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Adipocytokines

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https://www.readbyqxmd.com/read/28339344/correlation-of-leptin-adiponectin-and-resistin-levels-in-different-types-of-lipodystrophy-in-hiv-aids-patients
#1
Danica Srdic, Al Musalhi Khawla, Ivan Soldatovic, Jelena Nikolic, Djordje Jevtovic, Devaki Nair, Gordana Dragovic
BACKGROUND: Leptin, adiponectin, and resistin may play an important role in the development of lipodystrophy (LD) in HIV/AIDS patients. The aim of this study was to correlate levels of leptin, adiponectin, and resistin between HIV/AIDS patients with LD and without lipodystrophy (non-LD), as well as between subgroups of LD [lipoatrophy (LA), lipohypertrophy (LH), and mixed fat redistribution (MFR)] and non-LD patients. METHODS: Cross-sectional study of 66 HIV/AIDS patients...
April 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28325076/omentin-val109asp-polymorphism-and-risk-of-coronary-artery-disease
#2
Javad Jamshidi, Mehrdad Ghanbari, Ali Asnaashari, Nosaybeh Jafari, Gholam Abbas Valizadeh
Background Omentin is an adipocytokine with antiinflammatory properties. It has been reported to be involved in atherosclerosis and coronary artery disease. We aimed to investigate the association of omentin Val109Asp polymorphism with coronary artery disease in an Iranian population. Methods For a case-control study, 400 individuals were recruited: 200 with coronary artery disease and 200 healthy controls. Patients with coronary artery disease were diagnosed by angiography as having at least one main coronary artery with more than 50% stenosis...
March 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28320046/increased-insulin-resistance-and-glucagon-levels-in-mild-inactive-systemic-lupus-patients-despite-normal-glucose-tolerance
#3
Cíntia Nh Miyake, Bruno Gualano, Wagner S Dantas, Renato T Pereira, William Neves, Vanessa O Zambelli, Samuel K Shinjo, Rosa M Pereira, Elizabeth R Silva, Ana Lúcia Sá-Pinto, Eduardo Borba, Hamilton Roschel, Eloisa Bonfá, Fabiana B Benatti
OBJECTIVE: To assess insulin sensitivity in patients with systemic lupus erythematosus (SLE) in response to a meal tolerance test (MTT). METHODS: In this cross-sectional study, 33 adult females mild/inactive SLE and 16 age- and body mass index (BMI)-matched female healthy controls (CTRL) underwent a MTT and were assessed for insulin sensitivity and beta-cell function. Skeletal muscle protein expressions of total and membrane GLUT-4 were also evaluated (SLE, n=10; CTRL, n=5); muscle biopsies were performed after MTT...
March 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28315198/erratum-to-the-role-of-adipocytokines-in-coronary-atherosclerosis
#4
Luca Liberale, Aldo Bonaventura, Alessandra Vecchiè, Matteo Casula, Franco Dallegri, Fabrizio Montecucco, Federico Carbone
No abstract text is available yet for this article.
May 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28302957/relationship-between-asymmetric-dimethylarginine-in-umbilical-cord-plasma-and-birth-weight-follows-a-u-shaped-curve
#5
Junji Takaya, Yuko Tanabe, Yuichi Kuroyanagi, Kazunari Kaneko
Asymmetric dimethylarginine (ADMA) is a nonselective nitric oxide (NO) synthase inhibitor associated with cardiovascular and metabolic disorders. NO regulates placental blood flow, which plays an important role in fetal growth. Many epidemiological studies have disclosed that restricted fetal growth is associated with an increased risk of insulin resistance in adult life. We studied the relationship between ADMA in cord blood and birth size. Nine small for gestational age (SGA) and 32 appropriate for gestational age (AGA) infants were studied...
March 7, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28292381/serum-levels-of-visfatin-and-interleukin-6-in-non-obese-versus-obese-men-with-coronary-artery-disease
#6
Shaheena Naz, Qamar Shakoor Sandhu, Abida Akhtar, Uzma Zafar, Attiqa Khalid, Muniza Saeed
OBJECTIVE: To evaluate and compare the serum levels of visfatin, interleukin-6 and lipid profile in non-obese and obese male patients with coronary artery disease. STUDY DESIGN: Observational, comparative study. PLACE AND DURATION OF STUDY: Punjab Institute of Cardiology and Lahore General Hospital, Lahore, from July to December 2013. METHODOLOGY: The participants included 20 non-obese group I with coronary artery disease (CAD) and 20 obese males group II with coronary artery disease (angiographically confirmed)...
