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https://www.readbyqxmd.com/read/29036974/-the-impact-of-hydrogen-sulfide-on-the-heme-oxygenase-1-carbon-monoxide-system-in-coxsackie-virus-b3-induced-myocarditis-in-mice
#1
S Y Zhang, T T Wu, Y Ren, T H Xia, R Z Wu
Objective: To explore the impact of hydrogen sulfide (H(2)S) on the heme oxygenase-1/carbon monoxide pathway in Coxsackie virus B3 (CVB3)-induced murine myocarditis (VMC) model. Method: A total of 70 inbred male Balb/c mouse (4-6 weeks old) were randomized into the following four groups: Normal, VMC, PAG and NaHS (n=10 for Normal, n=20 for VMC, PAG and NaHS groups). Mice in Normal group were non-infected mice treated with intraperitoneal injection of sterile phosphate-buffered saline daily for 10 days.Mice in VMC group received intraperitoneal CVB3 injection (0...
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29036862/naval-special-warfare-nsw-crewmen-demonstrate-diminished-cervical-strength-and-range-of-motion-compared-to-nsw-students
#2
Shawn R Eagle, Takashi Nagai, Paul Morgan, Renee Hendershot, Timothy C Sell
BACKGROUND: Cumulative effects of high-impact vertical forces, like those experienced on an open-ocean mission, could be an injury concern for the cervical spine. OBJECTIVE: Compare cervical range of motion (ROM) and strength measures between students and NSW Crewmen and secondarily to compare these measures between students and Crewmen separated into three groups based on years of service. METHODS: A volunteer sample of 186 students (age: 22...
October 9, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036861/task-intensity-influences-upper-limb-and-torso-kinematics-during-two-common-overhead-functional-capacity-evaluation-tasks
#3
Angelica E Lang, Clark R Dickerson
BACKGROUND: The Functional Capacity Evaluation (FCE) is a tool used in the return-to-work process to guide treatment and decision making. Individual abilities and maximum capacity can be determined through visual observations of changes in mechanics as intensity increases. OBJECTIVE: The purpose of this study was to determine kinematic differences between sexes and intensity levels of two common FCE tasks to establish normative behaviours. METHODS: Upper limb and torso kinematics were collected from 30 participants as they performed the overhead lift and overhead work FCE tasks...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036548/acute-response-to-a-2-minute-isometric-exercise-test-predicts-the-blood-pressure-lowering-efficacy-of-isometric-resistance-training-in-young-adults
#4
Yasina B Somani, Anthony W Baross, Robert D Brook, Kevin J Milne, Cheri L McGowan, Ian L Swaine
Background: This work aimed to explore whether different forms of a simple isometric exercise test could be used to predict the blood pressure (BP)-lowering efficacy of different types of isometric resistance training (IRT) in healthy young adults. In light of the emphasis on primary prevention of hypertension, identifying those with normal BP who will respond to IRT is important. Also, heightened BP reactivity increases hypertension risk, and as IRT reduces BP reactivity in patients with hypertension, it warrants further investigation in a healthy population...
September 27, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29036112/improving-color-constancy-by-discounting-the-variation-of-camera-spectral-sensitivity
#5
Shao-Bing Gao, Ming Zhang, Chao-Yi Li, Yong-Jie Li
It is an ill-posed problem to recover the true scene colors from a color biased image by discounting the effects of scene illuminant and camera spectral sensitivity (CSS) at the same time. Most color constancy (CC) models have been designed to first estimate the illuminant color, which is then removed from the color biased image to obtain an image taken under white light, without the explicit consideration of CSS effect on CC. This paper first studies the CSS effect on illuminant estimation arising in the inter-dataset-based CC (inter-CC), i...
