keyword
MENU ▼
Read by QxMD icon Read
search

Ototoxic

keyword
https://www.readbyqxmd.com/read/29676584/current-practice-of-ototoxicity-management-across-the-united-kingdom-uk
#1
Devina Maru, Ghada-Al Malky
OBJECTIVE: Effective management of patients diagnosed with ototoxicity is needed to reduce hearing and balance damage which affects communication and life quality. Despite widespread recommendations to monitor and manage ototoxicity in an early and effective manner, there is limited evidence to support the actual implementation of these recommendations for affected patient groups in healthcare services across the UK with limited publications available. In this study, an online questionnaire analysed the current practice of ototoxicity management and patient pathways across the UK once the diagnosis of ototoxicity was confirmed, targeting Audiologists, ENTs/AVPs and GPs...
April 20, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29673779/protective-effect-of-gallic-acid-against-cisplatin-induced-ototoxicity-in-rats
#2
Korhan Kilic, Muhammed Sedat Sakat, Fazile Nur Ekinci Akdemir, Serkan Yildirim, Yavuz Selim Saglam, Seda Askin
INTRODUCTION: Cisplatin is an antineoplastic agent widely used in the treatment of a variety of cancers. Ototoxicity is one of the main side-effects restricting the use of cisplatin. OBJECTIVE: The purpose of this study was to investigate the protective efficacy of gallic acid, in biochemical, functional and histopathological terms, against ototoxicity induced by cisplatin. METHODS: Twenty-eight female Sprague Dawley rats were included. Rats were randomly assigned into four groups of seven animals each...
April 7, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29673769/successful-treatment-of-a-recurrent-aspergillus-niger-otomycosis-with-local-application-of-voriconazole
#3
M Chappe, S Vrignaud, L de Gentile, G Legrand, F Lagarce, Y Le Govic
Fungal otitis (otomycosis) is a common infection encountered by otolaryngologists. Nevertheless, its management can be challenging because of its high recurrence rate and of the limited therapeutic options. A 45-year-old woman suffered from recurrent otomycosis. The ineffectiveness of successive antibiotic cures and repeated topical treatments with nystatin and then with econazole cream led to perform microbiological analyses. Culture of ear swab grew Aspergillus niger. The use of a 1% voriconazole sterile solution previously validated for treatment of eye infections was considered after ensuring the absence of known ototoxic effects of the antifungal and of the excipients...
April 16, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29670654/toxicities-associated-with-cisplatin-based-chemotherapy-and-radiotherapy-in-long-term-testicular-cancer-survivors
#4
REVIEW
Chunkit Fung, Paul Dinh, Shirin Ardeshir-Rouhani-Fard, Kerry Schaffer, Sophie D Fossa, Lois B Travis
Testicular cancer has become the paradigm of adult-onset cancer survivorship, due to the young age at diagnosis and 10-year relative survival of 95%. This clinical review presents the current status of various treatment-related complications experienced by long-term testicular cancer survivors (TCS) free of disease for 5 or more years after primary treatment. Cardiovascular disease and second malignant neoplasms represent the most common potentially life-threatening late effects. Other long-term adverse outcomes include neuro- and ototoxicity, pulmonary complications, nephrotoxicity, hypogonadism, infertility, and avascular necrosis...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29670475/investigation-the-relationship-between-skin-involvement-severity-and-hearing-loss-severity-in-vitiligo-patients
#5
Ahmad Yeganeh Moghaddam, Mansour Sayyah, Elham Alian Fini, Rezvan Talaee
Introduction: Vitiligo is a common acquired depigmented systemic disorder influencing the entire pigmentary system including Cochlear melanocytes and vestibular system in the inner ear. Vitiligo can leads to social negative impact and poorer quality of life among these patients. This study was conducted to investigate the relationship between skin involvement severity and hearing loss severity among vitiligo patients. Methods: This cross-sectional study was performed on 98 patients with vitiligo referred to the dermatology clinic of Shahid Beheshti Hospital of Kashan during 2012-2014...
