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So Young Park, Chung Hyeon Kim, Ji Yoon Lee, Jang Su Jeon, Min Ju Kim, Song Hee Chae, Hyoung Chin Kim, Soo Jin Oh, Sang Kyum Kim
In this study, the hepatic expression of cytochrome P450 (CYP) enzymes, including CYP1A1/2, 2B1, 2C11, 2E1, 3A1/2, and 4A, was investigated in 5-week-old (insulinresistant state) and 11-week-old (diabetic) Zucker diabetic fatty (ZDF) rats. Serum glucose and glycated hemoglobin levels were increased in 11-week-old ZDF rats, but not in 5-weekold ZDF rats. Hyperinsulinemia was observed in both age groups. The microsomal protein, total CYP, CYP reductase, CYP1A1/2, and CYP3A1 levels did not differ between 5- and 11-week-old ZDF rats and their respective control rats, while CYP4A was up-regulated in both groups...
October 2016: Food and Chemical Toxicology
T Mohammad, N Farzad, G Mohammad Tagie, K Ranjbar
AIM: Recent studies, shows the effective role of adipose tissue as an active endocrine organ. Leptin level increases in obese bodies while adiponectin as an antirisk factor reduction that contributes to decrease insulin resistance and anthropometric profiles. Hence, expected to the negative effects of weight loss on wrestlers' physiological function; leptin and adiponectin behaviors and insulin resistance in young wrestlers during their rapid weight loss program were examined. METHODS: Fifteen young (23±1 yr) freestyle wrestlers with (weight 67...
July 2015: Journal of Sports Medicine and Physical Fitness
V V Ivanov, E V Shakhristova, E A Stepovaya, O L Nosareva, T S Fedorova, V V Novitsky
Analysis of modern literature data as well as the results of personal research on development of oxidative stress in adipose tissue in diabetes is presented. Mechanisms of modulation of spontaneous and induced lipolysis in adipocytes in conditions of oxidative stress are discussed. Participation of adipose tissue in forming insulin resistance in types 1 and 2 diabetes is considered.
October 2014: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
Khansa Chaabouni, Amina Lahyani, Mouna Turki, Mariem Messedi, Doulira Louati, Kamel Jamoussi, Fatma Ayedi
Polycystic ovary syndrome (PCOS) and weight excess exhibited metabolic abnormalities and elevated cardiovascular risk. Our objective was to assess metabolic and inflammatory profiles in women with PCOS associated to weight excess; 85 women were enrolled. Four groups were then identified with and without PCOS and/or weight excess. Hyperlipidemia was significantly more observed in the two groups with weight excess. In whom insulinresistance and high sensitive C reactive protein were also elevated. Abnormalities observed when PCOS and weight excess are associated would mimic these observed in isolated weight excess with some particularities...
July 2014: Annales de Biologie Clinique
B Gaborit, I Abdesselam, F Kober, A Jacquier, O Ronsin, O Emungania, N Lesavre, M-C Alessi, J C Martin, M Bernard, A Dutour
OBJECTIVES: Recent literature suggests that ectopic fat deposition in the pancreas may contribute to endocrine and exocrine organ dysfunction, such as type 2 diabetes (T2D), pancreatitis or pancreatic cancer. The aim of this study was to determine factors associated with pancreatic triglyceride content (PTGC), and to investigate the impact of bariatric surgery on ectopic fat pads, pancreatic fat (PTGC) and hepatic fat (HTGC). SUBJECTS: In all, 45 subjects (13 lean, 13 obese nondiabetics and 19 T2D, matched for age and gender) underwent 1H-magnetic resonance spectroscopy, computed tomography of the visceral abdominal fat, metabolic and lipidomic analysis, including insulin-resistance homeostasis model assessment (HOMA-IR), insulin-secretion homeostasis model assessment (HOMA-B) and plasma fatty-acid composition...
March 2015: International Journal of Obesity: Journal of the International Association for the Study of Obesity
(no author information available yet)
The analysis of new data concerning the development of pathology due to the community of evolutionary new pathological factors was done. Author provides the comparison of well-known and new definition for "metabolic syndrome" and diagnostic criteria of this pathology. The conception for permanent activation of nuclear factor kbeta as possible typic pathological process was discussed. Suppose that NF-kbeta is the possible key molecule in the initiation and formation of "vicious circle"--insulinresistance--inflammation--atherosclerosis...
