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https://www.readbyqxmd.com/read/28109184/comparative-cardiovascular-risks-of-dipeptidyl-peptidase-4-inhibitors-with-other-2-nd-and-3-rd-line-antidiabetic-drugs-in-patients-with-type-2-diabetes
#1
Huang-Tz Ou, Kai-Cheng Chang, Chung-Yi Li, Jin-Shang Wu
AIMS: Dipeptidyl peptidase-4 inhibitors (DPP4i) are suggested as 2(nd) and 3(rd) add-on antidiabetic treatment for type 2 diabetes. Previous studies only assessed cardiovascular effects of DPP4i as 2(nd) line treatment, included sulfonylurea as only one comparator, and yielded inconclusive results on the risk of heart failure. This study therefore evaluated comparative cardiovascular risks of DPP4i with other 2(nd) and 3(rd) line antidiabetic drugs. METHODS: Based on a large nation-wide diabetic cohort, 113,051 patients with type 2 diabetes newly on metformin-based dual or triple therapy were identified in 2009-2011 and followed until death or 2013...
January 21, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28109151/-tacrolimus-down-regulates-the-mrna-levels-of-il-17-and-il-23-in-the-muscle-tissues-of-mice-with-experimental-autoimmune-myositis
#2
Xiaojia Tian, Fangyuan He, Hongge Jia, Hongya Zhang
Objective To measure the expression levels of interleukin-17 (IL-17) and IL-23 mRNAs in the muscle tissue of the mice with experimental autoimmune myositis (EAM), and investigate the impact of tacrolimus (TAC) treatment on the mRNA levels of IL-17 and IL-23 and its therapeutic effect in EAM mice. Methods Fifteen female BALB/c mice were divided randomly into three groups, a normal control group, an EAM model group and a TAC-treated group. HE staining was used to observe the pathological changes for evaluating muscle inflammation of EAM mice...
February 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28109142/-changes-and-role-evaluation-of-tnf-%C3%AE-and-il-1%C3%AE-in-lung-tissues-of-ards-mice
#3
Jianing Liang, Qianqian Zhou, Tianxiang Zhang, Xiaosu Wang, Liqiang Song
Objective To study the expression levels of TNF-α and IL-1β in the lung tissues of acute respiratory distress syndrome (ARDS) mice and their relationships with the severity of lung injury in the mice. Methods A mouse model of ARDS was induced by lipopolysaccharide (LPS). The morphological changes of lung tissue was observed by HE staining, and the lung injury score was calculated. Quantitative real-time PCR was employed to detect the mRNA expression levels of TNF-α and IL-1β in lung tissues and ELISA was performed to test the protein levels of TNF-α and IL-1β in bronchoalveolar lavage fluid (BALF)...
February 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28109111/-efficacy-of-high-versus-low-plasma-red-blood-cell-ratio-resuscitation-in-patients-with-severe-trauma-requiring-massive-blood-transfusion-a-meta-analysis
#4
Fang Yu, Tao Zhong, Gang Wu
OBJECTIVE: To evaluate the efficacy of high (≥1:2) and low (<1:2) plasma: red blood cell (RBC) ratio resuscitation in patients with severe trauma requiring massive blood transfusion. METHODS: The databases including the Cochrane Library, Pubmed, Web of Science, and EMBASE were systemically searched for relevant studies published between January, 2009 and April, 2016. The selection of studies, assessment of methodological quality and data extraction were performed by two researchers independently according to the inclusion and exclusion criteria...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28109107/-efficacy-of-repetitive-transcranial-magnetic-stimulation-for-alleviating-clinical-symptoms-and-suicidal-ideation-in-elderly-depressive-patients-a-randomized-controlled-trial
#5
Bi-Yong Qin, Li-Lei Dai, Yan Zheng
OBJECTIVE: To assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) for alleviating the clinical symptoms and suicidal ideation in elderly patients with depression. METHODS: A total of 178 elderly depressive patients with suicidal ideation were randomized into rTMS treatment group (n=80) and control group (n=98) and treated with rTMS or sham rTMS treatment for 4 weeks in addition to conventional therapy with medications. The 24-item Hamilton Depression Scales (HAMD) and Self-rating Idea of Suicide Scale (SIOSS) were used to assess the severity of depression and the risk of suicide at the baseline and after 2 and 4 weeks of treatment...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28109100/-claudin-3-expression-in-colorectal-carcinoma-and-its-significance
