (n=6) ACTH analogue (0,4mg/kg/day IM), respectively...
May 7, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29743779/hearing-threshold-status-and-risk-estimate-of-hearing-impairment-among-administrative-workforce
#2
Joydeep Majumder, Ramanlal C Patel, Sanjay Kotadiya, Priyanka Shah
Background: Administrative workers working in quieter environment workplace are considered unaffected by noise-induced hearing loss (NIHL). Aim: To create a baseline data of the administrative workers so as to monitor them with prospective years of exposure with the hypothesis that workers working in the administrative jobs may not be affected by NIHL. Settings and Design: The study was conducted among men and women administrative workers working in an office in Ahmedabad city, India...
January 2018: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29716271/supra-aural-transducer-related-artifact-contributes-to-overestimation-of-noise-induced-hearing-loss
#3
Ishan S Bhatt
This study compared the effects of supra-aural and insert receivers on the prevalence of noise-induced hearing loss (NIHL) in young adults. NIHL prevalence was found to be substantially higher when hearing thresholds were obtained with supra-aural compared to insert receivers on the same subjects. Real-ear sound pressure levels at 4000, 6000, and 8000 Hz were the major predictors of notched-audiograms obtained with supra-aural headphones. Distortion-product otoacoustic emissions were not significantly different between ears with and without notched-audiograms obtained with supra-aural headphones...
April 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29675997/hearing-vulnerability-after-noise-exposure-in-a-mouse-model-of-reactive-oxygen-species-overproduction
#4
Shigefumi Morioka, Hirofumi Sakaguchi, Taro Yamaguchi, Yuzuru Ninoyu, Hiroaki Mohri, Takashi Nakamura, Yasuo Hisa, Kiyokazu Ogita, Naoaki Saito, Takehiko Ueyama
Previous studies have convincingly argued that reactive oxygen species (ROS) contribute to the development of several major types of sensorineural hearing loss, such as noise-induced hearing loss (NIHL), drug-induced hearing loss, and age-related hearing loss. However, the underlying molecular mechanisms induced by ROS in these pathologies remain unclear. To resolve this issue, we established an in vivo model of ROS overproduction by generating a transgenic (TG) mouse line expressing the human NADPH oxidase 4 (NOX4, NOX4-TG mice), which is a constitutively active ROS-producing enzyme that does not require stimulation or an activator...
April 20, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29673641/a-novel-nanoparticle-delivery-system-for-targeted-therapy-of-noise-induced-hearing-loss
#5
Mohammad N Kayyali, Julian R A Wooltorton, Andrew J Ramsey, Mei Lin, Tiffany N Chao, Andrew Tsourkas, Bert W O'Malley, Daqing Li
Hearing loss is the most prevalent sensory disability worldwide and may be caused by age, drugs or exposure to excessive noise. We have previously developed a minimally-invasive nanohydrogel drug delivery system that successfully delivers nanoparticles into the inner ear. We have substantially extended this technique by functionalizing the nanoparticles and introducing a targeting peptide which recognizes prestin, a transmembrane electromotile protein uniquely expressed in outer hair cells (OHCs) of the inner ear...
April 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29530094/the-impact-of-biological-sex-on-the-response-to-noise-and-otoprotective-therapies-against-acoustic-injury-in-mice
#6
Béatrice Milon, Sunayana Mitra, Yang Song, Zachary Margulies, Ryan Casserly, Virginia Drake, Jessica A Mong, Didier A Depireux, Ronna Hertzano
BACKGROUND: Noise-induced hearing loss (NIHL) is the most prevalent form of acquired hearing loss and affects about 40 million US adults. Among the suggested therapeutics tested in rodents, suberoylanilide hydroxamic acid (SAHA) has been shown to be otoprotective from NIHL; however, these results were limited to male mice. METHODS: Here we tested the effect of SAHA on the hearing of 10-week-old B6CBAF1/J mice of both sexes, which were exposed to 2 h of octave-band noise (101 dB SPL centered at 11...
