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Malignant fibrous histiocytoma

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https://www.readbyqxmd.com/read/28648942/dedifferentiated-chondrosarcoma-of-bone-with-prominent-rhabdoid-component
#1
Matthew Stemm, Chad Beck, Rajeev Mannem, John Neilson, Michael J Klein
Dedifferentiated chondrosarcomas (DDCS) are rare lesions, defined as tumors having a low-grade chondrosarcomatous component with an abrupt transition to a high-grade sarcoma. Although "malignant fibrous histiocytoma" (undifferentiated pleomorphic sarcoma) is the most common high grade saromatous component, many different types of sarcoma have been described. We present a case of dedifferentiated chondrosarcoma with rhabdomyosarcomatous differentiation harboring a prominent rhabdoid tumor component. To our knowledge, rhabdoid morphology in dedifferentiated chondrosarcoma has not been described in the English-language literature...
June 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28630843/osteosarcoma-of-jaw-with-varying-histomorphologic-patterns-case-report
#2
Ruchika Ravi Agrawal, Jyoti Dilip Bhavthankar, Mandakini Subhash Mandale, Purva Prakash Patil
INTRODUCTION: Osteosarcoma is a malignant mesenchymal tumor whose cancerous cells produce osteoid matrix. It is a common primary malignant bone tumor, representing 23% of total head and neck malignancies. Osteosarcomas of the jaws are rare lesions, representing only 4-7% of all osteosarcomas. This presentation discusses the clinical, radiographical, and histopathological features of a case of osteosarcoma of the mandible with unusual histopathological appearance. CASE REPORT: A 21-year-old male patient reported with a diffuse swelling of the right side of mandible with dull ache and increasing difficulties with eating and speech...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28609714/mfhas1-suppresses-tlr4-signaling-pathway-via-induction-of-pp2a-c-subunit-cytoplasm-translocation-and-inhibition-of-c-jun-dephosphorylation-at-thr239
#3
Qiqing Shi, Bo Xiong, Jing Zhong, Huihui Wang, Duan Ma, Changhong Miao
TLR4, an important Toll-like receptor in innate immunity, can be activated by LPS and induce proinflammatory cytokines to resist invasion of pathogenic microorganism, but excessive inflammation can trigger tissue injury. Many genes negatively regulate TLR4 signaling pathway. Recent studies found that malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) suppressed the expression of cytokine IL6 in Raw264.7 cells stimulated by LPS, but the mechanisms remained unclear. This study investigated the role of MFHAS1 in TLR4 signaling pathway and the possible mechanisms implicated...
June 10, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28591058/primary-hepatic-malignant-fibrous-histiocytoma-combined-with-invasion-of-inferior-vena-cava-a-case-report-and-literature-review
#4
Yifan Tong, Hong Yu, Bo Shen, Xu Feng, Guanglan Wang, Xiujun Cai
RATIONALE: Malignant fibrous histiocytoma (MFH), primary presented in liver, was very rare and displayed a poor prognosis because of high aggression. As a few of cases had been reported merely, we shared the case of primary hepatic MFH combined with invasion of inferior vena cava (IVC). PATIENTS CONCERNS: A 69-year-old women presented with abdominal pain. DIAGNOSES: Abdominal computed tomography and magnetic resonance imaging indicated a soft mass about 5...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28544597/metastasis-of-soft-tissue-sarcomas-in-lymph-node-a-cytomorphological-study
#5
Jahnavi Gandhi, Shailee Mehta, Trupti Patel, Amisha Gami, Majal Shah, Dhaval Jetly
BACKGROUND: Soft-tissue sarcoma (STS) rarely metastasizes to lymph node compared to carcinoma. Fine-needle aspiration cytology (FNAC) carries a pivotal role in diagnosis of metastatic tumor to lymph node. This study highlights the role of FNAC in diagnosis of STS metastasis to lymph node. METHOD: A retrospective study over a period by 4 years carried out. FNAC of enlarged lymph node was performed in patients with STS. Cytology smears were examined in conjunction with clinical details...
