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JOURNAL ARTICLE
Kimberly Voon, Bronwyn G A Stuckey
SUMMARY: With rising rates of adoption and surrogacy, induced lactation is likely to become increasingly relevant, allowing women who did not undergo pregnancy to breastfeed. We describe the case of a woman with complete androgen insensitivity syndrome (CAIS) on conventional oestrogen therapy who was expecting a child via surrogacy and who wished to breastfeed. The woman was commenced on supplementary oestrogen therapy, domperidone and breast stimulation by mechanical breast pump 8 weeks prior to the delivery of her child...
October 1, 2023: Endocrinology, Diabetes & Metabolism Case Reports
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JOURNAL ARTICLE
Ahmet Turan Isik, Derya Kaya, Mehmet Selman Ontan, Feyza Mutlay, Esra Ates Bulut, Fatma Sena Dost, Neziha Erken, Ali Ekrem Aydin
OBJECTIVES: Neuroleptic malignant syndrome (NMS) is a life-threatening condition that occurs as an adverse reaction to antipsychotic and antiemetic agents or sudden withdrawal of dopaminergic medications. Given the metabolic and functional reserves and the comorbidities in older adults, NMS may show an atypical course. METHODS: The medical records of patients with neurodegenerative diseases leading to dementia between 2013 and 2020 were reviewed for the diagnosis of NMS...
November 2023: Clinical Neuropharmacology
#23
JOURNAL ARTICLE
Grace McKenzie McBride, Alice R Rumbold, Amy K Keir, Aline Kunnel, Michael Buxton, Susanne Jones, Laura Summers, Michael Stark, Luke E Grzeskowiak
OBJECTIVE: This study aims: (a) to evaluate patterns of domperidone dispensing to mothers of very preterm (<32 weeks gestation) infants born before and after 2014 when international recommendations were made to limit its use and (b) to examine characteristics associated with domperidone dispensing and impacts on breast milk feeding rates at infant hospital discharge. DESIGN: Retrospective audit using linked electronic medical records and hospital pharmacy records...
November 2023: BMJ Paediatrics Open
#24
JOURNAL ARTICLE
Daniela Delgado, Lisa Stellwagen, Sydney McCune, Kristija Sejane, Lars Bode
Background: A growing number of diverse familial structures wish to colactate their infant. For transgender and gender diverse (TGD) individuals, chestfeeding or breastfeeding may be within their goals of parenthood. There is limited evidence on how to induce lactation for a nongestational parent on gender affirming estrogen treatment. Case Presentation: We report the case of a transgender woman who successfully underwent lactation induction following a protocol using the galactogue domperidone plus use of a breast pump...
November 2023: Breastfeeding Medicine
#25
JOURNAL ARTICLE
Qingqing Qi, Nana Wang, Han Liu, Yanqing Li
BACKGROUND: Since the previous network meta-analysis assessing the efficacy of prokinetics for functional dyspepsia (FD), there have been a number of new studies and cinitapride is a new prokinetic agent for FD. This updated meta-analysis aimed to explore the efficacy and safety of prokinetics for FD. METHODS: An updated study search in Pubmed, EMBASE, Cochrane Library and Web of Science was conducted in literatures published from July 2015 to March 2023. Randomized controlled trials investigating the use of prokinetics in adult FD patients were included...
October 31, 2023: BMC Gastroenterology
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RANDOMIZED CONTROLLED TRIAL
Xiu Cai Fang, Zhi Hui Lin, Yong Dong Wu, De An Tian, Shi Liu, Dong Sheng Wu, Han Lin, Fan Dong Meng, Mei Liu, Fan Du, Hui Jun Shu, Zhi Feng Wang, Jian Min Zhuo, Ping Wang, Meng Yu Li, Jian Xu
OBJECTIVE: This pilot study aimed to evaluate the efficacy and safety of domperidone for the treatment of Chinese patients with functional dyspepsia (FD) who were diagnosed according to the Rome IV criteria and to identify the FD subtypes that potentially responded better to domperidone. METHODS: This multicenter prospective study was conducted in China from August 2018 to July 2020, consisting of a 1-week screening phase and a 2-week double-blind treatment phase...
