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Adenosquamous carcinoma

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https://www.readbyqxmd.com/read/29224275/-clinicopathologic-study-of-infiltrating-epitheliosis-of-the-breast
#1
X L Xu, X Y Tu, R H Shui, Y F Cheng, B H Yu, W T Yang
Objective: To evaluate the morphological and immunohistochemical features of infiltrating epitheliosis and its differential diagnosis. Methods: Nine consultation and routine cases of infiltrating epitheliosis diagnosed from January 2015 to December 2016 in Fudan University Shanghai Cancer Center were collected. All tissues were formalin-fixed paraffin-embedded and routinely HE stained. The HE slides were reviewed. Immunohistochemical staining of CKpan, CK7, CK19, CK5/6, CK14, p63, SMMHC, Calponin, ER, PR, HER2, Ki-67 and S-100 protein was performed using Ventana BenchMark automated immunostainer...
December 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29221165/angiogenesis-in-adenosquamous-cancer-of-pancreas
#2
Nicola Silvestris, Katia Danza, Vito Longo, Oronzo Brunetti, Livia Fucci, Antonella Argentiero, Angela Calabrese, Ivana Cataldo, Roberto Tamma, Domenico Ribatti, Stefania Tommasi
Adenosquamous carcinoma of the pancreas (ASCP) is an uncommon variant of exocrine pancreatic malignancies, characterized by a histological admixture of adenomatous and squamous cell elements. This cancer is characterized by a poorly differentiated histology and a poorer clinical outcome compared to pancreatic ductal adenocarcinoma (PDAC). Unlike PDAC, that is characterized by a low microvascular density (MVD) and collapsed vasculature, no data are available about angiogenesis in ASPC. Immunohistochemical evaluation of MVD and trypatse-positive mast cells (MCs) were performed on a single case of ASCP compared to PDAC...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207712/role-of-her-2-neu-in-premalignant-and-malignant-lesions-of-uterine-cervix
#3
Swasti Bajpai, Seema Awasthi, Shyamoli Dutta, Ankita Mittal, Ashutosh Kumar, Faiyaz Ahmad
Introduction: In light of literature and controversy that exists in various cervical lesions, this prospective study was designed to explore the expression of Human Epidermal Growth Factor Receptor-2 (HER-2/neu) in the cervical lesions and its correlation with the histopathological grade and type of tumour. Immunohistochemistry (IHC) was performed to evaluate HER-2/neu expression as it is the most reliable method of detecting overexpression of HER-2/neu. Aim: To assess the role of HER-2/neu expression in premalignant and malignant lesions of uterine cervix...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29206664/chemoresistance-of-gastric-type-mucinous-carcinoma-of-the-uterine-cervix-a-study-of-the-sankai-gynecology-study-group
#4
Atsumi Kojima, Muneaki Shimada, Yoshiki Mikami, Shoji Nagao, Nobuhiro Takeshima, Toru Sugiyama, Norihiro Teramoto, Takako Kiyokawa, Junzo Kigawa, Ryuichiro Nishimura
OBJECTIVE: Gastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix, characterized by aggressive clinical behavior and absence of high-risk human papillomavirus. We conducted this study to evaluate the chemosensitivity of GAS compared with that of usual-type endocervical adenocarcinoma (UEA) in patients who had been enrolled in our previous study. METHODS: Of 52 patients from our previous phase 2 study (SGSG005) of neoadjuvant chemotherapy with docetaxel and carboplatin for stage IB2 to IIB nonsquamous cervical cancer, 47 (stage IB2, 12; stage IIA2, 7; stage IIB, 28) were enrolled in this study with written informed consent...