May 24, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28536856/pathologically-benign-lymph-nodes-can-mimic-malignancy-on-imaging-in-patients-with-angiomatoid-fibrous-histiocytoma
#6
Gary A Ulaner, John H Healey, Edward A Athanasian
BACKGROUND: Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue neoplasm, and its rarity makes studying it difficult. We found that several of our patients with AFH presented with radiologically suspicious local lymph nodes that were sampled because of their imaging characteristics, but the nodes proved to be benign on pathologic evaluation. Although the frequency of this finding is unknown, it seems important for orthopaedic oncologists who care for patients with AFH to know whether suspicious-appearing associated nodes in these patients warrant aggressive management...
May 23, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28512869/patterns-of-head-and-neck-sarcoma-in-australia
#7
Roger H Woods, J Alexa Potter, Jessica L Reid, Jennie Louise, Taryn Bessen, Gelareh Farshid, Susan J Neuhaus
BACKGROUND: Sarcomas affecting the head and neck often require complex management due to the combination of anatomic, aesthetic and oncological considerations. The incidence and patterns of presentation are poorly understood and have not been reviewed in the Australian population. METHOD: This study sourced incidence and demographic data from the National Cancer Registry at the Australian Institute of Health and Welfare for the years 1982-2009 (corresponding to 97...
May 16, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28497381/deep-benign-fibrous-histiocytoma-of-the-anterior-mediastinum-mimicking-malignancy
#8
Angelica Puopolo, William Newmarch, Brian Casserly
The following report describes the case of a 43-year-old male smoker that was referred to the rapid access lung clinic with haemoptysis, chest pain, and axillary lymphadenopathy-a clinical picture that raised concern for a possible underlying malignancy. Preliminary investigations revealed elevated D-dimers, low-volume haemoptysis, and a normal chest X-ray, which lowered the index of suspicion. However, computed tomography (CT) pulmonary angiogram identified a right hilar mass, several parenchymal cysts, and a large mediastinal mass...
May 11, 2017: Lung
https://www.readbyqxmd.com/read/28493803/soft-tissue-sarcomas-of-the-abdomen-and-pelvis-radiologic-pathologic-features-part-2-uncommon-sarcomas
#9
Angela D Levy, Maria A Manning, Markku M Miettinen
Soft-tissue sarcomas occurring in the abdomen and pelvis are an uncommon but important group of malignancies. Recent changes to the World Health Organization classification of soft-tissue tumors include the movement of gastrointestinal stromal tumors (GISTs) into the soft-tissue tumor classification. GIST is the most common intraperitoneal sarcoma. Liposarcoma is the most common retroperitoneal sarcoma, and leiomyosarcoma is the second most common. GIST, liposarcoma, and leiomyosarcoma account for the majority of sarcomas encountered in the abdomen and pelvis and are discussed in part 1 of this article...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28488351/homozygous-microdeletion-of-the-eri1-and-mfhas1-genes-in-a-patient-with-intellectual-disability-limb-abnormalities-and-cardiac-malformation
#10
Nancy Choucair, Mariam Rajab, André Mégarbané, Eliane Chouery
A male child, born from consanguineous parents and having intellectual disability, short stature, dysmorphic facial features, synpolydactyly, and cardiac malformations is reported. Chromosomal microarray analysis showed that the patient presents with an 8p23.1 homozygous deletion, containing the microRNA miR-4660, the exoribonuclease 1 (ERI1), and malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) genes. The microRNA miR-4660 has no known function. MFHAS1 is an immunomodulatory protein involved in Toll-like receptor signaling, erythropoiesis, and cancer...
May 9, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28471450/ubiquitylation-of-mfhas1-by-the-ubiquitin-ligase-praja2-promotes-m1-macrophage-polarization-by-activating-jnk-and-p38-pathways
#11
Jing Zhong, Huihui Wang, Wankun Chen, Zhirong Sun, Jiawei Chen, Yajun Xu, Meilin Weng, Qiqing Shi, Duan Ma, Changhong Miao
Sepsis is a systemic inflammation caused by infection. The balance between M1-M2 macrophage polarization has an essential role in the pathogenesis of sepsis. However, the exact mechanism underlying macrophage polarization is unclear. We previously showed that levels of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) were significantly elevated in septic patients compared with those in nonseptic patients, and involved in the activation of Toll-like receptor (TLR) 2/c-Jun N-terminal kinase (JNK)/nuclear factor (NF)-κB pathway...
