keyword
MENU ▼
Read by QxMD icon Read
search

steatosis donor

keyword
https://www.readbyqxmd.com/read/28129776/administration-of-multipotent-mesenchymal-stromal-cells-restores-liver-regeneration-and-improves-liver-function-in-obese-mice-with-hepatic-steatosis-after-partial-hepatectomy
#1
Fernando Ezquer, Javiera Bahamonde, Ya-Lin Huang, Marcelo Ezquer
BACKGROUND: The liver has the remarkable capacity to regenerate in order to compensate for lost or damaged hepatic tissue. However, pre-existing pathological abnormalities, such as hepatic steatosis (HS), inhibits the endogenous regenerative process, becoming an obstacle for liver surgery and living donor transplantation. Recent evidence indicates that multipotent mesenchymal stromal cells (MSCs) administration can improve hepatic function and increase the potential for liver regeneration in patients with liver damage...
January 28, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28059835/donor-liver-small-droplet-macrovesicular-steatosis-is-associated-with-increased-risk-for-recipient-allograft-rejection
#2
Won-Tak Choi, Kuang-Yu Jen, Dongliang Wang, Mehdi Tavakol, John P Roberts, Ryan M Gill
Although donor livers with <30% large droplet macrovesicular steatosis (MaS) and/or small droplet MaS (irrespective of percentage) are considered safe to use, this consensus is based on variable definitions of MaS subtypes and/or without a reproducible scoring system. We analyzed 134 donor liver biopsies from allografts transplanted at University of California at San Francisco between 2000 and 2015 to determine whether large and/or small droplet MaS is a risk factor for poor outcomes. Large droplet MaS was defined as a fat droplet occupying greater than one half of an individual hepatocyte, with nuclear displacement, and scored as the percentage of total parenchymal area replaced by large fat droplets on ×40 magnification...
March 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28049553/validation-of-intimate-correlation-between-visceral-fat-and-hepatic-steatosis-quantitative-measurement-techniques-using-ct-for-area-of%C3%A2-fat-and-mr-for-hepatic-steatosis
#3
Moon Hyung Choi, Joon-Il Choi, Michael Yong Park, Sung Eun Rha, Soon Nam Oh, Seung Eun Jung, Jae Young Byun, Stephan Kannengiesser, Yohan Son
BACKGROUND & AIM: The relationship between obesity and hepatic steatosis is well known, and there are many methods to measure obesity and severity of hepatic steatosis. Because of advances in radiologic techniques, the areas of certain body components can be measured on computed tomography (CT) while the severity of hepatic steatosis can be measured by magnetic resonance spectroscopy (MRS) with high accuracy. The aim of this study is to investigate the relationship between degree of fatty infiltration of the liver measured by MRS and body composition measured from CT images...
December 18, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28043763/prediction-of-the-total-liver-weight-using-anthropological-clinical-parameters-does-complexity-result-in-better-accuracy
#4
Marc-Antoine Allard, Gaëlle Baillié, Carlos Castro-Benitez, Matthieu Faron, Frédérique Blandin, Daniel Cherqui, Denis Castaing, Antonio Sa Cunha, René Adam, Éric Vibert
BACKGROUND: The performance of linear models predicting Total Liver Weight (TLW) remains moderate. The use of more complex models such as Artificial Neural Network (ANN) and Generalized Additive Model (GAM) or including the variable "steatosis" may improve TLW prediction. This study aimed to assess the value of ANN and GAM and the influence of steatosis for predicting TLW. METHODS: Basic clinical and morphological variables of 1560 cadaveric donors for liver transplantation were randomly split into a training (2/3) and validation set (1/3)...
December 30, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28027788/non-alcoholic-fatty-liver-disease-and-subclinical-atherosclerosis-a-comparison-of-metabolically-versus-genetically-driven-excess-fat-hepatic-storage
#5
Alessia Di Costanzo, Laura D'Erasmo, Licia Polimeni, Francesco Baratta, Paola Coletta, Michele Di Martino, Lorenzo Loffredo, Ludovica Perri, Fabrizio Ceci, Anna Montali, Gabriella Girelli, Bruna De Masi, Antonio Angeloni, Carlo Catalano, Marianna Maranghi, Maria Del Ben, Francesco Angelico, Marcello Arca
BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) is frequently associated with atherosclerosis. However, it is unclear whether this association is related to excess fat liver storage per se or to metabolic abnormalities that typically accompany NAFLD. To investigate this, we compared individuals with hepatic steatosis driven by metabolic disturbances to those with hepatic steatosis associated with the rs738409 GG genotype in the patatin-like phospholipase domain-containing 3 gene (PNPLA3)...
