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Malignant fibrous histiocytoma

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https://www.readbyqxmd.com/read/29661049/academic-facility-utilization-and-survival-outcomes-in-adult-head-and-neck-sarcomas-an-ncdb-analysis
#1
Richard B Cannon, Patrick S Carpenter, Dustin Boothe, Luke O Buchmann, Jason P Hunt, Shane Lloyd, Ying J Hitchcock, Jeffrey J Houlton, John R Weis, Hailey M Shepherd, Marcus M Monroe
Objectives To investigate clinicopathologic and treatment factors associated with survival in adult head and neck sarcomas in the National Cancer Database (NCDB). To analyze whether treatment settings and therapies received influence survival outcomes and to compare trends in utilization via an aggregated national data set. Study Design Prospectively gathered data. Setting NCDB. Subjects and Methods The study comprised a total of 6944 adult patients treated for a head and neck sarcoma from January 2004 to December 2013...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29538190/low-grade-malignant-fibrous-histiocytoma-originating-from-the-medial-rectus-muscle
#2
Jianhua Yan
PURPOSE: Fibrous histiocytomas (FHs) involving the orbit are uncommon. To our knowledge, here the authors report the first patient with an orbital low-grade malignant FH originating from the medial rectus muscle. METHODS: A clinical report relating clinical features as well as imaging and histopathologic findings is presented. RESULTS: A 26-year-old female presented with a left eye proptosis that had been present for 4 months. A small left exotropia was observed and ocular motility evaluation revealed a -3 adduction and -1 abduction of the left eye...
March 13, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29485437/primary-hepatic-malignant-fibrous-histiocytoma-on-pet-ct
#3
Yachao Liu, Baixuan Xu
Malignant fibrous histiocytoma is mainly presented in extremities, less commonly in posterior peritoneum, but primary presented in liver is very rare and often with a poor prognosis because of its high aggression. The features of clinical presentations and images are variable and the pre-operative diagnosis is difficult. Here, we report a primary hepatic malignant fibrous histiocytoma patient with no distant metastasis showed on pre-operative F-FDG PET/CT, however with many metastases showed on the post-operative F-FDG PET/CT...
February 27, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29484233/giant-malignant-fibrous-histiocytoma-of-the-testis
#4
Volkan Ülker, Hasan Anıl Atalay, Çağlar Çakır, Aytül Sargan
We present a case of malignant fibrous histiocytoma of the testis in a 59 year- old male who admitted to our hospital with left testicular painless mass presenting for two months. A scrotal ultrasound examination and magnetic resonance imaging revealed a 9 cm left testicular solid mass. Serum tumor markers were unremarkable. The patient underwent left radical orchiectomy. Histopathologic diagnosis was giant cell variant of malignant fibrous histiocytoma which composed of varying amounts of a mixture of spindled, rounded and osteoclastic type giant cells...
January 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29475731/-adjuvant-contact-radiotherapy-for-conjunctival-malignancies-preliminary-results-of-a-series-of-14-patients-treated-with-the-papillon-50-machine
#5
R Coquard, A M N'Guyen, T Mathis, F Josserand-Pietri, M Khodri, G Largeron, N Barbet, J D Grange
PURPOSE: To evaluate the results of an adjuvant contact irradiation using 50kV photons after resection of conjunctival malignancies. MATERIALS AND METHOD: From 2012 to 2014, 14 patients (male: nine; female: five) have been treated by contact irradiation after resection of a malignant tumor of the conjunctiva (melanoma: five patients; malignant fibrous histiocytoma: one patient; carcinoma: eight patients) The treatment was performed using the Papillon 50 machine (Ariane)...