November 2023: Journal of Digestive Diseases
#27
JOURNAL ARTICLE
Rajina Shakya, Mi Ran Byun, Sang Hoon Joo, Kyung-Soo Chun, Joon-Seok Choi
The lack of molecular targets hampers the treatment of triple-negative breast cancer (TNBC). In this study, we determined the cytotoxicity of domperidone, a dopamine D2 receptor (DRD2) antagonist in human TNBC BT-549 and CAL-51 cells. Domperidone inhibited cell growth in a dose- and time-dependent manner. The annexin V/propidium iodide staining showed that domperidone induced apoptosis. The domperidone-induced apoptosis was accompanied by the generation of mitochondrial superoxide and the down-regulation of cyclins and CDKs...
November 1, 2023: Biomolecules & Therapeutics
#28
JOURNAL ARTICLE
Mehedi Hasan Bappi, Abdullah Al Shamsh Prottay, Khattab Al-Khafaji, Md Showkoth Akbor, Muhammad Kamal Hossain, Md Shahazul Islam, Afia Ibnath Asha, Cassio Rocha Medeiros, Catarina Martins Tahim, Elaine Cristina Pereira Lucetti, Henrique Douglas Melo Coutinho, Hossam Kamli, Muhammad Torequl Islam
BACKGROUND: Emesis is a complex physiological phenomenon that serves as a defense against numerous toxins, stressful situations, adverse medication responses, chemotherapy, and movement. Nevertheless, preventing emesis during chemotherapy or other situations is a significant issue for researchers. Hence, the majority view contends that successfully combining therapy is the best course of action. In-vivo analysis offers a more comprehensive grasp of how compounds behave within a complex biological environment, whereas in-silico evaluation refers to the use of computational models to forecast biological interactions...
October 18, 2023: Food and Chemical Toxicology
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JOURNAL ARTICLE
Alejandro Rabanal Basalo, Mercedes Navarro Pablos, Nuria Viejo Pinero, María Luz Vila Méndez, Verónica Molina Barcena, Aránzazu Montilla Bernabé, María Del Pilar Villanueva Morán, Ana María Blanco Gallego, Carmen Guirao Sánchez, Salvador Juárez Antón, Ángela Fernández Rodríguez, María Luisa Revuelta Puigdollers, María Teresa Sarriá Sánchez, Carmen Martín Alegre, Miguel Ángel Martínez Álvarez, María Mestre de Juan, Rebeca Mielgo Salvador, María Teresa Gijón Seco, José Manuel Saníger Herrera, María Esther Rodríguez Jiménez, Begoña Navas de la Peña, Javier Santa Cruz Hernández, Ana María Abad Esteban, Rebeca Díaz Martín, Laura García Pérez, Paloma Herrero Vanrell, María Isabel Arias de Saavedra Criado, Alexandra Vaquero Vinent, Verónica López Gómez, Víctor Manuel Montegrifo Rentero, Lucía Simón Miguel, Ignacio Campo Martos, Silvia Ortiz Zamorano, María Jesús Izquierdo Zamarriego, Izíar Vázquez Carrión, Rosa María López Valero, Carmen Gil, Ana Martínez, Begoña Soler López
INTRODUCTION: The clinical effect of domperidone against COVID-19 has been investigated in a double-blind phase III clinical trial (EudraCT number 2021-001228-17). Domperidone has shown in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and potential immudolatory properties through the stimulation of prolactin secretion. PATIENTS AND METHODS: The efficacy of oral domperidone plus standard of care (SOC; n = 87) versus placebo plus SOC ( n = 86) was evaluated in a 28-day randomized double-blind multicentre study in primary health care centres...
2023: Annals of Medicine
#30
JOURNAL ARTICLE
Maddison Reed, Wen Pan, Lina Musa, Stefania Arlotta, Jan A Mennigen, Michael G Jonz
Dopamine is a neurotransmitter involved in oxygen sensing and control of reflex hyperventilation. In aquatic vertebrates, oxygen sensing occurs in the gills via chemoreceptive neuroepithelial cells (NECs), but a mechanism for dopamine in autonomic control of ventilation has not been defined. We used immunohistochemistry and confocal microscopy to map the distribution of tyrosine hydroxylase (TH), an enzyme necessary for dopamine synthesis, in the gills of zebrafish. TH was found in nerve fibers of the gill filaments and respiratory lamellae...
