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Keratoacanthoma

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https://www.readbyqxmd.com/read/29126557/-keratoacanthomas-on-recent-tattoos-two-cases
#1
N Kluger, D Douvin, F Dupuis-Fourdan, J-M Doumecq-Lacoste, V Descamps
BACKGROUND: Increasing numbers of reports of rapidly arising, isolated or eruptive keratoacanthomas (KA) and squamous cell carcinomas (CSC) on the red part of tattoos tend to suggest a non-fortuitous link with the procedure. We report herein two different presentations of KAs on tattoos: one patient with multiple eruptive KAs on sun-exposed areas of a recent red tattoo and another with a solitary lesion on a recent tattoo. We discuss the issues related to the distinction between KAs and CSCs in this particular context...
November 7, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29124377/trendy-tattoos-maybe-a-serious-health-risk
#2
Felix J Paprottka, Nicco Krezdorn, Mustafa Narwan, Marvee Turk, Heiko Sorg, Ernst Magnus Noah, Detlev Hebebrand
BACKGROUND: The literature reports many cases of cutaneous malignancy in the setting of skin tattoos. In this study, we review the reported incidence of and risk factors for tattoo-associated skin cancer. METHODS: A PubMed literature review was performed for all cases of tattoo-associated skin cancer, including squamous cell carcinoma, basal cell carcinoma, malignant melanoma, keratoacanthoma, and other rare skin malignancies (source: PubMed/until June 2017). RESULTS: The authors identified 51 publications and 63 total cases of tattoo-associated skin cancer...
November 9, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29058335/generalized-eruptive-keratoacanthoma-with-vitiligo-followed-by-the-development-of-prurigo-nodularis-a-case-report-and-published-work-review
#3
Qianyue Xu, Congying Li, Jia Zhang, Bo Ling, Hong Yu, Zhirong Yao
Herein, we report a unique case of generalized eruptive keratoacanthoma (GEKA) in a 47-year-old Chinese man presenting with extensive pruritic papules and nodules accompanied by oral lesions. He also had a 2-year history of vitiligo and long-term experience of working outdoors. Biopsies were consistent with keratoacanthoma . Interestingly, prurigo nodularis (PN) was found in histopathology at 1-year follow up. To our knowledge, this is the first report describing a case of GEKA with oral lesions complicated with vitiligo and developed with PN...
October 23, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28948204/use-of-photodynamic-therapy-and-acitretin-in-generalized-eruptive-keratoacanthoma-of-grzybowski
#4
Stephanie Mlacker, Urvashi Kaw, Edward V Maytin
No abstract text is available yet for this article.
September 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28920475/generalised-eruptive-keratoacanthomas-of-grzybowski
#5
Janet Y Li, Daniel J Lewis, Madeleine Duvic
No abstract text is available yet for this article.
September 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28906090/multiple-keratoacanthoma-centrifugum-marginatum-associated-with-juvenile-idiopathic-arthritis-and-persistent-corneal-epithelial-defect-an-unusual-case
#6
Hamid R Jahadi Hosseini, Farhad Handjani, Hamid R Anvari Ardakani, Maryam S Sadati, Mohammad R Khalili, Adel Attarzadeh
We report here a case of a child with multiple keratoacanthoma centrifugum marginatum in association with corneal epithelial defect and juvenile arthritis. Keratoacanthoma is a skin tumor and the patient presented with an uncommon type of it.
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28895378/complete-regression-of-keratoacanthoma-with-topical-tazarotene-gel-0-1-therapeutic-and-pathophysiological-perspectives
#7
Giovanni Paolino, Luca M Muscardin, Michele Donati, Dario Didona, Chiara Panetta, Pietro Donati
No abstract text is available yet for this article.
September 8, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28816744/eruptive-keratoacanthoma-like-discoid-lupus-erythematosus
#8
Corey Georgesen, Cynthia Magro
Hypertrophic discoid lupus erythematosus can resemble keratoacanthoma histomorphologically. We describe a unique case of eruptive keratoacanthomatous scaly papules in a 56-year-old woman with discoid lupus erythematosus. We review the literature and conclude by discussing important histologic features and useful immunostains to consider when attempting to discern the underlying identity and pathogenicity of such lesions.
