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https://www.readbyqxmd.com/read/27920679/basal-cell-carcinoma-on-the-sole-an-easily-missed-cancer
#1
Natalie L Hone, Radhika Grandhi, Adam A Ingraffea
Basal cell carcinoma (BCC) is the most common skin cancer, and solar ultraviolet ray exposure is the most significant risk factor for its development. The plantar foot is infrequently exposed to the sun, thus the presence of BCC on the sole is rare. We report a case of BCC on the sole of the foot and its treatment in the hope to facilitate its detection.
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/27908679/skin-surface-brachytherapy-a-survey-of-contemporary-practice-patterns
#2
Anna O Likhacheva, Phillip M Devlin, Shervin M Shirvani, Christopher A Barker, Phillip Beron, Ajay Bhatnagar, Stephen W Doggett, Lawrence Hochman, Charles Hsu, Michael Kasper, Martin Keisch, Subhakar Mutyala, Bradley Prestidge, Silvia Rodriguez Villalba, Vershalee Shukla, Srinath Sundararaman, Mitchell Kamrava
PURPOSE: The aim of this study was to define current patterns of care among radiation oncologists who use skin surface brachytherapy for the treatment of cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) in academic and community settings. METHODS AND MATERIALS: A 30-question electronic survey was administered to clinician members of the American Brachytherapy Society. The respondents were asked to provide details regarding their clinical practice and their approach to skin surface brachytherapy...
November 28, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27906855/periocular-basal-cell-carcinoma-predictors-for-recurrence-and-infiltration-of-the-orbit
#3
Alena Furdova, Pavol Lukacko
PURPOSE: To present the proportion of patients with periocular basal cell carcinoma (BCC) who underwent orbital exenteration and to evaluate the significance of the risk factors. DESIGN: Retrospective, comparative, interventional case series. METHODS: Data of all patients with BCC between 2008 and 2014 were reviewed for patient demographics, previous treatment options, tumor localization, and histopathologic subtype. RESULTS: In group of 256 patients, orbital exenteration underwent 7 patients (2...
November 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27905158/metastatic-spinal-cord-compression-from-basal-cell-carcinoma-of-the-skin-treated-with-surgical-decompression-and-vismodegib-case-report-and-review-of-hedgehog-signalling-pathway-inhibition-in-advanced-basal-cell-carcinoma
#4
J McGrane, S Carswell, T Talbot
We report a case of a 66-year-old man with locally advanced and metastatic basal cell carcinoma (BCC) causing spinal cord compression, which was treated with spinal surgery and subsequent vismodegib. The patient presented with a large fungating chest wall lesion and a metastasis in T8 that was causing cord compression. He had neurosurgical decompression of the T8 lesion and fixation of the spine. Punch biopsy from the fungating chest wall lesion showed a BCC with some malignant squamous differentiation (basosquamous)...
November 30, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27902821/risk-factors-for-basal-cell-carcinoma-among-patients-with-basal-cell-nevus-syndrome-development-of-a-basal-cell-nevus-syndrome-patient-registry
#5
Daniel C Solis, Gina P Kwon, Katherine J Ransohoff, Shufeng Li, Harvind S Chahal, Mina S Ally, Marieke A D Peters, Kristi Schmitt-Burr, Joselyn Lindgren, Irene Bailey-Healy, Joyce M Teng, Ervin H Epstein, Jean Y Tang
Importance: Patients with basal cell nevus syndrome (BCNS) have a greater risk of developing numerous basal cell carcinomas (BCCs). Risk factors influencing the wide variation in tumor burden are poorly understood. Objective: To describe the burden of BCCs in patients with BCNS in the United States and identify potential risk factors for BCCs. Design, Setting, and Participants: Prospective clinical registry with data collected from September 2014 to March 2016...
