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Adipocytokines

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https://www.readbyqxmd.com/read/28635626/adiponectin-a-therapeutic-target-for-obesity-diabetes-and-endothelial-dysfunction
#1
REVIEW
Arunkumar E Achari, Sushil K Jain
Adiponectin is the most abundant peptide secreted by adipocytes, whose reduction plays a central role in obesity-related diseases, including insulin resistance/type 2 diabetes and cardiovascular disease. In addition to adipocytes, other cell types, such as skeletal and cardiac myocytes and endothelial cells, can also produce this adipocytokine. Adiponectin effects are mediated by adiponectin receptors, which occur as two isoforms (AdipoR1 and AdipoR2). Adiponectin has direct actions in liver, skeletal muscle, and the vasculature...
June 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28625041/energy-regulation-in-newly-diagnosed-tb-with-chronic-energy-deficiency-free-fatty-acids-and-rbp4
#2
Nurpudji A Taslim, Devintha Virani, Ni Ketut Sumartini, Karmila, Agussalim Bukhari, Aminuddin, Suryani As'ad, Raden Satriono, Haerani Rasyid, Irawaty Djaharuddin
BACKGROUND AND OBJECTIVES: Energy metabolism may be dysfunctionally integral between host and infective agent in active tuberculosis, mediated by adipocytokines and free fatty acids (FFA) as the products of triglyceride lipolysis in fat, blood or other tissues. Retinol Binding Protein 4 (RBP4) and asymmetric dimethylarginine (ADMA) are candidate adipocytokines. The possibility of a deleterious metabolic nexus in chronic energy deficiency (CED) (BMI <18.5 kg/m2) is explored. METHODS AND DESIGN: Newly diagnosed patients with tuberculosis (n=63) were selected using consecutive random sampling at a Centre for the Care and Treatment of Lung Diseases in Makassar, Indonesia...
June 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28624657/adiponectin-improves-the-osteointegration-of-titanium-implant-under-diabetic-conditions-by-reversing-mitochondrial-dysfunction-via-the-ampk-pathway-in-vivo-and-in-vitro
#3
Xiao-Fan Hu, Lin Wang, Yi-Zhao Lu, Geng Xiang, Zi-Xiang Wu, Ya-Bo Yan, Yang Zhang, Xiong Zhao, Yuan Zang, Lei Shi, Wei Lei, Ya-Fei Feng
Diabetes-induced reactive oxygen species (ROS) overproduction would result in compromised osteointegration of titanium implant (TI) and high rate of implant failure, yet the underlying mechanisms remain elusive. Adiponectin (APN) is a fat-derived adipocytokine with strong antioxidant, mitochondrial-protective and anti-diabetic efficacies. We hypothesized that mitochondrial dysfunction under diabetes may account for the oxidative stress in osteoblasts and titanium-bone interface (TBI) instability, which could be ameliorated by APN...
June 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28601889/rna-sequence-analysis-reveals-differentially-expressed-genes-degs-in-patients-exhibiting-different-risks-of-tumor-metastasis
#4
Li-Feng Dong, Shu-Ying Xu, Jing-Pei Long, Fang Wan, Yi-Ding Chen
BACKGROUND Breast cancer is one of the most common malignancies in women. In a previous study, we found that for two patients who had a high risk of lymphatic metastasis, lymphatic metastasis did not occur; whereas, for two patients who had a low risk of lymphatic metastasis, lymphatic metastasis did occur. MATERIAL AND METHODS We analyzed the differential gene expressions of these four patients by RNA-sequence. The data (HRNM_T versus HRNM_N, LRYM_T versus LRYM_N, and HRNM_T versus LRYM_T) was then processed using differentially expressed genes (DEGs) analysis, functional analysis for DEGs, and PPI network construct...
June 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28595284/infertility-diagnosis-has-a-significant-impact-on-the-transcriptome-of-developing-blastocysts
#5
Blair R McCallie, Jason C Parks, Darren K Griffin, William B Schoolcraft, Mandy G Katz-Jaffe
STUDY QUESTION: Is the human blastocyst transcriptome associated with infertility diagnosis, specifically: polycystic ovaries (PCO), male factor (MF), and unexplained (UE)? SUMMARY ANSWER: The global blastocyst transcriptome was significantly altered in association with a PCO, MF, and UE infertility diagnosis. WHAT IS KNOWN ALREADY: Infertility diagnosis has an impact on the probability for a successful outcome following an IVF cycle. Limited information is known regarding the relationship between a specific infertility diagnosis and blastocyst transcription during pre-implantation development...