May 4, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28468216/a-rare-case-of-malignant-fibrous-histiocytoma-undifferentiated-high-grade-pleomorphic-sarcoma-of-malar-region
#12
Éder A Sigua-Rodriguez, Douglas Rangel Goulart, Afonso Celso de Moraes Manzano, Luciana Asprino
Malignant fibrous histiocytoma is a sarcoma with rare occurrence in the oral and maxillofacial region; surgery is the most reliable treatment. Inadequate resection of the sarcoma on the oral and maxillofacial region is associated with a high incidence of local recurrence and a poor prognosis. Only few patients of malignant fibrous histiocytoma of the malar region have been previously reported in the literature. The authors report a new patient of malignant fibrous histiocytoma on the right malar region that treated a complete tumor surgical excision without lymph node dissection...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28463156/particle-therapy-using-protons-or-carbon-ions-for-unresectable-or-incompletely-resected-bone-and-soft-tissue-sarcomas-of-the-pelvis
#13
Yusuke Demizu, Dongcun Jin, Nor Shazrina Sulaiman, Fumiko Nagano, Kazuki Terashima, Sunao Tokumaru, Takashi Akagi, Osamu Fujii, Takashi Daimon, Ryohei Sasaki, Nobukazu Fuwa, Tomoaki Okimoto
PURPOSE: To retrospectively analyze the treatment outcomes of particle therapy using protons or carbon ions for unresectable or incompletely resected bone and soft tissue sarcomas (BSTSs) of the pelvis. METHODS AND MATERIALS: From May 2005 to December 2014, 91 patients with nonmetastatic histologically proven unresectable or incompletely resected pelvic BSTSs underwent particle therapy with curative intent. The particle therapy used protons (52 patients) or carbon ions (39 patients)...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28440513/optimization-of-antitumor-treatment-conditions-for-transcutaneous-co2-application-an-in-vivo-study
#14
Takeshi Ueha, Teruya Kawamoto, Yasuo Onishi, Risa Harada, Masaya Minoda, Mitsunori Toda, Hitomi Hara, Naomasa Fukase, Masahiro Kurosaka, Ryosuke Kuroda, Toshihiro Akisue, Yoshitada Sakai
Carbon dioxide (CO2) therapy can be applied to treat a variety of disorders. We previously found that transcutaneous application of CO2 with a hydrogel decreased the tumor volume of several types of tumors and induced apoptosis via the mitochondrial pathway. However, only one condition of treatment intensity has been tested. For widespread application in clinical antitumor therapy, the conditions must be optimized. In the present study, we investigated the relationship between the duration, frequency, and treatment interval of transcutaneous CO2 application and antitumor effects in murine xenograft models...
April 20, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28417560/treatment-of-tumor-in-lymph-nodes-using-near-infrared-laser-light-activated-thermosensitive-liposome-encapsulated-doxorubicin-and-gold-nanorods
#15
Daisuke Matsuki, Oladipo Adewale, Sachiko Horie, Junnosuke Okajima, Atsuki Komiya, Oluwatobi Oluwafemi, Shigenao Maruyama, Shiro Mori, Tetsuya Kodama
Tumor metastasis to lymph nodes is an important contributory factor for cancer-related deaths despite recent developments in cancer therapy. In this study, we demonstrate that tumor in the proper axillary lymph node (PALN) of the mouse can be treated by the application of external laser light to trigger the unloading of doxorubicin (DOX) encapsulated in thermosensitive liposomes (TSLs) administered together with gold nanorods (GNRs). GNRs + DOX-TSLs were injected into a mouse lymph node containing cancer cells (malignant fibrous histiocytoma-like cells) and intranodal DOX release was activated using near-infrared (NIR) laser irradiation...