November 30, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27895902/effect-of-%C3%AE-lactamase-inhibitors-on-in-vitro-activity-of-%C3%AE-lactam-antibiotics-against-burkholderia-cepacia-complex-species
#6
Annelien Everaert, Tom Coenye
BACKGROUND: Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients. Intrinsic resistance to a wide range of antimicrobial agents, including a variety of β-lactam antibiotics, is frequently observed in Bcc strains. Resistance to β-lactams is most commonly mediated by efflux pumps, alterations in penicillin-binding proteins or the expression of β-lactamases. β-lactamase inhibitors are able to restore the in vitro activity of β-lactam molecules against a variety of Gram-negative species, but the effect of these inhibitors on the activity of β-lactam treatment against Bcc species is still poorly investigated...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27892984/anatomical-distributions-of-basal-cell-carcinoma-and-squamous-cell-carcinoma-in-a-population-based-study-in-queensland-australia
#7
Padmini Subramaniam, Catherine M Olsen, Bridie S Thompson, David C Whiteman, Rachel E Neale
Importance: Keratinocyte cancers (KCs), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the most common cancers among fair-skinned populations worldwide. Although studies have indicated that the anatomical distribution of BCC and SCC differ, few have compared them directly in well-defined population samples. Objectives: To describe and compare the anatomical distribution of BCC and SCC in a population-based sample in Queensland, Australia...
November 23, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27892649/thresholding-methods-for-lesion-segmentation-of-basal-cell-carcinoma-in-dermoscopy-images
#8
R Kaur, R LeAnder, N K Mishra, J R Hagerty, R Kasmi, R J Stanley, M E Celebi, W V Stoecker
PURPOSE: Algorithms employed for pigmented lesion segmentation perform poorly on dermoscopy images of basal cell carcinoma (BCC), the most common skin cancer. The main objective was to develop better methods for BCC segmentation. METHODS: Fifteen thresholding methods were implemented for BCC lesion segmentation. We propose two error metrics that better measure the type II error: Relative XOR Error and Lesion Capture Ratio. RESULTS: On training/test sets of 305 and 34 BCC images, respectively, five new techniques outperform two state-of-the-art methods used in segmentation of melanomas, based on the new error metrics...
November 28, 2016: Skin Research and Technology
https://www.readbyqxmd.com/read/27888160/preliminary-results-of-comparative-study-for-subsequent-photodynamic-therapy-versus-secondary-excision-after-primary-excision-for-treating-basal-cell-carcinoma
#9
Wenbo Bu, Mengli Zhang, Qian Zhang, Chunyu Yuan, Xu Chen, Fang Fang
Some basal cell carcinomas (BCCs) are indistinguishable from nevi based on clinical manifestations. Therefore, it is often difficult for the excision margins of the initial surgical treatment to achieve radical removal of the malignancy. This study was a comparative analysis of the clinical results of aminolevulinic acid (ALA)-photodynamic therapy (PDT) or secondary surgery after the primary excision. In total, 20 patients with preoperative clinical diagnoses of nevi underwent in situ resection. The postoperative pathological diagnoses confirmed all cases were BCC...
November 22, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27886433/the-burkholderia-cenocepacia-peptidoglycan-associated-lipoprotein-is-involved-in-epithelial-cell-attachment-and-elicitation-of-inflammation
#10
Ruth Dennehy, Maria Romano, Alessia Ruggiero, Yasmine F Mohamed, Simon L Dignam, Cristóbal Mujica Troncoso, Máire Callaghan, Miguel A Valvano, Rita Berisio, Siobhán McClean
The Burkholderia cepacia complex (Bcc) is a group of Gram-negative opportunistic pathogens causing infections in people with cystic fibrosis (CF). Bcc is highly antibiotic resistant, making conventional antibiotic treatment problematic. The identification of novel targets for anti-virulence therapies should improve therapeutic options for infected CF patients. We previously identified that the peptidoglycan-associated lipoprotein (Pal) was immunogenic in Bcc infected CF patients; however, its role in Bcc pathogenesis is unknown...
November 7, 2016: Cellular Microbiology
https://www.readbyqxmd.com/read/27884784/phenotypic-and-genomic-characterization-of-the-antimicrobial-producer-rheinheimera-sp-eprs3-isolated-from-the-medicinal-plant-echinacea-purpurea-insights-into-its-biotechnological-relevance
#11
Luana Presta, Emanuele Bosi, Marco Fondi, Isabel Maida, Elena Perrin, Elisangela Miceli, Valentina Maggini, Patrizia Bogani, Fabio Firenzuoli, Vincenzo Di Pilato, Gian Maria Rossolini, Alessio Mengoni, Renato Fani
In recent years, there has been increasing interest in plant microbiota; however, despite medicinal plant relevance, very little is known about their highly complex endophytic communities. In this work, we report on the genomic and phenotypic characterization of the antimicrobial compound producer Rheinheimera sp. EpRS3, a bacterial strain isolated from the rhizospheric soil of the medicinal plant Echinacea purpurea. In particular, EpRS3 is able to inhibit growth of different bacterial pathogens (Bcc, Acinetobacterbaumannii, and Klebsiellapneumoniae) which might be related to the presence of gene clusters involved in the biosynthesis of different types of secondary metabolites...
