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Neurological pain disorder

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https://www.readbyqxmd.com/read/29911617/cerebrospinal-fluid-levels-of-substance-p-sp-n-terminal-fragment-sp1-7-in-patients-with-neuropathic-pain
#1
A Jonsson, A-L Lind, M Hallberg, F Nyberg, T Gordh
Aims Neuropathic pain is a complex and painful condition, which is difficult to treat and causes a lot of suffering. The substance P (SP) system is well known to be involved in nociceptive signaling and it has previously been shown that the cerebrospinal fluid (CSF) level of SP is decreased in neuropathic pain. In this study we analyzed CSF from chronic neuropathic pain patients for the levels of SP1-7, an N-terminal fragment of SP with the ability to alleviate thermal as well as mechanical hypersensitivity in different animal models of chronic neuropathic pain, e...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29898036/role-of-non-coding-rnas-in-non-aging-related-neurological-disorders
#2
A S Vieira, D B Dogini, I Lopes-Cendes
Protein coding sequences represent only 2% of the human genome. Recent advances have demonstrated that a significant portion of the genome is actively transcribed as non-coding RNA molecules. These non-coding RNAs are emerging as key players in the regulation of biological processes, and act as "fine-tuners" of gene expression. Neurological disorders are caused by a wide range of genetic mutations, epigenetic and environmental factors, and the exact pathophysiology of many of these conditions is still unknown...
June 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29887336/an-improved-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-method-for-simultaneous-quantitation-of-cytochrome-p450-metabolites-of-arachidonic-acid-in-human-plasma
#3
Yan Zhang, Meng-Yao Wang, Qi-Yuan Huang, Min-Zhen Zhu, Jing Ren, Xiong Cao, Wen-Chao Xiong, Xiao-Dan Xiao, Xin-Hong Zhu
This study aims to develop a straightforward, sensitive UHPLC-MS/MS method to quantify 15 eicosanoids derived from arachidonic acid in human plasma. Tert-Butyl methyl ether was used on the liquid-liquid extraction method and significantly reduced the expense and time. The method showed excellent linearity for all analytes, with regression coefficients higher than 0.99 over a wide range of concentrations from 0.01 ng mL-1 to 100 ng mL-1 . The recovery rates were over 65.00%, and the matrix effects ranged from 8...
June 4, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29882776/the-role-of-magnesium-in-neurological-disorders
#4
REVIEW
Anna E Kirkland, Gabrielle L Sarlo, Kathleen F Holton
Magnesium is well known for its diverse actions within the human body. From a neurological standpoint, magnesium plays an essential role in nerve transmission and neuromuscular conduction. It also functions in a protective role against excessive excitation that can lead to neuronal cell death (excitotoxicity), and has been implicated in multiple neurological disorders. Due to these important functions within the nervous system, magnesium is a mineral of intense interest for the potential prevention and treatment of neurological disorders...
June 6, 2018: Nutrients
https://www.readbyqxmd.com/read/29876262/-motoring-in-idle-the-default-mode-and-somatomotor-networks-are-overactive-in-children-and-adolescents-with-functional-neurological-symptoms
#5
Kasia Kozlowska, Chris J Spooner, Donna M Palmer, Anthony Harris, Mayuresh S Korgaonkar, Stephen Scher, Leanne M Williams
Objective: Children and adolescents with functional neurological symptom disorder (FND) present with diverse neurological symptoms not explained by a disease process. Functional neurological symptoms have been conceptualized as somatoform dissociation, a disruption of the brain's intrinsic organization and reversion to a more primitive level of function. We used EEG to investigate neural function and functional brain organization in children/adolescents with FND. Method: EEG was recorded in the resting eyes-open condition in 57 patients (aged 8...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29875920/-hemorrhagic-rupture-of-a-giant-arteriovenous-malformation-in-a-young-man-in-ouagadougou
#6
Anselme Alfred Dabilgou, Julie Marie Adeline Kyelem
Vascular arteriovenous malformations (VAM) are aggressive vascular diseases associated with increased haemorrhagic risk in terms of morbidity and mortality. Vascular arteriovenous malformations are usually sporadic. The main symptom of VAM is hemorrhage, in 50% of cases. We here report the case of a 28 year old patient, hospitalized with right sided motor deficit of acute onset associated with consciousness disorder in the Department of Neurology at the Yalgado Ouédraogo University Hospital Center. The patient had a history of chronic headaches treated with self-medication and of right Bravais-Jacksonian seizures...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29872919/-parkinson-s-disease-alzheimer-s-disease-and-oncological-diseases-in-residential-geriatric-care-pain-frequency-and-selected-healthcare-features-in-comparison
#7
REVIEW
P Kutschar, K Lex, J Osterbrink, S Lorenzl
BACKGROUND: Adequate pain management and palliative care structures are of significant importance in residential nursing homes. Whilst professional pain treatment and palliative care measures are frequently implemented for residents with oncological diseases, this is often not the case for residents with neurological disorders. Such a potential undertreatment is even more challenging when the means of interaction and communication with affected persons are aggravated by impairments in cognitive function...
