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https://www.readbyqxmd.com/read/28643992/recent-perspectives-of-molecular-aberrations-in-pediatric-high-grade-glioma
#1
Zhengwei Li, Qingzeng Sun, Yingchun Shi
Paediatric high-grade glioma (HGG), including diffuse intrinsic pontine glioma (DIPG) are highly aggressive tumours with no effective cures. Lack of understanding of the molecular biology of these tumours, in part due to lack of well-characterized pre-clinical models, is a great challenge in the development of novel therapies. Recent studies have shown that paediatric HGG short-term cell cultures retain many of the tumour characteristics in vivo and at present one of the best choices for in-vivo experimental studies...
June 22, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28643812/-conscience-clause-in-end-of-life-care
#2
Ludovica De Panfilis, Daniela Cattaneo, Luisanna Cola, Maddalena Gasparini, Corinna Porteri, Daniela Tarquini, Alessandro Tiezzi, Simone Veronese, Silvia Zullo, Eugenio Pucci
The article proposes a critical reflection on issues that appeal to the conscience clause as part of end of life care can produce and what can guarantee freedom of conscience, self-determination of those involved and respect for the dignity of the sick person. After a philosophical and normative analysis, the article is organized on the basis of two important documents for discussion: a position paper of Società Italiana di Anestesia Analgesia Rianimazione e Terapia Intensiva (SIAARTI) signed by several scientific societies "Grandi insufficienze d'organo end stage: cure intensive o cure palliative?" and the Design of Law currently being debated "Norme in materia di consenso informato e di disposizioni anticipate di trattamento"...
May 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28642922/universal-cements-dual-activated-and-chemically-activated
#3
Eliane de Lima, Ricardo Santos, Márcia Durão, Armiliana Nascimento, Rodivan Braz
Objective: The aim of the present study was to assess the bond strength of universal cements cured either dually or chemically only. Methods: Three cements were assessed using different types of application: dual activated (DA) or chemically activated (CA). In total 80 dentin blocks were used, obtained through the enamel wear of the lingual and buccal surfaces of bovine incisors. Standard cone-shaped cavity preparations were created using diamond burs. Subsequently, indirect restoration blocks were designed with Filtek Z350 (3M ESPE) composite resin...
December 2016: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/28642913/the-effect-of-petroleum-jelly-light-cured-varnish-and-different-storage-media-on-the-flexural-strength-of-glass-ionomer-dental-cements
#4
Kristina Gorseta, Domagoj Glavina, Tomislav Skrinjaric, Beata Czarnecka, John W Nicholson
This study determined the influence of coating with either petroleum jelly or light-cured varnish and storage medium on the flexural strength of glass-ionomer cements (GIC). The flexural strength of two glass-ionomer cements (Fuji Equia Fil and Ketac Molar Aplicap) was measured. Specimens (2 × 2 × 25 mm) were prepared in three groups: uncoated, coated with petroleum jelly, or coated with light-cured varnish (EquiaCoat) cured for 20 s using a cure lamp (Bluephase G2, Ivoclar Vivadent, Schaan, Liechtenstein)...
December 2016: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/28628735/effect-of-shade-opacity-and-layer-thickness-on-light-transmission-through-a-nano-hybrid-dental-composite-during-curing
#5
Hong-Keun Hyun, Carly K Christoferson, Carmem S Pfeifer, Chris Felix, Jack L Ferracane
OBJECTIVE: The aim of this study was to investigate the effect of shade and opacity on the change in light transmission through different thicknesses of a nano-hybrid composite during curing. MATERIALS AND METHODS: Twelve different shades of Venus Diamond (Heraeus Kulzer) were placed in disk shaped molds with thickness of 1, 2, and 3 mm (n = 3 per group) and cured with an LED light-curing unit. Initial, final and average irradiance, and the total amount of energy passing through the specimen were measured using the MARC Resin Calibrator at every 10s for a total of 40s...
