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https://www.readbyqxmd.com/read/28917298/high-prevalence-of-bovine-cysticercosis-found-during-evaluation-of-different-post-mortem-detection-techniques-in-belgian-slaughterhouses
#1
Famke Jansen, Pierre Dorny, Dirk Berkvens, Anke Van Hul, Nick Van den Broeck, Caroline Makay, Nicolas Praet, Ramon Marc Eichenberger, Peter Deplazes, Sarah Gabriël
Bovine cysticercosis (BCC), caused by the helminth Taenia saginata, is currently diagnosed solely by official meat inspection (MI) based on macroscopic detection of viable cysticerci or typical lesions of degenerated larvae. MI has a known low sensitivity (<16%), leading to a large proportion of infected cattle carcasses entering the human food chain and posing a risk to public health. Prevalence in Belgium based on MI results is estimated at around 0.22%. Due to the low sensitivity of MI, alternative techniques to detect BCC should be considered...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28913301/concordant-surgical-treatment-non-melanocytic-skin-cancer-of-the-head-and-neck
#2
Wan Cheol Ryu, In Chang Koh, Yong Hae Lee, Jong Hyun Cha, Sang Il Kim, Chang Gyun Kim
BACKGROUND: Skin cancer is the most common type of cancer. Of the 4 million skin lesions excised annually worldwide, approximately 2 million are considered cancerous. In this study, we aimed to describe a regional experience with skin cancers treated by a single senior surgeon and to provide a treatment algorithm. METHODS: The medical records of 176 patients with head and neck non-melanocytic skin cancer (NMSC) who were treated by a single surgeon at our institution between January 2010 and May 2016 were retrospectively reviewed, and their data (age, sex, pathological type, tumor location/size, treatment modality) were analyzed...
March 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28910350/phylogeographic-genomic-and-meropenem-susceptibility-analysis-of-burkholderia-ubonensis
#3
Erin P Price, Derek S Sarovich, Jessica R Webb, Carina M Hall, Sierra A Jaramillo, Jason W Sahl, Mirjam Kaestli, Mark Mayo, Glenda Harrington, Anthony L Baker, Lindsay C Sidak-Loftis, Erik W Settles, Madeline Lummis, James M Schupp, John D Gillece, Apichai Tuanyok, Jeffrey Warner, Joseph D Busch, Paul Keim, Bart J Currie, David M Wagner
The bacterium Burkholderia ubonensis is commonly co-isolated from environmental specimens harbouring the melioidosis pathogen, Burkholderia pseudomallei. B. ubonensis has been reported in northern Australia and Thailand but not North America, suggesting similar geographic distribution to B. pseudomallei. Unlike most other Burkholderia cepacia complex (Bcc) species, B. ubonensis is considered non-pathogenic, although its virulence potential has not been tested. Antibiotic resistance in B. ubonensis, particularly towards drugs used to treat the most severe B...
September 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28899373/maximizing-the-impact-of-malaria-funding-through-allocative-efficiency-using-the-right-interventions-in-the-right-locations
#4
Nick Scott, S Azfar Hussain, Rowan Martin-Hughes, Freya J I Fowkes, Cliff C Kerr, Ruth Pearson, David J Kedziora, Madhura Killedar, Robyn M Stuart, David P Wilson
BACKGROUND: The high burden of malaria and limited funding means there is a necessity to maximize the allocative efficiency of malaria control programmes. Quantitative tools are urgently needed to guide budget allocation decisions. METHODS: A geospatial epidemic model was coupled with costing data and an optimization algorithm to estimate the optimal allocation of budgeted and projected funds across all malaria intervention approaches. Interventions included long-lasting insecticide-treated nets (LLINs), indoor residual spraying (IRS), intermittent presumptive treatment during pregnancy (IPTp), seasonal mass chemoprevention in children (SMC), larval source management (LSM), mass drug administration (MDA), and behavioural change communication (BCC)...
