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https://www.readbyqxmd.com/read/28212183/cxcl12-cxcr4-signaling-contributes-to-the-pathogenesis-of-opioid-tolerance-a-translational-study
#1
Chih-Peng Lin, Kai-Hsiang Kang, Huang-Ju Tu, Ming-Yueh Wu, Tzu-Hung Lin, Houng-Chi Liou, Wei-Zen Sun, Wen-Mei Fu
BACKGROUND: Long-term opioid therapy for chronic pain may lead to analgesic tolerance, especially when administered intrathecally, thus preventing adequate pain relief. Discovering drug targets to treat opioid tolerance using a mechanism-based approach targeting opioid-induced neuroinflammation provides new therapeutic opportunities. In this study, we provide translational evidence that CXCL12/CXCR4 signaling contributes to the pathogenesis of opioid tolerance. METHODS: The CXCL12 levels in the cerebrospinal fluid of opioid-tolerant patients were compared with those of opioid-naive subjects...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28212153/new-therapies-for-the-prevention-and-treatment-of-exacerbations-of-bronchiectasis
#2
Hani Abo-Leyah, James D Chalmers
PURPOSE OF REVIEW: Exacerbations of bronchiectasis have a major impact on quality of life, healthcare costs, and long-term risk of complications. Preventing exacerbations is one of the major goals of treatment. Bronchiectasis is increasingly recognized and the impact of bronchiectasis exacerbations on daily clinical practice is also increasing. RECENT FINDINGS: Preventing bronchiectasis exacerbations are dependent on appropriate risk assessment, identifying the patients at highest risk to rationally target preventive therapies...
February 16, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28212072/neural-network-based-solutions-for-stochastic-optimal-control-using-path-integrals
#3
Karthikeyan Rajagopal, Sivasubramanya Nadar Balakrishnan, Jerome R Busemeyer
In this paper, an offline approximate dynamic programming approach using neural networks is proposed for solving a class of finite horizon stochastic optimal control problems. There are two approaches available in the literature, one based on stochastic maximum principle (SMP) formalism and the other based on solving the stochastic Hamilton-Jacobi-Bellman (HJB) equation. However, in the presence of noise, the SMP formalism becomes complex and results in having to solve a couple of backward stochastic differential equations...
March 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28212007/catalytic-enantioselective-transformations-involving-c-h-bond-cleavage-by-transition-metal-complexes
#4
Christopher G Newton, Shou-Guo Wang, Caio C Oliveira, Nicolai Cramer
The development of new methods for the direct functionalization of unactivated C-H bonds is ushering in a paradigm shift in the field of retrosynthetic analysis. In particular, the catalytic enantioselective functionalization of C-H bonds represents a highly atom- and step-economic approach toward the generation of structural complexity. However, as a result of their ubiquity and low reactivity, controlling both the chemo- and stereoselectivity of such processes constitutes a significant challenge. Herein we comprehensively review all asymmetric transition-metal-catalyzed methodologies that are believed to proceed via an inner-sphere-type mechanism, with an emphasis on the nature of stereochemistry generation...
February 17, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28211693/a-probabilistic-finite-state-logic-machine-realized-experimentally-on-a-single-dopant-atom
#5
Barbara Fresch, Juanita Bocquel, Sven Rogge, Raphael D Levine, Francoise Remacle
Exploiting the potential of nanoscale devices for logic processing requires the implementation of computing functionalities departing from the conventional switching paradigm. We report on the design and the experimental realisation of a probabilistic finite state machine in a single phosphorus donor atom placed in a silicon matrix electrically addressed and probed by Scanning Tunnelling Spectroscopy (STS). The single atom logic unit simulates the flow of visitors in a maze whose topology is determined by the dynamics of the electronic transport through the states of the dopant...
February 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28211489/sleep-supports-the-slow-abstraction-of-gist-from-visual-perceptual-memories
#6
Nicolas D Lutz, Susanne Diekelmann, Patricia Hinse-Stern, Jan Born, Karsten Rauss
Sleep benefits the consolidation of individual episodic memories. In the long run, however, it may be more efficient to retain the abstract gist of single, related memories, which can be generalized to similar instances in the future. While episodic memory is enhanced after one night of sleep, effective gist abstraction is thought to require multiple nights. We tested this hypothesis using a visual Deese-Roediger-McDermott paradigm, examining gist abstraction and episodic-like memory consolidation after 20 min, after 10 hours, as well as after one year of retention...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211449/translational-use-of-event-related-potentials-to-assess-circuit-integrity-in-asd
#7
REVIEW
Meera E Modi, Mustafa Sahin
Deficits in social cognition are the defining characteristic of autism spectrum disorder (ASD). Social cognition requires the integration of several neural circuits in a time-sensitive fashion, so impairments in social interactions could arise as a result of alterations in network connectivity. Electroencephalography (EEG) has revealed abnormalities in event related potentials (ERPs) evoked by auditory and visual sensory stimuli in humans with ASD, indicating disruption of neural connectivity. Similar abnormalities in sensory-evoked ERPs have been observed in animal models of ASD, suggesting that ERPs have the potential to provide a translational biomarker of the disorder...
