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Merkel cell carcinoma

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https://www.readbyqxmd.com/read/28445980/the-pp4r1-sub-unit-of-protein-phosphatase-pp4-is-essential-for-inhibition-of-nf-%C3%AE%C2%BAb-by-merkel-polyomavirus-small-tumour-antigen
#1
Hussein Abdul-Sada, Marietta Müller, Rajni Mehta, Rachel Toth, J Simon C Arthur, Adrian Whitehouse, Andrew Macdonald
Merkel cell carcinoma (MCC) is a highly aggressive skin cancer with a high metastatic potential. The majority of MCC cases are caused by the Merkel cell polyomavirus (MCPyV), through expression of the virus-encoded tumour antigens. Whilst mechanisms attributing tumour antigen expression to transformation are being uncovered, little is known of the mechanisms by which MCPyV persists in the host. We previously identified the MCPyV small T antigen (tAg) as a novel inhibitor of nuclear factor kappa B (NF-kB) signalling and a modulator of the host anti-viral response...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28443305/talimogene-laherparepvec-for-regionally-advanced-merkel-cell-carcinoma-a-report-of-2-cases
#2
Jonathan T Blackmon, Ratika Dhawan, Toni M Viator, Nina L Terry, Robert M Conry
No abstract text is available yet for this article.
May 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28438774/avelumab-impresses-in-merkel-cell-carcinoma
#3
(no author information available yet)
The PD-L1 inhibitor avelumab-approved by the FDA in March for the treatment of Merkel cell carcinoma-demonstrated a high number of durable responses in an international, open-label, prospective phase II study. The results of the study, which supported the FDA's decision, were presented in April at the American Association for Cancer Research (AACR) Annual Meeting 2017.
April 24, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28423400/re-adjuvant-radiation-therapy-and-chemotherapy-in-merkel-cell-carcinoma-survival-analyses-of-6908-cases-from-the-national-cancer-data-base
#4
John A Vargo, Erica R Ghareeb, Goundappa K Balasubramani, Sushil Beriwal
No abstract text is available yet for this article.
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28414587/non-melanoma-skin-cancer-new-and-future-synthetic-drug-treatments
#5
Teresa Amaral, Claus Garbe
Non-melanoma skin cancers (NMSC) mainly comprise two different entities: basal cell carcinoma (BCC) and squamous cell carcinoma (SCC); beneath these two entities, Merkel cell carcinoma, adnexal tumors, dermatofibrosarcoma protuberans, angiosarcoma, and cutaneous lymphoma belong to NMSC. These rare skin tumors are not the topic of this review. BCC and SCC are the most common cancers diagnosed in humans. The preferred treatment is surgery, which in most cases is curative. Although a high recurrence rate is seen, these cancers rarely metastasize...
May 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28414163/droplet-digital-pcr-ddpcr-vs-quantitative-real-time-pcr-qpcr-approach-for-detection-and-quantification-of-merkel-cell-polyomavirus-mcpyv-dna-in-formalin-fixed-paraffin-embedded-ffpe-cutaneous-biopsies
#6
Rosaria Arvia, Mauro Sollai, Federica Pierucci, Carmelo Urso, Daniela Massi, Krystyna Zakrzewska
BACKGROUND: Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma and high viral load in the skin was proposed as a risk factor for the occurrence of this tumour. MCPyV DNA was detected, with lower frequency, in different skin cancers but since the viral load was usually low, the real prevalence of viral DNA could be underestimated. OBJECTIVE: To evaluate the performance of two assays (qPCR and ddPCR) for MCPyV detection and quantification in formalin fixed paraffin embedded (FFPE) tissue samples...
April 14, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28405827/mgmt-promoter-methylation-status-in-merkel-cell-carcinoma-in-vitro-versus-invivo
#7
Giuseppina Improta, Cathrin Ritter, Angela Pettinato, Valeria Vasta, David Schrama, Filippo Fraggetta, Jürgen C Becker
PURPOSE: Expression of O6-methylguanine-DNA methyltransferase (MGMT) in Merkel cell carcinoma (MCC) is very variable; thus, we tested whether this may be due to differential methylation of the MGMT gene promoter. METHODS: Quantitative analysis of MGMT mRNA and protein expression, as well as MGMT promoter methylation status, was performed in a series of tissue samples of MCC tumors, representing both primary and metastatic lesions, as well as in six MCC cell lines...