October 14, 2023: Journal of Comparative Neurology
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JOURNAL ARTICLE
Chonticha Amornrojvaravut, Jomjai Peerapattana
Two key properties of excipients for inclusion in direct compression tablets are flowability and compactibility. Glutinous rice starch (GRS) has poor flowability, which limits its use in direct compression tablets. This study aimed to create a multifunctional direct compression excipient (filler binder disintegrant) with improved flowability from GRS by the co-precipitation method. The physicochemical and pharmaceutical properties of the co-precipitated GRS (cpGRS) were investigated. The optimum conditions for producing cpGRS (0...
September 2023: Heliyon
#32
RANDOMIZED CONTROLLED TRIAL
Karuna Ew Vendrik, Vlada O Chernova, Ed J Kuijper, Elisabeth M Terveer, Jacobus J van Hilten, Maria Fiorella Contarino
INTRODUCTION: Experimental studies suggest a role of gut microbiota in the pathophysiology of Parkinson's disease (PD) via the gut-brain axis. The gut microbiota can also influence the metabolism of levodopa, which is the mainstay of treatment of PD. Therefore, modifying the gut microbiota by faecal microbiota transplantation (FMT) could be a supportive treatment strategy. METHODS AND ANALYSIS: We have developed a study protocol for a single-centre, prospective, self-controlled, interventional, safety and feasibility donor-FMT pilot study with randomisation and double-blinded allocation of donor faeces...
October 5, 2023: BMJ Open
#33
MULTICENTER STUDY
Marta Baxarias, Giulia Donato, Cristina Mateu, Marta Salichs, Josep Homedes, Guadalupe Miró, Maria Grazia Pennisi, Laia Solano-Gallego
BACKGROUND: Domperidone (Leisguard® ) is an immunomodulatory drug used as a preventive measure in healthy dogs. However, no studies have been published in healthy Leishmania infantum-seropositive dogs. The aim of this study was to evaluate the clinical efficacy and safety of domperidone as immunotherapy in Leishmania-seropositive healthy dogs. METHODS: Sixty-seven dogs were treated with domperidone at 0.5 mg/kg and 44 dogs received placebo, once daily for 4 consecutive weeks...
October 4, 2023: Parasites & Vectors
#34
JOURNAL ARTICLE
Ahmet Turan Isik, Derya Kaya, Mehmet Selman Ontan, Feyza Mutlay, Esra Ates Bulut, Fatma Sena Dost, Neziha Erken, Ali Ekrem Aydin
OBJECTIVES: Neuroleptic malignant syndrome (NMS) is a life-threatening condition that occurs as an adverse reaction to antipsychotic and antiemetic agents or sudden withdrawal of dopaminergic medications. Given the metabolic and functional reserves and the comorbidities in older adults, NMS may show an atypical course. METHODS: The medical records of patients with neurodegenerative diseases leading to dementia between 2013 and 2020 were reviewed for the diagnosis of NMS...
September 19, 2023: Clinical Neuropharmacology
#35
JOURNAL ARTICLE
Kitti Krungkraipetch, Chuleekorn Kwanchainon
Plook-Fire-Thatu is a traditional Thai medication designed to assist breastfeeding moms. However, no documented clinical research on its efficacy exists. Therefore, the authors recruited women who had a singleton baby vaginally between June 2019 and July 2020 and randomly allocated them to one of three groups: Plook-Fire-Thatu, Domperidone, or Placebo. The test-weight method was used to compare breastmilk amounts. During the hospital stay, all volunteers and newborns were followed for adverse effects. There were three groups of participants: Plook-Fire-Thatu 78, Domperidone 74, and Placebo 76...
