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Dermatofibrosarcoma

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https://www.readbyqxmd.com/read/28191686/dermoscopy-of-uncommon-variants-of-dermatofibrosarcoma-protuberans
#1
Claudia Costa, Milena Cappello, Giuseppe Argenziano, Vincenzo Piccolo, Massimiliano Scalvenzi
Darier-Ferrand dermatofibrosarcoma protuberans (DFSP) is a locally aggressive fibrohistiocytic tumour with a low metastatic potential.(1) Because of its rarity, slow progression and lack of early clinical clues, the diagnosis of DFSP is often delayed. Classical DFSP clinically appeared like an indurated, irregularly-shaped plaques exhibiting flesh to reddish-brown colour. Some lesions also showed thin teleangectasia on the surface (Fig. 1, a). This article is protected by copyright. All rights reserved.
February 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28154469/operative-management-of-dermatofibrosarcoma-protuberans-of-the-breast
#2
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28150334/application-of-col1a1-pdgfb-fusion-gene-detection-by-fluorescence-in%C3%A2-situ-hybridization-in-biopsy-tissue-of-dermatofibrosarcoma-protuberans
#3
Zhang Zhang, Huijiao Chen, Min Chen, Xin He, Yiying Wang, Hongying Zhang
Several uncommon variants of dermatofibrosarcoma protuberans (DFSP) and the limitations of small biopsies render pathological diagnosis difficult. The aim of this study was to analyze the utility of fluorescence in situ hybridization (FISH) in the detection of the collagen type I-α1/platelet derived growth factor-β (COL1A1-PDGFB) fusion gene in biopsies of DFSP. Twenty-three consecutive biopsy specimens of DFSP were reviewed for clinicopathological features and examined with the COL1A1-PDGFB fusion probe and PDGFB break-apart probe using FISH analysis...
February 2, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28134725/sclerosing-dermatofibrosarcoma-protuberans-shows-significant-overlap-with-sclerotic-fibroma-in-both-routine-and-immunohistochemical-analysis-a-potential-diagnostic-pitfall
#4
Maram Yousef Odeh Abdaljaleel, Jeffrey P North
Dermatofibrosarcoma protuberans (DFSP) is an uncommon, low-to-intermediate grade sarcoma with several histologic variants, including pigmented (Bednar tumor), sclerosing, myxoid, atrophic, and DFSP with fibrosarcomatous changes. Two patterns of sclerosis in DFSP can be observed, a sclerotic fibroma-like pattern and a morphea/lichen sclerosus-like pattern. Partial biopsies of sclerosing DFSPs with the sclerotic fibroma pattern can be misdiagnosed as sclerotic fibroma or other benign sclerosing tumors (eg, perineurioma, dermatofibroma)...
February 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28110710/imatinib-in-dermatofibrosarcoma-targeted-therapy-or-immunotherapy
#5
Selma Ugurel, Jürgen C Becker
There is increasing evidence that certain kinase inhibitors are able to foster two strategies, i.e. inhibition of oncogenic activated molecular pathways and modulation of immunological processes. In this respect, the study of Tazzari et al. is of great interest because it shows both effects for the kinase inhibitor imatinib in dermatofibrosarcoma protuberans.
February 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28108880/unusual-signal-patterns-of-break-apart-fish-probes-used-in-the-diagnosis-of-soft-tissue-sarcomas
#6
Gergő Papp, Dóra Mihály, Zoltán Sápi
Break-apart FISH probes are the most popular and reliable type of FISH probes used to confirm certain pathological diagnoses. The interpretation is usually easy, however, in some instances it is not so unequivocal. Our aim was to reveal and elucidate the problems occurring in the process of evaluation of the break-apart probe results. Altogether 301 soft tissue sarcomas with confirmed molecular tests using break-apart probes were assessed to reveal the frequency and type of unusual signal pattern. Among 89 synovial sarcoma (SS18) 11%, 12 alveolar rhabdomyosarcoma (FOXO1) 50%, 53 myxoid liposarcoma (DDIT3) 7...
January 20, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28056985/a-single-institutional-review-of-68-patients-with-dermatofibrosarcoma-protuberans-wide-re-excision-after-inadequate-previous-surgery-results-in-a-high-rate-of-local-control
#7
Kamran Harati, Kim Lange, Ole Goertz, Armin Lahmer, Nicolai Kapalschinski, Ingo Stricker, Marcus Lehnhardt, Adrien Daigeler
BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a cutaneous soft tissue sarcoma characterized by an indolent but aggressive local growth. Unplanned excisions with positive margins are common, and the prognostic impact of radical re-excisions is still unclear. The aim of the present study was to identify prognostic indicators of recurrence-free survival (RFS) in patients with DFSP through a long-term follow-up. We tried particularly to determine the prognostic impact of surgical margins and re-excisions in patients after earlier inadequate surgery...
