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Béatrice Milon, Sunayana Mitra, Yang Song, Zachary Margulies, Ryan Casserly, Virginia Drake, Jessica A Mong, Didier A Depireux, Ronna Hertzano
BACKGROUND: Noise-induced hearing loss (NIHL) is the most prevalent form of acquired hearing loss and affects about 40 million US adults. Among the suggested therapeutics tested in rodents, suberoylanilide hydroxamic acid (SAHA) has been shown to be otoprotective from NIHL; however, these results were limited to male mice. METHODS: Here we tested the effect of SAHA on the hearing of 10-week-old B6CBAF1/J mice of both sexes, which were exposed to 2 h of octave-band noise (101 dB SPL centered at 11...
March 12, 2018: Biology of Sex Differences
Meena K Yadav, K S Yadav
Type II diabetic mellitus (DM) is a chronic metabolic disease that impairs normal insulin production and glucose transport to the liver and muscles. In the India, about 1-5% population suffer from diabetes or related complication. So there is need to cure this disease. DM chronic auditory complications may include spiral ganglia atrophy, degeneration of the vestibulocochlear nerve myelin sheath, reduction of the number of spiral lamina nerve fibres, and thickening of the capillary walls of the stria vascularis and small arteries...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
Ali Asghar Peyvandi, Navid Ahmady Roozbahany, Hassan Peyvandi, Hojjat-Allah Abbaszadeh, Niloofar Majdinasab, Mohammad Faridan, Somayeh Niknazar
Previous animal studies have shown that stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) signaling pathway plays an important role in the targeted migration of bone marrow-derived mesenchymal stem cells (BMSCs) to the injured area. In the present study, we aimed to investigate the potential role of chemotactic SDF-1/CXCR4 signaling pathway in the homing of transplanted BMSCs to the injured cochlea after noise-induced hearing loss (NIHL) in a rat model. White noise exposure (110 dB) paradigm was used for hearing loss induction in male rats for 6 hours in 5 days...
January 2018: Neural Regeneration Research
Mehmet Gokhan Demir, Sedat Aydin
Introduction  Noise-induced hearing loss (NIHL), which is one of the most common occupational diseases among industrialized populations, is associated with longstanding exposure to high levels of noise. The pathogenesis of NIHL is not clear, but some genes and their activity at the tissue level have been investigated. Hypercholesterolemia, which can disturb the microcirculation, can be one of the underlying pathologies in hearing loss. Objective  To investigate the relationship between NIHL and hypercholesterolemia...
January 2018: International Archives of Otorhinolaryngology
Jonathan P Simpson, Andrew J Hamer
Orthopaedic theatre can be noisy. Fifty percent of orthopaedic theatre staff have features of noise-induced hearing loss (NIHL). In this study, decibel (dB) levels were recorded in 17 total knee replacements (TKRs) and 11 total hip replacements (THRs). Noise levels reached 105.6dB(A) using a hammer and 97.9dB(A) with an oscillating saw. Exposure to levels above 90dB (which occurred in every case) even for short time periods is proven to cause irreversible loss of hearing. Tools used in orthopaedic theatre produce impulse noises that can cause NIHL...
December 2017: Journal of Perioperative Practice
So Young Park, Min Jung Kim, Hong Lim Kim, Dong Kee Kim, Sang Won Yeo, Shi Nae Park
Hearing and cognition are commonly involved in both normal and pathological aging. Current clinical interest lies in whether peripheral hearing loss promotes cognitive decline. In our previous publication, the authors have shown a causal relationship between hearing and cognitive impairments in C57BL/6 mice. Here we extended the follow-up to 12 months to determine the long-term effects of hearing loss on cognition and to observe hippocampal p-tau and lipofuscin. One month old male mice were randomly allocated into two groups, the control (n = 12) and noise-induced hearing loss (NIHL) (n = 12)...
January 6, 2018: Behavioural Brain Research
Peipei Yu, Jie Jiao, Guoshun Chen, Wenhui Zhou, Huanling Zhang, Hui Wu, Yanhong Li, Guizhen Gu, Yuxin Zheng, Yue Yu, Shanfa Yu
BACKGROUND: Noise-induced hearing loss (NIHL) is a complex, irreversible disease caused by the interaction of genetic and environmental factors. In recent years, a great many studies have been done to explore the NIHL susceptibility genes among humans. So far, high powerful detections have been founded that genes of potassium ion channel genes (KCNQ4 and KCNE1), catalase (CAT), protocadherin 15 (PCDH15), myosin 14 (MYH14) and heart shock protein (HSP70) which have been identified in more than one population may be associated with the susceptibility to NIHL...
