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Adenosquamous carcinoma

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https://www.readbyqxmd.com/read/27899985/possible-role-of-thymidine-phosphorylase-in-gynecological-tumors-as-an-individualized-treatment-strategy
#1
Masako Shida, Masanori Yasuda, Mariko Fujita, Masaki Miyazawa, Hiroshi Kajiwara, Takeshi Hirasawa, Masae Ikeda, Naruaki Matsui, Toshinari Muramatsu, Mikio Mikami
Thymidine phosphorylase (TP) is structurally similar to platelet-derived endothelial cell growth factor, and it activates 5-fluorouracil (5-FU) prodrugs and also promotes angiogenesis. In the present study, the possibility of using TP expression as a biomarker for 5-FU prodrugs, and the significance of TP as an angiogenic factor, were investigated in patients with gynecological tumors. The subjects enrolled in the study were 188 patients with gynecological tumors who provided informed consent and underwent tumor resection at the Department of Obstetrics and Gynecology of Tokai University Hospital between February 2002 and January 2010...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899779/-two-resected-cases-with-superficial-basaloid-squamous-carcinoma-of-the-esophagus
#2
Mamiko Takii, Masashi Takemura, Nobuaki Kaibe, Tsutomu Ohshima, Syojirou Kikuchi, Mitsuru Sasako
We report 2 resected cases of superficial type basaloid squamous cell carcinoma of the esophagus. Case 1 is a 67-year-old man who underwent endoscopic submucosalresection for superficialel evated type esophagealcancer of the middle thoracic esophagus. Because the pathological diagnosis of the resected specimen was basaloid squamous cell carcinoma invading to the submucosal layer with lymphatic vessel invasion, esophagectomy was indicated. The resected specimens showed no tumor in the esophagus. However, metastasis was diagnosed in the dissected mediastinall ymph nodes...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27873474/spectrum-of-gallbladder-malignancies-on-fine-needle-aspiration-cytology-5-years-retrospective-single-institutional-study-with-emphasis-on-uncommon-variants
#3
Rajesh Kumar, Radhika Srinivasan, Nalini Gupta, Pranab Dey, Arvind Rajwanshi, Raje Nijhawan, Anupam Lal, Naveen Kalra
BACKGROUND: Ultrasound-guided fine-needle aspiration cytology (FNAC) is the standard modality for diagnosis of gallbladder malignant neoplasms. Adenocarcinoma is the most common malignancy; however, other types may also be encountered. The aim of this study was to perform a retrospective analysis of gallbladder malignancies diagnosed on FNAC in the last 5 years to document the cytomorphological spectrum and the variations thereof. METHODS: The records of the Department of Cytology, PGIMER were searched from July 2010 to June 2015 and all cases of gallbladder malignancies were analyzed in detail for cytomorphological characteristics...
November 22, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27872539/adenosquamous-carcinoma-of-the-duodenum-a-rare-entity
#4
Garima Daga, Prashant Kerkar
Adenosquamous carcinomas (ASC) of the duodenum are extremely rare neoplasms. They have been reported throughout gastrointestinal tract, including the gastroesophageal junction and the anal canal. Only a few cases of ASC of the small bowel and duodenum have been reported in the literature. Here in we report a case ASC of the second part of the duodenum in a 78-year-old man.