July 2023: African Journal of Reproductive Health
#36
JOURNAL ARTICLE
Francesco Di Mario, Pellegrino Crafa, Lorella Franzoni, Antonio Tursi, Giovanni Brandimarte, Michele Russo, Kryssia Isabel Rodriguez-Castro, Marilisa Franceschi, Nicola De Bortoli, Edoardo Savarino
BACKGROUND: Proton pump inhibitors (PPIs) are currently the reference drugs for gastroesophageal reflux disease (GERD), but symptoms often recur after their withdrawal. Moreover, whether prokinetics or barrier drugs used alongside PPIs are more effective remains under debate. OBJECTIVES: The aim of the study was to assess the efficacy of different therapeutic approaches to GERD treatment. MATERIAL AND METHODS: We enrolled 211 grade A reflux esophagitis patients who consented to participate in this non-randomized, open-label trial...
September 4, 2023: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
#37
JOURNAL ARTICLE
Chingching Foocharoen, Pritaporn Kingkaew, Yot Teerawattananon, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Witsarut Manasirisuk, Jitjira Chaiyarit, Apichat Sangchan
BACKGROUND: Systemic sclerosis (SSc) patients often become refractory to proton pump inhibitors (PPI)-a standard treatment for gastroesophageal reflux disease (GERD)-and intolerant to PPI in combination with domperidone. PPI with alginic acid is an alternative treatment option, but alginic acid is costly. OBJECTIVES: We compared the costs and effectiveness of alginic acid plus PPI versus standard treatments (PPI with/without antacids as needed and lifestyle modifications) for GERD in SSc patients unsuitable for, or intolerant to, domperidone...
September 4, 2023: International Journal of Rheumatic Diseases
#38
JOURNAL ARTICLE
Piriya Chonsut, Palika Wetchakul, Jomkarn Naphatthalung, Chuchard Punsawad, Fendi Pradana, Sineenart Sanpinit
Herbal galactagogues have been widely used as a treatment for postpartum hypogalactia due to the potential side effects associated with pharmacological therapy. Tri-Than-Thip (Tri-TT) is a Thai herbal medicine remedy that contains three main components: Cassia fistula, Pithecellobium dulce, and Ficus benjamina . These components are believed to have properties that contribute to milk production. However, despite the traditional use of Tri-TT, there is a lack of academic evidence supporting its efficacy in enhancing milk production...
2023: International Journal of Medical Sciences
#39
JOURNAL ARTICLE
Aysha Aslam, Muhammad Umer Ashraf, Kashif Barkat, Asif Mahmood, Rai Muhammad Sarfraz, Rania T Malatani, Heba A Gad
The present study aims to utilize green synthesis to fabricate stimuli-responsive, smart, quince/pectin cross-linked hydrogel sponges for the pH-regulated conveyance of domperidone. The designed hydrogel sponges were evaluated for a sol-gel fraction (%), swelling studies and kinetics, drug loading (%), electrolyte-responsive character, scanning electron microscopy (SEM), thermal analysis, and drug-excipient compatibility studies (FTIR), X-ray diffraction (XRD) analysis, mechanical testing, in-vitro drug release studies, acute oral toxicity studies...
August 10, 2023: International Journal of Pharmaceutics
#40
JOURNAL ARTICLE
Ewerton Fylipe de Araújo Silva, José Anderson da Silva Gomes, Maria Luísa Figueira de Oliveira, Arthur Gabriel Alves Furtado de Carvalho Noya, Carolina Peixoto Magalhães, João Vitor da Silva, Luiz Henrique da Silva, Bruno Mendes Tenorio, Marcelo Moraes Valença, Fernanda das Chagas Angelo Mendes Tenorio
Hyperprolactinemia is a pathological condition resulting from increased prolactin that directly affects reproduction, as this condition inhibits the release of LH, FSH and gonadal steroidogenesis, bringing several negative clinical associations in reproduction. In contrast, melatonin (MEL) plays an important role in the regulation of steroidogenesis and modulates damages to the process of spermatogenesis. The objective was to analyze the protective effects of exogenous melatonin on the testis of hyperprolactinemic adult rats...
September 2023: Reproductive Biology
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