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https://www.readbyqxmd.com/read/28529492/depression-in-men-and-women-one-year-following-traumatic-brain-injury-tbi-a-tbi-model-systems-study
#1
Sarah Lavoie, Samantha Sechrist, Nhung Quach, Reza Ehsanian, Thao Duong, Ian H Gotlib, Linda Isaac
In the general population, females experience depression at significantly higher rates than males. Individuals with traumatic brain injury (TBI) are at substantially greater risk for depression compared to the overall population. Treatment of, and recovery from, TBI can be hindered by depression; comorbid TBI and depression can lead to adverse outcomes and negatively affect multiple aspects of individuals' lives. Gender differences in depression following TBI are not well understood, and relevant empirical findings have been mixed...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28528589/traumatic-brain-injury-in-the-workplace
#2
Michael Paci, Claire Infante-Rivard, Judith Marcoux
OBJECTIVES: Work-related traumatic brain injuries (TBIs) are not well documented in the literature. Published studies mostly rely on worker databases that fail to provide clinically relevant information. Our objective is to describe the characteristics of hospitalized patients and their work-related TBI. METHODS: We used the Québec provincial trauma and TBI program databases to identify all patients with a diagnosis of work-related TBI admitted to the Montreal General Hospital, a level 1 trauma center, between 2000 and 2014...
May 22, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28527714/investigation-of-left-and-right-lateral-fluid-percussion-injury-in-c57bl6-j-mice-in-vivo-functional-consequences
#3
Lesley D Schurman, Terry L Smith, Anthony J Morales, Nancy N Lee, Thomas M Reeves, Linda L Phillips, Aron H Lichtman
Although rodent models of traumatic brain injury (TBI) reliably produce cognitive and motor disturbances, behavioral characterization resulting from left and right hemisphere injuries remains unexplored. Here we examined the functional consequences of targeting the left versus right parietal cortex in lateral fluid percussion injury, on Morris water maze (MWM) spatial memory tasks (fixed platform and reversal) and neurological motor deficits (neurological severity score and rotarod). In the MWM fixed platform task, right lateral injury produced a small delay in acquisition rate compared to left...
May 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28524120/proton-magnetic-resonance-spectroscopy-%C3%A2-h-mrs-study-of-early-traumatic-brain-injury-in-rabbits
#4
Yong Xiao, Yigang Fu, Yi Zhou, Jianguo Xia, Lina Wang, Chunhong Hu
BACKGROUND The aim of this study was to investigate the relationship between dynamic changes of cerebral metabolism and degree of trauma in rabbit models of traumatic brain injury (TBI) by using proton magnetic resonance spectroscopy (¹H-MRS). MATERIAL AND METHODS Thirty-five Chinese rabbits were randomly divided into control, mild, moderate, and severe TBI groups. ¹H-MRS was performed 1, 6, and 24 h after trauma. The concentrations of NAA, Cr, Cho, and Lac, and NAA/Cr and Cho/Cr ratios in each group, were estimated...
May 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28520686/clinical-correlates-to-assist-with-chronic-traumatic-encephalopathy-diagnosis-insights-from-a-novel-rodent-repeat-concussion-model
#5
Gretchen M Thomsen, Ara Ko, Megan Y Harada, Annie Ma, Livia Wyss, Patricia Haro, Jean-Philippe Vit, Pablo Avalos, Navpreet K Dhillon, Noell Cho, Oksana Shelest, Eric J Ley
INTRODUCTION: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repetitive head injuries. Chronic traumatic encephalopathy symptoms include changes in mood, behavior, cognition, and motor function; however, CTE is currently diagnosed only postmortem. Using a rat model of recurrent traumatic brain injury (TBI), we demonstrate rodent deficits that predict the severity of CTE-like brain pathology. METHODS: Bilateral, closed-skull, mild TBI was administered once per week to 35 wild-type rats; eight rats received two injuries (2×TBI), 27 rats received five injuries (5×TBI), and 13 rats were sham controls...
