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https://www.readbyqxmd.com/read/29674324/indications-for-the-performance-of-intracranial-endovascular-neurointerventional-procedures-a-scientific-statement-from-the-american-heart-association
#1
REVIEW
Clifford J Eskey, Philip M Meyers, Thanh N Nguyen, Sameer A Ansari, Mahesh Jayaraman, Cameron G McDougall, J Kevin DeMarco, William A Gray, David C Hess, Randall T Higashida, Dilip K Pandey, Constantino Peña, Hermann C Schumacher
Intracranial endovascular interventions provide effective and minimally invasive treatment of a broad spectrum of diseases. This area of expertise has continued to gain both wider application and greater depth as new and better techniques are developed and as landmark clinical studies are performed to guide their use. Some of the greatest advances since the last American Heart Association scientific statement on this topic have been made in the treatment of ischemic stroke from large intracranial vessel occlusion, with more effective devices and large randomized clinical trials showing striking therapeutic benefit...
April 19, 2018: Circulation
https://www.readbyqxmd.com/read/29667581/relation-between-bioresorbable-scaffold-sizing-using-qca-dmax-and-long-term-clinical-outcomes-in-1-232-patients-from-3-study-cohorts-absorb-cohort-b-absorb-extend-and-absorb-ii
#2
Yuki Katagiri, Yoshinobu Onuma, Taku Asano, Ply Chichareon, Carlos Collet, Yosuke Miyazaki, Jan J Piek, Joanna J Wykrzykowska, Alexandre Abizaid, John A Ormiston, Bernard Chevalier, Patrick W Serruys
AIMS: This study sought to investigate the long-term clinical outcomes related to scaffold sizing based on quantitative coronary angiography. METHODS AND RESULTS: A total of 1,248 patients who received Absorb bioresorbable scaffolds in the ABSORB Cohort B, ABSOR EXTEND, ABSORB II trials were included in the analysis. The incidence of MACE (a composite of cardiac death, any myocardial infarction [MI], and ischemia-driven target lesion revascularization [ID-TLR]) was analysed according to the Dmax subclassification of oversized scaffold group versus non-oversized (any undersize) scaffold group...
April 17, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29652672/early-discontinuation-of-prasugrel-or-clopidogrel-in-acute-coronary-syndromes-insights-from-the-trilogy-acs-trial
#3
Andrew T Yan, Matthew T Roe, Megan Neely, Derek D Cyr, Harvey White, Keith A A Fox, Dorairaj Prabhakaran, Paul W Armstrong, Erik M Ohman, Shaun G Goodman
BACKGROUND: In the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes (TRILOGY ACS) trial of patients with non-ST-segment elevation acute coronary syndrome managed medically without revascularization, treated with prasugrel versus clopidogrel for less than or equal to 30 months after index acute coronary syndrome, post-hoc analyses showed a divergence of treatment effect in favor of prasugrel after 12 months. Potential influential factors, including a potential late treatment effect after early study drug discontinuation in the intention-to-treat analysis, have not been explored...
April 12, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29644451/emerging-therapies-in-metastatic-prostate-cancer
#4
REVIEW
Daniel W Sonnenburg, Alicia K Morgans
PURPOSE OF REVIEW: In the last decade, there have been multiple landmark therapeutic advances for the treatment of metastatic prostate cancer, both in the castration-resistant and hormone-sensitive setting. In this review, we highlight recent progress and ongoing trials for metastatic prostate cancer, including advances in chemotherapy, androgen receptor-directed therapy, targeted therapies, and immunotherapy. RECENT FINDINGS: Several landmark studies for men with metastatic hormone-sensitive prostate cancer demonstrated improvement in overall survival with the addition of docetaxel chemotherapy or abiraterone acetate to standard androgen deprivation therapy...
