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https://www.readbyqxmd.com/read/28643812/-conscience-clause-in-end-of-life-care
#1
Ludovica De Panfilis, Daniela Cattaneo, Luisanna Cola, Maddalena Gasparini, Corinna Porteri, Daniela Tarquini, Alessandro Tiezzi, Simone Veronese, Silvia Zullo, Eugenio Pucci
The article proposes a critical reflection on issues that appeal to the conscience clause as part of end of life care can produce and what can guarantee freedom of conscience, self-determination of those involved and respect for the dignity of the sick person. After a philosophical and normative analysis, the article is organized on the basis of two important documents for discussion: a position paper of Società Italiana di Anestesia Analgesia Rianimazione e Terapia Intensiva (SIAARTI) signed by several scientific societies "Grandi insufficienze d'organo end stage: cure intensive o cure palliative?" and the Design of Law currently being debated "Norme in materia di consenso informato e di disposizioni anticipate di trattamento"...
May 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28640536/dynamic-self-assembly-of-magnetic-polymer-composites-in-rotating-frames-of-reference
#2
Konrad Giżynski, Taehoon Lee, Bartosz A Grzybowski
Small ferromagnetic particles suspended in a rotating viscous polymer and subjected to an external static magnetic field dynamically self-assemble into open-lattice, periodic structures. Depending on the orientation of the magnetic field with respect to the system's axis of rotation, these structures range from arrays of parallel plates to single, double, triple, or even quaternary helices. Dynamic self-assembly in this rotating frame of reference can be explained by an interplay between magnetic, dipole-dipole, viscous drag, and centripetal forces...
June 22, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28639189/enhancing-neuronogenesis-and-counteracting-neuropathogenic-gene-haploinsufficiencies-by-rna-gene-activation
#3
Antonello Mallamaci
Small activating RNAs (saRNAs), targeting endogenous genes and stimulating their transcription, are a promising tool for implementing a variety of neurotherapeutic strategies. Among these there is the stimulation of select histogenetic subroutines for purposes of cell-based brain repair, as well as the therapeutic treatment of gene expression deficits underlying severe neurological disorders.We employed RNA activation (RNAa) to transactivate the Emx2 transcription factor gene in embryonic cortico-cerebral precursor cells...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28638709/-cure-for-multiple-sclerosis-ms-evolving-views-of-therapy-goals-in-patients-on-different-stages-of-the-disease-a-pilot-study-in-a-cohort-of-polish-ms-patients
#4
Weronika Chacińska, Marta Brzostowska, Monika Nojszewska, Aleksandra Podlecka-Piętowska, Wiesław W Jędrzejczak, Emilian Snarski
INTRODUCTION: New aggressive treatments promise improvement of results in the treatment of multiple sclerosis (MS), however, with high risk of serious complications. In this study, we analyzed patients' acceptance for risks connected with the MS treatment. METHODS: The study was designed as a prospective nonanonymous online questionnaire. Responders were asked about the definition of the "cure" for MS and crucial goals in the treatment. RESULTS: One hundred and eighty patients filled in the questionnaire (129 women and 51 men), and the mean age was 33 years (SD = 10...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28635521/assessment-of-an-innovative-voluntary-substance-abuse-treatment-program-designed-to-replace-compulsory-drug-detention-centers-in-malaysia
#5
Farrah Khan, Archana Krishnan, Mansur A Ghani, Jeffrey A Wickersham, Jeannia J Fu, Sin How Lim, Sangeeth Kaur Dhaliwal, Adeeba Kamarulzaman, Frederick L Altice
BACKGROUND: As part of an ongoing initiative by the Malaysian government to implement alternative approaches to involuntary detention of people who use drugs, the National Anti-Drug Agency has created new voluntary drug treatment programs known as Cure and Care (C&C) Centers that provide free access to addiction treatment services, including methadone maintenance therapy, integrated with social and health services. OBJECTIVES:   We evaluated early treatment outcomes and client satisfaction among patients accessing C&C treatment and ancillary services at Malaysia's second C&C Center located in Kota Bharu, Kelantan...
