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https://www.readbyqxmd.com/read/29228074/a-review-of-the-current-therapies-challenges-and-future-directions-of-transcranial-focused-ultrasound-technology-advances-in-diagnosis-and-treatment
#1
Vibhor Krishna, Francesco Sammartino, Ali Rezai
Importance: Magnetic resonance imaging-guided focused ultrasound ablation has been approved for the treatment of refractory essential tremor and is being studied for other neurological indications, including dyskinesias and tremor in Parkinson disease, dystonia, neuropathic pain, obsessive-compulsive disorder, epilepsy, and brain tumors. Objective: To review the scientific foundations of FUS technology, existing neurological applications, and future advances. Evidence Review: PubMed was searched for the past 10 years using the terms "transcranial ultrasound," "focused ultrasound," and "neurological applications...
December 11, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29215661/-horner-s-syndrome-an-unusual-ophthalmological-presentation-of-hodgkin-lymphoma
#2
C Abascal Azanza, R Abarzuza Cortaire, P Plaza Ramos
Horner's Syndrome (HS) is a neurological syndrome characterised by the triad incomplete pupillary miosis, palpebral ptosis and facial anhidrosis, due to a lesion of the oculosympathetic pathway, formed of three neurons from the hipothalamus to the eye. Identifying its cause is a diagnostic challenge since in spite of its apparent lack of clinical importance, HS can be the first or only manifestation of a serious, or even potentially mortal disorder. We present the case of a 19-year-old male patient with a history of nonspecific ocular pains of two months evolution...
December 7, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/29213529/therapeutic-effect-of-transcranial-direct-current-stimulation-on-neuropsychological-symptoms-of-an-elderly-patient-a-case-report
#3
Aline Iannone, Joaquim Brasil-Neto, Antonio Pedro Mello Cruz, Corina Satler, Nasser Allam
Although growing evidence points to the potential therapeutic effects of transcranial Direct Current Stimulation (tDCS), there is still no consensus on the most appropriate protocol to be used in specific neurological and neuropsychological symptoms. This case report evaluated the neuromodulatory therapeutic effects of two 15-day courses of tDCS on an elderly female patient, aged 78 years with mild neurocognitive disorder, chronic pain and depression-related symptoms. Results indicated an overall significant improvement of cognitive and executive functions, as well as reduction in both depression and chronic pain symptoms...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29210178/acute-exposure-to-high-induction-electromagnetic-field-affects-activity-of-model-peripheral-sensory-neurons
#4
Jaroslav Prucha, Jan Krusek, Ivan Dittert, Viktor Sinica, Anna Kadkova, Viktorie Vlachova
Exposure to repetitive low-frequency electromagnetic field (LF-EMF) shows promise as a non-invasive approach to treat various sensory and neurological disorders. Despite considerable progress in the development of modern stimulation devices, there is a limited understanding of the mechanisms underlying their biological effects and potential targets at the cellular level. A significant impact of electromagnetic field on voltage-gated calcium channels and downstream signalling pathways has been convincingly demonstrated in many distinct cell types...
December 6, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29209545/difficult-to-treat-focal-stiff-person-syndrome-of-the-left-upper-extremity
#5
Nathan E Esplin, John W Stelzer, Timothy B Legare, Sayed K Ali
Background: Stiff person syndrome (SPS) is a rare neurologic disorder characterized by muscle rigidity. It is a disorder of reduced GABA activity leading to increased muscle tone and often painful spasms. It generally presents in the axial musculature but rarely can involve only one limb, typically a lower extremity. In rare cases it can be paraneoplastic which generally resolves on treatment of the underlying neoplasm. Case Report: A 46-year-old male with a history of Hodgkin's Lymphoma in remission presented with left upper extremity pain secondary to a diagnosis of Stiff Person Syndrome limited to his left upper extremity...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29208727/an-unusual-case-of-abdominal-pain-and-hyponatremia-in-a-16-year-old-girl-with-disordered-eating
#6
Grace Hunter, Rebecca Blankenburg, Jennifer Andrews, Terrell Stevenson
A previously healthy 16-year-old girl presented to the emergency department with 1 week of severe, diffuse abdominal pain and constipation, as well as several episodes of nonbloody, nonbilious emesis. Her symptoms began several days after she decreased her caloric intake in an attempt to lose weight. She had been drinking 48 to 60 oz of water per day for several days before admission in an attempt to ameliorate her constipation. She also admits to drinking alcohol the night before her pain began. She had visited several other emergency departments before her presentation to our hospital, and she had been sent home on a bowel regimen without amelioration of her symptoms...
