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Adenosquamous carcinoma

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https://www.readbyqxmd.com/read/28340235/polymerase-chain-reaction-human-papillomavirus-hpv-detection-and-hpv-genotyping-in-invasive-cervical-cancers-with-prior-negative-hc2-test-results
#1
Xiang Tao, Baowen Zheng, Fufen Yin, Zhengyu Zeng, Zaibo Li, Christopher C Griffith, Bing Luo, Xiangdong Ding, Xianrong Zhou, Chengquan Zhao
Objectives: Recently, three large Chinese cohort studies showed that 7.5% to 15.5% of patients with cervical carcinoma had negative high-risk human papillomavirus (hrHPV) test results on prior cytology specimens. These studies raise the question as to whether these negative hrHPV results represent truly hrHPV-negative carcinomas or false-negative hrHPV test results due to limitations in the testing of cytology specimens. This is increasingly an important question with increasing push to use hrHPV testing alone to screen for cervical cancer...
March 15, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28326512/tissue-expression-of-human-epididymal-secretory-protein-4-may-be-useful-in-the-differential-diagnosis-of-uterine-cervical-tumors
#2
Gulden Diniz, Tugba Karadeniz, Sevil Sayhan, Talya Akata, Fatma Aydiner, Duygu Ayaz, Dudu Solakoglu Kahraman, Tulay Akman
OBJECTIVES: Human Epididymal Secretory Protein 4 was firstly described as an epididymis-specific protein but more recently it has been demonstrated to be a putative serum tumor marker for different malignancies, especially ovarian epithelial cancers. The aim of this study is to investigate the association between tissue Human Epididymal Secretory Protein 4 expression and the clinicopathological features of uterine cervical tumors. MATERIAL AND METHODS: This retrospective study was designed to evaluate the differences of tissue expressions of Human Epididymal Secretory Protein 4 protein in a spectrum of cervical neoplasms...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28322191/met-gene-amplification-and-overexpression-in-chinese-non-small-cell-lung-cancer-patients-without-egfr-mutations
#3
Zhengbo Song, Xuzhou Wang, Yuhui Zheng, Haiyan Su, Yiping Zhang
BACKGROUND: The prevalence and clinical pathologic characteristics of MET amplification and overexpression in Chinese patients with non-small-cell lung cancer (NSCLC) remain unknown. In this multicenter study, we sought to reveal the frequency and clinical pathologic characteristics of MET amplification and to explore the predictive value of MET amplification and overexpression status in relation to survival in Chinese NSCLC patients. PATIENTS AND METHODS: MET amplification was detected by fluorescence in-situ hybridization in 791 patients with EGFR wild-type samples...
March 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28314688/nivolumab-treatment-for-oesophageal-squamous-cell-carcinoma-an-open-label-multicentre-phase-2-trial
#4
Toshihiro Kudo, Yasuo Hamamoto, Ken Kato, Takashi Ura, Takashi Kojima, Takahiro Tsushima, Shuichi Hironaka, Hiroki Hara, Taroh Satoh, Satoru Iwasa, Kei Muro, Hirofumi Yasui, Keiko Minashi, Kensei Yamaguchi, Atsushi Ohtsu, Yuichiro Doki, Yuko Kitagawa
BACKGROUND: Nivolumab is a human monoclonal IgG4 antibody that inhibits programmed cell death protein 1 (PD-1) expressed on activated T cells. We investigated the safety and activity of nivolumab in patients with treatment-refractory oesophageal cancer. METHODS: We did an open-label, single-arm, multicentre phase 2 study. Eligible patients had advanced squamous-cell carcinoma, adenosquamous-cell carcinoma, or adenocarcinoma of the oesophagus refractory or intolerant to fluoropyrimidine-based, platinum-based, and taxane-based chemotherapy...
March 14, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28284717/evidence-mechanism-and-clinical-relevance-of-the-transdifferentiation-from-lung-adenocarcinoma-to-squamous-cell-carcinoma
#5
REVIEW
Shenda Hou, Shiyu Zhou, Zhen Qin, Liu Yang, Xiangkun Han, Shun Yao, Hongbin Ji
Lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) are two distinct subtypes of non-small-cell lung carcinoma. Interestingly, approximately 4% to 9% of human non-small-cell lung carcinoma tumors contain mixed adenomatous and squamous pathologies in a single lesion, clinically termed adenosquamous cell carcinoma. More important, these two different pathological components frequently share identical oncogenic mutations, indicative of a potential transition. Indeed, recent data have provided convincing evidence in supporting the ADC to SCC transdifferentiation in lungs...