March 12, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/29456958/etiology-of-noise-induced-hearing-loss-nihl-and-its-symptomatic-correlation-with-audiometry-observations-in-type-ii-diabetes
#7
Meena K Yadav, K S Yadav
Type II diabetic mellitus (DM) is a chronic metabolic disease that impairs normal insulin production and glucose transport to the liver and muscles. In the India, about 1-5% population suffer from diabetes or related complication. So there is need to cure this disease. DM chronic auditory complications may include spiral ganglia atrophy, degeneration of the vestibulocochlear nerve myelin sheath, reduction of the number of spiral lamina nerve fibres, and thickening of the capillary walls of the stria vascularis and small arteries...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29451220/critical-role-of-sdf-1-cxcr4-signaling-pathway-in-stem-cell-homing-in-the-deafened-rat-cochlea-after-acoustic-trauma
#8
Ali Asghar Peyvandi, Navid Ahmady Roozbahany, Hassan Peyvandi, Hojjat-Allah Abbaszadeh, Niloofar Majdinasab, Mohammad Faridan, Somayeh Niknazar
Previous animal studies have shown that stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) signaling pathway plays an important role in the targeted migration of bone marrow-derived mesenchymal stem cells (BMSCs) to the injured area. In the present study, we aimed to investigate the potential role of chemotactic SDF-1/CXCR4 signaling pathway in the homing of transplanted BMSCs to the injured cochlea after noise-induced hearing loss (NIHL) in a rat model. White noise exposure (110 dB) paradigm was used for hearing loss induction in male rats for 6 hours in 5 days...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29371894/the-effect-of-the-cholesterol-levels-on-noise-induced-hearing-loss
#9
Mehmet Gokhan Demir, Sedat Aydin
Introduction  Noise-induced hearing loss (NIHL), which is one of the most common occupational diseases among industrialized populations, is associated with longstanding exposure to high levels of noise. The pathogenesis of NIHL is not clear, but some genes and their activity at the tissue level have been investigated. Hypercholesterolemia, which can disturb the microcirculation, can be one of the underlying pathologies in hearing loss. Objective  To investigate the relationship between NIHL and hypercholesterolemia...
January 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29328791/how-noisy-are-total-knee-and-hip-replacements
#10
Jonathan P Simpson, Andrew J Hamer
Orthopaedic theatre can be noisy. Fifty percent of orthopaedic theatre staff have features of noise-induced hearing loss (NIHL). In this study, decibel (dB) levels were recorded in 17 total knee replacements (TKRs) and 11 total hip replacements (THRs). Noise levels reached 105.6dB(A) using a hammer and 97.9dB(A) with an oscillating saw. Exposure to levels above 90dB (which occurred in every case) even for short time periods is proven to cause irreversible loss of hearing. Tools used in orthopaedic theatre produce impulse noises that can cause NIHL...
December 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29317248/cognitive-decline-and-increased-hippocampal-p-tau-expression-in-mice-with-hearing-loss
#11
So Young Park, Min Jung Kim, Hong Lim Kim, Dong Kee Kim, Sang Won Yeo, Shi Nae Park
Hearing and cognition are commonly involved in both normal and pathological aging. Current clinical interest lies in whether peripheral hearing loss promotes cognitive decline. In our previous publication, the authors have shown a causal relationship between hearing and cognitive impairments in C57BL/6 mice. Here we extended the follow-up to 12 months to determine the long-term effects of hearing loss on cognition and to observe hippocampal p-tau and lipofuscin. One month old male mice were randomly allocated into two groups, the control (n = 12) and noise-induced hearing loss (NIHL) (n = 12)...
April 16, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29301492/effect-of-grm7-polymorphisms-on-the-development-of-noise-induced-hearing-loss-in-chinese-han-workers-a-nested-case-control-study
#12
Peipei Yu, Jie Jiao, Guoshun Chen, Wenhui Zhou, Huanling Zhang, Hui Wu, Yanhong Li, Guizhen Gu, Yuxin Zheng, Yue Yu, Shanfa Yu
BACKGROUND: Noise-induced hearing loss (NIHL) is a complex, irreversible disease caused by the interaction of genetic and environmental factors. In recent years, a great many studies have been done to explore the NIHL susceptibility genes among humans. So far, high powerful detections have been founded that genes of potassium ion channel genes (KCNQ4 and KCNE1), catalase (CAT), protocadherin 15 (PCDH15), myosin 14 (MYH14) and heart shock protein (HSP70) which have been identified in more than one population may be associated with the susceptibility to NIHL...
January 5, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29220389/association-of-genetic-variations-in-foxo3-gene-with-susceptibility-to-noise-induced-hearing-loss-in-a-chinese-population
#13
Haoran Guo, Enmin Ding, Ying Bai, Hengdong Zhang, Huanxi Shen, Jun Wang, Xianping Song, Wenyan Cai, Jiadi Guo, Baoli Zhu
Noise induced hearing loss (NIHL), a multifactorial disease involving both genetic and environmental factors, is one of the most important occupational health hazards. Nonetheless, the influence of FOXO3 variants on NIHL risk have not been illuminated. This research was conducted to explore the effects of FOXO3 polymorphisms on individual susceptibility to NIHL. A total of 2689 industrial workers from one textile factory of east China were recruited to participate in the current research. Venous blood was collected, questionnaire and pure-tone audiometry (PTA) was conducted by specialist physicians...
2017: PloS One
https://www.readbyqxmd.com/read/29216778/costs-and-effectiveness-of-hearing-conservation-programs-at-14-us-metal-manufacturing-facilities
#14
Stephanie K Sayler, Peter M Rabinowitz, Linda F Cantley, Deron Galusha, Richard L Neitzel
OBJECTIVE: This study characterised overall and specific costs associated with hearing conservation programmes (HCPs) at US metal manufacturing sites, and examined the association between these costs and several noise-induced hearing loss (NIHL) outcomes. DESIGN: We interviewed personnel and reviewed records at participating facilities. We also measured noise for comparison to the ten-year average of measurements made by each facility. NIHL outcomes assessed included rates of standard threshold shifts (STS) and high-frequency hearing loss, as well as prevalence of hearing impairment, for each participating facility...
