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Keratoacanthoma

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https://www.readbyqxmd.com/read/28146464/keratoacanthoma%C3%A2-like-cutaneous-metastases-as-the-first-presentation-of-lung-cancer
#1
Martyna Sławińska, Michał Sobjanek, Wojciech Biernat, Roman Nowicki
No abstract text is available yet for this article.
January 31, 2017: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/28101021/late-onset-multiple-self-healing-squamous-epithelioma-ferguson-smith-recurrence-induced-by-radiotherapy
#2
Laurence Feldmeyer, Ildiko Szeverényi, Michèle Mandallaz, E Birgit Lane, Daniel Hohl
We report the case of a woman in her 60s with confirmed multiple self-healing squamous epitheliomas (MSSE) Ferguson-Smith. After recurrences following surgery and radiotherapy, the patient was successfully treated with minimal surgical intervention combined with intralesional injections of triamcinolone acetate. The histological comparison between mature and regressed keratoacanthomas (KA) revealed an increased inflammatory infiltrate with numerous plasmacytoid dendritic cells in the regressed KA in comparison to the mature one, speaking in favor of an inflammation-mediated regression process...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28099546/multiple-keratoacanthomas-occurring-in-surgical-margins-and-de-novo-treated-with-intralesional-methotrexate
#3
Vindhya L Veerula, Navid Ezra, Mouhammad Aouthmany, Thomas A Graham, Stephen E Wolverton, Ally-Khan Somani
Keratoacanthomas (KAs) are common skin lesions known for their rapid growth and spontaneous regression. Keratoacanthomas also can occur in sites of prior trauma, such as surgical scars. We report a case of multiple KAs occurring in the site of trauma from a prior surgery and de novo as well as the response to treatment with intralesional methotrexate (MTX).
December 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28095561/self-resolving-eruptive-keratoacanthomas-after-full-field-erbium-laser-resurfacing
#4
Eileen L Axibal, Julia D Kreger, Michael E Contreras, Joel L Cohen
Keratoacanthoma (KA) is a subtype of squamous cell carcinoma whose development has been linked to excessive sun exposure, immunosuppression, and trauma. Given the rapidly expanding therapeutic armamentarium for anti-aging modalities in dermatology, reports of KA secondary to invasive cosmetic procedures are on the rise. We present a case of eruptive KAs after full- eld ablative Erbium:YAG 2940 nm laser resurfacing of the face that resolved with minimal intervention. This case demonstrates the potential for a rare yet signi cant laser complication that may warrant discussion during the consenting process...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28087033/keratoacanthoma-like-dermatofibroma-a-dermoscopic-challenge
#5
Vincenzo Piccolo, Teresa Russo, Markus Danielsson, Daniela Russo, Andres Mauricio Lòpez Muñoz, Massimo Mascolo, Giuseppe Argenziano
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28027254/evidence-based-medicine-cutaneous-facial-malignancies-nonmelanoma-skin-cancer
#6
Karen L Connolly, Kishwer S Nehal, Joseph J Disa
LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Identify clinical features of nonmelanoma skin cancer; 2. Distinguish low-risk versus high-risk basal cell carcinoma and squamous cell carcinoma; 3. Define appropriate management based on current guidelines for various types of basal cell and squamous cell carcinoma. SUMMARY: Skin malignancies are the most prevalent cancers, and plastic surgeons are often the primary physicians engaged in diagnosis and management of these lesions...
January 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28007674/the-current-role-of-in-vivo-reflectance-confocal-microscopy-within-the-continuum-of-actinic-keratosis-and-squamous-cell-carcinoma-a-systematic-review
#7
Kim P Nguyen, Malou Peppelman, Lisa Hoogedoorn, Piet E J Van Erp, Marie-Jeanne P Gerritsen
BACKGROUND: Clinical differentiation between actinic keratosis (AK), squamous cell carcinoma (SCC) in situ, and invasive SCC and its variants may be difficult. Reflectance confocal microscopy (RCM) is a non-invasive technique for in vivo skin imaging. OBJECTIVES: To explicate the diagnostic and monitoring use of RCM within the spectrum of AK and SCC, and evaluate the accuracy of RCM for these diagnoses relative to histopathology. MATERIALS & METHODS: A systematic literature search was performed in PubMed, EMBASE, the Cochrane Library, and Web of Science databases...