June 5, 2018: Der Schmerz
https://www.readbyqxmd.com/read/29872383/from-the-bottom-up-chemotherapy-and-gut-brain-axis-dysregulation
#8
REVIEW
Juliana E Bajic, Ian N Johnston, Gordon S Howarth, Mark R Hutchinson
The central nervous system and gastrointestinal tract form the primary targets of chemotherapy-induced toxicities. Symptoms associated with damage to these regions have been clinically termed chemotherapy-induced cognitive impairment and mucositis. Whilst extensive literature outlines the complex etiology of each pathology, to date neither chemotherapy-induced side-effect has considered the potential impact of one on the pathogenesis of the other disorder. This is surprising considering the close bidirectional relationship shared between each organ; the gut-brain axis...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29867723/what-is-the-role-of-the-placebo-effect-for-pain-relief-in-neurorehabilitation-clinical-implications-from-the-italian-consensus-conference-on-pain-in-neurorehabilitation
#9
REVIEW
Gianluca Castelnuovo, Emanuele Maria Giusti, Gian Mauro Manzoni, Donatella Saviola, Samantha Gabrielli, Marco Lacerenza, Giada Pietrabissa, Roberto Cattivelli, Chiara Anna Maria Spatola, Alessandro Rossi, Giorgia Varallo, Margherita Novelli, Valentina Villa, Francesca Luzzati, Andrea Cottini, Carlo Lai, Eleonora Volpato, Cesare Cavalera, Francesco Pagnini, Valentina Tesio, Lorys Castelli, Mario Tavola, Riccardo Torta, Marco Arreghini, Loredana Zanini, Amelia Brunani, Ionathan Seitanidis, Giuseppe Ventura, Paolo Capodaglio, Guido Edoardo D'Aniello, Federica Scarpina, Andrea Brioschi, Matteo Bigoni, Lorenzo Priano, Alessandro Mauro, Giuseppe Riva, Daniele Di Lernia, Claudia Repetto, Camillo Regalia, Enrico Molinari, Paolo Notaro, Stefano Paolucci, Giorgio Sandrini, Susan Simpson, Brenda Kay Wiederhold, Santino Gaudio, Jeffrey B Jackson, Stefano Tamburin, Fabrizio Benedetti
Background: It is increasingly acknowledged that the outcomes of medical treatments are influenced by the context of the clinical encounter through the mechanisms of the placebo effect. The phenomenon of placebo analgesia might be exploited to maximize the efficacy of neurorehabilitation treatments. Since its intensity varies across neurological disorders, the Italian Consensus Conference on Pain in Neurorehabilitation (ICCP) summarized the studies on this field to provide guidance on its use...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29866668/case-of-primary-sjogren-s-syndrome-preceded-by-dystonia
#10
Kerime Ararat, Idanis Berrios, Anas Hannoun, Carolina Ionete
There are only six cases in literature that describe development of dystonia with Sjogren's syndrome (SS). We describe a case of a 43-year-old woman who presented with symptoms including movement disorder, sensory neurogenic bladder, sensory loss and neuropathic pain, migraine like headaches, musculoskeletal pain, Raynaud's phenomenon and dysautonomia. Symptoms started in 2000, with weakness that progressed to dystonia in 2003. Diagnostic work-up was inconclusive with negative inflammatory serologies, cerebrospinal fluid and MRI for many years...