January 5, 2018: BMC Medical Genetics
Haoran Guo, Enmin Ding, Ying Bai, Hengdong Zhang, Huanxi Shen, Jun Wang, Xianping Song, Wenyan Cai, Jiadi Guo, Baoli Zhu
Noise induced hearing loss (NIHL), a multifactorial disease involving both genetic and environmental factors, is one of the most important occupational health hazards. Nonetheless, the influence of FOXO3 variants on NIHL risk have not been illuminated. This research was conducted to explore the effects of FOXO3 polymorphisms on individual susceptibility to NIHL. A total of 2689 industrial workers from one textile factory of east China were recruited to participate in the current research. Venous blood was collected, questionnaire and pure-tone audiometry (PTA) was conducted by specialist physicians...
2017: PloS One
Stephanie K Sayler, Peter M Rabinowitz, Linda F Cantley, Deron Galusha, Richard L Neitzel
OBJECTIVE: This study characterised overall and specific costs associated with hearing conservation programmes (HCPs) at US metal manufacturing sites, and examined the association between these costs and several noise-induced hearing loss (NIHL) outcomes. DESIGN: We interviewed personnel and reviewed records at participating facilities. We also measured noise for comparison to the ten-year average of measurements made by each facility. NIHL outcomes assessed included rates of standard threshold shifts (STS) and high-frequency hearing loss, as well as prevalence of hearing impairment, for each participating facility...
February 2018: International Journal of Audiology
Song Lei, Liu Huang, Yaqian Liu, Liangwen Xu, Dahui Wang, Lei Yang
BACKGROUND: Recent studies have evaluated the associations between polymorphisms of the heat-shock protein 70 (HSP70) encoding genes and noise-induced hearing loss (NIHL). However, the conclusions of these studies are conflicting. The objective of this meta-analysis was to clarify the association between all known polymorphisms of HSP70 genetic loci and susceptibility to NIHL, based on existing reports. METHODS: We conducted a meta-analysis of the association between Hsp70 polymorphisms (rs1043618, rs1061581, rs2075800, rs2227956, and rs2763979) and NIHL risk in both Chinese and Caucasian males...
2017: PloS One
Jennifer B Tufts, Erika Skoe
OBJECTIVE: To examine the contribution of all daily activities, including non-music activities, to the overall noise exposure of college student musicians, and to compare their "noise lives" with those of non-musician college students. DESIGN: Continuous week-long dosimetry measurements were collected on student musicians and non-musicians. During the measurement period, participants recorded their daily activities in journals. STUDY SAMPLE: 22 musicians and 40 non-musicians, all students (aged 18-24 years) at the University of Connecticut...
February 2018: International Journal of Audiology
Shimin Zong, Xue Zeng, Tianyi Liu, Fangmin Wan, Pan Luo, Hongjun Xiao
BACKGROUND: Several case-control studies reported the relationship between single nucleotide polymorphisms (SNPs) in HSP70 genes and noise-induced hearing loss (NIHL). However, their conclusions are conflicting. This meta-analysis aims to identify the association of HSP70 variants and NIHL susceptibility. METHOD: A systematical literature search was performed in PubMed, Web of Science, EMBASE, and Wanfang Chinese database. The pooled odds radio (OR), 95% confidence interval (CI) and p value were calculated in fixed- or random-effects model according to the I2 value in the heterogeneity test...
2017: PloS One
S Das, M Mulheran, M Brewster, A R Banerjee
OBJECTIVES: The surveillance of noise-induced hearing loss (NIHL) according to the Health and Safety Executive (HSE) differs from the medico-legal criteria used to assess NIHL. Our study compares the two systems and proposes a novel method of simplifying the medico-legal criteria and applying it to ascertain noise-induced hearing loss. DESIGN: The anonymised audiograms of a group of 87 industrial workers from a single site were analysed with both methods. RESULTS: The comparison showed approximately one-third of the workers assessed in this study had their noise-induced hearing loss underestimated by the HSE criteria...