December 4, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29203990/squamous-cell-and-adenosquamous-carcinoma-of-gall-bladder-a-clinicopathological-study-of-8-cases-isolated-in-94-cancers
#5
Hanni Vasudev Gulwani, Suneeta Gupta, Sukhpreet Kaur
Adenosquamous/squamous cell carcinoma (AS/SCC) of the gall bladder is a rare histopathologic subtype that accounts for 1 to 12% of all the gall bladder carcinomas (GBC). Literature on these malignancies is limited. A retrospective analysis of 8 cases (study group) of pathologically proven AS/SCC of the gallbladder among 94 patients who underwent surgery for GBC from January 2001 to December 2014 was done. Twenty-four conventional gall bladder adenocarcinoma cases were selected as control group after matching for age and gender...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29191273/rare-tumors-and-lesions-of-the-pancreas
#6
REVIEW
John A Stauffer, Horacio J Asbun
There are a few entities that account for most solid and cystic masses of the pancreas. The pancreas harbors a wide array of diseases, including adenocarcinoma, and its variants, such as anaplastic and adenosquamous carcinoma. Other neoplasms include acinar cell carcinoma, solid pseudopapillary tumor, and sarcomas. Benign lesions include hamartomas, hemangiomas, lymphangioma, and plasmacytoma. Isolated metastases include renal cell carcinoma, melanoma, and other carcinomas. Benign inflammatory conditions, such as autoimmune pancreatitis and groove pancreatitis can also mimic solid neoplasms of the pancreas...
February 2018: Surgical Clinics of North America
https://www.readbyqxmd.com/read/29185262/mutational-analysis-of-kras-and-its-clinical-implications-in-cervical-cancer-patients
#7
Wei Jiang, Libing Xiang, Xuan Pei, Tiancong He, Xuxia Shen, Xiaohua Wu, Huijuan Yang
OBJECTIVE: The predictive and prognostic role of KRAS mutations in cervical cancer remains inconclusive. The aim of this study was to explore the clinicopathological and prognostic relevance of KRAS mutations in invasive cervical cancers (ICC). METHODS: Reverse transcription polymerase chain reaction (PCR) and Sanger sequencing were employed to detect KRAS mutations in 876 ICC patients. Quantitative real-time PCR was used to detect human papillomavirus (HPV) 16 and HPV 18...
January 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29182608/impact-of-tumour-histology-on-survival-in-advanced-cervical-carcinoma-an-nrg-oncology-gynaecologic-oncology-group-study
#8
Leigh G Seamon, James J Java, Bradley J Monk, Richard T Penson, Jubilee Brown, Robert S Mannel, Anna Oaknin, Mario M Leitao, Eric L Eisenhauer, Harry J Long, Shu Y Liao, Krishnansu S Tewari
BACKGROUND: Based primarily on studies concerning early-stage tumours (treated surgically), and locally advanced disease (treated with chemoradiation), the prognosis for women with adenocarcinoma (AC) or adenosquamous (AS) carcinoma has been reported to be poorer than those with squamous cell carcinoma (SCCA) of the cervix. It is unclear whether differences in prognosis also persist in the setting of recurrent or metastatic disease treated using chemotherapy doublets with or without bevacizumab...
November 28, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29177379/-clinical-pathological-features-and-survival-in-young-women-with-cervical-cancer-a-retrospective-analysis-from-the-instituto-nacional-de-enfermedades-neopl%C3%A3-sicas
#9
Rossana Ruiz, Mariana Serrano, Eloy F Ruiz, Raul Mantilla, Natalia Valdivieso, Mivael Olivera, Manuel Álvarez, Luis Mas, Henry L Gomez
OBJECTIVE: To determine the clinical and histological characteristics and prognostic factors of cervical cancer (CC) in young Peruvian patients. MATERIALS AND METHODS: Retrospective analysis of patients younger than 35 years old diagnosed with CC between 2008 and 2012 in the Instituto Nacional de Enfermedades Neoplásicas. RESULTS: 449 patients had epithelial neoplasms. The main histological types were: squamous cell carcinoma (84.9%), adenocarcinoma (11...
