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Malignant fibrous histiocytoma

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https://www.readbyqxmd.com/read/29451657/malignant-fibrous-histiocytoma-in-a-patient-presenting-with-urinary-system-symptoms
#1
Mustafa Resorlu, Ozan Karatag, Fatma Uysal, Muhsin Ozturk
Malignant fibrous histiocytoma is a rare tumor. It is most commonly seen in individuals between the fifth and seventh decades of life, in extremities, and less frequently in the retroperitoneum. Although its etiology is not clearly known, radiotherapy, chemical agents, previous history of surgery, trauma and fracture, and Hodgkin lymphoma have been blamed. Leiomyosarcoma, liposarcoma and rhabdomyosarcoma should be taken into account in differential diagnosis. It is seen on computed tomography as a mass lesion with irregular borders and density similar to that of the surrounding muscle tissue...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29449896/myxofibrosarcoma-primary-cultures-molecular-and-pharmacological-profile
#2
Alessandro De Vita, Federica Recine, Laura Mercatali, Giacomo Miserocchi, Chiara Liverani, Chiara Spadazzi, Roberto Casadei, Alberto Bongiovanni, Federica Pieri, Nada Riva, Dino Amadori, Toni Ibrahim
Background: Myxofibrosarcoma (MFS), formerly considered as a myxoid variant of malignant fibrous histiocytoma, is the most common sarcoma of the extremities in adults and is characterized by a high frequency of local recurrence. The clinical behavior of MFS is unpredictable and the efficacy of chemotherapy is still not well documented. Furthermore, given the relatively recent recognition of MFS as a distinct pathologic entity its cellular and molecular biology has still not been extensively studied in patient-derived preclinical models...
December 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29429159/-retroperitoneal-dedifferentiated-liposarcoma-with-rhabdomyoblastic-differentiation-a-clinicopathological-analysis
#3
L Liu, L H Wang, Y B Ren, X S Rao, S M Yang
Objective: To investigate the clinicopathological features, differential diagnosis, treatment and prognosis of dedifferentiated liposarcoma with rhabdomyoblastic differentiation. Methods: Six cases of retroperitoneal dedifferentiated liposarcoma with rhabdomyoblastic features were collected from December 2014 to August 2017 at Peking University International Hospital. The clinical manifestations, histomorphology, immunophenotype, treatment and follow-up data were analyzed, and relevant literature reviewed. Results: The six patients included two males and four females, with age range of 47 to 66 years (mean 56 years)...
February 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29404161/primary-pulmonary-malignant-fibrous-histiocytoma
#4
Tuğba Coşgun, Yelda Tezel, Mustafa Akyıl, İlker Kolbaş, Ayçım Şen, Çağatay Tezel
Malignant fibrous histiocytoma (MFH) cases are classified within the group of nonclassified sarcomas. The etiopathogenesis is unclear; however, MFH commonly develops in scar tissue and in areas exposed to radiation. MFH is the most common soft tissue sarcoma in adults and may be borne in the lungs, chest wall, mediastinum, or other tissues. Primary MFH of the lung constitutes less than 0.2% of all pulmonary neoplasms; thus, an optimal treatment strategy has not yet been elucidated. We aimed to report a case of MFH of the lung with subsequent treatment administration...
April 2017: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29371905/clinical-features-and-treatment-of-fibrous-histiocytomas-of-the-tongue-a-systematic-review
#5
REVIEW
Austin Nguyen, Adam Vaudreuil, Paul Haun, Gabriel Caponetti, Christopher Huerter
Introduction  Benign fibrous histiocytomas are common lesions of the skin that rarely affect the tongue. Such cases are available in the literature exclusively as case reports. Similarly, malignant fibrous histiocytoma, now classified as undifferentiated pleomorphic sarcoma, is exceedingly rare in the tongue and not fully understood. Objectives  This study systematically reviews the available literature discussing the clinical and pathological features of malignant and benign fibrous histiocytomas. Data Synthesis  A total of 20 cases were included in this review...