June 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28520675/the-role-of-cognitive-reserve-in-recovery-from-traumatic-brain-injury
#6
Kayla A Steward, Richard Kennedy, Thomas A Novack, Michael Crowe, Daniel C Marson, Kristen L Triebel
OBJECTIVE: To examine whether cognitive reserve (CR) attenuates the initial impact of traumatic brain injury (TBI) on cognitive performance (neural reserve) and results in faster cognitive recovery rates in the first year postinjury (neural compensation), and whether the advantage of CR differs on the basis of the severity of TBI. SETTING: Inpatient/outpatient clinics at an academic medical center. PARTICIPANTS: Adults with mild TBI (mTBI; n = 28), complicated mild TBI (cmTBI; n = 24), and moderate to severe TBI (msevTBI; n = 57), and demographically matched controls (n = 66)...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520672/sertraline-for-major-depression-during-the-year-following-traumatic-brain-injury-a-randomized-controlled-trial
#7
Jesse R Fann, Charles H Bombardier, Nancy Temkin, Peter Esselman, Catherine Warms, Jason Barber, Sureyya Dikmen
OBJECTIVE: Major depressive disorder (MDD) is common and associated with impaired functioning after traumatic brain injury (TBI). Few placebo-controlled antidepressant trials exist in this population. We evaluated the efficacy and tolerability of sertraline for MDD within 1 year of sustaining a TBI. SETTING: Level I trauma center. PARTICIPANTS: Adults with MDD within 1 year of hospitalization for complicated mild to severe TBI. DESIGN: Randomized, double-blind, placebo-controlled trial...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520668/structural-connectivity-related-to-persistent-symptoms-after-mild-tbi-in-adolescents-and-response-to-aerobic-training-preliminary-investigation
#8
Weihong Yuan, Shari L Wade, Catherine Quatman-Yates, Jason A Hugentobler, Paul J Gubanich, Brad G Kurowski
OBJECTIVE: To quantify structural connectivity abnormalities in adolescents with mild traumatic brain injury (mTBI) and to investigate connectivity changes following aerobic training using graph theory and diffusion tensor imaging tractography. SETTING: Outpatient research setting. PARTICIPANTS: Twenty-two children (age: 15.83 ± 1.77 years, 10 females) with 4 to 16 weeks of persistent symptoms after mTBI and a matched healthy comparison group...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520662/anxiety-disorders-in-adults-with-childhood-traumatic-brain-injury-evidence-of-difficulties-more-than-10-years-postinjury
#9
Michelle Albicini, Audrey McKinlay
OBJECTIVE: To explore long-term psychiatric outcomes in individuals with a history of childhood traumatic brain injury (TBI) or orthopedic injury (OI). SETTING: Hospital emergency department, medical admission records and outpatient settings. PARTICIPANTS: There were 95 males (M = 22.78 years, SD = 3.44 years) and 74 females (M = 22.27 years, SD = 3.09 years), 65 with mild TBI (M = 23.25 years, SD = 3.58 years), 61 with moderate-severe TBI (M = 22...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28512443/transcranial-direct-current-stimulation-for-post-concussion-syndrome-study-protocol-for-a-randomized-crossover-trial
#10
Robson Luis Oliveira de Amorim, André Russowsky Brunoni, Mirian Akiko Furutani de Oliveira, Ana Luiza Costa Zaninotto, Marcia Mitie Nagumo, Vinícius Monteiro de Paula Guirado, Iuri Santana Neville, Gláucia Rosana Guerra Benute, Mara Cristina Souza de Lucia, Wellingson Silva Paiva, Almir Ferreira de Andrade, Manoel Jacobsen Teixeira
BACKGROUND: Mild traumatic brain injury (MTBI) represents 70-80% of all treated brain injuries. A considerable proportion of MTBI patients experience post-concussion symptoms for a prolonged period after MTBI, and these symptoms are diagnosed as persistent post-concussion syndrome (PPCS). PPCS is defined as a range of physical, cognitive, and emotional symptoms. However, memory and executive dysfunction seems to be one of the most debilitating symptoms. Recently, non-invasive brain stimulation has been studied as a potential treatment method for traumatic brain injury (TBI) patients...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28511727/rejection-sensitivity-as-a-moderator-of-psychosocial-outcomes-following-pediatric-traumatic-brain-injury
#11
Emily A Meadows, Keith Owen Yeates, Kenneth H Rubin, H Gerry Taylor, Erin D Bigler, Maureen Dennis, Cynthia A Gerhardt, Kathryn Vannatta, Terry Stancin, Kristen R Hoskinson
OBJECTIVES: The current study examines whether psychosocial outcomes following pediatric traumatic brain injury (TBI) vary as a function of children's rejection sensitivity (RS), defined as their disposition to be hypersensitive to cues of rejection from peers. METHODS: Children ages 8-13 with a history of severe TBI (STBI, n=16), complicated mild/moderate TBI (n=35), or orthopedic injury (OI, n=49) completed measures assessing self-esteem and RS on average 3.28 years post-injury (SD=1...