June 19, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28626204/intrapulpal-temperature-changes-during-curing-of-different-bulk-fill-restorative-materials
#6
Elif Yasa, Cigdem Atalayin, Gamze Karacolak, Tugrul Sari, L Sebnem Turkun
The aim of this study was to evaluate the intrapulpal temperature changes during the curing of different bulk-fill restorative materials. Ten mandibular molar teeth were selected and occlusal surfaces were removed to obtain a standard 0.5 mm occlusal dentin thickness. Five bulk-fill restorative materials and a conventional resin composite (control) were applied. The intrapulpal temperature changes during the curing of these materials were determined by a device simulating pulpal blood microcirculation. The difference between the initial and maximum temperature values (Δt), was recorded...
June 15, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28623091/dna-repair-and-systemic-lupus-erythematosus
#7
REVIEW
Rithy Meas, Matthew J Burak, Joann B Sweasy
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with no known cure that affects at least five million people worldwide. Monozygotic twin concordance and familial aggregation studies strongly suggest that lupus results from genetic predisposition along with environmental exposures including UV light. The majority of the common risk alleles associated with genetic predisposition to SLE map to genes associated with the immune system. However, evidence is emerging that implicates a role for aberrant DNA repair in the development of lupus...
June 9, 2017: DNA Repair
https://www.readbyqxmd.com/read/28620638/evaluation-of-the-color-stability-of-methyl-methacrylate-and-nylon-base-polymer
#8
Fahimeh Hamedi Rad, Tahereh Ghaffari, Raana Tamgaji
STATEMENT OF THE PROBLEM: Evaluation of the color stability of materials used for the fabrication of the base of complete and partial removable dentures provides important information in relation to their clinical service. The color stability of nylon-based polymers as denture bases, compared to that of acrylic resins, has not been extensively evaluated since to date. PURPOSE: The aim of the present in vitro study was to evaluate the color stability of conventional polymethyl methacrylate and nylon-based polymer materials used for the fabrication of the base of complete and partial removable dentures...
June 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28618330/improvements-in-self-curing-composites
#9
Zbigniew Raszewski, Marek Jałbrzykowski
PURPOSE: The purpose of this study was to test the influence of a barbituric acid derivative acting as a catalyst and small amounts of pyrolytic silica in acrylic resins on color stability, solubility and sorption of a composite. MATERIALS AND METHODS: A series of two-component powder/liquid resin systems were prepared. Monomer-like mixtures (bis-GMA, TEGDMA, tertiary amine 60/40) and a quartz powder with additions of various silica and barbituric acid derivatives were used...
June 12, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28613063/-application-and-outlook-of-three-dimensional-printing-in-prosthetic-dentistry
#10
Y C Sun, R Li, Y S Zhou, Y Wang
At present, three-dimensional (3D) printing has been applied in many aspects in the field of prosthodontics, such as dental models, wax patterns, guide plates, dental restoration and customized implants. The common forming principles include light curing, sintering and melting-condensation, the materials include pure wax, resin, metal and ceramics. However, the printing precision and the strength of multi-material integrated forming, remains to be improved. In addition, as a technology by which the internal structure of a material can be customized manufacturing, further advantage of 3D printing used in the manufacture of dental restoration lies in the customization functional bionic micro-structures, but the related research is still in its infancy...
June 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28609496/effect-of-ceramic-barriers-of-different-thicknesses-on-microhardness-of-light-cured-resin-cements
#11
Yasmin Alves do Nascimento, Ayla Macyelle de Oliveira Correia, Darlon Martins Lima, Sandro Griza, Wilton Mitsunari Takeshita, Adriano Augusto Melo de Mendonça
This study evaluated the microhardness of two resin cements and a low-viscosity resin composite when light-cured under different ceramic thicknesses. A total of 20 samples (10.0 × 1.0 mm) of each material were polymerized by means of a LED light source with an intensity of 1,100 mW/cm(2) for 20 seconds. For each experimental group, different ceramic thicknesses (0.5 mm, 1.0 mm, and 1.5 mm) were applied to each sample. For the control group, the samples were polymerized without the presence of ceramics. Each material was then stored in dry vials that inhibited the passage of light for a period of 24 hours...
