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Survivors of childhood cancer

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https://www.readbyqxmd.com/read/29317383/research-and-practice-based-nutrition-education-and-cooking-workshops-in-pediatric-oncology-protocol-for-implementation-and-development-of-curriculum
#1
Cynthia Chaput, Sabrina Beaulieu-Gagnon, Véronique Bélanger, Simon Drouin, Laurence Bertout, Lucie Lafrance, Cinthia Olivier, Marthe Robitaille, Caroline Laverdière, Daniel Sinnett, Marie Marquis, Valérie Marcil
BACKGROUND: Progresses in childhood cancer treatment, diagnosis, and management have resulted in childhood cancer survival rates of over 80%. However, this therapeutic success comes with a heavy price: two-thirds of childhood cancer survivors will be affected by further complications, including cardiovascular and metabolic diseases. Adequate nutrition during cancer treatment is essential to ensure the child's optimal development, improve tolerance to treatments, and can contribute to lower the risk of developing cardiometabolic diseases...
January 9, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29316709/screaming-body-and-silent-healthcare-providers-a-case-study-with-a-childhood-sexual-abuse-survivor
#2
REVIEW
Sigrun Sigurdardottir, Sigridur Halldorsdottir
Stressful early life experiences cause immune dysregulation across the lifespan. Despite the fact that studies have identified childhood sexual abuse (CSA) survivors as a particularly vulnerable group, only a few attempts have been made to study their lived-experience of the physical health consequences of CSA. The aim of this study was to explore a female CSA survivor's lived-experience of the physical health consequences of CSA and how she experienced the reactions of healthcare providers. Seven interviews were conducted with this 40-year-old woman, Anne, using a phenomenological research approach...
January 8, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29286558/family-history-taking-practices-and-genetic-confidence-in-primary-and-tertiary-care-providers-for-childhood-cancer-survivors
#3
Claire E Wakefield, Veronica F Quinn, Joanna E Fardell, Christina Signorelli, Katherine M Tucker, Andrea F Patenaude, David Malkin, Thomas Walwyn, Frank Alvaro, Richard J Cohn
BACKGROUND: There is growing impetus for increased genetic screening in childhood cancer survivors. Family history-taking is a critical first step in determining survivors' suitability. However, the family history-taking practices of providers of pediatric oncology survivorship care and the confidence of these providers to discuss cancer risks to relatives are unknown. PROCEDURE: Fifty-four providers completed semistructured interviews in total, which included eight tertiary providers representing nine hospitals across two countries (63% male, 63% oncologists, 37% nurses) and 46 primary care providers (PCPs) nominated by a survivor (59% male, 35% regional practice)...
December 29, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29273944/health-status-of-polish-children-and-adolescents-after-cancer-treatment
#4
Krawczuk-Rybak Maryna, Panasiuk Anna, Stachowicz-Stencel Teresa, Zubowska Małgorzata, Skalska-Sadowska Jolanta, Sęga-Pondel Dorota, Czajńska-Deptuła Aneta, Sławińska Dorota, Badowska Wanda, Kamieńska Elżbieta, Pobudejska-Pieniążek Aneta, Wieczorek Maria
In the last 40 years, considerable progress was made in the treatment of childhood cancer. Nearly 80% of children achieve long-term clinical remission or are permanently cured. This improvement is however not without sacrifice. This is the first Polish study analyzing the general health status and epidemiology of organ late effects in the cohort of Polish childhood and adolescent cancer survivors monitored by doctors and registered in the on-line national database for late effects (N = 1761). This tool collects information on previous therapy and current health status (medical history, physical examination, laboratory tests) of cancer survivors...
December 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29258538/predominance-of-girls-with-cancer-in-families-with-multiple-childhood-cancer-cases
#5
Karl-Johan Stjernfelt, Kristoffer von Stedingk, Thomas Wiebe, Lars Hjorth, Håkan Olsson, Ingrid Øra
BACKGROUND: Recent studies indicate that one of four childhood cancers can be attributed to hereditary genetic abnormalities. METHODS: The Lund Childhood Cancer Genetic study includes newly diagnosed childhood cancer patients as well as childhood cancer survivors visiting the Department of Pediatrics or the Late Effect Clinic at Skåne University Hospital, Lund, Sweden. Questionnaires regarding family history of cancer and blood samples were provided. Reported data were validated and extended by use of the Swedish Population- and Cancer Registries...
