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Guidelines Adherence Antibiotic

Su Youn Kim, Falk R Ochsendorf
The fixed-dose combination adapalene 0.1%/benzoylperoxide 2.5% (A/BPO) was introduced as an acne vulgaris therapeutic in 2007. It combines anti-inflammatory, keratolytic, comedolytic, and antibacterial properties. Thus, it addresses several pathophysiological factors involved in the pathophysiology of acne. This review highlights the rationale for the use of this fixed-dose combination product, its therapeutic efficacy including effects on adherence and quality of life, its use for different forms of acne, and the side-effect profile...
2016: Therapeutics and Clinical Risk Management
Bashir Mohamed Elmahi Yousif, Siripen Supakankunti
BACKGROUND: The appropriate use of medicines is essential for the provision of quality health services, patient safety, and the rational use of health resources. In Sudan, general practitioners (GPs) provide 80 % of insured patients' health services. Pharmaceutical service costs have been increasing since 2010. OBJECTIVES: We aimed to use the World Health Organization (WHO) and International Network for the Rational Use of Drugs prescribing indicators to assess prescription quality among GPs in different types of primary healthcare centers (PHCCs) within the National Health Insurance Fund (NHIF) in Gezira State, Sudan...
September 2016: Drugs—Real World Outcomes
S Miehlke, R Loibl, S Meszaros, J Labenz
Purpose: The acceptance and realization of clinical guidelines in daily routine practice is unknown. The aim of this study was to evaluate the behaviour of private gastroenterologists in Germany with respect to the diagnostic and therapeutic management of H. pylori infection in times of increasing antibiotic resistance. Methods: Between 12/2014 and 02/2015 a standardized questionnaire with 19 multiple choice questions were sent to 1507 private gastroenterologists in Germany. The data were electronically captured and analyzed using SurveyMonkey...
October 2016: Zeitschrift Für Gastroenterologie
Tamara D Simon, Matthew P Kronman, Kathryn B Whitlock, Nancy Gove, Samuel R Browd, Richard Holubkov, John R W Kestle, Abhaya V Kulkarni, Marcie Langley, David D Limbrick, Thomas G Luerssen, Jerry Oakes, Jay Riva-Cambrin, Curtis Rozzelle, Chevis Shannon, Mandeep Tamber, John C Wellons, William E Whitehead, Nicole Mayer-Hamblett
OBJECTIVES: To describe the variation in approaches to surgical and antibiotic treatment for first cerebrospinal fluid (CSF) shunt infection and adherence to Infectious Diseases Society of America (IDSA) guidelines. STUDY DESIGN: We conducted a prospective cohort study of children undergoing treatment for first CSF infection at 7 Hydrocephalus Clinical Research Network hospitals from April 2008 through December 2012. Univariate analyses were performed to describe the study population...
September 27, 2016: Journal of Pediatrics
Mehul Agrawal, Pramod Kumar Sharma, S P Dhaneria
BACKGROUND: Antimicrobial prophylaxis should be used in circumstances where efficacy has been demonstrated and benefits outweigh the risk. Each hospital must have an antibiotic policy that is implementable and fully adhered to. METHODS: A prospective observational study was conducted in 209 patients, admitted to swards of various surgical departments including surgery, obstetrics & gynaecology (O&G), otorhinolaryngology (ENT) and orthopaedics. Relevant antimicrobial use data of each patient was collected in a customized Case Record Form (CRF) from day one until patient was discharged...
September 26, 2016: Reviews on Recent Clinical Trials
Alike W van der Velden, Monique Roukens, Ewoudt van de Garde, Marco Lourens, Stephanie Natsch
QUALITY PROBLEM: Inappropriate antibiotic use drives development of antimicrobial resistance. Worldwide, guideline adherence for antibiotic treatment of infectious disease is far from optimal. Insight in prescribing quality is pivotal for healthcare professionals and policy makers to intervene appropriately. INITIAL ASSESSMENTS: European countries uniformly monitor antibiotic use, which is reported yearly by the European Centre for Disease Prevention and Control...