June 8, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28589911/comparative-analyses-of-long-non-coding-rna-in-lean-and-obese-pig
#6
Lin Yu, Lina Tai, Lifang Zhang, Yi Chu, Yixing Li, Lei Zhou
OBJECTIVES: Current studies have revealed that long non-coding RNA plays a crucial role in fat metabolism. However, the difference of lncRNA between lean (Duroc) and obese (Luchuan) pig remain undefined. Here, we investigated the expressional profile of lncRNA in these two pigs and discussed the relationship between lncRNA and fat deposition. MATERIALS AND METHODS: The Chinese Luchuan pig has a dramatic differences in backfat thickness as compared with Duroc pig...
May 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28587104/c1q-tnf-related-protein-9-ameliorates-ox-ldl-induced-endothelial-dysfunction-via-pgc-1%C3%AE-ampk-mediated-antioxidant-enzyme-induction
#7
Haijian Sun, Xuexue Zhu, Yuetao Zhou, Weiwei Cai, Liying Qiu
Oxidized low-density lipoprotein (ox-LDL) accumulation is one of the critical determinants in endothelial dysfunction in many cardiovascular diseases such as atherosclerosis. C1q/TNF-related protein 9 (CTRP9) is identified to be an adipocytokine with cardioprotective properties. However, the potential roles of CTRP9 in endothelial function remain largely elusive. In the present study, the effects of CTRP9 on the proliferation, apoptosis, migration, angiogenesis, nitric oxide (NO) production and oxidative stress in human umbilical vein endothelial cells (HUVECs) exposed to ox-LDL were investigated...
May 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28585205/adipose-tissue-hypoxia-in-obesity-and-its-impact-on-preadipocytes-and-macrophages-hypoxia-hypothesis
#8
Atilla Engin
Obese subjects exhibit lower adipose tissue oxygen consumption in accordance with the lower adipose tissue blood flow. Thus, compared with lean subjects, obese subjects have 44% lower capillary density and 58% lower vascular endothelial growth factor (VEGF). The VEGF expression together with hypoxia-inducible transcription factor-1 (HIF-1) activity also requires phosphatidylinositol 3-kinase (PI3K)- and target of rapamycin (TOR)-mediated signaling. HIF-1alpha is an important signaling molecule for hypoxia to induce the inflammatory responses...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28585194/circadian-rhythms-in-diet-induced-obesity
#9
Atilla Engin
The biological clocks of the circadian timing system coordinate cellular and physiological processes and synchronizes these with daily cycles, feeding patterns also regulates circadian clocks. The clock genes and adipocytokines show circadian rhythmicity. Dysfunction of these genes are involved in the alteration of these adipokines during the development of obesity. Food availability promotes the stimuli associated with food intake which is a circadian oscillator outside of the suprachiasmatic nucleus (SCN)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28578188/children-s-cortisol-and-externalizing-stress-symptoms-are-predictors-of-adiponectin-evolution-over-two-years
#10
Nathalie Michels, Isabelle Sioen, Kirsten Schraven, Annelies De Decker, Carola van Aart, Stefaan De Henauw
BACKGROUND: Adiponectin is an anti-inflammatory, insulin-sensitizing and energy-regulating adipocytokine. Consequently, the link between psychosocial stress and inflammatory diseases like the metabolic syndrome might be partially explained by lower adiponectin levels in stress. Nevertheless, the stress-adiponectin association has seldom been tested and no clarity exists about the directionality. METHODS: In the Belgian ChiBS study, serum adiponectin and stress levels were measured in 348 children (5-10y) at baseline and in 168 of them after 2-year follow-up...
May 31, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28577872/association-of-adiponectin-with-subclinical-atherosclerosis-in-a-mexican-mestizo-population
#11
Juan Gabriel Juárez-Rojas, Rosalinda Posadas-Sánchez, María Del Rocío Martínez-Alvarado, Margarita Torres-Tamayo, Esteban Jorge-Galarza, Erika Yamel Mancilla-Valenzuela, Carlos Posadas-Romero, Guillermo Celestino Cardoso-Saldaña, María Del Carmen González-Salazar, Gilberto Vargas-Alarcón, Aida Xochitl Medina-Urrutia
BACKGROUND AND AIMS: Adiponectin (ADPN) is a cardioprotective adipocytokine, and its association with atherosclerosis development is controversial. The aim of the present study was to assess the association of low ADPN plasma levels with the presence of subclinical atherosclerosis in a Mexican-Mestizo population without history of diabetes or coronary artery disease (CAD). METHODS: In 818 subjects (53.4 ± 9 years; 49.9% women) anthropometry, subcutaneous and visceral adipose tissue, lipids, glucose, C-reactive protein (CRP), insulin, and ADPN levels were determined...