April 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29168459/p40-thyroid-transcription-factor-1-immunohistochemistry-a-useful-panel-to-characterize-non-small-cell-lung-carcinoma-not-otherwise-specified-nsclc-nos-category
#10
Ritika Walia, Deepali Jain, Karan Madan, Mehar C Sharma, Sandeep R Mathur, Anant Mohan, Venkateswaran K Iyer, Lalit Kumar
BACKGROUND & OBJECTIVES: Accurate histopathological subtyping of non-small cell lung carcinoma (NSCLC) is essential for targeted therapeutic agents. Immunohistochemistry (IHC) is helpful in identification of different tumour subtypes. In this study two marker approaches, one each for glandular and squamous cell differentiation was applied to maximize the proportion of accurately subtyped NSCLC not otherwise specified (NOS) tumours on small biopsy samples. METHODS: Two hundred and sixty three consecutive lung biopsies of primary lung carcinoma were prospectively studied...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29146055/imp3-contributes-to-poor-prognosis-of-patients-with-metaplastic-breast-carcinoma-a-clinicopathological-study
#11
Ryuji Ohashi, Maoka Sangen, Shigeki Namimatsu, Hiroyuki Takei, Zenya Naito
Metaplastic breast carcinoma (MBC) is a rare type of tumor with heterogenous histological patterns. We investigated the immunohistochemical expression of IMP3, an oncofetal protein, in 31 MBC patients in association with histological subtypes and clinical outcomes. The cohort consisted of spindle cell carcinoma (SPC) (n=11), squamous cell carcinoma (SCC) (n=14), matrix-producing carcinoma (MPC) (n=4), carcinoma with osteocartilaginous elements (COC) (n=1), and low grade adenosquamous cell carcinoma (ASC) (n=1)...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29145336/expression-of-hormone-receptors-in-low-grade-adenosquamous-carcinoma-of-the-breast-a-case-report
#12
Hai-Bo Wu, An-Li Zhang, Wei Wang, Heng Li
RATIONALE: Low-grade adenosquamous carcinoma (LGASC) is a rare subtype of metaplastic breast carcinoma which is generally recognized as a characteristic subgroup of triple-negative breast cancers previously. However, in this study, we reported for the first time a case of LGASC with hormone receptors expression. PATIENT CONCERNS: Pathological analysis of breast tumor specimen obtained by a 42-year-old female patient was performed. Morphologically, it composed of glandular structures with scattered squamous differentiation accompanied by haphazard arrangement of spindle cell stroma...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144557/penile-warty-mucoepidermoid-carcinoma-with-features-of-stratified-mucin-producing-intraepithelial-lesion-and-invasive-stratified-mucin-producing-carcinoma
#13
Kenji Yorita, Naoto Kuroda, Takushi Naroda, Masato Tamura, Chisato Ohe, Mukul Divatia, Mahul B Amin, Antonio L Cubilla, Dimitry V Kazakov, Ondrej Hes, Michael Michal, Michal Michal
AIMS: Stratified mucin-producing intraepithelial lesion (SMILE) and invasive stratified mucin-producing carcinoma (ISMC) are recently described cervical and penile lesions. We report an unusual case of mixed variant of penile squamous cell carcinomas with warty, usual and mucoepidermoid SMILE/ISMC features. METHODS AND RESULTS: A 62-year-old Japanese man had a glans penis lesion of one and a half years duration, suggesting malignancy. Partial penectomy and left inguinal lymphadenectomy were performed...
November 16, 2017: Histopathology
https://www.readbyqxmd.com/read/29142476/clinical-and-pathological-characterization-of-epstein-barr-virus-associated-gastric-carcinomas-in-portugal
#14
Joana Ribeiro, Andreia Oliveira, Mariana Malta, Claudia Oliveira, Fernanda Silva, Ana Galaghar, Luís Pedro Afonso, Maria Cassiano Neves, Rui Medeiros, Pedro Pimentel-Nunes, Hugo Sousa
AIM: To determine the prevalence of Epstein-Barr virus (EBV)-associated gastric carcinomas in the North Region of Portugal and to study its clinicopathological characteristics. METHODS: We have performed a retrospective study including a total of 179 consecutive patients with gastric cancer (GC) submitted to gastrectomy during 2011 at the Portuguese Oncology Institute of Porto. Clinical and pathological data was collected from individual clinical records and inserted on a database with unique codification...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29100434/oncogenic-driver-mutations-treatment-and-egfr-tki-resistance-in-a-caucasian-population-with-non-small-cell-lung-cancer-survival-in-clinical-practice
#15
Martin Faehling, Birgit Schwenk, Sebastian Kramberg, Robert Eckert, Anna-Lena Volckmar, Albrecht Stenzinger, Jörn Sträter