#6
Jing-Yi Li, Fang Xie, Xiao-Ping Xu, Juan-Juan Ma, Dai-Chao Zhou, Yan Liao, Jing Tang, Qian Xie, Lan Bai, Qing-Zhen Nan
OBJECTIVE: To investigate the expression of claudin-3 in colorectal carcinoma and its association with the occurrence, progression and prognosis of colorectal cancer. METHODS: Forty surgical specimens of colorectal carcinoma and 22 adjacent normal tissues resected between October, 2010 and January, 2013 at Nanfang Hospital were examined for claudin-3 expression using immunohistochemistry, which was analyzed in association with the clinicopathological parameters and the survival of the patients...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28109097/-mucosal-healing-in-different-intestinal-segments-in-patients-receiving-infliximab-treatment-for-small-bowel-crohn-s-disease
#7
Zhen-Hao Zhu, Chen Qiu, Ming Zhang, Zhao Chen, Cheng Xiang, Xin-Ying Wang
OBJECTIVE: To evaluate the mucosal healing in the terminal ileum, colon and small bowel in patients receiving infliximab treatment for small bowel Crohn's disease (SBCD). METHODS: The clinical data of 18 patients with SBCD treated with infliximab were analyzed for laboratory findings (routine blood tests, C-reative protein, and albumin), Crohn's disease activity index (CDAI), Lewis score (LS), Crohn's disease simplified endoscopic score (SES-CD) and adverse effects before and after 30 weeks of infliximab treatment...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28109060/morphine-pharmacodynamics-in-mechanically-ventilated-preterm-neonates-undergoing-endotracheal-suctioning
#8
P A Välitalo, Ehj Krekels, M van Dijk, Shp Simons, D Tibboel, Caj Knibbe
To date, morphine pharmacokinetics (PKs) are well quantified in neonates, but results about its efficacy are ambiguous. This work presents an analysis of a previously published study on pain measurements in mechanically ventilated preterm neonates who received either morphine or placebo to improve comfort during invasive ventilation. The research question was whether morphine reduces the pain associated with endotracheal or nasal suctioning before, during, and after suctioning. Because these neonates cannot verbalize their pain levels, pain was assessed on the basis of several validated pain measurement instruments (i...
January 21, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28109050/low-transferrin-and-high-ferritin-concentrations-are-associated-with-worse-outcome-in-acute-liver-failure
#9
Olympia Anastasiou, Julia Kälsch, Mahdi Hakmouni, Ozlem Kucukoglu, Dominik Heider, Johannes Korth, Paul Manka, Jan-Peter Sowa, Lars Bechmann, Fuat Saner, Andreas Paul, Guido Gerken, Hideo Baba, Ali Canbay
BACKGROUND & AIMS: Serum ferritin and transferrin have been identified as prognostic markers in patients with chronic diseases. In the present study we investigated if these parameters can predict outcome in patients with acute liver failure. METHODS: 102 consecutive patients with acute liver failure were retrospectively analyzed. The patients were grouped by outcome: spontaneous recovery vs. liver transplantation and/or death; or survival vs. death. Routine laboratory parameters, transferrin and ferritin concentrations in serum, and anthropomorphic data collected on admission were analyzed...
January 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28109045/misoprostol-for-cervical-priming-prior-to-hysteroscopy-in-postmenopausal-and-premenopausal-nulliparous-women-a-multicentre-randomised-placebo-controlled-trial
#10
M L Tasma, M Louwerse, W J Hehenkamp, P M Geomini, M Y Bongers, S Veersema, P J van Kesteren, E Tromp, J A Huirne, G C Graziosi
OBJECTIVE: To evaluate the reduction of pain by Misoprostol compared to placebo prior to hysteroscopy in postmenopausal and premenopausal nulliparous women. DESIGN: Randomised multicentre double-blind placebo controlled trial. SETTING: Two Dutch teaching hospitals and one Dutch university medical centre. POPULATION: Postmenopausal and premenopausal nulliparous women undergoing office hysteroscopy. METHODS: Patients were randomised to receive either 400 mcg Misoprostol or placebo 12 and 24 hours before hysteroscopy...