January 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28577342/lower-shbg-level-is-associated-with-higher-leptin-and-lower-adiponectin-levels-as-well-as-metabolic-syndrome-independent-of-testosterone
#12
Chia-Chu Liu, Shu-Pin Huang, Kai-Hung Cheng, Tusty-Jiuan Hsieh, Chun-Nung Huang, Chii-Jye Wang, Hsin-Chih Yeh, Chia-Chun Tsai, Bo-Ying Bao, Wen-Jeng Wu, Yung-Chin Lee
In addition to testosterone (T), the emerging role of sex hormone-binding globulin (SHBG) in pathogenesis of metabolic syndrome (MetS) has been noted recently. However, reports of associations with serum adipocytokine levels are still limited. Therefore, we conducted this study to evaluate whether serum T and SHBG levels are independent predictors for the risk of MetS that are associated with adiponectin and leptin levels in 614 Taiwanese men over 40 years old collected from a free health screening. Subjects in the lowest quartile of TT and SHBG levels are exposed to a 1...
June 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28573064/nonalcoholic-fatty-liver-disease-diagnostic-biomarkers
#13
REVIEW
Fatemeh Hadizadeh, Elham Faghihimani, Peyman Adibi
Nonalcoholic fatty liver disease is a common medical condition worldwide and its prevalence has increased notably in the past few years due to the increases in prevalence of obesity and metabolic syndrome. However, diagnosis of this disease is still a matter of debate because of disease variations and pathophysiologic alterations. Specific single markers have gained considerable attention recently, among them markers related to hepatic pathophysiology, inflammation, adipocytokines and so forth. But, it seems that no single marker is sufficient for diagnosis and staging of the disease, and applying a panel including different types of tests may be more useful...
May 15, 2017: World Journal of Gastrointestinal Pathophysiology
https://www.readbyqxmd.com/read/28572048/the-role-of-endothelial-cells-in-the-vasculopathy-of-systemic-sclerosis-a-systematic-review
#14
REVIEW
Y Mostmans, M Cutolo, C Giddelo, S Decuman, K Melsens, H Declercq, E Vandecasteele, F De Keyser, O Distler, J Gutermuth, V Smith
INTRODUCTION: Systemic sclerosis (SSc) is an autoimmune connective tissue disorder characterized by fibroproliferative vasculopathy, immunological abnormalities and progressive fibrosis of multiple organs including the skin. In this study, all English speaking articles concerning the role of endothelial cells (ECs) in SSc vasculopathy and representing biomarkers are systematically reviewed and categorized according to endothelial cell (EC) (dys)function in SSc. METHODS: A sensitive search on behalf of the EULAR study group on microcirculation in Rheumatic Diseases was developed in Pubmed, The Cochrane Library and Web of Science to identify articles on SSc vasculopathy and the role of ECs using the following Mesh terms: (systemic sclerosis OR scleroderma) AND pathogenesis AND (endothelial cells OR marker)...
May 29, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28569359/early-effects-of-sleeve-gastrectomy-on-obesity-related-cytokines-and-bile-acid-metabolism-in-morbidly-obese-japanese-patients
#15
Hideharu Shimizu, Fumihiko Hatao, Kazuhiro Imamura, Kijuro Takanishi, Motoyoshi Tsujino
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has wide-ranging positive effects on adipocytokine metabolism, bile acid profile, and chronic low-grade inflammation related to obesity. However, the early temporal changes in these markers following LSG have not been well investigated. This study aimed to evaluate the early effects of LSG on adipocytokines, bile acid profile, and inflammatory markers. METHODS: This was a nonrandomized prospective study examining morbidly obese Japanese patients undergoing LSG...
