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https://www.readbyqxmd.com/read/29150868/patient-reported-health-outcomes-in-patients-with-non-melanoma-skin-cancer-and-actinic-keratosis-results-from-a-large-scale-observational-study-analysing-effects-of-diagnoses-and-disease-progression
#1
W G Philipp-Dormston, K Müller, B Novak, K Strömer, C Termeer, U Hammann, J Glutsch, G Kraehn-Senftleben, H Lübbert, M Koller, R M Szeimies
BACKGROUND: Non-melanoma skin cancer (NMSC) and actinic keratosis (AK) are very common among fair-skinned individuals. A disease continuum from AK to squamous cell carcinoma (SCC) has been frequently postulated. AK and NMSC may influence quality of life (QL) of patients, and it can be suspected that disease progression entails a QL reduction. The purpose of this study was to document QL in patients with NMSC and AK using the health-outcome questionnaire EQ-5D-5L. METHODS: The study was designed as a non-interventional, prospective, cross-sectional study...
November 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29149086/physiological-peculiarities-of-lignin-modifying-enzyme-production-by-the-white-rot-basidiomycete-coriolopsis-gallica-strain-bcc-142
#2
Vladimir Elisashvili, Eva Kachlishvili, Mikheil D Asatiani, Ramona Darlington, Katarzyna H Kucharzyk
Sixteen white-rot Basidiomycota isolates were screened for production of lignin-modifying enzymes (LME) in glycerol- and mandarin peel-containing media. In the synthetic medium, Cerrena unicolor strains were the only high laccase (Lac) (3.2-9.4 U/mL) and manganese peroxidase (MnP) (0.56-1.64 U/mL) producers while one isolate Coriolopsis gallica was the only lignin peroxidase (LiP) (0.07 U/mL) producer. Addition of mandarin peels to the synthetic medium promoted Lac production either due to an increase in fungal biomass (Funalia trogii, Trametes hirsuta, and T...
November 17, 2017: Microorganisms
https://www.readbyqxmd.com/read/29148079/insm1-a-novel-nuclear-marker-in-merkel-cell-carcinoma-cutaneous-neuroendocrine-carcinoma
#3
Patrick S Rush, Jason N Rosenbaum, Madhuchhanda Roy, Rebecca M Baus, Daniel D Bennett, Ricardo V Lloyd
Merkel cell carcinoma (MCC) is a rare, clinically aggressive, cutaneous neuroendocrine (NE) neoplasm. As a tumor with small, round, blue cells, the histologic differential diagnosis for MCC can include melanoma, metastatic small cell carcinoma (SCC), nodular hematopoietic tumors, basal cell carcinoma (BCC), atypical variants of squamous carcinoma, and the uncommon occurrence of primary cutaneous Ewing sarcoma. In cases with atypical histology or without the classic immunophenotype the diagnosis can be challenging...
November 17, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29146125/all-cause-mortality-in-patients-with-basal-and-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#4
Mackenzie R Wehner, Wilmarie Cidre Serrano, Adi Nosrati, Patrick Michael Schoen, Mary-Margaret Chren, John Boscardin, Eleni Linos
BACKGROUND: There are varying reports of the association of basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) with mortality. OBJECTIVE: To synthesize the available information on all-cause mortality after a diagnosis of BCC or SCC in the general population. METHODS: We searched PubMed (1966-present), Web of Science (1898-present), and Embase (1947-present) and hand-searched to identify additional records. All English articles that reported all-cause mortality in patients with BCC or SCC were eligible...
November 13, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29139363/cryosurgery-for-facial-and-scalp-lesions-of-basal-cell-carcinoma-a-study-in-29-elderly-patients
#5
Satish Savant, Sandeep Savant, Virendra N Sehgal
Basal cell carcinoma (BCC) is one of the pre-eminent tumors of the epidermis, recognized by explicit clinical-pathologic characteristics. It is relatively uncommon in South Asia including India and is amenable to a variety of modalities, including cryosurgery. The outcome of cryosurgery was evaluated in 18 men and 11 women, aged 58 to 83 years, who were treated with two freeze-thaw cycles of liquid nitrogen under local anesthesia, after requisite preparations. Of the 29 patients, 27 had complete clearance of the lesions in the course of 3 years of follow-up, while only 2 had a recurrence, one at 17 months and one at 23 months...
