keyword
MENU ▼
Read by QxMD icon Read
search

Survivors of childhood cancer

keyword
https://www.readbyqxmd.com/read/29772082/child-symptoms-parent-behaviors-and-family-strain-in-long-term-survivors-of-childhood-acute-lymphoblastic-leukemia
#1
I-Chan Huang, Tara M Brinkman, Larry Mullins, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: How family environment and parental factors affect health status and symptoms in childhood cancer survivors is understudied. We examined the influence of family cohesion, parent distress, and overprotection on child symptom burden and health-related quality of life (HRQOL) and family strain in survivors of childhood acute lymphoblastic leukemia (ALL). METHODS: Parents of 213 children treated with chemotherapy-only completed a survey when survivors were at least five-years post-diagnosis...
May 17, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29771337/randomized-trial-of-the-impact-of-empowering-childhood-cancer-survivors-with-survivorship-care-plans
#2
Nina S Kadan-Lottick, Wilhelmenia L Ross, Hannah-Rose Mitchell, Jaime Rotatori, Cary P Gross, Xiaomei Ma
Background: A survivorship care plan (SCP), that is, individualized treatment summary and schedule of off-therapy surveillance, will be mandated by January 2019. It is unclear whether SCPs improve adherence to recommended follow-up care in the community. In this trial, we evaluated the impact of randomly assigning childhood cancer survivors to 1) SCPs to be taken to their primary care physician (PCP) to implement or 2) survivorship clinic (SC) on health care quality measures. Methods: Eligibility included cancer diagnosis younger than age 18 years (2000-2012), cancer free, one or more years off therapy, and no prior survivorship clinic attendance...
May 15, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29769170/design-and-rationale-for-a-parent-led-intervention-to-increase-fruit-and-vegetable-intake-in-young-childhood-cancer-survivors-reboot-protocol-for-a-pilot-study
#3
Lauren Touyz, Jennifer Cohen, Claire Wakefield, Allison Grech, Sarah Garnett, Paayal Gohil, Richard Cohn
BACKGROUND: Poor dietary habits are common among childhood cancer survivors, despite increasing their risk of cardio metabolic complications after cancer treatment. Here, we describe the design and rationale for a pilot telephone-based, parent-led intervention aimed at increasing fruit and vegetable intake in young cancer survivors (Reboot). OBJECTIVE: This pilot study aims to assess the feasibility and acceptability of delivering evidence-based telephone support to parents of childhood cancer survivors...
May 16, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29768076/depressive-symptoms-and-quality-of-life-among-adolescent-and-young-adult-cancer-survivors-impact-of-gender-and-latino-culture
#4
Anamara Ritt-Olson, Kimberly Miller, Lourdes Baezconde-Garbanati, David Freyer, Cynthia Ramirez, Ann Hamilton, Joel Milam
Ethnic and sex variations in depressive symptoms and quality of life (QOL) among adolescent and young adult (AYA) childhood cancer survivors were explored among a sample of Latino and non-Latino childhood cancer survivors (CCSs) (n = 194) treated at hospitals in Los Angeles County. Latinos scored higher in depressive symptoms and lower in QOL when compared with non-Latinos. Males had higher depressive symptoms. Among Latinos, higher levels of acculturation were associated with depression and a poorer QOL, and we found that more acculturated Latino males were more likely to have meaningful levels of depression than less acculturated males or females...
May 16, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29764843/poorly-cytotoxic-terminally-differentiated-cd56-neg-cd16-pos-nk-cells-accumulate-in-kenyan-children-with-burkitt-lymphomas
#5
Catherine S Forconi, Cormac P Cosgrove, Pryia Saikumar-Lakshmi, Christina E Nixon, Joslyn Foley, John Michael Ong'echa, Juliana A Otieno, Galit Alter, Christian Münz, Ann M Moormann
Natural killer (NK) cells are critical for restricting viral infections and mediating tumor immunosurveillance. Epstein-Barr virus (EBV) and Plasmodium falciparum malaria are known risk factors for endemic Burkitt lymphoma (eBL), the most common childhood cancer in equatorial Africa. To date, the composition and function of NK cells have not been evaluated in eBL etiology or pathogenesis. Therefore, using multiparameter flow cytometry and in vitro killing assays, we compared NK cells from healthy children and children diagnosed with eBL in Kenya...