November 22, 2016: Research in Microbiology
https://www.readbyqxmd.com/read/27881944/-2518-a-g-mcp-1-but-not-403-g-a-rantes-gene-polymorphism-is-associated-with-enhanced-risk-of-basal-cell-carcinoma
#12
Michał Sobjanek, Monika Zabłotna, Aneta Szczerkowska-Dobosz, Katarzyna Ruckemann-Dziurdzińska, Malgorzata Sokolowska-Wojdylo, Roman Nowicki
INTRODUCTION: Polymorphic variants of MCP-1 and RANTES genes and their protein serum levels have been implicated in the increased risk and severity of several malignancies. However, the subject has not been explored in basal cell carcinoma (BCC) patients so far. AIM: To investigate the association between monocyte chemoattractant protein 1 (MCP-1) (-2518 A/G) and RANTES (-403 G/A) polymorphism and risk and clinical course of BCC. MATERIAL AND METHODS: The study group consisted of 150 unrelated patients with BCC and 140 healthy, unrelated, age- and sex-matched volunteers...
October 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27879972/responses-of-metastatic-basal-cell-and-cutaneous-squamous-cell-carcinomas-to-anti-pd1-monoclonal-antibody-regn2810
#13
Gerald S Falchook, Rom Leidner, Elizabeth Stankevich, Brian Piening, Carlo Bifulco, Israel Lowy, Matthew G Fury
BACKGROUND: Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (CSCC) share exposure to UV light as the dominant risk factor, and these tumors therefore harbor high mutation burdens. In other malignancies, high mutation burden has been associated with clinical benefit from therapy with antibodies directed against the Programmed Death 1 (PD-1) immune checkpoint receptor. Highly mutated tumors are more likely to express immunogenic tumor neoantigens that attract effector T cells, which can be unleashed by blockade of the PD-1 immune checkpoint...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27879334/intrinsic-resistance-of-burkholderia-cepacia-complex-to-benzalkonium-chloride
#14
Youngbeom Ahn, Jeong Myeong Kim, Ohgew Kweon, Seong-Jae Kim, Richard C Jones, Kellie Woodling, Gonçalo Gamboa da Costa, John J LiPuma, David Hussong, Bernard S Marasa, Carl E Cerniglia
: Pharmaceutical products that are contaminated with Burkholderia cepacia complex (BCC) bacteria may pose serious consequences to vulnerable patients. Benzyldimethylalkylammonium chloride (BZK) cationic surfactants are extensively used in medical applications and have been implicated in the coselection of antimicrobial resistance. The ability of BCC to degrade BZK, tetradecyldimethylbenzylammonium chloride (C14BDMA-Cl), dodecyldimethylbenzylammonium chloride (C12BDMA-Cl), decyldimethylbenzylammonium chloride (C10BDMA-Cl), hexyldimethylbenzylammonium chloride, and benzyltrimethylammonium chloride was determined by incubation in 1/10-diluted tryptic soy broth (TSB) to determine if BCC bacteria have the ability to survive and inactivate these disinfectants...
