keyword
MENU ▼
Read by QxMD icon Read
search

Adenosquamous carcinoma

keyword
https://www.readbyqxmd.com/read/29662006/hyperinsulinemia-promotes-esophageal-cancer-development-in-a-surgically-induced-duodeno-esophageal-reflux-murine-model
#1
Diletta Arcidiacono, Arben Dedja, Cinzia Giacometti, Matteo Fassan, Daniele Nucci, Simona Francia, Federico Fabris, Alice Zaramella, Emily J Gallagher, Mauro Cassaro, Massimo Rugge, Derek LeRoith, Alfredo Alberti, Stefano Realdon
Hyperinsulinemia could have a role in the growing incidence of esophageal adenocarcinoma (EAC) and its pre-cancerous lesion, Barrett's Esophagus, a possible consequence of Gastro-Esophageal Reflux Disease. Obesity is known to mediate esophageal carcinogenesis through different mechanisms including insulin-resistance leading to hyperinsulinemia, which may mediate cancer progression via the insulin/insulin-like growth factor axis. We used the hyperinsulinemic non-obese FVB/N (Friend leukemia virus B strain) MKR (muscle (M)-IGF1R-lysine (K)-arginine (R) mouse model to evaluate the exclusive role of hyperinsulinemia in the pathogenesis of EAC related to duodeno-esophageal reflux...
April 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29650926/-a-resected-case-of-adenosquamous-carcinoma-of-pancreas-that-relapsed-in-remnant-pancreas
#2
Kotaro Miura, Akishige Kanazawa, Sadatoshi Shimizu, Akihiro Murata, Shintaro Kodai, Takafumi Nishii, Katsunobu Sakurai, Akiko Tachimori, Yutaka Tamamori, Naoshi Kubo, Toru Inoue, Yukio Nishiguchi
A 70's man underwent subtotal stomach preserving pancreatoduodenectomy(SSPPD)for pancreatic head cancer. The pathological diagnosis was adenosquamous carcinoma(ASC)of the pancreas. Two months after surgery, a recurrent tumor in the remnant pancreas was confirmed with a CT scan and suspected to be ASC by endoscopic ultrasound-guided fine needle aspiration(EUS-FNA). As the recurrent lesion was limited in the pancreas, total remnant pancreatectomy(TP)was performed 4 months after SSPPD. The final pathological diagnosis was ASC...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29609906/heterogeneity-of-pd-l1-expression-among-the-different-histological-components-and-metastatic-lymph-nodes-in-patients-with-resected-lung-adenosquamous-carcinoma
#3
Yiwei Liu, Zhengwei Dong, Tao Jiang, Likun Hou, Fengying Wu, Guanghui Gao, Yayi He, Jing Zhao, Xuefei Li, Chao Zhao, Wei Zhang, Qinrui Tian, Yingying Pan, Yan Wang, Shuo Yang, Chunyan Wu, Shengxiang Ren, Caicun Zhou, Jun Zhang, Fred R Hirsch
INTRODUCTION: Programmed death-ligand 1 (PD-L1) expression using immunohistochemistry is approved by the US Food and Drug Administration to guide treatment with anti-programmed death-1/PD-L1 monoantibodies. However, intratumoral heterogeneity of PD-L1 expression and the accordance between primary and metastatic lesions remains unresolved. MATERIALS AND METHODS: PD-L1 expression was evaluated in tumor cells and tumor-infiltrating lymphocytes (TILs) of surgically resected lung adenosquamous carcinoma...
March 31, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29606937/adenosquamous-carcinoma-of-the-colon
#4
Tagore Sunkara, Megan E Caughey, Priyanka Makkar, Febin John, Vinaya Gaduputi
Overall, colorectal cancer is the third most commonly diagnosed cancer in both men and women, meaning that it is one of the more widely recognized preventable cancers. Instances of colorectal malignancies though are overwhelmingly attributable to adenocarcinoma. Colorectal cancers with components of squamous cell carcinoma represent a statistical anomaly. Here, we present the case of a 50-year-old male, who complained of abdominal pain and weight loss over a 3-month period of time. Biopsies from a colonoscopy ultimately revealed that this patient's colon cancer consisted of both adenocarcinoma and squamous cell carcinoma, representing a truly exceptional pathology finding in a patient diagnosed with a colorectal cancer...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29600835/ovarian-preservation-in-locally-advanced-cervical-cancer-undergoing-neoadjuvant-chemotherapy-and-radical-surgery-our-experience-and-analysis-of-the-literature
#5
Mauro Signorelli, Giorgio Bogani, Valentina Chiappa, Antonino Ditto, Cono Scaffa, Fabio Martinelli, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVES: The aim of this study was to estimate the rate of ovarian metastases and recurrences among patients affected by locally advanced stage cancer patients (LACC), undergoing neoadjuvant chemotherapy (NACT) and radical surgery with conservation of ovaries. METHODS: Retrospective evaluation of consecutive patients affected by LACC (stage IB2- IIB), treated by NACT followed by radical surgery at National Cancer Institute, Milan, Italy, between 1990-2015. RESULTS: Overall, 331 patients were included...
