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https://www.readbyqxmd.com/read/28228694/survey-of-primary-contact-medical-and-chiropractic-clinicians-on-self-reported-knowledge-and-recognition-of-mild-traumatic-brain-injuries-a-pilot-study
#1
David N Taylor, Frank J Ponce, Stephen J Dyess
OBJECTIVE: The purpose of this study was to assess the self-reported knowledge of concussion recognition and treatment with first-contact family medical and chiropractic practitioners by means of a pilot study of the need, construct validity, and feasibility for further investigation of mild traumatic brain injury (MTBI) knowledge base. METHODS: Two hundred forty-eight practicing chiropractic and 120 medical physicians in the south and northeastern sections of the United States were contacted by e-mail, telephone, and postal mail to answer an 18-item survey on knowledge, diagnosis, and common practice with respect to traumatic brain injury patients...
March 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/28226874/impact-of-mild-traumatic-brain-injury-on-auditory-brain-stem-dysfunction-in-mouse-model
#2
Reza M Amanipour, Robert D Frisina, Samantha A Cresoe, Teresa J Parsons, Xiaoxia Zhu, Cesario V Borlongan, Joseph P Walton, Reza M Amanipour, Robert D Frisina, Samantha A Cresoe, Teresa J Parsons, Xiaoxia Zhu, Cesario V Borlongan, Joseph P Walton, Robert D Frisina, Cesario V Borlongan, Reza M Amanipour, Xiaoxia Zhu, Samantha A Cresoe, Joseph P Walton, Teresa J Parsons
The auditory brainstem response (ABR) is an electrophysiological test that examines the functionality of the auditory nerve and brainstem. Traumatic brain injury (TBI) can be detected if prolonged peak latency is observed in ABR measurements, since latency measures the neural conduction time in the brainstem, and an increase in latency can be a sign of pathological lesion at the auditory brainstem level. The ABR is elicited by brief sounds that can be used to measure hearing sensitivity as well as temporal processing...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222567/immune-biomarkers-for-the-diagnosis-of-mild-traumatic-brain-injury
#3
Ashley B Petrone, Valerie Gionis, Richard Giersch, Taura L Barr
BACKGROUND: In 2010, there were approximately 2.2 million emergency room visits associated with traumatic brain injury (TBI), with 80 percent diagnosed as mild TBI or concussion. In addition, there are a large number of TBIs, especially mild TBIs, which go either unreported by patients or initially undiagnosed by clinicians. Our team has previously identified a panel of immune-related genes that can diagnose ischemic stroke at triage, and due to shared pathophysiological mechanisms of TBI and stroke, we hypothesized that this panel of genes may also be utilized for the diagnosis of TBI...
February 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28222560/depression-following-traumatic-brain-injury-impact-on-post-hospital-residential-rehabilitation-outcomes
#4
Frank D Lewis, Gordon J Horn
BACKGROUND: A need exists to better understand the impact of depression on functional outcomes following TBI. OBJECTIVES: To evaluate the prevalence and severity of depression among a large group of chronic TBI adults; to determine the impact of depression on outcomes of post-hospital residential rehabilitation programs; and to assess effectiveness of post-hospital residential rehabilitation programs in treating depression. METHODS: 820 adults with moderate to severe traumatic brain injury (TBI) were assigned to one of four groups based on MPAI- 4 depression ratings: (1) Not Depressed, (2) Mildly Depressed, (3) Moderately Depressed, and (4) Severely Depressed...
February 8, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28211592/a-methodology-for-assessing-deployment-trauma-and-its-consequences-in-oef-oif-ond-veterans-the-tracts-longitudinal-prospective-cohort-study
#5
Regina E McGlinchey, William P Milberg, Jennifer R Fonda, Catherine Brawn Fortier
Many US veterans of Afghanistan and Iraq have multiple physical and psychiatric problems. A major focus of research has been on determining the effects of mild Traumatic Brain Injury (mTBI), but mTBI is rarely diagnosed in the absence of co-occurring conditions such as blast exposure, post-traumatic stress disorder (PTSD), depression, substance abuse, etc. These potentially interactive psychological and physical conditions produce complex patterns of cognitive, psychological, and physical symptoms that impede civilian reintegration and complicate efficient and effective treatment planning...
