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Domenico Prisco
No abstract text is available yet for this article.
September 21, 2018: Internal and Emergency Medicine
Mehdi Najafzadeh, Sebastian Schneeweiss, Niteesh K Choudhry, Jerry Avorn, Joshua J Gagne
OBJECTIVES: Preference weights derived from general population samples are often used for therapeutic decision making. In contrast, patients with cardiovascular disease may have different preferences concerning the benefits and risks of anticoagulant therapy. Using a discrete choice experiment, we compared preferences for anticoagulant treatment outcomes between the general population and patients with cardiovascular disease. METHODS: A sample of the general US population and a sample of patients with cardiovascular disease were selected from online panels...
September 21, 2018: Patient
Warren Clements
Risks of IVC filter insertion are numerous but include IVC stenosis or thrombosis and may result in caval occlusion. Acute IVC occlusion is almost always symptomatic, and treatment can be aggressive such as catheter-directed thrombolysis or conservative such as anticoagulation. The more challenging cohort of patients is those where there has been chronic complete occlusion of the IVC without symptoms, sometimes only identified at the time of routine filter retrieval. We explore the available evidence and discuss different management approaches in this circumstance ranging from aggressive to conservative...
September 21, 2018: Cardiovascular and Interventional Radiology
Michelle Sholzberg, Yan Xu
No abstract text is available yet for this article.
September 14, 2018: JAMA: the Journal of the American Medical Association
Shan Li, Junhui Li, Guizhu Mao, Yaqin Hu, Xingqian Ye, Ding Tian, Robert J Linhardt, Shiguo Chen
Fucosylated chondroitin sulfate (fCS) and its depolymerized derivative (DfCS), prepared from sea cucumbers, are well-known for their anticoagulant activity. However, their other functional activities are poorly understood. Recently, we obtained fCS oligosaccharides from Isostichopus Badionotus by a modified controllable Fenton-system, named as DfCS-Ib. The functional activities of these oligosaccharides are still unclear. The present study investigated anti-hyperlipidemic activity of DfCS-Ib using a high-fat diet (HFD)-fed mice model...
December 1, 2018: Carbohydrate Polymers
Mélanie Abonnenc, Jean-Daniel Tissot, Michel Prudent
Blood products are issued from blood collection. Collected blood is immediately mixed with anticoagulant solutions that immediately induce chemical and/or biochemical modifications. Collected blood is then transformed into different blood products according to various steps of fabrication. All these steps induce either reversible or irreversible "preparation-related" lesions that combine with "storage-related" lesions. This short paper aims to provide an overview of the alterations that are induced by the "non-physiological" processes used to prepare blood products that are used in clinical practice...
August 31, 2018: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
Basel Ramlawi, Kareem Bedeir, James R Edgerton
The left atrial appendage (LAA) is a major site of clot formation in atrial fibrillation. Stand-alone thoracoscopic LAA complete closure can decrease stroke risk and may be an alternative to life-long oral anticoagulation.1 We describe our technique for totally thoracoscopic LAA exclusion with an epicardial clip device. This approach provides a safe and likely more effective alternative to LAA management than other endocardial devices.
September 18, 2018: Annals of Thoracic Surgery
Joshua D Brown, Amie Goodin, Gregory Yh Lip
In patients with venous thromboembolism (VTE), the goal of anticoagulation is to treat the current VTE and to prevent recurrent VTE. However, anticoagulation also imposes an increased risk for bleeding events and this risk must be assessed to determine appropriateness of a given treatment plan for each patient. The American College of Chest Physicians (ACCP) guidelines for VTE management presented a set of 18 risk factors and scoring system to distinguish patients with a low, moderate, or high risk of bleeding...
