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Survivors of childhood cancer

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https://www.readbyqxmd.com/read/29158370/ovarian-and-uterine-functions-in-female-survivors-of-childhood-cancers
#1
REVIEW
Ozgur Oktem, Samuel S Kim, Ugur Selek, Glenn Schatmann, Bulent Urman
Adult survivors of childhood cancers are more prone to developing poor reproductive and obstetrical outcomes than their siblings and the general population as a result of previous exposure to chemotherapy and radiation during childhood. Chemotherapy drugs exert cytotoxic effects systemically and therefore can damage the ovaries, leading to infertility, premature ovarian failure, and, to a lesser extent, spontaneous abortions. They have very limited or no deleterious effects on the uterus that can be recognized clinically...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29147881/childhood-cancer-and-brain-tumor-late-effects-relationships-with-family-burden-and-survivor-psychological-outcomes
#2
Melissa K Cousino, Rebecca Hazen, Katherine Leigh Josie, Kelly Laschinger, Peter de Blank, H Gerry Taylor
This study examines illness-specific family burden as a mediator of the association between late effects of childhood cancer and survivors' emotional and behavioral outcomes. Childhood cancer survivors (n = 65; ages 10-17) two or more years off-treatment completed measures assessing internalizing and PTSD symptoms. Parents reported on illness-specific family burden, late effects severity, and survivor internalizing/externalizing problems. Providers documented the number of late effects. Illness-specific family burden was correlated with provider-reported late effects (r = ...
November 16, 2017: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29144813/diagnosing-and-monitoring-endocrine-dysfunction-diabetes-and-obesity-in-a-cohort-of-adult-survivors-of-childhood-cancer
#3
Victoria Rollins Hudspeth, Stuart Harrison Gold, David Robert Clemmons
OBJECTIVE: 5-year survival for childhood cancer has increased to 80%, resulting in a growing population of adult survivors of childhood cancer (ASOCC). Long-term endocrine dysfunction is as high as 63% when screened in research protocols. The purpose of this study was to evaluate the prevalence of endocrine testing, endocrine dysfunction, diabetes, obesity, and endocrinologist visits outside of a research screening protocol. METHODS: Retrospective chart review was performed for 176 ASOCC who were diagnosed with cancer before age 18, followed at least 10 years, were now at least 18, and had survived to the time of chart review...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29135108/addressing-the-post-irradiation-hypothalamic-pituitary-endocrine-abnormalities-of-brain-tumors-in-pediatric-patients
#4
Louloudenia Velentza, Maria Tolia, Charikleia Christakou, Michail Nikolaou, Ioannis Zerdes, Nikolaos Tsoukalas, Jiannis Hajiioannou, Konstantinos Tsanadis, Georgios Rigas, Michail Mitsis, Kyriaki Theodorou, Kyriaki Pistevou-Gombaki, Periklis Tsekeris, George Kyrgias
PURPOSE: Hypothalamic-pituitary axis is susceptible to radiotherapy, causing endocrine disorders to childhood cancer survivors. We conducted a systematic review in order to assess the radiation-induced toxicity that leads to hormone secretion abnormalities and their severity in children with brain tumors. METHODS: The data were collected by relevant studies on PubMed and EMBASE. Articles up to December 2016 were included. We selected studies which focused on children patients (<18 yr old) with brain tumors treated with radiotherapy and the consequences for their endocrine system...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29124416/prevalence-and-correlates-of-health-information-seeking-among-hispanic-and-non-hispanic-childhood-cancer-survivors
#5
Kimberly A Miller, Cynthia N Ramirez, Katherine Y Wojcik, Anamara Ritt-Olson, Lourdes Baezconde-Garbanati, Stefanie M Thomas, David R Freyer, Ann S Hamilton, Joel E Milam
PURPOSE: Childhood cancer survivors (CCS) report high unmet information needs. This study examined the prevalence of cancer-related information-seeking among CCS and investigated associations between information-seeking behavior and positive health outcomes such as follow-up care. METHODS: Participants (n = 193) were young adult CCS diagnosed with cancer in Los Angeles County, 54% of Hispanic ethnicity, with a mean age of 19.87, in remission, and at least 2 years from completion of treatment...
