keyword
MENU ▼
Read by QxMD icon Read
search

Adipocytokines

keyword
https://www.readbyqxmd.com/read/28529612/adipoq-rs266729-g-c-gene-polymorphism-and-plasmatic-adipocytokines-connect-metabolic-syndrome-to-colorectal-cancer
#1
Rosa Divella, Antonella Daniele, Antonio Mazzocca, Ines Abbate, Porzia Casamassima, Cosimo Caliandro, Eustachio Ruggeri, Emanuele Naglieri, Carlo Sabbà, Raffaele De Luca
Background: ADIPOQ gene, which encode for Adiponectin (APN), is sited on chromosome 3q27 and linked to a susceptibility locus for metabolic syndrome (MetS). The ADIPOQ rs266729 G/C gene polymorphism is significantly associated with low APN levels and linked to susceptibility to develop cancer. In addition, decreased APN serum levels are linked with tumor development and progression and inversely associated with markers of inflammation. Here, we investigate the influence of APN rs266729 G/C polymorphism on adipocytokine circulating levels and their association with MetS in colorectal cancer patients (CRC)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28521871/relation-of-antioxidant-capacity-of-diet-and-markers-of-oxidative-status-with-c-reactive-protein-and-adipocytokines-a-prospective-study
#2
Najada Stringa, Adela Brahimaj, Asija Zaciragic, Abbas Dehghan, Mohammad Arfan Ikram, Albert Hofman, Taulant Muka, Jessica C Kiefte-de Jong, Oscar H Franco
BACKGROUND: The role of dietary antioxidants and plasma oxidant-antioxidant status in low-grade chronic inflammation and adipocytokine levels is not established yet. OBJECTIVES: We aimed to evaluate whether total dietary antioxidant capacity (assessed by dietary ferric reducing antioxidant potential (FRAP)), serum uric acid (UA) and gamma glutamyltransferase (GGT) were associated with low-grade chronic inflammation and circulating adipocytokines. METHODS: Data of 4506 participants aged ≥55years from the Rotterdam Study were analyzed...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28508719/kahweol-inhibits-adipogenesis-of-3t3-l1-adipocytes-through-downregulation-of-ppar%C3%AE
#3
Jin Soo Kim, Seul Gi Lee, Young Jin Kang, Taeg Kyu Kwon, Ju-Ock Nam
Kahweol, a compound from Coffea arabica, possesses antioxidant, anti-inflammatory, and antitumour properties. However, an anti-adipogenic effect has not yet been reported. In this study, we have shown that kahweol has an anti-adipogenic effect on 3T3-L1 adipocytes. Kahweol significantly inhibited the differentiation of intracellular lipid accumulation in 3T3-L1 adipocytes, without being cytotoxic. It also downregulated the expression of adipogenesis-related gene, including an adipocytokine, adiponectin. This anti-adipogenic effect stems from an ability to inhibit key adipogenic regulators, including PPARγ and C/EBPα...
May 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28502329/serum-adipocytokine-levels-as-surrogate-markers-for-disease-activity-of-crohn-s-disease
#4
Su Hwan Kim, Seung Hyeon Jang, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, You Sun Kim, Dong Soo Han, Joo Sung Kim
BACKGROUND: Determining inflammatory activity is crucial for assessing disease activity and for tailoring therapy in patients with Crohn׳s disease (CD). This study aimed to evaluate adipocytokine levels in patients with CD and to determine whether they can serve as surrogate markers for disease activity. MATERIALS AND METHODS: Serum samples and information regarding the clinical features of patients in the CD Network Project registry were collected from March 2009 to February 2012...
May 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28500659/insulin-sensitivity-in-relation-to-fat-distribution-and-plasma-adipocytokines-among-abusers-of-anabolic-androgenic-steroids
#5
Jon Jarløv Rasmussen, Morten Schou, Christian Selmer, Marie Louise Johansen, Finn Gustafsson, Jan Frystyk, Flemming Dela, Jens Faber, Caroline Kistorp
OBJECTIVE: Abuse of anabolic androgenic steroids (AAS) is prevalent among young men, but information regarding effects on insulin sensitivity and fat distribution is limited. The objective was to investigate insulin sensitivity in relation to fat distribution and adipocytokines among current and former AAS abusers compared with controls. DESIGN: Cross-sectional study among men involved in recreational strength training. Current and former AAS abusers (n=37 and n=33) and controls (n=30) volunteered from the community...