February 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28288470/circulating-concentrations-of-adipocytokines-and-their-receptors-in-the-isolated-corpus-cavernosum-and-femoral-artery-from-trained-rats-on-a-high-fat-diet
#7
Amanda C S Sponton, Fábio H Silva, Hygor N Araujo, Carmem P Valgas da Silva, Camila de Moraes, Edson Antunes, Angelina Zanesco, Maria A Delbin
BACKGROUND: The aim of the present study was to evaluate different signaling pathways by which exercise training would interfere in endothelial function in obesity. Therefore, we examined adipocytokine levels and their receptors in the corpus cavernosum and femoral artery from trained rats on a high-fat diet. METHODS: Functional experiments were performed in control sedentary and trained rats, and sedentary (h-SD) and trained male Wistar rats on a high-fat diet (h-TR)...
March 14, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28287842/the-correlation-between-insulin-like-growth-factor-1-igf-1-and-novel-adipocytokines-in-postmenopausal-women-a-population-based-study
#8
Hossein Darabi, Afshin Ostovar, Alireza Raeisi, Mohammad Reza Kalantarhormozi, Majid Assadi, Samad Akbarzadeh, Safieh Momeni, Sina Dobaradaran, Katayoun Vahdat, Iraj Nabipour
The adipocytokines and insulin-like growth factor 1 (IGF-1) are involved in insulin resistance, the cardiometabolic syndrome, and atherosclerosis. Therefore, investigating the relationship between circulating levels of the novel adipocytokines and IGF-1 is worthwhile. The correlation between IGF-1, visfatin, and omentin-1 has not been adequately investigated. In a population-based study, 324 postmenopausal women were randomly selected. Circulating IGF-1, visfatin, omentin-1, adiponectin, and high-sensitivity C-reactive protein (hs-CRP) levels were measured with the highly specific enzyme-linked immunosorbent assay method...
March 13, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28277301/body-composition-analysis-and-adipocytokine-concentrations-in-haemodialysis-patients-abdominal-fat-gain-as-an-added-cardiovascular-risk-factor-abdominal-fat-gain-and-cardiovascular-risk
#9
Elena González, Juan J Díez, Almudena Pérez Torres, María Auxiliadora Bajo, Gloria Del Peso, Rafael Sánchez-Villanueva, Cristina Grande, Olaia Rodríguez, Mónica Coronado, Carmen Gómez Candela, Mariana Díaz-Almirón, Pedro Iglesias, Rafael Selgas
INTRODUCTION: Abdominal fat and its increment over time in particular has become a cardiovascular risk factor in uraemic patients. OBJECTIVES: To analyse changes in abdominal fat in haemodialysis patients over one year and study their possible correlation with the variation in adipocytokine serum levels. As a secondary objective, we tried to validate the data obtained by bioelectrical impedance analysis (BIA) with data obtained by dual X-ray absorptiometry (DXA)...
October 26, 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28270183/the-link-between-obesity-and-migraine-in-childhood-a-systematic-review
#10
REVIEW
G Farello, P Ferrara, A Antenucci, C Basti, A Verrotti
Obesity and headache are two highly prevalent diseases both in adults and children and they are associated with a strong personal and social impact. Many studies suggest that obesity is comorbid with headache in general, and migraine in particular and obesity seems to be a risk factor for migraine progression and for migraine frequency both in adults and in children. Research shows that there are multiple areas of overlap between migraine pathophysiology and the central and peripheral pathways regulating feeding: inflammatory mediators such as the calcitonin gene-related protein (CGRP), neurotransmitters such as serotonin, peptides such as orexin and adipocytokines such as adiponectin (ADP) and leptin could explain the common pathogenesis...