December 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29245176/high-risk-of-hypogonadism-in-young-male-cancer-survivors
#6
S Isaksson, K Bogefors, O Ståhl, J Eberhard, Y Lundberg Giwercman, I Leijonhufvud, K Link, I Øra, P Romerius, J Bobjer, A Giwercman
OBJECTIVE: Cancer and its treatment in childhood and young adulthood can cause hypogonadism, leading to increased risk of long term morbidity and mortality. The aim of this study was to evaluate the risk of presenting with biochemical signs of hypogonadism in testicular cancer survivors (TCS) and male childhood cancer survivors (CCS) in relation to the type of treatment given. DESIGN: Case-control study. PATIENTS: Ninety-two TCS, 125 CCS (mean age 40 and median age 34 years, respectively; mean follow-up time 9...
December 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29244117/quality-of-life-self-esteem-and-future-expectations-of-adolescent-and-young-adult-cancer-survivors
#7
Kareen N Tonsing, Rosaleen Ow
Significant advancements in treatment modalities over the past few decades have significantly improved the survival rates of many types of childhood cancer, directing attention to the psychosocial consequences of successful treatment and subsequent survival. This study assesses quality of life (QoL) among survivors of childhood cancer. Data were collected by means of a survey questionnaire. Participants were assured of confidentiality and of the voluntary nature of participation. Participants ranged in age from 12 to 24 years (mean age = 17...
December 13, 2017: Health & Social Work
https://www.readbyqxmd.com/read/29240025/hypovitamininosis-d-in-childhood-cancer-survivors-importance-of-vitamin-d-supplementation-and-measurement-over-different-points-of-time
#8
Ashraf Fouda, Shaimaa Kandil, Khadijah Boujettif, Najwa Fayea
This observational retrospective cross-sectional and case-controlled study measures levels of 25-hydroxy-vitamin D (25-OH-VD) in pediatric cancer survivors at different intervals and assesses the effect of 2 supplementation regimens over a period of 12 months. Sixty-eight patients were included in this quasi-experimental study, of which 32 were boys and 36 were girls. A control group of 30 healthy children were included. It was found that initial 25-OH-VD levels were insufficient (<30 ng/mL) in 61 patients (89...
December 12, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29231963/body-composition-in-long-term-survivors-of-acute-lymphoblastic-leukemia-diagnosed-in-childhood-and-adolescence-a-focus-on-sarcopenic-obesity
#9
Christopher J C Marriott, Lesley F Beaumont, Troy H Farncombe, Amy N Cranston, Uma H Athale, Valerie N Yakemchuk, Colin E Webber, Ronald D Barr
BACKGROUND: The late effects of treatment for acute lymphoblastic leukemia (ALL) include disordered body composition, especially obesity. Less attention has been focused on the loss of skeletal muscle mass (SMM) and the combined morbidity of sarcopenic obesity. METHODS: A cross-sectional study of body composition was undertaken via dual-energy x-ray absorptiometry in 75 long-term survivors of ALL (more than 10 years after the diagnosis). Measures were obtained of the fat mass (FM), fat-free mass (equivalent to the lean body mass [LBM]), and whole-body bone mineral content...
December 12, 2017: Cancer
https://www.readbyqxmd.com/read/29230080/cancer-victim-identity-for-individuals-with-histories-of-cancer-and-childhood-sexual-abuse
#10
Glynnis A McDonnell, Madalina Sucala, Rachel E Goldsmith, Guy H Montgomery, Julie B Schnur
Identifying as a 'cancer victim' has been linked to adverse psychosocial sequelae in individuals who have been diagnosed with cancer. Being a childhood sexual abuse (CSA) survivor may predispose individuals towards a "victim" identity in general. The aim of this study was to determine the prevalence of identifying as a 'cancer victim' among CSA survivors who were diagnosed with cancer as adults, and to explore psychological factors associated with identification as a cancer victim. 105 adults reporting both a history of CSA and of having been diagnosed with cancer as an adult were recruited through Amazon Mechanical Turk...
December 2017: Journal of Rational-emotive and Cognitive-behavior Therapy: RET
https://www.readbyqxmd.com/read/29229546/changes-in-cognition-and-dendritic-complexity-following-intrathecal-methotrexate-and-cytarabine-treatment-in-a-juvenile-murine-model
#11
Tyler C Alexander, Christy M Simecka, Frederico Kiffer, Thomas Groves, Julie Anderson, Hannah Carr, Jing Wang, Gwendolyn Carter, Antiño R Allen
Acute lymphoblastic leukemia (ALL) is the most prevalent childhood cancer and accounts for 26.8% of cancer diagnoses among children, worldwide-approximately 3,000 children each year. While advancements in treating ALL have led to a remission rate of more than 90%, many survivors experience adverse neurocognitive and/or neurobehavioral effects as a result of intrathecal chemotherapy. Methotrexate (MTX) is commonly administered with cytosine arabinoside (AraC, cytarabine) during intrathecal chemotherapy for ALL...