February 17, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28210542/dynamic-association-between-perfusion-and-white-matter-integrity-across-time-since-injury-in-veterans-with-history-of-tbi
#6
Alexandra L Clark, Katherine J Bangen, Scott F Sorg, Dawn M Schiehser, Nicole D Evangelista, Benjamin McKenna, Thomas T Liu, Lisa Delano-Wood
OBJECTIVE: Cerebral blood flow (CBF) plays a critical role in the maintenance of neuronal integrity, and CBF alterations have been linked to deleterious white matter changes. Although both CBF and white matter microstructural alterations have been observed within the context of traumatic brain injury (TBI), the degree to which these pathological changes relate to one another and whether this association is altered by time since injury have not been examined. The current study therefore sought to clarify associations between resting CBF and white matter microstructure post-TBI...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28207508/concussion-mild-traumatic-brain-injury-related-chronic-pain-in-males-and-females-a-diagnostic-modelling-study
#7
Tatyana Mollayeva, J David Cassidy, Colin M Shapiro, Shirin Mollayeva, Angela Colantonio
Pain is an unpleasant, complex, and perceived experience that places a significant burden on patients and clinicians. Its severity may be mediated by emotion, attitude, and environmental influences, and pain may be expressed differently in males and females. Traumatic brain injury (TBI) is frequently associated with chronic pain. This diagnostic modeling study examined sex differences in the construct of chronic pain in patients with delayed recovery from concussion/mild traumatic brain injury (mTBI).Data were collected from standardized questionnaires, neuroimaging records, and comprehensive clinical assessments...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28203485/relationship-of-circulating-cxcr4-epc-with-prognosis-of-mild-traumatic-brain-injury-patients
#8
Yunpeng Lin, Lan Lan Luo, Jian Sun, Weiwei Gao, Ye Tian, Eugene Park, Andrew Baker, Jieli Chen, Rongcai Jiang, Jianning Zhang
To investigate the changes of circulating endothelial progenitor cells (EPCs) and stromal cell-derived factor-1α (SDF-1α)/CXCR4 expression in patients with mild traumatic brain injury (TBI) and the correlation between EPC level and the prognosis of mild TBI. 72 TBI patients (57 mild TBI, 15 moderate TBI patients) and 25 healthy subjects (control) were included. The number of circulating EPCs, CD34(+), and CD133(+) cells and the percentage of CXCR4(+) cells in each cell population at 1,4,7,14,21 days after TBI were counted by flow cytometer...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28196657/dopamine-release-in-the-nucleus-accumbens-is-altered-following-traumatic-brain-injury
#9
Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Barry J Hoffer, Jonathan Miller, Yu-Ching Chou, Yung-Hsiao Chiang
Mild-to-severe traumatic brain injury (TBI) is frequently associated with prolonged dysfunction of reward circuitry, including motivation and salience, which suggests alterations of dopamine (DA) processing within the core and shell of the nucleus accumbens (NAC). Using fast-scan cyclic voltammetry in a rodent model of traumatic brain injury, we found that stimulus-evoked DA release is distinct in the core and shell of the NAC, with the shell being less responsive to tonic stimulation and more sensitive to the number of pulses when phasic stimulation is applied...
February 11, 2017: Neuroscience
https://www.readbyqxmd.com/read/28195957/ecological-assessment-of-everyday-executive-functioning-at-home-and-at-school-following-childhood-traumatic-brain-injury-using-the-brief-questionnaire
#10
Mathilde Chevignard, Bernadette Kerrouche, Agata Krasny-Pacini, Aude Mariller, Emmanuelle Pineau-Chardon, Pauline Notteghem, Julie Prodhomme, Didier Le Gall, Jean-Luc Roulin, Nathalie Fournet, Arnaud Roy
OBJECTIVES: To describe dysexecutive symptoms in children with traumatic brain injury (TBI) using the Behavior Rating Inventory of Executive Function (BRIEF); to compare parent- and teacher-ratings, to analyze the differential impairment in the BRIEF subscales, and factors influencing outcome. PARTICIPANTS: Children aged 5 to 18 years 11 months, referred to a rehabilitation department following TBI. OUTCOME MEASURES: Parent- and teacher reports of the BRIEF...
