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Keratoacanthoma

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https://www.readbyqxmd.com/read/29447627/lynch-syndrome-and-muir-torre-syndrome-an-update-and-review-on-the-genetics-epidemiology-and-management-of-two-related-disorders
#1
Stephanie Le, Umer Ansari, Aisha Mumtaz, Kunal Malik, Parth Patel, Amanda Doyle, Amor Khachemoune
Hereditary Nonpolyposis Colorectal Cancer (HNPCC), also known as Lynch Syndrome, is an autosomal dominant, tumor predisposing disorder usuallycaused by germline mutations in mismatch repair (MMR) genes. A subset of HNPCC, Muir-Torre Syndrome (MTS) also involves MMR gene defects and is generally accepted as a variant of HNPCC. MTS is typicallycharacterized by at least one visceral malignancy and one cutaneous neoplasm of sebaceous differentiation, with or without keratoacanthomas. In either version of the disorder, nonfunctional MMR systems lead tothe loss of genomic integrity, marked commonly by mismatches in repetitive DNA sequences, resulting in microsatellite instabilities...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29418015/inverted-follicular-keratoses-of-the-buttocks
#2
Marie Kenney, Elizabeth B Lester, Deborah L Cook
Inverted follicular keratosis is a benign follicular tumor. Tumors classically demonstrate lobulated, endophytic growth with squamous eddy formation. The histologic differential diagnosis includes irritated seborrheic keratosis, trichilemmoma, verruca vulgaris, squamous cell carcinoma, and keratoacanthoma. The clinical differential diagnosis includes verruca, molluscum contagiosum, follicular cyst, and squamous cell carcinoma. In the past, a predilection for the head and neck of elderly men has been reported...
February 8, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29369392/cutaneous-intravascular-cd30-t-cell-pseudolymphoma-occurring-in-a-regressing-keratoacanthoma
#3
A Kailas, D M Elston, S E Crater, C A Cerruto
Cutaneous intravascular CD30+ pseudolymphoma is an uncommon incidental finding that may mimic intravascular or angiotropic lymphoma. We describe a 78-year-old female with a traumatized regressing keratoacanthoma on her left cheek. A shave biopsy was performed which revealed intravascular staining of atypical lymphocytes positive for CD45, CD3 and CD30. Clinical exam revealed no other evidence of lymphoma, the patient denied constitutional symptoms, and routine blood work was normal. The patient is healthy and doing well 28 months after her first visit...
January 25, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29368221/successful-treatment-of-a-keratoacanthoma-with-electrochemotherapy-a-case-report
#4
Paola Pasquali, Enrico P Spugnini, Alfonso Baldi
INTRODUCTION: Few studies have evaluated the efficacy of intralesional bleomycin injection combined with electroporation for the treatment of cutaneous tumors. However, the phenomenon that electroporation can enhance the cytotoxicity of bleomycin in vivo by 300-700 fold has been intensely investigated. CASE PRESENTATION: Keratoacanthoma in an 86-year-old patient was treated with intralesional bleomycin combined with electroporation. Treatment consisted of local application of shorty and intense electric pulses followed by local injection of bleomycin...
January 24, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29333623/evaluation-of-universal-immunohistochemical-screening-of-sebaceous-neoplasms-in-a-service-setting
#5
K Schon, E Rytina, J Drummond, J Simmonds, S Abbs, R Sandford, M Tischkowitz
BACKGROUND: Muir-Torre syndrome (MTS) is a subtype of Lynch syndrome, which encompasses the combination of sebaceous skin tumours or keratoacanthomas and internal malignancy, due to mutations in DNA mismatch repair genes. Sebaceous neoplasms (SNs) may occur before other malignancies, and may lead to the diagnosis, which allows testing of other family members, cancer surveillance, risk-reducing surgery or prevention therapies. AIM: To evaluate the efficacy of universal immunohistochemistry (IHC) screening of SNs in a service setting...