September 21, 2018: Journal of Thrombosis and Haemostasis: JTH
Gualtiero Palareti, Emilia Antonucci, Walter Ageno, Daniela Mastroiacovo, Daniela Poli, Alberto Tosetto
We would like to thank Dr Brown and colleagues for the attention they gave to our study on ACCP bleeding score. We have read with interest their communication and share most of their comments. We agree that bleeding risk scores may be used, sometimes inappropriately, to deny anticoagulation for patients perceived at high risk of bleeding. In our opinion, bleeding scores should mainly be used to drive the decision on the duration of anticoagulation beyond the first three months, a treatment period required for all patients with acute venous thromboembolism (VTE), regardless of the individual risk of bleeding...
September 21, 2018: Journal of Thrombosis and Haemostasis: JTH
Neil A Zakai, Rob F Walker, Richard F MacLehose, Terrence J Adam, Alvaro Alonso, Pamela L Lutsey
BACKGROUND: Direct acting oral anticoagulants (DOAC) are associated with less bleeding than traditional venous thromboembolism (VTE) treatments in the general population but are little studied in cancer-associated VTE (CA-VTE). OBJECTIVE: To determine whether different anticoagulation strategies for CA-VTE have different hospitalized bleeding rates. PATIENTS/METHODS: We conducted a retrospective study of patients with CA-VTE diagnosed between 2011-2015 in a large administrative database...
September 21, 2018: Journal of Thrombosis and Haemostasis: JTH
Zichao Liu, Yanjie Wang, Xiangrong Tong, Yuan Su, Lijiang Yang, Debin Wang, Yuqi Zhao
Leeches (family Hirudinidae) are classic model invertebrates used in diverse clinical treatments, such as reconstructive microsurgery, hypertension, and gangrene treatment. The blood-feeding habit is essential for these therapies, yet the molecular mechanisms underlying the process are poorly understood. In the present study, the transcriptome of Poecilobdella javanica from five time points (days 0, 1, 10, 20, and 30 separately) of blood feeding was sequenced with short paired-end reads. After stringent quality control, ∼380 million high-quality reads were assembled using SOAPdenovo-Trans with optimal parameters into a non-redundant set of 48 784 transcripts (≥100 base pairs), representing about 38 Mb of unique transcriptome sequence...
September 21, 2018: Molecular omics
Ryan W Haines, Christopher J Kirwan, John R Prowle
PURPOSE OF REVIEW: Continuous renal replacement therapy (CRRT) is now the mainstay of renal organ support in the critically ill. As our understanding of CRRT delivery and its impact on patient outcomes improves there is a focus on researching the potential benefits of tailored, patient-specific treatments to meet dynamic needs. RECENT FINDINGS: The most up-to-date studies investigating aspects of CRRT prescription that can be individualized: CRRT dose, timing, fluid management, membrane selection, anticoagulation and vascular access are reviewed...
September 18, 2018: Current Opinion in Critical Care
Rebecca Bei Jia Cui, Kheng-Seong Ng, Christopher J Young
BACKGROUND: Postoperative hemorrhage and thromboembolism are recognized complications following colorectal and abdominal wall surgery, but accurate documentation of their incidence, trends, and outcomes is scant. This is relevant given the increasing number of surgical patients with cardiovascular comorbidity on anticoagulant/antiplatelet therapy. OBJECTIVE: This study aims to characterize trends in the use of anticoagulant/antiplatelet therapy among patients undergoing major colorectal and abdominal wall surgery within the past decade, and to assess rates of, outcomes following, and risk factors for hemorrhagic and thromboembolic complications...
September 19, 2018: Diseases of the Colon and Rectum
Chérifi Fatah, Saoud Samah, Laraba-Djebari Fatima
This study aimed to elucidate anticoagulant/antiplatelet mechanisms of two previously purified PLA2 s from Cerastes cerastes venom, here, termed Cc1 -PLA2 and Cc2 -PLA2 . Both PLA2 s present close molecular weights of 13,534 and 13,430 Da and Isoectric pH (pI) 7.38 and 7.86 respectively, for Cc1 -PLA2 and Cc2 -PLA2 . These Ca2+ -dependent enzymes showed a high catalytic activity upon phospholipids, inducing indirect hemolysis, since they conserve the catalytic domain of PLA2 s 26 CYCGWGGKG34 . They exhibited dual inhibition of platelet aggregation by targeting P2 Y12 and TPα receptors preventing Adenosine diphosphate/arachidonate binding and blood clotting...