February 17, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28211025/participants-shift-response-deadlines-based-on-list-difficulty-during-reading-aloud-megastudies
#8
Michael J Cortese, Maya M Khanna, Robert Kopp, Jonathan B Santo, Kailey S Preston, Tyler Van Zuiden
We tested the list homogeneity effect in reading aloud (e.g., Lupker, Brown, & Colombo, 1997) using a megastudy paradigm. In each of two conditions, we used 25 blocks of 100 trials. In the random condition, words were selected randomly for each block, whereas in the experimental condition, words were blocked by difficulty (e.g., easy words together, etc.), but the order of the blocks was randomized. We predicted that standard factors (e.g., frequency) would be more predictive of reaction times (RTs) in the blocked than in the random condition, because the range of RTs across the experiment would increase in the blocked condition...
February 16, 2017: Memory & Cognition
https://www.readbyqxmd.com/read/28210995/checkpoint-inhibitors-for-the-treatment-of-renal-cell-carcinoma
#9
REVIEW
Pooja Ghatalia, Matthew Zibelman, Daniel M Geynisman, Elizabeth R Plimack
The advent of checkpoint inhibitors has revolutionized systemic therapy for many malignancies, including renal cell carcinoma (RCC) where multiple PD-1, PD-L1, and CTLA-4 inhibitors have demonstrated responses and improved survival for patients in clinical trials. Durable benefit with manageable toxicity can be achieved with these agents-but unfortunately for only a minority of individuals. Efforts are ongoing to understand mechanisms driving the response and resistance to checkpoint inhibitors in order to personalize therapy and extend benefit to more patients...
January 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28210994/factors-related-to-the-quality-of-life-of-older-prisoners
#10
Stefaan De Smet, Liesbeth De Donder, Denis Ryan, Sofie Van Regenmortel, Dorien Brosens, Stijn Vandevelde
PURPOSES: There is evidence of an increasing emphasis on the relevance of the quality of life-paradigm as an outcome measure for clients in geriatric, forensic, as well as correctional care. This paper aims to explore to what extent variables that were categorized according to the main areas of the Good Lives Model ('the self', 'the body' and 'social life') are related to the quality of life domains of older imprisoned offenders. METHODS: Data were collected by means of a structured questionnaire administered in individual interviews with 93 older prisoners aged 60 years and over in 16 prisons of the Dutch-speaking region in Belgium...
February 16, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28210871/repeated-doses-of-cardiac-mesenchymal-cells-are-therapeutically-superior-to-a-single-dose-in-mice-with-old-myocardial-infarction
#11
Yiru Guo, Marcin Wysoczynski, Yibing Nong, Alex Tomlin, Xiaoping Zhu, Anna M Gumpert, Marjan Nasr, Senthikumar Muthusamy, Hong Li, Michael Book, Abdur Khan, Kyung U Hong, Qianhong Li, Roberto Bolli
We have recently demonstrated that repeated administrations of c-kit(POS) cardiac progenitor cells (CPCs) have cumulative beneficial effects in rats with old myocardial infarction (MI), resulting in markedly greater improvement in left ventricular (LV) function compared with a single administration. To determine whether this paradigm applies to other species and cell types, mice with a 3-week-old MI received one or three doses of cardiac mesenchymal cells (CMCs), a novel cell type that we have recently described...
March 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28210819/evidence-for-instructions-based-updating-of-task-set-representations-the-informed-fadeout-effect
#12
Maayan Pereg, Nachshon Meiran
The cognitive system can be updated rapidly and efficiently to maximize performance in cognitive tasks. This paper used a task-switching task to explore updating at the level of the plausible task-sets held for future performance. Previous research suggested a "fadeout effect", performance improvement when moving from task-switching context to single-task context, yet this effect could reflect passive learning rather than intentional control. In a novel "informed fadeout paradigm", one of two tasks was canceled for a certain number of trials and participants were informed or uninformed regarding task cancelation...
February 16, 2017: Psychological Research
https://www.readbyqxmd.com/read/28210767/crohn-s-disease-diagnosis-treatment-approach-and-management-paradigm-what-the-radiologist-needs-to-know
#13
Parakkal Deepak, Sang Hyoung Park, Eric C Ehman, Stephanie L Hansel, Jeff L Fidler, David H Bruining, Joel G Fletcher
Crohn's disease is one of the major subtypes of idiopathic inflammatory bowel disease and is characterized by chronic transmural intestinal inflammation of the gastrointestinal tract anywhere from mouth to the anus, with a predilection for the small bowel. Cross-sectional imaging with computed tomography and magnetic resonance enterography plays a key role in confirming diagnosis, identifying and managing complications, assessing disease severity, and identifying response to medical therapy. This review will focus on the role of radiologists in the diagnosis and assessment of Crohn's disease...