August 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29035708/an-assessment-of-the-utilization-of-the-preclinical-rodent-model-literature-in-clinical-trials-of-putative-therapeutics-for-the-treatment-of-alcohol-use-disorders
#6
Ashley M Barajaz, Christopher L Kliethermes
OBJECTIVE: Rodent models of Alcohol Use Disorders (AUD) are used extensively by preclinical researchers to develop new therapeutics for the treatment of AUD. Although these models play an important role in the development of novel, targeted therapeutics, their role in bringing therapeutics to clinical trials is unclear, as off-label use of existing medications not approved for the treatment of AUD is commonly seen in the clinic and clinical trials. METHOD: In the current study, we used the Clinicaltrials...
October 12, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29035703/a-randomized-clinical-trial-examining-the-effects-of-an-anxiety-sensitivity-intervention-on-insomnia-symptoms-replication-and-extension
#7
Nicole A Short, Joseph W Boffa, Savannah King, Brian J Albanese, Nicholas P Allan, Norman B Schmidt
Insomnia disorder is impairing and prevalent, particularly among individuals with comorbid anxiety disorders. Despite the availability of effective computerized treatments for insomnia, there are few that target both insomnia as well as co-occurring anxiety symptoms. The current study tests the efficacy of a computerized treatment for anxiety sensitivity cognitive concerns, a transdiagnostic risk factor for anxiety, mood, and insomnia symptoms, against a repeated contact control, on reducing insomnia symptoms...
October 5, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29035324/a-mesoscopic-analytical-model-to-predict-the-onset-of-wrinkling-in-plain-woven-preforms-under-bias-extension-shear-deformation
#8
Abbas Hosseini, Masoud Haghi Kashani, Farrokh Sassani, Abbas S Milani, Frank Ko
A mesoscopic analytical model of wrinkling of Plain-Woven Composite Preforms (PWCPs) under the bias extension test is presented, based on a new instability analysis. The analysis is aimed to facilitate a better understanding of the nature of wrinkle formation in woven fabrics caused by large in-plane shear, while it accounts for the effect of fabric and process parameters on the onset of wrinkling. To this end, the mechanism of wrinkle formation in PWCPs in mesoscale is simplified and an equivalent structure composed of bars and different types of springs is proposed, mimicking the behavior of a representative PWCP element at the post-locking state...
October 16, 2017: Materials
https://www.readbyqxmd.com/read/29035234/a-generalized-methodology-for-data-analysis
#9
Plamen P Angelov, Xiaowei Gu, Jose C Pr
Based on a critical analysis of data analytics and its foundations, we propose a functional approach to estimate data ensemble properties, which is based entirely on the empirical observations of discrete data samples and the relative proximity of these points in the data space and hence named empirical data analysis (EDA). The ensemble functions include the nonparametric square centrality (a measure of closeness used in graph theory) and typicality (an empirically derived quantity which resembles probability)...
October 12, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/29034810/adult-idiopathic-cholestasis-a-condition-more-common-in-the-canadian-inuit
#10
Gerald Y Minuk, Galia Pollock, Julia Uhanova
Despite extensive investigations, some patients have no identifiable cause for their cholestatic liver enzyme abnormalities. The aim of this study was to document the clinical, laboratory, radiologic and histologic features of adult patients with idiopathic cholestasis (AIC). A computerised database of referred patients to a tertiary care hospital outpatient department for assessment of hepatobiliary disorders between 2005 and 2015 was employed to identify and describe features associated with AIC. Of 6,560 patient referrals, sufficient documentation to warrant a diagnosis of AIC was present in 17 (0...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/29034645/peripheral-neuropathy-in-multiple-sclerosis-an-electrophysiologic-study-in-iranian-patients
#11
Mohammad Reza Emad, Leila Zeinali, Alireza Nikseresht, Mahshid Naseri, Hajar Karimian
Multiple sclerosis (MS) is the most common cause of disability after trauma in young adults in Northern Hemisphere; it imposes a major burden on the affected young people. A significant association between MS and demyelinating peripheral neuropathy which might be due to common pathogenesis for the central and peripheral nerves demyelination has been reported in several studies. We aimed to assess if there is any peripheral nervous system involvement in a sample of Iranian MS population. Extensive nerve conduction studies (NCS) were conducted in 20 MS patients according to McDonald criteria, and 20 age and gender matched healthy appearing controls...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29034606/do-mid-crown-enamel-formation-front-angles-reflect-factors-linked-to-the-pace-of-primate-growth-and-development
#12
Debbie Guatelli-Steinberg, James D Pampush, Mackie C O'Hara, Song Xing, W Scott McGraw, Rebecca J Ferrell
Enamel formation front (EFF) angles represent the leading edge of enamel matrix secretion at particular points in time. These angles are influenced by rates of enamel extension (the rates at which tooth crowns grow in height), rates of enamel matrix secretion and the angles that prisms make with the enamel-dentine junction. Previous research suggests, but has not yet established, that these angles reflect aspects of primate biology related to their pace of growth and development, most notably brain and body size...