January 21, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28109036/a-propensity-score-matched-comparative-study-between-paclitaxel-coated-balloon-and-everolimus-eluting-stents-for-the-treatment-of-small-coronary-vessels
#11
Francesco Giannini, Azeem Latib, Marco B Ancona, Charis Costopoulos, Neil Ruparelia, Alberto Menozzi, Fausto Castriota, Antonio Micari, Alberto Cremonesi, Francesco De Felice, Alfredo Marchese, Maurizio Tespili, Patrizia Presbitero, Gregory A Sgueglia, Francesca Buffoli, Corrado Tamburino, Ferdinando Varbella, Antonio Colombo
OBJECTIVES: To compare the long-term clinical outcomes of paclitaxel drug-coated-balloons (DCB) and everolimus-eluting-stents (EES) following the treatment of de novo small vessel coronary artery disease. BACKGROUND: It is currently unclear whether treatment of de novo small vessel coronary disease with DCB is comparable to second generation drug-eluting stents, which are the current standard of care. METHODS: The present study enrolled 90 patients with small vessel coronary disease from the DCB treatment arm of the BELLO (Balloon Elution and Late Loss Optimization) trial and 2,000 patients treated with EES at the San Raffaele Scientific Institute...
January 21, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28109027/amplitude-integrated-electroencephalography-can-predict-neurodevelopmental-outcome-at-12-months-of-corrected-age-in-very-preterm-infants
#12
Elisabeth Ralser, Vera Neubauer, Ulrike Pupp-Peglow, Ursula Kiechl-Kohlendorfer, Elke Griesmaier
AIM: It is difficult to find diagnostic tools than can reliably predict neurodevelopmental outcomes in very preterm infants in clinical practice. This study evaluated whether amplitude-integrated electroencephalography predicted neurodevelopmental outcome in preterm infants when they reached 12 months of corrected age. METHODS: Between October 2007 and December 2013 we studied 232 preterm infants (51% male) at Innsbruck Medical University Hospital, Austria. Their mean birth weight was 1,264 grams and their mean gestational age was 29...
January 20, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28108975/3d-printed-soft-tissue-physical-models-of-renal-malignancies-for-individualized-surgical-simulation-a-feasibility-study
#13
Michael M Maddox, Allison Feibus, James Liu, Julie Wang, Raju Thomas, Jonathan L Silberstein
To construct patient-specific physical three-dimensional (3D) models of renal units with materials that approximates the properties of renal tissue to allow pre-operative and robotic training surgical simulation, 3D physical kidney models were created (3DSystems, Rock Hill, SC) using computerized tomography to segment structures of interest (parenchyma, vasculature, collection system, and tumor). Images were converted to a 3D surface mesh file for fabrication using a multi-jet 3D printer. A novel construction technique was employed to approximate normal renal tissue texture, printers selectively deposited photopolymer material forming the outer shell of the kidney, and subsequently, an agarose gel solution was injected into the inner cavity recreating the spongier renal parenchyma...
January 20, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28108953/predictors-of-early-restenosis-after-intracardiac-echocardiography-guided-antegrade-balloon-aortic-valvuloplasty-in-high-risk-or-inoperable-patients
#14
Shinobu Hosokawa, Yoshikazu Hiasa, Akiho Seno, Tatuo Yasuoka, Tomoko Izumi, Riyo Ogura
Antegrade balloon aortic valvuloplasty (BAV) may be more effective than retrograde BAV. However, early restenosis is found inconstantly within three months after BAV. To evaluate the factor of ER after intracardiac echocardiogram (ICE) guided Antegrade BAV, fifty patients with severe aortic stenosis (AS) underwent BAV procedures with ICE. ER was defined as mean aortic valve pressure gradient (PG) >40 mmHg. During one-year follow-up period, 6 patients died and 2 patients underwent aortic valve replacement...
January 20, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28108922/association-between-heavy-metal-and-metalloid-levels-in-topsoil-and-cancer-mortality-in-spain
#15
Olivier Núñez, Pablo Fernández-Navarro, Iván Martín-Méndez, Alejandro Bel-Lan, Juan F Locutura Rupérez, Gonzalo López-Abente
Spatio-temporal cancer mortality studies in Spain have revealed patterns for some tumours which display a distribution that is similar across the sexes and persists over time. Such characteristics would be common to tumours that shared risk factors, including the geochemical composition of the soil. The aim of this study was to assess the possible association between heavy metal and metalloid levels in topsoil (upper soil horizon) and cancer mortality in mainland Spain. Ecological cancer mortality study at a municipal level, covering 861,440 cancer deaths (27 different tumour locations) in 7917 Spanish mainland towns, from 1999 to 2008...