March 8, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28280613/clinical-characteristics-of-adenosquamous-esophageal-carcinoma
#6
Sai Yendamuri, Usha Malhotra, Mark Hennon, Austin Miller, Adrienne Groman, Alaa Halloon, Mary E Reid
BACKGROUND: Current published information of adenosquamous carcinoma (ASC) of the esophagus in the United States is limited to isolated case reports. We sought to study the clinical characteristics of this tumor using the Surveillance, Epidemiology and End Results (SEER) database. METHODS: Relevant data of all patients with esophageal cancer in the SEER database diagnosed from 1998-2010 was obtained. Demographic, grade, stage, treatment and survival characteristics of patients with ASC were summarized and compared to those patients with adenocarcinoma (ACA) and squamous cell carcinoma (SqCC)...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28230019/application-of-colon-interposition-among-the-esophageal-cancer-patients-with-partial-gastrectomy
#7
Qiuqiang Chen, Weimin Mao, Huanming Yu, Yixian Liang, Jiane Wang, Guoping Chen
BACKGROUND: Esophageal reconstruction with colon interposition is an alternative solution for the esophageal cancer patients who have partial gastrectomy. The aim of this study was to investigate the therapeutic effects of colon interposition among the esophageal carcinoma patients with partial gastrectomy. MATERIALS AND METHODS: Under institutional review board approval, 32 esophageal carcinoma patients with a history of partial gastrectomy were included in this study...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28226357/-analysis-of-clinicopathological-characteristics-and-prognosis-on-42-patients-with-primary-gastric-adenosquamous-cell-carcinoma
#8
Bin Li, Lin Sun, Xiaona Wang, Jingyu Deng, Xuewei Ding, Xuejun Wang, Bin Ke, Li Zhang, Rupeng Zhang, Han Liang
OBJECTIVE: To investigate the clinicopathological characteristics, diagnosis, treatment and prognosis of patients with primary gastric adenosquamous cell carcinoma. METHODS: A total of 5 562 patients with gastric neoplasm were admitted in Tianjin Medical University Cancer Institute and Hospital from January 2001 to January 2011. Among them 42 patients were diagnosed as primary gastric adenosquamous cell carcinoma, accounting for 0.76% of all the patients. The clinicopathological and follow-up data of these 42 patients with primary gastric adenosquamous cell carcinoma were retrospectively analyzed, and Cox proportional hazard model was used to analyze the prognostic factors of gastric adenocarcinoma squamous cell carcinoma...
February 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28219201/-precision-medical-treatment-of-non-adenocarcinoma-nsclc-patients-with-egfr-mutation
#9
Z H Wang, X Y Song
EGFR tyrosine kinase inhibitors (TKIs) treatment has been established as standard therapy for EGFR-mutated adenocarcinomas. In the studies which published prospective randomized trials comparing EGFR TKIs with chemotherapy, a very low percentage of EGFR-mutated non-adenocarcinomas was enrolled in clinical trials. The efficacy of TKIs treatment for EGFR-mutated non-adenocarcinomas and their relationship with clinicopathological characteristics remain debatable. The results of retrospective studies show that the frequency of EGFR mutation is lower in non-adenocarcinoma than that of adenocarcinoma and efficacy of TKIs treatment for non-adenocarcinoma is inferior to adenocarcinoma...