July 2013: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
Ewa Ziółkowska, Małgorzata Zarzycka, Tomasz Wiśniewski, Agnieszka Zyromska
Prostate cancer is one of most frequent malignant tumours at men. The androgen-deprivation therapy is the part of cancer treatment. It could be used both in the early stage of prostate cancer and in the bone metastates. From this reason the antiandrogen drugs waste systematically grows. Unfortunately androgen-deprivation therapy has numerous side effects such as: the inferior quality of live, sexual disturbances, the fatigue, the anaemia, the bone mineral density loss and the increase of the risk of breaks the bone, the increase of body mass, insulinresistance, hypercholesterolemia, the increase risk of cardiac disorders...
2012: Contemporary Oncology Współczesna Onkologia
Carmen E Pepene
UNLABELLED: HASH(0x39d2fe0) BACKGROUND: Under-carboxylated osteocalcin (ucOC), the precursor substrate of bone biomarker OC is a potent regulator of energy metabolism by promoting insulin production and adiponectin synthesis and decreasing fat stores. The aim of the present study was to point out the potential role of ucOC in the physiopathology of polycystic ovary syndrome (PCOS), a common disorder defined by the constellation of anovulation, insulinresistance, hyperinsulinemia, obesity and androgen excess...
2013: Journal of Ovarian Research
Daniela Maria Hurjui, Otilia Niţă, Lidia Iuliana Graur, Laura Mihalache, Dana Stefana Popescu, Mariana Graur
Non-alcoholic fatty liver disease (NAFLD) covers a spectrum of liver disease from steatosis to non-alcoholic steatohepatitis (NASH) and cirrhosis. Most NAFLD patients are hyperinsulinaemic and more insulin resistant compared with nonsteatotic healthy subjects, and there is a near universal association between NAFLD and insulinresistance (IR) irrespective of obesity. The metabolic syndrome (MS) is highly prevalent in the general adult population (approximatively 22%) and it carries an increased cardiovascular morbidity and mortality...
April 2012: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
Mohammad Javad Hosseinzadeh Atar, Hossein Hajianfar, Ahmad Bahonar
BACKGROUND: Hypertension is a condition normally detected in people with type II diabetes.It eventually leads to cardiovascular diseases in the patient. Visfatin is an adipocytokine which issecreted from adipose tissue and can affect the inflammatory reaction and also serum lipidlevels. Additionally, omega-3 inhibits the accumulation of fat and formation of insulinresistance. The current study tried to investigate the effects of omega-3 on blood pressurecompared to placebo and the relationship between serum visfatin levels and blood pressure...
2012: ARYA Atherosclerosis
Marta Moniz, Tânia Marques, Marta Cabral, Zahara Nizarali, Raquel Coelho, Ana Monteiro, Graciete Bragança, Helena Carreiro
BACKGROUND: Even in pediatric age, obesity is associated to cardiovascular risk factors such as dyslipidemia, high blood pressure and metabolic syndrome, which contribute to increased morbidity and mortality in adulthood. AIMS: characterize the prevalence of cardiovascular risk factors in obese children and adolescents followed in pediatric endocrinology. METHODS: retrospective analysis of cases followed between January 1997 and June 2008, with age between two and eighteen years...
December 2011: Acta Médica Portuguesa
B Francq, S Sohawon, I Perlot, H Sekkat, S O Noordally
Preoperative fasting is a currently adopted measure since Mendelson's report pertaining to aspiration pneumonia as a cause of death following general anesthesia. From a metabolic point of view fasting is detrimental because surgery in itself causes a state of hypercatabolism and hyperglycemia as a result of insulinresistance. Preoperative fasting has become almost obsolete in certain elective surgical procedures. In these cases the use of clear liquids is now well established and this paper focuses on the safe use of clear fluids, postoperative insulinresistance, patient comfort and postoperative outcome as well as its effect on the length of stay...
March 2012: Revue Médicale de Bruxelles
(no author information available yet)
Introduction to the diet of adult and old rats for 30 days after R-irradiation at a dose of 5 Gy drug "Korargin" prevented the development of some manifestations of radioinduced metabolic syndrome (MS) in animals of both age groups: in adult irradiated animals--a tendency to decrease insulin levels in blood plasma, increase of cholesterol levels in liver tissue, significantly increased serum high density lipoprotein as compared both to controls and irradiated animals, prevented the decrease in the levels of anions NO2- and NO3- in tissue of the aorta and anions NO2- in tissue of the heart; in old irradiated animals--prevented tended to increase of body weight, the increase in insulinresistance (index HOMA), the decrease in the level of anions NO2- in the aorta tissue, increased levels of anions NO2- and NO3- in the heart tissue compared to controls...