2017: Skinmed
https://www.readbyqxmd.com/read/29139000/effect-of-light-polarization-on-the-efficiency-of-photodynamic-therapy-of-basal-cell-carcinomas-an-in-vitro-cellular-study
#6
M JalalKamali, S N Nematollahi-Mahani, M Shojaei, A Shamsoddini, N Arabpour
In an in vitro study, the effect of light polarization on the efficiency of 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) of basal cell carcinoma (BCC) was investigated. Three states of light polarization (non-polarized, linearly polarized, and circularly polarized) were considered. Cells were exposed to green (532 pm 20 nm) irradiation from light emitting diodes. Cell survival was measured by the colorimetric assay (WST-1) and Trypan blue staining. The colorimetric assay showed a pronounced decrease in the cell viability (up to 30%) using polarized light compared to the non-polarized one in the wavelength region used...
November 15, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29137400/downregulation-of-the-sonic-hedgehog-gli-pathway-transcriptional-target-neogenin-1-is-associated-with-basal-cell-carcinoma-aggressiveness
#7
Bárbara S Casas, Christelle Adolphe, Pablo Lois, Nelson Navarrete, Natalia Solís, Eva Bustamante, Patricio Gac, Patricio Cabané, Ivan Gallegos, Brandon J Wainwright, Verónica Palma
Basal Cell Carcinoma (BCC) is one of the most diagnosed cancers worldwide. It develops due to an unrestrained Sonic Hedgehog (SHH) signaling activity in basal cells of the skin. Certain subtypes of BCC are more aggressive than others, although the molecular basis of this phenomenon remains unknown. We have previously reported that Neogenin-1 (NEO1) is a downstream target gene of the SHH/GLI pathway in neural tissue. Given that SHH participates in epidermal homeostasis, here we analyzed the epidermal expression of NEO1 in order to identify whether it plays a role in adult epidermis or BCC...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135512/cytokeratin-profile-of-basal-cell-carcinomas-according-to-the-degree-of-sun-exposure-and-to-the-anatomical-localization
#8
Ma Reyes García-de-la-Fuente, Maria Santacana, Joan Valls, Felip Vilardell, José Manuel Fernández Armenteros, Ramon Pujol, Eloi Gari, Josep Manel Casanova
Basal cell carcinoma (BCC) seems to originate from ultraviolet light-induced mutations involving the bulge or the outer sheath of the hair follicle cells. However, the etiopathogenic mechanisms involved in the development of these tumors in nonphotoexposed and in hairless areas remain unclear. The cytokeratin (CK) profile (including CK5/6, CK7, CK14, CK15, CK17, and CK19) from a series of different BCC subtypes developing in sun-exposed and non-sun-exposed areas, including hairless regions, was evaluated. The authors have observed that CK7 expression in BCC is associated with the anatomical localization of the tumor and its sun-exposition, but not with other factors such as histological subtype...
November 1, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29126641/microstructural-and-associated-chemical-changes-during-the-composting-of-a-high-temperature-biochar-mechanisms-for-nitrate-phosphate-and-other-nutrient-retention-and-release
#9
Stephen Joseph, Claudia I Kammann, Jessica G Shepherd, Pellegrino Conte, Hans-Peter Schmidt, Nikolas Hagemann, Anne M Rich, Christopher E Marjo, Jessica Allen, Paul Munroe, David R G Mitchell, Scott Donne, Kurt Spokas, Ellen R Graber
Recent studies have demonstrated the importance of the nutrient status of biochar and soils prior to its inclusion in particular agricultural systems. Pre-treatment of nutrient-reactive biochar, where nutrients are loaded into pores and onto surfaces, gives improved yield outcomes compared to untreated biochar. In this study we have used a wide selection of spectroscopic and microscopic techniques to investigate the mechanisms of nutrient retention in a high temperature wood biochar, which had negative effects on Chenopodium quinoa above ground biomass yield when applied to the system without prior nutrient loading, but positive effects when applied after composting...
November 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29125470/magnetic-behavior-of-metastable-fe-films-grown-on-ir-111
#10
Alberto Calloni, Matteo Cozzi, Madan Sangarashettyhalli Jagadeesh, Gianlorenzo Bussetti, Franco Ciccacci, Lamberto Duo
We investigated the growth of ultra-thin Fe films on Ir(111) by means of <i>in-situ</i> low energy electron diffraction and spin-resolved photoemission techniques. We observe a (1x1) diffraction pattern, characteristic of the <i>fcc</i> substrate, below 4 monolayers (ML). Then, a complex superstructure starts to develop, compatible with the formation of <i>bcc</i>-like Fe domains aligned with the substrate according to the Kourdjumov-Sachs orientation relationships. The analysis of the diffraction patterns reveals a progressive evolution towards a fully relaxed <i>bcc</i> lattice, characteristic of bulk Fe...