February 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28203418/clinical-outcomes-of-surgically-resected-combined-small-cell-lung-cancer-a-two-institutional-experience
#10
Chao Zhang, Haitang Yang, Heng Zhao, Baoping Lang, Xiangdong Yu, Peng Xiao, Xiao Zhang
BACKGROUND: The combined small cell lung cancer (c-SCLC) was rare and its clinicopathological characteristics had not been thoroughly described. The aim of this study was to determine prognostic factors and survival in c-SCLC patients. METHODS: Clinical records of patients with c-SCLC who underwent surgery between January 2009 and December 2013 in two institutions were retrospectively reviewed. RESULTS: Ninety-seven patients were identified...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28199962/incorporation-of-the-number-of-positive-lymph-nodes-leads-to-better-prognostic-discrimination-of-node-positive-early-stage-cervical-cancer
#11
Juan Zhou, San-Gang Wu, Jia-Yuan Sun, Xu-Lin Liao, Feng-Yan Li, Huan-Xin Lin, Li-Chao Yang, Zhen-Yu He
To determine the prognostic value of the number of positive lymph nodes (LNs) in cervical cancer and further stratify patients with positive LNs into multiple risk groups based on analysis of Surveillance Epidemiology and End Results (SEER) program. Patients with cervical cancer who undergo hysterectomy and had pathologically-confirmed positive LNs after lymphadenectomy were identified using the SEER database (1988-2012). Kaplan-Meier survival methods and Cox proportional hazards regression were performed. We included 2,222 patients with the median number of removed LNs and positive LNs was 22 and 2, respectively...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28187495/differential-hpv16-variant-distribution-in-squamous-cell-carcinoma-adenocarcinoma-and-adenosquamous-cell-carcinoma
#12
S Nicolás-Párraga, L Alemany, S de Sanjosé, F X Bosch, I G Bravo
Human Papillomavirus 16 (HPV16) causes 70% of invasive cervical cancers (ICC) worldwide. Interaction between HPV16 genetic diversity, host genetics and target tissue largely determine the chances to trigger carcinogenesis. We have analyzed the differential prevalence of viral variants in 233 HPV16-monoinfected squamous (SCC), glandular (ADC) and mixed (ADSC) ICCs from four continents, assessing the contribution of geographical origin and cancer histology. We have further quantified the contribution of viral variants and cancer histology to differences in age at tumor diagnosis...
May 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28178894/adenocarcinoma-of-the-lung-metastatic-to-the-ovary-with-a-signet-ring-cell-component
#13
Giovanna Giordano, Nelly Cruz Viruel, Enrico Maria Silini, Francisco F Nogales
A nonsmoker 45-year-old woman, presented with a solid right ovarian mass. Microscopic examination revealed heterogeneous histology with tubular formations and extensive signet ring cell component that resembled the usual appearance of metastatic gastric carcinoma to the ovary. Moreover, the histology also showed solid nests of cells with a microvacuolated basophilic cytoplasm similar to those found in adenosquamous cervical carcinoma of glassy cell type. However, analysis of the patient's past history revealed a lung adenocarcinoma, diagnosed 4 years before, which prompted an immunohistochemical differential diagnosis, showing a strong expression for TTF-1 and Napsin A...
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28166144/retro-orbital-breast-cardiac-skin-and-subcutaneous-metastases-of-neuroendocrine-tumor-from-a-tail-gut-cyst-on-68ga-dotatate-pet-ct-imaging
#14
Emine Acar, Hatice Durak, Sare Kabukcuoğlu, Serap Işiksoy, Gamze Çapa Kaya
Tail gut cysts are rare congenital lesions developing from postanal primitive gut remnants. They are mostly benign but carry a potential of malignant transformation, such as adenocarcinoma, neuroendocrine tumor, adenosquamous carcinoma, and pseudomyxoma peritonei. We present a 39-year-old woman with a neuroendocrine tumor arising within a tail gut cyst. She underwent complete resection in 2011. After 4 years, she was admitted with breast nodules, left proptosis, and gaze difficulties. Ga-DOTATATE PET/CT demonstrated extensive metastases including pelvic, lymph node, adrenal gland, bone, retro-orbital, cardiac, breast, skin, and subcutaneous metastases...
