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steatosis donor

Stefanie Bertram, Cathrin Myland, Sandra Swoboda, Anja Gallinat, Thomas Minor, Nils Lehmann, Michael Thie, Julia Kälsch, Leona Pott, Ali Canbay, Thomas Bajanowski, Henning Reis, Andreas Paul, Hideo A Baba
Donor livers marginally acceptable or acceptable according to extended criteria are more frequently transplanted due to the growing discrepancy between demand and availability of donor organs. One type of marginally acceptable graft is a steatotic donor liver, because it is more sensitive to ischemia-reperfusion injury. Thus, quantitative assessment of steatosis is crucial prior to liver transplantation. Extent of steatosis of 49 pre-reperfusion liver biopsies from patients who received orthotopic liver transplantation was assessed by three techniques: semi-quantitative histological evaluation, computerized histomorphometry, and NMR-based estimation of fat content...
December 3, 2016: Virchows Archiv: An International Journal of Pathology
Dave Collett, Peter J Friend, Christopher Je Watson
BACKGROUND: A measure of donor liver quality, the donor liver index, was developed and validated for the UK population of transplant recipients. Unlike previously proposed measures, this index is only based on variables that are available at the point of retrieval, and so does not include cold ischaemic time. METHODS: Indices of liver quality were based on data from the UK Transplant Registry on all 7929 liver transplants between January 2000 and December 2014. RESULTS: The donor liver index (DLI) was based on factors shown to affect graft survival, which included donor age, sex, height, type (donor after brain death or circulatory death), bilirubin, smoking history, and whether the liver was split...
December 1, 2016: Transplantation
Gladys Ferrere, Laura Wrzosek, Frédéric Cailleux, Williams Turpin, Virginie Puchois, Madeleine Spatz, Dragos Ciocan, Dominique Rainteau, Lydie Humbert, Cindy Hugot, Françoise Gaudin, Marie-Louise Noordine, Véronique Robert, Dominique Berrebi, Muriel Thomas, Sylvie Naveau, Gabriel Perlemuter, Anne-Marie Cassard
BACKGROUND AND AIMS: Alcoholic liver disease (ALD) is a leading cause of liver failure and mortality. In humans, severe alcoholic hepatitis is associated with key changes of intestinal microbiota (IM), which influences individual sensitivity to develop advanced ALD. We used the different susceptibility to ALD observed in two distinct animal facilities to test the efficiency of two complementary strategies (fecal microbiota transplantation and prebiotic treatment) to reverse dysbiosis and prevent ALD...
November 24, 2016: Journal of Hepatology
Y Okamura, K Hata, H Tanaka, H Hirao, T Kubota, O Inamoto, S Kageyama, I Tamaki, N Yermek, J Yoshikawa, S Uemoto
Current drastic shortage of donor organs has led to acceptance of extended-criteria donors for transplantation, despite higher risk of primary non-function. Here, we report the impact of subnormothermic machine perfusion (SMP) preservation on the protection of >50% macro-steatotic livers. Dietary hepatic steatosis was induced in Wistar rats via 2-day fasting and subsequent 3-day re-feeding with a fat-free, carbohydrate-rich diet. This protocol induces 50-60% macrovesicular steatosis, which should be discarded when preserved via cold storage (CS)...
November 10, 2016: American Journal of Transplantation
Anaïs Bison, Aude Marchal-Bressenot, Zhen Li, Ilef Elamouri, Eva Feigerlova, Lu Peng, Remi Houlgatte, Bernard Beck, Gregory Pourié, Jean-Marc Alberto, Remy Umoret, Guillaume Conroy, Jean-Pierre Bronowicki, Jean-Louis Guéant, Rosa-Maria Guéant-Rodriguez
Non-alcoholic steatohepatitis (NASH) is a manifestation of metabolic syndrome, which emerges as a major public health problem. Deficiency in methyl donors (folate and vitamin B12) during gestation and lactation is frequent in humans and produces foetal programming effects of metabolic syndrome, with small birth weight and liver steatosis at day 21 (d21), in rat pups. We investigated the effects of fetal programming on liver of rats born from deficient mothers (iMDD) and subsequently subjected to normal diet after d21 and high fat diet (HF) after d50...
November 17, 2016: Scientific Reports
Louise Barbier, Manuela Cesaretti, Federica Dondero, François Cauchy, Linda Khoy-Ear, Takeshi Aoyagi, Emmanuel Weiss, Olivier Roux, Safi Dokmak, Claire Francoz, Catherine Paugam-Burtz, Ailton Sepulveda, Jacques Belghiti, François Durand, Olivier Soubrane
BACKGROUND: Older liver grafts have been considered in the past decade due to organ shortage. The aim was to compare outcomes after liver transplantation with either younger or older donors. METHODS: Patients transplanted in our center between 2004 and 2014 with younger donors (younger than 60 years; n = 253) were compared with older donors (older than 75 years; n = 157). Multiorgan transplantations, split grafts, or non-heart-beating donors were not included. RESULTS: Donors in the older group were mostly women deceased from stroke, and only 3 patients had experienced cardiac arrest...
