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M Arenbergerova, I Mrazova, J Horazdovsky, E Sticova, A Fialova, P Arenberger
Vemurafenib is a selective inhibitor of the BRAF-kinase approved for the treatment of metastatic melanoma harboring BRAF mutation. Skin toxicity, including maculopapular exanthema, photosensitivity and keratoacanthoma, are the most common treatment-related adverse events of vemurafenib, affecting more than 90% of patients (1,2). It rarely presents with intense severity, with less than 1% of grade-4 toxicities reported in clinical trials (3,4). This article is protected by copyright. All rights reserved.
October 14, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
C Noell, C Chen, R Sells, A Mikailov, D Kroshinsky
Vemurafenib is a kinase inhibitor that targets the BRAF V600E mutation and is a promising treatment option for metastatic melanoma. To date, various cutaneous side effects have been reported including photosensitivity, cutaneous squamous cell carcinoma, and keratoacanthomas [1]. However, to the best of our knowledge, there have been no reports in the literature of an acneiform-eruption exhibiting locus minorus resistentiae (LMR) following vemurafenib treatment and radiation therapy. LMR is defined as an area of decreased resistance, and describes an anatomical site that was previously injured and now exhibits increased susceptibility to a variety of inflammatory processes, such as medication reactions or infection [2]...
September 9, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
S Pinar Bilir, Qiufei Ma, Zhongyun Zhao, Elizabeth Wehler, Julie Munakata, Beth Barber
BACKGROUND: Little has been reported on the costs of managing the adverse events (AEs) associated with current therapies for patients with regional or distant metastatic melanoma. OBJECTIVES: To identify treatment-related AEs in patients with metastatic melanoma and to estimate the associated costs of treating these AEs in the United States. METHODS: A cost-estimation study for AEs associated with treatment of metastatic melanoma was conducted from 2012 to 2013 by identifying grades 3 and 4 AEs through the use of a comprehensive search of drug labels and English-language, published phase 2/3 studies in PubMed, conference abstracts, and the National Comprehensive Cancer Network guidelines...
June 2016: American Health & Drug Benefits
Chaw-Ning Lee, Shin-Chen Pan, Julia Yu-Yun Lee, Tak-Wah Wong
BACKGROUND: Wide excision or Mohs surgery is the standard treatment of skin squamous cell carcinoma (SCC). Superficial SCC or tumor smaller than 1 cm has been treated successfully with open spray cryosurgery. Larger tumor may not be as effective because tissue destruction is usually superficial. Intralesional cryosurgery (IC) may provide a deeper and better cell killing effect in larger tumors. We investigated the safety and efficacy of treating nodular SCC in 4 patients with IC. METHODS: Four patients with nodular SCC/keratoacanthoma (tumor size, 1-2...
September 2016: Medicine (Baltimore)
Jean-Philip Lacroix, Beatrice Wang
BACKGROUND: Dabrafenib, a novel selective small-molecule inhibitor of BRAF, has been shown to increase overall survival in patients with unresectable metastatic melanoma harboring the BRAF V600E mutation. The development of resistance has led to combination therapy with selective MEK inhibitor trametinib. Compared with vemurafenib, dabrafenib is a more recent BRAF inhibitor approved by the Food and Drug Administration in May 2013 for metastatic melanoma; fewer data are available in the current literature regarding cutaneous toxicity...
September 13, 2016: Journal of Cutaneous Medicine and Surgery
Bengu Nisa Akay, Secil Saral, Aylin O Heper, Cengizhan Erdem, Cliff Rosendahl
Basosquamous carcinoma (BSC) is a rare skin cancer which has areas of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) and a transition zone between them. However, dermoscopic features of BSC are not well described in the published work, except one study. The aim of the present study was to better identify and clarify the dermoscopic findings of BSC in the largest group of patients in the published work and to describe its dermoscopic features according to histopathologically BCC-dominant, SCC-dominant and intermediate categories...
August 29, 2016: Journal of Dermatology
Sweta Hasmukh Rambhia, Kinjal Deepak Rambhia, Amit Gulati
No abstract text is available yet for this article.