May 13, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28482269/skeletal-growth-and-bone-mineral-acquisition-in-type-1-diabetic-children-abnormalities-of-the-gh-igf-1-axis
#6
REVIEW
Manish Raisingani, Brar Preneet, Brenda Kohn, Shoshana Yakar
Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases diagnosed in childhood. Childhood and adolescent years are also the most important period for growth in height and acquisition of skeletal bone mineral density (BMD). The growth hormone (GH)/insulin like growth factor -1 (IGF-1) axis which regulates growth, is affected by T1DM, with studies showing increased GH and decreased IGF-1 levels in children with T1DM. There is conflicting data as to whether adolescents with TIDM are able to achieve their genetically-determined adult height...
April 28, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28465145/energy-sensing-pathways-bridging-type-2-diabetes-and-colorectal-cancer
#7
REVIEW
Juhong Yang, Reiko Nishihara, Xuehong Zhang, Shuji Ogino, Zhi Rong Qian
The recently rapid increase of obesity and type 2 diabetes mellitus has caused great burden to our society. A positive association between type 2 diabetes and risk of colorectal cancer has been reported by increasing epidemiological studies. The molecular mechanism of this connection remains elusive. However, type 2 diabetes may result in abnormal carbohydrate and lipid metabolism, high levels of circulating insulin, insulin growth factor-1, and adipocytokines, as well as chronic inflammation. All these factors could lead to the alteration of energy sensing pathways such as the AMP activated kinase (PRKA), mechanistic (mammalian) target of rapamycin (mTOR), SIRT1, and autophagy signaling pathways...
April 13, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28465000/long-term-soft-drink-and-aspartame-intake-induces-hepatic-damage-via-dysregulation-of-adipocytokines-and-alteration-of-the-lipid-profile-and-antioxidant-status
#8
Mohamed A Lebda, Hossam G Tohamy, Yasser S El-Sayed
Dietary intake of fructose corn syrup in sweetened beverages is associated with the development of metabolic syndrome and obesity. We hypothesized that inflammatory cytokines play a role in lipid storage and induction of liver injury. Therefore, this study intended to explore the expression of adipocytokines and its link to hepatic damage. Rats were assigned to drink water, cola soft drink (free access) and aspartame (240 mg/kg body weight/day orally) for 2 months. The lipid profiles, liver antioxidants and pathology, and mRNA expression of adipogenic cytokines were evaluated...
April 19, 2017: Nutrition Research
https://www.readbyqxmd.com/read/28464792/detection-and-comparison-of-micrornas-in-the-caprine-mammary-gland-tissues-of-colostrum-and-common-milk-stages
#9
Jinxing Hou, Xiaopeng An, Yuxuan Song, Binyun Cao, Heping Yang, Zhou Zhang, Wenzheng Shen, Yunpu Li
BACKGROUND: MicroRNAs (miRNAs) have a great influence on various physiological functions. A lot of high-throughput sequencing (HTS) research on miRNAs has been executed in the caprine mammary gland at different lactation periods (common milk lactation and dry period), but little is known about differentially expressed miRNAs in the caprine mammary gland of colostrum and peak lactation periods. RESULT: This study identified 131 differentially expressed miRNAs (P < 0...
May 2, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28453868/combined-aerobic-and-resistance-training-decreases-inflammation-markers-in-healthy-men
#10
J K Ihalainen, M Schumann, D Eklund, M Hämäläinen, E Moilanen, G Paulsen, K Häkkinen, A A Mero
BACKGROUND AND AIMS: Our primary aim was to study the effects of 24 weeks of combined aerobic and resistance training performed on the same day or on different days on inflammation markers. METHODS AND RESULTS: Physically active, healthy young men were randomly divided into three groups that performed: aerobic and resistance training consecutively in the same training session (SS) 2-3 d·wk(-1) or on alternating days (AD) 4-6 d·wk(-1) as well as control (C). The total training volume was matched in the training groups...