November 2016: Transplantation
M Knaak, N Goldaracena, A Doyle, M S Cattral, P D Greig, L Lilly, I D McGilvray, G A Levy, A Ghanekar, E L Renner, D R Grant, M Selzner, N Selzner
The increased prevalence of obesity worldwide threatens the pool of living liver donors. While the negative effects of graft steatosis on liver donation and transplantation is well known, the impact of obesity in the absence of hepatic steatosis on outcome of living donor liver transplantation (LDLT) is unknown. Therefore, we compared the outcome of LDLT using donors with a BMI<30kg/m(2) vs donors with a BMI ≥30kg/m(2) . Between April 2000-May 2014, 105 patients received a right lobe liver graft from donors with BMI ≥30kg/m(2) , while 364 recipients were transplanted with grafts from donors with BMI<30kg/m(2) ...
August 22, 2016: American Journal of Transplantation
Mengjuan Xue, Chaoyang Lv, Xianying Chen, Jing Liang, Chenhe Zhao, Yao Zhang, Xiaowu Huang, Qiman Sun, Ting Wang, Jian Gao, Jian Zhou, Mingxiang Yu, Jia Fan, Xin Gao
AIM: To investigate whether donor liver steatosis increases the incidence of new-onset diabetes after transplantation (NODAT) in liver transplant recipients. METHODS: We retrospectively analyzed liver transplant recipients at our hospital from April 2001 to December 2014. The final analysis involved 763 patients. The cumulative incidence of NODAT at 1, 3, 5, and 10 years after liver transplantation was investigated. Further, according to the findings of donor liver biopsy before transplantation, patients were divided into steatotic and non-steatotic donor liver groups, and NODAT incidence was compared between these groups...
August 10, 2016: Journal of Diabetes Investigation
E Berthier, C Ridereau-Zins, L Dubé, P Tchouante, C Nedelcu, S Lasocki, C Aubé
PURPOSE: To assess the role of whole-body computed tomography (CT) for determining morphological suitability before multiorgan retrieval (MOR) in brain dead patients. MATERIALS AND METHODS: Fifty-one clinically brain dead patients (21 women, 30 men; mean age 61 year±15) were included in this prospective, single center study. All patients had CT angiography of the brain and whole-body CT examination. CT images were evaluated for the presence of morphological abnormalities of lungs, liver and other abdominal organs and presence of vascular anatomical variants...
August 5, 2016: Diagnostic and Interventional Imaging
Sun-Kyeong Moon, Yo-Han Park, Deok-Bog Moon, Shin Hwang, Chul-Soo Ahn, Ki-Hun Kim, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Gil-Chun Park, Sung-Gyu Lee
BACKGROUND: Preoperative liver biopsy in donor is the gold standard to verify the quality of liver. However, it can cause some complications and this study was designed to know whether selective liver biopsy is possible or not, and to find subgroup who does not require preoperative biopsy. METHODS: We review preoperative images and postoperative outcome in 118 donors from September 2013 to January 2014. Visual grading of steatosis on plain computed tomography(CT) was performed and compared steatosis on preoperative liver biopsy undergone within 7 days from the CT scan...
August 3, 2016: Transplantation
Danping Zheng, Zhiyong Guo, Paul M Schroder, Zhouying Zheng, Yao Lu, Jincui Gu, Xiaoshun He
Purpose To determine the accuracy of magnetic resonance (MR) imaging for detection and quantification of hepatic steatosis (HS) in living liver donor candidates. Materials and Methods A systematic search of the literature was performed to find studies on the diagnostic and quantitative accuracy of MR imaging for assessment of HS in liver donors. The Quality Assessment of Diagnostic Accuracy Studies 2 tool was used, and patient selection, index text, reference standard, and study flow and timing were assessed to evaluate the quality of each included study...
August 1, 2016: Radiology
Anna Cleta Croce, Andrea Ferrigno, Vittorio Bertone, Valeria Maria Piccolini, Clarissa Berardo, Laura Giuseppina Di Pasqua, Vittoria Rizzo, Giovanni Bottiroli, Mariapia Vairetti
AIM: Livers with moderate steatosis are currently recruited as marginal organs to face donor shortage in transplantation, despite lipid excess and oxidative stress increase preservation injury risk. A sensitive, real time detection of liver metabolism engagement could help donor selection and preservation procedures, ameliorating the graft outcome. Hence, we investigated endogenous biomolecules with autofluorescence (AF) properties as biomarkers supporting the detection of liver oxidative events and the assessment of metabolic responses to external stimuli...
July 23, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
D W L Ma, B M Arendt, L M Hillyer, S K Fung, I McGilvray, M Guindi, J P Allard
BACKGROUND: There is growing evidence that nonalcoholic fatty liver disease (NAFLD) is associated with perturbations in liver lipid metabolism. Liver phospholipid and fatty acid composition have been shown to be altered in NAFLD. However, detailed profiles of circulating lipids in the pathogenesis of NAFLD are lacking. OBJECTIVE: Therefore, the objective of the present study was to examine circulating lipids and potential mechanisms related to hepatic gene expression between liver biopsy-proven simple steatosis (SS), nonalcoholic steatohepatitis (NASH) and healthy subjects...