November 10, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29124688/uv-induced-molecular-signaling-differences-in-melanoma-and-non-melanoma-skin-cancer
#11
Feng Liu-Smith, Jinjing Jia, Yan Zheng
There are three major types of skin cancer: melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BCC and SCC are often referred to as non-melanoma skin cancer (NMSC). NMSCs are relatively non-lethal and curable by surgery, hence are not reportable in most cancer registries all over the world. Melanoma is the deadliest skin cancer. Its incidence rate (case number) is about 1/10th of that for NMSC, yet its death toll is ~8 fold higher than NMSC.Melanomas arise from melanocytes which are normally located on the basement membrane with dendrites extending into the epidermal keratinocytes...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29117441/actinic-keratosis-area-and-severity-index-akasi-is-associated-with-the-incidence-of-squamous-cell-carcinoma
#12
L Schmitz, T Gambichler, G Gupta, M Stücker, T Dirschka
BACKGROUND: Actinic keratoses (AKs) are commonly diagnosed clinically. Actinic keratosis area and severity index (AKASI) is a new easy-to-use tool to assess the severity of AK on the head. OBJECTIVE: To determine the association between chronically UV-induced tumours such as basal cell carcinomas (BCC) or squamous cell carcinomas (SCC) and AKASI. METHODS: We performed a retrospective analysis of patients who had undergone oncological surgery due to UV-induced tumours and who were assessed for AKASI and Physician's Global Assessment (PGA) prior to surgery...
November 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29114849/risk-of-skin-cancer-among-patients-with-myotonic-dystrophy-type-1-based-on-primary-care-physician-data-from-the-united-kingdom-clinical-practice-research-datalink
#13
Youjin Wang, Ruth M Pfeiffer, Rotana Alsaggaf, Wilhelmine Meeraus, Julia C Gage, Lesley A Anderson, Renée C Bremer, Nikoletta Nikolenko, Hanns Lochmuller, Mark H Greene, Shahinaz M Gadalla
Myotonic dystrophy type 1 (DM1) is an inherited multisystem neuromuscular disorder caused by a CTG trinucleotide repeat expansion in the DMPK gene. Recent evidence documents that DM1 patients have an increased risk of certain cancers, but whether skin cancer risks are elevated is unclear. Using the U.K. Clinical Practice Research Datalink (CPRD), we identified 1,061 DM1 patients and 15,119 DM1-free individuals matched on gender, birth year (±2 years), attending practice, and registration year (±1 year). We calculated the hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of DM1 diagnosis with skin cancer risk using Cox proportional hazards models, for all skin cancers combined and by histological subtype...
November 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29113122/investigation-of-interaction-between-dislocation-loop-and-coherent-twin-boundary-in-bcc-ta-film-during-nanoindentation
#14
Cheng Huang, Xianghe Peng, Bo Yang, Yinbo Zhao, Shayuan Weng, Tao Fu
In this work, the interaction between dislocation loop (DL) and coherent twin boundary (CTB) in a body-centered cubic (BCC) tantalum (Ta) film during nanoindentation was investigated with molecular dynamics (MD) simulation. The formation and propagation of <111> full DLs in the nanotwinned (nt) Ta film during the indentation was observed, and it was found that CTB can strongly affect the stress distribution in the Ta film, and thus change the motion and type of dislocations. There are three kinds of mechanisms for the interaction between DL and CTB in a twinned BCC Ta film: (i) dislocation absorption, (ii) dislocation desorption, and (iii) direct slip transmission...
November 6, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29111985/occupational-uv-exposure-is-a-major-risk-factor-for-basal-cell-carcinoma-results-of-the-population-based-case-control-study-fb-181
#15
Jochen Schmitt, Eva Haufe, Freya Trautmann, Hans-Joachim Schulze, Peter Elsner, Hans Drexler, Andrea Bauer, Stephan Letzel, Swen Malte John, Manigé Fartasch, Thomas Brüning, Andreas Seidler, Susanne Dugas-Breit, Michal Gina, Wobbeke Weistenhöfer, Klaus Bachmann, Ilka Bruhn, Berenice Mareen Lang, Sonja Bonness, Jean Pierre Allam, William Grobe, Thoralf Stange, Stephan Westerhausen, Peter Knuschke, Marc Wittlich, Thomas Ludwig Diepgen
OBJECTIVE: To investigate to role of occupational and non-occupational UV-exposure concerning the development of basal cell carcinoma (BCC). METHODS: We undertook a population-based multi-center case-control study. Patients with first incident BCC (n = 836) were propensity score matched by age and sex to controls without skin cancer (n = 836). Sociodemographic characteristics, clinical characteristics and lifetime UV-exposure were assessed by trained investigators...