April 28, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28447033/prokineticin-is-a-new-linker-between-obesity-and-cardiovascular-diseases
#11
REVIEW
Canan G Nebigil
Obesity is a fast growing epidemic event worldwide. Fatness is associated with a number of comorbidities, including cardiovascular diseases (CVDs). Although obesity can be heredity in 30-70% cases, the environmental contributions also play an important role in the increasing prevalence of obesity. The relationship between development of obesity and CVD is poorly characterized. Obesity and CVD can also be resulted from a common mechanism such as metabolic, inflammatory, and neurohormonal changes. Prokineticins are defined as cytokines (immunoregulatory proteins), adipokines (adipocyte-secreted hormone), angiogenic (increasing vessel formation), or aneroxic (lowering food intake) hormones...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28431918/gender-dependent-effects-of-fasting-blood-glucose-levels-and-disease-duration-on-biochemical-markers-in-type-2-diabetics-a-pilot-study
#12
Abhijit A Ghadge, Arundhati G Diwan, Abhay M Harsulkar, Aniket A Kuvalekar
AIM: The impact of fasting blood glucose levels (FBG) and disease duration on type 2 diabetes in Indian population is still unclear. The present study examines gender-dependent effects of FBG and disease duration on lipid profile, adipocytokines and related biochemical parameters in diabetic individuals. METHODS: Type 2 diabetic individuals (n=100) were classified depending on FBG: patients with normal FBG (Glucose<126mg/dl) and patients with high FBG (Glucose≥126mg/dl); and disease duration: ≥0-≤3yr, >3-≤7yr, >7yr...
April 7, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28424792/sustained-high-levels-of-both-total-and-high-molecular-weight-adiponectin-in-plasma-during-the-convalescent-phase-of-haemorrhagic-fever-with-renal-syndrome-are-associated-with-disease-severity
#13
Kang Tang, Chunmei Zhang, Yusi Zhang, Yun Zhang, Ran Zhuang, Boquan Jin, Ying Ma
Haemorrhagic fever with renal syndrome (HFRS) is characterised by an uncontrolled immune response that causes vascular leakage. Adiponectin (APN) is an adipocytokine involved in prorevascularisation and immunomodulation. To investigate the possible effects of APN in the pathogenesis of HFRS, total and high molecular weight (HMW) APN levels in the plasma of patients with HFRS were quantified using enzyme-linked immunosorbent assay (ELISA). Compared with those in healthy controls, the plasma total and HMW APN levels in patients were elevated to different degrees from the fever onset and remained high at the convalescent phase...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28414093/imbalance-in-leptin-adiponectin-levels-and-leptin-receptor-expression-as-chief-contributors-to-triple-negative-breast-cancer-progression-in-northeast-india
#14
Rizwana Sultana, Amal Ch Kataki, Bibhuti Bhusan Borthakur, Tarun K Basumatary, Sujoy Bose
BACKGROUND: Triple-Negative breast cancer (TNBC), accounts for a large percentage of breast cancer cases in India including Northeast India. TNBC has an unclear molecular aetiology and hence limited targeted therapies. Human breast is comprised of glandular, ductal, connective, and adipose tissues. Adipose tissue is composed of adipocytes. The adipocytes apart from being energy storage depots, are also active sources of adipocytokines and/or adipokines. The role of adipokines in breast cancer including TNBC has been sporadically documented...
July 20, 2017: Gene
https://www.readbyqxmd.com/read/28405802/vasculo-protective-effect-of-bms-309403-is-independent-of-its-specific-inhibition-of-fatty-acid-binding-protein-4
#15
Yuta Okamura, Kosuke Otani, Akihiro Sekiguchi, Taisuke Kogane, Chiharu Kakuda, Yuzaburo Sakamoto, Tomoko Kodama, Muneyoshi Okada, Hideyuki Yamawaki
Fatty acid-binding protein (FABP) 4 is an adipocytokine mainly expressed in adipocyte and macrophage. Blood FABP4 is related not only to metabolic disorders including insulin resistance and atherosclerosis but also increased blood pressure. We tested the hypothesis that FABP4 plays roles in pathogenesis of hypertension development including proliferation, migration, and inflammation of vascular smooth muscle cells (SMCs) as well as contractile reactivity. FABP4 alone had no influence on proliferation, migration, and inflammation of rat mesenteric arterial SMCs, while it significantly enhanced smooth muscle contraction and increases of systolic blood pressure (SBP) induced by noradrenaline (NA)...