January 5, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28045748/superficial-acral-fibromyxoma-report-of-13-cases-with-new-immunohistochemical-findings
#8
MULTICENTER STUDY
Daniella Cullen, José Luis Díaz Recuero, Roberto Cullen, José Luis Rodríguez Peralto, Heinz Kutzner, Luis Requena
BACKGROUND: Superficial acral fibromyxoma (SAF) is a benign, soft tissue neoplasm preferably located on the digits. METHODS: We collected 13 cases of SAF and evaluated their clinical, histopathologic, and immunohistochemical features. RESULTS: This study included 9 males and 4 females, median age 54 years. The patients presented with a solitary asymptomatic or tender mass, most of them arising on fingers or toes. Histopathologically all lesions consisted of nonencapsulated dermal nodules, composed of spindled cells with variable myxoid and/or fibrotic stroma...
January 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28027201/incidence-and-clinical-features-of-rare-cutaneous-malignancies-in-olmsted-county-minnesota-2000-to-2010
#9
Stanislav N Tolkachjov, Adam R Schmitt, John G Muzic, Amy L Weaver, Christian L Baum
BACKGROUND: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data. OBJECTIVE: To determine the incidence of several rare nonmelanoma skin cancers. MATERIALS AND METHODS: The authors conducted a retrospective chart review of a population-based cohort between the years 2000 and 2010. Residents of Olmsted County, Minnesota, who were diagnosed with a biopsy-proven nonmelanoma skin cancer-excluding basal cell carcinoma and squamous cell carcinoma-were included in this study...
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28018683/nodular-fasciitis-complicating-a-staged-surgical-excision-of-dermatofibrosarcoma-protuberans
#10
C Helen Malone, Brandon Goodwin, Richard F Wagner, Vicente Resto, Brent Kelly
Dermatofibrosarcoma protuberans (DFSP) is an unusual spindle cell tumor with a high rate of local recurrence with traditional excision. Fortunately, Mohs micrographic surgery yields excellent cure rates for this neoplasm due to contiguous tumor spread and meticulous tumor mapping and margin analysis. We present the unique case of a patient treated with a modified Mohs technique with an analysis of the final margin with permanent sections, who developed a spindle cell neoplasm in the margins of her second stage excision consistent with nodular fasciitis...
2016: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28012879/dermatofibroma-of-the-eyelid-with-monster-cells
#11
Frederick A Jakobiec, Yufei Tu, Fouad R Zakka, Arthur K F Tong
Dermatofibromas are most frequently encountered in women on the lower extremities, often after minor trauma. A 64-year-old woman developed a recurrent lesion of the right lower eyelid. It harbored "monster cells" that were large, with either multiple nuclei or a single, large, convoluted and hyperchromatic nucleus. The presence of these cells does not signify a malignant transformation. The background cells were either histiocytoid (many were adipophilin-positive), spindled cells, or dendritiform cells without mitoses...
December 21, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27984233/dermatofibrosarcoma-protuberans-like-tumor-with-col1a1-copy-number-gain-in-the-absence-of-t-17-22
#12
Jad Saab, Ian M Rosenthal, Lu Wang, Klaus J Busam, Kishwer S Nehal, Mark A Dickson, Meera R Hameed, Travis J Hollmann
A 57-year-old woman presented with a 3-year history of a progressive firm plaque on the right cheek. Skin biopsies revealed a bland, storiform, spindle-cell proliferation involving the deep dermis and subcutaneous fat. By immunohistochemistry, the tumor cells were diffusely positive for CD34 and caldesmon with multifocal reactivity for epithelial membrane antigen and focal, weak staining for smooth muscle actin. Retinoblastoma protein expression was not detectable in tumor cells by immunohistochemistry. An interphase fluorescence in situ hybridization analysis for platelet-derived growth factor B (PDGFB) gene rearrangement was negative...
December 14, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27979330/-what-surgery-for-recurrent-darier-ferrand-sarcoma-of-the-chest-wall
#13
S Rabiou, Y Ouadnouni, B Efared, L Belliraj, I Issoufou, F Z Ammor, J Ghalimi, M Lakranbi, R Sani, A Oufkir, M Smahi
INTRODUCTION: Dermatofibrosarcoma protuberans (Darrier-Ferrand sarcoma, DFSP) is an uncommon tumor. This sarcoma has a tendency to local recurrence, requiring a wide surgical resection. OBSERVATION: We report herein two cases of patients presenting with recurrent dermatofibrosarcoma protuberans after several surgical resections. A wide surgical resection with guided tissue regenaration has been performed in one case, whereas the second case required a skin graft...