February 20, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29457437/-clinical-application-value-of-mri-on-malignant-fibrous-histiocytoma-in-soft-tissue
#6
Wan-Li Xu, Xiao Wu, Hai-Feng Qian, Dong Liu
OBJECTIVE: To investigate imaging manifestation and clinical application of MRI on malignant fibrous histiocytoma (MFH) in soft tissue. METHODS: Imaging and pathological data of 16 patients with malignant fibrous histiocytoma (MFH) in soft tissue confirmed by surgery and pathology were retrospectively analyzed from January 2009 to August 2016. There were 9 males and 7 females, aged from 34 to 67 years old with an average of 52 years. The courses of disease ranged from 5 to 48 months with an average of 27 months...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29451657/malignant-fibrous-histiocytoma-in-a-patient-presenting-with-urinary-system-symptoms
#7
Mustafa Resorlu, Ozan Karatag, Fatma Uysal, Muhsin Ozturk
Malignant fibrous histiocytoma is a rare tumor. It is most commonly seen in individuals between the fifth and seventh decades of life, in extremities, and less frequently in the retroperitoneum. Although its etiology is not clearly known, radiotherapy, chemical agents, previous history of surgery, trauma and fracture, and Hodgkin lymphoma have been blamed. Leiomyosarcoma, liposarcoma and rhabdomyosarcoma should be taken into account in differential diagnosis. It is seen on computed tomography as a mass lesion with irregular borders and density similar to that of the surrounding muscle tissue...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29449896/myxofibrosarcoma-primary-cultures-molecular-and-pharmacological-profile
#8
Alessandro De Vita, Federica Recine, Laura Mercatali, Giacomo Miserocchi, Chiara Liverani, Chiara Spadazzi, Roberto Casadei, Alberto Bongiovanni, Federica Pieri, Nada Riva, Dino Amadori, Toni Ibrahim
Background: Myxofibrosarcoma (MFS), formerly considered as a myxoid variant of malignant fibrous histiocytoma, is the most common sarcoma of the extremities in adults and is characterized by a high frequency of local recurrence. The clinical behavior of MFS is unpredictable and the efficacy of chemotherapy is still not well documented. Furthermore, given the relatively recent recognition of MFS as a distinct pathologic entity its cellular and molecular biology has still not been extensively studied in patient-derived preclinical models...
December 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29429159/-retroperitoneal-dedifferentiated-liposarcoma-with-rhabdomyoblastic-differentiation-a-clinicopathological-analysis
#9
L Liu, L H Wang, Y B Ren, X S Rao, S M Yang
Objective: To investigate the clinicopathological features, differential diagnosis, treatment and prognosis of dedifferentiated liposarcoma with rhabdomyoblastic differentiation. Methods: Six cases of retroperitoneal dedifferentiated liposarcoma with rhabdomyoblastic features were collected from December 2014 to August 2017 at Peking University International Hospital. The clinical manifestations, histomorphology, immunophenotype, treatment and follow-up data were analyzed, and relevant literature reviewed. Results: The six patients included two males and four females, with age range of 47 to 66 years (mean 56 years)...
February 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29404161/primary-pulmonary-malignant-fibrous-histiocytoma
#10
Tuğba Coşgun, Yelda Tezel, Mustafa Akyıl, İlker Kolbaş, Ayçım Şen, Çağatay Tezel
Malignant fibrous histiocytoma (MFH) cases are classified within the group of nonclassified sarcomas. The etiopathogenesis is unclear; however, MFH commonly develops in scar tissue and in areas exposed to radiation. MFH is the most common soft tissue sarcoma in adults and may be borne in the lungs, chest wall, mediastinum, or other tissues. Primary MFH of the lung constitutes less than 0.2% of all pulmonary neoplasms; thus, an optimal treatment strategy has not yet been elucidated. We aimed to report a case of MFH of the lung with subsequent treatment administration...
