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https://www.readbyqxmd.com/read/28323656/tumor-margin-assessment-with-loupe-magnification-enables-greater-histological-clearance-of-facial-basal-cell-carcinomas-compared-with-clinical-examination-alone
#1
Conor M Sugrue, Niall McInerney, Cormac W Joyce, Jack L Kelly
BACKGROUND: Surgical excision of facial basal cell carcinomas (BCCs) is a balance between oncological clearance and conservation of cosmetic and functionally sensitive tissues. OBJECTIVE: To assess if loupe magnification (LM) can enhance the visual assessment of BCC tumor margins resulting in a greater histological clearance. METHODS AND MATERIALS: This prospective study randomized patients with primary facial BCCs into preoperative tumor margin assessment with LM (study group) or clinical examination alone (control group)...
March 17, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28303000/design-of-nb-mo-40ti30ni30-alloy-membranes-for-combined-enhancement-of-hydrogen-permeability-and-embrittlement-resistance
#2
Xinzhong Li, Xiao Liang, Dongmei Liu, Ruirun Chen, Feifei Huang, Rui Wang, Markus Rettenmayr, Yanqing Su, Jingjie Guo, Hengzhi Fu
The effect of substitution of Nb by Mo in Nb40Ti30Ni30 was investigated with respect to microstructural features and hydrogen dissolution, diffusion and permeation. As-cast Nb40-xMoxTi30Ni30 (x = 0, 5, 10) alloys consist of primary bcc-Nb phase and binary eutectic (bcc-Nb + B2-TiNi). The substitution of Nb by Mo reduces the hydrogen solubility in alloys, but may increase (x = 5) or decrease (x = 10) the apparent hydrogen diffusivity and permeability. As-cast Nb35Mo5Ti30Ni30 exhibits a combined enhancement of hydrogen permeability and embrittlement resistance as compared to Nb40Ti30Ni30...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28300740/imiquimod-5-cream-for-the-treatment-of-large-nodular-basal-cell-carcinoma-at-the-medial-canthal-area
#3
Gamze Ozturk Karabulut, Pelin Kaynak, Can Ozturker, Korhan Fazil, Osman Bulut Ocak, Muhittin Taskapılı
Context (Background): Imiquimod (IMQ) 5% cream is an immunomodulatory and antitumorigenic agent, which was used as a topical treatment regimen, who had periocular basal cell carcinoma (BCC). AIM: This study aims to present three cases with large BCC at the medial canthal area treated with IMQ 5% cream. MATERIALS AND METHODS: IMQ 5% cream was used in three patients with ages 45, 49, and 73 who preferred medical treatment over surgery. Following incisional biopsy IMQ cream was used once a day, 5 times a week and the patients were followed up weekly during 12 week treatment period and monthly after the clearance of the lesion...
January 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28297142/vismodegib-therapy-for-basal-cell-carcinoma-in-an-8-year-old-chinese-boy-with-xeroderma-pigmentosum
#4
Douglas Fife, Marko A Laitinen, David J Myers, Pamela B Landsteiner
Vismodegib is an oral inhibitor of the Hedgehog signaling pathway and has been used to treat basal cell carcinoma (BCC) in adults. This article reports clearance of a nodular BCC of the nasal tip in an 8-year-old boy with xeroderma pigmentosum (XP). BCC can pose therapeutic challenges when located in areas that are not amenable to traditional therapies such as Mohs micrographic surgery or topical agents. Vismodegib was used at a dose of 150 mg/day to treat the boy's BCC. After 4 months of therapy, we achieved complete clinical clearance...