October 16, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29034272/influence-of-head-position-on-the-cbct-accuracy-in-assessment-of-the-proximity-of-the-root-apices-to-the-inferior-alveolar-canal
#13
Sadaf Adibi, Shoaleh Shahidi, Saeed Nikanjam, Maryam Paknahad, Mohammadali Ranjbar
STATEMENT OF THE PROBLEM: The most important risk factor for inferior alveolar nerve (IAN) damage is the proximity of the mandibular root apices to the alveolar canal. Failure to position the patient's head at standardized orientation during cone beam computed tomography (CBCT) scans might adversely affect the relative position of the alveolar canal and mandibular root apices with subsequent treatment failure. PURPOSE: The purpose of the present study was to investigate the influence of the orientations of the skull during the scanning procedure on the accuracy of CBCT images in determining the positional relationship of the mandibular tooth apices to the alveolar canal...
September 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29034209/bridge-induced-translocation-between-nup145-and-top2-yeast-genes-models-the-genetic-fusion-between-the-human-orthologs-associated-with-acute-myeloid-leukemia
#14
Valentina Tosato, Nicole West, Jan Zrimec, Dmitri V Nikitin, Giannino Del Sal, Roberto Marano, Michael Breitenbach, Carlo V Bruschi
In mammalian organisms liquid tumors such as acute myeloid leukemia (AML) are related to spontaneous chromosomal translocations ensuing in gene fusions. We previously developed a system named bridge-induced translocation (BIT) that allows linking together two different chromosomes exploiting the strong endogenous homologous recombination system of the yeast Saccharomyces cerevisiae. The BIT system generates a heterogeneous population of cells with different aneuploidies and severe aberrant phenotypes reminiscent of a cancerogenic transformation...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29033953/development-and-characterization-of-transgenic-sugarcane-with-insect-resistance-and-herbicide-tolerance
#15
Wen Zhi Wang, Ben Peng Yang, Xiao Yan Feng, Zheng Ying Cao, Cui Lian Feng, Jun Gang Wang, Guo Ru Xiong, Lin Bo Shen, Jun Zeng, Ting Ting Zhao, Shu Zhen Zhang
Genetically modified crops which had been commercial applied extensively majorly are the insect resistance and herbicide tolerance events. In this study, the Bt insecticidal gene Cry1Ab, the glyphosate-tolerant gene EPSPS, and the selection marker gene PMI were combined into a single transferred DNA fragment and introduced into sugarcane by Agrobacterium-mediated transformation. Thirty-three resistant plantlets were obtained after selection using a PMI/mannose selection system. Thirty of these resistant plantlets were PCR positive for the three target genes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29033601/urine-metabolic-ratio-of-omeprazole-in-relation-to-cyp2c19-polymorphisms-in-russian-peptic-ulcer-patients
#16
Natalia P Denisenko, Dmitriy A Sychev, Zhanna M Sizova, Valeriy V Smirnov, Kristina A Ryzhikova, Zhannet A Sozaeva, Elena A Grishina
BACKGROUND: CYP2C19 is known to be the main enzyme of biotransformation of proton pump inhibitors (PPIs), whereas the CYP2C19 gene is highly polymorphic. Genotyping and phenotyping together represent more reliable data about patient's CYP2C19 activity. PURPOSE: The aim of the study was to investigate the applicability of urine metabolic ratio of omeprazole for CYP2C19 phenotyping in Russian peptic ulcer patients with different CYP2C19 genotypes. PATIENTS AND METHODS: A total of 59 patients (19 men and 40 women) aged 18-91 years (mean age 53...