March 7, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28266659/sequential-activation-of-different-pathway-networks-in-ischemia-affected-and-non-affected-myocardium-inducing-intrinsic-remote-conditioning-to-prevent-left-ventricular-remodeling
#11
Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, Abelina Zimba, David Lorant, Georg Goliasch, Johannes Winkler, Dietmar Pils, Katharina Auer, Hendrik Jan Ankersmit, Zoltán Giricz, Tamas Baranyai, Márta Sárközy, András Jakab, Rita Garamvölgyi, Maximilian Y Emmert, Simon P Hoerstrup, Derek J Hausenloy, Péter Ferdinandy, Gerald Maurer, Mariann Gyöngyösi
We have analyzed the pathway networks of ischemia-affected and remote myocardial areas after repetitive ischemia/reperfusion (r-I/R) injury without ensuing myocardial infarction (MI) to elaborate a spatial- and chronologic model of cardioprotective gene networks to prevent left ventricular (LV) adverse remodeling. Domestic pigs underwent three cycles of 10/10 min r-I/R by percutaneous intracoronary balloon inflation/deflation in the mid left anterior descending artery, without consecutive MI. Sham interventions (n = 8) served as controls...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28264477/a-systematic-study-of-dysregulated-microrna-in-type-2-diabetes-mellitus
#12
Yuqing He, Yuanlin Ding, Biyu Liang, Juanjuan Lin, Taek-Kyun Kim, Haibing Yu, Hanwei Hang, Kai Wang
MicroRNAs (miRNAs) are small noncoding RNAs that modulate the cellular transcriptome at the post-transcriptional level. miRNA plays important roles in different disease manifestation, including type 2 diabetes mellitus (T2DM). Many studies have characterized the changes of miRNAs in T2DM, a complex systematic disease; however, few studies have integrated these findings and explored the functional effects of the dysregulated miRNAs identified. To investigate the involvement of miRNAs in T2DM, we obtained and analyzed all relevant studies published prior to 18 October 2016 from various literature databases...
February 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28263744/gpr120-in-adipocytes-has-differential-roles-in-the-production-of-pro-inflammatory-adipocytokines
#13
Arif Ul Hasan, Koji Ohmori, Takeshi Hashimoto, Kazuyo Kamitori, Fuminori Yamaguchi, Takahisa Noma, Junsuke Igarashi, Kazuhito Tsuboi, Masaaki Tokuda, Akira Nishiyama, Masakazu Kohno
How nutritional excess leads to inflammatory responses in metabolic syndrome is not well characterized. Here, we evaluated the effects of ω-3 polyunsaturated fatty acid specific G-protein coupled receptor 120 (GPR120) activation on inflammatory pathways in adipocytes, and the influence of this process on macrophage migration. Using 3T3-L1 adipocytes, we found that agonizing GPR120 using its synthetic ligand, GSK137647, attenuated both basal and lipopolysaccharide-induced production of interleukin-6 (IL-6) and C-C motif chemokine ligand 2 (CCL2)...
March 3, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28260062/serum-microrna-profiling-and-bioinformatics-analysis-of-patients-with-type-2-diabetes-mellitus-in-a-chinese-population
#14
Ze-Min Yang, Long-Hui Chen, Min Hong, Ying-Yu Chen, Xiao-Rong Yang, Si-Meng Tang, Qian-Fa Yuan, Wei-Wen Chen
Type 2 diabetes mellitus (T2DM) is characterized by islet β-cell dysfunction and insulin resistance, which leads to an inability to maintain blood glucose homeostasis. Circulating microRNAs (miRNAs) have been suggested as novel biomarkers for T2DM prediction or disease progression. However, miRNAs and their roles in the pathogenesis of T2DM remain to be fully elucidated. In the present study, the serum miRNA expression profiles of T2DM patients in Chinese cohorts were examined. Total RNA was extracted from serum samples of 10 patients with T2DM and five healthy controls, and these was used in reverse-transcription‑quantitative polymerase chain reaction analysis with the Exiqon PCR system of 384 serum/plasma miRNAs...
February 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28259947/methotrexate-improves-perivascular-adipose-tissue-endothelial-dysfunction-via-activation-of-ampk-enos-pathway
#15
Yanmin Ma, Li Li, Yating Shao, Xiaohong Bai, Tiao Bai, Xinliang Huang
Adipose and endothelial dysfunction is associated with cardiovascular disease. Perivascular adipose tissue (PVAT) directly surrounds vessels and influences vessel function via a paracrine effect, and adenosine monophosphate (AMP)-activated protein kinase (AMPK) modulates the metabolic pathway, thus, the present study hypothesized that activation of AMPK in PVAT may regulate endothelial function in pathological settings. The present study investigated the effect of methotrexate (MTX) on adipocytokine expression in PVAT with an emphasis on the regulation of endothelial function...
