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Adipocytokines

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https://www.readbyqxmd.com/read/29132244/adipocytokines-and-ghrelin-level-of-bipolar-patients-from-manic-episode-to-euthymic-episode
#1
Özgür Korhan Tunçel, Gökhan Sarısoy, Birşen Bilgici, Ozan Pazvantoğlu, Eda Çetin, Ebru Kaynar Tunçel
PURPOSE: Obesity and metabolic syndrome (MeS) are more frequently observed in bipolar patients than the general population. This may result from the differences of adipocytokines and ghrelin levels in bipolar disorder. MATERIAL AND METHODS: We evaluated the leptin, adiponectin, resistin and ghrelin levels in bipolar patients (n = 30) in manic episode and in a control group (n = 30). After treatment, the same patients were evaluated again during the euthymic episode...
November 13, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29101069/association-between-fto-gene-polymorphisms-and-type-2-diabetes-mellitus-serum-levels-of-apelin-and-androgen-hormones-among-iranian-obese-women
#2
Farzaneh Ghafarian Alipour, Shayan Ziaee, Mohamad Reza Ashoori, Mir Saeid Zakeri, Mohammad Ali Boroumand, Naser Aghamohammadzadeh, Maryam Abbasi-Majdi, Fatemeh Shool, Navid Sarakhs Asbaghi, Abolghasem Mohammadi, Nosratollah Zarghami
BACKGROUND AND AIMS: Recent studies show that FTO single nucleotide polymorphisms (SNPs) are associated with obesity and type 2 diabetes mellitus (T2DM). On the other hand, many animal models and clinical studies have demonstrated that apelin, an adipocytokine, is related to the obesity and T2DM. Additionally, obese women are at risk of Hyperandrogenemia. So, the aim of this study was to investigate the relationship between FTO variants (rs763967273, rs759031579, rs141115189, rs9926289, rs76804286 and rs9939609) with T2DM, serum apelin and androgenic hormones in Iranian obese women...
October 31, 2017: Gene
https://www.readbyqxmd.com/read/29081341/dna-methylation-and-birth-weight-a-genome-wide-analysis
#3
Li Li Mao, Xin Hua Xiao, Qian Zhang, Jia Zheng, Wen Hui Li, Miao Yu, Hua Bing Zhang, Fan Ping, Jian Ping Xu, Xiao Jing Wang
The study illustrate the inner correlation between global DNA methylation variation and different birth weights. Infant birth weight was used to identify cases and controls. Cord blood and placentas were collected. We performed DNA methylation profiling of bisulphite-converted DNA. We have identified many differentially methylated CpG sites in experimental groups; these sites involved in hundreds of signalings. Among these, more than ten pathways were referred to the glucose and lipid metabolism. Methylation changes in the insulin-signaling pathway (ISP), adipocytokine signaling pathway (ASP) and MAPK signaling pathway are involved in the fetal programming of diabetes...
September 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29066788/periodontal-pathogenic-bacteria-aggregatibacter-actinomycetemcomitans-affect-non-alcoholic-fatty-liver-disease-by-altering-gut-microbiota-and-glucose-metabolism
#4
Rina Komazaki, Sayaka Katagiri, Hirokazu Takahashi, Shogo Maekawa, Takahiko Shiba, Yasuo Takeuchi, Yoichiro Kitajima, Anri Ohtsu, Sayuri Udagawa, Naoki Sasaki, Kazuki Watanabe, Noriko Sato, Naoyuki Miyasaka, Yuichiro Eguchi, Keizo Anzai, Yuichi Izumi
Increasing evidence indicates that periodontitis affects non-alcoholic fatty liver disease (NAFLD). We examined the relationship between periodontal bacterial infection and clinical/biochemical parameters in 52 NAFLD patients. Anti-Aggregatibacter actinomycetemcomitans (Aa) antibody titers correlated positively with visceral fat, fasting plasma insulin, and HOMA-IR; and negatively with the liver/spleen ratio. C57BL/6J mice (8-weeks-old) were given Aa or saline (control) for 6 weeks, and were fed either normal chow (NCAa, NCco) or high-fat diet (HFAa and HFco)...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29062839/antidiabetic-effect-of-brain-derived-neurotrophic-factor-and-its-association-with-inflammation-in-type-2-diabetes-mellitus
#5
REVIEW
Ceren Eyileten, Agnieszka Kaplon-Cieslicka, Dagmara Mirowska-Guzel, Lukasz Malek, Marek Postula