February 10, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28195952/the-relations-of-cognitive-behavioral-and-physical-activity-variables-to-depression-severity-in-traumatic-brain-injury-reanalysis-of-data-from-a-randomized-controlled-trial
#11
Charles H Bombardier, Jesse R Fann, Evette J Ludman, Steven D Vannoy, Joshua R Dyer, Jason K Barber, Nancy R Temkin
OBJECTIVE: To explore the relations of cognitive, behavioral, and physical activity variables to depression severity among people with traumatic brain injury (TBI) undergoing a depression treatment trial. SETTING: Community. PARTICIPANTS: Adults (N = 88) who sustained complicated mild to severe TBI within the past 10 years, met criteria for major depressive disorder, and completed study measures. DESIGN: Randomized controlled trial...
February 10, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28195856/pharmacoepidemiologic-analyses-of-opioid-use-among-oef-oif-ond-veterans
#12
Teresa J Hudson, Jacob T Painter, Brad Martin, Mark A Austen, James S Williams, John Fortney, Mark D Sullivan, Mark E Edlund
There is a great deal of concern about opioid use in Veterans, particularly those that served in Afghanistan (OEF) and Iraq (OIF and OND). The current study provides a detailed pharmacoepidemiologic analysis of opioid use among OEF/OIF/OND Veterans from FY09 to FY12. Data from three data repositories from the Veterans Health Administration (VHA) were used to describe demographic, clinical, and medication characteristics associated with opioid use among OEF/OIF/OND Veterans and among those with TBI. Logistic regression models were used to identify risks associated with chronic opioid use in FY12...
February 11, 2017: Pain
https://www.readbyqxmd.com/read/28194558/structural-imaging-of-mild-traumatic-brain-injury-may-not-be-enough-overview-of-functional-and-metabolic-imaging-of-mild-traumatic-brain-injury
#13
REVIEW
Samuel S Shin, James W Bales, C Edward Dixon, Misun Hwang
A majority of patients with traumatic brain injury (TBI) present as mild injury with no findings on conventional clinical imaging methods. Due to this difficulty of imaging assessment on mild TBI patients, there has been much emphasis on the development of diffusion imaging modalities such as diffusion tensor imaging (DTI). However, basic science research in TBI shows that many of the functional and metabolic abnormalities in TBI may be present even in the absence of structural damage. Moreover, structural damage may be present at a microscopic and molecular level that is not detectable by structural imaging modality...
February 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28192567/development-and-internal-validation-of-a-clinical-risk-score-for-treating-children-with-mild-head-trauma-and-intracranial-injury
#14
Jacob K Greenberg, Yan Yan, Christopher R Carpenter, Angela Lumba-Brown, Martin S Keller, Jose A Pineda, Ross C Brownson, David D Limbrick
Importance: The appropriate treatment of children with mild traumatic brain injury (mTBI) and intracranial injury (ICI) on computed tomographic imaging remains unclear. Evidence-based risk assessments may improve patient safety and reduce resource use. Objective: To derive a risk score predicting the need for intensive care unit observation in children with mTBI and ICI. Design, Setting, and Participants: This retrospective analysis of the prospective Pediatric Emergency Care Applied Research Network (PECARN) head injury cohort study included patients enrolled in 25 North American emergency departments from 2004 to 2006...
February 13, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28188778/work-limitations-four-years-following-mild-traumatic-brain-injury-a-cohort-study
#15
Alice Theadom, Suzanne Barker-Collo, Kelly Jones, Michael Kahan, Braden Te Ao, Kathryn McPherson, Nicola Starkey, Valery Feigin
OBJECTIVE: To explore employment status, work limitations and productivity loss following mild traumatic brain injury (TBI). STUDY DESIGN: Inception cohort study over four years. SETTING: General community. PARTICIPANTS: 245 Adults (>16 years at the time of injury), who experienced a mild TBI and who were employed prior to their injury. INTERVENTIONS: Not applicable MAIN OUTCOME MEASURES: Details of the injury, demographic information and pre-injury employment status were collected from medical records and self-report...