July 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28606809/animal-derived-natural-products-used-in-the-bhutanese-sowa-riga-medicine
#12
Karma Yeshi, Paolo Morisco, Phurpa Wangchuk
ETHNOPHARMACOLOGICAL RELEVANCE: Bhutan has two traditional healing systems: a folklore medicine and the Bhutanese Sowa Rigpa medicine (BSM). Three different types of ingredients namely plants, animals (and their derived products) and minerals are used for the preparation of various formulations in combined form. Animals and their derived products are vital ingredients in the preparation of numerous traditional remedies. Unlike medicinal plants, research on medicinal animals has remained largely untouched...
June 9, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28605721/dynamic-analysis-of-bulk-fill-composites-effect-of-food-simulating-liquids
#13
Ahmed Hesham Eweis, Adrian U-Jin Yap, Noor Azlin Yahya
This study investigated the effect of food simulating liquids on visco-elastic properties of bulk-fill restoratives using dynamic mechanical analysis. One conventional composite (Filtek Z350 [FZ]), two bulk-fill composites (Filtek Bulk-fill [FB] and Tetric N Ceram [TN]) and a bulk-fill giomer (Beautifil-Bulk Restorative [BB]) were evaluated. Specimens (12 × 2 × 2mm) were fabricated using customized stainless steel molds. The specimens were light-cured, removed from their molds, finished, measured and randomly divided into six groups...
June 6, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28605612/influence-of-different-curing-modes-on-polymerization-behavior-and-mechanical-properties-of-dual-cured-provisional-resins
#14
S Shibasaki, T Takamizawa, T Suzuki, K Nojiri, A Tsujimoto, W W Barkmeier, M A Latta, M Miyazaki
This study determined the influence of curing mode on polymerization behavior and mechanical properties of dual-cured provisional resins. Three dual-cured bisacryl-based provisional resins were used: Tempsmart (TS; GC Corp), Luxatemp Automix Solar (LX; DMG Chemisch Pharmazeutishe Fabrik GmbH), and Integrity Multi·Cure (IG; Dentsply Caulk). A self-cured bisacryl-based provisional resin, Protemp Plus (PP; 3M ESPE) and a conventional poly(methyl methacrylate) (PMMA) provisional resin, Unifast III (UF; GC Corp) were used as controls...
June 12, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28605610/effect-of-light-curing-exposure-time-shade-and-thickness-on-the-depth-of-cure-of-bulk-fill-composites
#15
A Rodriguez, P Yaman, J Dennison, D Garcia
PURPOSE:   To investigate the effect of different light exposure times, shades, and thicknesses on the depth of cure (DOC) of bulk fill composites. METHODS AND MATERIALS:   Two bulk fill composites, Tetric EvoCeram Bulk Fill (TBF) and Sonic Fill (SF), and a conventional composite, Filtek Supreme Ultra (FSU), were evaluated. Samples (n=10) were made using two different shades (light and dark), thicknesses (2 and 4 mm) and exposure times (20 and 40 seconds). A Tukon 2100B-testing machine was used to obtain three Knoop hardness numbers (KHNs) measured at the top and bottom of each sample, and DOC was calculated as the bottom/top ratio...
June 12, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28604055/deciphering-the-mechanism-of-action-of-wrightia-tinctoria-for-psoriasis-based-on-systems-pharmacology-approach
#16
Sudharsana Sundarrajan, Sajitha Lulu, Mohanapriya Arumugam
OBJECTIVE: Psoriasis is a chronic immune-mediated disorder of the skin. The disease manifests itself with red or silvery scaly plaques distributing over the lower back, scalp, and extensor aspects of limbs. Several medications are available for the treatment of psoriasis; however, high rates of remission and side-effects still persist as a major concern. Siddha, one of the traditional systems of Indian medicine offers cure to many dermatological conditions, including psoriasis. The oil prepared from the leaves of Wrightia tinctoria is prescribed by many healers for the treatment of psoriasis...