February 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29176785/association-between-polymorphisms-of-heat-shock-protein-70-genes-and-noise-induced-hearing-loss-a-meta-analysis
#15
Song Lei, Liu Huang, Yaqian Liu, Liangwen Xu, Dahui Wang, Lei Yang
BACKGROUND: Recent studies have evaluated the associations between polymorphisms of the heat-shock protein 70 (HSP70) encoding genes and noise-induced hearing loss (NIHL). However, the conclusions of these studies are conflicting. The objective of this meta-analysis was to clarify the association between all known polymorphisms of HSP70 genetic loci and susceptibility to NIHL, based on existing reports. METHODS: We conducted a meta-analysis of the association between Hsp70 polymorphisms (rs1043618, rs1061581, rs2075800, rs2227956, and rs2763979) and NIHL risk in both Chinese and Caucasian males...
2017: PloS One
https://www.readbyqxmd.com/read/29172785/examining-the-noisy-life-of-the-college-musician-weeklong-noise-dosimetry-of-music-and-non-music-activities
#16
Jennifer B Tufts, Erika Skoe
OBJECTIVE: To examine the contribution of all daily activities, including non-music activities, to the overall noise exposure of college student musicians, and to compare their "noise lives" with those of non-musician college students. DESIGN: Continuous week-long dosimetry measurements were collected on student musicians and non-musicians. During the measurement period, participants recorded their daily activities in journals. STUDY SAMPLE: 22 musicians and 40 non-musicians, all students (aged 18-24 years) at the University of Connecticut...
February 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29145455/association-of-polymorphisms-in-heat-shock-protein-70-genes-with-the-susceptibility-to-noise-induced-hearing-loss-a-meta-analysis
#17
Shimin Zong, Xue Zeng, Tianyi Liu, Fangmin Wan, Pan Luo, Hongjun Xiao
BACKGROUND: Several case-control studies reported the relationship between single nucleotide polymorphisms (SNPs) in HSP70 genes and noise-induced hearing loss (NIHL). However, their conclusions are conflicting. This meta-analysis aims to identify the association of HSP70 variants and NIHL susceptibility. METHOD: A systematical literature search was performed in PubMed, Web of Science, EMBASE, and Wanfang Chinese database. The pooled odds radio (OR), 95% confidence interval (CI) and p value were calculated in fixed- or random-effects model according to the I2 value in the heterogeneity test...
2017: PloS One
https://www.readbyqxmd.com/read/29119679/noise-induced-hearing-loss-an-examination-of-the-methods-of-assessment-in-a-cross-sectional-study-of-87-industrial-workers
#18
S Das, M Mulheran, M Brewster, A R Banerjee
OBJECTIVES: The surveillance of noise-induced hearing loss (NIHL) according to the Health and Safety Executive (HSE) differs from the medico-legal criteria used to assess NIHL. Our study compares the two systems and proposes a novel method of simplifying the medico-legal criteria and applying it to ascertain noise-induced hearing loss. DESIGN: The anonymised audiograms of a group of 87 industrial workers from a single site were analysed with both methods. RESULTS: The comparison showed approximately one-third of the workers assessed in this study had their noise-induced hearing loss underestimated by the HSE criteria...
April 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29116045/contemporary-noise-induced-hearing-loss-nihl-prevention
#19
Wiesław Sułkowski, Kalina Owczarek, Jurek Olszewski
Hearing impairment caused by noise, traditionally called - depending on the duration of exposure - acute or chronic acoustic trauma, includes, in addition to presbyacusis, the most common adult population of hearing impaired. In Poland - according to the report of the Central Statistical Office (GUS, 2011), the number of workers employed in NDN exceeded the noise level (85 dB) is about 200 thousand, the highest in the mining, metal and metal products production, textiles and wood production. According to the Regulation of the Council of Ministers of on June 30, 2009, on the list of occupational diseases (Journal of Laws No...
August 31, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29058570/occupational-noise-exposure-and-hearing-defects-among-sawmill-workers-in-the-south-of-thailand
#20
Phayong Thepaksorn, Akio Koizumi, Kouji Harada, Wattasit Siriwong, Richard L Neitzel
The aim of this study was to investigate occupational noise exposure and hearing defects among sawmill workers in the south of Thailand. Seven hundred sawmill workers participated, of which 335 (47.9%) were male. The mean age of the sawmill workers was 33.5 years (SD 10.2), and more than 60% were <35 years old; 75.1% of the workers had less than 5 years of work experience. Only about one in four workers (25%) had been trained in use of personal protective equipment (PPE), and half of the participants never or rarely wore PPE while working...
January 19, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
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