November 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29106752/subclinical-anthracycline-induced-cardiotoxicity-in-long-term-follow-up-of-asymptomatic-childhood-cancer-survivors-assessment-by-speckle-tracking-echocardiography
#6
Süha Çetin, Kadir Babaoğlu, Eviç Z Başar, Murat Deveci, Funda Çorapçıoğlu
OBJECTIVE: Survivors of childhood cancer treated with anthracyclines carry the risk for developing late-onset cardiotoxicity. The purpose of this study was to evaluate left ventricular (LV) function in this patient group and compare it with healthy controls by means of conventional and speckle tracking echocardiography (STE) after exposure to chemotherapy. MATERIAL AND METHODS: Conventional and STE were performed in 45 childhood cancer survivors (mean age 11 ± 4...
November 6, 2017: Echocardiography
https://www.readbyqxmd.com/read/29105081/long-term-sequelae-in-survivors-of-childhood-leukemia-with-down-syndrome-a-childhood-cancer-survivor-study-report
#7
Robert E Goldsby, Kayla L Stratton, Shannon Raber, Arthur Ablin, Louise C Strong, Kevin Oeffinger, Charles A Sklar, Gregory T Armstrong, Leslie L Robison, Smita Bhatia, Wendy M Leisenring
BACKGROUND: Children with Down syndrome (DS) are at increased risk of developing acute leukemia and are more prone to acute toxicities. We studied the incidence and severity of chronic health conditions among survivors of childhood leukemia with DS compared with those without DS. METHODS: Chronic health conditions reported by questionnaire were compared between 154 pediatric leukemia survivors with DS and 581 without DS, matched by leukemia, age at diagnosis, race/ethnicity, sex, radiation location and chemotherapy exposure using Cox models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs)...
November 3, 2017: Cancer
https://www.readbyqxmd.com/read/29101712/posttraumatic-stress-related-psychological-functioning-in-adult-survivors-of-childhood-cancer
#8
Jennifer Allen, Victoria W Willard, James L Klosky, Chenghong Li, D Kumar Srivastava, Leslie L Robison, Melissa M Hudson, Sean Phipps
PURPOSE: The majority of research examining posttraumatic stress symptoms/disorder (PTSS/PTSD) among adult survivors of childhood cancer has been oriented to cancer, assuming that cancer has been the most traumatic experience in their lives. Whether that assumption is valid, and how it might impact assessment of PTSS, is unknown. METHODS: Survivors in the St. Jude Lifetime Cohort study completed an assessment of PTSS without cancer orientation, global psychological functioning, perceived stress, and cancer-related anxiety...
November 3, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29099645/re-the-effect-of-atorvastatin-on-vascular-function-and-structure-in-young-adult-survivors-of-childhood-cancer-a-randomized-placebo-controlled-pilot-clinical-trial-by-marlatt-et-al-j-adolesc-young-adult-oncol-2017-epub-ahead-of-print-doi-10-1089-jayao-2017-0075
#9
https://www.readbyqxmd.com/read/29095680/prediction-of-ischemic-heart-disease-and-stroke-in-survivors-of-childhood-cancer
#10
Eric J Chow, Yan Chen, Melissa M Hudson, Elizabeth A M Feijen, Leontien C Kremer, William L Border, Daniel M Green, Lillian R Meacham, Daniel A Mulrooney, Kirsten K Ness, Kevin C Oeffinger, Cécile M Ronckers, Charles A Sklar, Marilyn Stovall, Helena J van der Pal, Irma W E M van Dijk, Flora E van Leeuwen, Rita E Weathers, Leslie L Robison, Gregory T Armstrong, Yutaka Yasui
Purpose We aimed to predict individual risk of ischemic heart disease and stroke in 5-year survivors of childhood cancer. Patients and Methods Participants in the Childhood Cancer Survivor Study (CCSS; n = 13,060) were observed through age 50 years for the development of ischemic heart disease and stroke. Siblings (n = 4,023) established the baseline population risk. Piecewise exponential models with backward selection estimated the relationships between potential predictors and each outcome. The St Jude Lifetime Cohort Study (n = 1,842) and the Emma Children's Hospital cohort (n = 1,362) were used to validate the CCSS models...