December 5, 2017: Pediatrics
https://www.readbyqxmd.com/read/29203121/using-a-memory-systems-lens-to-view-the-effects-of-estrogens-on-cognition-implications-for-human-health
#7
Donna L Korol, Wei Wang
Understanding the organizing and activating effects of gonadal steroids on adult physiology can guide insight into sex differences in and hormonal influences on health and disease, ranging from diabetes and other metabolic disorders, emotion and stress regulation, substance abuse, pain perception, immune function and inflammation, cognitive function and dysfunction accompanying neurological disorders. Because the brain is highly sensitive to many forms of estrogens, it is not surprising that many adult behaviors, including cognitive function, are modulated by estrogens...
December 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29194677/chronic-inflammatory-demyelinating-polyneuropathy-and-malignancy-a-systematic-review
#8
REVIEW
Yusuf A Rajabally, Shahram Attarian
A systematic review of the literature was performed on the association of chronic inflammatory demyelinating polyneuropathy (CIDP) with malignancy. Hematologic disorders are the most common association, particulalry non-Hodgkin's lymphoma. CIDP frequently precedes the malignancy diagnosis, and there is a favorable CIDP response to treatment more than 70% of the time. Melanoma is the second most common association, and may be accompanied by antiganglioside antibodies; the CIDP shows a good response to immunotherapy...
December 1, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29190962/wu-tou-decoction-attenuates-neuropathic-pain-via-suppressing-spinal-astrocytic-il-1r1-traf6-jnk-signaling
#9
Chao Wang, Xiangying Kong, Chunyan Zhu, Chunfang Liu, Danni Sun, Qionghong Xu, Zhiyun Mao, Qingxia Qin, Hongchang Su, Danqiao Wang, Xiaoliang Zhao, Na Lin
Neuropathic pain (NP) caused by nerve injuries continues to be an intractable challenge due to inadequate therapeutic strategies. Recent study demonstrated glia-induced neuro-inflammation in the spinal cord, especially the activation of astrocytes, plays an essential role in the development of NP, which opens new avenues for NP treatment. In this study, we explored the anti-hyperalgesia properties of Wu-tou decoction (WTD) and showed that WTD potently attenuates mechanical allodynia and heat hyperalgesia in lumbar 5 (L5) spinal nerve ligation (SNL)-induced NP without noticeable side effect or affecting basal pain perception of mice...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29189887/eosinophilic-granulomatosis-with-polyangiitis-without-respiratory-symptoms-or-asthma-in-an-adolescent-case-report-and-literature-review
#10
REVIEW
Gülçin Otar Yener, Zahide Ekici Tekin, Neşe Çallı Demirkan, Selçuk Yüksel
Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg-Strauss syndrome, is a systemic necrotizing vasculitis of the small and medium vessels. It is primarily associated with respiratory conditions such as asthma and sinusitis as well as eosinophilia, neuropathy, pulmonary infiltrates, and vasculitis. EGPA is extremely rare in the pediatric age group, and respiratory system disorders are usually predominant in EGPA patients. A 14-year-old boy presented with rash and severe extremity pain...