December 21, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27988988/prediction-of-nonalcoholic-fatty-liver-in-prospective-liver-donors
#6
Narendra S Choudhary, Neeraj Saraf, Sanjiv Saigal, Ajay Duseja, Dheeraj Gautam, Lipika Lipi, Amit Rastogi, Sanjay Goja, Prashant Bhangui, Sumana K Ramchandra, Yalakanti Raghavendra Babu, Arvinder S Soin
BACKGROUND: metabolic risk factors should be important in addition to imaging for prediction of steatosis in prospective liver donors. MATERIALS AND METHODS: The study group included all prospective liver donors who had a liver biopsy during work-up. Risk factors of metabolic syndrome were analyzed and body mass index (BMI)≥25 Kg/M(2) was used in place of waist circumference.Three BMI cut-offs (25, 28 and 30 kg/m(2) ) and two CT measured liver attenuation index (LAI) cut-offs (<5 and ≤10) were used for steatosis assessmentof ≥5%, ≥10% and ≥20%...
December 17, 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/27981274/noninvasive-quantitative-estimation-of-hepatic-steatosis-by-ultrasound-a-comparison-of-the-hepato-renal-index-and-ultrasound-attenuation-index
#7
Heon-Ju Kwon, Kyoung Won Kim, Jin-Hee Jung, Sang Hyun Choi, Woo Kyoung Jeong, Bohyun Kim, Gi-Won Song, Sung-Gyu Lee
AIMS: To compare the accuracy of the ultrasound attenuation index (USAI) and hepato-renal index (HRI) for the diagnosis of hepatic steatosis (HS). MATERIAL AND METHODS: Two hundred and twenty-four potential living hepatic donors underwent US and subsequent US-guided liver biopsy. The USAI was calculated from US images with an 8 MHz transducer and HRI was measured on sagittal images with a clear visualization of both the liver and kidney. Using histological degrees of HS as the reference standard, we compared the performance of USAI and HRI for diagnosing HS ≥ 5% and ≥ 30% by receiver operating characteristic curve analysis...
December 5, 2016: Medical Ultrasonography
https://www.readbyqxmd.com/read/27915440/liver-steatosis-in-pre-transplant-liver-biopsies-can-be-quantified-rapidly-and-accurately-by-nuclear-magnetic-resonance-analysis
#8
Stefanie Bertram, Cathrin Myland, Sandra Swoboda, Anja Gallinat, Thomas Minor, Nils Lehmann, Michael Thie, Julia Kälsch, Leona Pott, Ali Canbay, Thomas Bajanowski, Henning Reis, Andreas Paul, Hideo A Baba
Donor livers marginally acceptable or acceptable according to extended criteria are more frequently transplanted due to the growing discrepancy between demand and availability of donor organs. One type of marginally acceptable graft is a steatotic donor liver, because it is more sensitive to ischemia-reperfusion injury. Thus, quantitative assessment of steatosis is crucial prior to liver transplantation. Extent of steatosis of 49 pre-reperfusion liver biopsies from patients who received orthotopic liver transplantation was assessed by three techniques: semi-quantitative histological evaluation, computerized histomorphometry, and NMR-based estimation of fat content...
February 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27906826/factors-associated-with-short-and-long-term-liver-graft-survival-in-the-united-kingdom-development-of-a-uk-donor-liver-index
#9
Dave Collett, Peter J Friend, Christopher Je Watson
BACKGROUND: A measure of donor liver quality, the donor liver index, was developed and validated for the UK population of transplant recipients. Unlike previously proposed measures, this index is only based on variables that are available at the point of retrieval, and so does not include cold ischaemic time. METHODS: Indices of liver quality were based on data from the UK Transplant Registry on all 7929 liver transplants between January 2000 and December 2014. RESULTS: The donor liver index (DLI) was based on factors shown to affect graft survival, which included donor age, sex, height, type (donor after brain death or circulatory death), bilirubin, smoking history, and whether the liver was split...
December 1, 2016: Transplantation
https://www.readbyqxmd.com/read/27890791/fecal-microbiota-manipulation-prevents-dysbiosis-and-alcohol-induced-liver-injury-in-mice
#10
Gladys Ferrere, Laura Wrzosek, Frédéric Cailleux, Williams Turpin, Virginie Puchois, Madeleine Spatz, Dragos Ciocan, Dominique Rainteau, Lydie Humbert, Cindy Hugot, Françoise Gaudin, Marie-Louise Noordine, Véronique Robert, Dominique Berrebi, Muriel Thomas, Sylvie Naveau, Gabriel Perlemuter, Anne-Marie Cassard
BACKGROUND AND AIMS: Alcoholic liver disease (ALD) is a leading cause of liver failure and mortality. In humans, severe alcoholic hepatitis is associated with key changes of intestinal microbiota (IM), which influences individual sensitivity to develop advanced ALD. We used the different susceptibility to ALD observed in two distinct animal facilities to test the efficiency of two complementary strategies (fecal microbiota transplantation and prebiotic treatment) to reverse dysbiosis and prevent ALD...
