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https://www.readbyqxmd.com/read/29924722/interaction-of-volatile-organic-compounds-and-underlying-liver-disease-a-new-paradigm-for-risk
#1
Anna L Lang, Juliane I Beier
Occupational and environmental exposures to industrial chemicals are known to cause hepatotoxicity and liver injury, in humans and in animal models. Historically, research has focused on severe acute liver injury (e.g., fulminant liver failure) or endstage diseases (e.g., cirrhosis and HCC). However, it has become recently recognized that toxicants can cause more subtle changes to the liver. For example, toxicant-associated steatohepatitis (TASH), characterized by hepatic steatosis, and inflammation, was recently recognized in an occupational cohort exposed to vinyl chloride...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29924135/exenatide-ameliorates-hepatic-steatosis-and-attenuates-fat-mass-and-fto-gene-expression-through-pi3k-signaling-pathway-in-nonalcoholic-fatty-liver-disease
#2
Shan Li, Xiaoman Wang, Jielei Zhang, Jingyi Li, Xiaogang Liu, Yuanyuan Ma, Chao Han, Lixia Zhang, Lili Zheng
Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist antidiabetic drug, has the capacity to overcome insulin resistance and attenuate hepatic steatosis but the specific underlying mechanism is unclear. This study was designed to investigate the underlying molecular mechanisms of exenatide therapy on NAFLD. We used in vivo and in vitro techniques to investigate the protective effects of exenatide on fatty liver via fat mass and obesity associated gene (FTO) in a high-fat (HF) diet-induced NAFLD animal model and related cell culture model...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29923211/beneficial-effect-of-apple-vinegar-on-reproductive-parameters-in-male-rat-model-of-nonalcoholic-fatty-liver-disease
#3
Fahimeh Mohammadghasemi, Masumeh Abbasi, Kamran Rudkhaneei, Monireh Aghajany-Nasab
Nonalcoholic fatty liver disease (NAFLD) is associated with low testosterone levels in serum. The aim of this study was to evaluate the effect of apple vinegar on fertility indices in a rat model of NAFLD. To study this effect, 32 adult male rats were divided into four groups: A-normal diet, B-high-fat diet (HFD), C-apple vinegar and D-HFD plus apple vinegar. At the end of the week 22, the Lee index, serum lipid profiles, liver enzymes, glucose and total antioxidant levels (TAC) in serum were determined. In addition, liver and testis tissue homogenate, histopathology, serum testosterone and sperm parameters were measured and HOMA-IR calculated...
June 19, 2018: Andrologia
https://www.readbyqxmd.com/read/29922758/100-sustained-virological-response-and-fibrosis-improvement-in-real-life-use-of-direct-acting-antivirals-in-genotype-1b-recurrent-hepatitis-c-following-liver-transplantation
#4
Speranta Iacob, Razvan Cerban, Corina Pietrareanu, Carmen Ester, Razvan Iacob, Cristian Gheorghe, Irinel Popescu, Liana Gheorghe
BACKGROUND: Nowadays, interferon-free therapy using new direct-acting antivirals (DAA) has dramatically increased the cure rate across different HCV-infected patient populations, including groups traditionally viewed as difficult-to-treat (patients with co-infections, cirrhosis and liver transplant - LT recipients) with marked improvement in safety and tolerability. AIM: To present our experience with DAA therapy in LT recipients, as well as to compare pre- and post-treatment liver stiffness (LS) and noninvasive fibrosis scores...
June 2018: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/29922168/co-expression-analysis-of-sirtuins-and-related-metabolic-biomarkers-in-juveniles-of-gilthead-sea-bream-sparus-aurata-with-differences-in-growth-performance
#5
Paula Simó-Mirabet, Erick Perera, Josep A Calduch-Giner, Juan M Afonso, Jaume Pérez-Sánchez
Sirtuins (SIRTs) represent a conserved protein family of deacetylases that act as master regulators of metabolism, but little is known about their roles in fish and livestock animals in general. The present study aimed to assess the value of SIRTs for the metabolic phenotyping of fish by assessing their co-expression with a wide-representation of markers of energy and lipid metabolism and intestinal function and health in two genetically different gilthead sea bream strains with differences in growth performance...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29920701/sarcopenia-is-associated-with-the-risk-of-significant-liver-fibrosis-in-metabolically-unhealthy-subjects-with-chronic-hepatitis-b
#6
E Han, Y-H Lee, B K Kim, J Y Park, D Y Kim, S H Ahn, B-W Lee, E S Kang, B-S Cha, K-H Han, S U Kim
BACKGROUND: Sarcopenia is significantly associated with the degree of liver fibrosis. This study investigated the influence of sarcopenia on liver fibrosis in individuals with chronic hepatitis B. METHODS: Data from the Korean National Health and Nutrition Examination Surveys 2008-2011 were analysed. The sarcopenia index (total appendicular skeletal muscle mass [kg]/body mass index [kg/m2 ]) was calculated using dual-energy X-ray absorptiometry. Sarcopenia was defined as the lowest quintile sarcopenia index value (cut-offs: 0...