November 22, 2016: MBio
https://www.readbyqxmd.com/read/27876878/dependence-of-phase-configurations-microstructures-and-magnetic-properties-of-iron-nickel-fe-ni-alloy-nanoribbons-on-deoxidization-temperature-in-hydrogen
#15
Panpan Jing, Mengting Liu, Yongping Pu, Yongfei Cui, Zhuo Wang, Jianbo Wang, Qingfang Liu
Iron-nickel (Fe-Ni) alloy nanoribbons were reported for the first time by deoxidizing NiFe2O4 nanoribbons, which were synthesized through a handy route of electrospinning followed by air-annealing at 450 °C, in hydrogen (H2) at different temperatures. It was demonstrated that the phase configurations, microstructures and magnetic properties of the as-deoxidized samples closely depended upon the deoxidization temperature. The spinel NiFe2O4 ferrite of the precursor nanoribbons were firstly deoxidized into the body-centered cubic (bcc) Fe-Ni alloy and then transformed into the face-centered cubic (fcc) Fe-Ni alloy of the deoxidized samples with the temperature increasing...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27874047/energetics-of-vacancy-segregation-to-100-symmetric-tilt-grain-boundaries-in-bcc-tungsten
#16
Nanjun Chen, Liang-Liang Niu, Ying Zhang, Xiaolin Shu, Hong-Bo Zhou, Shuo Jin, Guang Ran, Guang-Hong Lu, Fei Gao
The harsh irradiation environment poses serious threat to the structural integrity of leading candidate for plasma-facing materials, tungsten (W), in future nuclear fusion reactors. It is thus essential to understand the radiation-induced segregation of native defects and impurities to defect sinks, such as grain boundaries (GBs), by quantifying the segregation energetics. In this work, molecular statics simulations of a range of equilibrium and metastable [100] symmetric tilt GBs are carried out to explore the energetics of vacancy segregation...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27872073/exploring-the-role-of-the-%C3%AE-loop-in-the-evolution-of-ceftazidime-resistance-in-the-pena-%C3%AE-lactamase-from-burkholderia-multivorans-an-important-cystic-fibrosis-pathogen
#17
Krisztina M Papp-Wallace, Scott A Becka, Magdalena A Taracila, Elise T Zeiser, Julian A Gatta, John J LiPuma, Robert A Bonomo
The unwelcome evolution of resistance to the advanced generation cephalosporin antibiotic, ceftazidime is hindering the effective therapy of Burkholderia cepacia complex (Bcc) infections. Regrettably, Bcc are highly resistant to most antibiotics, including polymyxins; ceftazidime and trimethoprim-sulfamethoxazole are the most effective treatment options. Unfortunately, resistance to ceftazidime is increasing and posing a health threat to populations susceptible to Bcc infection. We found that up to 36% of 146 tested Bcc clinical isolates were non-susceptible to ceftazidime...
November 21, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27871136/contribution-of-different-dispersal-sources-to-the-metabolic-response-of-lake-bacterioplankton-following-a-salinity-change
#18
Jérôme Comte, Silke Langenheder, Mercè Berga, Eva S Lindström
Dispersal can modify how bacterial community composition (BCC) changes in response to environmental perturbations, yet knowledge about the functional consequences of dispersal is limited. Here we hypothesize that changes in bacterial community production in response to a salinity disturbance depend on the possibility to recruit cells from different dispersal sources. To investigate this, we conducted an in situ mesocosm experiment where bacterial communities of an oligotrophic lake were exposed to different salinities (0, 18, 36 psu) for two weeks and subjected to dispersal of cells originating from sediments, air (mesocosms open to air deposition), both or none...
November 21, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27871055/microfluidic-device-for-label-free-quantitation-and-distinction-of-bladder-cancer-cells-from-the-blood-cells-using-micro-machined-silicon-based-electrical-approach-suitable-in-urinalysis-assays
#19
Seied Ali Hosseini, Somayeh Zanganeh, Elaheh Akbarnejad, Fatemeh Salehi, Mohammad Abdolahad
This paper introduces an integrated microfluidic chip as a promising tool to measure the concentration of bladder cancer cells (BCC) in urine samples. Silicon microchannels were used as trapping gates for both floated BCC and leukocytes which are found in the urine of patients. By the assistance of the gold electrodes patterned at the bottom of the micro gates, the capacitance of captured cancerous and blood cells were measured. Different membrane capacitance between BCC and leukocyte was the indicative signal for diagnosing the nature of captured cells in a urine like solution...
November 13, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27869728/a-holistic-model-of-care-to-support-those-living-with-and-beyond-cancer
#20
Tamara Cadet, Cindy Davis, Jacinta Elks, Patricia Wilson
BACKGROUND: Globally, the burden of cancer continues to increase and it is well-documented that while not a homogeneous population, cancer patients and cancer survivors face many physical, psychological, social, spiritual, and financial issues. Cancer care is shifting from a disease-focused to a patient-centered approach resulting in an increased need to address these concerns. METHODS: Utilizing a quality improvement approach, this paper describes an integrated cancer care model at Bloomhill Cancer Center (BCC) in Queensland, Australia that demonstrates the ability to meet the holistic needs of patients living with and beyond cancer and to identify opportunities for better practice and service provision...
November 18, 2016: Healthcare (Basel, Switzerland)
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