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https://www.readbyqxmd.com/read/29330300/real-time-imaging-of-yeast-cells-reveals-several-distinct-mechanisms-of-curing-of-the-ure3-prion
#1
Xiaohong Zhao, Jenna Lanz, Danielle Steinberg, Tyler Pease, Joseph M Ahearn, Evgeny E Bezsonov, Elena Staguhn, Evan Eisenberg, Daniel C Masison, Lois E Greene
The [URE3] yeast prion is the self-propagating amyloid form of the Ure2 protein. [URE3] is cured by overexpression of several yeast proteins, including Ydj1, Btn2, Cur1, Hsp42, and human DnaJB6. To better understand [URE3] curing, we used real-time imaging with a yeast strain expressing a GFP-labeled full-length Ure2 construct to monitor the curing of [URE3] over time. [URE3] yeast cells exhibited numerous fluorescent foci, and expression of the GFP-labeled Ure2 affected neither mitotic stability of [URE3] nor the rate of [URE3] curing by the curing proteins...
January 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29326101/pathways-over-time-functional-genomics-research-in-an-introductory-laboratory-course
#2
Todd D Reeves, Douglas M Warner, Larry H Ludlow, Clare M O'Connor
National reports have called for the introduction of research experiences throughout the undergraduate curriculum, but practical implementation at many institutions faces challenges associated with sustainability, cost, and large student populations. We describe a novel course-based undergraduate research experience (CURE) that introduces introductory-level students to research in functional genomics in a 3-credit, multisection laboratory class. In the Pathways over Time class project, students study the functional conservation of the methionine biosynthetic pathway between divergent yeast species...
2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29324684/comparative-effect-of-self-or-dual-curing-on-polymerization-kinetics-and-mechanical-properties-in-a-novel-dental-resin-based-composite-with-alkaline-filler-running-title-resin-composites-with-alkaline-fillers
#3
Nicoleta Ilie
Dental bulk-fill restorations with resin-composites (RBC) are increasing in popularity, but doubts concerning insufficient curing in depth still disconcert clinicians. An alternative might be offered by modern dual-cured RBCs, which additionally provide bioactive properties. This study assessed the impact of additional light-curing on polymerization kinetics, the degree of conversion (DC) and mechanical properties of a novel, dual-cured RBC with alkaline fillers. Since the bioactivity of a material often implies a release of compounds, the mechanical stability in simulated clinical environments was also evaluated...
January 11, 2018: Materials
https://www.readbyqxmd.com/read/29322140/development-of-antioxidant-gliadin-particle-stabilized-pickering-high-internal-phase-emulsions-hipes-as-oral-delivery-systems-and-the-in-vitro-digestion-fate
#4
F Z Zhou, T Zeng, S W Yin, C H Tang, D B Yuan, X Q Yang
In this paper, we demonstrate for the first time the use of gliadin particles to structure algal oil (rich in DHA) and to exert chemical stability against lipid oxidation via the Pickering high internal phase emulsion (HIPE) strategy. The gliadin/chitosan colloid particles (GCCPs) were effectively adsorbed and anchored at the algal oil-water interface. Concomitantly, the particle-coated droplets as building blocks constructed a percolating 3D-network framework, endowing Pickering HIPEs with viscoelastic and self-supporting attributes...
January 11, 2018: Food & Function
https://www.readbyqxmd.com/read/29320464/sti-knowledge-in-berlin-adolescents
#5
Frederik Tilmann von Rosen, Antonella Juline von Rosen, Falk Müller-Riemenschneider, Inken Damberg, Peter Tinnemann
Sexually transmitted infections (STIs) pose a significant threat to individual and public health. They disproportionately affect adolescents and young adults. In a cross-sectional study, we assessed self-rated and factual STI knowledge in a sample of 9th graders in 13 secondary schools in Berlin, Germany. Differences by age, gender, migrant background, and school type were quantified using bivariate and multivariable analyses. A total of 1177 students in 61 classes participated. The mean age was 14.6 (SD = 0...
January 10, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29320294/arresting-leprosy-therapeutic-outcomes-besides-cure
#6
Raúl Necochea López
This essay focuses on the use of the concept of "arrest" in Hansen's disease (leprosy) in the United States in the early to middle part of the 20th century, as well as the transformations the concept underwent with the arrival of sulfone drugs and the implications of these changes for patients and public health officers. An "arrest" was a therapeutic outcome characterized by a long course of treatment, noncontagiousness, a very small chance of reactivation, and a need for postdischarge maintenance that depended on sociomedical infrastructures beyond the clinic as well as self-imposed lifestyle limitations...