June 19, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29917092/systematic-review-and-meta-analysis-of-controlled-intervention-studies-on-the-effectiveness-of-long-chain-omega-3-fatty-acids-in-patients-with-nonalcoholic-fatty-liver-disease
#7
Kathy Musa-Veloso, Carolina Venditti, Han Youl Lee, Maryse Darch, Seth Floyd, Spencer West, Ryan Simon
Context: Treatment options for nonalcoholic fatty liver disease (NAFLD) are needed. Objective: The aim of this review was to systematically assess the effects of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs), particularly eicosapentaenoic acid and docosahexaenoic acid, on liver-related and metabolic outcomes in adult and pediatric patients with NAFLD. Data Sources: The online information service ProQuest Dialog was used to search 8 literature databases...
June 15, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29915139/non-invasive-assessment-of-liver-disease-in-rats-using-multiparametric-magnetic-resonance-imaging-a-feasibility-study
#8
Anna M Hoy, Natasha McDonald, Ross J Lennen, Matteo Milanesi, Amy H Herlihy, Timothy J Kendall, William Mungall, Michael Gyngell, Rajarshi Banerjee, Robert L Janiczek, Philip S Murphy, Maurits A Jansen, Jonathan A Fallowfield
Non-invasive quantitation of liver disease using multiparametric MRI could refine clinical care pathways, trial design and preclinical drug development. The aim of the study was to evaluate the use of multiparametric MRI in experimental models of liver disease. Liver injury was induced in rats using 4 or 12 weeks carbon tetrachloride (CCl4 ) intoxication and 4 or 8 weeks methionine and choline deficient (MCD) diet. Liver MRI was performed using a 7.0 Tesla small animal scanner at baseline and specified timepoints after liver injury...
June 18, 2018: Biology Open
https://www.readbyqxmd.com/read/29914094/-ganoderma-lucidum-ameliorates-non-alcoholic-steatosis-by-upregulating-energy-metabolizing-enzymes-in-the-liver
#9
Soonwoong Jung, Hyeonwi Son, Chung Eun Hwang, Kye Man Cho, Sang Won Park, Hyun Joon Kim
Non-alcoholic steatosis is a common health problem worldwide due to altered food habits and life styles, and it is intimately linked with various metabolic disorders. In the present study, we investigated the molecular mechanism of Ganoderma lucidum (GL) against the development of non-alcoholic steatosis using in vivo and in vitro settings. C57BL/6 mice fed with normal diet (ND) or high fat diet (HFD) were administered GL extract or vehicle for 16 weeks. HFD feeding increased serum alanine aminotransferase level and hepatic lipid droplet, but these increases were significantly attenuated by GL...
June 15, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29913455/grape-leucoanthocyanidin-protects-liver-tissue-in-albino-rabbits-with-nonalcoholic-hepatic-steatosis
#10
Reginaldo Franklin, Rodrigo Freitas Monte Bispo, Célio Fernando Sousa-Rodrigues, Lucas Alves Sarmento Pires, Albino Fonseca, Marcio Antonio Babinski
Nonalcoholic fatty liver disease (NAFLD) is a common ailment. It is usually found in association with diabetes or obesity. There are no approved drugs to treat this condition. The study of flavonoid consumption has increased over the decades due to their antioxidative properties, although the literature is scarce when it comes to their effects in liver tissue. The purpose of this study was to evaluate the role of leucoanthocyanidin in nonalcoholic hepatic steatosis. Thirty male albino rabbits were divided in 3 groups...