March 2018: Materia Socio-medica
https://www.readbyqxmd.com/read/29665656/forskolin-protects-against-cisplatin-induced-ototoxicity-by-inhibiting-apoptosis-and-ros-production
#6
Xiangrui Guo, Xiaohui Bai, Li Li, Jianfeng Li, Haibo Wang
Cisplatin is widely used in the treatment of various types of cancer. However, it could cause severe side effects such as ototoxicity, which greatly limit the clinical application of cisplatin. Forskolin (FSK) is a diterpene derived from the plant Coleus forskohlii, and has been proven an effective drug for cardiovascular disease, diabetes, and asthma because of its anti-oxidant and anti-inflammatory action. Here, we investigated the effects of FSK in cisplatin-induced ototoxicity, and we found that FSK could significantly protect against cisplatin-induced ototoxicity in both cell line and isolated mouse cochlear...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29662441/characterization-of-hair-cell-like-cells-converted-from-supporting-cells-after-notch-inhibition-in-cultures-of-the-organ-of-corti-from-neonatal-gerbils
#7
Yi Li, Shuping Jia, Huizhan Liu, Tomoko Tateya, Weiwei Guo, Shiming Yang, Kirk W Beisel, David Z Z He
The senses of hearing and balance depend upon hair cells, the sensory receptors of the inner ear. Hair cells transduce mechanical stimuli into electrical activity. Loss of hair cells as a result of aging or exposure to noise and ototoxic drugs is the major cause of noncongenital hearing and balance deficits. In the ear of non-mammals, lost hair cells can spontaneously be replaced by production of new hair cells from conversion of supporting cells. Although supporting cells in adult mammals have lost that capability, neonatal supporting cells are able to convert to hair cells after inhibition of Notch signaling...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29661870/amikacin-inhalation-as-salvage-therapy-for-refractory-nontuberculous-mycobacterial-lung-disease
#8
Byung Woo Jhun, Bumhee Yang, Seong Mi Moon, Hyun Lee, Hye Yun Park, Kyeongman Jeon, O Jung Kwon, Jungmin Ahn, Il Joon Moon, Sung Jae Shin, Charles L Daley, Won-Jung Koh
Although guidelines recommend amikacin (AMK) inhalation therapy for difficult-to-treat nontuberculous mycobacterial lung disease (NTM-LD), data are limited regarding the safety and clinical efficacy of this salvage therapy. We retrospectively evaluated treatment outcomes of 77 patients with refractory NTM-LD caused by Mycobacterium abscessus complex (MABC) or M. avium complex (MAC) who initiated AMK inhalation therapy between February 2015 and June 2016. MABC was the most common etiology (n = 48, 62%), followed by MAC (n = 20, 26%) and mixed infections (n = 9, 12%)...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29615272/mitochondrial-mutations-associated-with-hearing-and-balance-disorders
#9
REVIEW
Iman Ibrahim, Mev Dominguez-Valentin, Bernard Segal, Anthony Zeitouni, Sabrina Daniela da Silva
Hearing and balance disorders are related to the inner ear and are among the major cause of falls in older adults. Hearing loss that commonly occurs with aging (aka presbyacusis) can result from noise exposure, smoking, ototoxic drugs and genetic factors such as mutations in nuclear and mitochondrial genes. Mutations in mitochondrial DNA (mtDNA) have been reported to play an important role in cell function by providing energy, as well as, cell death (apoptosis). This study aims to systematically review mitochondrial mutations associated with presbyacusis and suggests preventive measurements to improve the quality of life in older adults...
March 10, 2018: Mutation Research
https://www.readbyqxmd.com/read/29609517/pd-1-inhibition-minimally-affects-cisplatin-induced-toxicities-in-a-murine-model
#10
Katie Spielbauer, Lisa Cunningham, Nicole Schmitt
Immune checkpoint inhibition used in combination with standard cisplatin-based chemotherapy regimens is currently under evaluation in clinical trials for head and neck squamous cell carcinoma (HNSCC). The impact of anti-PD-1 therapy on cisplatin-induced ototoxicity and nephrotoxicity has not been established. Here we use a murine model of cisplatin-induced hearing loss to investigate the impact of anti-PD-1 immunotherapy on auditory brainstem responses (ABRs), distortion product otoacoustic emissions (DPOAEs), serum creatinine, and hair cell and renal histology...