May 22, 2018: Blood Advances
https://www.readbyqxmd.com/read/29763379/hypothyroidism-after-radiation-therapy-for-childhood-cancer-a-report-from-the-childhood-cancer-survivor-study
#6
Peter D Inskip, Lene H S Veiga, Alina V Brenner, Alice J Sigurdson, Evgenia Ostroumova, Eric J Chow, Marilyn Stovall, Susan A Smith, Rita E Weathers, Wendy Leisenring, Leslie L Robison, Gregory T Armstrong, Charles A Sklar, Jay H Lubin
While thyroid cancer risks from exposure to ionizing radiation early in life are well characterized quantitatively, the association of radiation with nonmalignant, functional thyroid disorders has been less studied. Here, we report on a risk analysis study of hypothyroidism with radiation dose to the thyroid gland and the hypothalamic-pituitary axis among survivors of childhood cancer. Utilizing data from the Childhood Cancer Survivor Study, a cohort of 14,364 five-year survivors of childhood cancer diagnosed at 26 hospitals in the U...
May 15, 2018: Radiation Research
https://www.readbyqxmd.com/read/29759558/the-influence-of-genetic-variation-on-late-toxicities-in-childhood-cancer-survivors-a-review
#7
REVIEW
E Clemens, A L F van der Kooi, L Broer, E van Dulmen-den Broeder, H Visscher, L Kremer, W Tissing, J Loonen, C M Ronckers, S M F Pluijm, S J C M M Neggers, O Zolk, T Langer, A Am Zehnhoff-Dinnesen, C L Wilson, M M Hudson, B Carleton, J S E Laven, A G Uitterlinden, M M van den Heuvel-Eibrink
INTRODUCTION: The variability in late toxicities among childhood cancer survivors (CCS) is only partially explained by treatment and baseline patient characteristics. Inter-individual variability in the association between treatment exposure and risk of late toxicity suggests that genetic variation possibly modifies this association. We reviewed the available literature on genetic susceptibility of late toxicity after childhood cancer treatment related to components of metabolic syndrome, bone mineral density, gonadal impairment and hearing impairment...
June 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29757114/intolerance-of-uncertainty-as-the-vulnerability-factor-among-parents-of-childhood-cancer-survivors-a-3-month-follow-up-study
#8
Marie Vander Haegen, Anne-Marie Etienne
PURPOSE: In a 3-month follow-up study, we assessed the intolerance of uncertainty in 61 parents of a childhood cancer survivor. The objective was to compare its prevalence over time. We tested these parents twice i.e., at treatment completion (time 1) and 3 months later (time 2). We hypothesized that this personality factor stayed stable and had aversive effects on cognitive processes. FINDINGS: Noticeable intolerance of uncertainty rates were found. At both assessments, results showed that this factor was central in the development of excessive worries, poor problem orientation, rumination, cognitive avoidance and positive beliefs about worry...
May 14, 2018: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/29756230/the-relationship-between-pulmonary-artery-wedge-pressure-and-pulmonary-blood-volume-derived-from-contrast-echocardiography-a-proof-of-concept-study
#9
Ken Monahan, Daniel Lenihan, Evan L Brittain, Linda Saliba, Robert N Piana, Leslie L Robison, Melissa M Hudson, Gregory T Armstrong
BACKGROUND: Pulmonary transit time (PTT) obtained from contrast echocardiography is a marker of global cardiopulmonary function. Pulmonary blood volume (PBV), derived from PTT, may be a noninvasive surrogate for left-sided filling pressures, such as pulmonary artery wedge pressure (PAWP). We sought to assess the relationship between PBV obtained from contrast echocardiography and PAWP. METHODS: Participants were adult survivors of childhood cancer that had contrast echocardiography performed nearly simultaneously with right-heart catheterization...