May 31, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28553078/effects-of-metformin-extended-release-compared-to-immediate-release-formula-on-glycemic-control-and-glycemic-variability-in-patients-with-type-2-diabetes
#16
Giuseppe Derosa, Angela D'Angelo, Davide Romano, Pamela Maffioli
PURPOSE: The purpose of this study is to evaluate, in a randomized clinical trial, the effects of metformin immediate release (IR) compared with metformin extended release (XR) on the gastrointestinal tolerability and glycemic control. MATERIALS AND METHODS: We enrolled 253 Caucasian patients with type 2 diabetes not well controlled by diet (glycated hemoglobin [HbA1c] >7.0% and <8.5%). Patients were randomized to metformin IR or metformin XR for a period of 6 months at the maximum tolerated dose...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28544198/jaboticaba-berry-peel-intake-prevents-insulin-resistance-induced-tau-phosphorylation-in-mice
#17
Ângela G Batista, Edilene S Soares, Monique C P Mendonça, Juliana K da Silva, Ana Paula Dionísio, Cesar R Sartori, Maria Alice da Cruz-Höfling, Mário R Maróstica Júnior
The hyperphosphorylation of tau in the hippocampus can be caused by central and peripheral insulin resistance and these alterations are related to the development of tauopathies, such as Alzheimer's disease. In this study, we used a high-fat diet to induce obesity and insulin resistance in adult Swiss mice and checked whether supplementation with Myrciaria jaboticaba berry peel for 10 weeks could improve insulin sensitivity, learning/memory performance and prevent tau phosphorylation in the hippocampus. Furthermore, adipocytokines, inflammatory markers, and oxidative stress were assessed...
May 19, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28529612/adipoq-rs266729-g-c-gene-polymorphism-and-plasmatic-adipocytokines-connect-metabolic-syndrome-to-colorectal-cancer
#18
Rosa Divella, Antonella Daniele, Antonio Mazzocca, Ines Abbate, Porzia Casamassima, Cosimo Caliandro, Eustachio Ruggeri, Emanuele Naglieri, Carlo Sabbà, Raffaele De Luca
Background: ADIPOQ gene, which encode for Adiponectin (APN), is sited on chromosome 3q27 and linked to a susceptibility locus for metabolic syndrome (MetS). The ADIPOQ rs266729 G/C gene polymorphism is significantly associated with low APN levels and linked to susceptibility to develop cancer. In addition, decreased APN serum levels are linked with tumor development and progression and inversely associated with markers of inflammation. Here, we investigate the influence of APN rs266729 G/C polymorphism on adipocytokine circulating levels and their association with MetS in colorectal cancer patients (CRC)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28521871/relation-of-antioxidant-capacity-of-diet-and-markers-of-oxidative-status-with-c-reactive-protein-and-adipocytokines-a-prospective-study
#19
Najada Stringa, Adela Brahimaj, Asija Zaciragic, Abbas Dehghan, Mohammad Arfan Ikram, Albert Hofman, Taulant Muka, Jessica C Kiefte-de Jong, Oscar H Franco
BACKGROUND: The role of dietary antioxidants and plasma oxidant-antioxidant status in low-grade chronic inflammation and adipocytokine levels is not established yet. OBJECTIVES: We aimed to evaluate whether total dietary antioxidant capacity (assessed by dietary ferric reducing antioxidant potential (FRAP)), serum uric acid (UA) and gamma glutamyltransferase (GGT) were associated with low-grade chronic inflammation and circulating adipocytokines. METHODS: Data of 4506 participants aged ≥55years from the Rotterdam Study were analyzed...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28508719/kahweol-inhibits-adipogenesis-of-3t3-l1-adipocytes-through-downregulation-of-ppar%C3%AE
#20
Jin Soo Kim, Seul Gi Lee, Young Jin Kang, Taeg Kyu Kwon, Ju-Ock Nam
Kahweol, a compound from Coffea arabica, possesses antioxidant, anti-inflammatory, and antitumour properties. However, an anti-adipogenic effect has not yet been reported. In this study, we have shown that kahweol has an anti-adipogenic effect on 3T3-L1 adipocytes. Kahweol significantly inhibited the differentiation of intracellular lipid accumulation in 3T3-L1 adipocytes, without being cytotoxic. It also downregulated the expression of adipogenesis-related gene, including an adipocytokine, adiponectin. This anti-adipogenic effect stems from an ability to inhibit key adipogenic regulators, including PPARγ and C/EBPα...
May 16, 2017: Natural Product Research
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