April 2017: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29371905/clinical-features-and-treatment-of-fibrous-histiocytomas-of-the-tongue-a-systematic-review
#11
REVIEW
Austin Nguyen, Adam Vaudreuil, Paul Haun, Gabriel Caponetti, Christopher Huerter
Introduction  Benign fibrous histiocytomas are common lesions of the skin that rarely affect the tongue. Such cases are available in the literature exclusively as case reports. Similarly, malignant fibrous histiocytoma, now classified as undifferentiated pleomorphic sarcoma, is exceedingly rare in the tongue and not fully understood. Objectives  This study systematically reviews the available literature discussing the clinical and pathological features of malignant and benign fibrous histiocytomas. Data Synthesis  A total of 20 cases were included in this review...
January 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29279582/histopathological-diagnoses-in-soft-tissue-tumours-an-experience-from-a-tertiary-centre-in-malaysia
#12
N D Jalaludin, N Mohd Dusa, M R Hassan, N Abd Shukor
Soft tissue tumours are a group of remarkably diverse neoplasms that frequently pose significant diagnostic challenges to general pathologists. This study aimed to compare the agreement of histopathological diagnoses between general pathologists from various referral institutes and the referred soft tissue pathologist in a tertiary centre. The common discrepancies and their causes are also presented here. A retrospective study was conducted on 243 cases of potential soft tissue tumours referred to Hospital Kuala Lumpur, Malaysia over a period of 5 years...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29225876/asymptomatic-giant-retroperitoneal-mass-detected-at-a-medical-checkup
#13
Tsutomu Takeda, Daisuke Asaoka, Yuki Fukumura, Sumio Watanabe
The differential diagnosis of retroperitoneal mass includes liposarcoma, leiomyosarcoma, malignant fibrous histiocytoma, neurofibroma, stromal tumor, teratoma, and lymphoma. Leiomyosarcoma is rare with poorer prognosis than other soft tissue sarcomas. Soft tissue sarcoma of retroperitoneal origin often remains asymptomatic until tumor enlargement, leading to diagnosis at advanced stages.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29218482/a-novel-muscle-sparing-high-thoracotomy-for-upper-thoracic-spine-resection-and-reconstruction
#14
Derek T Bernstein, Wu Zhuge, Shanda H Blackmon, Rex A W Marco
PURPOSE: High thoracotomy allows access to the anterior cervicothoracic and upper thoracic vertebrae; however, traditional techniques transect shoulder girdle muscles, leading to postoperative shoulder dysfunction. Muscle-sparing techniques diminish this concern, but often sacrifice the quality of exposure. We describe a novel muscle-sparing, high thoracotomy approach for the treatment of ventral cervicothoracic and upper thoracic spine lesions. METHODS: A novel muscle-sparing, high thoracotomy approach is described, utilizing a midline posterior incision with lateral extension from the lateral decubitus position...
December 7, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29197849/retrovesical-malignant-fibrous-histiocytoma-a-rare-tumor
#15
Shuchita Pathak, Tej Prakash Soni, Anil Kumar Gupta, Lalit Mohan Sharma
Malignant fibrous histiocytoma (MFH) originating from the retrovesical space is a very rare tumour. A 61-year-old man presented to our hospital with complaints of retention of urine and burning sensation during micturition since 6 months. CT scan abdomen showed a large retrovesical mass between the urinary bladder and rectum, measuring 11×9×12 cm, displacing the urinary bladder. Serum PSA (Prostate Specific Antigen) value was within normal range. Biopsy from retrovesical mass and immunohistochemistry was suggestive of MFH...
December 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29190690/development-of-effective-tumor-immunotherapy-using-a-novel-dendritic-cell-targeting-toll-like-receptor-ligand
#16
Nadeeka H De Silva, Takashi Akazawa, Viskam Wijewardana, Norimitsu Inoue, Maremichi Oyamada, Atsuko Ohta, Yuki Tachibana, Daluthgamage Patsy H Wijesekera, Mitsuru Kuwamura, Yasuko Nishizawa, Kazuyuki Itoh, Takeshi Izawa, Shingo Hatoya, Tetsuya Hasegawa, Jyoji Yamate, Toshio Inaba, Kikuya Sugiura
Although dendritic cell (DC)-based immunotherapy shows little toxicity, improvements should be necessary to obtain satisfactory clinical outcome. Using interferon-gamma injection along with DCs, we previously obtained significant clinical responses against small or early stage malignant tumors in dogs. However, improvement was necessary to be effective to largely developed or metastatic tumors. To obtain effective methods applicable to those tumors, we herein used a DC-targeting Toll-like receptor ligand, h11c, and examined the therapeutic effects in murine subcutaneous and visceral tumor models and also in the clinical treatment of canine cancers...