September 12, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28898461/risks-of-different-skin-tumor-combinations-after-a-first-melanoma-squamous-cell-carcinoma-and-basal-cell-carcinoma-in-dutch-population-based-cohorts-1989-2009
#5
R J T van der Leest, L M Hollestein, L Liu, T Nijsten, E de Vries
BACKGROUND: Skin cancer patients are primarily at increased risk of developing subsequent skin cancers of the same type. Shared risk factors might also increase the occurrence of a different type of subsequent skin cancer. OBJECTIVE: To investigate risks of different skin tumor combinations after a first melanoma, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). METHODS: All melanoma and SCC patients included in the national Netherlands Cancer Registry (NCR) and all BCC patients included in the regional Eindhoven Cancer Registry (ECR) between 1989 and 2009 were followed until diagnosis of a subsequent different skin cancer (melanoma, SCC or BCC), date of death or end of study...
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28894745/monitoring-intervention-fidelity-of-a-lifestyle-behavioral-intervention-delivered-through-telehealth
#6
Ashley Sineath, Lauren Lambert, Catherine Verga, Miranda Wagstaff, Brooks C Wingo
BACKGROUND: Technology-based lifestyle behavioral interventions (i.e., telehealth, mHealth, eHealth, and/or digital health) are becoming an alternative standard of care and possess several advantages over traditional clinical settings such as convenience, cost, and the ability to tailor plans and feedback to a participant's individual needs. These technology-based interventions also present unique challenges to intervention fidelity due to extra elements involved in executing the intervention...
2017: MHealth
https://www.readbyqxmd.com/read/28894712/evaluation-of-the-level-of-zinc-and-malondialdehyde-in-basal-cell-carcinoma
#7
Ziba Majidi, Mahmoud Djalali, Mohammad Hasan Javanbakht, Mojtaba Fathi, Mahnaz Zarei, Koorosh Foladsaz
BACKGROUND: Basal Cell Carcinoma (BCC) is one of the most common skin cancers in the world and that use to lifestyle, increasing chemical pollutions, environmental factors and poor nutrition. The most important cause of this cancer is oxidative stress and free radicals so antioxidant activities for the body are so important. The aim of this study was to determine the variation of zinc and (Malondialdehyde) MDA in BCC patients. METHODS: This study has been performed on case and control patients from 2013 to 2014...
August 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28887802/small-molecule-inhibitors-of-the-hedgehog-pathway-in-the-treatment-of-basal-cell-carcinoma-of-the-skin
#8
REVIEW
Rebecca Danhof, Karl Lewis, Mariah Brown
Basal cell carcinoma (BCC) is the most common type of skin cancer, with rising incidence rates primarily attributed to an aging population and ultraviolet radiation exposure. While the majority of BCCs are localized and respond to standard therapies, a very small minority of these tumors become locally destructive or metastasize. These advanced BCCs may not be amenable to localized treatment with surgery and/or radiation therapy. Most BCCs result from mutations in key receptors in the Hedgehog (HH) signaling pathway...
September 8, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28886209/treatment-of-superficial-basal-cell-carcinoma-by-topical-photodynamic-therapy-with-fractionated-5-aminolevulinic-acid-20-versus-two-stage-topical-methylaminolevulinic-acid-results-of-a-randomized-controlled-trial
#9
J P H M Kessels, H Kreukels, P J Nelemans, M H Roozeboom, H van Pelt, K Mosterd, E R M de Haas, N W J Kelleners-Smeets
BACKGROUND: Basal cell carcinoma (BCC) is the most common type of skin cancer with growing incidence rates. Photodynamic therapy (PDT) is a frequently used treatment, especially for superficial BCC (sBCC). Two topical photosensitizing agents are currently used to treat sBCC: 5-aminolevulinic acid (ALA) and its methyl-ester (MAL). Previous research showed a high efficacy of ALA-PDT using a 2-fold fractionated illumination scheme in which two light fractions of 20 and 80 J/cm2 are delivered, four and six hours after ALA application...
September 8, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28884244/lasers-and-intense-pulsed-light-ipl-association-with-cancerous-lesions
#10
Caerwyn Ash, Godfrey Town, Rebecca Whittall, Louise Tooze, Jaymie Phillips
The development and use of light and lasers for medical and cosmetic procedures has increased exponentially over the past decade. This review article focuses on the incidence of reported cases of skin cancer post laser or IPL treatment. The existing evidence base of over 25 years of laser and IPL use to date has not raised any concerns regarding its long-term safety with only a few anecdotal cases of melanoma post treatment over two decades of use; therefore, there is no evidence to suggest that there is a credible cancer risk...