April 12, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28403527/basal-cell-carcinoma-cd56-and-cytokeratin-5-6-staining-patterns-in-the-differential-diagnosis-with-merkel-cell-carcinoma
#8
Gauri Panse, Jennifer M McNiff, Christine J Ko
BACKGROUND: Basal cell carcinoma (BCC) can resemble Merkel cell carcinoma (MCC) on histopathological examination and while CK20 is a useful marker in this differential, it is occasionally negative in MCC. CD56, a sensitive marker of neuroendocrine differentiation, is sometimes used to identify MCC, but has been reportedly variably positive in BCC as well. In contrast, CK5/6 consistently labels BCC but is not expressed in neuroendocrine tumors. METHODS: We evaluated twenty cases of BCC for the pattern of CD56 and cytokeratin 5/6 (CK5/6) staining, hypothesizing that these two stains could differentiate BCC from MCC in difficult cases...
April 12, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28403382/molecular-profiling-of-multiple-primary-merkel-cell-carcinoma-to-distinguish-genetically-distinct-tumors-from-clonally-related-metastases
#9
Kelly L Harms, Lorena Lazo de la Vega, Daniel H Hovelson, Samantha Rahrig, Andi K Cani, Chia-Jen Liu, Douglas R Fullen, Min Wang, Aleodor A Andea, Christopher K Bichakjian, Timothy M Johnson, Scott A Tomlins, Paul W Harms
Importance: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma. In rare cases, the development of an additional cutaneous MCC tumor is clinically consistent with a second primary MCC tumor rather than a cutaneous metastasis, which has important treatment and prognostic implications. Objective: To evaluate genetic relatedness in 4 cases with the clinical diagnosis of multiple primary MCCs. Design, Setting, and Participants: In this case series, 7 cases of clinically designated multiple primary MCC were identified; 4 cases met inclusion criteria for next-generation sequencing (NGS) analysis...
April 12, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28399340/what-s-new-in-eyelid-tumors
#10
Nora Silverman, Roman Shinder
Eyelid malignancies represent between 5% and 10% of all skin cancers. Basal cell carcinoma is the most common, followed by squamous cell carcinoma, sebaceous cell carcinoma, Merkel cell carcinoma, and melanoma. The gold standard treatment for periocular epithelial malignancies is surgical excision. Given the constraints of the anatomy and function of the eyelids, excision with negative margins and reconstruction can be challenging. In cases of significant tissue invasion or metastasis, complete tumor removal may not be possible...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28387053/morphological-and-immunocytochemical-features-of-merkel-cell-carcinoma-metastatic-to-the-pancreas-diagnosed-by-endoscopic-ultrasound-guided-fine-needle-aspiration
#11
Raffaella Lucci, Melania D' Anna, Antonio Marano, Elena Vigliar, Manuela Avellino, Vincenzo Napolitano, Giancarlo Troncone, Claudio Bellevicine
No abstract text is available yet for this article.
April 6, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28382918/merkel-cell-carcinoma-new-insights-into-pathogenesis
#12
Gianfranca Curzio, Francesca Paolini, Carlo Cota, Pietro Donati, Cinzia Di Mattia, Luciano Mariani, Emilia Migliano, Aldo Venuti
No abstract text is available yet for this article.
February 3, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28380668/spontaneous-lung-metastasis-formation-of-human-merkel-cell-carcinoma-cell-lines-transplanted-into-scid-mice
#13
Jill Knips, Manja Czech-Sioli, Michael Spohn, Max Heiland, Ingrid Moll, Adam Grundhoff, Udo Schumacher, Nicole Fischer
Merkel cell carcinoma (MCC) is an aggressive skin cancer entity that frequently leads to rapid death due to its high propensity to metastasize. The etiology of most MCC cases is linked to Merkel cell polyomavirus (MCPyV), a virus which is monoclonally integrated in up to 95% of tumors. While there are presently no animal models to study the role of authentic MCPyV infection on transformation, tumorigenesis or metastasis formation, xenograft mouse models employing engrafted MCC derived cell lines (MCCL) represent a promising approach to study certain aspects of MCC pathogenesis...
