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Mi Hye Kim, Hye Ji Lee, Jung-Chul Park, Jongki Hong, Woong Mo Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Zanthoxylum piperitum (ZP) has been used to prevent toothache in East Asia. AIM OF STUDY: In this study, we investigated the effects of ZP on periodontitis along with alveolar bone loss. MATERIALS AND METHODS: Twenty-eight male Sprague-Dawley rats were assigned into 4 groups; non-ligated (NOR), ligated and treated vehicle (CTR), ligated and treated 1mg/mL ZP (ZP1), and ligated and treated 100mg/mL ZP (ZP100)...
October 21, 2016: Journal of Ethnopharmacology
Athina M Mavridou, Esther Hauben, Martine Wevers, Evert Schepers, Lars Bergmans, Paul Lambrechts
INTRODUCTION: The aim of this study was to investigate the 3-dimensional (3D) structure and the cellular and tissue characteristics of external cervical resorption (ECR) in vital teeth and to understand the phenomenon of ECR by combining histomorphological and radiographic findings. METHODS: Twenty-seven cases of vital permanent teeth displaying ECR were investigated. ECR diagnosis was based on clinical and radiographic examination with cone-beam computed tomographic imaging...
October 21, 2016: Journal of Endodontics
M C M Conde, L A Chisini, R Sarkis-Onofre, H S Schuch, J E Nör, F F Demarco
The aim of this Scoping Study was to evaluate the survival rate and nature of tissue formed inside root canals of human Necrotic Immature Permanent Teeth (NIPT) under root canal revascularization (RCR). The search was performed in SciVerse Scopus(®) , PubMed/Medline, Web of Science(®) , BIREME and in grey literature up to November 2015. The keywords were selected using MeSH terms and DECs. Two independent reviewers scrutinized the records obtained considering specific inclusion criteria. The included studies were evaluated in accordance with a modified Arksey and O' Malley's framework...
October 22, 2016: International Endodontic Journal
H Bakhtiar, H Mirzaei, M R Bagheri, N Fani, F Mashhadiabbas, M Baghaban Eslaminejad, D Sharifi, M H Nekoofar, Pmh Dummer
OBJECTIVES: The aim of this study is to compare the effect of treated dentine matrix (TDM) and tricalcium phosphate (TCP) scaffolds on odontogenic differentiation and mineralization of dental pulp stem cells (DPSCs) in furcation perforations created in the pulp chamber floor of premolar teeth in dogs. MATERIAL AND METHODS: DPSCs were isolated and cultured from the dental pulp of the maxillary left second and third premolars of dogs. The DPSCs were loaded on TCP (SC+TCP) and TDM (SC+TDM) scaffolds and inserted into intentionally perforated pulp chamber floors of premolars in dogs; six teeth were used for each group...
October 20, 2016: Clinical Oral Investigations
Avadhesh Kumar, Shalini Kaushal, Neelu Verma, Deepti Chandra
The treatment of gingival recession defects is indicated for esthetic and functional reasons to reduce root sensitivity, to remove muscle pull, to create or augment keratinized tissue, and to prevent disease progression. The presence of sufficient amount of periosteum adjacent to gingival recession defects makes it a suitable graft. The adult human periosteum is a highly vascular connective tissue with immense regenerative potential. It contains fibroblasts, osteogenic progenitor cells, and stem cells as a result of which it has the ability to differentiate into fibroblast, osteoblast, chondrocytes, adipocytes, and skeletal myocytes...
September 2016: Journal of Oral Biology and Craniofacial Research
Philippe Gauthier, Zongdong Yu, Quynh T Tran, Fazal-Ur-Rehman Bhatti, Xiaofei Zhu, George T-J Huang
Regeneration of periodontal tissues, particularly cementum, is key to regaining periodontal attachment and health. Human periodontal ligament stem cells (hPDLSCs) have been shown to be a good cell source to regenerate periodontal tissues. However, their subpopulations and the differentiation induction in relation to cementogenic lineages is unclear. Thus, we aim to examine the expression of cementum-associated genes in PDLSC subpopulations and determine the effect of broadly used osteogenic stimulus or vitamin C (VC) on the expression of cementogenic and osteogenic genes in PDLSCs...
October 18, 2016: Cell and Tissue Research
H Y Tian, P Yu, C Y Yuan, W Zhang, Y X Qiu, D H Li, X J Liang, X Y Wang
OBJECTIVE: To compare the durability of resin-based root-surface coating material and all-in-one self-etching adhesive on root surface in vitro. METHODS: Human extracted premolars or molars with intact roots were selected. The cementum was removed using a periodontal scaler to expose root dentin. The root surface was coated with an acid-resistant nail varnish, leaving a window of 3 mm×3 mm on the exposed dentin.The window was covered with either PRG Barrier Coat (PRG) or Clearfil S3 Bond (CS3)...