2017: PloS One
https://www.readbyqxmd.com/read/29168081/high-glucose-stimulates-expression-of-mfhas1-to-mitigate-inflammation-via-akt-ho-1-pathway-in-human-umbilical-vein-endothelial-cells
#17
Hui-Hui Wang, Peng-Fei Sun, Wan-Kun Chen, Jing Zhong, Qi-Qing Shi, Mei-Lin Weng, Duan Ma, Chang-Hong Miao
Hyperglycemia is a highly dangerous factor to various diseases, even resulting in death of people. Inflammation plays a key role in this process. The aim of this study was to explore the role of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) in high-glucose induced inflammation. Our research showed that high glucose stimulated the expression of MFHAS1, and overexpression of MFHAS1 can attenuate high-glucose induced inflammation in endothelial cells by decreasing the secretion of cytokines interleukin-1β (IL-1β), interleukin-1α (IL-1α), adhesion molecule intercellular adhesion molecule-1 (ICAM), interleukin-6 (IL-6), interleukin-8 (IL-8), and chemokine ligand 1 (CXCL-1)...
November 22, 2017: Inflammation
https://www.readbyqxmd.com/read/29075871/-soft-tissue-tumors-epidemiology-classification-and-staging
#18
L Fenzl, M Mehrmann, K Kremp, G Schneider
Benign, intermediate and malignant soft tissue tumors can be differentiated histologically. Furthermore, the tumors can be subdivided according to their linear differentiation. In the new World Health Organization (WHO) classification of soft tissue tumors from 2013 changes have been made relating to the allocation of known entities, e. g. undifferentiated sarcomas have been formed into a new subgroup and are no longer assigned to the fibrohistiocytic tumors. The term malignant fibrous histiocytoma has been replaced by the undifferentiated sarcoma...
November 2017: Der Radiologe
https://www.readbyqxmd.com/read/29068573/en-bloc-resection-and-prosthesis-implantation-to-treat-malignant-fibrous-histiocytoma-of-the-humerus
#19
Jun Sun, Ru-Ming Zhang, Yu-Xin Zheng
BACKGROUND: Malignant fibrous histiocytoma (MFH) of the bone is a rare tumor. Most studies comparing limb salvage and amputation have reported that limb salvage had no adverse effect on the long-term survival of patients. This study evaluates the oncological outcomes of limb salvage procedures that were used for 15 patients with MFH of the humerus. OBJECTIVES: The aim of this study was to assess the functional and oncological outcomes of patients with malignant fibrous histiocytoma of the humerus after en bloc resection and prosthesis implantation...
August 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29040904/malignant-fibrous-histiocytoma-in-the-right-portion-of-the-mandible-with-metastasis-in-pancreas
#20
Javier Biurrun Chamale, Marco Bruno, Facundo Mandojana, Llugdar José, Lucas Armando, Doniquian Alejandro
BACKGROUND: Malignant fibrous histiocytoma is a sarcoma of uncertain origin that can be found both in soft tissues and in bones. It is currently called undifferentiated pleomorphic sarcoma not otherwise specified and it represents a final common pathway in several tumors that are subject to the progress of dedifferentiation. Local recurrence of the tumor in the same location where it was originated occurs in 20-30% of the total number of soft tissue sarcomas. It is less frequent in limbs and more likely to recur in retroperitoneal sarcomas and in head and neck...
2017: International Journal of Surgery Case Reports
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