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27867543/primary-adenosquamous-carcinoma-of-the-esophagus-an-analysis-of-39-cases
#5
Peng-Zhi Ni, Yu-Shang Yang, Wei-Peng Hu, Wen-Ping Wang, Yong Yuan, Long-Qi Chen
BACKGROUND: Adenosquamous carcinoma (ASC) of the esophagus is an uncommon type of malignant esophageal neoplasm containing both squamous cell carcinoma (SCC) and adenocacinoma (AC) components. The aim of this study was to explore the clinical characteristics and prognosis of esophageal ASC. METHODS: A retrospective review of esophageal ASC patients who underwent transthoracic esophagectomy with lymphadenectomy in our hospital from July 2007 to April 2014. RESULTS: A total of 39 (1...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27831531/subareolar-sclerosing-ductal-hyperplasia-further-characterization-of-a-distinctive-clinicopathological-entity
#6
REVIEW
Esther Cheng, Timothy M D'Alfonso, Maria Arafah, Rebecca Marrero Rolon, Paula S Ginter, Syed A Hoda
Subareolar sclerosing duct hyperplasia (SSDH) remains to be fully characterized nearly 20 years after initial description. Thirty-five SSDH cases diagnosed over a 16-year period (January 2000 to December 2015) were reviewed. All patients were female (mean age = 59 years, range = 18-80) who had presented with a unilateral solitary lesion (left 22, right 13) with a mean size of 1.3 cm (range = 0.4-3.0 cm), and showed florid and papillary epithelial hyperplasia with dense sclerosis without involvement of nipple or areolar epidermis...
November 9, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27820123/genetic-diagnosis-of-an-adenosquamous-cell-carcinoma-of-the-rectum-in-a-12-year-old-child
#7
Ines Martinez Redondo, Maria C Vera Sáez-Benito, Cristina Martinez Faci, Laura Murillo Sanjuan, Carmen Rodriguez-Vigil Iturrate, Maria Angeles Carlota Calvo Escribano, Ana I Carboné Bañeres
No abstract text is available yet for this article.
November 4, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27793441/comment-on-prognostic-factors-and-adjuvant-therapy-on-survival-in-early-stage-cervical-adenocarcinoma-adenosquamous-carcinoma-after-primary-radical-surgery-a-taiwanese-gynecologic-oncology-group-tgog-study
#8
https://www.readbyqxmd.com/read/27760593/-clinicopathologic-features-and-prognostic-implications-in-72-cases-%C3%A2-with-lung-adenosquamous-carcinoma
#9
Xi Wu, Junling Li, Shulan Chen, Lei Yu, Boyan Yang
BACKGROUND: Adenosquamous carcinoma (ASC) is a rare subtype of lung cancer, it is mixed glandular and squamous cell carcinoma with a more aggressive behavior and poor prognosis than the other histologic subtypes. The aim of the study was to explore the clinicopathological characteristics and prognostic factors of ASC. METHODS: A total of 72 patients were enrolled. We investigated clinicalpathological features and prognostic factors retrospectively. RESULTS: The overall 72 ASC patients' median age was 34...
October 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27753662/the-squamous-cells-of-adenosquamous-carcinoma-ascc-of-the-prostate-might-represent-a-terminally-differentiated-quiescent-component-immunohistochemical-evidence-from-a-case-of-ascc-with-pleomorphic-giant-tumor-cells
#10
Andres M Acosta, Andre Kajdacsy-Balla, John V Groth
No abstract text is available yet for this article.
October 7, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27748889/mcm2-and-tip30-are-prognostic-markers-in-squamous-cell-adenosquamous-carcinoma-and-adenocarcinoma-of-the-gallbladder
#11
Ziru Liu, Zhulin Yang, Song Jiang, Qiong Zou, Yuan Yuan, Jinghe Li, Daiqiang Li, Lufeng Liang, Meigui Chen, Senlin Chen
The clinicopathological and biological characteristics of squamous cell/adenosquamous carcinoma (SC/ASC) of the gallbladder remain to be fully elucidated, due to the fact that it is a rare gallbladder cancer subtype. In the current study, the expression of minichromosome maintenance complex component 2 (MCM2) and HIV‑1 tat interactive protein 2 (TIP30) was measured in 46 cases of SC/ASC and 80 adenocarcinomas (AC) using immunohistochemistry. Positive MCM2 and negative TIP30 expression were significantly associated with large tumor size, high TNM stage, invasion, lymph node metastasis and lack of surgical curability in SC/ASC and AC...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27731549/worldwide-esophageal-cancer-collaboration-clinical-staging-data
#12
T W Rice, C Apperson-Hansen, L M DiPaola, M E Semple, T E M R Lerut, M B Orringer, L-Q Chen, W L Hofstetter, B M Smithers, V W Rusch, B P L Wijnhoven, K N Chen, A R Davies, X B D'Journo, K A Kesler, J D Luketich, M K Ferguson, J V Räsänen, R van Hillegersberg, W Fang, L Durand, W H Allum, I Cecconello, R J Cerfolio, M Pera, S M Griffin, R Burger, J-F Liu, M S Allen, S Law, T J Watson, G E Darling, W J Scott, A Duranceau, C E Denlinger, P H Schipper, H Ishwaran, E H Blackstone
To address uncertainty of whether clinical stage groupings (cTNM) for esophageal cancer share prognostic implications with pathologic groupings after esophagectomy alone (pTNM), we report data-simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival-for clinically staged patients from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted data using variables with standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision...