June 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29865933/complex-regional-pain-syndrome-type-1-in-the-medico-legal-setting-high-rates-of-somatoform-disorders-opiate-use-and-diagnostic-uncertainty
#11
Christopher Bass, Gregory Yates
Objective The aim of this study was to review demographic and clinical characteristics of patients with complex regional pain syndrome type 1 (CRPS) seen in a UK medico-legal setting - particularly the relationship between CRPS and somatoform disorders. Methods Fifty consecutive cases of CRPS (interviewed 2005-2016) undergoing psychiatric assessment were reviewed. A systematic assessment of mental states was conducted via interview and examination of medical/psychiatric records. Thirty patients also completed the Brief Illness Perception Questionnaire (BIPQ)...
January 1, 2018: Medicine, Science, and the Law
https://www.readbyqxmd.com/read/29860667/fatigue-not-self-rated-motor-symptom-severity-affects-quality-of-life-in-functional-motor-disorders
#12
J M Gelauff, E M Kingma, J S Kalkman, R Bezemer, B G M van Engelen, J Stone, M A J Tijssen, J G M Rosmalen
While fatigue is found to be an impairing symptom in functional motor disorders (FMD) in clinical practice, scientific evidence is lacking. We investigated fatigue severity and subtypes in FMD compared to organic neurological disease. Furthermore, the role of fatigue within FMD and its impact on quality of life and self-rated health were investigated. Data from 181 patients participating in the self-help on the internet for functional motor disorders, randomised Trial were included. Data from 217 neurological controls with neuromuscular disorders (NMD) originated from a historical cohort...
June 2, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29804893/using-promis-pain-interference-items-to-improve-quality-measurement-in-inpatient-rehabilitation-facilities
#13
Benjamin D Schalet, Michael A Kallen, Allen W Heinemann, Anne Deutsch, Karon F Cook, Linda Foster, David Cella
OBJECTIVE: To evaluate the Patient-Reported Outcomes Measurement Information System (PROMIS) pain interference items for use in a quality measure and to compare the resulting quality score, along with internal reliability and validity, to a similar item set in the Minimum Data Set Version 3.0 (MDS). DESIGN: Cross-sectional, observational study. SETTING: One freestanding inpatient rehabilitation facility (IRF) and one large hospital-based IRF...
May 24, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29802812/comorbid-fibromyalgia-a-qualitative-review-of-prevalence-and-importance
#14
REVIEW
Mary-Ann Fitzcharles, Serge Perrot, Winfried Häuser
BACKGROUND AND OBJECTIVE: Fibromyalgia (FM) may be an unrecognized cause of suffering for persons with an array of medical conditions. This is especially true for illness that is characterized by pain of any nature. Once believed to be a unique diagnosis, FM is recently reported to occur concomitantly with various rheumatic diseases, and importantly adversely impacts global health status. However there is increasing report of FM associated with other diseases that are not defined by chronic pain...
May 26, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29799282/analysis-of-predictors-of-opioid-free-analgesia-for-management-of-acute-post-surgical-pain-in-the-united-states
#15
Richard D Urman, Elaine A Böing, Victor Khangulov, Randi Fain, Brian H Nathanson, George J Wan, Belinda Lovelace, An T Pham, Jessica Cirillo
OBJECTIVES: Utilization of opioid-free analgesia (OFA) for post-surgical pain is a growing trend to counter the risks of opioid abuse and opioid-related adverse drug events (ORADEs). However, utilization patterns of OFA have not been examined. In this study, we investigated the utilization patterns and predictors of OFA in a surgical population in the United States. METHODS: Analysis of the Cerner Health Facts® database (1/2011 to 12/2015) was conducted to describe hospital and patient characteristics associated with OFA...