November 3, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29111235/genomic-stability-in-syndromic-basal-cell-carcinoma
#16
Audris Chiang, Prajakta D Jaju, Prag Batra, Melika Rezaee, Ervin H Epstein, Jean Y Tang, Kavita Y Sarin
Basal cell cancers (BCCs) are characterized by up-regulation of Hedgehog pathway through loss of Patched1 or activation of Smoothened, and smoothened-inhibitors such as vismodegib are effective therapies for advanced BCCs. Although most BCCs are sporadic, rare individuals with Basal Cell Nevus Syndrome (BCNS) harbor germline defects in Patched1 and develop up to hundreds of tumors that are histopathologically indistinguishable from sporadic BCCs. Interestingly, BCNS-BCCs are more responsive to Smoothened-inhibitors than sporadic BCCs, with minimal development of resistance...
October 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29104696/ulcerated-metatypical-basal-cell-carcinoma-of-the-forehead
#17
Jose Cardoso, Uwe Wollina, Georgi Tchernev
An 81-year-old male presented with an ulcerated lesion on the frontal area. The lesion had started three years before with a small ulceration and was initially treated with a cream of betamethasone and fusidic acid twice daily for several months. The clinical impression was ulcerated basal cell carcinoma (BCC). The histopathological findings after surgical excision were consistent with metatypical or basosquamous carcinoma. The importance of metatypical and basosquamous carcinomas is their potential for a more aggressive behaviour than conventional BCC, both regarding local recurrences and metastatic disease...
October 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29103202/stain-free-histopathology-of-basal-cell-carcinoma-by-dual-vibration-resonance-frequency-cars-microscopy
#18
Norbert Kiss, Ádám Krolopp, Kende Lőrincz, András Bánvölgyi, Róbert Szipőcs, Norbert Wikonkál
Basal cell carcinoma (BCC) is the most common malignancy in Caucasians. Nonlinear microscopy has been previously utilized for the imaging of BCC, but the captured images do not correlate with H&E staining. Recently, Freudiger et al. introduced a novel method to visualize tissue morphology analogous to H&E staining, using coherent anti-Stokes Raman scattering (CARS) technique. In our present work, we introduce a novel algorithm to post-process images obtained from dual vibration resonance frequency (DVRF) CARS measurements to acquire high-quality pseudo H&E images of BCC samples...
November 4, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29102935/ft-ir-spectroscopy-study-in-early-diagnosis-of-skin-cancer
#19
Maria Kyriakidou, Jane Anastassopoulou, Aristeidis Tsakiris, Maria Koui, Theophile Theophanides
BACKGROUND/AIM: Mid-infrared spectroscopy (4000-500 cm(-1)) was used to analyze the spectral changes and differences of the characteristic absorption bands of the skin components due to cancer development for early clinical diagnosis. MATERIALS AND METHODS: Human biopsies from basal cell carcinoma, malignant melanoma, and nevus were used, while normal skin tissue served as a control. RESULTS: The high quality of Fourier-transform infrared (FT-IR) spectra showed that upon cancer development the intensity of the absorption band at approximately 3062 cm(-1) was increased, indicating that most of the proteins had the configuration of amide B and the β-sheet protein structure predominated...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29102653/combination-vismodegib-and-photodynamic-therapy-for-multiple-basal-cell-carcinomas
#20
Jason M Rizzo, Robert J Segal, Nathalie C Zeitouni
BACKGROUND: Oral vismodegib therapy and photodynamic therapy (PDT) are non-invasive treatments for basal cell carcinoma (BCC) with overlapping utility in widespread BCCs and patients who are poor surgical candidates. There is no published study to date investigating the combination use of PDT with vismodegib to optimize individual response rates. OBJECTIVE: To evaluate the combination of red light PDT and vismodegib therapy in patients with multiple nodular BCCs...
November 1, 2017: Photodiagnosis and Photodynamic Therapy
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