Sergio Quesada-Vázquez, Anna Castells-Nobau, Jèssica Latorre, Núria Oliveras-Cañellas, Irene Puig-Parnau, Noemi Tejera, Yaiza Tobajas, Julio Baudin, Falk Hildebrand, Naiara Beraza, Rémy Burcelin, Laura Martinez-Gili, Julien Chilloux, Marc-Emmanuel Dumas, Massimo Federici, Lesley Hoyles, Antoni Caimari, Josep M Del Bas, Xavier Escoté, José-Manuel Fernández-Real, Jordi Mayneris-Perxachs
The gut microbiota contributes to the pathophysiology of non-alcoholic fatty liver disease (NAFLD). Histidine is a key energy source for the microbiota, scavenging it from the host. Its role in NAFLD is poorly known. Plasma metabolomics, liver transcriptomics, and fecal metagenomics were performed in three human cohorts coupled with hepatocyte, rodent, and Drosophila models. Machine learning analyses identified plasma histidine as being strongly inversely associated with steatosis and linked to a hepatic transcriptomic signature involved in insulin signaling, inflammation, and trace amine-associated receptor 1...
December 19, 2023: Cell reports medicine