April 11, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29628705/ultrasound-guided-versus-landmark-guided-corticosteroid-injection-in-patients-with-rotator-cuff-syndrome-randomised-controlled-trial
#5
Himanshu Bhayana, Puneet Mishra, Anupama Tandon, Amite Pankaj, Rohit Pandey, Raskesh Malhotra
Objective: Impingement syndrome is the most common differential in a patient presenting to an orthopaedic OPD with shoulder pain. Impingement syndrome is often managed with subacromial corticosteroid injection, which can be instilled using either landmark guided (LMG) approach or with the assistance of ultrasound (US). This study was envisaged to enquire whether ultrasound assistance improves the accuracy, efficacy or safety profile of the injection. Methods: 60 patients of rotator cuff syndrome underwent diagnostic ultrasound...
March 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29628554/comparison-of-ultrasound-with-peripheral-nerve-stimulator-guided-technique-for-supraclavicular-block-in-upper-limb-surgeries-a-randomized-controlled-trial
#6
Vinu Mervick Alfred, Gnanasekaran Srinivasan, Mamie Zachariah
Background: The supraclavicular approach is considered to be the easiest and most effective approach to block the brachial plexus for upper limb surgeries. The classical approach using the anatomical landmark technique was associated with higher failure rates and complications. Ultrasonography (USG) guidance and peripheral nerve stimulator (PNS) have improved the success rates and safety margin. Aims: The aim of the present study is to compare USG with PNS in supraclavicular brachial plexus block for upper limb surgeries with respect to the onset of motor and sensory blockade, total duration of blockade, procedure time, and complications...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29627360/the-occult-hemodynamically-significant-left-main-stenosis-in-the-asymptomatic-patient-reconciling-the-visual-functional-mismatch-a-case-report-and-review-of-screening-appropriateness-and-assessment-of-left-main-in-patient-with-multi-vessel-cad
#7
REVIEW
Maryam Balouch, Jennifer Ballard-Hernandez, Min Kim, Arnold Seto, Morton Kern
We present a 40 year old asymptomatic man with mild left main artery narrowing who demonstrated extreme discordance between symptom presentation and ischemic burden i.e. visual (angiographic) and ischemic (functional) mismatch. The use of an appropriately selected screening stress test can lead to an appropriate decision for revascularization, supported by landmark risk assessment documents and revascularization trials.
February 21, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29623227/fulminant-diabetes-in-a-patient-with-advanced-melanoma-on-nivolumab
#8
Nora Chokr, Hafsa Farooq, Elizabeth Guadalupe
Background: Anti-PD-1 agents were approved for advanced melanoma after the landmark trial Checkmate-037. Anti-PD-1 agents can breach immunologic tolerance. Fulminant diabetes is an immune endocrinopathy that results from a violent immune attack leading to complete destruction of pancreatic beta cells in genetically predisposed people. We present a rare case of fulminant diabetes precipitated by anti-PD-1 immunotherapy. Case: A 61-year-old male with advanced melanoma presented with a three-day history of nausea, vomiting, and malaise...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29622155/lack-of-association-between-heart-failure-and-incident-cancer
#9
Senthil Selvaraj, Deepak L Bhatt, Brian Claggett, Luc Djoussé, Sanjiv J Shah, Jiaying Chen, Tasnim F Imran, Saadia Qazi, Howard D Sesso, J Michael Gaziano, Deborah Schrag
BACKGROUND: Several recent studies have suggested an increased cancer risk among patients with heart failure (HF). However, these studies are constrained by limited size and follow-up, lack of comprehensive data on other health attributes, and adjudicated cancer outcomes. OBJECTIVES: This study sought to determine whether HF is associated with cancer incidence and cancer-specific mortality. METHODS: The study assembled a cohort from the Physicians' Health Studies I and II, 2 randomized controlled trials of aspirin and vitamin supplements conducted from 1982 to 1995 and from 1997 to 2011, respectively, that included annual health evaluations and determination of cancer and HF diagnoses...
April 10, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29622098/diagnosis-and-management-of-acute-ischemic-stroke
#10
REVIEW
Tasneem F Hasan, Alejandro A Rabinstein, Erik H Middlebrooks, Neil Haranhalli, Scott L Silliman, James F Meschia, Rabih G Tawk
Acute ischemic stroke (AIS) is among the leading causes of death and long-term disability. Intravenous tissue plasminogen activator has been the mainstay of acute therapy. Recently, several prospective randomized trials documented the value of endovascular revascularization in selected patients with large-vessel occlusion within the anterior circulation. This finding has led to a paradigm shift in the management of AIS, including wide adoption of noninvasive neuroimaging to assess vessel patency and tissue viability, with the supplemental and independent use of intravenous tissue plasminogen activator to improve clinical outcomes...