May 14, 2018: Echocardiography
https://www.readbyqxmd.com/read/29748251/respiratory-mortality-of-childhood-adolescent-and-young-adult-cancer-survivors
#10
Miranda M Fidler, Raoul C Reulen, Chloe J Bright, Katherine E Henson, Julie S Kelly, Meriel Jenney, Antony Ng, Jeremy Whelan, David L Winter, Clare Frobisher, Michael M Hawkins
BACKGROUND: Exposure to radiation and/or chemotherapy during cancer treatment can compromise respiratory function. We investigated the risk of long-term respiratory mortality among 5-year cancer survivors diagnosed before age 40 years using the British Childhood Cancer Survivor Study (BCCSS) and Teenage and Young Adult Cancer Survivor Study (TYACSS). METHODS: The BCCSS comprises 34 489 cancer survivors diagnosed before 15 years from 1940 to 2006 in Great Britain...
May 10, 2018: Thorax
https://www.readbyqxmd.com/read/29742278/conditional-relative-survival-among-long-term-survivors-of-adolescent-and-young-adult-cancers
#11
Chelsea Anderson, Andrew B Smitherman, Hazel B Nichols
BACKGROUND: Many studies have examined long-term outcomes after childhood cancer, but few address outcomes for adolescent and young adult (AYA; those aged 15-39 years) cancer survivors. Conditional survival reflects changing mortality risk with time since cancer diagnosis and is a useful measure for planning long-term follow-up care. METHODS: Using the Surveillance, Epidemiology, and End Results registry 9 database, the authors identified a cohort of AYA patients diagnosed with a first malignant cancer between 1973 and 2009 and followed through 2014...
May 9, 2018: Cancer
https://www.readbyqxmd.com/read/29740904/falling-through-the-cracks-a-thematic-evaluation-of-unmet-needs-of-adult-survivors-of-childhood-cancers
#12
Jennifer White, Joanne Park, K Brooke Russell, K A Reynolds, A Madani, Linda E Carlson, Janine Giese-Davis
BACKGROUND: The population of adult survivors of childhood cancers (ASCCs) is growing, resulting in unique long-term challenges. This study explored experiences of perceived unmet ASCC survivorship needs. METHODS: We invited ASCCs to complete surveys sent through the cancer registry. Four open-ended questions allowed participants to write in comments. We analyzed responses to these open-ended questions thematically, employing a process of constant comparison. RESULTS: Our sample included 94 ASCCs who completed open-ended questions (61 female; aged 20-78 years, mean age=34...
May 8, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29734694/hearing-loss-in-adult-survivors-of-childhood-cancer-treated-with-radiotherapy
#13
Amber Khan, Amy Budnick, Dana Barnea, Darren R Feldman, Kevin C Oeffinger, Emily S Tonorezos
The ototoxic effects of radiotherapy have been poorly characterized. We examined adult survivors of childhood cancer who were treated with radiotherapy, which included the head, before the age of 22 years and between 1952 and 2016. Those who received platinum chemotherapy were excluded. Demographic, diagnosis, and treatment outcomes were captured. Audiograms were graded using the Chang and International Society of Paediatric Oncology ototoxicity (SIOP) scales. Among 276 patients with a history of radiation to sites that included the brain, orbit, nasopharynx, and total body irradiation, the median age at treatment was 10...
May 4, 2018: Children
https://www.readbyqxmd.com/read/29730064/risk-of-radiation-vasculopathy-and-stroke-in-pediatric-patients-treated-with-proton-therapy-for-brain-and-skull-base-tumors
#14
Matthew D Hall, Julie A Bradley, Ronny L Rotondo, Ricardo Hanel, Chetan Shah, Christopher G Morris, Philipp R Aldana, Daniel J Indelicato
PURPOSE: To estimate the rate of and identify risk factors for vasculopathy after proton therapy in pediatric patients with central nervous system and skull base tumors. METHODS AND MATERIALS: Between 2006 and 2015, 644 pediatric patients with central nervous system and skull base tumors were treated with proton therapy at a single institution. The 3 most common histologies were craniopharyngioma (n = 135), ependymoma (n = 135), and low-grade glioma (n = 131)...