February 7, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28166259/increased-risk-for-age-related-impairment-in-visual-attention-associated-with-mild-traumatic-brain-injury-evidence-from-saccadic-response-times
#16
Jamie N Hershaw, David M Barry, Mark L Ettenhofer
It was hypothesized that risk for age-related impairment in attention would be greater among those with remote history of mild TBI than individuals without history of head injury. Twenty-seven adults with remote history of mild TBI and a well-matched comparison group of 54 uninjured controls completed a computerized test of visual attention while saccadic and manual response times were recorded. Within the mild TBI group only, older age was associated with slower saccadic responses and poorer saccadic inhibition...
2017: PloS One
https://www.readbyqxmd.com/read/28162033/high-density-electroencephalographic-recordings-during-sleep-in-children-and-adolescents-with-acquired-brain-injury
#17
Anne-Laure Mouthon, Andreas Meyer-Heim, Salome Kurth, Maya Ringli, Fiona Pugin, Hubertus J A van Hedel, Reto Huber
BACKGROUND: Acquired brain injuries (ABI) such as traumatic brain injury (TBI) or stroke can result in motor, language, or cognitive impairments. Although a considerable number of studies have investigated functional recovery, underlying brain reorganization remains poorly understood. Accumulating evidence indicates that plastic processes in the brain are linked to changes in electroencephalographic (EEG) slow wave activity (SWA) during deep sleep (EEG spectral power 1-4.5 Hz). OBJECTIVE: We investigated sleep SWA in children and adolescents with ABI...
February 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28160691/subject-specific-abnormal-region-detection-in-traumatic-brain-injury-using-sparse-model-selection-on-high-dimensional-diffusion-data
#18
Matineh Shaker, Deniz Erdogmus, Jennifer Dy, Sylvain Bouix
We present a method to estimate a multivariate Gaussian distribution of diffusion tensor features in a set of brain regions based on a small sample of healthy individuals, and use this distribution to identify imaging abnormalities in subjects with mild traumatic brain injury. The multivariate model receives apriori knowledge in the form of a neighborhood graph imposed on the precision matrix, which models brain region interactions, and an additional L1 sparsity constraint. The model is then estimated using the graphical LASSO algorithm and the Mahalanobis distance of healthy and TBI subjects to the distribution mean is used to evaluate the discriminatory power of the model...
January 24, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28158951/neuronal-biomarker-ubiquitin-c-terminal-hydrolase-uch-l1-detects-traumatic-intracranial-lesions-on-ct-in-children-and-youth-with-mild-traumatic-brain-injury
#19
Linda Papa, Manoj K Mittal, Jose Ramirez, Salvatore Silvestri, Philip Giordano, Carolina F Braga, Ciara Natasha S Tan, Neema J Ameli, Marco Lopez, Crystal A Haeussler, Diego Mendez Giordano, Mark R Zonfrillo
: This study examined the performance of serum Ubiquitin C-terminal Hydrolase (UCH-L1) in detecting traumatic intracranial lesions on CT scan (+CT) in children and youth with mild and moderate TBI (MMTBI) and assessed its performance in trauma control patients without head trauma. This prospective cohort study enrolled children and youth presenting to three Level 1 Trauma Centers following blunt head trauma and a GCS 9-15 as well as trauma control patients with GCS 15 that did not have blunt head trauma...
February 3, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28156140/short-term-neurocognitive-and-symptomatic-outcomes-following-mild-traumatic-brain-injury-a-prospective-multi-centre-observational-cohort-study
#20
Benjamin M Bloom, Kathryn Kinsella, Jason Pott, Hiren C Patel, Tim Harris, Fiona Lecky, Rupert Pearse
OBJECTIVE: To determine the short-term cognitive and symptomatic outcome following mild traumatic brain injury. METHODS: Setting: Emergency Departments of two UK tertiary referral hospitals. PARTICIPANTS: Adult patients presenting to the Emergency Departments of the Royal London Hospital and Salford Royal Hospital with suspected traumatic brain injury within 24 hours and Glasgow Coma Score > 8. A non-TBI comparison group included adult patients with no head or neck injury...
February 3, 2017: Brain Injury: [BI]
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