Y Sofer, Y Nash, E Osher, O Fursht, G Goldsmith, L Nahary, S Shaklai, K M Tordjman, M Serebro, E B Touati, M Yacobi Bach, Y Marcus, B Tal, J Sack, G Shefer, M Margaliot, N Landis, I Goldiner, W Abu Ahmad, N Stern, I Benhar, D Frenkel
Metabolic syndrome (MS) is comprised of a cluster of abnormalities in glucose, lipid, and vascular homeostasis, which is most commonly linked to abdominal obesity. MS heralds increased risk for development of diabetes and is linked to impairment in insulin signaling. Insulin-degrading enzyme (IDE) is one of the mechanisms through which insulin blood levels are maintained. It has been previously suggested that controlling IDE levels could provide yet another potential therapeutic approach in diabetes. Here we aim to investigate whether changes in serum IDE levels correlate with the severity of MS...
February 2021: Endocrine