January 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28108907/peripapillary-retinal-nerve-fiber-layer-and-ganglion-cell-inner-plexiform-layer-thickness-in-adult-onset-familial-mediterranean-fever
#16
Sait Alim, Mehmet Esen, Ayşe Kevser Demir, Selim Demir, Hüseyin Ortak, Alper Güneş, Tufan Alatli, Helin Deniz Demir
OBJECTIVE: The purpose of the present study was to evaluate the thickness of the peripapillary retinal nerve fiber layer (RNFL) and retinal ganglion cell-inner plexiform layer (GCIPL) in adult-onset familial Mediterranean fever (FMF). METHODS: Forty two adult-onset FMF patients and forty two healthy controls were included in the present study. Detailed ocular examination was performed, and then the thickness of the peripapillary RNFL and GCIPL was measured by Spectral domain optical coherence tomography...
January 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28108876/concordance-between-self-report-and-performance-based-measures-of-everyday-functioning-in-hiv-associated-neurocognitive-disorders
#17
Talia N Shirazi, Angela C Summers, Bryan R Smith, Sally R Steinbach, Suad Kapetanovic, Avindra Nath, Joseph Snow
Self-report is typically used to differentiate between asymptomatic neurocognitive impairment (ANI) and mild neurocognitive disorder (MND) in the assessment of HIV-associated neurocognitive disorders (HAND). Yet, it is unclear whether the lack of self-reported functional impairments in individuals with ANI is indicative of a genuine absence of functional impairment, or of inaccurate self-reports. In the present study, we examined the relationship between previously validated self-report (patient's assessment of own functioning inventory; instrumental activities of daily living inventory) and performance-based (the Texas Functional Living Scale) measures of functional abilities in 112 virologically-controlled HIV-infected, and 40 well-matched, HIV-uninfected participants...
January 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28108872/neighborhood-disorder-and-physical-activity-among-older-adults-a-longitudinal-study
#18
Stephen J Mooney, Spruha Joshi, Magdalena Cerdá, Gary J Kennedy, John R Beard, Andrew G Rundle
Neighborhood physical disorder-the visual indications of neighborhood deterioration-may inhibit outdoor physical activity, particularly among older adults. However, few previous studies of the association between neighborhood disorder and physical activity have focused on this sensitive population group, and most have been cross-sectional. We examined the relationship between neighborhood physical disorder and physical activity, measured using the Physical Activity Scale for the Elderly (PASE), in a three-wave longitudinal study of 3497 New York City residents aged 65-75 at baseline weighted to be representative of the older adult population of New York City...
January 20, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28108856/diagnosis-and-management-for-trigeminal-neuralgia-caused-solely-by-venous-compression
#19
Takuro Inoue, Hisao Hirai, Ayako Shima, Fumio Suzuki, Takanori Fukushima, Masayuki Matsuda
BACKGROUND: Trigeminal neuralgia (TN) caused solely by venous compression is uncommon. An appropriate vein management protocol for microvascular decompression (MVD) has not been established. We evaluated the management of veins for TN solely due to venous involvement. METHOD: We analyzed 31 patients with TN in whom only veins were manipulated during MVD. The culprit veins smaller in diameter than the vein of the cerebellopontine fissure (VCPF) were coagulated and divided in 20 patients (divided group), while transposition was performed for larger veins in the remaining 11 patients (non-divided group)...
January 20, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28108850/baicalein-promotes-neuronal-and-behavioral-recovery-after-intracerebral-hemorrhage-via-suppressing-apoptosis-oxidative-stress-and-neuroinflammation
#20
Ning Wei, Yinghai Wei, Binru Li, Linlin Pang
Intracerebral hemorrhage (ICH) is an important public health problem in neurology, which is not only associated with high mortality but also leading to disability. Yet no satisfactory treatment has been developed. The secondary injury that resulted from a number of self-destructive processes such as neuroinflammation, apoptosis and oxidative stress, is the key factor contributing to ICH-induced brain damage. Baicalein has been proved to improve neuronal functional recovery in rat model of subarachnoid hemorrhage and ischemic brain damage...
January 21, 2017: Neurochemical Research
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