August 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28796396/development-of-ret-mutant-cutaneous-angiosarcoma-during-braf-inhibitor-therapy
#9
Julia Dai, Christian A Kunder, Emily Y Chu, Edward F Chan, Christine L Egan, Roberto A Novoa
Treatment with BRAF inhibitors may lead to paradoxical mitogen-activated protein kinase (MAPK) pathway activation and accelerated tumorigenesis in cells with preexisting oncogenic hits. This phenomenon manifests clinically in the development of squamous cell carcinomas (SCCs) and keratoacanthomas (KAs) in patients treated with BRAF inhibitors. Cases of extracutaneous malignancies associated with BRAF inhibitors have also been reported. We present a case of a patient who developed a cutaneous angiosarcoma 6 months after initiation of vemurafenib therapy...
August 10, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28776778/eruptive-keratoacanthomas-arising-in-the-setting-of-lichenoid-toxicity-after-programmed-cell-death-1-inhibition-with-nivolumab
#10
LETTER
S I Feldstein, F Patel, L Larsen, E Kim, S Hwang, M A Fung
No abstract text is available yet for this article.
August 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28767028/-the-dutch-college-of-general-practitioners-practice-guideline-suspicious-skin-lesions
#11
Z Damen-van Beek, W Opstelten
- The Dutch College of General Practitioners practice guideline 'Suspicious skin lesions' provides recommendations for diagnosis, treatment and referral for the most common premalignant and malignant skin disorders.- The practice guideline includes a flowchart which starts by looking at the colour and surface of the skin lesion to direct the general practitioner to the most likely diagnosis.- In case of strong suspicion of squamous cell carcinoma, keratoacanthoma or melanoma and in case of basal cell carcinoma or Bowen's disease with high-risk characteristics, the general practitioner will refer the patient to a dermatologist...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28730244/keratoacanthoma-centrifugum-marginatum-an-unusual-clinical-and-histopathological-diagnostic-pitfall
#12
Tiberiu Augustin Georgescu, Ana Maria Oproiu, Mihai George Rădăşan, Adrian Vasile Dumitru, Diana Costache, Oana Maria Pătraşcu, Anca Mihaela Lăzăroiu, Alina Elena Chefani, Maria Sajin, Mariana Costache
Keratoacanthoma centrifugum marginatum (KCM) is a very rare variant of keratoacanthoma characterized by progressive peripheral growth accompanied by central healing. The tumor has the peculiar ability to involute spontaneously. A careful differential diagnostic with other skin carcinomas or hyperkeratotic lesions is required in order to ensure appropriate clinical management. We report a case of KCM in a 62-year-old man presenting with a solitary, large exophytic, sessile tumor located on the ventral side of the right lower leg, which developed over the course of one year from an initial erythematous papule...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28712267/use-of-topical-ephedrine-and-naphazoline-in-the-treatment-of-a-keratoacanthoma-two-case-reports
#13
Maria C Fortuna, Miriam Grimaldi, Valentina Garelli, Giulia Pranteda, Guglielmo Pranteda, Donato DI Nunno, Marta Carlesimo, Alfredo Rossi
No abstract text is available yet for this article.
July 13, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28709693/squamous-proliferations-on-the-legs-of-women-qualitative-examination-of-histopathology-tp53-sequencing-and-implications-for-diagnosis-in-a-series-of-30-cases
#14
Christine J Ko, Earl J Glusac, Jennifer M McNiff, Nemanja Rodic, David J Leffell
BACKGROUND: Women with multiple squamous cell carcinomas (SCCs) of the legs have a striking clinical phenotype. Numerous tumors can develop in a short period of time. OBJECTIVE: Because histopathologic findings can vary in women with multiple SCC lesions, from keratoacanthoma-like to well-differentiated SCC, we hypothesized that TP53 variants might shed light on the appropriate classification. METHODS: We sequenced TP53 in 30 SCCs from 6 women who had multiple SCCs on their legs during a 21-month time frame...