February 22, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28629216/amphiphilic-antifogging-anti-icing-coatings-containing-poss-pdmaema-b-psbma
#6
Chuan Li, Xiaohui Li, Chao Tao, Lixia Ren, Yunhui Zhao, Shan Bai, Xiaoyan Yuan
Highly transparent antifogging/anti-icing coatings were developed from amphiphilic block copolymers of polyhedral oligomeric silsesquioxane-poly[2-(dimethylamino)ethyl methacrylate]-block-poly(sulfobetaine methacrylate) (POSS-PDMAEMA-b-PSBMA) with a small amount of ethylene glycol dimethacrylate (EGDMA) via UV-curing. The excellent antifogging properties of the prepared coatings were originated from the hygroscopicity of both PDMAEMA and PSBMA blocks in the semi-interpenetrating polymer network (SIPN) with polymerization of EGDMA, and the hydrophobic POSS aggregated on the surface...
June 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28618330/improvements-in-self-curing-composites
#7
Zbigniew Raszewski, Marek Jałbrzykowski
PURPOSE: The purpose of this study was to test the influence of a barbituric acid derivative acting as a catalyst and small amounts of pyrolytic silica in acrylic resins on color stability, solubility and sorption of a composite. MATERIALS AND METHODS: A series of two-component powder/liquid resin systems were prepared. Monomer-like mixtures (bis-GMA, TEGDMA, tertiary amine 60/40) and a quartz powder with additions of various silica and barbituric acid derivatives were used...
June 12, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28617579/programming-feature-size-in-thermal-wrinkling-of-metal-polymer-bilayer-by-modulating-substrate-visco-elasticity
#8
Anuja Das, Aditya Banerji, Rabibrata Mukherjee
We report a novel strategy to create stress induced self-organized wrinkles in a metal polymer bilayer with programmable periodicity (λS) varying over a wide range, from ≈ 20 m down to ≈ 800 nm by modulating the viscoelasticity of the bottom polymer layer. Substrates with different visco-elasticity are prepared by pre-curing thin films of a thermo-curable poly-dimethylsiloxane (PDMS) elastomer (Sylgard 184) for different durations (tP) prior to deposition of the top aluminum layer by thermal evaporation...
June 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28611755/efficacy-of-phage-therapy-in-controlling-rabbit-colibacillosis-and-changes-in-cecal-microbiota
#9
Jian Zhao, Yan Liu, Chenwen Xiao, Shaojie He, Huochun Yao, Guolian Bao
Phage therapy is a valid weapon that we could use to fight against pathogens. Bacteriophages kill bacteria and self-proliferate in the digestive tract. Furthermore, it was assumed that phage therapy could preserve the existing gut microbiota. In this study, 45 rabbits were equally divided into three groups after they were orally inoculated with pathogenic Escherichia coli to induce gut infection. Each group was treated with bacteriophage ZRP1 (Group P), ciprofloxacin lactate (Group A), or phosphate-buffered solution (PBS) (Group N)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28605901/graphite-templated-amyloid-nanostructures-formed-by-a-potential-pentapeptide-inhibitor-for-alzheimer-s-disease-a-combined-study-of-real-time-atomic-force-microscopy-and-molecular-dynamics-simulations
#10
Na Li, Hyunbum Jang, Ming Yuan, Wanrong Li, Xiaolin Yun, Joon Lee, Qiqige Du, Ruth Nussinov, Jiahua Hou, Ratnesh Lal, Feng Zhang
Self-assembly of peptides is closely related to many diseases, including Alzheimer's, Parkinson's, and prion diseases. Understanding the basic mechanism of this assembly is essential for designing ultimate cure and preventive measures. Template-assisted self-assembly (TASA) of peptides on inorganic substrates can provide fundamental understanding of substrate-dependent peptides assemble, including the role of hydrophobic interface on the peptide fibrillization. Here, we have studied the self-assembly process of a potential pentapeptide inhibitor on the surface of highly oriented pyrolytic graphite (HOPG) using real time atomic force microscopy (RT-AFM) as well as molecular dynamics (MD) simulation...
