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https://www.readbyqxmd.com/read/29775159/bioinformatics-functional-analysis-of-let-7a-mir-34a-and-mir-199a-b-reveals-novel-insights-into-immune-system-pathways-and-cancer-hallmarks-for-hepatocellular-carcinoma
#1
Bangly Soliman, Ahmed Salem, Mohamed Ghazy, Nourhan Abu-Shahba, Mahmoud El Hefnawi
Let-7a, miR-34a, and miR-199 a/b have gained a great attention as master regulators for cellular processes. In particular, these three micro-RNAs act as potential onco-suppressors for hepatocellular carcinoma. Bioinformatics can reveal the functionality of these micro-RNAs through target prediction and functional annotation analysis. In the current study, in silico analysis using innovative servers (miRror Suite, DAVID, miRGator V3.0, GeneTrail) has demonstrated the combinatorial and the individual target genes of these micro-RNAs and further explored their roles in hepatocellular carcinoma progression...
May 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29769704/effect-of-protocatechuic-acid-on-insulin-responsiveness-and-inflammation-in-visceral-adipose-tissue-from-obese-individuals-possible-role-for-ptp1b
#2
Paulina Ormazabal, Beatrice Scazzocchio, Rosaria Varì, Carmela Santangelo, Massimo D'Archivio, Gianfranco Silecchia, Annunziata Iacovelli, Claudio Giovannini, Roberta Masella
BACKGROUND/OBJECTIVES: The occurrence of chronic inflammation in visceral adipose tissue (VAT) in obese subjects precipitates the development of insulin resistance and type 2 diabetes (T2D). Anthocyanins and their main metabolite protocatechuic acid (PCA) have been demonstrated to stimulate insulin signaling in human adipocytes. The aim of this study was to investigate whether PCA is able to modulate insulin responsiveness and inflammation in VAT from obese (OB) and normal weight (NW) subjects...
May 16, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29740234/associations-of-spexin-and-cardiometabolic-parameters-among-women-with-and-without-gestational-diabetes-mellitus
#3
Nasser M Al-Daghri, Hazim A Al-Hazmi, Abdulrahman Al-Ajlan, Mohammad S Masoud, Abeer Al-Amro, Amani Al-Ghamdi, Abdullah M Alnaami, Omar S Al-Attas, Majed S Alokail
Spexin (SPX) is a novel biomarker abundantly expressed in several animal and human tissues implicated in food intake and glucose control, respectively. As new roles for SPX are emerging, the present study explored for the first time, the associations of SPX to several cardiometabolic indices and inflammatory markers in pregnant women, a demographic not yet investigated with respect to SPX. A total of 117 Saudi women subdivided to those with gestational diabetes mellitus (GDM) (N = 63) and those without (N = 54) were included in this cross-sectional study...
May 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29734265/vaspin-prevents-tumor-necrosis-factor-%C3%AE-induced-apoptosis-in-cardiomyocytes-by-promoting-autophagy
#4
Xuan Ke, Yanqin Hao, Bingong Li, Jin Zou, Xuelian Li, Chunying Wei, Fuyou Liu, Zhiyong Zhang
Visceral adipose tissue-derived serine protease inhibitor (Vaspin) is an adipocytokine that has been shown to exert anti-inflammatory effects and inhibits apoptosis under diabetic conditions. This study was designed to investigate the impact of vaspin on autophagy in tumor necrosis factor (TNF)-α-induced injury in cardiomyocytes and its cardioprotective effects in the pathogenesis of diabetic cardiomyopathy (DCM). H9C2 cells were treated with TNF-α with or without vaspin in vitro. Tumor necrosis factor-α treatment inhibited autophagy and promoted apoptosis in H9C2 cells after stimulating for 24 hours...
May 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29716676/high-prevalence-of-metabolic-syndrome-in-antisynthetase-syndrome
#5
Paula A O Araujo, Marilda Guimarães Silva, Eduardo Ferreira Borba, Samuel K Shinjo
OBJECTIVES: A high frequency of metabolic syndrome (MetS) has been recently described in different idiopathic inflammatory myopathies, but not in antisynthetase syndrome (ASS). Therefore, the aim of the present study was to determine the prevalence of MetS in ASS and also its possible association with cardiovascular the risk factors and ASS-related disease characteristics. METHODS: A cross-sectional single centre study of 42 consecutive ASS patients was conducted from 2012 to 2015 and compared to 84 healthy individuals matched for gender, age, ethnicity and body mass index-matched (control group)...
