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Merkel cell carcinoma

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https://www.readbyqxmd.com/read/28212766/a-population-based-cohort-study-on-the-association-of-dermatologist-density-and-merkel-cell-carcinoma-survival
#1
Maressa C Criscito, Kathryn J Martires, Jennifer A Stein
No abstract text is available yet for this article.
March 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28194491/-merkel-cell-carcinoma-cutaneous-manifestation-of-a-highly-malignant-pre-pro-b%C3%A2-cell-neoplasia-novel-concept-about-the-cellular-origin-of-merkel-cell-carcinoma
#2
REVIEW
C M Sauer, E Chteinberg, D Rennspiess, A K Kurz, A Zur Hausen
Merkel cell carcinoma (MCC) is a relatively rare but highly malignant non-melanoma skin cancer of the elderly and immunosuppressed patients. The discovery of the Merkel cell polyomavirus (MCPyV) in 2008 significantly impacted the understanding of the etiopathogenesis of MCC. MCPyV is clonally integrated into the MCC genome and approximately 80% of MCC are MCPyV-positive. Recent results of clinical trials using blockade of the PD-1 immune modulatory pathway are promising for the future treatment of MCC. Despite this major progress of the past few years, the cellular origin of MCC still remains obscure...
February 13, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28191812/moderately-differentiated-neuroendocrine-cell-carcinoma-of-the-vulva-a-case-report-and-review-of-the-literature
#3
Soheila Aminimoghaddam, A Maghsoudnia, S Shafiee
Primary vulvar neuroendocrine carcinoma are extremely rare. There have been few cases of these tumors most of which have been considered as Merkel cell carcinoma. This report describes a moderately differentiated neuroendocrine cell carcinoma that was not compatible to any of previously reported cases. The patient underwent left hemivulvectomy and bilateral inguinal lymph node dissection. Pathology examination revealed a 5×5 cm mass with no lymph node involvement. Post-op evaluation ruled out any regional and distant metastasis and thereby did not receive chemotherapy or radiotherapy...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28178716/invasive-haemophilus-influenzae-infection-in-patients-with-cancer
#4
Vivek Singh, Sowmya Nanjappa, Smitha Pabbathi, John N Greene
A major cause of morbidity and mortality in patients with cancer is infection. Since the introduction of the Haemophilus influenzae type b (Hib) vaccine in the United States in the 1990s, invasive H influenzae infection has become less common. We report on 5 patients with cancer and invasive H influenzae infection. A literature review was also performed of the dominant Haemophilus subtype and the clinical features associated with the infection and concomitant cancer. Of the 17 cases found in the literature, had hematological malignancies and 1 case each had thymoma, schwannoma, teratoma, and pancreatic, Merkel cell, pharyngeal, laryngeal, and rectal carcinomas...
January 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28174236/merkel-cell-carcinomas-arising-in-autoimmune-disease-affected-patients-treated-with-biological-drugs-including-tnf
#5
John C Rotondo, Ilaria Bononi, Andrea Puozzo, Marcello Govoni, Valentina Foschi, Giovanni Lanza, Roberta Gafà, Antoine Touzè, Pauline Gaboriaud, Rita Selvatici, Fernanda Martini, Mauro Tognon
PURPOSE: The purpose of this investigation was to characterize Merkel cell carcinomas (MCC) arising in patients affected by auto-immune diseases, treated with biologic drugs. EXPERIMENTAL DESIGN: Serum samples from MCC patients were analyzed for the presence and titer of antibodies against antigens of the oncogenic Merkel cell polyomavirus (MCPyV). IgG antibodies against the viral oncoproteins Large T (LT) and small t (ST) antigens and the viral capsid protein 1 were analyzed by indirect E...
February 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28149222/merkel-cell-carcinoma-of-the-hand-a-case-report-and-review-of-the-literature
#6
Donevan R Westerveld, David J Hall, Winston T Richards
Background: Merkel cell carcinoma (MCC) is a relatively rare and aggressive cutaneous neuroendocrine malignancy characterized by high incidence of local recurrence, distant metastases, regional nodal metastases, and high mortality. Clinically, MCC presents as a persistent asymptomatic red/pink shaped nodule, usually smaller than 2 cm with nontender intracutaneous swelling, with rapidly growing localized disease with lymph node metastases preceding distant metastases. Because of its rare nature and the lack of comprehensive understanding of the disease, management of MCC has been controversial...
December 2016: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28143624/merkel-cell-carcinoma-occurring-in-a-black-woman-a-case-report
#7
Selma Kadiri, Abdellah Aissa, Soufiane Berhili, Mouna Khmou, Sanaa Elmajjaoui, Tayeb Kebdani, Basma El Khannoussi, Hanan Elkacemi, Noureddine Benjaafar
BACKGROUND: Merkel cell carcinoma is a rare, very aggressive neuroectodermal tumor of the skin. It is typically located on sun-exposed skin and frequently found in white men aged between 70 and 80 years. CASE PRESENTATION: We report a case of a 58-year-old black woman diagnosed with Merkel cell carcinoma of the posterior face of the right elbow. She had biopsy excision and was lost to follow-up. Four months later, she presented with recurrent disease on the inferior third of the right arm with three ipsilateral axillary lymph node metastases...