April 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28388346/malignant-fibrous-histiocytoma-masquerading-as-pyogenic-granuloma
#16
Pavindran Gounder, Minh Lam, Carl Vinciullo, Jean-Louis de Sousa
A 68-year-old gentleman presented with a lesion that resembled a pyogenic granuloma in his inferior fornix. The lesion was excised and biopsy demonstrated a proliferation of malignant spindle cells. Three weeks following initial excision, the lesion recurred and was removed via wedge excision of the eyelid. Definitive clearance was achieved through Mohs micrographic surgery. The patient received adjuvant postoperative radiotherapy and remains disease-free. This case demonstrates the need to consider sinister pathology in the setting of recurrent periocular lesions...
April 2017: Orbit
https://www.readbyqxmd.com/read/28384879/primary-sarcomas-of-thyroid-gland-series-of-three-cases-with-brief-review-of-spindle-cell-lesions-of-thyroid
#17
Amita Jain Gupta, Meeta Singh, Poonam Rani, Nita Khurana, Anurag Mishra
Primary Malignant Fibrous Histiocytoma (MFH-T) and Leiomyosarcoma (LMS-T) of the thyroid gland are extremely rare tumors. Very few cases have been reported in the literature. Both entities occur more commonly in women than men. The closest clinical and histological differential diagnosis is anaplastic carcinoma of thyroid. We present three cases of rare primary sarcomas of thyroid gland. Case-1 was a 63-year-old woman and Case-2 was a 52-year-old woman. Both of them presented with a rapidly increasing thyroid mass clinically mimicking anaplastic carcinoma (AC-T)...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28349339/an-analysis-of-tumor-and-surgery-related-factors-that-contribute-to-inadvertent-positive-margins-following-soft-tissue-sarcoma-resection
#18
Kenneth R Gundle, Sanjay Gupta, Lisa Kafchinski, Anthony M Griffin, Rita A Kandel, Brendan C Dickson, Peter W Chung, Charles N Catton, Brian O'Sullivan, Peter C Ferguson, Jay S Wunder
BACKGROUND: The risk of local recurrence (LR) after soft tissue sarcoma (STS) resection is higher in the setting of inadvertent positive margins (IPMs). This study assessed whether both tumor- and surgery-related factors contribute to IPMs, and whether tumor- versus surgery-related IPMs differ in LR or overall survival (OS). METHODS: Retrospective review of a tertiary center database identified patients with IPMs following STS resection between 1989 and 2014. Of 2234 resected STSs, 309 (13%) had positive margins; 89 (4%) were IPMs...
March 27, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28301537/dedifferentiated-chondrosarcoma-radiological-features-prognostic-factors-and-survival-statistics-in-23-patients
#19
Chenglei Liu, Yan Xi, Mei Li, Qiong Jiao, Huizhen Zhang, Qingcheng Yang, Weiwu Yao
BACKGROUND: Dedifferentiated chondrosarcoma is a rare, highly malignant tumor with a poor survival. There are many confusing issues concerning the imaging feature that can facilitate early diagnosis and the factors that might be related to outcomes. METHODS: Twenty-three patients with dedifferentiated chondrosarcoma confirmed by pathology were retrospectively reviewed from 2008 to 2015. The patients' clinical information, images from radiographs (n = 17), CT (n = 19), and MRI (n = 17), histological features, treatment and prognosis were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28264709/a-rare-presentation-of-myxofibrosarcoma-as-a-pancoast-tumor-a-case-report
#20
Vasa Jevremovic, Adnan Yousuf, Zulfiqar Hussain, Amer Abboud, Edgar G Chedrawy
BACKGROUND: Myxofibrosarcoma is an aggressive soft tissue neoplasm, classified as a variant of malignant fibrous histiocytoma. Most often, it occurs in middle to late adult life peaking in the seventh decade and involving the lower extremities (77%), trunk (12%), and retroperitoneum or mediastinum (8%). We report the first case of thoracic myxofibrosarcoma presenting as a Pancoast tumor. CASE PRESENTATION: A 48-year-old non-tobacco smoking African-American man presented with a slow-growing mass in his neck along with 11 kg weight loss over 9 months...
March 7, 2017: Journal of Medical Case Reports
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