February 16, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28210263/a-paradigm-shift-on-the-question-of-b-cells-in-transplantation-recent-insights-on-regulating-the-alloresponse
#14
REVIEW
Daniel J Firl, Gilles Benichou, James I Kim, Heidi Yeh
B lymphocytes contribute to acute and chronic allograft rejection through their production of donor-specific antibodies (DSAs). In addition, B cells present allopeptides bound to self-MHC class II molecules and provide costimulation signals to T cells, which are essential to their activation and differentiation into memory T cells. On the other hand, both in laboratory rodents and patients, the concept of effector T cell regulation by B cells is gaining traction in the field of transplantation. Specifically, clinical trials using anti-CD20 monoclonal antibodies to deplete B cells and reverse DSA had a deleterious effect on rates of acute cellular rejection; a peculiar finding that calls into question a central paradigm in transplantation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28210216/flavor-dependent-retention-of-remote-food-preference-memory
#15
Aditya Singh, Suraj Kumar, Vikram Pal Singh, Asish Das, J Balaji
Social Transmission of Food Preference (STFP) is a single trial non-aversive learning task that is used for testing non-spatial memory. This task relies on an accurate estimate of a change in food preference of the animals following social demonstration of a novel flavor. Conventionally this is done by providing two flavors of powdered food and later estimating the amount of food consumed for each of these flavors in a defined period of time. This is achieved through a careful measurement of leftover food for each of these flavors...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28210209/lactate-shuttles-in-neuroenergetics-homeostasis-allostasis-and-beyond
#16
REVIEW
Shayne Mason
Understanding brain energy metabolism-neuroenergetics-is becoming increasingly important as it can be identified repeatedly as the source of neurological perturbations. Within the scientific community we are seeing a shift in paradigms from the traditional neurocentric view to that of a more dynamic, integrated one where astrocytes are no longer considered as being just supportive, and activated microglia have a profound influence. Lactate is emerging as the "good guy," contrasting its classical "bad guy" position in the now superseded medical literature...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28209926/characterization-of-the-influence-of-age-on-gabaa-and-glutamatergic-mediated-functions-in-the-dorsolateral-prefrontal-cortex-using-paired-pulse-tms-eeg
#17
Yoshihiro Noda, Reza Zomorrodi, Robin F H Cash, Mera S Barr, Faranak Farzan, Tarek K Rajji, Robert Chen, Zafiris J Daskalakis, Daniel M Blumberger
Gamma-aminobutyric acid (GABA)ergic and glutamatergic neurotransmissions in the prefrontal cortex decreases with age. Further, cognitive function mediated through the dorsolateral prefrontal cortex (DLPFC) also declines with age. Although neuroimaging studies have demonstrated decreased levels of these substances, direct neurophysiological data investigating the effect of aging in the DLPFC in human subjects is lacking. The advent of transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG) has allowed for the assessment of functional neurotransmission in vivo...
February 16, 2017: Aging
https://www.readbyqxmd.com/read/28209604/birth-size-risk-factors-across-life-and-cognition-in-late-life-protocol-of-prospective-longitudinal-follow-up-of-the-mynah-mysore-studies-of-natal-effects-on-ageing-and-health-cohort
#18
Murali Krishna, G Mohan Kumar, S R Veena, G V Krishnaveni, Kalyanaraman Kumaran, Samuel Christaprasad Karat, Patsy Coakley, Clive Osmond, John R M Copeland, Giriraj Chandak, Dattatray Bhat, Mathew Varghese, Martin Prince, Caroline Fall
INTRODUCTION: For late-life neurocognitive disorders, as for other late-life chronic diseases, much recent interest has focused on the possible relevance of Developmental Origins of Health and Disease (DOHaD). Programming by undernutrition in utero, followed by overnutrition in adult life may lead to an increased risk, possibly mediated through cardiovascular and metabolic pathways. This study will specifically examine, if lower birth weight is associated with poorer cognitive functioning in late life in a south Indian population...
February 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28209521/impaired-visual-competition-in-patients-with-homonymous-visual-field-defects
#19
A C Geuzebroek, A V van den Berg
Intense visual training can lead to partial recovery of visual field defects caused by lesions of the primary visual cortex. However, the standard visual detection and discrimination tasks, used to assess this recovery process tend to ignore the complexity of the natural visual environment, where multiple stimuli continuously interact. Visual competition is an essential component for natural search tasks and detecting unexpected events. Our study focused on visual decision-making and to what extent the recovered visual field can compete for attention with the 'intact' visual field...
February 13, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28209489/the-systematic-error-in-the-estimation-of-fetal-weight-and-the-underestimation-of-fetal-growth-restriction
#20
Justin R Lappen, Stephen A Myers
Fetal growth restriction (FGR) is associated with an increased risk of perinatal morbidity and mortality and has lifetime implications for the risk of chronic medical conditions. Antenatal diagnosis of fetal growth restriction (FGR) remains poor with the majority of cases remaining undiagnosed. While several factors contribute to the underdiagnosis of FGR, the error in ultrasound estimation of fetal weight (EFW) is generally not considered in clinical practice. In this commentary, we suggest that the intrinsic, or systematic, error in ultrasound EFW is a significant factor contributing to the underestimation of fetuses predicted to have FGR and should be incorporated into screening and surveillance recommendations...
February 13, 2017: American Journal of Obstetrics and Gynecology
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