January 31, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28138393/clinical-features-and-treatment-of-vulvar-merkel-cell-carcinoma-a-systematic-review
#8
REVIEW
Austin Huy Nguyen, Ahmed I Tahseen, Adam M Vaudreuil, Gabriel C Caponetti, Christopher J Huerter
BACKGROUND: Merkel cell carcinoma is a rare and aggressive neoplasm originating from mechanoreceptor Merkel cells of the stratum basale of the epidermis. Cases affecting the vulva are exceedingly rare, with the currently available literature primarily in case report form. BODY: Systematic review of the PubMed database returned 17 cases of Merkel cell carcinoma affecting the vulva. Patients presented at a mean age of 59.6 years with a firm, mobile vulvar mass. Symptoms of pain, erythema, pruritus, edema, and ulceration have been reported...
2017: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/28130073/hedgehog-signaling-inhibitors-fail-to-reduce-merkel-cell-carcinoma-viability
#9
Thomas M Carroll, Jonathan S Williams, Kenneth Daily, Tova Rogers, Tara Gelb, Amy Coxon, Steven Q Wang, Aimee M Crago, Klaus J Busam, Isaac Brownell
No abstract text is available yet for this article.
January 24, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28128848/head-and-neck-cancers-major-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#10
William M Lydiatt, Snehal G Patel, Brian O'Sullivan, Margaret S Brandwein, John A Ridge, Jocelyn C Migliacci, Ashley M Loomis, Jatin P Shah
Answer questions and earn CME/CNE The recently released eighth edition of the American Joint Committee on Cancer (AJCC) Staging Manual, Head and Neck Section, introduces significant modifications from the prior seventh edition. This article details several of the most significant modifications, and the rationale for the revisions, to alert the reader to evolution of the field. The most significant update creates a separate staging algorithm for high-risk human papillomavirus-associated cancer of the oropharynx, distinguishing it from oropharyngeal cancer with other causes...
January 27, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28121080/unusual-merkel-cell-carcinoma-a-great-chameleon
#11
Francesca Peccerillo, Calogero Pagliarello, Fabio Zambito Spadaro, Roberto Ricci, Claudio Feliciani, Giuseppe Fabrizi
No abstract text is available yet for this article.
January 24, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28117886/hepatitis-c-virus-infection-and-the-risk-of-cancer-among-elderly-us-adults-a-registry-based-case-control-study
#12
Parag Mahale, Harrys A Torres, Jennifer R Kramer, Lu-Yu Hwang, Ruosha Li, Eric L Brown, Eric A Engels
BACKGROUND: Hepatitis C virus (HCV) infection causes hepatocellular carcinoma (HCC) and subtypes of non-Hodgkin lymphoma (NHL). Associations with other cancers are not established. The authors systematically assessed associations between HCV infection and cancers in the US elderly population. METHODS: This was a registry-based case-control study using Surveillance, Epidemiology, and End Results (SEER)-Medicare data in US adults aged ≥66 years. Cases (n = 1,623,538) were patients who had first cancers identified in SEER registries (1993-2011)...
January 24, 2017: Cancer
https://www.readbyqxmd.com/read/28116137/merkel-cell-polyomavirus-and-cutaneous-merkel-cell-carcinoma
#13
EDITORIAL
Ettore Minutilli, Antonino Mulè
No abstract text is available yet for this article.
December 2016: Future Science OA
https://www.readbyqxmd.com/read/28105724/intraepidermal-proliferation-of-merkel-cells-within-a-seborrheic-keratosis-merkel-cell-carcinoma-in-situ-or-merkel-cell-hyperplasia
#14
Jeanne McFalls, Lauren Okon, Sarah Cannon, Jason B Lee
Intradepidermal proliferation of Merkel cells without any dermal component has been interpreted as either a hyperplastic process secondary to chronic ultraviolet radiation (UVR) or a neoplastic process, namely, Merkel cell carcinoma (MCC) in-situ. The recent criteria that have been proffered to diagnose MCC in-situ, unfortunately, are identical to those that have been applied to Merkel cell hyperplasia in the past, posing a diagnostic quandary when faced with an intraepidermal proliferation of Merkel cells...
January 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28104648/identification-of-merkel-cell-polyomavirus-from-a-patient-with-acute-myeloid-leukemia
#15
Y Song, P Gyarmati
Merkel cell polyomavirus (MCPyV) is an oncogenic virus associated with Merkel cell carcinoma, an aggressive form of skin cancer with a high (>30%) mortality rate. The virus has a high incidence in patients with immunosuppressed conditions, such as AIDS or leukemia, or following organ transplantation. Here, we report the complete genomic sequence of MCPyV identified from a blood sample from a patient with acute myeloid leukemia.