November 9, 2017: Clinical Otolaryngology
Wiesław Sułkowski, Kalina Owczarek, Jurek Olszewski
Hearing impairment caused by noise, traditionally called - depending on the duration of exposure - acute or chronic acoustic trauma, includes, in addition to presbyacusis, the most common adult population of hearing impaired. In Poland - according to the report of the Central Statistical Office (GUS, 2011), the number of workers employed in NDN exceeded the noise level (85 dB) is about 200 thousand, the highest in the mining, metal and metal products production, textiles and wood production. According to the Regulation of the Council of Ministers of on June 30, 2009, on the list of occupational diseases (Journal of Laws No...
August 31, 2017: Otolaryngologia Polska
Phayong Thepaksorn, Akio Koizumi, Kouji Harada, Wattasit Siriwong, Richard L Neitzel
The aim of this study was to investigate occupational noise exposure and hearing defects among sawmill workers in the South of Thailand. Seven hundred sawmill workers participated, of which 335 (47.9%) were male. The mean age of the sawmill workers was 33.5 years old (SD = 10.2), and more than 60% were <35 years old. 75.1% of the workers had less than 5 years of work experience. Only about one in four workers (25%) had been trained on use of personal protective equipment (PPE), and half of participants never or rarely wore PPEs while working...
October 23, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
Megan Gilliver, Jenny Nguyen, Elizabeth F Beach, Caitlin Barr
Personal listening devices (PLDs) have the potential to increase the risk of noise-induced hearing loss (NIHL) for users. The present study aimed to investigate the nature and extent of the risk posed, by describing the user profile of a PLD population, identifying listening habits of that population, and examining whether PLD risk status is associated with hearing damage. A sample of 4,185 Australian PLD users completed an online survey about listening behaviors and hearing health. Listeners were characterized as low, high, or very high-risk based on daily noise dose estimates calculated from self-reported listening volume and durations...
November 2017: Seminars in Hearing
Deanna K Meinke, Donald S Finan, Gregory A Flamme, William J Murphy, Michael Stewart, James E Lankford, Stephen Tasko
In the United States and other parts of the world, recreational firearm shooting is a popular sport that puts the hearing of the shooter at risk. Peak sound pressure levels (SPLs) from firearms range from ∼140 to 175 dB. The majority of recreational firearms (excluding small-caliber 0.17 and 0.22 rifles and air rifles) generate between 150 and 165 dB peak SPLs. High-intensity impulse sounds will permanently damage delicate cochlear structures, and thus individuals who shoot firearms are at a higher risk of bilateral, high-frequency, noise-induced hearing loss (NIHL) than peer groups who do not shoot...
November 2017: Seminars in Hearing
Parvaneh Nasezadeh, Farshad Shahi, Mohammadjavad Fridoni, Enayatollah Seydi, Morteza Izadi, Ahmad Salimi
Mitochondrial damage and oxidative stress are known to contribute to the pathogenesis of noise-induced hearing loss (NIHL). In this study, we examined the protective effect of O2/O3 mixture (ozone/oxygen) therapy against mitochondrial induced damage and oxidative stress by noise exposure in rat brain and cochlear. For this purpose, rats were divided into four groups: 1 - control group; 2 - noise-exposed group (100 dB); 3 - noise + O2/O3, and 4 - O2/O3 (30 µg/ml). After 14 d, animals were anesthetised...
October 2017: Free Radical Research
Jason Powell, Kris Chesky
Student musicians are at risk for noise-induced hearing loss (NIHL) as they develop skills and perform during instructional activities. Studies using longitudinal dosimeter data show that pedagogical procedures and instructor behaviors are highly predictive of NIHL risk, thus implying the need for innovative approaches to increase instructor competency in managing instructional activities without interfering with artistic and academic freedom. Ambient information systems, an emerging trend in human-computer interaction that infuses psychological behavioral theories into technologies, can help construct informative risk-regulating systems...
September 2017: Medical Problems of Performing Artists
Yu Mizushima, Chisato Fujimoto, Akinori Kashio, Kenji Kondo, Tatsuya Yamasoba
It has been suggested that macrophages or inflammatory monocytes participate in the pathology of noise-induced hearing loss (NIHL), but it is unclear how extensively these cells contribute to the development of temporary and/or permanent NIHL. To address this question, we used clodronate liposomes to deplete macrophages and monocytes. After clodronate liposome injection, mice were exposed to 4-kHz octave band noise at 121 dB for 4 h. Compared to vehicle-injected controls, clodronate-treated mice exhibited significantly reduced permanent threshold shifts at 4 and 8 kHz and significantly smaller outer hair cell losses in the lower-apical cochlear turn...
November 18, 2017: Biochemical and Biophysical Research Communications
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