April 13, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28399156/presence-of-il-17-in-synovial-fluid-identifies-a-potential-inflammatory-osteoarthritic-phenotype
#16
Sarah J B Snelling, Sylvette Bas, Gabor J Puskas, Stephanie G Dakin, Domizio Suva, Axel Finckh, Cem Gabay, Pierre Hoffmeyer, Andrew J Carr, Anne Lübbeke
PURPOSE: Osteoarthritis (OA) is a common and heterogeneous arthritic disorder. Patients suffer pain and their joints are characterized by articular cartilage loss and osteophyte formation. Risk factors for OA include age and obesity with inflammation identified as a key mediator of disease pathogenesis. Interleukin-17A (IL-17) is a pro-inflammatory cytokine that has been implicated in inflammatory diseases such as rheumatoid arthritis. IL-17 can upregulate expression of inflammatory cytokines and adipocytokines...
2017: PloS One
https://www.readbyqxmd.com/read/28395518/intracerebroventricular-administration-of-adiponectin-attenuates-streptozotocin-induced-memory-impairment-in-rats
#17
R Mazrooie, K Rohampour, M Zamani, N Hosseinmardi, M Zeraati
Alzheimer's disease (AD) has been reported to be linked with diabetes mellitus and insulin resistance. Adiponectin (ADN), an adipocytokine secreted from adipose tissue, is involved in the regulation of insulin sensitivity, energy homeostasis, and mitochondrial dysfunction. In this study, we examined the effect of ADN on passive avoidance memory in animal model of sporadic AD (sAD). On days 1 and 3 after cannulation, rats received intracerebroventricular (icv) injection of streptozotocin (STZ) (3 mg/kg). Thirty minutes before the learning process, animals received saline or ADN in different doses (6, 60, and 600 µg)...
April 11, 2017: Physiology International
https://www.readbyqxmd.com/read/28387741/effects-of-low-molecular-weight-fucoidan-and-high-stability-fucoxanthin-on-glucose-homeostasis-lipid-metabolism-and-liver-function-in-a-mouse-model-of-type-ii-diabetes
#18
Hong-Ting Victor Lin, Yu-Chi Tsou, Yu-Ting Chen, Wen-Jung Lu, Pai-An Hwang
The combined effects of low-molecular-weight fucoidan (LMF) and fucoxanthin (Fx) in terms of antihyperglycemic, antihyperlipidemic, and hepatoprotective activities were investigated in a mouse model of type II diabetes. The intake of LMF, Fx, and LMF + Fx lowered the blood sugar and fasting blood sugar levels, and increased serum adiponectin levels. The significant decrease in urinary sugar was only observed in LMF + Fx supplementation. LMF and Fx had ameliorating effects on the hepatic tissue of db/db mice by increasing hepatic glycogen and antioxidative enzymes, and LMF was more effective than Fx at improving hepatic glucose metabolism...
April 7, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28360082/adipose-tissue-supports-normalization-of-macrophage-and-liver-lipid-handling-in-obesity-reversal
#19
Maayan Vatarescu, Sapir Bechor, Yulia Haim, Tal Pecht, Tanya Tarnovsky, Noa Slutsky, Ori Nov, Hagit Shapiro, Avishai Shemesh, Angel Porgador, Nava Bashan, Assaf Rudich
Adipose tissue inflammation and dysfunction are considered central in the pathogenesis of obesity-related dys-metabolism, but their role in the rapid metabolic recovery upon obesity reversal is less well-defined. We hypothesized that changes in adipose tissue endocrine and paracrine mechanisms may support the rapid improvement of obesity-induced impairment in cellular lipid handling. C57Bl-6J mice were fed ad-libitum either normal chow (NC) or high-fat diet (HFF) for 10 weeks. A dietary obesity reversal group was fed HFF for 8 weeks, then switched to NC for 2 weeks (HFFNC)...
March 30, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28356939/identification-of-genes-associated-with-tongue-cancer-in-patients-with-a-history-of-tobacco-and-or-alcohol-use
#20
Yin Zhao, Dongna Fu, Chengbi Xu, Jingpu Yang, Zonggui Wang
The present study aimed to identify genes associated with tongue cancer in patients with a history of tobacco and/or alcohol use. Microarray dataset GSE42023, including 10 tissue samples of tongue cancer from patients with a history of tobacco and/or alcohol use (habit group) and 11 tissue samples of non-habit-associated tongue cancer (non-habit group), were downloaded from the Gene Expression Omnibus database. Differentially-expressed genes (DEGs) between the habit and non-habit groups were identified using the Linear Models for Microarray Data software package...
February 2017: Oncology Letters
keyword
keyword
50892
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"