January 14, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29278695/carcinogenicity-assessment-of-the-hedgehog-pathway-inhibitor-vismodegib-in-tg-rash2-mice-and-sprague-dawley-rats
#6
Jinze Li, Eric Morinello, Thomas Larsen, Denzil Frost, Ivor Caro, Stephen Gould, Lisa Wong, Angela Hendricks, Noel Dybdal, Donna Dambach, Melissa Schutten
Vismodegib (also known as GDC-0449) is a novel small molecule inhibitor of the Hedgehog (Hh) signaling pathway currently approved for the treatment of metastatic or locally advanced basal cell carcinoma (BCC) in humans. Its tumorigenic potential was assessed in dedicated carcinogenicity studies in rasH2 transgenic (Tg.rasH2) mice and Sprague Dawley (SD) rats. Tumorigenicity potential of vismodegib was identified in rats only and was limited to benign hair follicle tumors, including pilomatricomas and keratoacanthomas at exposures of ≥0...
December 23, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29261131/histology-of-non-melanoma-skin-cancers-an-update
#7
REVIEW
Giovanni Paolino, Michele Donati, Dario Didona, Santo Raffaele Mercuri, Carmen Cantisani
Non-melanoma skin cancer (NMSC) is the most frequently diagnosed cancer in humans. Several different non-melanoma skin cancers have been reported in the literature, with several histologic variants that frequently cause important differential diagnoses with other cutaneous tumors basal cell carcinoma (BCC) is the most common malignant skin tumor, with different histologic variants that are associated with a greater or less aggressive behavior and that usually may be confused with other primitive skin tumors...
December 20, 2017: Biomedicines
https://www.readbyqxmd.com/read/29126557/-keratoacanthomas-on-recent-tattoos-two-cases
#8
N Kluger, D Douvin, F Dupuis-Fourdan, J-M Doumecq-Lacoste, V Descamps
BACKGROUND: Increasing numbers of reports of rapidly arising, isolated or eruptive keratoacanthomas (KA) and squamous cell carcinomas (CSC) on the red part of tattoos tend to suggest a non-fortuitous link with the procedure. We report herein two different presentations of KAs on tattoos: one patient with multiple eruptive KAs on sun-exposed areas of a recent red tattoo and another with a solitary lesion on a recent tattoo. We discuss the issues related to the distinction between KAs and CSCs in this particular context...
November 7, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29124377/trendy-tattoos-maybe-a-serious-health-risk
#9
Felix J Paprottka, Nicco Krezdorn, Mustafa Narwan, Marvee Turk, Heiko Sorg, Ernst Magnus Noah, Detlev Hebebrand
BACKGROUND: The literature reports many cases of cutaneous malignancy in the setting of skin tattoos. In this study, we review the reported incidence of and risk factors for tattoo-associated skin cancer. METHODS: A PubMed literature review was performed for all cases of tattoo-associated skin cancer, including squamous cell carcinoma, basal cell carcinoma, malignant melanoma, keratoacanthoma, and other rare skin malignancies (source: PubMed/until June 2017). RESULTS: The authors identified 51 publications and 63 total cases of tattoo-associated skin cancer...
November 9, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29058335/generalized-eruptive-keratoacanthoma-with-vitiligo-followed-by-the-development-of-prurigo-nodularis-a-case-report-and-published-work-review
#10
Qianyue Xu, Congying Li, Jia Zhang, Bo Ling, Hong Yu, Zhirong Yao
Herein, we report a unique case of generalized eruptive keratoacanthoma (GEKA) in a 47-year-old Chinese man presenting with extensive pruritic papules and nodules accompanied by oral lesions. He also had a 2-year history of vitiligo and long-term experience of working outdoors. Biopsies were consistent with keratoacanthoma . Interestingly, prurigo nodularis (PN) was found in histopathology at 1-year follow up. To our knowledge, this is the first report describing a case of GEKA with oral lesions complicated with vitiligo and developed with PN...
October 23, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28948204/use-of-photodynamic-therapy-and-acitretin-in-generalized-eruptive-keratoacanthoma-of-grzybowski
#11
Stephanie Mlacker, Urvashi Kaw, Edward V Maytin
No abstract text is available yet for this article.
September 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28920475/generalised-eruptive-keratoacanthomas-of-grzybowski
#12
Janet Y Li, Daniel J Lewis, Madeleine Duvic
No abstract text is available yet for this article.