April 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29618485/ultrasound-guidance-for-internal-jugular-vein-cannulation-in-picu-a-randomised-controlled-trial
#11
Tiago Henrique de Souza, Marcelo Barciela Brandão, Thiago Martins Santos, Ricardo Mendes Pereira, Roberto José Negrão Nogueira
OBJECTIVE: We investigated whether ultrasound guidance was advantageous over the anatomical landmark technique when performed by inexperienced paediatricians. DESIGN: Randomised controlled trial. SETTING: A paediatric intensive care unit of a teaching hospital. PATIENTS: 80 children (aged 28 days to <14 years). INTERVENTIONS: Internal jugular vein cannulation with ultrasound guidance in real time or the anatomical landmark technique...
April 4, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29608501/through-the-decades-%C3%AE-blocker-use-and-outcomes-in-acute-coronary-syndromes
#12
Alina Kukin, Zachary R Noel, Kristin Watson
Beta-adrenergic receptor antagonists, or β-blockers, have been a cornerstone of treatment in patients with acute coronary syndromes (ACS) for more than 4 decades. First studied in the 1960s, β-blockers in ACS have been shown to decrease the risk of death, recurrent ischemic events, and arrhythmias by reducing catecholamine-mediated effects and reducing myocardial oxygen demand. Through the decades, the β-blocker of choice, timing of initiation, duration of therapy, and dosing have evolved considerably. Despite having clear benefits in certain patient populations (eg, patients with systolic dysfunction who are hemodynamically stable), the benefit of β-blockers in other populations (ie, in patients at low risk for complications receiving modern revascularization therapies and optimal medical management) remains unclear...
May 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29601355/how-to-prevent-food-allergy-during-infancy-what-has-changed-since-2013
#13
William J Lavery, Amal Assa'ad
PURPOSE OF REVIEW: The purpose of this review is to summarize recent studies and emerging consensus guidelines regarding food allergy prevention in infants of the past 5 years. RECENT FINDINGS: Prior to 2013, the general consensus regarding prevention of food allergy in infants was to recommend delayed introduction or complete avoidance of commonly allergenic foods, such as milk, egg and peanut. However, in the past 5 years, several landmark studies have been conducted, particularly with peanut...
March 29, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29582979/contemporary-endovascular-techniques-for-the-curative-treatment-of-cerebral-arteriovenous-malformations-and-review-of-neurointerventional-outcomes
#14
Pascal J Mosimann, René Chapot
INTRODUCTION: Since the first landmark randomized trials on unruptured bAVMs were published, there has been emerging concerns about the role of endovascular therapy. For bAVMs considered inoperable, embolization remains an option worth considering, especially in young patients presenting with a rupture. We aimed to review the curative potential of contemporary stand-alone embolization techniques enabling high occlusion rates and their respective short and long term safety profile. PATIENTS AND METHODS: We performed a PubMed search with the terms "curative embolization of brain arteriovenous malformations" and "endovascular cure of brain arteriovenous malformations" focusing on the last ten years (2008-2018) and compliant to the PRISMA reporting guidelines...
March 26, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29582679/does-the-real-time-ultrasound-guidance-provide-safer-venipuncture-in-implantable-venous-port-implantation
#15
İlknur Yıldırım, Ayşe Çiğdem Tütüncü, Süleyman Bademler, İlker Özgür, Mukaddes Demiray, Hasan Karanlık
AIM: To examine whether the real-time ultrasound-guided venipuncture for implantable venous port placement is safer than the traditional venipuncture. METHODS: The study analyzed the results of 2153 venous ports placed consecutively from January 2009 to January 2016. A total of 922 patients in group 1 and 1231 patients in group 2 were admitted with venous port placed using the traditional landmark subclavian approach and real-time ultrasound-guided axillary approach, respectively...