September 24, 2016: International Journal for Quality in Health Care
Kirstie Graham, Chomba Sinyangwe, Sarala Nicholas, Rebecca King, Samuel Mukupa, Karin Källander, Helen Counihan, Mark Montague, James Tibenderana, Prudence Hamade
BACKGROUND: Antibiotic resistance is an issue of growing global concern. One key strategy to minimise further development of resistance is the rational use of antibiotics, by providers and patients alike. Through integrated community case management (iCCM), children diagnosed with suspected pneumonia are treated with antibiotics; one component of an essential package to reduce child mortality and increase access to health care for remote populations. Through the use of clinical algorithms, supportive supervision and training, iCCM also offers the opportunity to improve the rational use of antibiotics and limit the spread of resistance in resource-poor contexts...
2016: BMC Public Health
Hirminder Ubhi, Mitul Patel, Lisa Ludwig
AIM: Aims of the study included evaluation of outpatient antibiotic prescribing practices relating to good Antimicrobial Stewardship1 focusing on documentation of indication and duration. METHOD: Prescriptions dispensed at the Outpatient Pharmacy over a 6 week were evaluated. Data collected include patient's hospital identification in full, the antibiotic prescribed, duration of treatment, indication (in a specifically allocated area on the prescription) and route of administration, prescriber speciality and grade...
September 2016: Archives of Disease in Childhood
Sanna Zaffar, Penny Fletcher
AIM: To assess compliance with paediatric empiric anti-infective guidelines and anti-infective drug dose table for children. METHOD: Data collection was carried out on the paediatric wards. EXCLUSIONS: ▸ Bone marrow transplant patients (BMT).▸ Patients not on empirical anti-infective treatmentData were collected prospectively between January and 30 February 2015. A data collection form was completed and data analysed using Excel. STANDARDS: (1) 90% adherence to the paediatric guidelines for empirical anti-infectives treatment(2) 90% prescriptions have the indication recorded in either the drug charts or notes(3) 90% prescriptions have duration recorded of treatment/review date on drug chart or medical notes(4) 95% initial doses should adhere to the anti-infective drug dose table for children RESULTS: Data were collected from 50 patients; eight were subsequently excluded as they were not on empirical treatment or were prescribed antibiotics started prior to admission giving a final sample for analysis of 42...
September 2016: Archives of Disease in Childhood
Gabis Chana, Michelle Tabberner, Wendy Nixon, Sue Frost, Leslie Barrett, Maya Desai, Lucy Paskin
AIM: With pressures on junior doctors' availability in the NHS, non-medical prescribing is topical. Independent Nurse Prescribers (INPs) can prescribe any licensed medicine for any medical condition within their level of competence.1 An audit was undertaken of the four INPs employed by the Respiratory Department evaluating current prescribing practices. METHOD: The requirement for this audit was identified by the multidisciplinary team (MDT) and Trust approval was obtained...
September 2016: Archives of Disease in Childhood
R E Selekman, I E Allen, H L Copp
INTRODUCTION: Urinary tract infection (UTI) affects 10% of girls and 3% of boys by age 16. Both the American Academy of Pediatrics and National Institute for Health and Clinical Excellence Guidelines recommend urine testing prior to initiation of antibiotic treatment and the use of local antibiograms to guide empiric antibiotic therapy. Urine culture results not only provide the opportunity to halt empiric therapy if there is no bacterial growth, but also allow for tailoring of broad-spectrum therapy...
July 5, 2016: Journal of Pediatric Urology
Sarah Bienenfeld, Laura G Rodriguez-Riesco, Kent D Heyborne
OBJECTIVE: To estimate the frequency and reasons for inadequate group B streptococci (GBS) prophylaxis at our institution and to estimate what proportion of cases can be avoided with perfect protocol adherence. METHODS: This was a retrospective cohort study of neonates born to GBS-colonized women who received inadequate prophylaxis between April 30, 2013, and May 1, 2014. The maternal chart was analyzed to categorize each case as avoidable (adequate time on labor and delivery to receive antibiotics 4 hours before birth and β-lactam antibiotic-eligible) or unavoidable and to determine whether a violation of the 2010 Centers for Disease Control and Prevention (CDC) protocol (delayed or incorrect antibiotics) occurred...
September 2016: Obstetrics and Gynecology
Joost M Costerus, Matthijs C Brouwer, Merijn W Bijlsma, Michael W Tanck, Arie van der Ende, Diederik van de Beek
OBJECTIVES: To study the impact of an evidence-based guideline on the management of community-acquired bacterial meningitis. The guideline stresses the importance of cranial imaging before LP in selected patients based on clinical criteria and early treatment with amoxicillin and a third generation cephalosporin for adults with suspected community-acquired bacterial meningitis. METHODS: We performed an interrupted time series analysis using data from a Dutch nationwide prospective cohort study from 2006 to 2015...