November 24, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27860296/impact-of-subnormothermic-machine-perfusion-preservation-in-severely-steatotic-rat-livers-a-detailed-assessment-in-an-isolated-setting
#11
Y Okamura, K Hata, H Tanaka, H Hirao, T Kubota, O Inamoto, S Kageyama, I Tamaki, N Yermek, J Yoshikawa, S Uemoto
The current drastic shortage of donor organs has led to acceptance of extended-criteria donors for transplantation, despite higher risk of primary nonfunction. Here, we report the impact of subnormothermic machine perfusion (SMP) preservation on the protection of >50% macrosteatotic livers. Dietary hepatic steatosis was induced in Wistar rats via 2-day fasting and subsequent 3-day re-feeding with a fat-free, carbohydrate-rich diet. This protocol induces 50-60% macrovesicular steatosis, which should be discarded when preserved via cold storage (CS)...
November 10, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27853271/foetal-programming-by-methyl-donor-deficiency-produces-steato-hepatitis-in-rats-exposed-to-high-fat-diet
#12
Anaïs Bison, Aude Marchal-Bressenot, Zhen Li, Ilef Elamouri, Eva Feigerlova, Lu Peng, Remi Houlgatte, Bernard Beck, Gregory Pourié, Jean-Marc Alberto, Remy Umoret, Guillaume Conroy, Jean-Pierre Bronowicki, Jean-Louis Guéant, Rosa-Maria Guéant-Rodriguez
Non-alcoholic steatohepatitis (NASH) is a manifestation of metabolic syndrome, which emerges as a major public health problem. Deficiency in methyl donors (folate and vitamin B12) during gestation and lactation is frequent in humans and produces foetal programming effects of metabolic syndrome, with small birth weight and liver steatosis at day 21 (d21), in rat pups. We investigated the effects of fetal programming on liver of rats born from deficient mothers (iMDD) and subsequently subjected to normal diet after d21 and high fat diet (HF) after d50...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27780188/liver-transplantation-with-older-donors-a-comparison-with-younger-donors-in-a-context-of-organ-shortage
#13
Louise Barbier, Manuela Cesaretti, Federica Dondero, François Cauchy, Linda Khoy-Ear, Takeshi Aoyagi, Emmanuel Weiss, Olivier Roux, Safi Dokmak, Claire Francoz, Catherine Paugam-Burtz, Ailton Sepulveda, Jacques Belghiti, François Durand, Olivier Soubrane
BACKGROUND: Older liver grafts have been considered in the past decade due to organ shortage. The aim was to compare outcomes after liver transplantation with either younger or older donors. METHODS: Patients transplanted in our center between 2004 and 2014 with younger donors (younger than 60 years; n = 253) were compared with older donors (older than 75 years; n = 157). Multiorgan transplantations, split grafts, or non-heart-beating donors were not included. RESULTS: Donors in the older group were mostly women deceased from stroke, and only 3 patients had experienced cardiac arrest...
November 2016: Transplantation
https://www.readbyqxmd.com/read/27545327/a-donor-body-mass-index-greater-than-30-is-not-a-contraindication-for-live-liver-donation
#14
M Knaak, N Goldaracena, A Doyle, M S Cattral, P D Greig, L Lilly, I D McGilvray, G A Levy, A Ghanekar, E L Renner, D R Grant, M Selzner, N Selzner
The increased prevalence of obesity worldwide threatens the pool of living liver donors. While the negative effects of graft steatosis on liver donation and transplantation is well known, the impact of obesity in the absence of hepatic steatosis on outcome of living donor liver transplantation (LDLT) is unknown. Therefore, we compared the outcome of LDLT using donors with a BMI<30kg/m(2) vs donors with a BMI ≥30kg/m(2) . Between April 2000-May 2014, 105 patients received a right lobe liver graft from donors with BMI ≥30kg/m(2) , while 364 recipients were transplanted with grafts from donors with BMI<30kg/m(2) ...
August 22, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27511316/donor-liver-steatosis-a-risk-factor-for-early-new-onset-diabetes-after-liver-transplantation
#15
Mengjuan Xue, Chaoyang Lv, Xianying Chen, Jing Liang, Chenhe Zhao, Yao Zhang, Xiaowu Huang, Qiman Sun, Ting Wang, Jian Gao, Jian Zhou, Mingxiang Yu, Jia Fan, Xin Gao
AIM: To investigate whether donor liver steatosis increases the incidence of new-onset diabetes after transplantation (NODAT) in liver transplant recipients. METHODS: We retrospectively analyzed liver transplant recipients at our hospital from April 2001 to December 2014. The final analysis involved 763 patients. The cumulative incidence of NODAT at 1, 3, 5, and 10 years after liver transplantation was investigated. Further, according to the findings of donor liver biopsy before transplantation, patients were divided into steatotic and non-steatotic donor liver groups, and NODAT incidence was compared between these groups...
