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https://www.readbyqxmd.com/read/28454296/association-between-braf-v600e-mutation-and-the-clinicopathological-features-of-solitary-papillary-thyroid-microcarcinoma
#1
Hai-Zhen Lu, Tian Qiu, Jian-Ming Ying, Ning Lyn
The B-Raf proto-oncogene serine/threonine kinase (BRAF)(V600E) mutation is an important oncogene in the development of papillary thyroid carcinoma (PTC) and has been identified as a risk factor for poor prognosis in patients with PTC. However, whether the BRAF(V600E) mutation is a prognostic marker in patients with solitary papillary thyroid microcarcinoma (sPTMC) has not yet been established. The present study aimed to identify the association between BRAF(V600E) mutation and the clinicopathological features of patients with sPTMC...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453246/robust-and-flexible-aramid-nanofiber-graphene-layer-by-layer-electrodes
#2
Se Ra Kwon, Meagan Elinski, James D Batteas, Jodie L Lutkenhaus
Aramid nanofibers (ANFs), or nanoscale Kevlar® fibers, are of interest for its high mechanical performance and functional nanostructure. The dispersible nature of ANFs opens up processing opportunities for creating mechanically robust and flexible nanocomposites, particularly for energy and power applications. The challenge is to manipulate ANFs into an electrode structure that balances mechanical and electrochemical performance to yield a robust and flexible electrode. Here, ANFs and graphene oxide (GO) sheets are blended using layer-by-layer (LbL) assembly to achieve mechanically flexible supercapacitor electrodes...
April 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28449236/discovery-of-lhrh-and-development-of-lhrh-analogs-for-prostate-cancer-treatment
#3
Andrew V Schally, Norman L Block, Ferenc G Rick
The discovery, isolation, elucidation of structure, synthesis, and initial testing of the neuropeptide hypothalamic luteinizing hormone-releasing hormone (LHRH), which regulates reproduction, is briefly described. The design, synthesis, and experimental and clinical testing of agonistic analogs of LHRH is extensively reviewed focusing on the development of new methods for the treatment of prostate cancer. Subsequent development of antagonistic analogs of LHRH is then faithfully recounted with special emphasis on therapy of prostate cancer and BPH...
April 27, 2017: Prostate
https://www.readbyqxmd.com/read/28448921/novel-bone-surrogates-for-cranial-surgery-training
#4
Marianne Hollensteiner, David Fürst, Benjamin Esterer, Peter Augat, Falk Schrödl, Stefan Hunger, Michael Malek, Daniel Stephan, Andreas Schrempf
Parietal graft lifts are trained on human or animal specimens or are directly performed on patients without extensive training. In order to prevent harm to the patient resulting from fast rotating machinery tools, the surgeon needs to apply appropriate forces. Realistic haptics are essential to identify the varying parietal bone layers and to avoid a penetration of the brain. This however, requires experience and training. Therefore, in this study, bone surrogate materials were evaluated with the aim to provide an anatomically correct artificial skull cap with realistic haptic feedback for graft lift training procedures...
April 19, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28448908/biological-impacts-of-glyphosate-on-morphology-embryo-biomechanics-and-larval-behavior-in-zebrafish-danio-rerio
#5
Shuhui Zhang, Jia Xu, Xiangyu Kuang, Shibao Li, Xiang Li, Dongyan Chen, Xin Zhao, Xizeng Feng
All of these days, residues of herbicides such as glyphosate are widely distributed in the environment. The ubiquitous use of glyphosate has drawn extensive attention to its toxicity as an organic pollutant. In this study, we employed larval zebrafish as an animal model to evaluate the effect of different concentrations of glyphosate on early development via morphological, biomechanics, behavioral and physiological analyses. Morphological results showed that an obvious delay occurred in the epiboly process and body length, eye and head area were reduced at concentrations higher than 10 mg/L...
