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https://www.readbyqxmd.com/read/29790600/characterizing-the-tissue-dielectric-constant-of-skin-basal-cell-cancer-lesions
#1
H N Mayrovitz, S R Gildenberg, P Spagna, L Killpack, D A Altman
BACKGROUND: Measuring tissue dielectric constant (TDC) of cancer tissues to distinguish them from normal or non-cancerous tissues has been an active area of research that has targeted several different cancer types usually using in vitro specimens. The goal of this study was to determine if and to what extent TDC values measured in vivo at 300 MHz using a simple hand-held measuring device might differentiate between skin cancer lesions and non-cancerous skin. MATERIALS AND METHODS: Triplicate TDC measurements were made in 32 patients who were subsequently diagnosed with skin basal cell carcinoma (BCC) and in 14 patients subsequently diagnosed as having non-cancerous lesions...
May 23, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29789760/high-dose-rate-brachytherapy-in-treatment-of-non-melanoma-skin-cancer-of-head-and-neck-region-preliminary-results-of-a-prospective-single-institution-study
#2
Bita Kalaghchi, Ebrahim Esmati, Reza Ghalehtaki, Marzieh Gomar, Ramin Jaberi, Soraya Gholami, Somayyeh Babaloui, Mansoureh Nabavi, Sarvazad Sotoudeh, Nezhat Khanjani, Ali Kazemian, Farnaz Amouzegar-Hashemi, Mahdi Aghili, Marzieh Lashkari
Purpose: Skin cancers are the most common human malignancy with increasing incidence. Currently, surgery is standard of care treatment for non-melanoma skin cancers. However, brachytherapy is a growing modality in the management of skin cancers. Therefore, we aimed to assess the outcome of patients with non-melanoma skin cancers treated by high-dose-rate (HDR) brachytherapy with surface mold technique. Material and methods: In this prospective study, we recruited patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin who were candidates for definitive or adjuvant brachytherapy during 2013-2014...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29785435/assessing-the-performance-of-mm-pbsa-and-mm-gbsa-methods-7-entropy-effects-on-the-performance-of-end-point-binding-free-energy-calculation-approaches
#3
Huiyong Sun, Lili Duan, Fu Chen, Hui Liu, Zhe Wang, Peichen Pan, Feng Zhu, John Z H Zhang, Tingjun Hou
Entropy effects play an important role in drug-target interactions, but the entropic contribution to ligand-binding affinity is often neglected by end-point binding free energy calculation methods, such as MM/GBSA and MM/PBSA, due to the expensive computational cost of normal mode analysis (NMA). Here, we systematically investigated entropy effects on the prediction power of MM/GBSA and MM/PBSA using >1500 protein-ligand systems and six representative AMBER force fields. Two computationally efficient methods, including NMA based on truncated structures and the interaction entropy approach, were used to estimate the entropic contributions to ligand-target binding free energies...
May 22, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29785331/nodular-basal-cell-carcinoma-of-the-face-successfully-treated-with-ingenol-mebutate-0-015-gel
#4
Silvia S Iannazzone, Vito Ingordo
Surgical excision is the first-choice treatment for basal cell carcinoma (BCC). Other treatments with topical agents such as 5-fluorouracil or imiquimod have also been suggested for use in superficial BCC (sBCC). Ingenol mebutate (IM) is a novel agent employed in the treatment of superficial actinic keratoses. The drug has been also successfully used in the treatment of sBCC. A case of large nodular BCC (nBCC) of the face in a 100-year-old inoperable woman is described. IM 0.015% gel was applied once daily for three consecutive days...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29784883/cytochrome-bd-oxidase-has-an-important-role-in-sustaining-growth-and-development-of-streptomyces-coelicolor-a3-2-under-oxygen-limiting-conditions
#5
Marco Fischer, Dörte Falke, Carolin Naujoks, R Gary Sawers
Streptomyces coelicolor A3 (2) is a filamentously growing, spore-forming, obligately aerobic actinobacterium that uses both a copper- aa3 - type cytochrome c oxidase and a cytochrome bd oxidase to respire oxygen. Using defined knock-out mutants we demonstrated that either of these terminal oxidases was capable of allowing the bacterium to grow and complete its developmental cycle. The genes encoding the bcc complex and the aa3 oxidase are clustered at a single locus. Using western blot analyses we showed that the bcc-aa3 oxidase branch is more prevalent than the bd oxidase in spores...
May 21, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29781264/bcc-and-vismodegib-can-we-treat-and-remould-at-the-same-time
#6
Filomena Russo, Virginia Mancini, Emanuele Trovato, Michele Fimiani, Paolo Taddeucci
No abstract text is available yet for this article.