October 2011: Likars'ka Sprava
Takashi Kimura, Tsukasa Saito
Myotonic dystrophies (DMs) are autosomal dominant disorders with multisystemic clinical features. DMs are categorized as DM1, caused by a (CTG)n expansion mutation in 19q13, and DM2, caused by a (CCTG)n expansion mutation in 3q21. The clinical features of DM2 are diffuse and proximal dominant weakness, wasting, myotonia, cardiac problems, cataracts, and insulinresistance. DM2 is milder than DM1. We compared the clinical features of both DMs and studied a Japanese patient with DM2 who had expansion mutations different from those usually attributed to the disease and originally discovered by European researchers...
November 2011: Brain and Nerve, Shinkei Kenkyū No Shinpo
V B Simonenko, I N Medvedev, T A Kumova
Hypertension is the main disease in Russian Federation--its frequency is 39.2% in men and 41.1% in women. In recent years course of a disease is accompanied by the metabolic derangements which form the metabolic syndrome. In the basis of pathogenesis of hypertension are insulinresistance and compensatory hyperinsulinemia in combination with associated metabolic derangements. Inveterate insulinresistance leads to hypertension.
September 2010: Voenno-medit︠s︡inskiĭ Zhurnal
M Ruiz Pons, V García Nieto, M Glez García, M García Mérida, C Valenzuela Hdez, A Aguirre-Jaime
UNLABELLED: Ambulatory blood pressure monitoring (ABPM) allows evaluation not only of casual daytime elevations of blood pressure (BP) but also alterations in the 24-hour circadian patterns of BP. The aim of the present study was to assess 24-hour BP patterns in a population of obese children who were referred to our outpatient clinic, in relation to the degree of obesity, body fat distribution and insulin resistance, and considering other cardiovascular risk factors. METHODS: Office and ambulatory BP measurements, and fasting serum glucose, insulin and HOMA determinations were obtained in 119 obese children (7-15 years old)...
2008: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
F Casoinic, D Sâmpelean, Cătălina Badău
UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological condition which ranges from simple steatosis and steatohepatitis to cryptogenetic cirrhosis. As insulinresistance plays a central pathogenetic role, NAFLD is regarded as the hepatic feature of the metabolic syndrome. Type 2 diabetes mellitus and obesity are the conditions most frequently associated with NAFLD. Subclinical inflammation has been suggested as a possible connective mechanism between glycoregulation disorders and NAFLD...
2006: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
Fulya Akin, Mehmet Bastemir, Esma Alkis
This study was performed to evaluate the impact of insulin sensitivity on sex hormone-binding globulin (SHBG) and sex steroids in premenopausal and postmenopausal euthyroid obese women. A total of 227 women were eligible for this study. All were euthyroid, obese, and overweight; ages ranged from 25 to 69 years. Women were divided into premenopausal (n=151) and postmenopausal (n=76) groups. SHBG, sex steroids, thyrotropin, fasting and postprandial glucose, lipid profile, uric acid, serum insulin, and blood pressure were measured...
November 2007: Advances in Therapy
M Zeller, B Vergès, I L'Huillier, J M Brun, Y Cottin
Diabetes is an established major factor of poor prognostis after an acute coronary syndrome. Recent studies have addressed the impact of abnormal glucose metabolism at the acute phase in patients without known diabetes. It has been found that abnormal glycemia regulation is more common than normal regulation in patients presenting with acute coronary syndrome, whatever the method used to evaluate blood glucose metabolism. High blood glucose at admission, whether fasting or not, are associated with worse outcome after an acute coronary syndrome, ie...
September 2006: Diabetes & Metabolism
Piotr Moleda, Liliana Majkowska, Krzysztof Safranow, Grazyna Adler, Iwona Goracy, Krystyna Pilarska
Insulinresistance is a component of the metabolic syndrome and important pathogenetic factor of type 2 diabetes mellitus. There are evidences that activation of the renin-angiotensin system (RAS) can decrease insulin sensitivity of tissues. As I/D polymorphism of angiotensin converting enzyme (ACE) gene can influence the activity of RAS, it may also influence insulin resistance. Aim. To assess the relationship between the I/D polymorphism of ACE gene and degree of insulin resistance and intensity of metabolic syndrome in type 2 diabetic patients...
December 2005: Polskie Archiwum Medycyny Wewnętrznej
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