November 2, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29094652/comparing-the-knowledge-of-parents-and-survivors-who-attend-a-survivorship-clinic
#11
Joanne Quillen, Yimei Li, Michele Demski, Claire Carlson, Holli Bradley, Lisa Schwartz, Jill P Ginsberg, Wendy Hobbie
BACKGROUND: This study underscores the importance of the survivor/parent dynamic in understanding the knowledge level of childhood cancer survivors and their parents with regard to cancer diagnosis, treatments, and potential late effects, and to assess the impact of parental knowledge on survivor's knowledge. PROCEDURE: A convenience sample (N = 219 dyads) consisting of childhood cancer survivors with a parent match was used. Survivors 2 years out from completion of therapy, aged 16 to 25 years, and fluent in English or Spanish completed 2 questionnaires to assess adolescent and young adult and parental knowledge regarding diagnosis, treatment, and long-term risks...
November 1, 2017: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/29090422/health-related-quality-of-life-and-psychological-distress-in-young-adult-survivors-of-childhood-cancer-and-their-association-with-treatment-education-and-demographic-factors
#12
Janne F Halvorsen, Anne Mari Sund, Lonnie Zeltzer, Marian Ådnanes, Heidi Jensberg, Terje A Eikemo, Bendik Lund, Odin Hjemdal, Trude Reinfjell
PURPOSE: This study investigated health-related quality of life (HRQOL) and psychological distress among young adult (YA) survivors of childhood cancer and the association of these measures with treatment, education, and demographic factors ≥ 5 years post diagnosis. METHODS: Participants included cancer survivors (n = 91) recruited through the Cancer Registry of Norway (CRN) and healthy controls (n = 223) recruited from a student population. All participants completed self-report questionnaires, and the Pediatric Quality of Life Inventory (PedsQL™) 4...
October 31, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29077266/increased-prescription-rates-of-anxiolytics-and-hypnotics-to-survivors-of-cancer-in-childhood-adolescence-and-young-adulthood-a-population-based-study
#13
Inga Maria Johannsdottir, Jon H Loge, Cecilie E Kiserud, Øystein Karlstad, Svetlana Skurtveit
BACKGROUND: Survivors of cancer diagnosed in childhood, adolescence, or young adulthood (CAYACS) risk psychological morbidities later in life. The study compares prescription rates of anxiolytics and hypnotics among survivors to rates in age- and gender-matched controls. PROCEDURES: The population-based cohort included 5,341 cancer survivors, diagnosed ≤25 years of age during 1965-2000. For each survivor, three age- and gender-matched controls were randomly selected from the general population...
October 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29065109/risk-stratification-of-childhood-cancer-survivors-necessary-for-evidence-based-clinical-long-term-follow-up
#14
Clare Frobisher, Adam Glaser, Gill A Levitt, David J Cutter, David L Winter, Emma R Lancashire, Kevin C Oeffinger, Joyeeta Guha, Julie Kelly, Raoul C Reulen, Michael M Hawkins
BACKGROUND: Reorganisation of clinical follow-up care in England was proposed by the National Cancer Survivorship Initiative (NCSI), based on cancer type and treatment, ranging from Level 1 (supported self-management) to Level 3 (consultant-led care). The objective of this study was to provide an investigation of the risks of serious adverse health-outcomes associated with NCSI Levels of clinical care using a large population-based cohort of childhood cancer survivors. METHODS: The British Childhood Cancer Survivor Study (BCCSS) was used to investigate risks of specific causes of death, subsequent primary neoplasms (SPNs) and non-fatal non-neoplastic outcomes by NCSI Level...
October 24, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29059437/obstetrical-care-in-survivors-of-childhood-cancer-utilization-of-unique-linked-databases-to-further-refine-consensus-guidelines
#15
Kara M Kelly, Jennifer M Levine
No abstract text is available yet for this article.
November 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29059431/genetic-determinants-of-breast-cancer-risk-in-childhood-cancer-survivors
#16
Magda Meier, Nick Orr
No abstract text is available yet for this article.