December 1, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27999416/dermal-delivery-of-constructs-encoding-cre-recombinase-to-induce-skin-tumors-in-pten-loxp-loxp-braf-ca-mice
#8
Marcel A Deken, Ji-Ying Song, Jules Gadiot, Adriaan D Bins, Paula Kroon, Inge Verbrugge, Christian U Blank
Current genetically-engineered mouse melanoma models are often based on Tyr::CreER(T2)-controlled MAPK pathway activation by the BRAF(V600E) mutation and PI3K pathway activation by loss of PTEN. The major drawback of these models is the occurrence of spontaneous tumors caused by leakiness of the Tyr::CreER(T2) system, hampering long-term experiments. To address this problem, we investigated several approaches to optimally provide local delivery of Cre recombinase, including injection of lentiviral particles, DNA tattoo administration and particle-mediated gene transfer, to induce melanomas in Pten(LoxP/LoxP);Braf(CA/+) mice lacking the Tyr::CreER(T2) allele...
December 20, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27993945/human-polyomavirus-dna-detection-in-keratoacanthoma-and-spitz-naevus-no-evidence-for-a-causal-role
#9
Linnea Haeggblom, Joar Franzén, Anders Näsman
Keratoacanthomas (KA) and Spitz naevus (SN) are both lesions with unknown aetiology; therefore, the possibility of a viral involvement, more specifically the involvement of human polyomaviruses (HPyV), was investigated. In total, 22 cases of KA and 25 cases of SN were tested for the presence of HPyVs. DNA was extracted and amplified by multiplex PCR and thereafter tested with a multiplex bead-based assay for HPyVs (BKPyV, JCPyV, KIPyV, WUPyV, MCPyV, TSPyV, HPyV6, 7 and 9) and two primate viruses (SV40 and LPyV)...
December 19, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27922892/galectin-3-expression-in-benign-and-malignant-skin-diseases-with-epidermal-hyperplasia
#10
Ze-Xin Jiang, Guo-Zhen Tan, Zhen-Rui Shi, Yu-Ping Zhang, Yan-Fang Han, Liangchun Wang
Galectin-3 has been suggested relative to tumor genesis, progression, and metastasis in basal cell carcinoma and squamous cell carcinoma that are the most common skin cancers characterized by malignant epidermal proliferation. In this study, we evaluated galectin-3 expression in seborrheic keratosis, keratoacanthoma, and infectious diseases including verruca vulgaris, condyloma acuminatum, and chromoblastomycosis that are pathologically featured by benign epidermal proliferation. Galectin-3 expression was shown by immunohistochemical staining and quantified using the Image Pro Plus V6...
November 7, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27822110/the-danish-nonmelanoma-skin-cancer-dermatology-database
#11
REVIEW
Anna Lei Lamberg, Henrik Sølvsten, Ulrikke Lei, Gabrielle Randskov Vinding, Ida Marie Stender, Gregor Borut Ernst Jemec, Tine Vestergaard, Henrik Thormann, Merete Hædersdal, Tomas Norman Dam, Anne Braae Olesen
AIM OF DATABASE: The Danish Nonmelanoma Skin Cancer Dermatology Database was established in 2008. The aim of this database was to collect data on nonmelanoma skin cancer (NMSC) treatment and improve its treatment in Denmark. NMSC is the most common malignancy in the western countries and represents a significant challenge in terms of public health management and health care costs. However, high-quality epidemiological and treatment data on NMSC are sparse. STUDY POPULATION: The NMSC database includes patients with the following skin tumors: basal cell carcinoma (BCC), squamous cell carcinoma, Bowen's disease, and keratoacanthoma diagnosed by the participating office-based dermatologists in Denmark...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27788211/aberrant-dna-methylation-in-keratoacanthoma
#12
Yoshimasa Nobeyama, Hidemi Nakagawa
BACKGROUND: Keratoacanthoma (KA) is a self-limiting epidermal tumor for which histopathological examination sometimes suggests malignancy. Based on inconsistent clinical views, KA can be regarded as both a benign tumor and a variant of squamous cell carcinoma (SCC). Aberrant DNA methylation frequently occurs in malignant tumors but it scarcely occurs in benign tumors. Whether aberrant methylation occurs in KA has not been previously examined. OBJECTIVE: The aim is to elucidate whether aberrant methylation of CpG islands (CGI) containing a high density of cytosine-guanine dinucleotide (CpG) sites occurs in KA...
2016: PloS One
https://www.readbyqxmd.com/read/27739125/toxic-epidermal-necrolysis-induced-by-vemurafenib-after-nivolumab-failure
#13
M Arenbergerova, I Mrazova, J Horazdovsky, E Sticova, A Fialova, P Arenberger
Vemurafenib is a selective inhibitor of the BRAF-kinase approved for the treatment of metastatic melanoma harboring BRAF mutation. Skin toxicity, including maculopapular exanthema, photosensitivity and keratoacanthoma, are the most common treatment-related adverse events of vemurafenib, affecting more than 90% of patients (1,2). It rarely presents with intense severity, with less than 1% of grade-4 toxicities reported in clinical trials (3,4). This article is protected by copyright. All rights reserved.
