Xihao Pan, Rui Li, Wenyue Li, Wei Sun, Yiyang Yan, Xiaochen Xiang, Jinghua Fang, Youguo Liao, Chang Xie, Xiaozhao Wang, Youzhi Cai, Xudong Yao, Hongwei Ouyang
Despite orientationally variant tears of the meniscus, suture repair is the current clinical gold treatment. However, inaccessible tears in company with re-tears susceptibility remain unresolved. To extend meniscal repair tools from the perspective of adhesion and regeneration, we design a dual functional biologic-released bioadhesive (S-PIL10) comprised of methacrylated silk fibroin crosslinked with phenylboronic acid-ionic liquid loading with growth factor TGF-β1, which integrates chemo-mechanical restoration with inner meniscal regeneration...
March 26, 2024: Nature Communications