2017: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/29032903/single-shot-femoral-nerve-block-does-not-cause-long-term-strength-and-functional-deficits-following-anterior-cruciate-ligament-reconstruction
#17
Kelechi R Okoroha, Lafi Khalil, Edward K Jung, Robert A Keller, Nathan E Marshall, Moneer Abouljoud, Derek Chan, Vasilios Moutzouros
PURPOSE: To determine if patients treated with a single-shot femoral nerve block have strength and functional deficits at 9-month follow-up. METHODS: Forty-three patients who underwent primary anterior cruciate ligament reconstructions were randomized to receive either a preoperative single-shot femoral nerve block or local infiltration anesthesia for primary pain control. All patients underwent a standardized comprehensive rehabilitation program postoperatively...
October 9, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29032304/heterocyclic-homoprostanoid-derivative-attenuates-monoarthritis-in-rats-an-in-vitro-and-in-vivo-preclinical-paradigm
#18
Jayesh Mudgal, S A Manohara Reddy, Geetha Mathew, Anoop Kishore, C Mallikarjuna Rao, Gopalan K Nampurath
From our lab, among the nineteen heterocyclic homoprostanoids (HHPs), three derivatives (compounds 3, 3b and 3c) exerted antioxidant and anti-inflammatory activity. Present study is an extension of the earlier work, and, is designed to establish their therapeutic potential in monoarthritis in rats. In addition, their possible mechanism of action would be investigated. A battery of in vitro tests such as lipopolysaccharide (LPS)-induced nitrite (NO)/reactive oxygen species (ROS) and NO/interleukin (IL)-6 generation in murine macrophages and whole blood (WhB), respectively were conducted...
October 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29031994/clinical-classification-criteria-for-neurogenic-claudication-caused-by-lumbar-spinal-stenosis-the-n-class-criteria
#19
Stéphane Genevay, Delphine S Courvoisier, Kika Konstantinou, Francisco M Kovacs, Marc Marty, James Rainville, Michael Norberg, Jean-François Kaux, Thomas D Cha, Jeffrey N Katz, Steven J Atlas
BACKGROUND CONTEXT: Since imaging findings of lumbar spinal stenosis (LSS) may not be associated with symptoms, clinical classification criteria based on patient symptoms and physical examination findings are needed. PURPOSE: To develop clinical classification criteria that identify patients with neurogenic claudication (NC) caused by LSS. STUDY DESIGN: Two stage process. Phase 1: Delphi process; Phase 2: cross-sectional study. PATIENT SAMPLE: Outpatients recruited from spine clinics in 5 countries...
October 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29031637/molecular-epidemiology-of-multi-and-extensively-drug-resistant-mycobacterium-tuberculosis-in-ireland-2001-2014
#20
E Roycroft, R F O'Toole, M M Fitzgibbon, L Montgomery, M O'Meara, P Downes, S Jackson, J O'Donnell, I F Laurenson, A M McLaughlin, J Keane, T R Rogers
OBJECTIVES: The primary objective of this work was to examine the acquisition and spread of multi-drug resistant (MDR) tuberculosis (TB) in Ireland. METHODS: All available Mycobacterium tuberculosis complex (MTBC) isolates (n=42), from MDR-TB cases diagnosed in Ireland between 2001 and 2014, were analysed using phenotypic drug-susceptibility testing, Mycobacterial-Interspersed-Repetitive-Units Variable-Number Tandem-Repeat (MIRU-VNTR) genotyping, and whole-genome sequencing (WGS)...
October 11, 2017: Journal of Infection
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