June 18, 2018: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29913275/rates-and-factors-associated-with-placebo-response-in-trials-of-pharmacotherapies-for-nonalcoholic-steatohepatitis-systematic-review-and-meta-analysis
#11
REVIEW
Ma Ai Thanda Han, Osama Altayar, Shadi Hamdeh, Varun Takyar, Yaron Rotman, Ohad Etzion, Eric Lefebvre, Rifaat Safadi, Vlad Ratziu, Larry J Prokop, Mohammad Hassan Murad, Mazen Noureddin
BACKGROUND & AIMS: Understanding the extent of the placebo effect in randomized controlled trials of studying nonalcoholic steatohepatitis (NASH) is important for optimal trial design, including sample size calculations and treatment endpoint definition. METHODS: We performed a systematic review and meta-analysis of the placebo groups from randomized controlled trials of adults with NASH that provided histological and/or magnetic resonance image-based measurements of intrahepatic triglyceride...
June 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29911961/liver-donation-after-brain-death-following-intentional-ingestion-of-99-e-cigarette-liquid-nicotine-10-ml
#12
Jinwoong Lee, Yeonho You, Jung Soo Park, Jin Hong Min, Insool Yoo, Wonjoon Jeong, Yongchul Cho, Seung Ryu, Seungwhan Kim, Sung Uk Cho, Se Kwang Oh, Junwan Lee, Hong Joon Ahn, Sang Min Jung
Incidences of brain death due to nicotine overdose by e-cigarettes have been increasing. In such cases, liver donation has been not reported because of the secondary damage to the liver due to metabolism of large amounts of nicotine. However, kidneys have been considered acceptable for transplant. Here, we present a successful case of liver transplant from a brain-dead donor due to intentional nicotine ingestion who did not have extensive steatosis. To the best of our knowledge, this is the first report of such a case...
June 18, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29908922/serum-angiopoietin-like-peptide-4-levels-in-patients-with-hepatic-steatosis
#13
Özgür Altun, Okan Dikker, Yücel Arman, Bilal Ugurlukisi, Orkide Kutlu, Eylem Ozgun Cil, Sengul Aydin Yoldemir, Murat Akarsu, Mustafa Ozcan, Semih Kalyon, Neslihan Ozsoy, Tufan Tükek
OBJECTIVES: Angiopoietin-like peptide 4 (ANGPTL-4) plays an important role in lipid metabolism by inhibiting the enzyme lipoprotein lipase. This effect of ANGPTL-4 results in suppression of the release of plasma triglyceride-derived fatty acids. Increase in fatty acid levels entering to the liver and abnormalities in their secretion is one of the main mechanisms in pathogenesis of hepatic steatosis. In this study, we aimed to investigate the role of ANGPTL-4 in pathogenesis of hepatic steatosis by determining its levels in patients with fatty liver disease...
June 13, 2018: Cytokine
https://www.readbyqxmd.com/read/29908359/statin-therapy-does-not-reduce-liver-fat-scores-in-patients-receiving-antiretroviral-therapy-for-hiv-infection
#14
Vanessa El Kamari, Corrilynn O Hileman, Pierre M Gholam, Manjusha Kulkarni, Nicholas Funderburg, Grace A McComsey
BACKGROUND & AIMS: Therapies are needed to limit progression of fatty liver diseases in patients with HIV infection. We analyzed data from a prospective study of the effects of rosuvastatin (a statin) on hepatic steatosis in HIV-positive adults. METHODS: We performed secondary analysis of data from a double-blind trial of adult patients with HIV infection (78% male; 68% African American; mean age, 46 years; body mass index, 29 kg/m2 ; HIV1 RNA<1000 copies/mL; LDL-cholesterol <130 mg/dL) receiving antiretroviral therapy...
June 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29907965/the-genetic-architecture-of-diet-induced-hepatic-fibrosis-in-mice
#15
Simon T Hui, Zeyneb Kurt, Iina Tuominen, Frode Norheim, Richard C Davis, Calvin Pan, Darwin L Dirks, Clara E Magyar, Samuel W French, Karthickeyan Chella Krishnan, Simon Sabir, Francisco Campos-Pérez, Nahum Méndez-Sánchez, Luis Macías-Kauffer, Paola León-Mimila, Samuel Canizales-Quinteros, Xia Yang, Simon W Beaven, Adriana Huertas-Vazquez, Aldons J Lusis
We report the genetic analysis of a "humanized" hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis. Mice carrying transgenes for human APOE*3-Leiden and CETP and fed a "Western" diet were studied on the genetic backgrounds of over 100 inbred mouse strains. The mice developed hepatic inflammation and fibrosis that was highly dependent on genetic background, with vast differences in the degree of fibrosis. Histological analysis showed features characteristic of human NASH, including macrovesicular steatosis, hepatocellular ballooning, inflammatory foci and pericellular collagen deposition...