May 16, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29776351/a-computational-study-of-hedgehog-signalling-involved-in-basal-cell-carcinoma-reveals-the-potential-and-limitation-of-combination-therapy
#7
Antoine Buetti-Dinh, Rebecca Jensen, Ran Friedman
BACKGROUND: The smoothened (SMO) receptor is an essential component of the Sonic hedgehog (SHH) signalling, which is associated with the development of skin basal cell carcinoma (BCC). SMO inhibitors are indicated for BCC patients when surgical treatment or radiation therapy are not possible. Unfortunately, SMO inhibitors are not always well tolerated due to severe side effects, and their therapeutical success is limited by resistance mutations. METHODS: We investigated how common are resistance-causing mutations in two genomic databases which are not linked to BCC or other cancers, namely 1000 Genomes and ExAC...
May 18, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29775390/polarization-and-distribution-of-tumor-associated-macrophages-and-cox-2-expression-in-basal-cell-carcinoma-of-the-ocular-adnexae
#8
Ute Kaiser, Karin U Loeffler, Jennifer Nadal, Frank G Holz, Martina C Herwig-Carl
PURPOSE: Basal cell carcinoma (BCC) is a locally invasive skin tumor which can be subdivided into a circumscribed nodular and an invasive fibrosing subtype. There is increasing evidence that macrophages play an important role in interacting between tumor cells and their microenvironment, thereby affecting not only the invasive potential but also the patients' prognosis. Thus, we wanted to compare these two BCC variants with regard to tumor-related inflammation, COX-2 expression, distribution and polarization of tumor-associated macrophages...
May 18, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29775328/phonon-softening-due-to-melting-of-the-ferromagnetic-order-in-elemental-iron
#9
Qiang Han, Turan Birol, Kristjan Haule
We study the fundamental question of the lattice dynamics of a metallic ferromagnet in the regime where the static long-range magnetic order is replaced by the fluctuating local moments embedded in a metallic host. We use the ab initio density functional theory + embedded dynamical mean-field theory functional approach to address the dynamic stability of iron polymorphs and the phonon softening with an increased temperature. We show that the nonharmonic and inhomogeneous phonon softening measured in iron is a result of the melting of the long-range ferromagnetic order and is unrelated to the first-order structural transition from the bcc to the fcc phase, as is usually assumed...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29770401/anharmonic-lattice-dynamics-of-bcc-sodium-under-high-pressures
#10
Shasha Li, Chen Wang, Yue Chen
Phonon-phonon coupling in body centered cubic (bcc) sodium is studied from first-principles to investigate its anharmonic lattice dynamics under high pressures. The renormalization of the phonon frequencies of the transverse acoustic (TA) modes along the Γ-N direction is found to be distinctly different compared with other phonon modes. We find that these TA modes firstly stiffen with increasing external pressure below 30 GPa; however, at higher pressures, these TA modes exhibit a nonmonotonic behavior and soften unexpectedly...
May 17, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29769596/hcp-fcc-nucleation-in-bcc-iron-under-different-anisotropic-compressions-at-high-strain-rate-molecular-dynamics-study
#11
Jian-Li Shao, Pei Wang, Feng-Guo Zhang, An-Min He
Previous researches have revealed the importance of shear and the orientation dependence in the structural transition of iron. In this work, we introduce a series of shear deformations by adjusting the strain ratio between the longitudinal ([001]) and transversal ([010] and [100]) directions, and then investigate this structural transition under different anisotropic compressions with molecular dynamics simulations. It is found that the shear deformation can lower the transition pressure notably, and even change the nucleation structure and morphology...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29766626/co-2-laser-and-photodynamic-therapy-study-of-efficacy-in-periocular-bcc
#12
Santo Raffaele Mercuri, Pina Brianti, Annunziata Dattola, Luigi Bennardo, Martina Silvestri, Giusy Schipani, Steven Paul Nisticò
Basal cell carcinoma (BCC), the most common type of skin cancer in the world, usually arises in sun-exposed areas of the skin. The therapeutic approach to periocular BCC has changed in the last few years. Currently the treatment, considering the delicate localization of the disease, must not only ensure complete recovery from the neoplastic disease, but must also satisfy functional and aesthetic criteria. In this study we tried to evaluate the efficacy of CO2 laser and photodynamic therapy in periocular BCC...
May 15, 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29765947/leser-tr%C3%A3-lat-syndrome-in-a-male-with-breast-carcinoma-and-eyelid-basal-cell-carcinoma
#13
Rajiv Garg, Siddharth Madan, Pragya Prakash, Ram Chander, Monisha Choudhary
Purpose: Leser-Trélat syndrome consists of appearance of a solid tumor-like carcinoma breast, colon, or stomach following eruption of multiple seborrheic keratoses (SK) of the skin. We present an unusual and possibly the first case report of Leser-Trélat syndrome in a male patient with a history of mastectomy for breast carcinoma who presented to us with a second malignancy in the form of basal cell carcinoma (BCC) of the lower eyelid. Procedure: A 75-year-old male presented in 2014 with a history of modified radical mastectomy for infiltrating ductal carcinoma of the left breast which was performed 11 years prior to the day of presentation...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29764277/human-papillomavirus-hpv-is-absent-in-branchial-cleft-cysts-of-the-neck-distinguishing-them-from-hpv-positive-cystic-metastasis
#14
Lars Sivars, David Landin, Marzia Rizzo, Linnea Haeggblom, Cinzia Bersani, Eva Munck-Wikland, Anders Näsman, Tina Dalianis, Linda Marklund
BACKGROUND: Distinguishing branchial cleft cysts (BCCs) from cystic metastases of a human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (OPSCC) is challenging. Fine needle aspirates (FNAs) from cystic metastasis may be non-representative, while reactive squamous cells from BCC can be atypic. Based on cytology and with the support of HPV DNA positivity many centers treat cystic metastasis oncological and thus patients are spared neck dissection. To do so safely, one must investigate whether HPV DNA and p16INK4a overexpression is found exclusively in cystic metastases and not in BCC...