March 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28291016/comparative-study-of-crystallization-process-in-metallic-melts-using-ab-initio-molecular-dynamics-simulations
#5
Tekalign Terfa Debela, Xiaodong Wang, Qingping Cao, Dongxian Zhang, Jianzhong Jiang
The crystallization process of liquid metals is studied using ab initio molecular dynamics simulations. The evolution of short-range order during quenching in Pb and Zn liquids is compared with body-centered cubic (bcc) Nb and V, and hexagonal closed-packed (hcp) Mg. We found that the fraction and type of the short-range order depends on the system under consideration, in which the icosahedral symmetry seems to dominate in the body-centered cubic metals. Although the local atomic structures in stable liquids are similar, liquid hcp-like Zn, bcc-like Nb and V can be deeply supercooled far below its melting point before crystallization while the supercooled temperature range in liquid Pb is limited...
March 14, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28285366/nonmelanoma-skin-cancer-and-risk-of-all-cause-and-cancer-related-mortality-a-systematic-review
#6
Virginia Barton, Kent Armeson, Shalaka Hampras, Laura K Ferris, Kala Visvanathan, Dana Rollison, Anthony J Alberg
Some reports suggest that a history of nonmelanoma skin cancer (NMSC) may be associated with increased mortality. NMSCs have very low fatality rates, but the high prevalence of NMSC elevates the importance of the possibility of associated subsequent mortality from other causes. The variable methods and findings of existing studies leave the significance of these results uncertain. To provide clarity, we conducted a systematic review to characterize the evidence on the associations of NMSC with: (1) all-cause mortality, (2) cancer-specific mortality, and (3) cancer survival...
March 11, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28282174/direct-observation-of-entropic-stabilization-of-bcc-crystals-near-melting
#7
Joris Sprakel, Alessio Zaccone, Frans Spaepen, Peter Schall, David A Weitz
Crystals with low latent heat are predicted to melt from an entropically stabilized body-centered cubic symmetry. At this weakly first-order transition, strongly correlated fluctuations are expected to emerge, which could change the nature of the transition. Here we show how large fluctuations stabilize bcc crystals formed from charged colloids, giving rise to strongly power-law correlated heterogeneous dynamics. Moreover, we find that significant nonaffine particle displacements lead to a vanishing of the nonaffine shear modulus at the transition...
February 24, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28281509/-pathogenetic-bases-and-efficacy-of-slow-calcium-channel-blockers-in-the-therapy-of-recurrent-peptic-ulcer-disease-associated-with-hypertension
#8
L A Fomina, V V Chernin
AIM: To clarify blood calcium concentrations (BCCs) as an indicator of the functional state of the calcium-regulating system in the concomitant course of recurrent peptic ulcer disease (PUD) and hypertension, by comparing with the severity of a ulcerous process, with changes in regional microcirculation, and with the functions of the stomach. To elucidate the pathogenetic justification for and clinical efficacy of slow calcium channel blockers (SCCBs) in the treatment of this comorbidity...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28278482/all-digital-galvanically-coupled-bcc-receiver-resilient-to-frequency-misalignment
#9
Pengpeng Chen, Huazhong Yang, Rong Luo, Bo Zhao
It is promising for wearable devices to go to a miniature size to alleviate the load of human body. One way to miniaturize the communication nodes on human body is to remove the bulky components such as antenna and crystal. Galvanically-coupled body channel communication (GC-BCC) has a great advantage over conventional wireless communications in reducing the size of wearable devices because it reuses the monitoring electrodes for signal transmission in place of antennas. To remove the crystal as well, the receiver must be immune to different types of frequency misalignments...
March 2, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28276196/preparation-and-characterization-of-alloys-of-the-ti-15mo-nb-system-for-biomedical-applications
#10
J R S Martins Júnior, A A Matos, R C Oliveira, M A R Buzalaf, I Costa, L A Rocha, C R Grandini
In the development of new metallic biomaterials, the Ti-15Mo alloy has great prominence because of its excellent corrosion resistance and good combination of mechanical properties. In this study, the element niobium was added to the Ti-15Mo alloy, forming the Ti-15Mo-Nb system for the purpose of improving their properties and promoting its application as a biomaterial. These alloys are very promising to use as biomedical implants, because they integrate a new class of titanium alloys without the presence of aluminum and vanadium, which may cause cytotoxic effects...