August 10, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27503114/simultaneous-ct-angiography-and-whole-body-ct-is-an-effective-imaging-approach-before-multiorgan-retrieval
#16
E Berthier, C Ridereau-Zins, L Dubé, P Tchouante, C Nedelcu, S Lasocki, C Aubé
PURPOSE: To assess the role of whole-body computed tomography (CT) for determining morphological suitability before multiorgan retrieval (MOR) in brain dead patients. MATERIALS AND METHODS: Fifty-one clinically brain dead patients (21 women, 30 men; mean age 61 year±15) were included in this prospective, single center study. All patients had CT angiography of the brain and whole-body CT examination. CT images were evaluated for the presence of morphological abnormalities of lungs, liver and other abdominal organs and presence of vascular anatomical variants...
August 5, 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27495764/how-to-perform-selective-liver-biopsy-in-living-liver-donors-using-plain-computed-tomography
#17
Sun-Kyeong Moon, Yo-Han Park, Deok-Bog Moon, Shin Hwang, Chul-Soo Ahn, Ki-Hun Kim, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Gil-Chun Park, Sung-Gyu Lee
BACKGROUND: Preoperative liver biopsy in donor is the gold standard to verify the quality of liver. However, it can cause some complications and this study was designed to know whether selective liver biopsy is possible or not, and to find subgroup who does not require preoperative biopsy. METHODS: We review preoperative images and postoperative outcome in 118 donors from September 2013 to January 2014. Visual grading of steatosis on plain computed tomography(CT) was performed and compared steatosis on preoperative liver biopsy undergone within 7 days from the CT scan...
August 3, 2016: Transplantation
https://www.readbyqxmd.com/read/27479639/accuracy-of-mr-imaging-and-mr-spectroscopy-for-detection-and-quantification-of-hepatic-steatosis-in-living-liver-donors-a-meta-analysis
#18
Danping Zheng, Zhiyong Guo, Paul M Schroder, Zhouying Zheng, Yao Lu, Jincui Gu, Xiaoshun He
Purpose To determine the accuracy of magnetic resonance (MR) imaging for detection and quantification of hepatic steatosis (HS) in living liver donor candidates. Materials and Methods A systematic search of the literature was performed to find studies on the diagnostic and quantitative accuracy of MR imaging for assessment of HS in liver donors. The Quality Assessment of Diagnostic Accuracy Studies 2 tool was used, and patient selection, index text, reference standard, and study flow and timing were assessed to evaluate the quality of each included study...
January 2017: Radiology
https://www.readbyqxmd.com/read/27448628/fatty-liver-oxidative-events-monitored-by-autofluorescence-optical-diagnosis-a-comparison-between-subnormothermic-machine-perfusion-and-conventional-cold-storage-preservation
#19
Anna Cleta Croce, Andrea Ferrigno, Vittorio Bertone, Valeria Maria Piccolini, Clarissa Berardo, Laura Giuseppina Di Pasqua, Vittoria Rizzo, Giovanni Bottiroli, Mariapia Vairetti
AIM: Livers with moderate steatosis are currently recruited as marginal organs to face donor shortage in transplantation, despite lipid excess and oxidative stress increase preservation injury risk. A sensitive, real time detection of liver metabolism engagement could help donor selection and preservation procedures, ameliorating the graft outcome. Hence, we investigated endogenous biomolecules with autofluorescence (AF) properties as biomarkers supporting the detection of liver oxidative events and the assessment of metabolic responses to external stimuli...
July 23, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27428872/plasma-phospholipids-and-fatty-acid-composition-differ-between-liver-biopsy-proven-nonalcoholic-fatty-liver-disease-and-healthy-subjects
#20
D W L Ma, B M Arendt, L M Hillyer, S K Fung, I McGilvray, M Guindi, J P Allard
BACKGROUND: There is growing evidence that nonalcoholic fatty liver disease (NAFLD) is associated with perturbations in liver lipid metabolism. Liver phospholipid and fatty acid composition have been shown to be altered in NAFLD. However, detailed profiles of circulating lipids in the pathogenesis of NAFLD are lacking. OBJECTIVE: Therefore, the objective of the present study was to examine circulating lipids and potential mechanisms related to hepatic gene expression between liver biopsy-proven simple steatosis (SS), nonalcoholic steatohepatitis (NASH) and healthy subjects...
2016: Nutrition & Diabetes
keyword
keyword
50859
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"