March 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29708516/increased-prevalence-of-metabolic-syndrome-and-adipocytokine-levels-in-a-psoriatic-arthritis-cohort
#6
Joy Feld, Sarit Nissan, Lihi Eder, Michal Amit Rahat, Muna Elias, Doron Rimar, Arie Laor, Haim Bitterman, Devy Zisman
OBJECTIVE: The aims of this study were to evaluate the prevalence of metabolic syndrome (MetS) in psoriatic arthritis (PsA) patients according to the most recent definition in a Mediterranean population and to determine its association with biomarkers of inflammation and serum adipocytokine levels. METHODS: Demographic, clinical, and laboratory data were collected on 74 patients with PsA and 82 control subjects. The presence of MetS was determined according to the current "harmonization" definition...
February 22, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29687267/muscle-quality-characteristics-of-muscles-in-the-thigh-upper-arm-and-lower-back-in-elderly-men-and-women
#7
Akito Yoshiko, Takashi Kaji, Hiroki Sugiyama, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Akima
PURPOSE: The ratio of fat within skeletal muscle is an important parameter that is indicative of muscle quality, and can be assessed using ultrasonography to measure echo intensity (EI). Muscle EI indicates muscle strength and risk of physical dysfunction; however, this observation was determined following examinations of only selected muscle. The purpose of this study was to investigate the EI characteristics of muscles in several regions in elderly men and women, using physical function tests and serum cholesterol levels...
April 23, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29684222/liver-disease-in-a-residential-cohort-with-elevated-polychlorinated-biphenyl-exposures
#8
Heather B Clair, Christina M Pinkston, Shesh N Rai, Marian Pavuk, Nina D Dutton, Guy Brock, Russell A Prough, K Cameron Falkner, Craig J McClain, Matthew C Cave
Endocrine and metabolism disrupting chemicals (EDCs/MDCs) have been associated with environmental liver diseases including toxicant-associated steatohepatitis (TASH). TASH has previously been characterized by hepatocellular necrosis, disrupted intermediary metabolism, and liver inflammation. Polychlorinated biphenyls (PCBs) are environmental EDCs/MDCs associated with the genesis and progression of steatohepatitis in animal models and human liver injury in epidemiology studies. The cross-sectional Anniston Community Health Survey (ACHS) investigates ortho-substituted PCB exposures and health effects near a former PCB manufacturing complex...
April 19, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29676540/effects-of-omega-3-supplementation-on-adipocytokines-in-prediabetes-and-type-2-diabetes-mellitus-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#9
REVIEW
Tarik Becic, Christian Studenik
BACKGROUND: The objective of this systematic review and meta-analysis was to determine the effects of omega-3 supplementation on adipocytokine levels in adult prediabetic and diabetic individuals. METHODS: We searched PubMed, Medline, EMBASE, Scopus, Web of Science, Google Scholar, Cochrane Trial Register, World Health Organization Clinical Trial Registry Platform, and Clinicaltrial.gov Registry from inception to August 1, 2017 for randomized controlled trials. Pooled effects of interventions were assessed as mean difference using random effects model...
April 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29627363/nesfatin-1-functions-as-a-switch-for-phenotype-transformation-and-proliferation-of-vsmcs-in-hypertensive-vascular-remodeling
#10
Qing-Bo Lu, Hui-Ping Wang, Zi-Han Tang, Han Cheng, Qiong Du, Yuan-Ben Wang, Wu-Bing Feng, Ke-Xue Li, Wei-Wei Cai, Li-Ying Qiu, Hai-Jian Sun
The phenotypic transformation from differentiated to dedifferentiated vascular smooth muscle cells (VSMCs) plays a crucial role in VSMC proliferation and vascular remodeling in many cardiovascular diseases including hypertension. Nesfatin-1, a multifunctional adipocytokine, is critically involved in the regulation of blood pressure. However, it is still largely unexplored whether nesfatin-1 is a potential candidate in VSMC phenotypic switch and proliferation in hypertension. Experiments were carried out in Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR), human VSMCs and primary rat aortic VSMCs...