April 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28448853/a-cluster-of-aspartic-residues-in-the-extracellular-loop-ii-of-par-4-is-important-for-thrombin-interaction-and-activation-of-platelets
#6
Daniel Sánchez Centellas, Sushanth Gudlur, Alejandro Vicente-Carrillo, Sofia Ramström, Tomas L Lindahl
Thrombin activates platelets via proteolytic cleavage of protease-activated receptors (PARs) 1 and 4. The two PARs have distinct but complementary roles. The mechanisms responsible for PAR1 activation by thrombin have been extensively studied. However, much less is known regarding thrombin activation of PAR4, especially the potential involvement of regions of PAR4 other than the N-terminal, which is bound to the catalytic site of thrombin. We have studied PAR4 in S. cerevisiae strain MMY12, an expression system in which the GPCR receptors are connected to a Lac Z reporter gene resulting in increased β-galactosidase activity...
April 13, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28448852/reproducibility-of-scapular-muscle-activity-in-isokinetic-shoulder-flexion-and-extension
#7
Monique Wochatz, Sophie Rabe, Martin Wolter, Tilman Engel, Steffen Mueller, Frank Mayer
Repetitive overhead movements have been identified as a main risk factor to develop shoulder complaints with scapular muscle activity being altered. Reliable assessment of muscle activity is essential to differentiate between symptomatic and asymptomatic individuals. Therefore, the present study aimed to investigate the intra- and inter-session reliability of scapular muscle activity during maximal isokinetic shoulder flexion and extension. Eleven asymptomatic adults performed maximum effort isokinetic shoulder flexion and extension (concentric and eccentric at 60°/s) in a test-retest design...
April 13, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28448851/accurate-3d-reconstruction-of-bony-surfaces-using-ultrasonic-synthetic-aperture-techniques-for-robotic-knee-arthroplasty
#8
William Kerr, Philip Rowe, Stephen Gareth Pierce
Robotically guided knee arthroplasty systems generally require an individualized, preoperative 3D model of the knee joint. This is typically measured using Computed Tomography (CT) which provides the required accuracy for preoperative surgical intervention planning. Ultrasound imaging presents an attractive alternative to CT, allowing for reductions in cost and the elimination of doses of ionizing radiation, whilst maintaining the accuracy of the 3D model reconstruction of the joint. Traditional phased array ultrasound imaging methods, however, are susceptible to poor resolution and signal to noise ratios (SNR)...
April 19, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28448799/isolation-of-antioxidant-phenolics-from-schinopsis-brasiliensis-based-on-a-preliminary-lc-ms-profiling
#9
Clisiane Carla de Souza Santos, Milena Masullo, Antonietta Cerulli, Angela Mari, Charles Dos Santos Estevam, Cosimo Pizza, Sonia Piacente
The phenolic content of the ethanol extract of the stem bark of the Brazilian plant Schinopsis brasiliensis Engl. (Anacardiaceae) has been evaluated together with the antioxidant activity. The good antioxidant activity exhibited in the Trolox Equivalent Antioxidant Capacity (TEAC) assay (TEAC value = 3.04 mg/mL) encouraged us to investigate its constituents. An analytical approach based on LC-ESIMS(n) was applied to rapidly obtain a metabolite profile of the ethanol extract of the stem bark of S. brasiliensis...
April 24, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28448759/ft3-is-higher-in-males-than-in-females-and-decreases-over-the-lifespan
#10
David Strich, Gilad Karavani, Shalom Edri, Cherut Chay, David Gillis
OBJECTIVE: Normal changes in Free triiodothyronine (FT3), Free thyroxine (FT4) and thyroid stimulating hormone (TSH) levels over the lifespan and differences between genders are not well documented, mainly because even the largest-scale studies available include relatively small cohorts. The aim of this study was to define age-related trends including gender differences based on reliable data. METHODS: A large database including serum thyroid tests drawn in community clinics was studied...
April 27, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28448687/postexercise-blood-flow-restriction-does-not-enhance-muscle-hypertrophy-induced-by-multiple-set-high-load-resistance-exercise
#11
Haruhiko Madarame, Satoshi Nakada, Takahisa Ohta, Naokata Ishii
To test the applicability of postexercise blood flow restriction (PEBFR) in practical training programmes, we investigated whether PEBFR enhances muscle hypertrophy induced by multiple-set high-load resistance exercise (RE). Seven men completed an eight-week RE programme for knee extensor muscles. Employing a within-subject design, one leg was subjected to RE + PEBFR, whereas contralateral leg to RE only. On each exercise session, participants performed three sets of unilateral knee extension exercise at approximately 70% of their one-repetition maximum for RE leg first, and then performed three sets for RE + PEBFR leg...