May 17, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28511571/brain-injury-and-offending-the-development-and-field-testing-of-a-linkworker-intervention
#12
Sara D S Ramos, Michael Oddy, James Liddement, Deborah Fortescue
Evidence suggests that traumatic brain injury (TBI) is more prevalent amongst offender populations than in the general population, and that it can lead to aggressive behaviour while in custody and impair engagement with offender rehabilitation programmes. The aim of this study was to develop, implement, and evaluate a brain injury Linkworker approach designed to support prisoners who report a significant TBI or multiple mild TBIs. Three clinical case examples are reported to illustrate the conceptual foundations of the approach and to demonstrate the feasibility of the service...
May 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/28511279/blast-associated-traumatic-brain-injury-in-the-military-as-a-potential-trigger-for-dementia-and-chronic-traumatic-encephalopathy
#13
James Hasoon
Traumatic brain injuries (TBIs) resulting from blast exposures have significantly affected US military personnel throughout the world, particularly in Iraq and Afghanistan. From 2000-2016, more than 350,000 military service members were diagnosed with a TBI. Since the majority of blast-related TBIs are classified as mild with no definitive findings on physical examination or diagnostic studies, it is difficult to accurately diagnose individuals inflicted with such injuries. There are likely far more mild TBIs that remain undiagnosed in the military...
January 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/28508357/biofluid-proteomics-and-biomarkers-in-traumatic-brain-injury
#14
Safa Azar, Anwarul Hasan, Richard Younes, Farah Najdi, Lama Baki, Hussein Ghazale, Firas H Kobeissy, Kazem Zibara, Stefania Mondello
Traumatic brain injury (TBI) is an injury to the brain caused by an external mechanical force, affecting millions of people worldwide. The disease course and prognosis are often unpredictable, and it can be challenging to determine an early diagnosis in case of mild injury as well as to accurately phenotype the injury. There is currently no cure for TBI-drugs having failed repeatedly in clinical trials-but an intense effort has been put to identify effective neuroprotective treatment. The detection of novel biomarkers, to understand more of the disease mechanism, facilitates early diagnosis, predicts disease progression, and develops molecularly targeted therapies that would be of high clinical interest...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28507998/effects-of-pre-injury-anti-platelet-agents-on-short-term-outcome-of-patients-with-mild-traumatic-brain-injury-a-cohort-study
#15
Davood Farsi, Parviz Karimi, Mani Mofidi, Babak Mahshidfar, Mahdi Rezai, Peyman Hafezimoghadam, Saeed Abbasi
OBJECTIVE: To determine the effects of pre-injury consumption of anti-platelet agents on the 30-day outcomes of patients with mild traumatic brain injury (TBI). METHODS: This prospective cohort study was conducted at three general hospitals in Tehran, Iran between July 2013 and July 2014. The study population included all patients with mild TBI aged over 18 years that medicated with aspirin or clopidogrel before occurring trauma. Within hospitalization, all patients were assessed with respect to in-hospital conditions especially complications and adverse events...