January 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29279582/histopathological-diagnoses-in-soft-tissue-tumours-an-experience-from-a-tertiary-centre-in-malaysia
#6
N D Jalaludin, N Mohd Dusa, M R Hassan, N Abd Shukor
Soft tissue tumours are a group of remarkably diverse neoplasms that frequently pose significant diagnostic challenges to general pathologists. This study aimed to compare the agreement of histopathological diagnoses between general pathologists from various referral institutes and the referred soft tissue pathologist in a tertiary centre. The common discrepancies and their causes are also presented here. A retrospective study was conducted on 243 cases of potential soft tissue tumours referred to Hospital Kuala Lumpur, Malaysia over a period of 5 years...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29225876/asymptomatic-giant-retroperitoneal-mass-detected-at-a-medical-checkup
#7
Tsutomu Takeda, Daisuke Asaoka, Yuki Fukumura, Sumio Watanabe
The differential diagnosis of retroperitoneal mass includes liposarcoma, leiomyosarcoma, malignant fibrous histiocytoma, neurofibroma, stromal tumor, teratoma, and lymphoma. Leiomyosarcoma is rare with poorer prognosis than other soft tissue sarcomas. Soft tissue sarcoma of retroperitoneal origin often remains asymptomatic until tumor enlargement, leading to diagnosis at advanced stages.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29218482/a-novel-muscle-sparing-high-thoracotomy-for-upper-thoracic-spine-resection-and-reconstruction
#8
Derek T Bernstein, Wu Zhuge, Shanda H Blackmon, Rex A W Marco
PURPOSE: High thoracotomy allows access to the anterior cervicothoracic and upper thoracic vertebrae; however, traditional techniques transect shoulder girdle muscles, leading to postoperative shoulder dysfunction. Muscle-sparing techniques diminish this concern, but often sacrifice the quality of exposure. We describe a novel muscle-sparing, high thoracotomy approach for the treatment of ventral cervicothoracic and upper thoracic spine lesions. METHODS: A novel muscle-sparing, high thoracotomy approach is described, utilizing a midline posterior incision with lateral extension from the lateral decubitus position...
December 7, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29197849/retrovesical-malignant-fibrous-histiocytoma-a-rare-tumor
#9
Shuchita Pathak, Tej Prakash Soni, Anil Kumar Gupta, Lalit Mohan Sharma
Malignant fibrous histiocytoma (MFH) originating from the retrovesical space is a very rare tumour. A 61-year-old man presented to our hospital with complaints of retention of urine and burning sensation during micturition since 6 months. CT scan abdomen showed a large retrovesical mass between the urinary bladder and rectum, measuring 11×9×12 cm, displacing the urinary bladder. Serum PSA (Prostate Specific Antigen) value was within normal range. Biopsy from retrovesical mass and immunohistochemistry was suggestive of MFH...
December 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29190690/development-of-effective-tumor-immunotherapy-using-a-novel-dendritic-cell-targeting-toll-like-receptor-ligand
#10
Nadeeka H De Silva, Takashi Akazawa, Viskam Wijewardana, Norimitsu Inoue, Maremichi Oyamada, Atsuko Ohta, Yuki Tachibana, Daluthgamage Patsy H Wijesekera, Mitsuru Kuwamura, Yasuko Nishizawa, Kazuyuki Itoh, Takeshi Izawa, Shingo Hatoya, Tetsuya Hasegawa, Jyoji Yamate, Toshio Inaba, Kikuya Sugiura
Although dendritic cell (DC)-based immunotherapy shows little toxicity, improvements should be necessary to obtain satisfactory clinical outcome. Using interferon-gamma injection along with DCs, we previously obtained significant clinical responses against small or early stage malignant tumors in dogs. However, improvement was necessary to be effective to largely developed or metastatic tumors. To obtain effective methods applicable to those tumors, we herein used a DC-targeting Toll-like receptor ligand, h11c, and examined the therapeutic effects in murine subcutaneous and visceral tumor models and also in the clinical treatment of canine cancers...