March 9, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28272500/direct-3d-mapping-of-the-fermi-surface-and-fermi%C3%A2-velocity
#11
K Medjanik, O Fedchenko, S Chernov, D Kutnyakhov, M Ellguth, A Oelsner, B Schönhense, T R F Peixoto, P Lutz, C-H Min, F Reinert, S Däster, Y Acremann, J Viefhaus, W Wurth, H J Elmers, G Schönhense
We performed a full mapping of the bulk electronic structure including the Fermi surface and Fermi-velocity distribution vF(kF) of tungsten. The 4D spectral function ρ(EB; k) in the entire bulk Brillouin zone and 6 eV binding-energy (EB) interval was acquired in ∼3 h thanks to a new multidimensional photoemission data-recording technique (combining full-field k-microscopy with time-of-flight parallel energy recording) and the high brilliance of the soft X-rays used. A direct comparison of bulk and surface spectral functions (taken at low photon energies) reveals a time-reversal-invariant surface state in a local bandgap in the (110)-projected bulk band structure...
March 13, 2017: Nature Materials
https://www.readbyqxmd.com/read/28272026/interplay-between-quantum-confinement-and-surface-effects-in-thickness-selective-stability-of-thin-ag-and-eu-films
#12
Xiaojie Liu, Cai-Zhuang Wang
Using first-principles calculations, we show that both face-centered cubic (fcc) Ag (110) ultrathin films and body-centered cubic (bcc) Eu(110) ultrathin films exhibit height selective stability. However, the origin of such height selection is different. While the height selective stability in fcc Ag(110) films is mainly due to the well-known quantum well states (QWS) ascribed to the quantum confinement effects in free-electron-like metal films, the height selection in bcc Eu(110) film is more complex and also strongly correlated with the occupation of the surface and surface resonance states...
March 8, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28270072/topical-ingenol-mebutate-a-new-treatment-modality-for-multiple-actinic-keratoses-and-field-cancerization
#13
Kresimir Kostovic, Sandra Jerkovic Gulin, Zrinka Bukvic Mokos, Romana Ceovic
BACKGROUND: Ingenol mebutate gel is a recent stirring weapon recommended for the treatment of multiple actinic keratoses (AKs) and field cancerization. This review brings a summary of recent data on the treatment of AKs with ingenol mebutate (IM) providing critical commentary with regard to drug's characteristics, drug's safety profile, treatment regimen, treatment outcome, patient compliance, AK recurrence, cost-effectiveness and cost-utility, as well as guidelines for the management of the treatment of AK...
February 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28268917/automated-basal-cell-carcinoma-detection-in-high-definition-optical-coherence-tomography
#14
Annan Li, Jun Cheng, Ai Ping Yow, Ruchir Srivastava, Damon Wing Kee Wong, Hong Liang Tey, Jiang Liu
Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer. Conventional diagnosis of BCC requires invasive biopsies. Recently, a high-definition optical coherence tomography (HD-OCT) technique has been developed, which provides a non-invasive in vivo imaging method of skin. Good agreements of BCC features between HD-OCT images and histopathological architecture have been found. Therefore it is possible to automatically detect BCC using HD-OCT. This paper presents a novel BCC detection method that consists of four steps: graph based skin surface segmentation, surface flattening, deep feature extraction and the BCC classification...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263978/differing-tumor-suppressor-functions-of-arf-and-p53-in-murine-basal-cell-carcinoma-initiation-and-progression
#15
G Y Wang, C N Wood, J A Dolorito, E Libove, E H Epstein
Human basal cell carcinomas (BCCs) very frequently carry p53 mutations, and p53 loss markedly accelerates murine BCC carcinogenesis. We report here our studies of the mechanism by which p53 is activated to suppress BCC carcinogenesis. We find that aberrant hedgehog signaling in microscopic BCCs activates p53 in part via Arf (that is, the oncogene-induced stress pathway) but not via the DNA damage response pathway. However, Arf loss and p53 loss produce differing outcomes-loss of p53 promotes both tumor initiation and progression; loss of Arf promotes tumor progression but not initiation...