Brain-derived neurotrophic factor (BDNF) is a neurotrophin, which plays an important role in the central nervous system, and systemic or peripheral inflammatory conditions, such as acute coronary syndrome and type 2 diabetes mellitus (T2DM). BDNF is also expressed in several nonneuronal tissues, and platelets are the major source of peripheral BDNF. Here, we reviewed the potential role of BDNF in platelet reactivity in T2DM and its association with selected inflammatory and platelet activation mediators. Besides that, we focused on adipocytokines such as leptin, resistin, and adiponectin which are considered to take part in inflammation and both lipid and glucose metabolism in diabetic patients as previous studies showed the relation between adipocytokines and BDNF...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29061179/effect-of-whey-protein-supplementation-on-levels-of-endocannabinoids-and-some-of-metabolic-risk-factors-in-obese-women-on-a-weight-loss-diet-a-study-protocol-for-a-randomized-controlled-trial
#6
Fatemeh Haidari, Vahideh Aghamohammadi, Majid Mohammadshahi, Kambiz Ahmadi-Angali
BACKGROUND: Besides the effects of dietary long chain PUFA on circulating endocannabinoids concentrations, the impact of other nutrients on these system is not known and, whether changes in plasma endocannabinoids levels correlated with changes in body composition and biochemical metabolic risk factors in obese individuals, however, still remains to be characterized. METHODS: We will conduct a 2 months' open label, parallel-group, randomized controlled trial to determine the effect of whey protein supplementation on levels of endocannabinoids, glycemic and lipid profile, inflammatory factors, adipocytokines and body composition in 60 premenopausal obese women on a weight-loss diet...
October 23, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/29053943/inflammation-status-of-healthy-young-men-initial-and-specific-responses-to-resistance-training
#7
Johanna K Ihalainen, Heikki Peltonen, Göran Paulsen, Juha P Ahtiainen, Ritva S Taipale, Mari Hämäläinen, Eeva Moilanen, Antti A Mero
PURPOSE: Our primary aim was to study the effects of a 4 wk preparatory resistance training (RT) period followed by 12 wks of two specific RT protocols (either hypertrophic-strength, HS, or strength-hypertrophy-power, SHP, training) on inflammation markers and the possible relationship of the changes in abdominal fat and lean mass to the changes in inflammation status. METHODS: A total of 82 healthy men were included in the study. Maximal concentric leg press strength (1RM), total body lean mass, total body and abdominal fat mass, circulating high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra), monocyte chemoattractant protein 1 (MCP-1), and selected adipocytokines (resistin, adiponectin and leptin) concentrations were measured before (PRE) and after 4 (wk4) and 16 weeks (wk16) of RT...
October 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29048406/disparity-in-fetal-growth-between-twin-and-singleton-gestation-the-role-of-adipokines
#8
R Zemet, Y Shulman, R Hemi, B Brandt, E Sivan, H Kanety, S Mazaki-Tovi
OBJECTIVE: Twin pregnancies are characterized by unique pattern of attenuated fetal weight gain during late gestation compared with singleton gestation. The mechanism(s) responsible for regulating twin growth has not yet elucidated. Leptin and adiponectin are two adipocytokines implicated in metabolism and energy balance of fetuses, newborns and adults. Moreover, these hormones have been suggested to play a role in fetal growth. The objective of the study was to determine cord blood adiponectin and leptin in twins and singletons, with and without growth impairment...
October 19, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29034787/role-of-adipocytokines-in-the-pathophysiology-of-migraine-a-cross-sectional-study
#9
Clara Dominguez, Alba Vieites-Prado, Maria Perez-Mato, Tomas Sobrino, Xiana Rodriguez-Osorio, Ana Lopez, Francisco Campos, Francisco Martinez, Jose Castillo, Rogelio Leira
No abstract text is available yet for this article.