December 12, 2016: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/27976423/mohs-micrographic-surgery-of-rare-cutaneous-tumors
#14
Sophie C Flohil, Charlotte B van Lee, Jessica Beisenherz, Marc A M Mureau, Lucy I H Overbeek, Tamar Nijsten, Renate R van den Bos
BACKGROUND: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumors are poorly defined. OBJECTIVE: Investigate the recurrence rate after MMS for rare cutaneous tumors at a university center. METHODS & MATERIALS: Retrospective review of all rare cutaneous tumors treated with MMS at a large university center between January 2008 and December 2012. To detect all recurrences, patients were linked to The nationwide network and registry of histo- and cytopathology (PALGA)...
December 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27973652/prognostic-factors-of-survival-in-dermatofibrosarcoma-protuberans-reply
#15
Maressa C Criscito, Kathryn J Martires, Jennifer A Stein
No abstract text is available yet for this article.
December 1, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27973651/prognostic-factors-of-survival-in-dermatofibrosarcoma-protuberans
#16
Swathikan Chidambaram, En Lin Goh
No abstract text is available yet for this article.
December 1, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27922973/incidence-and-outcomes-of-dermatofibrosarcoma-protuberans-in-the-us-pediatric-population
#17
Gustavo A Rubio, Andrea Alvarado, David J Gerth, Jun Tashiro, Seth R Thaller
BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a low-grade soft tissue sarcoma. In the pediatric population, DFSP is exceedingly rare. Aim of this study was to describe the epidemiology and clinical outcomes in a large pediatric cohort. METHODS: Surveillance, Epidemiology, and End Results (SEER) database (1973-2010) was analyzed for all patients with dermatofibrosarcoma occurring in patients <20 years of age. Data were extracted based on age, gender, race, anatomic site, histology, stage, treatment modalities, and survival...
January 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27895450/dermatofibrosarcoma-protuberans-a-case-report-and-review-of-the-literature
#18
D Paramythiotis, G Stavrou, D Panagiotou, G Petrakis, A Michalopoulos
BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) represents less than 0.1% of all tumors, but it is considered the most common skin sarcoma. Wide local excision (=5 cm) has been largely replaced by Mohs micrographic surgery; however, recurrence is not rare. Description of the case: A 35-year-old man presented with a large tumor on the upper side of his back and underwent local excision with the possible preoperative diagnosis of lipoma. Upon histological examination, the diagnosis of DFSP was made, and the patient underwent wide local excision with skin flap reconstruction and was referred for adjuvant radiotherapy...
January 2016: Hippokratia
https://www.readbyqxmd.com/read/27879515/atypical-spindle-cell-lipomatous-tumor-clinicopathologic-characterization-of-232-cases-demonstrating-a-morphologic-spectrum
#19
Adrian Mariño-Enriquez, Alessandra F Nascimento, Azra H Ligon, Cherwei Liang, Christopher D M Fletcher
The classification of atypical adipocytic neoplasms with spindle cell features remains challenging. To better define this category of low-grade lipomatous neoplasms, we present herein the clinical, histologic, and immunohistochemical characteristics of a large series of 232 atypical spindle cell lipomatous tumors. The lesions affected 140 males and 92 females, at an average age of 54 years (range, 6 to 87 y), clinically presenting as a persistent or enlarging mass with a median size of 5 cm. The anatomic distribution of the tumors was wide, predominating in the limbs and limb girdles (147 cases, 63%), mainly in the hands and feet (17% and 11%, respectively), with equal distribution between subcutaneous and deeper locations...
February 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27806849/dermatofibrosarcoma-protuberans-pathology-genetics-and-potential-therapeutic-strategies
#20
Khin Thway, Jonathan Noujaim, Robin L Jones, Cyril Fisher
Dermatofibrosarcoma protuberans (DFSP), the most common dermal sarcoma, is a malignant fibroblastic tumor most frequently arising in middle-aged adults. It is typically a low-grade sarcoma that grows slowly but has a high rate of local recurrence with low metastatic potential. Dermatofibrosarcoma protuberans is characterized by a specific translocation t(17;22)(q22;q13) leading to the formation of COL1A1-PDGFB fusion transcripts. Histologically, DFSP has characteristic morphology, of storiform islands of bland spindle cells, and immunohistochemically, it shows diffuse expression of CD34...
December 2016: Annals of Diagnostic Pathology
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