October 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27731548/worldwide-esophageal-cancer-collaboration-neoadjuvant-pathologic-staging-data
#13
T W Rice, T E M R Lerut, M B Orringer, L-Q Chen, W L Hofstetter, B M Smithers, V W Rusch, J van Lanschot, K N Chen, A R Davies, X B D'Journo, K A Kesler, J D Luketich, M K Ferguson, J V Räsänen, R van Hillegersberg, W Fang, L Durand, W H Allum, I Cecconello, R J Cerfolio, M Pera, S M Griffin, R Burger, J-F Liu, M S Allen, S Law, T J Watson, G E Darling, W J Scott, A Duranceau, C E Denlinger, P H Schipper, H Ishwaran, C Apperson-Hansen, L M DiPaola, M E Semple, E H Blackstone
To address uncertainty of whether pathologic stage groupings after neoadjuvant therapy (ypTNM) for esophageal cancer share prognostic implications with pathologic groupings after esophagectomy alone (pTNM), we report data-simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival-for pathologically staged cancers after neoadjuvant therapy from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted data using variables with standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision...
October 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27731547/worldwide-esophageal-cancer-collaboration-pathologic-staging-data
#14
T W Rice, L-Q Chen, W L Hofstetter, B M Smithers, V W Rusch, B P L Wijnhoven, K L Chen, A R Davies, X B D'Journo, K A Kesler, J D Luketich, M K Ferguson, J V Räsänen, R van Hillegersberg, W Fang, L Durand, I Cecconello, W H Allum, R J Cerfolio, M Pera, S M Griffin, R Burger, J-F Liu, M S Allen, S Law, T J Watson, G E Darling, W J Scott, A Duranceau, C E Denlinger, P H Schipper, T E M R Lerut, M B Orringer, H Ishwaran, C Apperson-Hansen, L M DiPaola, M E Semple, E H Blackstone
We report data-simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival-for patients with pathologically staged cancer of the esophagus and esophagogastric junction after resection or ablation with no preoperative therapy from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted de-identified data using standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision...