September 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28906090/multiple-keratoacanthoma-centrifugum-marginatum-associated-with-juvenile-idiopathic-arthritis-and-persistent-corneal-epithelial-defect-an-unusual-case
#13
Hamid R Jahadi Hosseini, Farhad Handjani, Hamid R Anvari Ardakani, Maryam S Sadati, Mohammad R Khalili, Adel Attarzadeh
We report here a case of a child with multiple keratoacanthoma centrifugum marginatum in association with corneal epithelial defect and juvenile arthritis. Keratoacanthoma is a skin tumor and the patient presented with an uncommon type of it.
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28895378/complete-regression-of-keratoacanthoma-with-topical-tazarotene-gel-0-1-therapeutic-and-pathophysiological-perspectives
#14
Giovanni Paolino, Luca M Muscardin, Michele Donati, Dario Didona, Chiara Panetta, Pietro Donati
No abstract text is available yet for this article.
September 8, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28816744/eruptive-keratoacanthoma-like-discoid-lupus-erythematosus
#15
Corey Georgesen, Cynthia Magro
Hypertrophic discoid lupus erythematosus can resemble keratoacanthoma histomorphologically. We describe a unique case of eruptive keratoacanthomatous scaly papules in a 56-year-old woman with discoid lupus erythematosus. We review the literature and conclude by discussing important histologic features and useful immunostains to consider when attempting to discern the underlying identity and pathogenicity of such lesions.
August 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28796396/development-of-ret-mutant-cutaneous-angiosarcoma-during-braf-inhibitor-therapy
#16
Julia Dai, Christian A Kunder, Emily Y Chu, Edward F Chan, Christine L Egan, Roberto A Novoa
Treatment with BRAF inhibitors may lead to paradoxical mitogen-activated protein kinase (MAPK) pathway activation and accelerated tumorigenesis in cells with preexisting oncogenic hits. This phenomenon manifests clinically in the development of squamous cell carcinomas (SCCs) and keratoacanthomas (KAs) in patients treated with BRAF inhibitors. Cases of extracutaneous malignancies associated with BRAF inhibitors have also been reported. We present a case of a patient who developed a cutaneous angiosarcoma 6 months after initiation of vemurafenib therapy...
August 10, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28776778/eruptive-keratoacanthomas-arising-in-the-setting-of-lichenoid-toxicity-after-programmed-cell-death-1-inhibition-with-nivolumab
#17
LETTER
S I Feldstein, F Patel, L Larsen, E Kim, S Hwang, M A Fung
No abstract text is available yet for this article.
August 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28767028/-the-dutch-college-of-general-practitioners-practice-guideline-suspicious-skin-lesions
#18
Z Damen-van Beek, W Opstelten
- The Dutch College of General Practitioners practice guideline 'Suspicious skin lesions' provides recommendations for diagnosis, treatment and referral for the most common premalignant and malignant skin disorders.- The practice guideline includes a flowchart which starts by looking at the colour and surface of the skin lesion to direct the general practitioner to the most likely diagnosis.- In case of strong suspicion of squamous cell carcinoma, keratoacanthoma or melanoma and in case of basal cell carcinoma or Bowen's disease with high-risk characteristics, the general practitioner will refer the patient to a dermatologist...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28730244/keratoacanthoma-centrifugum-marginatum-an-unusual-clinical-and-histopathological-diagnostic-pitfall
#19
Tiberiu Augustin Georgescu, Ana Maria Oproiu, Mihai George Rădăşan, Adrian Vasile Dumitru, Diana Costache, Oana Maria Pătraşcu, Anca Mihaela Lăzăroiu, Alina Elena Chefani, Maria Sajin, Mariana Costache
Keratoacanthoma centrifugum marginatum (KCM) is a very rare variant of keratoacanthoma characterized by progressive peripheral growth accompanied by central healing. The tumor has the peculiar ability to involute spontaneously. A careful differential diagnostic with other skin carcinomas or hyperkeratotic lesions is required in order to ensure appropriate clinical management. We report a case of KCM in a 62-year-old man presenting with a solitary, large exophytic, sessile tumor located on the ventral side of the right lower leg, which developed over the course of one year from an initial erythematous papule...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28712267/use-of-topical-ephedrine-and-naphazoline-in-the-treatment-of-a-keratoacanthoma-two-case-reports
#20
Maria C Fortuna, Miriam Grimaldi, Valentina Garelli, Giulia Pranteda, Guglielmo Pranteda, Donato DI Nunno, Marta Carlesimo, Alfredo Rossi
No abstract text is available yet for this article.
July 13, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
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