March 6, 2017: Oncogene
https://www.readbyqxmd.com/read/28263022/the-importance-of-patient-centred-care-to-overcome-barriers-in-the-management-of-actinic-keratosis
#16
REVIEW
R Cerio
Visible actinic keratosis (AK) lesions and subclinical (non-visible) sun damage in the field of cancerization are associated with risk of both non-melanoma skin cancer, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), and, more rarely, melanoma. As the incidences of AK and skin cancer are increasing, effective prevention and treatment of AK is essential to minimize disease burden and improve patient quality of life. Currently, AK lesions are often left untreated and field therapies are underused...
March 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28262683/thermodynamics-and-equations-of-state-of-iron-to-350%C3%A2-gpa-and-6000%C3%A2-k
#17
P I Dorogokupets, A M Dymshits, K D Litasov, T S Sokolova
The equations of state for solid (with bcc, fcc, and hcp structures) and liquid phases of Fe were defined via simultaneous optimization of the heat capacity, bulk moduli, thermal expansion, and volume at room and higher temperatures. The calculated triple points at the phase diagram have the following parameters: bcc-fcc-hcp is located at 7.3 GPa and 820 K, bcc-fcc-liquid at 5.2 GPa and 1998 K, and fcc-hcp-liquid at 106.5 GPa and 3787 K. At conditions near the fcc-hcp-liquid triple point, the Clapeyron slope of the fcc-liquid curve is dT/dP = 12...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28260938/superficial-basal-cell-carcinoma-treated-with-70-trichloroacetic-acid-applied-topically-a-case-study
#18
Anca Chiriac, Piotr Brzezinski, Cosmin Moldovan, Cristian Podoleanu, Marius Florin Coros, Simona Stolnicu
BACKGROUND: Basal cell carcinoma (BCC) is the most common form of skin cancer, affecting millions of people worldwide. The treatment concept for BCCs is the surgical one, but it is costly, as such, searching for alternative medical therapeutics is justified. AIM: To highlight the efficacy of high concentration (70%) trichloroacetic acid (TCA) as a choice therapy for low-risk BCC. METHOD AND PATIENT: Authors present, for the first time, the use of a high concentration TCA applied once a week for 2 consecutive weeks with a toothpick, on a patient with BCC on the right preauricular area...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28259916/notch-signaling-is-significantly-suppressed-in-basal-cell-carcinomas-and-activation-induces-basal-cell-carcinoma-cell-apoptosis
#19
Feng-Tao Shi, Mei Yu, David Zloty, Robert H Bell, Eddy Wang, Noushin Akhoundsadegh, Gigi Leung, Anne Haegert, Nicholas Carr, Jerry Shapiro, Kevin J McElwee
A subset of basal cell carcinomas (BCCs) are directly derived from hair follicles (HFs). In some respects, HFs can be defined as 'ordered' skin appendage growths, while BCCs can be regarded as 'disordered' skin appendage growths. The aim of the present study was to examine HFs and BCCs to define the expression of common and unique signaling pathways in each skin appendage. Human nodular BCCs, along with HFs and non‑follicular skin epithelium from normal individuals, were examined using microarrays, qPCR, and immunohistochemistry...
February 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28259105/association-between-programmed-death-ligand-1-expression-in-patients-with-basal-cell-carcinomas-and-the-number-of-treatment-modalities
#20
Julia Chang, Gefei A Zhu, Christine Cheung, Shufeng Li, Jinah Kim, Anne Lynn S Chang
Importance: Response to programmed death 1 (PD-1) inhibitors has been associated with programmed death ligand 1 (PD-L1) expression levels in several cancers, but PD-L1 expression and its clinical significance in basal cell carcinoma (BCC) are unknown to date. Objective: To assess PD-L1 expression in treatment-naive and treated BCCs. Design, Setting, and Participants: This investigation was a cross-sectional study at a single academic tertiary referral center...
March 4, 2017: JAMA Dermatology
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