2017: PloS One
https://www.readbyqxmd.com/read/29168081/high-glucose-stimulates-expression-of-mfhas1-to-mitigate-inflammation-via-akt-ho-1-pathway-in-human-umbilical-vein-endothelial-cells
#11
Hui-Hui Wang, Peng-Fei Sun, Wan-Kun Chen, Jing Zhong, Qi-Qing Shi, Mei-Lin Weng, Duan Ma, Chang-Hong Miao
Hyperglycemia is a highly dangerous factor to various diseases, even resulting in death of people. Inflammation plays a key role in this process. The aim of this study was to explore the role of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) in high-glucose induced inflammation. Our research showed that high glucose stimulated the expression of MFHAS1, and overexpression of MFHAS1 can attenuate high-glucose induced inflammation in endothelial cells by decreasing the secretion of cytokines interleukin-1β (IL-1β), interleukin-1α (IL-1α), adhesion molecule intercellular adhesion molecule-1 (ICAM), interleukin-6 (IL-6), interleukin-8 (IL-8), and chemokine ligand 1 (CXCL-1)...
November 22, 2017: Inflammation
https://www.readbyqxmd.com/read/29075871/-soft-tissue-tumors-epidemiology-classification-and-staging
#12
L Fenzl, M Mehrmann, K Kremp, G Schneider
Benign, intermediate and malignant soft tissue tumors can be differentiated histologically. Furthermore, the tumors can be subdivided according to their linear differentiation. In the new World Health Organization (WHO) classification of soft tissue tumors from 2013 changes have been made relating to the allocation of known entities, e. g. undifferentiated sarcomas have been formed into a new subgroup and are no longer assigned to the fibrohistiocytic tumors. The term malignant fibrous histiocytoma has been replaced by the undifferentiated sarcoma...
November 2017: Der Radiologe
https://www.readbyqxmd.com/read/29068573/en-bloc-resection-and-prosthesis-implantation-to-treat-malignant-fibrous-histiocytoma-of-the-humerus
#13
Jun Sun, Ru-Ming Zhang, Yu-Xin Zheng
BACKGROUND: Malignant fibrous histiocytoma (MFH) of the bone is a rare tumor. Most studies comparing limb salvage and amputation have reported that limb salvage had no adverse effect on the long-term survival of patients. This study evaluates the oncological outcomes of limb salvage procedures that were used for 15 patients with MFH of the humerus. OBJECTIVES: The aim of this study was to assess the functional and oncological outcomes of patients with malignant fibrous histiocytoma of the humerus after en bloc resection and prosthesis implantation...
August 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29040904/malignant-fibrous-histiocytoma-in-the-right-portion-of-the-mandible-with-metastasis-in-pancreas
#14
Javier Biurrun Chamale, Marco Bruno, Facundo Mandojana, Llugdar José, Lucas Armando, Doniquian Alejandro
BACKGROUND: Malignant fibrous histiocytoma is a sarcoma of uncertain origin that can be found both in soft tissues and in bones. It is currently called undifferentiated pleomorphic sarcoma not otherwise specified and it represents a final common pathway in several tumors that are subject to the progress of dedifferentiation. Local recurrence of the tumor in the same location where it was originated occurs in 20-30% of the total number of soft tissue sarcomas. It is less frequent in limbs and more likely to recur in retroperitoneal sarcomas and in head and neck...
October 12, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29022281/isolated-limb-perfusion-and-infusion-for-extremity-soft-tissue-sarcoma-a-contemporary-systematic-review-and-meta-analysis
#15
Madalyn G Neuwirth, Yun Song, Andrew J Sinnamon, Douglas L Fraker, Jonathan S Zager, Giorgos C Karakousis
BACKGROUND: Isolated limb perfusion (ILP) and isolated limb infusion (ILI) have been variably used in recent years for the treatment of locally advanced or marginally resectable extremity soft tissue sarcomas (STSs). We performed a systematic review and meta-analysis of contemporary studies to further characterize treatment patterns and outcomes. METHODS: PubMed was queried for articles published in or after the year 2000, in the English language, with > 10 patients, and with adequate outcome data following ILP/ILI...