July 30, 2016: Clinical Microbiology and Infection
Maher Almatar, Gregory M Peterson, Angus Thompson, Duncan McKenzie, Tara Anderson, Syed Tabish R Zaidi
BACKGROUND: Compliance with community-acquired pneumonia (CAP) guidelines remains poor despite a substantial body of evidence indicating that guideline-concordant care improves patient outcomes. The aim of this study was to compare the relative effectiveness of a general educational and a targeted emergency department intervention on improving physicians' concordance with CAP guidelines. METHODS: Two distinct interventions were implemented over specific time periods...
2016: PloS One
Nasia Safdar, Jackson S Musuuza, Anping Xie, Ann Schoofs Hundt, Matthew Hall, Kenneth Wood, Pascale Carayon
BACKGROUND: Guidelines from the Infectious Diseases Society of America/The American Thoracic Society (IDSA/ATS) provide recommendations for diagnosis and treatment of ventilator-associated pneumonia (VAP). However, the mere presence of guidelines is rarely sufficient to promote widespread adoption and uptake. Using the Systems Engineering Initiative for Patient Safety (SEIPS) model framework, we undertook a study to understand barriers and facilitators to the adoption of the IDSA/ATS guidelines...
2016: BMC Infectious Diseases
Sowndarya Visalachy, Kennedy Kumar Palraj, Sridharan Sathyamoorthy Kopula, Uma Sekar
INTRODUCTION: Maximal contact between the patients and Health Care Workers (HCWs) happens in the Intensive Care Units (ICU). Control of nosocomial infections requires compliance with hand hygiene and contamination free surfaces. AIM: To determine the colonization of potential pathogens in the hands of HCWs and frequent contacted environmental surfaces. MATERIALS AND METHODS: A cross sectional study was conducted between September 2012 and May 2013 at Sri Ramachandra Medical College and Hospital...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
Kevin L Smith, Dang Tran, Bonnie L Westra
BACKGROUND: Studies demonstrate poor guideline adherence by health care providers for the treatment of upper respiratory infections, particularly acute bacterial rhinosinusitis (ABRS), in the appropriate prescribing of antibiotic medications. OBJECTIVE: The purpose of this quality improvement project was to evaluate the effect of implementing interventions for improving adherence to a clinical practice guideline for the management of ABRS for patients treated in the e-visit setting...
2016: Applied Clinical Informatics
Adel Alothman, Abdullah Algwizani, Mohammed Alsulaiman, Abdullah Alalwan, Salih Binsalih, Mohammad Bosaeed
INTRODUCTION: Antibiotics are essential and abundantly prescribed in hospitals because of their effectiveness and lifesaving benefits. However, the unnecessary use of antibiotics has been observed in earlier studies, and it has persisted through recent years as a major issue since it is one of the leading causes of antibiotic resistance. The increase in antibiotic resistance nowadays is one of the most critical concerns in global public health around the world. The objective of this study was to evaluate the knowledge and perceptions related to antibiotic prescription among physicians at our medical centers...
2016: Infectious Diseases
Jared Sheley, Dave Willman, Julie Downen, Scott Bergman
BACKGROUND: Bacterial meningitis is responsible for significant morbidity and mortality, but early appropriate therapy is expected to improve outcomes. National treatment guidelines were published in 2004, but no assessment of their utilization in the U.S. has been reported. OBJECTIVES: To measure adherence to meningitis treatment guidelines and describe patient outcomes in relation to recommended antibiotic and dexamethasone use. METHODS: Retrospective chart reviews were performed on patients with bacterial meningitis who presented to emergency departments at two community teaching hospitals...
July 2016: P & T: a Peer-reviewed Journal for Formulary Management
Anna L Kenchington, Ronald F Lamont
INTRODUCTION: Early onset neonatal Group B streptococcal disease is preventable. Intrapartum antibiotic prophylaxis has resulted in a significant reduction in neonatal mortality and morbidity. National guidelines for the selection of women eligible for intrapartum antibiotic prophylaxis, whether screening-based or risk-based, differ according to the local burden of disease. Despite the introduction of intrapartum antibiotic prophylaxis, there remains a significant burden of disease, which can be resolved by better adherence to guidelines, rapid identification of maternal colonization or in the future, vaccination...
July 6, 2016: Expert Review of Vaccines
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