July 2016: Indian Dermatology Online Journal
Audrey Detrixhe, Florence Libon, Marion Mansuy, Nazli Nikkels-Tassoudji, Andrée Rorive, Jorge E Arrese, Pascale Quatresooz, Marie-Annick Reginster, Arjen F Nikkels
Increased awareness among dermatologists as well as the development of dermoscopy and sequential dermoscopy have contributed significantly toward an increase in the diagnostic accuracy of pigmented melanoma and even of amelanotic melanoma. However, the dermatologist's nightmare is the small group of melanomas that present as common skin diseases, often associated with a significant delay in diagnosis and hence a poor prognosis. The study was carried out to prospectively assess the number of melanomas lacking any clinical suspicion of melanoma and to describe their clinical and histological features over a 6-year observation period in an University Tertiary Skin Cancer Center...
August 17, 2016: Melanoma Research
François Kuonen, Alana Durack, Olivier Gaide
No abstract text is available yet for this article.
August 1, 2016: European Journal of Dermatology: EJD
Jun-Han Lee, Joo-Hyung Lee, Sang Hyuk Lee, Sung Im Do, Sung-Dae Cho, Ola Forslund, Kyung-Soo Inn, Jeong-Sang Lee, Fang-Ming Deng, Jonathan Melamed, Jae U Jung, Joseph H Jeong
Squamous cell carcinoma (SCC) and keratoacanthoma (KA) (SCC/KA) research has been hampered mainly by our lack of understanding the underlying genetic and epigenetic alterations associated with SCC/KA development, as well as the lack of animal models that faithfully recapitulate histopathological features of human SCC/KA. Here, we show that TPL2 overexpression induced both cell transformation in immortalized human keratinocytes and SCC and KA-like cutaneous SCC (cSCC) development in mice. Mechanistically, activation of TPL2 downstream signaling pathways such as MEK/ERK MAPK, mTOR, NF-κB and p38 MAPK leads to TPL2-mediated cell transformation in immortalized human keratinocytes and tumorigenesis in mice...
August 8, 2016: Cancer Research
Ji-Hye Park, Jae Ho Lee, Youngkyoung Lim, You Jin Lee, Dong-Youn Lee
CD30+ lymphoproliferative disorders (LPD) represent a spectrum of T-cell lymphoma including lymphomatoid papulosis and anaplastic large cell lymphoma (ALCL). Epidermis overlying cutaneous CD30+ LPD often shows epidermal hyperplasia, hyperkeratosis, crusting, and ulceration and it is difficult to distinguish from carcinoma such as keratoacanthoma (KA) or squamous cell carcinoma (SCC). Several cases of pseudocarcinomatous hyperplasia mimicking KA or SCC in CD30+ LPD have been reported. The relationship between CD30+ LPD and epithelial proliferations has not yet well understood...
August 2016: Annals of Dermatology
Amy Kalowitz Bieber, David E Cohen, Jennifer A Stein
No abstract text is available yet for this article.
May 2016: JAAD Case Reports
Gokhan Ozge, Yusuf Uysal, Osman Melih Ceylan, Onder Onguru, Fatih Mehmet Mutlu
Keratoacanthomas rarely occur in the conjunctiva. We report a case of a 24-year-old man with a rapidly growing conjunctival mass. The tumor was excised with a safety margin to exclude squamous cell carcinoma and was histopathologically diagnosed as a keratoacanthoma. There has been no recurrence over 2 years of follow-up. To the best of our knowledge, he is the youngest patient to be diagnosed with conjunctival keratoacanthoma who had no known risk factors such as skin disorders, trauma, surgery, or infection...