January 19, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28103445/factors-influencing-radiation-treatment-recommendations-in-early-stage-merkel-cell-carcinoma-a-survey-of-us-based-radiation-oncologists
#16
Yolanda D Tseng, Smith Apisarnthanarax, Jay J Liao, Shailender Bhatia, Paul T Nghiem, Upendra Parvathaneni
BACKGROUND: It is unclear which subgroups of Merkel cell carcinoma (MCC) patients benefit the most from radiation. We surveyed radiation oncologists (RO) that regularly see and treat MCC to understand how they approach the treatment of early-stage MCC. METHODS: A web-based survey was emailed to 63 ROs, who were identified through publications, guideline panel membership, and/or affiliation with institutions of high MCC volume. ROs provided treatment recommendations for two hypothetical case scenarios of early stage MCC...
March 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28099328/clinical-and-prognostic-significance-of-merkel-cell-polyomavirus-in-nonsmall-cell-lung-cancer
#17
Gun-Jik Kim, Jae-Ho Lee, Deok Heon Lee
Recently, an association between Merkel cell polyomavirus (MCPyV) and epidermal growth factor receptor (EGFR) mutations in nonsmall cell lung cancer (NSCLC) was reported. However, the underlying carcinogenic effects and the prognosis related to MCPyV are still unclear. The aim of this study was to clarify the incidence and prognosis related to MCPyV infections in NSCLC.Tissue samples from 167 NSCLC patients (92 with squamous cell carcinomas [SCCs] and 75 with adenocarcinomas) were analyzed for the presence of MCPyV and EGFR mutations...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28098567/multiple-enlarged-lymph-nodes-in-axilla-a-case-report-of-merkel-cell-carcinoma
#18
Muatasim Noorelahi, Rana Mahmood
: We present the case of a 59-year-old man with a growing mass in his left axillary area. A biopsy and immunostainings demonstrated neuroendocrine carcinoma, which is Merkel cell carcinoma (MCC). The disease is characterised by neurosecretory granules in tumor cells. MCC is a rare entity. The disease is predominantly seen in the inguinal region or the axilla and typically found incidentally. It presents clinically as multiple lymph nodes enlargement. Yet controversy exists regarding treatment modality of MCC...
January 16, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28098367/pd-1-checkpoint-blockade-is-an-emerging-treatment-for-merkel-cell-carcinoma
#19
N M Cassler, I Brownell
No abstract text is available yet for this article.
January 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28097368/incidence-of-and-risk-factors-for-skin-cancer-in-organ-transplant-recipients-in-the-united-states
#20
Giorgia L Garrett, Paul D Blanc, John Boscardin, Amanda Abramson Lloyd, Rehana L Ahmed, Tiffany Anthony, Kristin Bibee, Andrew Breithaupt, Jennifer Cannon, Amy Chen, Joyce Y Cheng, Zelma Chiesa-Fuxench, Oscar R Colegio, Clara Curiel-Lewandrowski, Christina A Del Guzzo, Max Disse, Margaret Dowd, Robert Eilers, Arisa Elena Ortiz, Caroline Morris, Spring K Golden, Michael S Graves, John R Griffin, R Samuel Hopkins, Conway C Huang, Gordon Hyeonjin Bae, Anokhi Jambusaria, Thomas A Jennings, Shang I Brian Jiang, Pritesh S Karia, Shilpi Khetarpal, Changhyun Kim, Goran Klintmalm, Kathryn Konicke, Shlomo A Koyfman, Charlene Lam, Peter Lee, Justin J Leitenberger, Tiffany Loh, Stefan Lowenstein, Reshmi Madankumar, Jacqueline F Moreau, Rajiv I Nijhawan, Shari Ochoa, Edit B Olasz, Elaine Otchere, Clark Otley, Jeremy Oulton, Parth H Patel, Vishal Anil Patel, Arpan V Prabhu, Melissa Pugliano-Mauro, Chrysalyne D Schmults, Sarah Schram, Allen F Shih, Thuzar Shin, Seaver Soon, Teresa Soriano, Divya Srivastava, Jennifer A Stein, Kara Sternhell-Blackwell, Stan Taylor, Allison Vidimos, Peggy Wu, Nicholas Zajdel, Daniel Zelac, Sarah T Arron
Importance: Skin cancer is the most common malignancy occurring after organ transplantation. Although previous research has reported an increased risk of skin cancer in solid organ transplant recipients (OTRs), no study has estimated the posttransplant population-based incidence in the United States. Objective: To determine the incidence and evaluate the risk factors for posttransplant skin cancer, including squamous cell carcinoma (SCC), melanoma (MM), and Merkel cell carcinoma (MCC) in a cohort of US OTRs receiving a primary organ transplant in 2003 or 2008...
January 11, 2017: JAMA Dermatology
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