September 7, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28881857/genetic-association-between-tnf-%C3%AE-promoter-polymorphism-and-susceptibility-to-squamous-cell-carcinoma-basal-cell-carcinoma-and-melanoma-a-meta-analysis
#11
REVIEW
Ning Liu, Guang-Jing Liu, Juan Liu
Tumor necrosis factor-alpha (TNF-α) is a multifunctional pro-inflammatory cytokine that plays an important role in cancer development. We performed a meta-analysis to assess the relationship between single nucleotide polymorphisms in the TNF-α promoter region (rs1800629 and rs361525) and susceptibility to squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and melanoma. After database retrieval, article selection, data extraction, and quality assessment, 20 articles comprising 4865 cases and 6329 controls were included in this study...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28874239/-atypical-subcutaneous-presentation-of-a-basal-cell-carcinoma
#12
Sine Holst-Albrechtsen, Jacob Juel, Anne Lene H Wagenblast
Basal cell carcinoma (BCC) have many treatment options either by dermatologist, with excision or radiotherapy. A 78-year-old woman had a BCC removed surgically, and 18 years after she had a subcutaneously located tumour extirpated at the same location. The result of pathological examination was BCC located atypically in the subcutis. Iatrogenic seeding from primary excision or non-radical primary excision may explain this presentation. This is only the second report of subcutaneously located BCC.
August 28, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28872056/new-understanding-of-nano-scale-interstitial-dislocation-loops-in-bcc-iron
#13
Ning Gao, Jiachao Chen, Richard J Kurtz, Zhiguang Wang, R F Zhang, Fei Gao
Complex states of nanoscale interstitial dislocation loop can be described by its habit plane and Burgers vector. Using atomistic simulations, we provide direct evidences on the change of the habit plane of a ½<111> loop from {111} to {110} and {211}, in agreement with TEM observations. A new {100} habit plane of this loop is also predicted by simulations. The non-conservation of the Burgers vector is approved theoretically for: (1) dislocation reactions between loops with different Burgers vectors and (2) the transition between <100> loops and ½<111> loops...
September 5, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28869610/mutations-in-actrt1-and-its-enhancer-rna-elements-lead-to-aberrant-activation-of-hedgehog-signaling-in-inherited-and-sporadic-basal-cell-carcinomas
#14
Elodie Bal, Hyun-Sook Park, Zakia Belaid-Choucair, Hülya Kayserili, Magali Naville, Marine Madrange, Elena Chiticariu, Smail Hadj-Rabia, Nicolas Cagnard, Francois Kuonen, Daniel Bachmann, Marcel Huber, Cindy Le Gall, Francine Côté, Sylvain Hanein, Rasim Özgür Rosti, Ayca Dilruba Aslanger, Quinten Waisfisz, Christine Bodemer, Olivier Hermine, Fanny Morice-Picard, Bruno Labeille, Frédéric Caux, Juliette Mazereeuw-Hautier, Nicole Philip, Nicolas Levy, Alain Taieb, Marie-Françoise Avril, Denis J Headon, Gabor Gyapay, Thierry Magnaldo, Sylvie Fraitag, Hugues Roest Crollius, Pierre Vabres, Daniel Hohl, Arnold Munnich, Asma Smahi
Basal cell carcinoma (BCC), the most common human cancer, results from aberrant activation of the Hedgehog signaling pathway. Although most cases of BCC are sporadic, some forms are inherited, such as Bazex-Dupré-Christol syndrome (BDCS)-a cancer-prone genodermatosis with an X-linked, dominant inheritance pattern. We have identified mutations in the ACTRT1 gene, which encodes actin-related protein T1 (ARP-T1), in two of the six families with BDCS that were examined in this study. High-throughput sequencing in the four remaining families identified germline mutations in noncoding sequences surrounding ACTRT1...