March 30, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29600360/histopathological-assessment-for-esophageal-adenocarcinoma
#6
Alfred K Lam
In the World Health Organization (WHO) classification, adenocarcinoma of esophagus comprises preinvasive type (dysplasia), adenocarcinoma, adenoid cystic carcinoma, adenosquamous carcinoma, and mucoepidermoid carcinoma. For adenocarcinoma, it is important to determine the grading of the cancer and histological variants such as signet ring adenocarcinoma. In the current day management of esophageal adenocarcinoma by neoadjuvant therapy, the histology of the cancer and the lymph nodal status may change after the therapy...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29564177/investigation-of-targetable-predictive-and-prognostic-markers-in-gallbladder-carcinoma
#7
Azfar Neyaz, Nuzhat Husain, Sameer Gupta, Swati Kumari, Aditi Arora, Namrata Puneet Awasthi, Kiran Preet Malhotra, Sanjeev Misra
Background: Gallbladder carcinoma, uncommon in most of the world, is frequent in South East Asia. It presents in advanced stages with limited therapeutic options. We investigated targetable predictive and prognostic Markers in 268 cases including 233 primary site lesions and 35 metastatic gallbladder carcinoma. Methods: EGFR, VEGF, HER2/Neu and p53 were assessed using immunohistochemistry. HER2/Neu was validated in a subset by fluorescent in situ hybridization (FISH) using tissue microarray (TMA)...
February 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29563834/adenosquamous-carcinoma-of-the-bile-duct-a-population-based-study
#8
Bao-Dong Qin, Xiao-Dong Jiao, Ling-Yan Yuan, Ke Liu, Yuan-Sheng Zang
Introduction: Adenosquamous carcinoma (ASC) of the bile duct is a rare diagnosis with poorly understood clinicopathological characteristics and disease progression, so identification of the features associated with ASC patient survival is warranted. Materials and methods: A population cohort study was performed using prospectively extracted data from the Surveillance, Epidemiology and End Results (SEER) database for patients with histological diagnoses of ASC of the bile duct from 1973 to 2013...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29558027/clinicopathological-features-of-metaplastic-breast-carcinoma
#9
Oğuz Ahmet Hasdemir, Serhat Tokgöz, Fulya Köybaşıoğlu, Harun Karabacak, Cüneyt Yücesoy, Gökşen İnanç İmamoğlu
BACKGROUND: Metaplastic carcinoma of the breast (MpBC) is defined as a group of heterogeneous malignant neoplasms that contain glandular and non-glandular components with mixed epithelial and mesenchymal differentiations. OBJECTIVES: The aim of this study was to research the clinical and pathological characteristics of MpBC determining its rank among all breast cancers. MATERIAL AND METHODS: Metaplastic carcinoma of the breast was found in 7 out of 1,164 patients who had been diagnosed with breast cancer within the period of 12 years in our hospital...
March 19, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29541218/prothymosin-%C3%AE-and-parathymosin-expression-predicts-poor-prognosis-in-squamous-and-adenosquamous-carcinomas-of-the-gallbladder
#10
Kang Chen, Li Xiong, Zhuling Yang, Shengfu Huang, Rong Zeng, Xiongying Miao
The present study aimed to investigate the expression patterns of prothymosin-α (PTMA) and parathymosin (PTMS) in patients with squamous cell carcinoma (SCC), adenosquamous cell carcinoma (ASC) and adenocarcinoma (AC) of the gallbladder, and to assess their association with the clinicopathological characteristics and prognosis of the patients. A retrospective analysis of data pertaining to patients with SCC/ASC (n=46) and AC (n=80) of the gallbladder, who were treated with surgical resection, was conducted...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29537649/high-rate-of-pik3ca-mutations-but-no-tp53-mutation-in-low-grade-adenosquamous-carcinoma-of-the-breast
#11
Guillaume Bataillon, Laetitia Fuhrmann, Elodie Girard, Emanuelle Menet, Marick Laé, Mathieu Capovilla, Isabelle Treilleux, Laurent Arnould, Frederique Penault-Llorca, Roman Rouzier, Caterina Marchiò, Ivan Bieche, Anne Vincent-Salomon
Low-grade adenosquamous carcinoma of the breast (LGASC) is a rare variant of metaplastic carcinoma characterized by a favorable outcome and histologically composed of glandular and squamous elements in a spindle cell background typically associated with a lymphocytic stromal reaction. Due to its rarity, the immunophenoptypical and genetic profile LGASC has not been sufficiently characterized. The aim of this study was to gain insight into the molecular and phenotypic characteristics of LGASC. We reviewed the clinical, morphological features and detailed the immunohistochemical characteristics of a retrospective series of 13 LGASCs...
