Pang Yao, Andri Iona, Alfred Pozarickij, Saredo Said, Neil Wright, Kuang Lin, Iona Millwood, Hannah Fry, Christiana Kartsonaki, Mohsen Mazidi, Yiping Chen, Fiona Bragg, Bowen Liu, Ling Yang, Junxi Liu, Daniel Avery, Dan Schmidt, Dianjianyi Sun, Pei Pei, Jun Lv, Canqing Yu, Michael Hill, Derrick Bennett, Robin Walters, Liming Li, Robert Clarke, Huaidong Du, Zhengming Chen
OBJECTIVE: Integrated analyses of plasma proteomics and genetic data in prospective studies can help assess the causal relevance of proteins, improve risk prediction, and discover novel protein drug targets for type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We measured plasma levels of 2,923 proteins using Olink Explore among ∼2,000 randomly selected participants from China Kadoorie Biobank (CKB) without prior diabetes at baseline. Cox regression assessed associations of individual protein with incident T2D (n = 92 cases)...
April 16, 2024: Diabetes Care