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29033577/are-adipocytokines-inflammatory-or-metabolic-mediators-in-patients-with-inflammatory-bowel-disease
#10
Resul Kahraman, Turan Calhan, Abdurrahman Sahin, Kamil Ozdil, Zuhal Caliskan, Elif Sinem Bireller, Bedia Cakmakoglu
This study examined the adiponectin and leptin levels and insulin resistance (IR) in patients with inflammatory bowel disease (IBD) and the associations between these factors and IBD characteristics. Fasting serum leptin, adiponectin, glucose, and insulin levels, as well as inflammatory parameters, were measured in 105 patients with IBD (49 patients with Crohn's disease [CD], 56 patients with ulcerative colitis [UC]) and 98 healthy controls [HC]. IR was evaluated using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29031854/angptl-4-induces-diabetic-retinal-inflammation-by-activating-profilin-1
#11
Qianyi Lu, Peirong Lu, Wei Chen, Li Lu, Zhi Zheng
Diabetic retinopathy (DR), the most common cause of irreversible blindness in working-age adults, results in central vision loss that is caused by microvascular damage to the inner lining of the back of the eye, the retina. The aim of this work was to assess the temporal relationships between angiopoietin-like protein-4 (ANGPTL-4), a novel adipocytokine factor, and diabetic retinal inflammation and microvascular dysfunction. The downstream pathway(s) and upstream mediator(s) of ANGPTL-4 were then determined under high glucose (HG) conditions...
October 13, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29029093/electronegative-low-density-lipoprotein-l5-induces-adipose-tissue-inflammation-associated-with-metabolic-syndrome
#12
Liang-Yin Ke, Hua-Chen Chan, Hsiu-Chuan Chan, Franklin Chikodi Udo Kalu, Hsiang-Chun Lee, I-Ling Lin, Shih-Jie Jhuo, Wen-Ter Lai, Chen-Rong Tsao, Tatsuya Sawamura, Richard A Dixon, Chu-Huang Chen, Chih-Sheng Chu, Shyi-Jang Shin
Context: Electronegative low-density lipoprotein (LDL) L5 is a naturally occurring, atherogenic entity found at elevated levels in the plasma of patients with metabolic syndrome (MetS) in the absence of elevated plasma LDL levels. Objective: To investigate the role of L5 in the mechanism of adipose tissue inflammation associated with MetS. Patients/Setting: Plasma LDL isolated from MetS patients (n=29) and controls (n=29) with similar plasma LDL levels was separated into 5 subfractions, L1-L5, with increasing electronegativity...
September 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29026217/ctrp4-a-new-member-of-the-adipocytokine-family
#13
Lu Wang
No abstract text is available yet for this article.
October 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29020958/does-replacing-sedentary-behaviour-with-light-or-moderate-to-vigorous-physical-activity-modulate-inflammatory-status-in-adults
#14
Catherine M Phillips, Christina B Dillon, Ivan J Perry
BACKGROUND: Sedentary behaviour, obesity and insulin resistance are associated with pro-inflammatory status. Limited data on whether physical activity modulates inflammatory status and counteracts obesity and insulin resistance associated low-grade inflammation exist. Our objective was to investigate associations between objectively measured physical activity and inflammatory status, and specifically whether substituting daily sedentary behaviour with light activity or moderate to vigorous physical activity (MVPA), is associated with beneficial alterations to the inflammatory profile among middle-aged adults and those at increased cardiometabolic risk (obese and insulin resistant subjects)...
October 11, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29017362/association-between-uncoupling-protein-2-adiponectin-and-resting-energy-expenditure-in-obese-women-with-normal-and-low-resting-energy-expenditure
#15
Zahra Taghadomi Masoumi, Mohammad Reza Eshraghian, Mahdi Hedayati, Hamideh Pishva
Obesity is recognized as the most prevalent metabolic disease worldwide. Decreases in energy expenditure may increase risk of obesity. One of the key regulators of energy balance is uncoupling protein2 (UCP2), a transporter protein presents in mitochondrial inner membrane. Moreover, adiponectin is the most abundant adipocytokine, it may play a role in energy metabolism and gene expression of UCP2. The aim of this study was to investigate potential associations between the level of uncoupling protein 2 and adiponectin and their relationship with REE (Resting Energy Expenditure) in obese women with normal and low resting energy expenditure...