October 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Elisabetta Vignudelli, Giuseppe Monaco, Maria Rosaria Antonella Gatto, Simonetta Franco, Claudio Marchetti, Giuseppe Corinaldesi
PURPOSE: Coronectomy of mandibular third molars is a procedure that still raises a number of questions. The aim of the present study was to answer one unsolved question: the periodontal healing distal to the mandibular second molar after third molar coronectomy. MATERIALS AND METHODS: A prospective cohort study was performed of 30 patients treated at the Unit of Oral and Maxillofacial Surgery of the Department of Biomedical and Neuromotor Science of the University of Bologna...
September 17, 2016: Journal of Oral and Maxillofacial Surgery
Moreangels M Mbizah, Gerhard Steenkamp, Rosemary J Groom
African wild dogs (Lycaon pictus) are endangered and their population continues to decline throughout their range. Given their conservation status, more research focused on their population dynamics, population growth and age specific mortality is needed and this requires reliable estimates of age and age of mortality. Various age determination methods from teeth and skull measurements have been applied in numerous studies and it is fundamental to test the validity of these methods and their applicability to different species...
2016: PloS One
Subashchandrabose Priya, Lakshmikanth Ramiah Madanagopaal, Venkaterwaran Sarada
The calcifying epithelial odontogenic tumor (CEOT), also known as the Pindborg tumor, is a benign locally invasive neoplasm. Common variants of CEOT include noncalcifying, Langerhans cell, bone and cementum forming and clear cell, which have a prognostic significance. Pigmented variants are known to occur in other odontogenic tumors. However, a definitive pigmented variant of CEOT has not been reported in literature so far. Here, we report the first case of pigmented Pindborg tumor arising from the maxilla in a young female...
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
Wei Yao, Xiaona Li, Bin Zhao, Genlai Du, Pengfei Feng, Weiyi Chen
OBJECTIVE: This work aims to investigate how the combination of TNF-α and cyclic stretching affects the expression of gene and protein associated with mineral metabolism in cementoblasts in vitro. DESIGN: Cementoblasts were cyclically stretched using the Flexcell tension system 4000 in the presence of 10 ng/ml TNF-α. Subsequently, the gene and protein expression CAP, Col I, BSP, OPG, RANKL and RUNX2 were detected using RT- PCR and ELISA/Western immunoblotting methods, respectively...
September 30, 2016: Archives of Oral Biology
Ensanya Ali Abou Neel, Anas Aljabo, Adam Strange, Salwa Ibrahim, Melanie Coathup, Anne M Young, Laurent Bozec, Vivek Mudera
Biomineralization is a dynamic, complex, lifelong process by which living organisms control precipitations of inorganic nanocrystals within organic matrices to form unique hybrid biological tissues, for example, enamel, dentin, cementum, and bone. Understanding the process of mineral deposition is important for the development of treatments for mineralization-related diseases and also for the innovation and development of scaffolds. This review provides a thorough overview of the up-to-date information on the theories describing the possible mechanisms and the factors implicated as agonists and antagonists of mineralization...
2016: International Journal of Nanomedicine
Omid Dianat, Fatemeh Mashhadi Abas, Payam Paymanpour, Mohammad Jafar Eghbal, Sahar Haddadpour, Nazanin Bahrololumi
BACKGROUND/AIM: Different types of scaffolds have been suggested for endodontic repair procedures. The aim of this study was to compare the outcome of procedures using blood clot versus plasma rich in growth factors (PRGF) scaffold in immature teeth with apical periodontitis in dogs. MATERIALS AND METHODS: In this in vivo animal study, 20 teeth (30 canals) with open apices were divided into two groups (n = 12): (1) blood clot and (2) PRGF. Two positive and negative control groups were also selected randomly...
September 30, 2016: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Anastasia Beketova, Nikolaos Poulakis, Athina Bakopoulou, Triantafillia Zorba, Lambrini Papadopoulou, Dimitrios Christofilos, Nikolaos Kantiranis, George A Zachariadis, Eleana Kontonasaki, Gerasimos A Kourouklis, Konstantinos M Paraskevopoulos, Petros Koidis
OBJECTIVES: Aims of this study were to investigate the optimal conditions of laser irradiation of a novel Bioactive Glass/Dental Ceramic-BP67 composite for acceleration of hydroxyapatite-HA formation and to assess cellular responses on the precipitated HA region. METHODS: BP67 (Bioactive Glass: 33.3%, Dental Ceramic: 66.7%) was fabricated by the sol-gel method. A laser assisted biomimetic-LAB process was applied to BP67 sintered specimens immersed in 1.5-times concentrated simulated body fluid-1...