February 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28154768/warty-carcinoma-penis-an-uncommon-variant
#15
Sushma Thapa, Arnab Ghosh, Santosh Shrestha, Dilasma Ghartimagar, Raghavan Narasimhan, O P Talwar
Penile carcinoma frequency varies widely in different parts of the world and comprises 1-10% of all the malignancies in males. Majority of the cases of penile carcinoma are squamous cell carcinoma of penis comprising 60% to 70% of all cases. Warty carcinoma of penis is an unusual neoplasm and a variant of penile squamous cell carcinoma comprising 5%-10% of all the variants. The other histological variants include basaloid, verrucous, papillary, sarcomatous, mixed, and adenosquamous carcinoma. The various histological entities with an exophytic papillary lesions including warty carcinoma are together referred to as the "verruciform" group of neoplasms...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28153131/laryngeal-dysplasia-squamous-cell-carcinoma-and-variants
#16
REVIEW
Lester D R Thompson
Squamous cell carcinoma (SCC) is a malignant epithelial tumor showing evidence of squamous differentiation. It is the most common malignancy of the larynx, with several variants (verrucous, exophytic or papillary, spindle-cell, basaloid, acantholytic, adenosquamous) recognized, with well-established precursor lesions. Dysplasia is now separated into only low-grade and high-grade categories. Each SCC variant has unique cytomorphologic features and histologic differential diagnoses that are important to consider, as management and outcomes are different...
March 2017: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/28141947/the-prognostic-impact-of-histological-type-on-clinical-outcomes-of-early-stage-cervical-cancer-patients-whom-have-been-treated-with-radical-surgery
#17
Nutthaporn Chandeying, Jitti Hanprasertpong
The aim of this study was to determine the prognostic impact of histological type among squamous cell carcinoma (SCC), adenocarcinoma (AC) and adenosquamous carcinoma (ASC) on the treatment outcome of early-stage cervical cancer patients after radical hysterectomy. The cohort comprised of 626 patients, diagnosed with stages IA2-IB1 cervical cancer between 1987 and 2013. Four hundred and one patients had SCC, 190 had AC and 35 had ASC. The 5-year disease-free survival (DFS) rates for AC, SCC and ASC were 89...
January 31, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28133317/-pancreatic-adenosquamous-carcinoma-that-developed-after-resection-of-ipma-in-the-pancreatic-tail
#18
Akinao Kaneta, Takao Tsuchiya, Takahiro Saito, Satoshi Otani, Fujio Ito, Junichi Miura
Pancreatic adenosquamous carcinoma coexisting with intraductal papillary mucinous neoplasm(IPMN)is extremely rare. We report a rare case of pancreatic adenosquamous carcinoma that developed after resection of intraductal papillary mucinous adenoma(IPMA). A 67-year-old man was suspected of having a pancreatic cystic lesion. MRCP demonstrated a cystic lesion measuring 25mm in the pancreatic tail, which had an enhanced nodule. We therefore diagnosed branch duct type IPMN of the pancreas. Although pancreatic juice cytology did not indicate malignancy, we performed laparoscope-assisted distal pancreatectomy...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28127432/pulmonary-micropapillary-type-adenosquamous-carcinoma-sharing-epidermal-growth-factor-receptor-mutation-in-adenocarcinoma-and-squamous-cell-carcinoma
#19
Yusuke Takanashi, Shogo Tajima, Takamitsu Hayakawa, Tsuyoshi Takahashi, Hiroshi Neyatani, Kazuhito Funai
Adenosquamous lung carcinoma (AdSqLC) has a worse prognosis than adenocarcinoma (ADC) or squamous cell carcinoma (SQCC). Micropapillary pattern in lung ADC is an additional poor prognostic factor. We describe a rare case of AdSqLC with epidermal growth factor receptor (EGFR) mutation in both the micropapillary-ADC and SQCC components, showing long-term response to gefitinib. A 60-year-old woman underwent right lower lobectomy for primary lung cancer. Histopathological examination demonstrated adenosquamous carcinoma comprising micropapillary-ADC and moderately differentiated SQCC...
September 2016: Respirology Case Reports
https://www.readbyqxmd.com/read/28123305/clinical-outcomes-of-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors-in-recurrent-adenosquamous-carcinoma-of-the-lung-after-resection
#20
Liwen Fan, Haitang Yang, Feng Yao, Yang Zhao, Haiyong Gu, Ke Han, Heng Zhao
PURPOSE: The therapeutic efficacy of targeted therapy for adenosquamous carcinoma (ASC) of the lung remains unclear and the role of epidermal growth factor receptor (EGFR) testing in patients with ASC also remains controversial. We aimed to analyze the efficacy of EGFR tyrosine kinase inhibitors (EGFR-TKIs) in ASC. METHODS: Clinical records of patients with ASC who received treatment with EGFR-TKIs between January 2006 and December 2014 at two institutions were retrospectively reviewed...
2017: OncoTargets and Therapy
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