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Merkel cell carcinoma

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https://www.readbyqxmd.com/read/27925665/viral-oncoprotein-antibodies-as-a-marker-for-recurrence-of-merkel-cell-carcinoma-a-prospective-validation-study
#1
Kelly G Paulson, Christopher W Lewis, Mary W Redman, William T Simonson, Aaron Lisberg, Deborah Ritter, Chihiro Morishima, Kathleen Hutchinson, Lola Mudgistratova, Astrid Blom, Jayasri Iyer, Ata S Moshiri, Erica S Tarabadkar, Joseph J Carter, Shailender Bhatia, Masaoki Kawasumi, Denise A Galloway, Mark H Wener, Paul Nghiem
BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive skin cancer with a recurrence rate of >40%. Of the 2000 MCC cases per year in the United States, most are caused by the Merkel cell polyomavirus (MCPyV). Antibodies to MCPyV oncoprotein (T-antigens) have been correlated with MCC tumor burden. The present study assesses the clinical utility of MCPyV-oncoprotein antibody titers for MCC prognostication and surveillance. METHODS: MCPyV-oncoprotein antibody detection was optimized in a clinical laboratory...
December 7, 2016: Cancer
https://www.readbyqxmd.com/read/27919405/merkel-cell-carcinoma-an-update-of-key-imaging-techniques-prognostic-factors-treatment-and-follow-up
#2
B Llombart, S Kindem, M Chust
Merkel cell carcinoma, though rare, is one of the most aggressive tumors a dermatologist faces. More than a third of patients with this diagnosis die from the disease. Numerous researchers have attempted to identify clinical and pathologic predictors to guide prognosis, but their studies have produced inconsistent results. Because the incidence of Merkel cell carcinoma is low and it appears in patients of advanced age, prospective studies have not been done and no clear treatment algorithm has been developed...
December 2, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27880818/merkel-cell-polyomavirus-small-t-antigen-promotes-pro-glycolytic-metabolic-perturbations-required-for-transformation
#3
Christian Berrios, Megha Padi, Mark A Keibler, Donglim Esther Park, Vadim Molla, Jingwei Cheng, Soo Mi Lee, Gregory Stephanopoulos, John Quackenbush, James A DeCaprio
Merkel cell polyomavirus (MCPyV) is an etiological agent of Merkel cell carcinoma (MCC), a highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is required for maintenance of MCC and can transform normal cells. To gain insight into cellular perturbations induced by MCPyV ST, we performed transcriptome analysis of normal human fibroblasts with inducible expression of ST. MCPyV ST dynamically alters the cellular transcriptome with increased levels of glycolytic genes, including the monocarboxylate lactate transporter SLC16A1 (MCT1)...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27879975/metastatic-merkel-cell-carcinoma-response-to-nivolumab
#4
Frances M Walocko, Benjamin Y Scheier, Paul W Harms, Leslie A Fecher, Christopher D Lao
BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine malignancy with limited treatment options. Several lines of evidence support the programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) axis as a likely contributor to immune evasion in MCC. CASE PRESENTATION: We report a case of a patient with metastatic MCC with a significant and durable response to nivolumab, a humanized IgG4 monoclonal anti-PD-1 antibody. CONCLUSION: Immunotherapy with PD-1/PD-L1 inhibitors has become a rational and promising treatment option for MCC in the advanced or metastatic disease...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27878368/-therapy-options-for-malignant-eyelid-tumors
#5
M Weiling, A Bergua, F E Kruse, L Holbach
Basal cell carcinomas are the most common malignant tumors of the eyelids. Patient history, clinical symptoms and signs, inspection, palpation and slit-lamp examination usually allow a working diagnosis; however, the clinical diagnosis requires histopathological confirmation and determination of the histopathological type. Squamous cell carcinomas, sebaceous gland carcinomas, melanomas and Merkel cell carcinomas can metastasize usually via the lymph vessels into the regional lymph nodes. Microscopically controlled excision of the primary tumor into healthy tissue is most commonly the first goal...
November 22, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27856777/virus-related-merkel-cell-carcinoma-complicating-fingolimod-treatment-for-multiple-sclerosis
#6
Heidi N Beadnall, Anthony J Gill, Sean Riminton, Michael H Barnett
No abstract text is available yet for this article.