2016: Nutrition & Diabetes
Sangbin Han, Sang-Man Jin, Justin Sangwook Ko, Young Ri Kim, Mi Sook Gwak, Hee Jeong Son, Jae-Won Joh, Gaab Soo Kim
BACKGROUND: Intermittent hepatic inflow occlusion (IHIO) is associated with acute hyperglycemia during living donor hepatectomy when the ischemia is prolonged. Bilirubin is a potent antioxidant to play an important role for maintaining insulin sensitivity and preventing hyperglycemia. Thus, we aimed to test whether serum bilirubin level is associated with prolonged IHIO-induced intraoperative hyperglycemia. METHODS: Seventy-five living liver donors who underwent a prolonged IHIO with a >30 minute cumulative ischemia were included...
2016: PloS One
Zhenyu Xiao, Babak Banan, Min Xu, Jianluo Jia, Pamela T Manning, Ronald R Hiebsch, Muthukumar Gunasekaran, Gundumi A Upadhya, William A Frazier, Thalachallour Mohanakumar, Yiing Lin, William C Chapman
BACKGROUND: Despite the efficacy of orthotopic liver transplantation in the treatment of end-stage liver diseases, its therapeutic utility is severely limited by the availability of donor organs. The ability to rehabilitate marginal organs, such as steatotic allografts, has the potential to address some of the supply limitations of available organs for transplantation. Steatotic livers are more susceptible to ischemia-reperfusion injury (IRI), which is exacerbated by the thrombospondin-1/CD47 pathway through inhibition of nitric oxide signaling...
July 2016: Transplantation
H-J Chiang, W-P Chang, H-W Chiang, M Z Lazo, T-Y Chen, H-Y Ou, L L-C Tsang, T-L Huang, C-L Chen, Y-F Cheng
OBJECTIVE: The purpose of this study is to evaluate the accuracy rate of the one breath-hold single voxel hydrogen-1 magnetic resonance spectroscopy (MRS) in comparison with intraoperative biopsy for liver fat quantification in living-donor liver transplantation. MATERIALS AND METHODS: A total of 80 living liver donors participated in this study. Each patient underwent both MRS and intraoperative biopsy for evaluation of liver fatty content. MRS was performed using 1...
May 2016: Transplantation Proceedings
N Akamatsu, N Kokudo
OBJECTIVES: Donor selection and operative procedures for adult-to-adult living donor liver transplantation at the University of Tokyo are presented. METHODS: Donor selection criteria are as follows: age between 20 and 65 years, within 3 degrees of consanguinity, without coercion, free from any major comorbidities, body mass index (BMI) < 30, and ABO blood type identical or compatible. Liver biopsy is indicated for BMI > 25 kg/m(2) or any liver function abnormality, and those with macroscopic steatosis >10% are rejected...
May 2016: Transplantation Proceedings
Adam Doyle, Oyedele Adeyi, Korosh Khalili, Sandra Fischer, Martin Dib, Nicolas Goldaracena, Jayne Dillon, David Grant, Mark Cattral, Ian McGilvray, Paul Greig, Anand Ghanekar, Leslie Lilly, Eberhard Renner, Gary Levy, Nazia Selzner
No abstract text is available yet for this article.
September 2016: Liver Transplantation
Maham Jehangir, Rashed Nazir, Aisha Jang, Atif Rana, Salman Rafique, Faisal Saud Dar
BACKGROUND: Hepatic steatosis threatens post-transplant graft survival; therefore, pre-operative quantification of steatosis is crucial. Gold standard for evaluation is donor liver biopsy but it is invasive. An alternative non-invasive method is a calculation of CT liver attenuation index. BMI can be an independent factor predicting grade of steatosis but it is necessary to re-define appropriate BMI cut-off points that are specific for Asians. OBJECTIVE: To retrospectively analyze CT LAI and BMI for quantitative assessment of macrovesicular steatosis in living related liver donors, using histological analysis as gold standard...
September 2016: Clinical Transplantation
Gi-Won Song, Sung-Gyu Lee, Deok-Bog Moon, Chul-Soo Ahn, Shin Hwang, Ki-Hum Kim, Tae-Yong Ha, Dong-Hwan Jung
OBJECTIVE: To detail the surgical technique and outcomes of dual-graft (DG) adult living donor liver transplantation (ALDLT). BACKGROUND: DG ALDLT has a great potential for expanding the living donor pool without increasing donor risk. However, little is known about DG ALDLT because it has been performed by a limited number of institutions due to its technical complexity. METHODS: The clinical data of patients who underwent DG ALDLT at a single institute between March 2000 and December 2014 were retrospectively reviewed...
May 17, 2016: Annals of Surgery
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