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https://www.readbyqxmd.com/read/28330550/-the-type-of-traumatic-sensorineural-hearing-loss-affects-diagnostic-and-medico-legal-assessment
#1
Steen Gimsing
Traumatic sensorineural hearing loss (TSHN) is mostly a high-frequency loss resembling noise-induced hearing loss (NIHL). However, approx. 25% of TSHN audiograms differ from NIHL in being of the slope, flat or low-frequency type. The physical properties of the trauma influence the audiogram shape, and the great individual variation of susceptibility to TSHN indicates the importance of genetic factors as well. As TSHN, like NIHL, predominantly is of a metabolic rather than a mechanical nature, its magnitude and configuration may change considerably during the first weeks after the causative incident...
March 20, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28306650/cochlear-transcriptome-following-acoustic-trauma-and-dexamethasone-administration-identified-by-a-combination-of-rna-seq-and-dna-microarray
#2
Yukihide Maeda, Ryotaro Omichi, Akiko Sugaya, Shin Kariya, Kazunori Nishizaki
AIM: To elucidate molecular mechanisms of noise-induced hearing loss (NIHL) and glucocorticoid therapy in the cochlea. BACKGROUND: Glucocorticoids are used to treat many forms of acute sensorineural hearing loss, but their molecular action in the cochlea remains poorly understood. METHODS: Dexamethasone was administered intraperitoneally immediately following acoustic overstimulation at 120 dB SPL for 2 hours to mice. The whole cochlear transcriptome was analyzed 12 and 24 hours following noise trauma and dexamethasone administration by both next-generation sequencing (RNA-seq) and DNA microarray...
March 16, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28292353/the-effect-of-pcdh15-gene-variations-on-the-risk-of-noise-induced-hearing-loss-in-a-chinese-population
#3
Xiang Rong Xu, Jing Jing Wang, Qiu Yue Yang, Jie Jiao, Li Hua He, Shan Fa Yu, Gui Zhen Gu, Guo Shun Chen, Wen Hui Zhou, Hui Wu, Yan Hong Li, Huan Ling Zhang, Zeng Rui Zhang, Xian Ning Jin
Noise-induced hearing loss (NIHL) is a complex disease caused by interactions between environmental and genetic factors. This study investigated whether genetic variability in protocadherin related 15 (PCDH15) underlies an increased susceptibility to the development of NIHL in a Chinese population. The results showed that compared with the TT genotype of rs11004085, CT/CC genotypes were associated with an increased risk of NIHL [adjusted odds ratio (OR) = 2.64; 95% confidence interval (CI): 1.14-6.11, P = 0...
February 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28241681/-association-between-cdh23-gene-polymorphisms-and-susceptibility-to-noise-induced-hearing-loss-in-the-chinese-population-a-meta-analysis
#4
J N Yu, S S Wu, C H He, C Y Zhang, H X Mu, W S Ma, B Liu, Y Zhang, S F Yu
Objective: To investigate the association between cadherin-23 (CDH23) gene polymorphisms and susceptibility to noise-induced hearing loss (NIHL) in the Chinese population through a meta-analysis. Methods: In June 2016, CNKI, VIP, Wanfang Data, and PubMed were searched for studies on the association between CDH23 gene polymorphisms and susceptibility to NIHL in the Chinese population. The articles were screened according to inclusion and exclusion criteria and related data were extracted. RevMan 5.3 was used for the meta-analysis...
December 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28241676/-influencing-factors-for-hearing-loss-in-workers-exposed-to-noise-in-a-cement-plant
#5
X M Wang, H Wu, J Jiao, Y H Li, Z R Zhang, W H Zhou, S F Yu
Objective: To investigate the incidence of noise-induced hearing loss (NIHL) and related influencing factors in workers exposed to noise in a cement plant. Methods: In October 2015, cluster sampling was used for questionnaire investigation and health examination of workers exposed to noise in a cement plant in Henan Province, China. The association of demographic features, living habits, cumulative noise exposure (CNE) , hypertension, and hyperlipidemia with NIHL was analyzed. Results: There was mainly medium-or high-frequency noise in the working place of this cement plant...