November 30, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29171498/-temporomandibular-disorder-as-the-most-prevalent-cause-of-facial-pain-current-evidence
#11
N V Latysheva, E G Filatova, V V Osipova
Orofacial pain is a comprehensive and multi-faceted syndrome. After dental causes have been excluded, neurologists are challenged to diagnose the cause of pain. The paper gives a detailed review of one of the most common causes of facial pain - temporomandibular disorder (TMD). Current DC/TMD diagnostic criteria, patient examination protocols and a new perspective on TMD pathophysiology based on the recent neurological studies are presented. The article also discusses modern approaches to TMD management.
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29152209/case-control-study-hyperbaric-oxygen-treatment-of-mild-traumatic-brain-injury-persistent-post-concussion-syndrome-and-post-traumatic-stress-disorder
#12
Paul G Harch, Susan R Andrews, Edward F Fogarty, Juliette Lucarini, Keith W Van Meter
Mild traumatic brain injury (TBI) persistent post-concussion syndrome (PPCS) and post-traumatic stress disorder (PTSD) are epidemic in United States Iraq and Afghanistan War veterans. Treatment of the combined diagnoses is limited. The aim of this study is to assess safety, feasibility, and effectiveness of hyperbaric oxygen treatments (HBOT) for mild TBI PPCS and PTSD. Thirty military subjects aged 18-65 with PPCS with or without PTSD and from one or more blast-induced mild-moderate traumatic brain injuries that were a minimum of 1 year old and occurred after 9/11/2001 were studied...
July 2017: Medical Gas Research
https://www.readbyqxmd.com/read/29152001/total-knee-arthroplasty-in-patients-with-parkinson-s-disease-a-critical-analysis-of-available-evidence
#13
REVIEW
Munis Ashraf, Sruthi Priyavadhana, Senthil Nathan Sambandam, Varatharaj Mounasamy, Om Prakash Sharma
Background: In this era of modern medicine, there is an increase in life expectancy and thereby an ageing population. Among this group one of the most common neurological disorder is Parkinson disease and one of the most common operation done in elderly population is a total joint arthroplasty. But total joint arthroplasty in Parkinson disease is a relatively uncommon entity. There is sparse literature available with regards to total knee arthroplasty (TKA) in Parkinson disease. This review focusses on the necessity, complications and previous experiences on TKA in PD based on the literature available...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29145497/rare-genetic-variants-in-the-endocannabinoid-system-genes-cnr1-and-dagla-are-associated-with-neurological-phenotypes-in-humans
#14
Douglas R Smith, Christine M Stanley, Theodore Foss, Richard G Boles, Kevin McKernan
Rare genetic variants in the core endocannabinoid system genes CNR1, CNR2, DAGLA, MGLL and FAAH were identified in molecular testing data from 6,032 patients with a broad spectrum of neurological disorders. The variants were evaluated for association with phenotypes similar to those observed in the orthologous gene knockouts in mice. Heterozygous rare coding variants in CNR1, which encodes the type 1 cannabinoid receptor (CB1), were found to be significantly associated with pain sensitivity (especially migraine), sleep and memory disorders-alone or in combination with anxiety-compared to a set of controls without such CNR1 variants...
2017: PloS One
https://www.readbyqxmd.com/read/29145179/phantom-sensations-supernumerary-phantom-limbs-and-apotemnophilia-three-body-representation-disorders
#15
Laurent Tatu, Julien Bogousslavsky
Body representation disorders continue to be mysterious and involve the anatomical substrate that underlies the mental representation of the body. These disorders sit on the boundaries of neurological and psychiatric diseases. We present the main characteristics of 3 examples of body representation disorders: phantom sensations, supernumerary phantom limb, and apotemnophilia. The dysfunction of anatomical circuits that regulate body representation can sometimes have paradoxical features. In the case of phantom sensations, the patient feels the painful subjective sensation of the existence of the lost part of the body after amputation, surgery or trauma...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29135610/meralgia-paresthetica-after-spine-surgery-on-the-jackson-table
#16
Nitin Agarwal, Jaydev B Mistry, Preeya V Khandge, David R Hansberry, Ira M Goldstein
Meralgia paresthetica is a non-life-threatening neurological disorder characterized by numbness, tingling, and burning pain over the anterolateral thigh due to impingement of the lateral femoral cutaneous nerve. This disorder has been seen in patients with diabetes mellitus and obesity, but has also been observed in patients after procedures such as posterior spine surgery, iliac crest bone grafts, lumbar disk surgery, hernia repair, appendectomies, and pelvic osteotomies that ultimately lead to compression or damage to the lateral femoral cutaneous nerve...