July 11, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28705282/fine-and-benign-until-it-becomes-malignant-the-enigmatic-keratoacanthoma
#15
Ann M John, Heather Holahan, Parmvir Singh, Hee J Kim, Marc Z Handler, W Clark Lambert
No abstract text is available yet for this article.
2017: Skinmed
https://www.readbyqxmd.com/read/28661073/squamous-neoplasms-arising-within-tattoos-clinical-presentation-histopathology-and-management
#16
REVIEW
A L Junqueira, K A Wanat, R S Farah
Tattooing, which involves the placement of ink into the skin, is an ancient decorative technique that has remained popular in modern society. Tattoos have long been known to cause cutaneous reactions, which include the emergence of neoplasms such as keratoacanthoma (KA) and squamous cell carcinoma (SCC) in tattooed areas of the skin. We review the clinical presentations, histology and treatment options for squamous neoplasms, primarily KA and SCC, arising in tattoos.
August 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28628690/case-report-of-multiple-keratoacanthomas-and-squamous-cell-carcinomas-in-a-patient-receiving-pembrolizumab
#17
Soham Chaudhari, Argentina Leon, Ethan Levin, Isaac Neuhaus, Wilson Liao
<p>PD-1 is expressed on antigen-stimulated T cells and induces a downstream signaling pathway that works by negative feedback to inhibit T cell proliferation, cytokine release, and cytotoxicity. PD-1 antibodies increase tumor cell killing peripherally and have a role in advanced melanoma treatment. We describe a case of an 84 year old female with stage 4 metastatic melanoma in a trial of the PD-1 inhibitor pembrolizumab who developed multiple keratoacanthomas after several months of treatment. While keratoacanthomas have been reported in patients taking BRAF inhibitors, no such reports exist for those on pembrolizumab, making this the first case report to point out this association for further investigative studies...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28611627/panniculitis-associated-with-mek-inhibitor-therapy-an-uncommon-adverse-effect
#18
Miruna Negulescu, Florian Deilhes, Vincent Sibaud, Emilie Tournier, Laurence Lamant, Serge Boulinguez, Nicolas Meyer
The combination of MEK inhibitor (cobimetinib, trametinib) and BRAF inhibitor (vemurafenib, dabrafenib) is now the first-line treatment in patients with BRAF V600-mutated metastatic melanoma. This association reduces cutaneous adverse events induced by BRAF inhibitors alone, including photosensitivity, hand-foot syndrome, hyperkeratosis, alopecia, skin papillomas, keratoacanthomas, and squamous-cell carcinomas. While panniculitis has exceptionally been reported with BRAF inhibitors, this rare side effect has never been described with the use of MEK inhibitors...
January 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28584672/keratoacanthoma-of-the-nasal-septum-secondary-to-ranibizumab-use
#19
Jason E Cohn, Hilary M Caruso Sales, Giang Huong Nguyen, Harvey Spector, Kenneth Briskin
Keratoacanthoma (KA) is a benign epithelial tumor that typically presents as a firm, cone-shaped, flesh-colored nodule with a central horn-filled crater. KA is considered to be a low-grade variant of squamous cell carcinoma (SCC). We report a rare case of a 72-year-old male who presented with a KA involving the nasal septum, possibly related to ranibizumab use. A flesh-colored lesion on the right anterior nasal septum lesion was visualized on examination. Histologic examination revealed a well-circumscribed, dome-shaped central crater filled with keratin, well-differentiated squamous epithelium with ground-glass cytoplasm with pushing margins, and intraepithelial microabscesses establishing the diagnosis of KA...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28543888/multiple-keratoacanthoma-centrifugum-marginatum-in-a-young-boy-and-review-of-the-literature
#20
S Dogra, K Vinay, U N Saikia, D De, S Handa
No abstract text is available yet for this article.
May 24, 2017: Clinical and Experimental Dermatology
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