Daphne L van der Velden, Geert A Cirkel, Julia M Houthuijzen, E van Werkhoven, Jeanine M L Roodhart, Laura G M Daenen, Sovann Kaing, Johan Gerrits, Nanda M Verhoeven-Duif, Cecile Grootscholten, Henk Boot, Cristisiana Sessa, Haiko J Bloemendal, Filip Y De Vos, Emile E Voest
PURPOSE: Chemotherapy-resistance remains a major obstacle to effective anti-cancer treatment. We previously showed that platinum analogs cause the release of two fatty acids. These platinum-induced fatty acids (PIFAs) induced complete chemoresistance in mice, whereas co-administration of a COX-1 inhibitor, indomethacin, prevented PIFA release and significantly enhanced chemosensitivity. To assess the safety of combining indomethacin with platinum-based chemotherapy, and to explore its efficacy and associated PIFA levels, a multi-center phase I trial was conducted...
March 24, 2018: Cancer Chemotherapy and Pharmacology