December 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28241675/-association-between-single-nucleotide-polymorphismsin-human-heat-shock-protein-70-gene-and-susceptibility-to-noise-induced-hearing-loss
#6
Y H Li, G S Chen, J Jiao, W H Zhou, H Wu, G Z Gu, H L Zhang, Y X Zheng, S F Yu
Objective: To investigate the association between the single nucleotide polymorphisms (SNPs) at rs1043618, rs2075800, and rs2763979 in human heat shock protein 70 (HSP70) gene and susceptibility to noise-induced hearing loss (NIHL) . Methods: A case-control study was performed, and 5 934 workers exposed to noise in an iron and steel plant in Henan, China, who underwent physical examination from 2006 to 2015, were enrolled as study subjects. According to the criteria of binaural average high - frequency (3000, 4000, and 6000 Hz) hearing threshold≥40 dB (HL) and monauralaverage speech-frequency (500, 1000, 2000 Hz) hearing threshold≥26 dB (HL) on the basis of binauralhigh frequency loss measured by pure tone audiometry, as well as the exclusion of NIHL, a total of 286 workers were enrolled as hearing loss group; after the adjustment for sex, type of work, age (difference≤5 years) , and working years of noise exposure (difference ≤2 years) , 286 workers were enrolled as control group...
December 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28241674/-association-between-serum-magnesium-ion-level-and-risk-of-noise-induced-hearing-loss
#7
J Jiao, G Z Gu, G S Chen, Y X Zheng, H L Zhang, Q Geng, Y B Cheng, S F Yu
Objective: To investigate the association between serum magnesium ion level and risk of noise-induced hearing loss (NIHL) . Methods: Acohort study was performed for 7 445 workers exposed to noise in the steelmaking and steel rolling workshops of an iron and steel enterprise in Henan Province, China. The follow-up time was from January 1, 2006 to December 31, 2015. The workers with a binaural average high-frequency hearing threshold of ≥40 dB (HL) were enrolled as case group, and those with a binaural average high-frequency hearing threshold of <35 dB (HL) and a binaural average speech frequency of ≤25 dB (HL) were enrolled as control group...
December 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28223190/association-of-tagsnp-in-lncrna-hotair-with-susceptibility-to-noise-induced-hearing-loss-in-a-chinese-population
#8
Boshen Wang, Enmin Ding, Huanxi Shen, Jianfeng Wang, Kai Sun, Shi Chen, Lei Han, Hengdong Zhang, Baoli Zhu, Ming Xu
BACKGROUND: Noise-induced hearing loss (NIHL) is a multifactorial disease, and dysregulation of oxidative stress is universally acknowledged as one crucial pathogenic factor for this disease. Recently studies have found the LncRNA HOTAIR is involved in the alteration of oxidative stress level, cell proliferation, cell cycle progression, and apoptosis. Considering the effects of lncRNA HOTAIR in cellular oxidative stress, we sought to investigate the influence of lncRNA HOTAIR variants on the risk of NIHL...
February 18, 2017: Hearing Research
https://www.readbyqxmd.com/read/28220907/exposure-to-excessive-sounds-and-hearing-status-in-academic-classical-music-students
#9
Małgorzata Pawlaczyk-Łuszczyńska, Małgorzata Zamojska-Daniszewska, Adam Dudarewicz, Kamil Zaborowski
OBJECTIVES: The aim of this study was to assess hearing of music students in relation to their exposure to excessive sounds. MATERIAL AND METHODS: Standard pure-tone audiometry (PTA) was performed in 168 music students, aged 22.5±2.5 years. The control group included 67 subjects, non-music students and non-musicians, aged 22.8±3.3 years. Data on the study subjects' musical experience, instruments in use, time of weekly practice and additional risk factors for noise-induced hearing loss (NIHL) were identified by means of a questionnaire survey...