May 2016: Arquivos Brasileiros de Oftalmologia
F Parry, D Saunière, D L Huertas Diaz, M Dandurand
Since 1950, the year of Grzybowski's syndrome description by Marian Grzybowski in Warsaw, 30 cases have been described in the literature. This syndrome belongs to the family of multiple generalized keratoacanthomas (KA). It occurs in adults between 50 and 70 years. Clinically, it presents as a rash of hundreds or thousands of small papules 1 to 2mm with well-defined, sometimes keratotic center. The onset is sudden, the evolution is progressive and chronic. It is accompanied by severe and persistent pruritus...
July 14, 2016: Annales de Chirurgie Plastique et Esthétique
Heather Schopper, Nicholas M Bontumasi, Mohammed Milhem, Karolyn A Wanat
No abstract text is available yet for this article.
May 2016: JAAD Case Reports
Recep Bedir, Hasan Güçer, İbrahim Şehitoğlu, Cüneyt Yurdakul, Pelin Bağcı, Pelin Üstüner
BACKGROUND: Distinguishing squamous cell carcinoma (SCC) from keratoacanthoma (KA) by histopathological features may not be sufficient for a differential diagnosis, as KAs may, in some cases, imitate well-differentiated SCCs. AIMS: In this study, we investigated whether the expression of the p16, p21, p27, p53 genes and a Ki-67 proliferation index are useful in distinguishing between these two tumors. STUDY DESIGN: Cross-sectional study. METHODS: Immunohistochemistry was used to investigate the expression of the p16, p21, p27, p53 genes and the Ki-67 proliferation index was investigated in well-differentiated SCC with KA-like features (n=40) and KA (n=30)...
March 2016: Balkan Medical Journal
Jan Beckervordersandforth, Sreedhar Pujari, Dorit Rennspiess, Ernst Jan M Speel, Véronique Winnepenninckx, Carlos Diaz, Wolfgang Weyers, Anke Maria Haugg, Anna Kordelia Kurz, Axel Zur Hausen
BACKGROUND: The recent discovery of the Merkel cell polyomavirus and its consistent association with Merkel cell carcinoma has drawn attention to the numerous recently discovered polyomaviruses and their possible involvement in the etiopathogenesis of non-melanoma skin cancer (NMSC). Data on the recently discovered human polyomavirus 6 (HPyV6) and its role in NMSC are sparse and in part controversial. METHODS: In the present study we tested a large number (n = 299) of NMSC specimens for the presence of human polyomavirus 6 (HPyV6) by DNA PCR and HPyV6 fluorescence in situ hybridization (FISH)...
2016: Diagnostic Pathology
M Klingner, G Hansel, J Schönlebe, U Wollina
Necrobiotic xanthogranuloma is a rare non-Langerhans-cell histiocytosis. A 62-year-old woman presented with yellowish erythematous plaques, nodules, and papules in the periorbital region and the extremities. She had a nodular tumor grown on the left upper lid that clinically resembled a keratoacanthoma. Histologically it was a xanthogranulomatous lesion. She suffered from monoclonal gammopathy of unknown significance of κ‑type. Treatment was realized with a combination of systemic dapsone/prednisolone and topical corticosteroids...
July 5, 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Jung-Min Shin, Dae-Kyoung Choi, Hye-Young Kang, Kyung-Cheol Sohn, Young Lee, Chang Deok Kim, Jeung-Hoon Lee, Byung Cheol Park
BACKGROUND: The exact physiological function of REIC/Dkk-3 in the development of squamous cell carcinoma(SCC) remains unclear. OBJECTIVE: We aimed to investigate the expression pattern and functional role of REIC/Dkk-3 in the development of SCC. METHODS: We stained normal skin, actinic keratosis (AK) and SCC tissue with REIC/Dkk-3. The proliferation and migration of SCC 12 over-expressed with REIC/Dkk-3 were observed. For in vivo study, SCC12 cells in PBS, SCC12 cells containing LacZ, and REIC/Dkk-3-transduced SCC 12 cells were injected intra-dermally into the left and right backside flanks of SCID mice respectively, and tumor growth was evaluated...
June 11, 2016: Journal of Dermatological Science
Pedro DE Vasconcelos, Luís Soares-Almeida, Paulo Filipe
No abstract text is available yet for this article.
August 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
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