April 27, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28448138/idp-specific-force-field-ff14idpsff-improves-the-conformer-sampling-of-intrinsically-disordered-proteins
#12
Dong Song, Ray Luo, Hai-Feng Chen
Intrinsically disordered proteins (IDPs) or intrinsically disordered regions have not fixed tertiary structure, but play key roles in signal regulation, molecule recognition, and drug target. However it is difficult to study the structure and function of IDPs by traditional experimental methods because of their diverse conformations. Limitations of current generic protein force fields and solvent models were reported in the previous simulations of IDPs. We have also explored to overcome these limitations by developing ff99IDPs and ff14IDPs force fields to correct the dihedral distribution for eight disordered promoting residues often observed in IDPs and found encouraging improvements...
April 27, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28447859/transgene-expression-in-dogs-after-liver-directed-hydrodynamic-delivery-of-i-sleeping-beauty-i-transposons-using-balloon-catheters
#13
Kendra Anne Hyland, Elena L Aronovich, Erik R Olson, Jason B Bell, Myra Urness Rusten, Roland Gunther, David W Hunter, Perry B Hackett, R Scott McIvor
The <i>Sleeping Beauty</i> transposon system has been extensively tested for integration of reporter and therapeutic genes <i>in vitro</i> and <i>in vivo</i> in mice. Dogs were used as a large animal model for human therapy and minimally invasive infusion of DNA solutions. DNA solutions were delivered into the entire liver or the left side of the liver using balloon catheters for temporary occlusion of venous outflow. A peak intravascular pressure between 80 and 140 mmHg supported sufficient DNA delivery in dog liver for detection of secretable reporter proteins...
April 27, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28447186/comparison-of-the-recovery-response-from-high-intensity-and-high-volume-resistance-exercise-in-trained-men
#14
Sandro Bartolomei, Eliahu Sadres, David D Church, Eliott Arroyo, Joseph A Gordon Iii, Alyssa N Varanoske, Ran Wang, Kyle S Beyer, Leonardo P Oliveira, Jeffrey R Stout, Jay R Hoffman
PURPOSE: The purpose of this study was to compare the physiological responses of a high-volume (HV; 8 sets of 10 repetitions) versus high-intensity (HI; 8 sets of 3 repetitions) exercise protocol in resistance-trained men. METHODS: Twelve men (24.5 ± 4.2 years; 82.3 ± 8.4 kg; 175.2 ± 5.5 cm) with 6.3 ± 3.4 years of resistance training experience performed each protocol in a counterbalanced, randomized order. Performance [counter movement jump peak power (CMJP), isokinetic (ISOK) and isometric leg extension (MVIC), isometric mid-thigh pull (IMTP), and isometric squat (ISQ)] and muscle morphological [cross-sectional area (CSA) of vastus lateralis] assessments were performed at baseline (BL), 30-min (P-30 min), 24-h (P-24 h), 48-h (P-48 h), and 72-h (P-72 h) post-exercise for each testing session...