November 16, 2016: Neurology
https://www.readbyqxmd.com/read/27832373/human-polyomavirus-and-human-papillomavirus-prevalence-and-viral-load-in-non-malignant-tonsillar-tissue-and-tonsillar-carcinoma
#7
Stephan Herberhold, Martin Hellmich, Marcus Panning, Eva Bartok, Steffi Silling, Baki Akgül, Ulrike Wieland
Human papillomaviruses (HPVs) are an acknowledged cause of a subset of oropharyngeal cancers, especially of tonsillar cancer. Similar to HPV, some human polyomaviruses (HPyVs), such as Merkel cell polyomavirus (MCPyV), have an oncogenic potential. Recently, several novel HPyVs have been discovered. The aim of our study was to determine viral DNA prevalence and viral DNA load of 13 different HPyVs in benign and malignant tonsillar tissue and to compare the data with those found for HPV. A total of 78 biopsies of palatine tonsils with a histologic diagnosis of non-malignant disease (chronic tonsillitis, tonsillar hyperplasia, n = 40) or tonsillar squamous cell carcinoma (n = 38) were included in the study...
November 10, 2016: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/27815175/polyomavirus-negative-merkel-cell-carcinoma-a-more-aggressive-subtype-based-on-analysis-of-282-cases-using-multi-modal-tumor-virus-detection
#8
Ata Moshiri, Ryan Doumani, Lola Yelistratova, Astrid Blom, Kristina Lachance, Michi M Shinohara, Martha Delaney, Oliver Chang, Susan McArdle, Hannah Thomas, Maryam M Asgari, Meei-Li Huang, Stephen M Schwartz, Paul Nghiem
Previous studies have reached conflicting conclusions regarding the proportion of Merkel cell carcinomas (MCCs) that contain the Merkel cell polyomavirus (MCPyV) and the clinical significance of tumor viral status. To address these controversies, we detected MCPyV large T antigen using immunohistochemistry with two distinct antibodies and MCPyV DNA using quantitative PCR. Tumors were called MCPyV-positive if two or more of these three assays indicated presence of this virus. 53 of 282 (19%) MCC tumors in this cohort were virus-negative using this multimodal system...
November 1, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27814751/recurrent-merkel-cell-carcinoma-of-the-testis-with-unknown-primary-site-a-case-report
#9
Angela Mweempwa, Alvin Tan, Michael Dray
BACKGROUND: Merkel cell carcinoma is a rare and aggressive neuroendocrine tumor that commonly arises in the skin. It is rare for it to occur in the testes. There are only seven cases of testicular Merkel cell carcinoma reported in the literature. CASE PRESENTATION: A 66-year-old Maori man presented to our hospital with left testicular swelling. His alpha-fetoprotein and beta-human chorionic gonadotrophin levels were within normal limits. His lactate dehydrogenase concentration was elevated to 267 U/L...
November 5, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27782080/in-vitro-and-in-vivo-models-for-the-study-of-human-polyomavirus-infection
#10
REVIEW
Heidi Barth, Morgane Solis, Wallys Kack-Kack, Eric Soulier, Aurélie Velay, Samira Fafi-Kremer
Developments of genome amplification techniques have rapidly expanded the family of human polyomaviruses (PyV). Following infection early in life, PyV persist in their hosts and are generally of no clinical consequence. High-level replication of PyV can occur in patients under immunosuppressive or immunomodulatory therapy and causes severe clinical entities, such as progressive multifocal leukoencephalopathy, polyomavirus-associated nephropathy or Merkel cell carcinoma. The characterization of known and newly-discovered human PyV, their relationship to human health, and the mechanisms underlying pathogenesis remain to be elucidated...
October 22, 2016: Viruses
https://www.readbyqxmd.com/read/27778198/left-sided-laterality-of-merkel-cell-carcinoma-in-a-german-population-more-than-just-sun-exposure
#11
T Gambichler, U Wieland, S Silling, M Dreißigacker, J Schaller, H-J Schulze, F Oellig, A Kreuter, M Stücker, F G Bechara, E Stockfleth, J C Becker
BACKGROUND: Lateral distribution of cancer has been observed previously. Most evident is this laterality in ultraviolet (UV)-induced skin cancer, based on an unequally distributed UV exposure. OBJECTIVES: The aim of this study was to explore whether patients from Germany also show asymmetrical lateral distribution of Merkel cell carcinoma (MCC). METHODS: In total, 115 patients with MCC were studied for laterality of the primary tumour. Correlation of clinical variables with lateral distribution of MCC was investigated as well...
October 24, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27777334/secondary-merkel-cell-carcinoma-arising-from-a-graft-donor-site
#12
Fatima Aloraifi, Stephen Mulgrew, Nick K James
Merkel cell carcinoma (MCC) is a highly aggressive cutaneous neuroendocrine tumour that is increasing in incidence. We report a case of a 92-year-old white man on long-term immunosuppression for temporal arteritis who presented with a Merkel cell tumour on his left cheek. A wide local excision was performed and the defect was reconstructed with a full-thickness skin graft. Four years later, the patient re-presented with a Merkel cell tumour arising from the right supraclavicular donor site. To our knowledge, this is the first report of a recurrence of MCC into a donor site...