November 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29059430/genome-wide-association-study-to-identify-susceptibility-loci-that-modify-radiation-related-risk-for-breast-cancer-after-childhood-cancer
#17
MULTICENTER STUDY
Lindsay M Morton, Joshua N Sampson, Gregory T Armstrong, Ting-Huei Chen, Melissa M Hudson, Eric Karlins, Casey L Dagnall, Shengchao Alfred Li, Carmen L Wilson, Deo Kumar Srivastava, Wei Liu, Guolian Kang, Kevin C Oeffinger, Tara O Henderson, Chaya S Moskowitz, Todd M Gibson, Diana M Merino, Jeannette R Wong, Sue Hammond, Joseph P Neglia, Lucie M Turcotte, Jeremy Miller, Laura Bowen, William A Wheeler, Wendy M Leisenring, John A Whitton, Laurie Burdette, Charles Chung, Belynda D Hicks, Kristine Jones, Mitchell J Machiela, Aurelie Vogt, Zhaoming Wang, Meredith Yeager, Geoffrey Neale, Matthew Lear, Louise C Strong, Yutaka Yasui, Marilyn Stovall, Rita E Weathers, Susan A Smith, Rebecca Howell, Stella M Davies, Gretchen A Radloff, Kenan Onel, Amy Berrington de González, Peter D Inskip, Preetha Rajaraman, Joseph F Fraumeni, Smita Bhatia, Stephen J Chanock, Margaret A Tucker, Leslie L Robison
Background: Childhood cancer survivors treated with chest-directed radiotherapy have substantially elevated risk for developing breast cancer. Although genetic susceptibility to breast cancer in the general population is well studied, large-scale evaluation of breast cancer susceptibility after chest-directed radiotherapy for childhood cancer is lacking. Methods: We conducted a genome-wide association study of breast cancer in female survivors of childhood cancer, pooling two cohorts with detailed treatment data and systematic, long-term follow-up: the Childhood Cancer Survivor Study and St...
November 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29050706/endocrine-sequelae-in-childhood-cancer-survivors
#18
Paula Casano Sancho
Thanks to the advances in cancer treatment, the five-year survival rate after childhood cancer has increased up to 80%. Therefore 1/500 young adults will be a survivor. Endocrine sequelae are most common, affecting 40-60% of survivors. The most frequent sequelae include growth failure and gonadal and thyroid diseases. Sequelae occur more frequently in survivors from central nervous system tumors, leukemia, and lymphoma. Their development will depend on the type of cancer, its location, age at diagnosis, and treatment administered...
November 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/29049517/-job-lock-among-long-term-survivors-of-childhood-cancer-a-report-from-the-childhood-cancer-survivor-study
#19
Anne C Kirchhoff, Ryan Nipp, Echo L Warner, Karen Kuhlthau, Wendy M Leisenring, Karen Donelan, Julia Rabin, Giselle K Perez, Kevin C Oeffinger, Paul C Nathan, Leslie L Robison, Gregory T Armstrong, Elyse R Park
Importance: Childhood cancer survivors may be reluctant to make changes in their employment because of access to health insurance. Objective: To examine the prevalence of "job lock" (staying at a job to keep work-related health insurance) in a sample drawn from an established, multi-institutional cohort of full-time employed childhood cancer survivors compared with a random sample of siblings and to explore factors associated with job lock among cancer survivors...
October 19, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29046041/development-and-content-validation-of-the-transition-readiness-inventory-item-pool-for-adolescent-and-young-adult-survivors-of-childhood-cancer
#20
Lisa A Schwartz, Jessica L Hamilton, Lauren D Brumley, Lamia P Barakat, Janet A Deatrick, Dava E Szalda, Katherine B Bevans, Carole A Tucker, Lauren C Daniel, Eliana Butler, Anne E Kazak, Wendy L Hobbie, Jill P Ginsberg, Alexandra M Psihogios, Elizabeth Ver Hoeve, Lisa K Tuchman
Objective: The development of the Transition Readiness Inventory (TRI) item pool for adolescent and young adult childhood cancer survivors is described, aiming to both advance transition research and provide an example of the application of NIH Patient Reported Outcomes Information System methods. Methods: Using rigorous measurement development methods including mixed methods, patient and parent versions of the TRI item pool were created based on the Social-ecological Model of Adolescent and young adult Readiness for Transition (SMART)...
October 1, 2017: Journal of Pediatric Psychology
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