March 14, 2018: Histopathology
https://www.readbyqxmd.com/read/29515940/pure-squamous-cell-carcinoma-of-the-gallbladder-masquerading-as-a-hepatic-mass
#12
Abhilash Perisetti, Saikiran Raghavapuram, Benjamin Tharian, Irfan Warraich, Fred Hardwicke, Rubayat Rahman, Edwin Onkendi
Gallbladder (GB) carcinomas are adenocarcinomas (AC) in the majority of cases. Adenosquamous carcinoma (ASC) and pure squamous cell carcinoma (SCC) of the gallbladder are rarely encountered and comprise 1-3% of gallbladder cancer cases.  Pure squamous cell carcinoma of the gallbladder is rarer with less than 1% of the incidence. Most of the published literature is based on case reports and case series. The survival rates of ASC and SCC of the gallbladder are significantly lower (mean of five months) compared to the AC of the gallbladder (mean survival of 11...
January 1, 2018: Curēus
https://www.readbyqxmd.com/read/29515394/successful-resection-of-g719x-positive-pleomorphic-carcinoma-after-afatinib-treatment
#13
Daisuke Nakamura, Kentaro Miura, Hirotaka Kumeda, Hiroyuki Agatsuma, Akira Hyogotani, Kazutoshi Hamanaka, Tomonobu Koizumi, Hiroshi Yamamoto, Hisashi Tamada, Ken-Ichi Ito
We report a case of pleomorphic carcinoma with exon 18 mutation (G719X) of the epidermal growth factor receptor (EGFR), which showed good response to afatinib and resulted in successful resection. To our knowledge, this is the first report on the use of afatinib for pleomorphic carcinoma followed by the surgical resection. The patient was a 59-year-old woman, who visited our hospital because chest computed tomography showed a 28 × 28-mm nodule in the left upper lobe. Bronchoscopy was performed and the histological findings of transbronchial biopsy revealed adenosquamous carcinoma positive for G719X mutation in exon 18 of the EGFR...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29514832/rare-case-of-metaplastic-breast-cancer-in-a-man
#14
Heather Katz, Hassaan Jafri, Thomas Dougherty, Yehuda Lebowicz
Metaplastic breast cancer (MBC) in men is an extremely rare entity. MBC is typically very aggressive with a poor prognosis. In men, it has only been reported three times in the literature. We report a 47-year-old man who presented with right-sided breast erythema and nipple inversion. Mammogram revealed a 2.4 cm spiculated mass. Initial pathology was inconclusive; however, right-sided simple mastectomy showed invasive metaplastic carcinoma with adenosquamous histology. He received adjuvant chemotherapy with 4 cycles of dose dense Adriamycin and cyclophosphamide followed by 12 weeks of paclitaxel and chest wall radiation...
March 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29492923/-research-progress-of-the-clinically-uncommon-gastric-carcinoma
#15
Nannan Zhang, Jingyu Deng
Gastric cancer is one of the most important diseases that endangers people's health. Beside gastric adenocarcinoma, gastric carcinoma also includes the following types: adenosquamous carcinoma, squamous carcinoma, gastric neuroendocrine tumor, gastric hepatoid adenocarcinoma, AFP-producing gastric cancer, EBV-associated gastric cancer, lymphoepithelioma-like carcinoma, undifferentiated-type gastric cancer, gastric carcinosarcoma and so on. The adenosquamous carcinoma, squamous carcinoma of stomach, gastric hepatoid adenocarcinoma, AFP-producing gastric cancer and gastric carcinosarcoma mainly occurred in old men, while the linitisplastica gastric cancer was common in young women...