March 29, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29722481/randomized-web-based-physical-activity-intervention-in-adolescent-survivors-of-childhood-cancer
#15
Carrie R Howell, Kevin R Krull, Robyn E Partin, Nina S Kadan-Lottick, Leslie L Robison, Melissa M Hudson, Kirsten K Ness
BACKGROUND: Healthy lifestyle choices, including participation in regular physical activity, may improve health outcomes in survivors of childhood cancer. We aimed to evaluate the efficacy of a web-delivered physical activity intervention among adolescent survivors to increase moderate to vigorous physical activity (MVPA) and improve fitness and neurocognitive and health-related quality of life (HRQoL) over 24 weeks. PROCEDURE: This randomized controlled trial was conducted among survivors (aged ≥11 to <15 years) treated at a single institution...
May 3, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29713910/employment-status-and-termination-among-survivors-of-pediatric-brain-tumors-a-cross-sectional-survey
#16
Iori Sato, Akiko Higuchi, Takaaki Yanagisawa, Shiho Murayama, Toshihiro Kumabe, Kazuhiko Sugiyama, Akitake Mukasa, Nobuhito Saito, Yutaka Sawamura, Mizuhiko Terasaki, Soichiro Shibui, Jun Takahashi, Ryo Nishikawa, Yasushi Ishida, Kiyoko Kamibeppu
BACKGROUND: Some childhood cancer survivors experience employment difficulties. This study aimed to describe pediatric brain-tumor survivors' employment status. METHODS: A cross-sectional, observational study was conducted, with questionnaires distributed to 101 pediatric brain-tumor survivors (aged 15 years or older) and their attending physicians from nine institutions in Japan. We compared category and time-series histories for participants' first-time employment using national census information...
April 30, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29713898/pharmacogenetics-of-chemotherapy-induced-cardiotoxicity
#17
REVIEW
Vivian Y Chang, Jessica J Wang
PURPOSE OF REVIEW: The goal of this review is to summarize current understanding of pharmacogenetics and pharmacogenomics in chemotherapy-induced cardiotoxicity. RECENT FINDINGS: Most of the studies rely on in vitro cytotoxic assays. There have been several smaller scale candidate gene approaches and a handful of genome-wide studies linking genetic variation to susceptibility to chemotherapy-induced cardiotoxicity. Currently, pharmacogenomic testing of all childhood cancer patients with an indication for doxorubicin or daunorubicin therapy for RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4 rs17863783 variants is recommended...
April 30, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29708940/chronic-pain-in-survivors-of-childhood-cancer-a-developmental-model-of-pain-across-the-cancer-trajectory
#18
Nicole M Alberts, Michelle M Gagnon, Jennifer N Stinson
No abstract text is available yet for this article.
April 26, 2018: Pain
https://www.readbyqxmd.com/read/29703501/heart-volume-reduction-during-radiotherapy-involving-the-thoracic-region-in-children-an-unexplained-phenomenon
#19
Irma W E M van Dijk, Jorrit Visser, Jan Wiersma, Jessica R van Boggelen, Brian V Balgobind, Elizabeth A M Lieke Feijen, Sophie C Huijskens, Wouter E M Kok, Leontien C M Kremer, Coen R N Rasch, Arjan Bel
BACKGROUND AND PURPOSE: Radiotherapy involving the thoracic region is associated with cardiotoxicity in long-term childhood cancer survivors. We quantified heart volume changes during radiotherapy in children (<18 years) and investigated correlations with patient and treatment related characteristics. MATERIAL AND METHODS: Between 2010 and 2016, 34 children received radiotherapy involving the thoracic region. We delineated heart contours and measured heart volumes on 114 CBCTs...
April 24, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29700907/psychosexual-development-and-satisfaction-with-timing-of-developmental-milestones-among-adult-survivors-of-childhood-cancer
#20
Vicky Lehmann, Madelaine C Keim, Amanda C Ferrante, Randal S Olshefski, Cynthia A Gerhardt
OBJECTIVE: To extend the limited research on psychosexual development among childhood cancer survivors, by not only focusing on the prevalence and age of milestone attainment, but also survivors- attitudes toward the timing of reaching such milestones. METHODS: Adult survivors of childhood cancer (N=90; Mage =29.8, SD=5.2), recruited from a U.S. pediatric institution, completed online surveys indicating whether they had reached five milestones of psychosexual development (i...
April 27, 2018: Psycho-oncology
keyword
keyword
50854
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"