September 4, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28869585/brca1-regulation-on-%C3%AE-hcg-a-mechanism-for-tumorigenicity-in-brca1-defective-breast-cancer
#15
S K Sengodan, R Nadhan, R S Nair, S K Hemalatha, V Somasundaram, R R Sushama, A Rajan, N R Latha, G R Varghese, R K Thankappan, J M Kumar, A Chil, T V Anilkumar, P Srinivas
Human chorionic gonadotropin β (β-hCG) has been implicated in breast tumorigenesis. However, the role of this hormone is highly controversial as certain studies suggest it has anti-tumor properties while others have found it to be pro-tumorigenic. To unveil the truth, we have analyzed the expression of β-hCG in breast cancer. We identified for the first time that β-hCG expression is linked to BRCA1 status and its overexpression is seen in BRCA1 mutated breast cancer cells, BRCA1 conditional knockout mouse breast cancer tissues and BRCA1 floxed basal cell carcinoma (BCC) tissues...
September 4, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28868340/e-selectin-and-sdf-1-regulate-metastatic-trafficking-of-breast-cancer-cells-within-the-bone
#16
Trevor T Price, Dorothy A Sipkins
E-selectin is a key mediator of breast cancer cell (BCC) metastatic entry into the bone and stromal-derived factor 1 (SDF-1) is a critical molecular anchor for BCCs within discrete pro-dormancy bone marrow (BM) niches. Small-molecule inhibitors blocked metastatic entry and mobilized established disease from BM, suggesting a new treatment strategy to prevent breast cancer relapse.
2017: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/28867871/mapping-regional-risks-from-climate-change-for-rainfed-rice-cultivation-in-india
#17
Kuntal Singh, Colin J McClean, Patrick Büker, Sue E Hartley, Jane K Hill
Global warming is predicted to increase in the future, with detrimental consequences for rainfed crops that are dependent on natural rainfall (i.e. non-irrigated). Given that many crops grown under rainfed conditions support the livelihoods of low-income farmers, it is important to highlight the vulnerability of rainfed areas to climate change in order to anticipate potential risks to food security. In this paper, we focus on India, where ~ 50% of rice is grown under rainfed conditions, and we employ statistical models (climate envelope models (CEMs) and boosted regression trees (BRTs)) to map changes in climate suitability for rainfed rice cultivation at a regional level (~ 18 × 18 km cell resolution) under projected future (2050) climate change (IPCC RCPs 2...
September 2017: Agricultural Systems
https://www.readbyqxmd.com/read/28862213/profile-of-eyelid-malignancy-in-a-tertiary-health-care-center-in-north-india
#18
Priyanka Gupta, Ramesh Chandra Gupta, Lubna Khan
CONTEXT: The eyelids are affected by wide spectrum of benign and malignant lesions. Basal cell carcinoma (BCC) is the most common malignancy encountered while other malignant lesions such as sebaceous cell carcinoma and squamous cell carcinoma are rare. Data regarding geographical variation in trends of malignant eyelid tumors are presented in the current study. SETTINGS AND DESIGN: Prospective, longitudinal, observational study was conducted from December 2011 to October 2013...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28862133/treatment-patterns-and-outcomes-for-patients-with-locally-advanced-basal-cell-carcinoma-before-availability-of-hedgehog-pathway-inhibitors-a-retrospective-chart-review
#19
John T Lear, Nicole Basset-Seguin, Martin Kaatz, Thomas Jouary, Laurent Mortier, Tommaso Fabrizio, Robert Herd, Martin Leverkus, Cedric Revil, Damian R Page, Jean-Jacques Grob
Understanding the molecular basis of basal cell carcinoma (BCC) has led to development of Hedgehog pathway inhibitors (HPIs) for patients with advanced forms of BCC (aBCC). A practical definition of aBCC as a distinct disease entity is unavailable, and epidemiological information is limited. To conduct the RONNIE study to describe characteristics, treatment patterns, and outcomes of patients with aBCC during the period preceding HPI introduction, as well as results from patients with locally advanced BCC (laBCC)...
August 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28859735/molecular-variations-in-histologic-subtypes-of-basal-cell-carcinoma
#20
REVIEW
Min Deng, Amanda F Marsch, Vesna Petronic-Rosic
There are many molecular variations in the histologic subtypes of basal cell carcinoma (BCC); Ki67 and Bcl-2 expression differs among them and might relate to their prognostic features. The clinically notable friability and its histologic counterpart, retraction, are dependent on cell-cell adhesion and basement membrane characteristics, which may be altered in different ways depending on the tumor morphology and phenotype. Finally, we discuss the pathogenesis of BCCs and recent molecular advances with a review of new and upcoming molecular-based therapeutics...
2017: Skinmed
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