March 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29608150/trans-tympanic-drug-delivery-for-the-treatment-of-ototoxicity
#11
Kelly Sheehan, Sandeep Sheth, Debashree Mukherjea, Leonard P Rybak, Vickram Ramkumar
The systemic administration of protective agents to treat drug-induced ototoxicity is limited by the possibility that these protective agents could interfere with the chemotherapeutic efficacy of the primary drugs. This is especially true for the drug cisplatin, whose anticancer actions are attenuated by antioxidants which provide adequate protection against hearing loss. Other current or potential otoprotective agents could pose a similar problem, if administered systemically. The application of various biologicals or protective agents directly to the cochlea would allow for high levels of these agents locally with limited systemic side effects...
March 16, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29595337/mitochondria-homing-peptide-functionalized-nanoparticles-performing-dual-extracellular-intracellular-roles-to-inhibit-aminoglycosides-induced-ototoxicity
#12
Shuang Zhou, Yanhui Sun, Xiao Kuang, Shanshan Hou, Zhenjie Wang, Zhe Qian, Hongzhuo Liu
One of the major challenges in the treatment of hearing loss is the low efficacy of therapeutic candidates. To achieve the optimum drug efficacy, we designed a novel peptide (D-Arg-Dmt-Arg-Phe-NH2 )-mediated mitochondrial targeted delivery nanosystem for a promising candidate, geranylgeranylacetone (GGA). The zebrafish lateral line system, a robust model for mammalian hair cells, was used to identify the efficacy against gentamicin, a well-known ototoxic agent. The nanosystem facilitated lysosomal escape and mitochondrial accumulation, and thus conferred superior protective efficacy against a wide range of gentamicin compared with unmodified NPs and free drugs...
March 29, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29575954/ototoxicity-the-radical-drum-beat-and-rhythm-of-cochlear-hair-cell-life-and-death
#13
David V Gauvin, Joshua Yoder, Zachary J Zimmermann, Rachel Tapp
The function and structure of the auditory information processing system establishes a unique sensory environment for the "perfect storm." The battle between life and death pits the cascade of an apoptotic storm, programmed cell death cascades, against simple cell death (necrosis) pathways. Live or die, the free radical biology of oxygen and hydroxylation, and the destruction of transition metal migration through the mechanical gate sensory processes of the hair cell lead to direct access to the cytoplasm, cytoplasmic reticulum, and mitochondria of the inner workings of the hair cells...
January 1, 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29571735/regional-up-regulation-of-nox2-contributes-to-the-differential-vulnerability-of-outer-hair-cells-to-neomycin
#14
Meihao Qi, Yang Qiu, Xueying Zhou, Keyong Tian, Ke Zhou, Fei Sun, Bo Yue, Fuquan Chen, Dingjun Zha, Jianhua Qiu
In hearing loss induced by aminoglycoside antibiotics, the outer hair cells (OHCs) in the basal turn are always more susceptible than OHCs in the apical turn, while the underlying mechanisms remain unknown. In this study, we reported that NAPDH oxidase 2 (NOX2) played an important role in the OHCs damage preferentially in the basal turn. Normally, NOX2 was evenly expressed in OHCs among different turns, at a relatively low level. However, after neomycin treatment, NOX2 was dominantly induced in OHCs in the basal turn...