February 21, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28194422/pharmacokinetic-properties-of-adenosine-amine-congener-in-cochlear-perilymph-after-systemic-administration
#10
Hao Chang, Ravindra S Telang, Sreevalsan Sreebhavan, Malcolm Tingle, Peter R Thorne, Srdjan M Vlajkovic
Noise-induced hearing loss (NIHL) is a global health problem affecting over 5% of the population worldwide. We have shown previously that acute noise-induced cochlear injury can be ameliorated by administration of drugs acting on adenosine receptors in the inner ear, and a selective A1 adenosine receptor agonist adenosine amine congener (ADAC) has emerged as a potentially effective treatment for cochlear injury and resulting hearing loss. This study investigated pharmacokinetic properties of ADAC in rat perilymph after systemic (intravenous) administration using a newly developed liquid chromatography-tandem mass spectrometry detection method...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28182740/polymorphisms-of-heat-shock-protein-70-genes-hspa1a-hspa1b-and-hspa1l-and-susceptibility-of-noise-induced-hearing-loss-in-a-chinese-population-a-case-control-study
#11
Yanhong Li, Shanfa Yu, Guizhen Gu, Guoshun Chen, Yuxin Zheng, Jie Jiao, Wenhui Zhou, Hui Wu, Zengrui Zhang, Huanling Zhang, Lihua He, Qiuyue Yang, Xiangrong Xu
Noise-induced hearing loss (NIHL) is the second-most frequent form of sensorineural hearing loss. When exposed to the same noise, some workers develop NIHL while others do not, suggesting that NIHL may be associated with genetic factors. To explore the relationship between single nucleotide polymorphisms (SNPs) in heat shock protein 70 (HSP70) genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility to NIHL in Han Chinese workers exposed to noise, a case-control association study was carried out with 286 hearing loss cases and 286 matched with gender, age, type of work, and exposure time, drawn from a population of 3790 noise-exposed workers...
2017: PloS One
https://www.readbyqxmd.com/read/28163078/manganese-superoxide-dismutase-influences-the-extent-of-noise-induced-hearing-loss-in-mice
#12
Ayinuer Tuerdi, Makoto Kinoshita, Teru Kamogashira, Chisato Fujimoto, Shinnichi Iwasaki, Takahiko Shimizu, Tatsuya Yamasoba
Reactive oxygen species (ROS) generation is one of the mechanisms underlying noise-induced hearing loss (NIHL). Manganese superoxide dismutase (Mn-SOD), an antioxidant enzyme acting within the mitochondria, converts toxic superoxide to hydrogen peroxide. We investigated the role of Mn-SOD in NIHL by examining the extent of hearing loss and hair cell damage after noise exposure in C57BL/6 wild-type (WT) mice and Mn-SOD heterozygous knockout (HET) mice (n=6 each). Both HET and WT mice were exposed to 120dB sound pressure level at 4kHz octave band noise for 4h...
March 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28125313/effects-of-early-intratympanic-steroid-injection-in-patients-with-acoustic-trauma-caused-by-gunshot-noise
#13
Young-Soo Chang, Kang Hyun Bang, Byoungseo Jeong, Gang-Gyu Lee
CONCLUSION: This study evaluated the efficacy of concurrent administration of ITSI and systemic steroids in delayed treatment of NIHL after gunshot noise exposure. The results showed additional hearing benefits with administration of ITSI. Further evaluation is warranted to confirm this efficacy. OBJECTIVE: This investigation evaluated the effects of early administration of an intratympanic steroid injection (ITSI) in combination with systemic steroids treatment in patients with acoustic trauma caused by gunshot noise...
January 26, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28094540/examining-mechanisms-underlying-fear-control-in-the-extended-parallel-process-model
#14
Brian L Quick, Nicole R LaVoie, Tobias Reynolds-Tylus, Andrea Martinez-Gonzalez, Chris Skurka
This investigation sought to advance the extended parallel process model in important ways by testing associations among the strengths of efficacy and threat appeals with fear as well as two outcomes of fear-control processing, psychological reactance and message minimization. Within the context of print ads admonishing against noise-induced hearing loss (NIHL) and the fictitious Trepidosis virus, partial support was found for the additive model with no support for the multiplicative model. High efficacy appeals mitigated freedom threat perceptions across both contexts...
January 17, 2017: Health Communication
https://www.readbyqxmd.com/read/28077280/engineering-out-the-noise
#15
Kurt Yankaskas, Raymond Fischer, Jesse Spence, Jeff Komrower
The US Navy, through an Office of Naval Research (ONR) lead effort on Noise Induced Hearing Loss (NIHL), is investigating methods and techniques to mitigate hearing loss for the crews and warfighters. Hearing protection is a viable and increasingly popular method of reducing hearing exposure for many ship crewmembers; however, it has limitations on comfort and low frequency effectiveness. Furthermore, Personal Hearing Protection (PHP) is often used improperly. Proper vessel planning, programmatic changes and advances in noise control engineering can also have significant impacts by inherently reducing noise exposure through ship design and use of noise control treatments...