October 10, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28987237/effect-of-home-based-exercise-intervention-on-fasting-insulin-and-adipocytokines-in-colorectal-cancer-survivors-a-randomized-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Mi Kyung Lee, Ji-Young Kim, Dong-Il Kim, Dong-Woo Kang, Ji-Hye Park, Ki-Yong Ahn, Hyuk In Yang, Dong Hoon Lee, Yun Ho Roh, Ji-Won Lee, Sang-Hui Chu, Jeffrey A Meyerhardt, Lee W Jones, Nam-Kyu Kim, Justin Y Jeon
BACKGROUND AND AIMS: Elevated circulating insulin is associated with increased risk of recurrence and cancer mortality in early-stage colorectal cancer (CRC). We conducted a randomized controlled trial to determine the effect of a 12-week home-based exercise program on fasting insulin, adipocytokines, and physical function in CRC survivors. METHODS: One hundred and twenty-three stage II-III CRC patients were randomly assigned to either a home-based exercise (n=62) or standard care control group (n=61) for 12weeks...
November 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28982658/cholesterol-and-triglyceride-levels-in-first-episode-psychosis-systematic-review-and-meta-analysis
#17
REVIEW
Toby Pillinger, Katherine Beck, Brendon Stubbs, Oliver D Howes
BackgroundThe extent of metabolic and lipid changes in first-episode psychosis (FEP) is unclear.AimsTo investigate whether individuals with FEP and no or minimal antipsychotic exposure show lipid and adipocytokine abnormalities compared with healthy controls.MethodWe conducted a meta-analysis of studies examining lipid and adipocytokine parameters in individuals with FEP and no or minimal antipsychotic exposure v. a healthy control group. Studies reported fasting total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and leptin levels...
October 5, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28957567/infrapatellar-fat-pad-features-in-osteoarthritis-a-histopathological-and-molecular-study
#18
Marta Favero, Hamza El-Hadi, Elisa Belluzzi, Marnie Granzotto, Andrea Porzionato, Gloria Sarasin, Anna Rambaldo, Claudio Iacobellis, Augusto Cigolotti, Chiara Giulia Fontanella, Arturo Natali, Roberta Ramonda, Pietro Ruggieri, Raffaele De Caro, Roberto Vettor, Marco Rossato, Veronica Macchi
Objective: The infrapatellar fat pad (IFP) is considered a local producer of adipocytokines, suggesting a potential role in OA. The objective of this study was to evaluate the histopathological and molecular characteristics of OA IFPs compared with controls. Methods: The histopathological characteristics of IFPs were evaluated in patients undergoing total knee replacements and in control patients (without OA), considering the following parameters: presence of inflammatory cells, vascularization, adipose lobules dimension and thickness of the interlobular septa...
October 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28955384/exploring-the-crosstalk-between-adipose-tissue-and-the-cardiovascular-system
#19
REVIEW
Ioannis Akoumianakis, Nadia Akawi, Charalambos Antoniades
Obesity is a clinical entity critically involved in the development and progression of cardiovascular disease (CVD), which is characterised by variable expansion of adipose tissue (AT) mass across the body as well as by phenotypic alterations in AT. AT is able to secrete a diverse spectrum of biologically active substances called adipocytokines, which reach the cardiovascular system via both endocrine and paracrine routes, potentially regulating a variety of physiological and pathophysiological responses in the vasculature and heart...
September 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28951766/effect-of-weight-loss-exercise-or-both-on-undercarboxylated-osteocalcin-and-insulin-secretion-in-frail-obese-older-adults
#20
Georgia Colleluori, Nicola Napoli, Uma Phadnis, Reina Armamento-Villareal, Dennis T Villareal
BACKGROUND: Obesity exacerbates age-related decline in glucometabolic control. Undercarboxylated osteocalcin (UcOC) regulates pancreatic insulin secretion. The long-term effect of lifestyle interventions on UcOC and insulin secretion has not been investigated. METHODS: One hundred seven frail, obese older adults were randomized into the control (N = 27), diet (N = 26), exercise (N = 26), and diet-exercise (N = 28) groups for 1 year. Main outcomes included changes in UcOC and disposition index (DI)...
2017: Oxidative Medicine and Cellular Longevity
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