March 1, 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29581202/real-world-effects-of-medications-for-chronic-obstructive-pulmonary-disease-protocol-for-a-uk-population-based-non-interventional-cohort-study-with-validation-against-randomised-trial-results
#16
Kevin Wing, Elizabeth Williamson, James R Carpenter, Lesley Wise, Sebastian Schneeweiss, Liam Smeeth, Jennifer K Quint, Ian Douglas
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a progressive disease affecting 3 million people in the UK, in which patients exhibit airflow obstruction that is not fully reversible. COPD treatment guidelines are largely informed by randomised controlled trial results, but it is unclear if these findings apply to large patient populations not studied in trials. Non-interventional studies could be used to study patient groups excluded from trials, but the use of these studies to estimate treatment effectiveness is in its infancy...
March 25, 2018: BMJ Open
https://www.readbyqxmd.com/read/29580950/the-value-of-early-depth-of-response-in-predicting-long-term-outcome-in-egfr-mutant-lung-cancer
#17
Chee Khoon Lee, Sally Lord, Ian Marschner, Yi Long Wu, Lecia Sequist, Rafael Rosell, Masahiro Fukuoka, Tetsuya Mitsudomi, Rebecca Asher, Lucy Davies, Val Gebski, Richard Gralla, Tony Mok, James Chih-Hsin Yang
INTRODUCTION: Traditionally, marked tumor shrinkage has been assumed to portend better outcome. We investigated whether depth of tumor response was associated with improved survival outcomes in advanced EGFR-mutant non-small cell lung cancer (NSCLC). METHODS: Individual patient data from randomized trials (EURTAC, IPASS, ENSURE, LUX-Lung 3, and LUX-Lung 6) were used. The association of depth of response with progression-free survival (PFS) and overall survival (OS) was examined using landmark analyses...
March 23, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29578207/use-of-oral-anticoagulants-in-patients-with-atrial-fibrillation-and-renal-dysfunction
#18
REVIEW
Tatjana S Potpara, Charles J Ferro, Gregory Y H Lip
Atrial fibrillation (AF) and chronic kidney disease (CKD) are increasingly prevalent in the general population and share common risk factors such as older age, hypertension and diabetes mellitus. The presence of CKD increases the risk of incident AF, and, likewise, AF increases the risk of CKD development and/or progression. Both conditions are associated with substantial thromboembolic risk, but patients with advanced CKD also exhibit a paradoxical increase in bleeding risk. In the landmark randomized clinical trials that compared non-vitamin K antagonist oral anticoagulants (NOACs) with warfarin for thromboprophylaxis in patients with AF, the efficacy and safety of NOACs in patients with mild-to-moderate CKD were similar to those in patients without CKD...
March 26, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29578025/the-role-of-the-right-superior-temporal-gyrus-in-stimulus-centered-spatial-processing
#19
Priyanka P Shah-Basak, Peii Chen, Kevin Caulfield, Jared Medina, Roy H Hamilton
Although emerging neuropsychological evidence supports the involvement of temporal areas, and in particular the right superior temporal gyrus (STG), in allocentric neglect deficits, the role of STG in healthy spatial processing remains elusive. While several functional brain imaging studies have demonstrated involvement of the STG in tasks involving explicit stimulus-centered judgments, prior rTMS studies targeting the right STG did not find the expected neglect-like rightward bias in size judgments using the conventional landmark task...
March 22, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29574581/new-algorithm-for-the-prediction-of-cardiovascular-risk-in-symptomatic-adults-with-stable-chest-pain
#20
REVIEW
Muralidhar R Papireddy, Carl J Lavie, Abhizith Deoker, Hadii Mamudu, Timir K Paul
PURPOSE OF REVIEW: To review the landmark studies in predicting obstructive coronary artery disease (CAD) in symptomatic patients with stable chest pain and identify better prediction tools and propose a simplified algorithm to guide the health care providers in identifying low risk patients to defer further testing. RECENT FINDINGS: There are a few risk prediction models described for stable chest pain patients including Diamond-Forrester (DF), Duke Clinical Score (DCS), CAD Consortium Basic, Clinical, and Extended models...
March 24, 2018: Current Cardiology Reports
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