November 10, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29132273/neuropsychiatric-factors-linked-to-adherence-and-short-term-outcome-in-a-u-s-functional-neurological-disorders-clinic-a-retrospective-cohort-study
#17
Sean P Glass, Nassim Matin, Benjamin Williams, Julie Mello, Christopher D Stephen, Sigrid S Young, Janet Callahan, W Curt LaFrance, David L Perez
Despite advancements in the assessment and management of functional neurological disorder (FND), the feasibility of implementing a new standard of care remains unclear. Chart reviews were performed for 100 patients with motor FND to investigate factors related to treatment adherence and clinical improvement over an average follow-up of 7 months. Of 81 patients who returned for follow-up, a history of chronic pain disorder inversely correlated with improvement. Of the 50 individuals newly referred for treatment, adherence correlated with improvement, while having abnormal neuroimaging inversely correlated with improvement...
November 14, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29131336/molecular-function-of-%C3%AE-7-nicotinic-receptors-as-drug-targets
#18
Cecilia Bouzat, Matías Lasala, Beatriz Elizabeth Nielsen, Jeremías Corradi, María Del Carmen Esandi
Nicotinic acetylcholine receptors (nAChR) are pentameric ligand-gated ion channels involved in many physiological and pathological processes. In vertebrates, there are seventeen different nAChR subunits that combine to yield a variety of receptors with different pharmacology, function, and localization. The homomeric α7 receptor is one of the most abundant nAChRs in the nervous system and it is also present in non-neuronal cells. It plays important roles in cognition, memory, pain, neuroprotection, and inflammation...
November 13, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29125908/transgender-medicare-beneficiaries-and-chronic-conditions-exploring-fee-for-service-claims-data
#19
Christina N Dragon, Paul Guerino, Erin Ewald, Alison M Laffan
PURPOSE: Data on the health and well-being of the transgender population are limited. However, using claims data we can identify transgender Medicare beneficiaries (TMBs) with high confidence. We seek to describe the TMB population and provide comparisons of chronic disease burden between TMBs and cisgender Medicare beneficiaries (CMBs), thus laying a foundation for national level TMB health disparity research. METHODS: Using a previously validated claims algorithm based on ICD-9-CM codes relating to transsexualism and gender identity disorder, we identified a cohort of TMBs using Medicare Fee-for-Service (FFS) claims data...
November 10, 2017: LGBT Health
https://www.readbyqxmd.com/read/29125291/identification-of-a-new-pyrazolo-1-5-a-quinazoline-ligand-highly-affine-to-%C3%AE-aminobutyric-type-a-gabaa-receptor-subtype-with-anxiolytic-like-and-antihyperalgesic-activity
#20
Gabriella Guerrini, Giovanna Ciciani, Letizia Crocetti, Simona Daniele, Carla Ghelardini, Maria Paola Giovannoni, Antonella Iacovone, Lorenzo Di Cesare Mannelli, Claudia Martini, Claudia Vergelli
Compounds that can act on GABAA receptor subtype in a selective manner, without the side effects of classical benzodiazepine ligands, represent promising therapeutic tools in neurological disorder as well as for relief of pain or in comorbidity of anxiety states and depression. Continuing our research on GABAA receptor subtype ligands, here is reported the synthesis of a series of pyrazolo[1,5-a]quinazoline 3- and/or 8-substituted as 5-deaza analogues of previous reported pyrazolo[5,1-c][1,2,4]benzotriazine, already identified as selective GABAA receptor subtype ligands endowed with anxiolytic-like and antihyperalgesic action or enhancer cognition...
November 22, 2017: Journal of Medicinal Chemistry
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