February 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29316001/directly-observed-therapy-of-chronic-hepatitis-c-with-ledipasvir-sofosbuvir-in-people-who-inject-drugs-at-risk-for-non-adherence-to-direct-acting-antivirals
#7
Angelika Schütz, Stephan Moser, Cornelia Schwanke, Raphael Schubert, Julian Luhn, Enisa Gutic, Tobias Lang, Michael Schleicher, Hans Haltmayer, Michael Gschwantler
An important subgroup of people who inject drugs (PWID) receiving opioid agonist therapy (OAT), cannot be treated in the setting of a hepatology center and would not regularly ingest their medication when handed to them for self-administration. Our hypothesis was that chronic hepatitis C in these patients could be ideally managed if modern, interferon-free regimens were administered together with OAT under direct observation of a physician or nurse at a low-threshold facility. In this open-label, non-interventional, proof-of-concept study (ClinicalTrials...
January 5, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29305389/before-narrative-episodic-reading-and-representations-of-chronic-pain
#8
Sara Wasson
This article suggests that some illness experience may require a reading practice less concerned with narrative coherence or self-authorship, and more interested in the value of textual fragments, episodes and moments considered outside a narrative framework. Chronic pain can pose multiple challenges to the narrative orientations celebrated in both 'survivorship' discourse and classic medical humanities scholarship. In its recalcitrance to cure, its often mysterious aetiology and its complex blend of somatic, interpersonal and affective elements, representations of chronic pain can require a richer vocabulary of temporality...
January 5, 2018: Medical Humanities
https://www.readbyqxmd.com/read/29299191/comparison-of-two-different-debonding-techniques-in-orthodontic-treatment
#9
Luca Piccoli, Guido Migliau, Laith Konstantinos Besharat, Stefano Di Carlo, Giorgio Pompa, Roberto Di Giorgio
Aim: The purpose of this research is to investigate whether and how the adhesive bond failure site varied in relation to the material used for the orthodontic bonding and debonding technique applied. Materials and methods: Two different methods of orthodontic debonding were included in our survey; cutters for orthodontics and debonding plier. Three different materials for the adhesion of the bracket: composite light curing, self-curing composite and glass ionomer cement...
April 2017: Annali di Stomatologia
https://www.readbyqxmd.com/read/29296115/comparison-of-the-dentin-bond-strength-of-two-self-etch-adhesives-after-prolonged-air-drying-and-additional-light-curing
#10
Pouran Samimi, Masoud Ghodrati, Farinaz Shirban, Maryam Khoroushi
Objectives: It has been reported that the water, solvents, or the primer incorporated into adhesive resins decrease the polymerization, compromise the mechanical properties, reduce the bond strength, and lead to a poor bonding performance of self-etch adhesives. This article evaluated the effect of air-drying and light-curing duration of self-etch adhesives on the micro-shear bond strength between composite resin and dentin. Materials and Methods: A total of 120 extracted sound human third molars were randomly divided into twelve groups (n=10)...
September 2017: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/29285469/bonding-system-choice-and-practices-among-senior-dental-students
#11
Hani Nassar, Hassan El-Shamy
Aim and Objective: This survey investigated bonding system type and composite application rationale by senior dental students at a dental school in Saudi Arabia. Materials and Methods: Eighty-three questionnaires with 15 open and closed questions were randomly distributed to final year dental students about the use of etch and rinse versus self-etch adhesives and application techniques for posterior resin composite. Data were collected, and statistical analysis was done using Chi-square test (0...
November 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29285033/flexural-strength-of-polymethyl-methacrylate-repaired-with-fiberglass
#12
Fariba Golbidi, Maryam Amini Pozveh
Objectives: The purpose of this experimental study was to discover a method to increase the strength of repaired polymethyl methacrylate (PMMA) samples. Materials and Methods: In this experimental study, 40 specimens with the dimensions of 65×10×2.5mm3 were fabricated using heat-curing acrylic resin. Sixteen specimens were repaired with fiberglass and self-curing PMMA, while 16 samples were repaired with self-curing PMMA. Eight specimens were left intact as the control group...
July 2017: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/29284340/on-the-advantage-of-autobiographical-memory-pliability-implantation-of-positive-self-defining-memories-reduces-trait-anxiety
#13
Veronika V Nourkova, Darya A Vasilenko
This paper is devoted to the mechanism of the positive construction of autobiographical memory. Positive construction consists of the spontaneous transformation of memories in the direction of the subjective enhancement of self-competence in past activities to anticipate improvement over time. We speculated that trait anxiety may indicate a failure to exhibit this mechanism that results in a deficit of affirmative self-esteem. We hypothesised that the implantation of positive self-defining memories in anxiety-evoking domains would decrease trait anxiety...
December 28, 2017: Memory
https://www.readbyqxmd.com/read/29282301/inhibition-of-mdm2-by-a-rhein-derived-compound-aq-101-suppresses-cancer-development-in-scid-mice
#14
Lubing Gu, Hailong Zhang, Tao Liu, Alexander Draganov, Sha Yi, Binghe Wang, Muxiang Zhou
A novel small-molecule anthraquinone (AQ) analog, AQ-101, which was synthesized through chemical modification of the core structures of rhein, exhibited potent anticancer activity. In the present study, we evaluated the cancer-inhibiting mechanism of AQ-101 and tested the therapeutic potential of this compound for treating cancer in mice. We found that AQ-101 was able to induce MDM2 protein degradation through a self-ubiquitination and proteasome-mediated mechanism. This AQ-101-induced MDM2 downregulation led to activation of p53, which contributed to apoptosis of acute lymphoblastic leukemia (ALL), especially those with a wild-type p53 phenotype and MDM2 expression in vitro and in vivo...