May 25, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29794310/superior-outcomes-following-cervical-fusion-vs-multimodal-rehabilitation-in-a-subgroup-of-randomized-whiplash-associated-disorders-wad-patients-indicating-somatic-pain-origin-comparison-of-outcome-assessments-made-by-four-examiners-from-different-disciplines
#16
Elisabeth Svensson, Bo Nyström, Ian Goldie, Nils Inge Landrø, Åke Sidén, Peer Staff, Birgitta Schillberg, Adam Taube
BACKGROUND AND AIMS: Whiplash-Associated Disorders (WAD) are characterized by great variability in long-term symptoms. Patients with central neck and movement-induced stabbing pain participated in a randomized study comparing cervical fusion and multimodal rehabilitation. As reported in our previous paper, more patients treated by cervical fusion than by rehabilitation experienced pain relief. Although patient reported outcome measures are a core component of outcome evaluation, independent examiner has been recommended...
April 25, 2018: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29792388/cerebral-ischaemia-reperfusion-injury-could-be-managed-by-using-tramadol
#17
Ibrahim Akkurt, Cansel Cetin, Ahmet Melih Erdogan, Gungor Cagdas Dincel, Aslı Fahriye Ceylan, Ucler Kisa, Jonathan Oppong, Adem Akkurt, Mustafa Ogden, Bulent Bakar
OBJECTIVES: No valid treatment modality that will repair stroke damage and provide neurological recovery has yet been identified in literature. Studies demonstrated that adequate quality of life could be provided if post-stroke pain could be treated sufficiently and timely. Besides its pain relief effects, tramadol has oedema-reducing and anti-inflammatory properties. With these in mind, this study investigated the influence of tramadol in acute and/or chronic ischaemia/reperfusion (I/R) injury...
May 24, 2018: Neurological Research
https://www.readbyqxmd.com/read/29787878/gamma-knife-radiosurgery-of-the-superior-laryngeal-neuralgia-a-report-of-three-cases
#18
Peng Fu, Nan-Xiang Xiong, Ahmed Abdelmaksoud, Yi-Zhi Huang, Guo-Bin Song, Hong-Yang Zhao
BACKGROUND: Superior laryngeal neuralgia (SLN) is a relatively rare disorder that is characterized by neck pain. There are only a few reported cases and treatment options for SLN to date. OBJECTIVE: In this study, we reported 3 patients with SLN who were treated with gamma knife radiosurgery (GKRS) at the time of diagnosis. METHODS: For all 3 patients, GKRS was administered using a 4-mm collimator to deliver a single shot of 80 Gy of radiation (the 100% isodose line)...
May 19, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29781731/neuropsychologists-as-primary-care-providers-of-cognitive-health-a-novel-comprehensive-cognitive-wellness-service-delivery-model
#19
Patricia A Pimental, John B O'Hara, Jessica L Jandak
By virtue of their extensive knowledge base and specialized training in brain-behavior relationships, neuropsychologists are especially poised to execute a unique broad-based approach to overall cognitive wellness and should be viewed as primary care providers of cognitive health. This article will describe a novel comprehensive cognitive wellness service delivery model including cognitive health, anti-aging, lifelong wellness, and longevity-oriented practices. These practice areas include brain-based cognitive wellness, emotional and spiritually centric exploration, and related multimodality health interventions...
July 2018: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29780794/pediatric-scurvy-when-contemporary-eating-habits-bring-back-the-past
#20
Alice Brambilla, Cristina Pizza, Donatella Lasagni, Lucia Lachina, Massimo Resti, Sandra Trapani
Vitamin C deficiency is anecdotal in developed countries, mainly associated with underling clinical morbidities as autism or neurological impairment. Chronic insufficient dietary supply is responsible for vascular fragility and impaired bone formation, resulting in gingival bleeding, petechial lesions, articular and bone pain or limb swelling. Children may present anorexia, irritability, failure to thrive, limping or refusal to walk. Accordingly, pediatric scurvy is frequently misdiagnosed with osteomyelitis, septic arthritis, bone and soft tissue tumor, leukemia, bleeding disorders, and rheumatologic conditions...
2018: Frontiers in Pediatrics
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