January 7, 2017: Hearing Research
https://www.readbyqxmd.com/read/28056268/-investigation-into-the-relationship-between-mitochondrial-12-s-rrna-gene-trna-gene-and-cytochrome-oxidase-%C3%A2-gene-variations-and-the-risk-of-noise-induced-hearing-loss
#16
J Jiao, G Z Gu, G S Chen, Y H Li, H L Zhang, Q Y Yang, X R Xu, W H Zhou, H Wu, L H He, Y X Zheng, S F Yu
Objective: To explore the relationship between mitochondrial 12 S rRNA gene variation, tRNA gene variation and cytochrome oxidase Ⅱ gene point mutations and the risk of noise-induced hearing loss (NIHL). Methods: A nested case-control study was performed that followed a cohort of 7 445 noise-exposed workers in a steel factory in Henan province, China, from January 1, 2006 to December 31, 2015. Subjects whose average hearing threshold was more than 40 dB(A) in high frequency were defined as the case group, and subjects whose average hearing threshold was less than 35 dB(A) in high frequency and less than 25 dB (A) in speech frequency were defined as the control group...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28056267/-association-between-eye-absent-homolog-4-gene-polymorphisms-and-occupational-noise-induced-hearing-loss
#17
Q Y Yang, X R Xu, J Jiao, Y X Zheng, L H He, S F Yu, G Z Gu, G S Chen, W H Zhou, H Wu, Y H Li, H L Zhang, Z R Zhang
Objective: To identify the association between genetic polymorphisms in the eye absent homolog 4 (EYA4) gene and noise-induced hearing loss (NIHL). Method: A nested case control study was conducted based on a cohort of noise-exposed subjects. In total, 292 cases were selected from a steel factory from 6 297 subjects during Jan 1, 2006 to Dec 12, 2015,who had an average hearing threshold of more than 40 dB(A); 584 matched control subjects for each case were designated on the basis of matched criteria including same gender, age (±5 years) and duration of exposure to noise (±2 years)...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28056266/-association-between-variations-in-protocadherin-15-gene-and-occupational-noise-induced-hearing-loss
#18
X R Xu, Q Y Yang, J Jiao, Y X Zheng, L H He, S F Yu, G Z Gu, G S Chen, W H Zhou, H Wu, Y H Li, H L Zhang, Z R Zhang
Objective: The aim of this study was to investigate whether genetic variability in the protocadherin 15 (PCDH15) gene may correspond with increased susceptibility to noise-induced hearing loss (NIHL) in a Chinese population. Methods: A nested case-control study was performed that followed a cohort of 7 445 noise-exposed workers in a steel factory of Henan province in China from January 1, 2006 to December 31, 2015. In this study, 394 cases who had an average hearing threshold of more than 40 dB (A) in high frequency were defined as the case group, and 721 controls who had an average hearing threshold of less than 35 dB (A) in high frequency and less than 25 dB (A) in speech frequency were defined as the control group...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28054909/noise-exposure-questionnaire-a-tool-for-quantifying-annual-noise-exposure
#19
Tiffany A Johnson, Susan Cooper, Greta C Stamper, Mark Chertoff
BACKGROUND: Exposure to both occupational and nonoccupational noise is recognized as a risk factor for noise-induced hearing loss (NIHL). Although audiologists routinely inquire regarding history of noise exposure, there are limited tools available for quantifying this history or for identifying those individuals who are at highest risk for NIHL. Identifying those at highest risk would allow hearing conservation activities to be focused on those individuals. PURPOSE: To develop a detailed, task-based questionnaire for quantifying an individual's annual noise exposure (ANE) arising from both occupational and nonoccupational sources (aim 1) and to develop a short screening tool that could be used to identify individuals at high risk of NIHL (aim 2)...
January 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28034617/cochlear-hair-cell-regeneration-after-noise-induced-hearing-loss-does-regeneration-follow-development
#20
REVIEW
Fei Zheng, Jian Zuo
Noise-induced hearing loss (NIHL) affects a large number of military personnel and civilians. Regenerating inner-ear cochlear hair cells (HCs) is a promising strategy to restore hearing after NIHL. In this review, we first summarize recent transcriptome profile analysis of zebrafish lateral lines and chick utricles where spontaneous HC regeneration occurs after HC damage. We then discuss recent studies in other mammalian regenerative systems such as pancreas, heart and central nervous system. Both spontaneous and forced HC regeneration occurs in mammalian cochleae in vivo involving proliferation and direct lineage conversion...
December 26, 2016: Hearing Research
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