October 14, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27717016/an-acneiform-eruption-exhibiting-locus-minoris-resistentiae-after-whole-brain-radiation-and-vemurafenib-therapy
#14
C Noell, C Chen, R Sells, A Mikailov, D Kroshinsky
No abstract text is available yet for this article.
September 9, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27688833/economic-burden-of-toxicities-associated-with-treating-metastatic-melanoma-in-the-united-states
#15
S Pinar Bilir, Qiufei Ma, Zhongyun Zhao, Elizabeth Wehler, Julie Munakata, Beth Barber
BACKGROUND: Little has been reported on the costs of managing the adverse events (AEs) associated with current therapies for patients with regional or distant metastatic melanoma. OBJECTIVES: To identify treatment-related AEs in patients with metastatic melanoma and to estimate the associated costs of treating these AEs in the United States. METHODS: A cost-estimation study for AEs associated with treatment of metastatic melanoma was conducted from 2012 to 2013 by identifying grades 3 and 4 AEs through the use of a comprehensive search of drug labels and English-language, published phase 2/3 studies in PubMed, conference abstracts, and the National Comprehensive Cancer Network guidelines...
June 2016: American Health & Drug Benefits
https://www.readbyqxmd.com/read/27684856/successful-treatment-of-cutaneous-squamous-cell-carcinoma-with-intralesional-cryosurgery-case-report
#16
Chaw-Ning Lee, Shin-Chen Pan, Julia Yu-Yun Lee, Tak-Wah Wong
BACKGROUND: Wide excision or Mohs surgery is the standard treatment of skin squamous cell carcinoma (SCC). Superficial SCC or tumor smaller than 1 cm has been treated successfully with open spray cryosurgery. Larger tumor may not be as effective because tissue destruction is usually superficial. Intralesional cryosurgery (IC) may provide a deeper and better cell killing effect in larger tumors. We investigated the safety and efficacy of treating nodular SCC in 4 patients with IC. METHODS: Four patients with nodular SCC/keratoacanthoma (tumor size, 1-2...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27624900/prospective-case-series-of-cutaneous-adverse-effects-associated-with-dabrafenib-and-trametinib
#17
Jean-Philip Lacroix, Beatrice Wang
BACKGROUND: Dabrafenib, a novel selective small-molecule inhibitor of BRAF, has been shown to increase overall survival in patients with unresectable metastatic melanoma harboring the BRAF V600E mutation. The development of resistance has led to combination therapy with selective MEK inhibitor trametinib. Compared with vemurafenib, dabrafenib is a more recent BRAF inhibitor approved by the Food and Drug Administration in May 2013 for metastatic melanoma; fewer data are available in the current literature regarding cutaneous toxicity...
September 13, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27570202/basosquamous-carcinoma-dermoscopic-clues-to-diagnosis
#18
Bengu Nisa Akay, Secil Saral, Aylin O Heper, Cengizhan Erdem, Cliff Rosendahl
Basosquamous carcinoma (BSC) is a rare skin cancer which has areas of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) and a transition zone between them. However, dermoscopic features of BSC are not well described in the published work, except one study. The aim of the present study was to better identify and clarify the dermoscopic findings of BSC in the largest group of patients in the published work and to describe its dermoscopic features according to histopathologically BCC-dominant, SCC-dominant and intermediate categories...
August 29, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27559516/a-rare-case-of-multiple-keratoacanthomas-treated-with-oral-acitretin-and-intralesional-methotrexate
#19
Sweta Hasmukh Rambhia, Kinjal Deepak Rambhia, Amit Gulati
No abstract text is available yet for this article.
July 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27537773/melanoma-masquerading-as-nonmelanocytic-lesions
#20
Audrey Detrixhe, Florence Libon, Marion Mansuy, Nazli Nikkels-Tassoudji, Andrée Rorive, Jorge E Arrese, Pascale Quatresooz, Marie-Annick Reginster, Arjen F Nikkels
Increased awareness among dermatologists as well as the development of dermoscopy and sequential dermoscopy have contributed significantly toward an increase in the diagnostic accuracy of pigmented melanoma and even of amelanotic melanoma. However, the dermatologist's nightmare is the small group of melanomas that present as common skin diseases, often associated with a significant delay in diagnosis and hence a poor prognosis. The study was carried out to prospectively assess the number of melanomas lacking any clinical suspicion of melanoma and to describe their clinical and histological features over a 6-year observation period in an University Tertiary Skin Cancer Center...
August 17, 2016: Melanoma Research
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