September 24, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Yi Liu, Haiming Du, Yunfei Wang, Mengmeng Liu, Shijian Deng, Linlin Fan, Lili Zhang, Yao Sun, Qi Zhang
INTRODUCTION: Recent studies indicate that the osteoprotegerin (OPG)/RANKL/RANK pathway takes part in root resorption. However, the relationship between OPG and root resorption is vague. The purpose of our study was to investigate the role of OPG in root resorption. METHODS: The first molars of the mandibles of osteoprotegerin-knockout (Opg-KO) mice and wild-type (WT) mice were evaluated by micro-computed tomography, histology, and immunohistochemistry at 4, 6, 26, and 52 weeks...
October 2016: Journal of Endodontics
Noémie Staubli, Clemens Walter, Julia C Schmidt, Roland Weiger, Nicola U Zitzmann
OBJECTIVE: The aim of this systematic review was to assess the role of excess cement as risk indicator for peri-implant diseases. MATERIAL AND METHODS: A systematic literature search with the keywords peri-implant disease, peri-implant mucositis, peri-implantitis, excess cement, cemented, and screw-retained restorations was performed for articles published by June 2016 using MEDLINE and EMBASE electronic databases, complemented by hand searching. RESULTS: The included 26 publications referring to 21 study groups were published between 1999 and 2016 and comprised 945 subjects with 1010 cemented implant restorations in 10 prospective and eight retrospective studies and eight case reports/series with pronounced heterogeneity of the study designs...
September 19, 2016: Clinical Oral Implants Research
Mathieu Lemaitre, Paul Monsarrat, Vincent Blasco-Baque, Pascale Loubières, Rémy Burcelin, Louis Casteilla, Valérie Planat-Bénard, Philippe Kémoun
: : Current treatment of periodontitis is still associated with a high degree of variability in clinical outcomes. Recent advances in regenerative medicine by mesenchymal cells, including adipose stromal cells (ASC) have paved the way to improved periodontal regeneration (PD) but little is known about the biological processes involved. Here, we aimed to use syngeneic ASCs for periodontal regeneration in a new, relevant, bacteria-induced periodontitis model in mice. Periodontal defects were induced in female C57BL6/J mice by oral gavage with periodontal pathogens...
September 16, 2016: Stem Cells Translational Medicine
Sugunakar Raju Godishala Swamy, Shyam Prasad Reddy Dorankula, Keerthi Muddana
INTRODUCTION: In forensic context precise knowledge on physical and histological changes of teeth subjected to high temperatures is of great importance. Preserving fragile incinerated teeth for physical, histological and ultra structural examinations is essential in fire investigations involving the origin of fire, its cause as well as the identification of victims which relies on a thorough understanding of the structural changes in dental tissues subjected to heat. AIM: The study was conducted to evaluate the physical and ultrastructural changes seen in freshly extracted teeth when subjected to gradual heating at different temperatures using Scanning Electron Microscope (SEM)...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Zhenyu Jin, Yuan Feng, Hongwei Liu
Previous reports have mainly focused on the behavioral responses of human periodontal ligament stem cells (hPDLSCs) in interaction with tibia bone marrow stromal cells (BMSCs). However, there is little study on the biologic features of hPDLSCs under the induction of maxilla BMSCs (M-BMSCs) at different phases of osteogenic differentiation. We hypothesized that M-BMSCs undergoing osteogenic differentiation acted on the proliferation, differentiation, and bone-forming capacity of hPDLSCs. In this paper, primary hPDLSCs and human M-BMSCs (hM-BMSCs) were expanded in vitro...
October 2016: Human Cell
Ronald E Goldstein, Suruchi Lamba, Nathaniel C Lawson, Preston Beck, Robert A Oster, John O Burgess
OBJECTIVES: To measure microleakage around class V composite restorations after piezoelectric ultrasonic scaling and sonic toothbrushing. METHODS: 3 mm × 2 mm × 1.5 mm boxes were prepared on buccal and lingual surfaces of extracted molars centered on the cementum-enamel junction. Half the preparations were beveled (0.5 mm). Preparations were restored with composite and polished. Restorations on one side of the teeth were either traced with an ultrasonic scaler (60 seconds, n = 16) or brushed in a sonic toothbrushing machine (2 hours, n = 16)...
September 9, 2016: Journal of Esthetic and Restorative Dentistry
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