May 15, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29758902/organic-carbon-source-and-salinity-shape-sediment-bacterial-composition-in-two-china-marginal-seas-and-their-major-tributaries
#15
Kai Wang, Li Zou, Xinxin Lu, Xiaozhen Mou
Marginal sea sediments receive organic substrates of different origins, but whether and to what extent sediment microbial communities are reflective of the different sources of organic substrates remain unclear. To address these questions, sediment samples were collected in two connected China marginal seas, i.e., Bohai Sea and Yellow Sea, and their two major tributaries (Yellow River and Liao River). Sediment bacterial community composition (BCC) was examined using 16S rRNA gene pyrosequencing. In addition, physicochemical variables that describe environmental conditions and sediment features were measured...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29758751/fcc-bcc-phase-transition-in-plasma-crystals-using-time-resolved-measurements
#16
C Dietz, R Bergert, B Steinmüller, M Kretschmer, S Mitic, M H Thoma
Three-dimensional plasma crystals are often described as Yukawa systems for which a phase transition between the crystal structures fcc and bcc has been predicted. However, experimental investigations of this transition are missing. We use a fast scanning video camera to record the crystallization process of 70 000 microparticles and investigate the existence of the fcc-bcc phase transition at neutral gas pressures of 30, 40, and 50 Pa. To analyze the crystal, robust phase diagrams with the help of a machine learning algorithm are calculated...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29758283/tgf-%C3%AE-fibronectin-and-integrin-%C3%AE-5%C3%AE-1-promote-invasion-in-basal-cell-carcinoma
#17
François Kuonen, Isabelle Surbeck, Kavita Y Sarin, Monique Dontenwill, Curzio Ruegg, Michel Gilliet, Anthony E Oro, Olivier Gaide
Basal cell carcinoma (BCC) is the most frequent human cancer and is becoming an important health problem in an ageing population. Based on their clinical and histological characteristics, thick BCC are typically divided into low-risk nodular and high-risk infiltrative subtypes, although the underlying mechanisms are poorly understood. We have identified molecular mechanisms that explain the aggressiveness of high-risk infiltrative BCC, with a potential direct clinical impact. In this study, we first show that fibroblasts, TGFβ and fibronectin are found preferentially in infiltrative human BCC...
May 11, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29752702/daylight-photodynamic-therapy-for-actinic-keratoses
#18
REVIEW
Colin A Morton, Lasse R Braathen
Topical photodynamic therapy (PDT) using daylight is effective in the treatment of actinic keratoses (AKs), offering the potential for treatment of large fields such as full face and balding scalp, but with minimal therapy-associated pain. Comparison with conventional PDT indicates similar efficacy for thin and moderate-thickness AKs, but with significantly less discomfort/pain, driving a patient preference for daylight-mediated PDT (DL-PDT) compared with conventional PDT using high-intensity office/hospital-based light sources...
May 11, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29749962/effects-of-temperature-and-void-on-the-dynamics-and-microstructure-of-structural-transition-in-single-crystal-iron
#19
Jian-Li Shao, Pei Wang, Feng-Guo Zhang, An-Min He
With classic molecular dynamics simulations, we investigate the effects of temperature and void on the bcc to hcp/fcc structural transition in single crystal iron driven by 1D ([001]) and 3D (uniform) compressions. The results show that the pressure threshold does not reduce monotonously with temperature. The pressure threshold firstly increases and then decreases in the range of 60-360 K under 1D compression, while the variation trend is just opposite under 3D compression. As expected, the initial defect may lower the pressure threshold via heterogenous nucleation...
May 11, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29746427/risk-factors-for-basal-cell-carcinoma-in-men-younger-than-40-years-a-case-control-study
#20
Kathleen M Nemer, Tyler M Bauman, Alan S Boyd
BACKGROUND: Basal cell carcinoma (BCC) is the most common malignancy in the United States and is more prevalent in older populations. OBJECTIVE: The aim of this study was to investigate BCC risk factors in male patients younger than 40 years. MATERIALS AND METHODS: A consecutive series of male patients with pathology-proven BCC and younger than 40 years at time of diagnosis were retrospectively identified along with matched controls. Phone interviews were conducted using a structured questionnaire, and differences between patients with and without BCC were investigated...
May 9, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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