December 27, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29281944/unveiling-the-maelstrom-of-the-early-breast-cancer-trajectory
#15
Mary Godfrey, Sarah Price, Andrew Long
Length and complexity of illness and treatment in early breast cancer mean that the acute phase may extend over months. Employing concepts of "trajectory" and "work" from chronic illness, we explored the temporality of the illness experience for women as it unfolded from diagnosis through acute treatment. We performed multiple, qualitative interviews with 14 women at critical points in their first year postdiagnosis. We differentiated between subphases of the acute breast cancer trajectory: becoming a person with breast cancer: a turning point; first steps in treatment: struggling to protect self-concept; being and feeling ill: "cure" as suffering; and conditional "recovering": an uncertain future...
December 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/29279569/bond-strength-of-universal-adhesives-to-air-abraded-zirconia-ceramics
#16
Zaid A Al Jeaidi, Mohammed A Alqahtani, Mohamed M Awad, Flávia P Rodrigues, Ali A Alrahlah
The bond strength of universal adhesives to air-abraded zirconia ceramic was evaluated. Overall, 40 zirconia ceramic blocks with dimensions of 6 × 6 × 4 mm were cut from pre-sintered blanks. The sintered blocks were embedded in self-cured acrylic resin. The zirconia blocks were then randomly allocated to four groups (n = 10) in which different universal adhesives were used, except for the control group in which no universal adhesive was used. A silicon mold was used to build the resin cement. All specimens were stored in distilled water for 24 h at 37°C and mounted on a universal testing machine...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/29279083/discovery-of-a-recombinant-babesia-canis-supernatant-antigen-that-protects-dogs-against-virulent-challenge-infection
#17
K Moubri, J Kleuskens, J Van de Crommert, N Scholtes, T Van Kasteren, S Delbecq, B Carcy, E Précigout, A Gorenflot, Th Schetters
Soluble parasite antigens (SPA) in supernatants of in vitro cultures of Babesia canis can be used to vaccinate dogs against virulent B. canis infection. The moment that immunity becomes apparent coincides with the appearance of antibodies against SPA in the serum of the vaccinated animals. This so-called vaccination-challenge serum (VC-serum) was used to precipitate antigens from B. canis culture supernatants in agarose gels. This antigen preparation was then used to analyse the reactivity of sera from vaccinated dogs on western blots...
January 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29276986/imagined-futures-in-living-with-multiple-conditions-positivity-relationality-and-hopelessness
#18
Lindsay-Ann Coyle, Sarah Atkinson
Hope serves as an overarching concept for a range of engagements that demonstrate the benefits of a positive outlook for coping with chronic conditions of ill-health and disability. A dominant engagement through medicine has positioned hope as a desirable attribute and its opposite, hopelessness, as pathological. In this engagement hope is individual, internally located and largely cognitive and able to be learned. Attaining hope reflects a process of coming to terms with the losses associated with long-term conditions and of imagining new meanings and purposes for the future ahead...
December 18, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29259809/the-addition-of-a-tension-night-splint-to-a-structured-home-rehabilitation-programme-in-patients-with-chronic-plantar-fasciitis-does-not-lead-to-significant-additional-benefits-in-either-pain-function-or-flexibility-a-single-blinded-randomised-controlled-trial
#19
Patrick C Wheeler
Objective: To identify any improvements in pain or function in patients with chronic plantar fasciitis following the use of a tension night splint (TNS). Methods: Single-blinded randomised controlled trial, with participants split evenly between intervention group (TNS + home exercise programme/HEP) and control group (HEP only). Follow-up at 3 months, with interim data at 6 weeks. Results: 40 patients recruited. Mean age 52.1 years, 33% male, mean body mass index 30...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29248963/effects-of-occlusal-cavity-configuration-on-3d-shrinkage-vectors-in-a-flowable-composite
#20
Dalia Kaisarly, Moataz El Gezawi, Guangyun Lai, Jian Jin, Peter Rösch, Karl-Heinz Kunzelmann
OBJECTIVE: The objective of this study was to investigate the effects of cavity configuration on the shrinkage vectors of a flowable resin-based composite (RBC) placed in occlusal cavities. MATERIALS AND METHODS: Twenty-seven human molars were divided into three groups (n = 9) according to cavity configuration: "adhesive," "diverging," and "cylindrical." The "adhesive" cavity represented beveled enamel margins and occlusally converging walls, the "diverging" cavity had occlusally diverging walls, and the "cylindrical" cavity had parallel walls (diameter = 6 mm); all cavities were 3 mm deep...
December 16, 2017: Clinical Oral Investigations
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