December 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29229046/unemployment-following-childhood-cancer
#12
Luzius Mader, Gisela Michel, Katharina Roser
BACKGROUND: Childhood cancer survivors are at risk of physical and mental long-term sequelae that may interfere with their employment situation in adulthood. We updated a systematic review from 2006 and assessed unemployment in adult childhood cancer survivors compared to the general population, and its predictors. METHODS: Systematic literature searches for articles published between February 2006 and August 2016 were performed in CINAHL, EMBASE, PubMed, PsycINFO, and SocINDEX...
November 24, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29228199/new-neoplasm-during-gh-replacement-in-adults-with-pituitary-deficiency-following-malignancy-a-kims-analysis
#13
Katarzyna Krzyzanowska-Mittermayer, Anders F Mattsson, Dominique Maiter, Ulla Feldt-Rasmussen, Cecilia Camacho-Hübner, Anton Luger, Roger Abs
Context: Data on the association between growth hormone (GH) replacement in patients with GH deficiency (GHD) after malignancies and new neoplasms show conflicting results. Objective: To clarify the incidence of new malignant neoplasm in childhood (CO) and adult-onset (AO) adult cancer survivors (CS). Design: Retrospective comparison of CO-CS and AO-CS with CO idiopathic GHD (IGHD) and AO non-functioning pituitary adenoma patients (NFPA) and with the general population (standardized incidence ratio, SIR)...
December 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29222704/healthcare-system-barriers-to-long-term-follow-up-for-adult-survivors-of-childhood-cancer-in-british-columbia-canada-a-qualitative-study
#14
A Fuchsia Howard, Arminee Kazanjian, Sheila Pritchard, Rob Olson, Haroon Hasan, Kelly Newton, Karen Goddard
PURPOSE: Risk-stratified life-long follow-up care is recommended for adult childhood cancer survivors (CCS) to ensure appropriate prevention, screening, and management of late effects. The identification of barriers to long-term follow-up (LTFU), particularly in varying healthcare service contexts, is essential to develop and refine services that are responsive to survivor needs. We aimed to explore CCS and healthcare professionals (HCP) perspectives of healthcare system factors that function as barriers to LTFU in British Columbia, Canada...
December 8, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29207962/a-partially-supervised-physical-activity-program-for-adult-and-adolescent-survivors-of-childhood-cancer-surfit-study-design-of-a-randomized-controlled-trial-nct02730767
#15
Corina S Rueegg, Susi Kriemler, Simeon J Zuercher, Christina Schindera, Andrea Renner, Helge Hebestreit, Christian Meier, Prisca Eser, Nicolas X von der Weid
BACKGROUND: Beyond survival of nowadays >80%, modern childhood cancer treatment strives to preserve long-term health and quality of life. However, the majority of today's survivors suffer from short- and long-term adverse effects such as cardiovascular and pulmonary diseases, obesity, osteoporosis, fatigue, depression, and reduced physical fitness and quality of life. Regular exercise can play a major role to mitigate or prevent such late-effects. Despite this, there are no data on the effects of regular exercise in childhood cancer survivors from randomized controlled trials (RCTs)...
December 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29205290/clinical-impact-of-sedentary-behaviors-in-adult-survivors-of-acute-lymphoblastic-leukemia-a-report-from-the-st-jude-lifetime-cohort-study
#16
Carrie R Howell, Carmen L Wilson, Matthew J Ehrhardt, Robyn E Partin, Sue C Kaste, Jennifer Q Lanctot, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Kirsten K Ness
BACKGROUND: Sedentary behaviors are associated with poor health outcomes in the general population, but their clinical impact on adult survivors of childhood acute lymphoblastic leukemia (ALL) has not been characterized to date. In the current study, we described the prevalence of sedentary behaviors in survivors of ALL and examined associations between time spent sedentary and body composition and onset of cardiovascular disease (CVD) risk factors. METHODS: Participants' self-reported screen time (eg, television, computer) and activity as measured by accelerometer were used to determine activity time (sedentary, light activity, and moderate or vigorous physical activity)...