April 5, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29619269/omentin-1-prevents-inflammation-induced-osteoporosis-by-downregulating-the-pro-inflammatory-cytokines
#11
Shan-Shan Rao, Yin Hu, Ping-Li Xie, Jia Cao, Zhen-Xing Wang, Jiang-Hua Liu, Hao Yin, Jie Huang, Yi-Juan Tan, Juan Luo, Ming-Jie Luo, Si-Yuan Tang, Tuan-Hui Chen, Ling-Qing Yuan, Er-Yuan Liao, Ran Xu, Zheng-Zhao Liu, Chun-Yuan Chen, Hui Xie
Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in the pro-inflammatory cytokines make an important contribution to bone loss by promoting bone resorption and impairing bone formation. Omentin-1 is a newly identified adipocytokine that has anti-inflammatory effects, but little is known about the role of omentin-1 in inflammatory osteoporosis. Here we generated global omentin-1 knockout ( omentin-1 -/- ) mice and demonstrated that depletion of omentin-1 induces inflammatory bone loss-like phenotypes in mice, as defined by abnormally elevated pro-inflammatory cytokines, increased osteoclast formation and bone tissue destruction, as well as impaired osteogenic activities...
2018: Bone Research
https://www.readbyqxmd.com/read/29615317/interleukin-10-as-a-novel-biomarker-of-metabolic-risk-factors
#12
Himani Kulshrestha, Vani Gupta, Smeeksha Mishra, Abbas Ali Mahdi, Shelly Awasthi, Sandeep Chaudhry
BACKGROUND: Interleukin-10 (IL-10) is an adipocytokine that is abundantly expressed in visceral fat tissue. We investigated the association of interleukin-10 with the number of metabolic risk factors. FINDING: The study population comprised 220 children who underwent annual health checkups. Plasma Interleukin-10 levels were determined by enzyme-linked immunosorbent assay. We divided the subjects into 4 groups according to Interleukin-10 levels. A reduction of plasma interleukin-10 levels significantly correlated with an increase in the mean number of metabolic risk factors such as increased waist circumference, BMI, dyslipidaemia, high blood pressure and glucose intolerance...
March 27, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29605673/high-fat-diet-exacerbates-early-psoriatic-skin-inflammation-independent-of-obesity-saturated-fatty-acids-as-key-players
#13
Diana Herbert, Sandra Franz, Yulia Popkova, Ulf Anderegg, Jürgen Schiller, Katharina Schwede, Axel Lorz, Jan C Simon, Anja Saalbach
In obesity, hypertrophic adipocytes secret high amounts of adipocytokines resulting in low-grade inflammation- amplified by infiltrating pro-inflammatory macrophages, oxidative stress, hypoxia and lipolysis. It is known, that these chronic pro-inflammatory conditions support the development of type II diabetes and cardio vascular diseases, while mechanisms of obesity-related exacerbation of inflammatory skin disorders like psoriasis are unclear. In this study, we uncover nutritional saturated fatty acids (SFAs) as major risk factors for the amplification of skin inflammation, independent of obesity-related parameters, like fat mass extension, adipocytokines and glucose homeostasis...
March 29, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29567249/mulberry-leaf-extracts-prevent-obesity-induced-nafld-with-regulating-adipocytokines-inflammation-and-oxidative-stress
#14
Chiung-Huei Peng, Huei-Ting Lin, Dai-Jung Chung, Chien-Ning Huang, Chau-Jong Wang
Mulberry (Morus alba) leaf has been used in Chinese medicine as the remedy for hyperlipidemia and metabolic disorders. Recent report indicated Mulberry leaf extract (MLE) attenuated dyslipidemia and lipid accumulation in high fat diet (HFD)-fed mice. Non-alcoholic fatty liver (NAFLD) is generally considered as the liver component of metabolic syndrome. The hepatic lipid infiltration induces oxidative stress, and is associated with interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) which are regulated by the leptin and adiponectin...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29566716/overexpression-of-zinc-%C3%AE-2-glycoprotein-suppressed-seizures-and-seizure-related-neuroflammation-in-pentylenetetrazol-kindled-rats
#15
Ying Liu, Teng Wang, Xi Liu, Yuetao Wen, Tao Xu, Xinyuan Yu, Xin Wei, Xueying Ding, Lijuan Mo, Maojia Yin, Xinjie Tan, Lifen Chen
BACKGROUND: Zinc-α2-glycoprotein (ZAG) is a 42-kDa protein reported as an anti-inflammatory adipocytokine. Evidences from clinical and experimental studies revealed that brain inflammation plays important roles in epileptogenesis and seizure. Interestingly, closely relationship between ZAG and many important inflammatory mediators has been proven. Our previous study identified ZAG in neurons and found that ZAG is decreased in epilepsy and interacts with TGFβ and ERK. This study aimed to investigate the role of ZAG in seizure and explore its effect on seizure-related neuroinflammation...