April 26, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28446970/the-role-of-endobronchial-ultrasound-versus-mediastinoscopy-for-non-small-cell-lung-cancer
#15
REVIEW
Katarzyna Czarnecka-Kujawa, Kazuhiro Yasufuku
This review provides an update on the current role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and mediastinoscopy (Med) in assessment of patients with non-small cell lung cancer (NSCLC). Invasive mediastinal lymph node (LN) staging is the major application for both of these techniques. Up until recently, Med was the gold standard for invasive mediastinal LN staging in NSCLC. However, EBUS-TBNA has shown to be equivalent, and in some studies better than Med for invasive staging of lung cancer...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28446889/the-stroop-color-and-word-test
#16
REVIEW
Federica Scarpina, Sofia Tagini
The Stroop Color and Word Test (SCWT) is a neuropsychological test extensively used to assess the ability to inhibit cognitive interference that occurs when the processing of a specific stimulus feature impedes the simultaneous processing of a second stimulus attribute, well-known as the Stroop Effect. The aim of the present work is to verify the theoretical adequacy of the various scoring methods used to measure the Stroop effect. We present a systematic review of studies that have provided normative data for the SCWT...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28446574/the-use-of-genexpert-remnants-for-drug-resistance-profiling-and-molecular-epidemiology-of-tuberculosis-in-libreville-gabon
#17
Amel Kévin Alame-Emane, Catherine Pierre-Audigier, Oriane Cordelia Aboumegone-Biyogo, Amandine Nzoghe-Mveang, Véronique Cadet-Daniel, Christophe Sola, Joël Fleury Djoba-Siawaya, Brigitte Gicquel, Howard E Takiff
Multidrug (MDR) and extensively drug resistant (XDR) Mycobacterium tuberculosis are major problems in global health. The GeneXpertMTB/RIF (Xpert) rapidly detects resistance to rifampicin (RIF-R), but detection of the additional resistance that defines MDR and XDR-TB, and for molecular epidemiology, specimen cultures and biosafe infrastructure are generally required. We sought to determine whether the remnants of sputa prepared for Xpert could be used directly to find mutations associated with drug resistance and for molecular epidemiology, and thus provide a precise characterization of MDR-TB cases in countries lacking BSL3 facilities for M...
April 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28446569/differentiated-levels-of-ganciclovir-resistance-conferred-by-mutations-at-codons-591-603-of-the-cytomegalovirus-ul97-kinase-gene
#18
Sunwen Chou, Ronald J Ercolani, Adam L Vanarsdall
Diagnostic mutations in the cytomegalovirus UL97 kinase gene are used to assess the level of associated ganciclovir resistance and therapeutic options. The best-known mutations at codons 460, 520 or 591-607 individually confer 5- to 10-fold decreased ganciclovir susceptibility, except 3-fold in the case of amino acid substitution C592G. Less common point and in-frame deletion mutations at codons 591-603 remain incompletely characterized. The ganciclovir susceptibilities of 17 mutants in this codon range were evaluated by use of the same recombinant phenotyping system and extensive assay replicates in two types of cell cultures...
April 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28446479/severe-chronic-diarrhoea-secondary-to-primary-lymph-node-gastrinoma
#19
Mouhanna Abu Ghanimeh, Khalil Abuamr, Esmat Sadeddin, Osama Yousef
The existence of primary lymph node (LN) gastrinoma is questionable and controversial. In fact, the presence of gastrinoma in such uncommon site raises the possibility of metastasis from another occult primary site. An extensive evaluation and careful follow-up is always warranted. A female aged 48 years presented with chronic abdominal pain and watery diarrhoea. Her serum gastrin and chromogranin were elevated, and an underlying gastrinoma was suspected. Further evaluation with an octreotide scan, an endoscopic ultrasound and a secretin stimulation test confirmed the diagnosis...
April 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28446036/fusaripeptide-a-new-antifungal-and-anti-malarial-cyclodepsipeptide-from-the-endophytic-fungus-fusarium-sp
#20
Sabrin R M Ibrahim, Hossam M Abdallah, Ehab S Elkhayat, Nawal M Al Musayeib, Hani Z Asfour, Mohamed F Zayed, Gamal A Mohamed
From the culture of the endophytic fungus Fusarium sp. isolated from the roots of Mentha longifolia L. (Labiatae) growing in Saudi Arabia, a new cyclodepsipeptide, namely fusaripeptide A (1), along with three known compounds adenosine (2), 2[(2-hydroxypropionyl)amino]benzamide (3), and cyclopentanol (4), have been isolated. Their structures were determined, using extensive 1D and 2D NMR and HRESI and GC mass spectral data. That is the first report for the isolation of compound 4 from natural source. In addition, compounds 2 and 3 are reported here for the first time from Fusarium sp...
April 27, 2017: Journal of Asian Natural Products Research
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