March 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29559948/amiodarone-a-newly-discovered-association-with-bilateral-vestibulopathy
#15
REVIEW
Robert Gürkov
Background: Bilateral vestibulopathy (BVP) is a debilitating disorder characterized by the hypofunction of both vestibular end organs or nerves. The most frequent identifiable causes of BVP are ototoxic drug effects, infectious and autoimmune disorders. However, the majority of cases remain idiopathic. Very recently, the first discovery of a clinical case of Amiodarone-associated BVP has been reported. Methods: An overview of the literature concerning the relation between amiodarone toxicity and BVP is presented and discussed...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29549688/identification-of-risk-factors-for-hearing-impairment-in-newborns-a-hospital-based-study
#16
Nermin Hrnčić
Aim To identify risk factors for hearing impairment presented in neonates born in Cantonal Hospital Zenica (CHZ) and to estimate their influence on outcome of hearing tests in Newborn Hearing Screening (NHS). Methods Retrospective-prospective study was done at the Department of Gynaecology and Maternity. The NHS was performed with transitory evoked otoacoustic emissions (TEOAE) during a six-month period using "Titan" device (Interacoustics, Denmark). The questionnaire was written for the purpose of getting more structured basic information about every newborn and to identify risk factors for hearing impairment...
February 1, 2018: Medicinski Glasnik
https://www.readbyqxmd.com/read/29545765/clinical-characteristics-and-etiology-of-bilateral-vestibular-loss-in-a-cohort-from-central-illinois
#17
Jorge C Kattah
Background: Previous series of bilateral vestibular loss (BVL) identified numerous etiologies, but surprisingly, a cause in a significant number of cases remains unknown. In an effort to understand possible etiology and management strategies, a global effort is currently in progress. Here, I contribute my 10-year experience with both acute and chronic BVL during the 2007-2017 decade. Methods: This is a retrospective review of the charts and EMR of patients diagnosed with BVL in the last 10 years...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29530589/cisplatin-induced-gastrointestinal-toxicity-an-update-on-possible-mechanisms-and-on-available-gastroprotective-strategies
#18
REVIEW
Faaiza Shahid, Zeba Farooqui, Farah Khan
Cisplatin (cis-diamminedichloroplatinum [II], CP) is most widely prescribed in chemotherapy and efficaciously treats diverse human cancers, with remission rates >90% in testicular cancers. However, clinical use of CP is associated with numerous untoward side effects, in particular, at the gastrointestinal level that reduces the therapeutic efficacy of CP and often results in withdrawal of its clinical usage in long term cancer chemotherapy. Substantial strides have been made to identify effective protective strategies against CP-induced nephrotoxicity, hepatotoxicity and ototoxicity...
March 9, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29519695/otoacoustic-emissions-in-children-treated-with-gentamicin-in-a-secondary-hospital
#19
Jose Miguel Sequi Canet, Carlos Miguel Angelats Romero, Jose Miguel Sequi Sabater, Ana Miralles Torres, Miguel Boronat Garcia, Marta Gomez Delgado
INTRODUCTION: The National Commission for the Early Detection of Hearing Loss (CODEPEH) recommends the re-evaluation of hearing in children who have suffered any potentially harmful event, such as the prescription of ototoxic antibiotics such as gentamicin. The evoked otoacoustic emissions (EOAE) are a good method for assessing the integrity of cochlear functionality. MATERIAL AND METHOD: A prospective study is presented, including 92 children who were treated with intravenous gentamicin for septic risk/sepsis or urinary tract infection...
March 5, 2018: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/29516565/the-three-dimensional-structure-of-neob-an-aminotransferase-involved-in-the-biosynthesis-of-neomycin
#20
Garrett T Dow, James B Thoden, Hazel M Holden
The aminoglycoside antibiotics, discovered as natural products in the 1940s, demonstrate a broad anti-microbial spectrum. Due to their nephrotoxic and ototoxic side effects, however, their widespread clinical usage has typically been limited to the treatment of serious infections. Neomycin B, first isolated from strains of Streptomyces in 1948, is one such drug that was approved for human use by the U. S. Food and Drug Administration in 1964. Only within the last 11 years has the biochemical pathway for its production been elaborated, however...
March 8, 2018: Protein Science: a Publication of the Protein Society
keyword
keyword
50913
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"