February 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29492419/adenoid-squamous-cell-carcinoma-of-oral-cavity-a-case-report
#16
Chandrakala J, Sahana Srinath, Girish Giraddi, Rohit Kumar Kendole
Adenoid squamous cell carcinoma is a rare variant of squamous cell carcinoma with features of adenoid pattern. It has been reported to originate in the sun- exposed skin of the head and neck region. Although rare, there are cases documented within the oral cavity and nasopharynx. The clinical behaviour and the prognosis are variable. We report a case of adenoid squamous cell carcinoma in a 63-year-old female patient presented with a large mass in the left mandibular alveolar ridge. Histologically, the lesion showed areas of conventional squamous cell carcinoma along with atypical epithelial cells forming a glandular pattern...
March 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29487721/clinicopathological-characteristics-and-survival-outcomes-in-adenosquamous-carcinoma-of-the-lung-a-population-based-study-from-the-seer-database
#17
Jian Wang, Bi Lian, Ling Ye, Jie Hu, Yuanlin Song
Adenosquamous carcinoma (ASC) of the lung is an unusual histology type in non-small-cell lung cancers. Due to its rarity, the clinicopathological characteristics and survival outcomes of the lung ASC are incompletely understood. We used the Surveillance, Epidemiology, and End Results (SEER) database to enroll 203,208 eligible patients, including 4,245 ASC, 124,253 adenocarcinoma (ADC) and 74,710 squamous cell carcinoma (SCC) patients. To date, this is the largest cohort in a study for ASC of the lung. With regard to age, sex, race, year of diagnosis, tumor size and SEER stage, ASC was intermediate between ADC and SCC...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29474242/cervical-adenocarcinoma-a-comparison-of-the-reproducibility-of-the-world-health-organization-2003-and-2014-classifications
#18
Aylin Sar, Qiuli Duan, Moosa Khalil, Lisa M DiFrancesco, Carol Ewanowich, Alice Lytwyn, Bojana Djordjevic, Doha Itani, Sandra Lee, Martin Köbel, Sarah Glaze, Elena Park, Máire A Duggan
OBJECTIVE: The aim of the study was to compare the reproducibility of malignant glandular tumors of the uterine cervix classified per World Health Organization (WHO) 2003 and 2014. MATERIALS AND METHODS: Two pathologists reviewed 228 cases composed of adenocarcinoma in situ and 22 adenocarcinoma histotypes and selected 405 representative hematoxylin and eosin slides, which were digitally scanned. Six other pathologists (3 gynecological and 3 anatomical) independently reviewed and classified the images per both WHO classifications...
February 23, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29464048/src-is-the-primary-target-of-aripiprazole-an-atypical-antipsychotic-drug-in-its-anti-tumor-action
#19
Mi Seon Kim, Byong Chul Yoo, Woo Seok Yang, Sang Yun Han, Deok Jeong, Jun Min Song, Kyung Hee Kim, Adithan Aravinthan, Ji Hye Kim, Jong-Hoon Kim, Seung Cheol Kim, Jae Youl Cho
Aripiprazole (ARP) is an atypical anti-psychotic drug widely used to treat schizophrenia and bipolar disorder. The pharmacological effects of ARP on cancer cells are still poorly understood. In this study, anti-cancer effects of ARP on various malignant tumor cells and its molecular mechanism were further carefully examined by using cell proliferation assay, xenograft mouse model, immunoblotting analysis, migration assay, luciferase reporter gene assay, kinase assay, and overexpression strategy. Treatment with ARP induced cytotoxicity in U251 glioma cells, MKN-1 gastric adenosquamous carcinoma cells, and CT26 colon carcinoma cells...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29459809/primary-adenosquamous-cell-carcinoma-of-the-pancreas-the-use-of-endoscopic-ultrasound-guided-fine-needle-aspiration-to-establish-a-definitive-cytologic-diagnosis
#20
Diogo Turiani Hourneaux De Moura, Martin Coronel, Danielle Azevedo Chacon, Ryan Tanigawa, Dalton M Chaves, Sérgio E Matuguma, Marcos E Lera Dos Santos, José Jukemura, Eduardo Guimarâes Hourneaux De Moura
Pancreatic cancer is the second most common malignancy of the gastrointestinal tract in the US, and adenocarcinoma has been identified as the most common type of pancreatic cancer. Different types of pancreatic cancers have been classified: adenocarcinoma, ductal adenosquamous carcinoma, solid pseudopapillary tumors, endocrine neoplasms, acinar cell carcinoma, squamous cell carcinoma, cystic tumors, primary lymphoma of the pancreas, and metastatic lesions of the pancreas. Adenosquamous carcinoma is extremely rare, behave in a very aggressive way and is responsible for the 1 to 4% of the pancreatic exocrine neoplastic lesions...
October 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
keyword
keyword
50802
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"