April 5, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28373005/avelumab-for-patients-with-previously-treated-metastatic-or-recurrent-non-small-cell-lung-cancer-javelin-solid-tumor-dose-expansion-cohort-of-a-multicentre-open-label-phase-1b-trial
#14
James L Gulley, Arun Rajan, David R Spigel, Nicholas Iannotti, Jason Chandler, Deborah J L Wong, Joseph Leach, W Jeff Edenfield, Ding Wang, Hans Juergen Grote, Anja von Heydebreck, Kevin Chin, Jean-Marie Cuillerot, Karen Kelly
BACKGROUND: Avelumab, a human Ig-G1 monoclonal antibody targeting PD-L1 and approved in the USA for the treatment of metastatic Merkel cell carcinoma, has shown antitumour activity and an acceptable safety profile in patients with advanced solid tumours in a dose-escalation phase 1a trial. In this dose-expansion cohort of that trial, we assess avelumab treatment in a cohort of patients with advanced, platinum-treated non-small-cell lung cancer (NSCLC). METHODS: In this dose-expansion cohort of a multicentre, open-label, phase 1 study, patients with progressive or platinum-resistant metastatic or recurrent NSCLC were enrolled at 58 cancer treatment centres and academic hospitals in the USA...
March 31, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28370725/impact-of-total-radiotherapy-dose-on-survival-for-head-and-neck-merkel-cell-carcinoma-after-resection
#15
Sagar A Patel, Muhammad M Qureshi, Kimberley S Mak, Debjani Sahni, Nicholas J Giacalone, Waleed Ezzat, Scharukh Jalisi, Minh Tam Truong
BACKGROUND: Head and neck Merkel cell carcinoma (MCC) is commonly treated with surgery and adjuvant radiotherapy (RT) for high-risk features. The optimal radiation dose is unknown. METHODS: One thousand six hundred twenty-five eligible patients with head and neck MCC were identified in the National Cancer Data Base (NCDB). Radiation dose was divided into 3 groups: 30 to <50 Gray (Gy), 50-55 Gy, and >55-70 Gy. Cox regression was used to compare overall survival (OS) between groups, accounting for age, sex, stage, surgery type, margin status, comorbidities, and use of chemotherapy...
March 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/28369761/erythema-ab-igne-new-technology-rebounding-upon-its-users
#16
REVIEW
Fernanda Salgado, Marc Z Handler, Robert A Schwartz
Erythema ab igne (EAI) is a persistent, chronic skin condition resulting from prolonged exposure to infrared radiation, experienced as heat. Once associated with traditional warming sources like wood burning stoves or open fires, modern, infrared exposure originates also from newer sources like laptops and heating pads and may be creating a rebound of EAI. The epidemiology may be different too, with younger patients than previously seen. Localized EAI over an area of pain in the abdomen or lower back can be a sign of an underlying disorder, including cancer...
March 30, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28367486/multiple-merkel-cell-carcinomas-late-metastasis-or-multiple-primary-tumors-a-molecular-study
#17
Madhulika Eluri, Ashley Feneran, Jeremy S Bordeaux, Beth Ruben, Stephen Ostrowski, Boris C Bastian, Kord Honda
No abstract text is available yet for this article.
March 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28359267/aberrant-expression-of-alk-and-ezh2-in-merkel-cell-carcinoma
#18
Tuukka Veija, Virve Koljonen, Tom Bohling, Mia Kero, Sakari Knuutila, Virinder Kaur Sarhadi
BACKGROUND: Distinct characteristic features categorize Merkel cell carcinoma (MCC) into two subgroups according to the Merkel cell polyomavirus infection. Many mutational studies on MCC have been carried out in recent years without identifying a prominent driver mutation. However, there is paucity reporting the expression of cancer genes at the RNA level in MCC tumors. In this study, we studied the RNA expression profiles of 26 MCC tumors, with a goal to identify prospective molecular targets that could improve the treatment strategies of MCC...
March 31, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28351503/natural-killer-cell-response-is-a-predictor-of-good-outcome-in-mcpyv-merkel-cell-carcinoma-a-case-series-of-23-patients
#19
Valerie Laniosz, Oluwakemi Onajin, Sindhuja Sominidi-Damodaran, Alexander Meves, Lawrence E Gibson, Christian L Baum
No abstract text is available yet for this article.
March 25, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28350693/prognostic-value-of-the-staging-system-for-eyelid-tumors-in-the-7th-edition-of-the-american-joint-committee-on-cancer-staging-manual
#20
Joshua Ford, Sudip Thakar, Bradley Thuro, Bita Esmaeli
PURPOSE: To determine the prognostic value of the staging criteria for eyelid tumors in the 7th edition of the American Joint Committee on Cancer (AJCC) staging manual and to determine, for each type of eyelid tumor, which AJCC T categories are associated with increased risk of nodal metastasis and thus potential usefulness of sentinel lymph node biopsy. METHODS: Systematic review and analysis of articles found by searching PubMed and Google Scholar using the search terms "AJCC," "eyelid," "carcinoma," and "melanoma...
March 27, 2017: Ophthalmic Plastic and Reconstructive Surgery
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