September 21, 2018: Journal of Biochemical and Molecular Toxicology
Ming-Chan Wu, Kuan-Ting Liu, I-Jeng Yeh, Yen-Hung Wu
There were few case reports discuss about iatrogenic chest wall hematoma. Although it is rare life threatening, it still can result in significant morbidity. A 68-year-old woman with histories of end-stage renal disease under regular hemodialysis and congestive heart failure was sent to our emergency department because of progression of ecchymosis over the anterior chest wall a few hours after hemodialysis. The right subclavian hemodialysis catheter was inserted for hemodialysis on the same day. She did not have a history of bleeding disorders and was not taking any antiplatelet or anticoagulant agents...
October 2018: American Journal of Emergency Medicine
Marta Cuadros Martínez, Consuelo Froilán Torres, Nerea Gonzalo Bada
Dabigatran is an oral anticoagulant prescribed as an alternative to warfarin which has been associated with exfoliative esophagitis and esophageal ulcer. We report a new case of dabigatran-induced exfoliative esophagitis where the mucosal injury improved after prescribing proton-pump inhibitors and ingesting medication with sufficient water.
September 21, 2018: Revista Española de Enfermedades Digestivas
Avi Sabbag, Xiaoxi Yao, Konstantinos C Siontis, Peter A Noseworthy
The burden of atrial fibrillation (AF) is projected to increase substantially over the next decade in parallel with the aging of the population. The increasing age, level of comorbidity, and polypharmacy will complicate the treatment of older adults with AF. For instance, advanced age and chronic kidney disease have been shown to increase the risk of both thromboembolism and bleeding in patients with AF. Frailty, recurrent falls and polypharmacy, while very common among elderly patients with AF, are often overlooked in the clinical decision making despite their significant interaction with oral anticoagulant (OAC) and profound impact on the patient's clinical outcomes...
October 2018: Korean Circulation Journal
Dan Zhang, Jin Wang, Qiaowei Zhang, Feifang He, Xingyue Hu
OBJECTIVE: Spontaneous intracranial hypotension is a risk factor for cerebral venous thrombosis. The occurrence of cerebral venous thrombosis in patients with spontaneous intracranial hypotension raises difficult practical questions regarding the management of the 2 conditions. We reviewed our experience and the relevant literature to evaluate these related questions. METHODS: We retrospectively studied the medical records and imaging studies of patients with spontaneous intracranial hypotension at a tertiary center from January 2007 through January 2017...
September 20, 2018: Headache
Marco Skardelly, Lisa Mönch, Constantin Roder, Konstantin Hockel, Marcos Soares Tatagiba, Florian H Ebner
BACKGROUND: A growing number of patients on anticoagulation or antiplatelet therapy (APT) are planned for elective surgery. The management of perioperative anticoagulation and APT is challenging because it must balance the risk of thromboembolism and bleeding, and specific recommendations for the management of bridging in neurosurgical patients are lacking. We surveyed German neurosurgical centers about their management of perioperative bridging of anticoagulation and APT to provide an overview of the current bridging policy...
September 20, 2018: Acta Neurochirurgica
Georgios Tziatzios, Paraskevas Gkolfakis, Ioannis S Papanikolaou, Konstantinos Triantafyllou
INTRODUCTION: The impact of antithrombotic treatment on the findings of small-bowel capsule endoscopy for patients with obscure gastrointestinal bleeding remains contentious. We aimed to determine the effect of these agents on small-bowel video capsule endoscopy positive findings. METHODS: MEDLINE, Cochrane Library, and Google Scholar were searched for studies reporting on patients receiving concurrent antithrombotic treatment, while undergoing capsule endoscopy for obscure gastrointestinal bleeding (OGIB)...
September 20, 2018: Digestive Diseases and Sciences
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