June 12, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28603293/impact-of-uv-irradiation-on-multiwall-carbon-nanotubes-in-nanocomposites-formation-of-entangled-surface-layer-and-mechanisms-of-release-resistance
#17
Tinh Nguyen, Elijah J Petersen, Bastien Pellegrin, Justin M Gorham, Thomas Lam, Minhua Zhao, Lipiin Sung
Multiwall carbon nanotubes (MWCNTs) are nanofillers used in consumer and structural polymeric products to enhance a variety of properties. Under weathering, the polymer matrix will degrade and the nanofillers may be released from the products potentially impacting ecological or human health. In this study, we investigated the degradation of a 0.72 % (by mass) MWCNT/amine-cured epoxy nanocomposite irradiated with high intensity ultraviolet (UV) light at various doses, the effects of UV exposure on the surface accumulation and potential release of MWCNTs, and possible mechanisms for the release resistance of the MWCNT surface layer formed on nanocomposites by UV irradiation...
May 2017: Carbon
https://www.readbyqxmd.com/read/28591406/the-use-of-circulating-cathodic-antigen-rapid-test-and-serology-for-diagnosis-of-active-schistosoma-mansoni-infection-in-migrants-in-italy-a-non-endemic-country-a-cross-sectional-study
#18
Laura Infurnari, Laura Galli, Alba Bigoloni, Alessia Carbone, Stefania Chiappetta, Angelo Sala, Norberto Ceserani, Adriano Lazzarin, Antonella Castagna, Giovanni Gaiera/
Diagnosis of schistosomiasis in migrants coming from endemic areas can be difficult, especially in asymptomatic subjects. Light-intensity disease, in fact, may be missed due to the low sensitivity of the stool microscopy and serologic testing cannot distinguish between a resolved infection and an active infection in patients who have been infected and treated in the past, because specific antibodies can persist despite cure. We describe a cross-sectional study conducted on 82 migrants tested for Schistosoma mansoni on single blood (anti-schistosome antibodies, total IgE) and urine [point-of-care (POC) circulating-cathodic-antigen (CCA) test] samples...
June 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28591256/association-of-outcomes-with-comprehension-adherence-and-behavioral-characteristics-of-tuberculosis-patients-using-fixed-dose-combination-therapy-in-contagem-minas-gerais-brazil
#19
Ana Maria Viegas, Silvana Spíndola de Miranda, João Paulo Haddad, Maria das Graças Ceccato, Wânia da Silva Carvalho
The present study aimed to assess the association of outcomes with comprehension, adherence and behavioral characteristics of tuberculosis (TB) patients using fixed-dose combination (FDC) therapy in the city of Contagem, MG, Brazil. This study used standardized questionnaires to collect data. Outcomes included cure in 77.2% (64/ 83), noncompliance with treatment in 20.4% (17/ 83), and absence of organ failure or death cases. The rate of adherence to treatment was high (71.1% - 59/ 83), while the level of comprehension of the treatment was insufficient for the majority of patients (72...
June 1, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28588059/near-infrared-photoimmunotherapy-targeting-prostate-cancer-with-prostate-specific-membrane-antigen-psma-antibody
#20
Tadanobu Nagaya, Yuko Nakamura, Shuhei Okuyama, Fusa Ogata, Yasuhiro Maruoka, Peter L Choyke, Hisataka Kobayashi
Prostate-specific membrane antigen (PSMA) is a membrane protein that is overexpressed manifold in prostate cancer and provides an attractive target for molecular therapy. Near infrared photoimmunotherapy (NIR-PIT) is a highly selective tumor treatment that employs an antibody-photo-absorber conjugate (APC). Here, we describe the efficacy of NIR-PIT, using a fully human IgG1 anti-PSMA monoclonal antibody (mAb), conjugated to the photo-absorber, IR700DX, in a PSMA expressing PC3 prostate cancer cell line. Anti-PSMA-IR700 showed specific binding and cell-specific killing was observed after exposure of the cells to NIR in vitro...
June 6, 2017: Molecular Cancer Research: MCR
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