December 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28988458/malignant-fibrous-histiocytoma-database-review-suggests-a-favorable-prognosis-in-the-head-and-neck
#16
Robert B Borucki, David M Neskey, Eric J Lentsch
OBJECTIVE: The malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma of the head and neck. Currently, most of the data on this tumor relies on small retrospective studies. The objective of this study is to use the Surveillance, Epidemiology, and End Results (SEER) database to compare characteristics of this tumor based on location to better understand its prognosis in the head and neck region. This article represents the largest study analyzing prognosis of this tumor in the head and neck to date...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28969147/pleomorphic-hyalinizing-angiectatic-tumour-a-rare-case-report-and-discussion-of-differential-diagnosis
#17
Ambica Chalmeti, Surekha U Arakeri, Anita P Javalgi, Shefali Goyal
Pleomorphic Hyalinizing Angiectatic Tumour (PHAT) is one of the rare soft tissue tumour which is non-metastasizing. The origin of this tumour is yet uncertain. It occurs in adults as a slow growing subcutaneous mass mimicking clinically and histologically to various benign and malignant soft tissue tumours such as schwannoma, haemangioma and malignant fibrous histiocytoma. The microscopic features of this tumour include clusters of ectatic, fibrin containing, hyalinized blood vessels with pleomorphic and spindle shaped tumour cells showing intranuclear inclusions, stromal haemosiderin pigment and a variable inflammatory infiltrate...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28937382/malignant-fibrous-histiocytoma-arising-from-renal-capsule-an-extremely-rare-entity
#18
Shilpa Bairwa, Ashok Sangwaiya, Mariyam Ansari, Arpita Jindal, Sapna Singla, Ajay Yadav
Malignant fibrous histiocytoma (MFH) usually presents in the extremities or retroperitoneum. MFH arising from renal parenchyma or renal capsule is extremely rare, only few cases have been reported in literature and portend a poor prognosis. Renal MFH is differentiated from renal cell carcinoma, renal sarcoma, and sarcomatoid renal tumor only by histological and immunohistochemical studies. Since the therapeutic options for MFH are different, its early diagnosis is imperative. Herein, we report a case of a primary renal MFH in a 35-year-old male...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28937375/superficial-cd34-positive-fibroblastic-tumor-a-new-entity-case-report-and-review-of-literature
#19
Neelam Sood, Binit Kumar Khandelia
Earlier, categorized under low grade malignant fibrous histiocytoma and low grade sarcomas, 'superficial CD34 positive fibroblastic tumor', a newly proposed entity, is a low grade mesenchymal tumor of intermediate malignant potential. Morphological features include monomorphic neoplastic spindle cells arranged in a fascicular to storiform pattern along with sheets of pleomorphic epithelioid cells, and multinucleated giant cells with glassy cytoplasm. Diffuse vimentin and characteristic diffuse CD34 positivity is seen in all cases with few showing focal cytokeratin expression...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28932590/primary-pulmonary-malignant-fibrous-histiocytoma-case-report-and-literature-review
#20
Xiongfei Li, Renwang Liu, Tao Shi, Shangwen Dong, Fan Ren, Fan Yang, Dian Ren, Haiyang Fan, Sen Wei, Gang Chen, Jun Chen, Song Xu
Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma known to occur in various organs. Primary MFH arising in the lung is quite rare. Herein we report a case of a 61-year-old male with primary pulmonary MFH and explore the underlying molecular mechanisms by next-generation sequencing (NGS). Five gene mutations in TSC2, ARID1B, CDK8, KDM5C and CASP8 were detected, and the mTOR inhibitor might be an effective treatment for this patient. In addition, we reviewed the scientific literature of approximately 23 primary pulmonary MFH case reports since 1990 and summarized the clinical features and prognosis of this rare pulmonary malignant tumor...
August 2017: Journal of Thoracic Disease
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