December 4, 2017: Cancer
https://www.readbyqxmd.com/read/29202445/balancing-the-benefits-and-harms-of-thyroid-cancer-surveillance-in-survivors-of-childhood-adolescent-and-young-adult-cancer-recommendations-from-the-international-late-effects-of-childhood-cancer-guideline-harmonization-group-in-collaboration-with-the-pancaresurfup
#17
REVIEW
S C Clement, L C M Kremer, F A Verburg, J H Simmons, M Goldfarb, R P Peeters, E K Alexander, E Bardi, E Brignardello, L S Constine, C A Dinauer, V M Drozd, F Felicetti, E Frey, A Heinzel, M M van den Heuvel-Eibrink, S A Huang, T P Links, K Lorenz, R L Mulder, S J Neggers, E J M Nieveen van Dijkum, K C Oeffinger, R R van Rijn, S A Rivkees, C M Ronckers, A B Schneider, R Skinner, J D Wasserman, T Wynn, M M Hudson, P C Nathan, H M van Santen
Radiation exposure to the thyroid gland during treatment of childhood, adolescent and young adult cancer (CAYAC) may cause differentiated thyroid cancer (DTC). Surveillance recommendations for DTC vary considerably, causing uncertainty about optimum screening practices. The International Late Effects of Childhood Cancer Guideline Harmonization Group, in collaboration with the PanCareSurFup Consortium, developed consensus recommendations for thyroid cancer surveillance in CAYAC survivors. These recommendations were developed by an international multidisciplinary panel that included 33 experts in relevant medical specialties who used a consistent and transparent process...
November 14, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29198339/patterns-and-drivers-of-health-care-use-in-long-term-childhood-cancer-survivors-a-systematic-review
#18
REVIEW
J van Breeschoten, R De Abreu Lourenco, C Signorelli, M Haas, R J Cohn, C E Wakefield, J E Fardell
BACKGROUND: Childhood cancer survival is increasing. But cancer and treatment late-effects can lead to ongoing health care use. We summarised the literature on the patterns and drivers of health care use among childhood cancer survivors. METHOD: Pubmed, Embase and Medline were searched for studies reporting health care use in childhood cancer survivors. RESULTS: We included 22 studies, covering 88787 experiences of health care use. The proportion of survivors using follow-up care, physician visits, specialist visits, hospitalisations, dental care and screening services varied (36...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29197678/adipokines-inflammation-and-adiposity-in-hematopoietic-cell-transplant-survivors
#19
Tyler G Ketterl, Eric J Chow, Wendy M Leisenring, Pam Goodman, Ildi H Koves, Anna Petryk, Julia Steinberger, K Scott Baker
Adult survivors of acute leukemia in childhood have a higher than expected frequency of obesity, an increased risk for metabolic syndrome and early mortality from cardiovascular disease (CVD). Adipose tissue has been recognized as an endocrine and paracrine organ that secretes various adipokines involved in metabolic regulation and inflammatory processes. Examine inflammatory factors [IL-6 and TNF-] and adipokines (adiponectin, leptin) in addition to body composition and adiposity in cancer survivors who underwent hematopoietic cell transplantation (HCT) during childhood in comparison to sibling controls...
November 29, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29187724/in-depth-insight-into-the-mechanisms-of-cardiac-dysfunction-in-patients-with-childhood-cancer-after-anthracycline-treatment-using-layer-specific-strain-analysis
#20
Kana Yazaki, Ken Takahashi, Sachie Shigemitsu, Mariko Yamada, Takeshi Iso, Maki Kobayashi, Katsumi Akimoto, Hiroyuki Tamaichi, Junya Fujimura, Masahiro Saito, Masaki Nii, Toshiaki Shimizu
BACKGROUND: Anthracycline cardiotoxicity affects clinical outcomes, and its early detection using methods that rely on conventional echocardiography, such as left ventricular ejection fraction (LVEF) is difficult. This study aimed to evaluate the characteristics and the differences in cardiac dysfunction among childhood cancer survivors in 3 age groups using layer-specific strain analysis in a wide age range.Methods and Results:The 56 patients (median age: 15 [range: 6.8-40.2] years) who had been treated with anthracycline for childhood cancer were divided into 3 age groups (C1: 6-12 years, C2: 13-19 years, C3: 20-40 years) after anthracycline treatment, and 72 controls of similar ages were divided into 3 corresponding groups (N1, N2, and N3)...
November 29, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
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