March 22, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29563042/exploring-differentially-expressed-genes-related-to-metabolism-by-rna-seq-in-goat-liver-after-dexamethasone-treatment
#16
Qu Chen, Canfeng Hua, Liqiong Niu, Yali Geng, Liuping Cai, Shiyu Tao, Yingdong Ni, Ruqian Zhao
Chronic stress severely threatens the welfare and health of animals and humans. In order to study the effects of chronic stress on metabolism, de novo transcriptome sequencing was used to generate the expressed sequence tag dataset for the goat, using nextgeneration sequencing technology. For this study, consecutive dexamethasone (Dex) injection was used in 10 healthy male goats (body weight 25 ± 1.0 kg) to mimic chronic stress. Ten male goats were randomly assigned into two groups, one group was injected intramuscularly with the same volume of saline as control (Con) group, and another (Dex) group was injected intramuscularly with 0...
March 18, 2018: Gene
https://www.readbyqxmd.com/read/29549722/serum-levels-of-selected-adipocytokines-in-benign-and-malignant-parotid-gland-tumor-patients
#17
Pawel Sowa, Maciej Misiolek, Boguslawa Orecka, Eugeniusz Czecior, Monika Adamczyk-Sowa
OBJECTIVES: The aim of this study was to evaluate serum levels of adiponectin, leptin, visfatin and IL-6 in patients with pleomorphic adenoma, Warthin's tumor and acinic cell carcinoma of the parotid gland. MATERIALS AND METHODS: Venous blood samples were collected from 30 patients with pleomorphic adenoma, 21 patients with Warthin's tumor and 8 patients with acinic cell carcinoma. Serum adiponectin, leptin, visfatin, IL-6 and CRP concentrations were determined...
June 2018: Cytokine
https://www.readbyqxmd.com/read/29548578/impact-of-regular-physical-activity-on-adipocytokines-and-cardiovascular-characteristics-in-spinal-cord-injured-subjects
#18
Roberto Schreiber, Cristiane M Souza, Layde R Paim, Guilherme de Rossi, José R Matos-Souza, Anselmo de A Costa E Silva, Fernando R Faria, Eliza R Azevedo, Karina C Alonso, Andrei C Sposito, Alberto Cliquet, José I Gorla, Wilson Nadruz
OBJECTIVE: To investigate the relationship of carotid artery intima-media thickness (IMT) and cardiac structure and function with adipocytokines in sedentary (S-SCI) and physically active (PA-SCI) subjects with spinal cord injury (SCI). DESIGN: Cross-sectional observational study. SETTING: Academic medical center. PARTICIPANTS: Men with chronic (>1y) SCI (N=41; 16 S-SCI, 25 PA-SCI) were evaluated. S-SCI subjects did not perform labor that required physical effort, recreational physical activity, or sports, while PA-SCI subjects included competing athletes who were regularly performing adapted sports...
March 13, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29545541/toosendanin-inhibits-adipogenesis-by-activating-wnt-%C3%AE-catenin-signaling
#19
Tian-Xing Chen, Xiao-Ying Cheng, Yun Wang, Wu Yin
Toosendanin (TSN), a triterpenoid extracted from Melia toosendan, has been reported to possess anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. However, its anti-adipogenic effect remains unknown. Here, we found that TSN dose-dependently attenuated lipid accumulation in preadipocytes 3T3-L1 as evidenced by Oil Red O staining. TSN also significantly downregulated mRNA and protein levels of adipocytokines (adiponectin and leptin), CCAAT/enhancer binding proteins α (C/EBP-α), peroxisome proliferator-activated receptor γ (PPAR-γ), fatty acid synthase, and acetyl-CoA carboxylase in adipocytes...
March 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29535934/prevalence-rates-of-adipoq-polymorphisms-in-indian-population-and-a-comparison-with-other-populations
#20
Sandhya Kiran Pemmasani, Rasika Raman, Anuradha Acharya
Introduction: The adiponectin gene, ADIPOQ , encodes an adipocytokine, known as adiponectin hormone. This hormone is known to be associated with insulin sensitization, fat metabolism, immunity, and inflammatory response. Polymorphisms in ADIPOQ gene lower the adiponectin levels, increasing the risk for diabetes and cardiovascular diseases. Aims: The study aimed to calculate the prevalence rates of ADIPOQ polymorphisms in Indian population and to compare those prevalence rates with that of other populations...
January 2018: Indian Journal of Endocrinology and Metabolism
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