April 2017: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/28506081/epidemiological-characteristics-of-chinese-paediatric-traumatic-brain-injury-inpatients
#16
Yunming Li, Fuqin Chen, Junran Zhang, Gang Li, Xiaoguang Yang, Qiang Lu, Xun Xia, Xinyan Zhang, Jun Qiu, Junpeng Zhang, Jihong Zhou, Yongqin Kuang, Jianwen Gu
PRIMARY OBJECTIVE: To investigate the epidemiological characteristics of paediatric inpatients with traumatic brain injury (TBI) in China. RESEARCH DESIGN: The Chinese Trauma Database (CTD), a nationwide register system based on hospital admission data, contains diagnosis and treatment information for trauma inpatients in over 200 military-managed public-service hospitals in China. Using the ICD-9 coding, the data for children with TBI aged 0-17 years between 2001 and 2007 were retrieved...
May 16, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28502689/complicated-mild-traumatic-brain-injury-and-the-need-for-imaging-surveillance
#17
Martina Stippler, Jingyi Liu, Rouzbeh Motiei-Langroudi, Zoya Voronovich, Howard Yonas, Roger B Davis
OBJECTIVE: to evaluate the need for repeat head CT in patients with complicated mild traumatic brain injury (cmTBI) determined non-operative after the first head CT METHODS: 380 patients with mild TBI and a positive head CT not needing surgery were included. Changes between first and second head CT were categorized as decreased, increased or stable. RESULTS: Three patients required neurosurgical intervention (0.8%) after the second CT. There were no significant differences in demographics including age, gender, alcohol consumption, anticoagulation status, time between first and second CT, GCS at admission and discharge, and incidence of SAH, EDH, contusion or skull fractures between the operated and non-operated groups...
May 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28499842/establishing-the-ferret-as-a-gyrencephalic-animal-model-of-traumatic-brain-injury-optimization-of-controlled-cortical-impact-procedures
#18
Susan C Schwerin, Elizabeth B Hutchinson, Kryslaine L Radomski, Kapinga P Ngalula, Carlo M Pierpaoli, Sharon L Juliano
BACKGROUND: Although rodent TBI studies provide valuable information regarding the effects of injury and recovery, an animal model with neuroanatomical characteristics closer to humans may provide a more meaningful basis for clinical translation. The ferret has a high white/gray matter ratio, gyrencephalic neocortex, and ventral hippocampal location. Furthermore, ferrets are amenable to behavioral training, have a body size compatible with pre-clinical MRI, and are cost-effective. NEW METHODS: We optimized the surgical procedure for controlled cortical impact (CCI) using 9 adult male ferrets...
May 9, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28497984/recovery-of-working-memory-following-pediatric-traumatic-brain-injury-a-longitudinal-analysis
#19
Stephanie Gorman, Marcia A Barnes, Paul R Swank, Linda Ewing-Cobbs
In a prospective longitudinal study, the trajectory of verbal and visual-spatial working memory (WM) development was examined 2-, 6-, 12-, and 24-months following complicated-mild to severe pediatric traumatic brain injury (TBI; n = 55) relative to an orthopedic injury comparison group (n = 47). Individual growth curve modeling revealed an interaction of age, severity, and time for verbal, but not visual-spatial WM. The youngest children with severe TBI had the lowest scores and slowest verbal WM growth...
May 12, 2017: Developmental Neuropsychology
https://www.readbyqxmd.com/read/28494496/sensitivity-to-binocular-disparity-is-reduced-by-mild-traumatic-brain-injury
#20
Gunnar Schmidtmann, Tatiana Ruiz, Alexandre Reynaud, Daniel P Spiegel, Maude Laguë-Beauvais, Robert F Hess, Reza Farivar
Purpose: The impairment of visual functions is one of the most common complaints following mild traumatic brain injury (mTBI). Traumatic brain injury-associated visual deficits include blurred vision, reading problems, and eye strain. In addition, previous studies have found evidence that TBI can diminish early cortical visual processing, particularly for second-order stimuli. We investigated whether cortical processing of binocular disparity is also affected by mTBI. Methods: In order to investigate the influence of mTBI on global stereopsis, we measured the quick Disparity Sensitivity Function (qDSF) in 22 patients with mTBI...
May 1, 2017: Investigative Ophthalmology & Visual Science
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