October 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27726945/reply-prognostic-factors-and-impact-of-adjuvant-therapy-on-survival-in-early-stage-cervical-adenocacinoma-and-adenosquamous-carcinoma-after-primary-radical-hysterectomy-and-pelvic-lymphadenectomy
#15
https://www.readbyqxmd.com/read/27725467/nab-paclitaxel-gemcitabine-therapy-for-adenosquamous-carcinoma-of-the-pancreas-an-autopsy-case
#16
Kunio Kataoka, Hiroshi Matsubara, Fumihiro Urano, Shozo Okamura, Matsuyoshi Maeda
A male patient aged over 60 years presented with abdominal pain. A solid lesion measuring 7cm was detected in the pancreatic body and tail, along with periaortic lymphadenopathy. Endoscopic ultrasound-guided fine-needle aspiration suggested squamous cell carcinoma. Nab-paclitaxel+gemcitabine therapy was effective;however, tumor progression was noted after the completion of the fourth course, and the patient died from the primary cancer 7 months after the initial consultation. Autopsy led to a definitive diagnosis of adenosquamous carcinoma of the pancreas...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27721632/oral-adenosquamous-carcinoma-report-of-a-rare-entity-with-a-special-insight-on-its-histochemistry
#17
Taneeru Sravya, Guttikonda Venkateswara Rao, Manchikatla Praveen Kumar, K Sudheerkanth
Adenosquamous carcinoma (ASC) of the head and neck (H and N) is an aggressive variant of squamous cell carcinoma (SCC). They are described as SCC subtype with high infiltrative capacity and also presents with dual histomorphology, having both squamous and glandular cell components. ASC of the H and N region is considered as a controversial tumor, as it is similar to salivary gland mucoepidermoid carcinoma. It has been described in a variety of body sites, including uterine cervix, lung and pancreas. ASC rarely develops in the upper aerodigestive tract, particularly in the oral cavity...
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27696488/primary-cutaneous-adenosquamous-carcinoma-of-the-penis-the-first-characterization-of-hpv-status-in-this-rare-and-diagnostically-challenging-entity-with-review-of-glandular-carcinomas-of-the-penis
#18
P S Rush, J M Shiau, B P Hibler, B J Longley, T M Downs, D D Bennett
Glandular and pseudoglandular tumors of the penile skin are extremely uncommon and can present diagnostic challenges. Primary adenosquamous carcinoma of the penis is an extremely rare tumor, composed of distinct areas of malignant squamous and glandular cells, making it a diagnostically challenging entity. The World Health Organization (WHO) recognizes several subtypes of squamous cell carcinoma (SCC), each with its own distinctive pathologic appearance, clinical associations and prognosis. Among these variants is the exceedingly uncommon adenosquamous carcinoma (ASC), representing 1%-2% of all SCC of the penis...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27677664/adjuvant-therapy-after-radical-surgery-for-stage-ib-iib-cervical-adenocarcinoma-with-risk-factors
#19
Toshiyuki Seki, Hiroshi Tanabe, Chie Nagata, Jiro Suzuki, Kayo Suzuki, Hirokuni Takano, Seiji Isonishi, Kazuhiko Ochiai, Satoshi Takakura, Aikou Okamoto
OBJECTIVE: Patients with adeno/adenosquamous carcinoma may have a poorer prognosis than patients with squamous cell carcinoma. Radiotherapy and concurrent chemoradiotherapy are used as adjuvant therapies for cervical cancer, regardless of the histological subtype. The aim of this study was to investigate the prognostic outcome of adjuvant therapy for patients with adeno/adenosquamous carcinoma with pathological risk factors. METHODS: The medical records of 135 patients with stage IB-IIB cervical cancer with squamous cell carcinoma or adeno/adenosquamous carcinoma who underwent primary surgery followed by adjuvant therapy were retrospectively reviewed...
September 27, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27671050/-analysis-of-clinical-and-pathological-characteristics-of-high-risk-hpv-negative-carcinoma-of-the-uterine-cervix
#20
Z M Li, L Q Zeng, X H Peng, L Z Mao, X L Sun, Y H Li, X P Luo
Objective: To study the clinical and pathological characteristics of HPV-negative cervical cancer patients. Methods: Retrospective analysis of 785 cervical cancer patients in Guangdong Women and Children Hospital from Jan. 2005 to Oct. 2015. By detecting high- risk HPV infection by flow-through hybridization genechip technique. Results: (1)Among 785 cases of cervical cancer, 71 cases were negative for HPV infection tested by genechip technique, accounting for 9.0%(71/785), and the relative light units/cut off(RLU/CO)ratios of these 71 cases were less than 1 by hybird capture Ⅱ(HC-Ⅱ)methods...
September 25, 2016: Zhonghua Fu Chan Ke za Zhi
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