Introduction: Oncogenic driver mutations activating EGFR, ALK, or BRAF in NSCLC predict sensitivity to specific tyrosine-kinase inhibitors (TKIs). We provide data on prevalence, treatment and survival of driver-mutation positive NSCLC in a predominantly Caucasian population in routine clinical practice. Patients and Methods: NSCLC patients diagnosed from 2006-2015 with an EGFR-test result were included (n=265). Testing for EGFR, ALK, or BRAF was performed if specific TKI therapy was considered...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29077701/histology-as-prognostic-factor-in-early-stage-cervical-carcinoma-experience-in-a-third-level-institution
#16
Salim Abraham Barquet-Muñoz, Efraín Cruz-Rodríguez, David Francisco Cantú De León, David Isla-Ortiz, Gonzalo Montalvo-Esquivel, Luis Alonso Herrera-Montalvo, Carlos Pérez-Plasencia, Delia Pérez-Montiel, Ángel Herrera-Gómez
BACKGROUND: Cervical carcinoma (CC) is one of the most frequent neoplasms, especially in developing countries. The most common histopathological type is squamous cell carcinoma (SCC), followed by adenocarcinoma (AC) and adenosquamous carcinoma (ASC). Prognosis according to histological type is controversial. OBJECTIVE: The objective of this study is to describe and compare the prognoses of the most common histologies of CC in the early stages. MATERIALS AND METHODS: We reviewed records of patients attended at the Instituto Nacional de Cancerología of Mexico with CC surgically treated Stages IA2-IB1 and IIA1, including the histological types SCC, AC, and ASC...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29069702/a-retroperitoneal-mass-confirmed-as-a-pancreatic-adenosquamous-carcinoma-by-endoscopic-ultrasound-guided-fine-needle-aspiration
#17
César Vivian Lopes, Antônio Dal Pizzol Júnior, Karen Margarita Rico Escamilla, Antônio Atalíbio Hartmann
No abstract text is available yet for this article.
October 25, 2017: Endoscopy
https://www.readbyqxmd.com/read/29043607/ddr2-and-ifitm1-are-prognostic-markers-in-gallbladder-squamous-cell-adenosquamous-carcinomas-and-adenocarcinomas
#18
Daiqiang Li, Zhulin Yang, Ziru Liu, Qiong Zou, Yuan Yuan
This study was conducted to investigate the expressions of DDR2 and IFITM1 and their clinical and pathological significances in the rare type squamous cell/adenosquamous carcinomas (SC/ASC) and ordinary adenocarcinomas (AC) of gallbladder cancers. DDR2 and IFITM1 expression was examined in 69 SC/ASCs and 146 ACs using EnVision immunohistochemistry. Results showed that the percentage of positive DDR2 and IFITM1 expression was significantly higher in SC/ASC patients with high TNM stage, lymph node metastasis, invasion, and no resection surgery compared to patients with low TNM stages, no lymph node metastasis, no invasion, and resection surgery (P < 0...
October 17, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29038406/-results-of-partial-atrial-resection-in-advanced-lung-cancer
#19
Yoshio Tsunezuka, Nobuhiro Tanaka, Hideki Fujimori, Isao Matsumoto, Junzo Shimizu
The present study analyzed double centers experiences with extended combined resection of the left atrium in patients with lung cancer. From January 1972 to May 2017, 32 patients underwent lung resection with partial resection of the left atrium for lung cancer. Of them,( median age 62 years, range 40 to 79 years), 25 were men (78%) and 7 were women. Twenty-three pneumonectomies (72%)were performed, of which 19 (59%) were right sided. Dissection of the interatrial groove was completed in 4 patients( 36.3%)...
October 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29035716/synthesis-photophysical-and-cellular-characterisation-of-folate-and-methotrexate-labelled-luminescent-lanthanide-complexes
#20
Zhangli Du, Jing Sun, Christie A Bader, Doug A Brooks, Minqi Li, Xun Li, Sally E Plush
In this work we have developed a series of highly emissive europium(III) and terbium(III) complexes tethered to either folic acid (FA) or methotrexate (MTX), with the aim of developing visual probes that enable the imaging of folate receptors in cancer cells. The synthesis, photophysical properties and cellular behaviour are reported for four new lanthanide Ln(III) complexes, where either FA or MTX are tethered to 1,4,7-tris(carbonylmethyl)-10-(4'-quinolineacetic acid, (7'-acetamido)-1',2'-dihydro-2'-oxo)-1,4,7,10-tetraazacyclododecane Ln(III) complex, and Ln(III)=Eu(III) or Tb(III); herein referred to as Eu-FA, Eu-MTX, Tb-FA or Tb-MTX...
October 10, 2017: Journal of Inorganic Biochemistry
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