October 24, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27774637/presence-of-the-merkel-cell-polyomavirus-in-merkel-cell-carcinoma-combined-with-squamous-cell-carcinoma-in-a-patient-with-chronic-arsenism
#13
T-C Chou, K-B Tsai, C-Y Wu, C-H Hong, C-H Lee
We present a case of Merkel cell carcinoma (MCC) coincident with squamous cell carcinoma (SCC) on the breast of a woman with chronic arsenism. This case demonstrates the distinct association of chronic arsenism with two different primary cutaneous carcinomas. Merkel cell polyomavirus (MCPyV) was identified in the lesional skin of the MCC but not in that of the SCC, suggesting there are different interactions of MCPyV in the pathogenesis of SCC and MCC related to arsenic. Physicians need to be vigilant in the occurrence of both SCC and MCC in patients with chronic arsenism...
October 23, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27772941/clinicopathological-spectrum-of-a-series-of-merkel-cell-carcinomas-diagnosed-at-a-tertiary-cancer-referral-centre-india
#14
Bharat Rekhi, Shubada V Kane, Nirmala A Jambhekar
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27770997/update-on-merkel-cell-carcinoma-epidemiology-etiopathogenesis-clinical-features-diagnosis-and-staging
#15
B Llombart, C Requena, J Cruz
Merkel cell carcinoma (MCC) is a rare, highly aggressive tumor, and local or regional disease recurrence is common, as is metastasis. MCC usually develops in sun-exposed skin in patients of advanced age. Its incidence has risen 4-fold in recent decades as the population has aged and immunohistochemical techniques have led to more diagnoses. The pathogenesis of MCC remains unclear but UV radiation, immunosuppression, and the presence of Merkel cell polyomavirus in the tumor genome seem to play key roles. This review seeks to update our understanding of the epidemiology, etiology, pathogenesis, and clinical features of MCC...
October 19, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27768129/nursing-management-of-advanced-merkel-cell-carcinoma
#16
Pamela A Lowry, Morganna L Freeman, Jeffery S Russell
Merkel cell carcinoma (MCC) is a rare and lethal skin cancer with few known treatment options. Management of this disease is challenging, and oncology nurses must understand the medical, physical, and psychosocial burden that MCC places on the patient and family caregivers. Patients must navigate a complex medical and insurance network that often fails to support patients with rare cancers. Nurses must advocate for these patients to ensure quality comprehensive cancer care.
November 1, 2016: Oncology Nursing Forum
https://www.readbyqxmd.com/read/27765804/cerebral-metastases-from-merkel-cell-carcinoma-long-term-survival
#17
S Honeybul
Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumour that is locally aggressive. In most cases the primary treatment is local surgical excision; however, there is a high incidence recurrence both local and distant. Cerebral metastases from Merkel cell carcinoma are extremely uncommon with only 12 cases published in the literature. This case is particularly unusual in that, not only was no established primary lesion identified, but also the patient has survived for 10 years following initial diagnosis and for 9 years following excision of a single brain metastasis...
October 7, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27759689/complete-spontaneous-regression-of-merkel-cell-carcinoma-after-biopsy-a-case-report-and-review-of-the-literature
#18
Parnian Ahmadi Moghaddam, Kristine M Cornejo, Lloyd Hutchinson, Keith Tomaszewicz, Karen Dresser, April Deng, Patrick OʼDonnell
Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine tumor that typically occurs on the head and neck of the elderly and follows an aggressive clinical course. Merkel cell polyomavirus (MCPyV) has been identified in up to 80% of cases and has been shown to participate in MCC tumorigenesis. Complete spontaneous regression of MCC has been rarely reported in the literature. We describe a case of a 79-year-old man that presented with a rapidly growing, 3-cm mass on the left jaw. An incisional biopsy revealed MCC...
November 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27758029/intraepidermal-merkel-cell-carcinoma-with-pagetoid-bowen-s-disease
#19
Allen P Miraflor, Philip E LeBoit, Scott A Hirschman
No abstract text is available yet for this article.
November 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27741405/transgenic-mouse-models-of-tumor-virus-action
#20
Paul F Lambert
Genetically engineered mice (GEMs) have provided valuable insights into the carcinogenic properties of various human tumor viruses, which, in aggregate, are etiologically associated with over 15% of all human cancers. This review provides an overview of seminal discoveries made through the use of GEM models for human DNA tumor viruses. Emphasis is placed on the discoveries made in the study of human papillomaviruses, Merkel cell carcinoma-associated polyomavirus, Epstein-Barr virus, and Kaposi's sarcoma-associated herpesvirus, because GEMs have contributed extensively to our understanding of how these DNA tumor viruses directly contribute to human cancers...
September 29, 2016: Annual Review of Virology
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