June 16, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29907829/multiparametric-magnetic-resonance-imaging-for-quantitation-of-liver-disease-a-two-centre-cross-sectional-observational-study
#16
Natasha McDonald, Peter J Eddowes, James Hodson, Scott I K Semple, Nigel P Davies, Catherine J Kelly, Stella Kin, Miranda Phillips, Amy H Herlihy, Timothy J Kendall, Rachel M Brown, Desley A H Neil, Stefan G Hübscher, Gideon M Hirschfield, Jonathan A Fallowfield
LiverMultiScan is an emerging diagnostic tool using multiparametric MRI to quantify liver disease. In a two-centre prospective validation study, 161 consecutive adult patients who had clinically-indicated liver biopsies underwent contemporaneous non-contrast multiparametric MRI at 3.0 tesla (proton density fat fraction (PDFF), T1 and T2* mapping), transient elastography (TE) and Enhanced Liver Fibrosis (ELF) test. Non-invasive liver tests were correlated with gold standard histothological measures. Reproducibility of LiverMultiScan was investigated in 22 healthy volunteers...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29902644/high-prevalence-of-hepatic-fibrosis-measured-by-elastography-in-a-population-based-study-of-mexican-americans
#17
Gordon P Watt, Miryoung Lee, Jen-Jung Pan, Michael B Fallon, Rohit Loomba, Laura Beretta, Joseph B McCormick, Susan P Fisher-Hoch
BACKGROUND & AIMS: Hepatic fibrosis is a primary risk factor for cirrhosis and hepatocellular carcinoma, which affect a disproportionate number of Hispanics in the United States. We aimed to determine the prevalence of significant fibrosis, measured by point shear-wave elastography (pSWE), and determine characteristics of hepatic fibrosis and simple steatosis in a population-based study of Mexican American Hispanics in south Texas. METHODS: Liver stiffness was measured by pSWE, performed by 2 separate operators, for 406 participants in the Cameron County Hispanic Cohort from 2015 through 2017...
June 11, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29902522/role-of-camp-and-phosphodiesterase-signaling-in-liver-health-and-disease
#18
Banrida Wahlang, Craig McClain, Shirish Barve, Leila Gobejishvili
Liver disease is a significant health problem worldwide with mortality reaching around 2 million deaths a year. Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are the major causes of chronic liver disease. Pathologically, NAFLD and ALD share similar patterns of hepatic disorders ranging from simple steatosis to steatohepatitis, fibrosis and cirrhosis. It is becoming increasingly important to identify new pharmacological targets, given that there is no FDA-approved therapy yet for either NAFLD or ALD...
June 11, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29902065/mesenteric-adipose-tissue-contributes-to-intestinal-barrier-integrity-and-protects-against-non-alcoholic-fatty-liver-disease-in-mice
#19
Zhe Wu, Jiang Tan, Yujing Chi, Feng Zhang, Jun Xu, Yang Song, Xu Cong, Na Wu, Yulan Liu
Visceral adipose tissue (VAT) is related to non-alcoholic fatty liver disease (NAFLD). However, the role of mesenteric adipose tissue (MAT), part of the VAT, in NAFLD is unclear. In the present study, we monitored the liver and four depots of the VAT in high fat diet (HFD) feeding mice at multiple time points (4, 8, and 12 weeks). The MAT had become inflamed by the 8th week of HFD feeding, earlier than other depots of VAT. Furthermore, MAT removal after 8 weeks of HFD resulted in more severe steatosis and more foci of inflammation infiltration, as well as higher NAFLD activity scores...
June 14, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29901506/accuracy-of-automated-liver-contouring-fat-fraction-and-r2-measurement-on-gradient-multiecho-magnetic-resonance-images
#20
Daniel Stocker, Mustafa R Bashir, Stephan A R Kannengiesser, Cäcilia S Reiner
OBJECTIVE: This study aimed to evaluate the performance of an automated workflow of volumetric liver proton density fat fraction (PDFFvol) and R2* quantification with automated inline liver volume (LV) segmentation. METHODS: Dual-echo and multiecho Dixon magnetic resonance images were evaluated in 74 consecutive patients (group A, PDFF < 10%; B, PDFF ≥ 10%; C, R2* ≥ 100 s; D, post-hemihepatectomy). The values of PDFFvol and R2*vol measurements across the LV were generated on multiecho images in an automated fashion based on inline liver segmentation on dual-echo images...
June 12, 2018: Journal of Computer Assisted Tomography
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