February 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28258671/the-role-of-chemerin-in-human-disease
#16
Magdalena Stojek
Adipose tissue is not merely a storage depot of triacylglycerols but also a major endocrine organ. Its cells, including adipocytes, synthesize and secrete a range of biologically active molecules termed adipokines. Adipokines that display the properties of cytokines are often called adipocytokines. In recent years there has been increasing interest in a new adipokine called chemerin. Chemerin is a protein synthesized mostly by the adipose tissue and the liver as inactive pre‑pro‑chemerin. After the intracellular hydrolytic cutting off of the 20‑amino‑acid N‑terminal polypeptide, it is secreted into the bloodstream as inactive pro‑chemerin...
February 15, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28256512/transcriptome-based-repurposing-of-apigenin-as-a-potential-anti-fibrotic-agent-targeting-hepatic-stellate-cells
#17
Daniel F Hicks, Nicolas Goossens, Ana Blas-García, Takuma Tsuchida, Benjamin Wooden, Michael C Wallace, Natalia Nieto, Abigale Lade, Benjamin Redhead, Arthur I Cederbaum, Joel T Dudley, Bryan C Fuchs, Youngmin A Lee, Yujin Hoshida, Scott L Friedman
We have used a computational approach to identify anti-fibrotic therapies by querying a transcriptome. A transcriptome signature of activated hepatic stellate cells (HSCs), the primary collagen-secreting cell in liver, and queried against a transcriptomic database that quantifies changes in gene expression in response to 1,309 FDA-approved drugs and bioactives (CMap). The flavonoid apigenin was among 9 top-ranked compounds predicted to have anti-fibrotic activity; indeed, apigenin dose-dependently reduced collagen I in the human HSC line, TWNT-4...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28255215/inflammatory-and-metabolic-syndrome-biomarker-analysis-of-vascular-outcomes-in-end-stage-renal-disease
#18
Patrick J Sweigert, Vinod K Bansal, Debra A Hoppensteadt, Jennifer L Saluk, Daneyal A Syed, Jawed Fareed
End-stage renal disease (ESRD) presents a complex syndrome in which inflammatory and metabolic processes contribute to disease progression and development of comorbid conditions. Over $1 trillion is spent globally on ESRD care. Plasma samples collected from 83 ESRD patients prior to hemodialysis were profiled for metabolic and inflammatory biomarker concentrations. Concentrations were compared between groups with and without history of stroke, acute coronary syndrome (ACS), congestive heart failure (CHF), and coronary artery disease (CAD)...
March 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28239164/adipocyte-c1qtnf5-expression-is-bmi-dependently-related-to-early-adipose-tissue-dysfunction-and-systemic-ctrp5-serum-levels-in-obese-children
#19
J T Schwartze, K Landgraf, U Spielau, D Rockstroh, D Löffler, J Kratzsch, W Kiess, A Körner
BACKGROUND/OBJECTIVES: The recently identified adipocytokine C1QTNF5 (encodes for CTRP5) has been demonstrated to inhibit pro-metabolic insulin signaling in adipocytes. We hypothesized that adipocyte C1QTNF5 expression in subcutaneous (sc) adipose tissue (AT) would correlate with the degree of obesity, systemic CTRP5 serum levels, and early AT and metabolic dysfunction in children. SUBJECTS/METHODS: Sc AT samples were obtained from 33 healthy Caucasian lean children aged 10...
February 27, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28221366/pathway-wide-association-study-identifies-five-shared-pathways-associated-with-schizophrenia-in-three-ancestral-distinct-populations
#20
C Liu, C A Bousman, C Pantelis, E Skafidas, D Zhang, W Yue, I P Everall
Genome-wide association studies have confirmed the polygenic nature of schizophrenia and suggest that there are hundreds or thousands of alleles associated with increased liability for the disorder. However, the generalizability of any one allelic marker of liability is remarkably low and has bred the notion that schizophrenia may be better conceptualized as a pathway(s) disorder. Here, we empirically tested this notion by conducting a pathway-wide association study (PWAS) encompassing 255 experimentally validated Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways among 5033 individuals diagnosed with schizophrenia and 5332 unrelated healthy controls across three distinct ethnic populations; European-American (EA), African-American (AA) and Han Chinese (CH)...
February 21, 2017: Translational Psychiatry
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