June 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28605612/influence-of-different-curing-modes-on-polymerization-behavior-and-mechanical-properties-of-dual-cured-provisional-resins
#11
S Shibasaki, T Takamizawa, T Suzuki, K Nojiri, A Tsujimoto, W W Barkmeier, M A Latta, M Miyazaki
This study determined the influence of curing mode on polymerization behavior and mechanical properties of dual-cured provisional resins. Three dual-cured bisacryl-based provisional resins were used: Tempsmart (TS; GC Corp), Luxatemp Automix Solar (LX; DMG Chemisch Pharmazeutishe Fabrik GmbH), and Integrity Multi·Cure (IG; Dentsply Caulk). A self-cured bisacryl-based provisional resin, Protemp Plus (PP; 3M ESPE) and a conventional poly(methyl methacrylate) (PMMA) provisional resin, Unifast III (UF; GC Corp) were used as controls...
June 12, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28597006/effect-of-final-irrigation-protocol-and-etching-mode-on-bond-strength-of-a-multimode-adhesive-in-the-root-canal
#12
Kerstin Bitter, Luise Polster, Haitham Askar, Manja von Stein-Lausnitz, Guido Sterzenbach
PURPOSE: To analyze the effects of ethanol for final post space irrigation and etching mode on the bond strength of fiber posts luted with a mild multimode adhesive (pH 2.3) as compared with a reference group using a self-adhesive resin cement (SAR). MATERIALS AND METHODS: Human anterior teeth were endodontically treated. After post space preparation, the root canals were irrigated using 1% sodium hypochlorite (NaOCl) applied with passive ultrasonic irrigation, followed by either distilled water (control) or distilled water and ethanol 99% as final post space irrigation...
June 8, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28592579/attitudes-and-behaviours-of-adolescents-towards-antibiotics-and-self-care-for-respiratory-tract-infections-a-qualitative-study
#13
Meredith Kd Hawking, Donna M Lecky, Pia Touboul Lundgren, Eman Aldigs, Hind Abdulmajed, Eleni Ioannidou, Demetra Paraskeva-Hadjichambi, Pauline Khouri, Micaela Gal, Andreas Ch Hadjichambis, Demetrios Mappouras, Cliodna Am McNulty
BACKGROUND: To understand attitudes and behaviours of adolescents towards antibiotics, antimicrobial resistance and respiratory tract infections. DESIGN: Qualitative approach informed by the Theory of Planned Behaviour. Semi-structured interviews and focus groups were undertaken. We aimed to inform the development of an intervention in an international setting to improve antibiotic use among adolescents; therefore on completion of thematic analysis, findings were triangulated with qualitative data from similar studies in France, Saudi Arabia and Cyprus to elucidate differences in the behaviour change model and adaptation to diverse contexts...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28592117/mechanisms-regulating-radiosensitivity-of-glioma-stem-cells
#14
Y Liu, Y Shen, T Sun, W Yang
Malignant glioblastoma (GBM) has become a very common and difficult brain tumor given its low cure rate and high recurrence rate. GBMs are resistant to treatments because glioma stem cells (GSCs)/glioma-initiating cells (GICs), a specific subpopulation of GBM, possess properties of tumor stem cells, such as unlimited proficiency, self-renewal, differentiation and resistance to chemotherapy and radiotherapy, and exhibit a very strong DNA repair capability. Radiotherapy has become a preponderant treatment, and researchers have found many significant tumor microenvironmental factors and valuable signaling pathways regulating the GSC radioresistance, including NOTCH, Wnt/β-catenin, Hedgehog, STAT3, and PI3K/AKT/mTOR...
June 8, 2017: Neoplasma
https://www.readbyqxmd.com/read/28587377/network-of-microrna-transcription-factors-target-genes-and-host-genes-in-human-mesothelioma
#15
Guanhua Zhang, Zhiwen Xu, Ning Wang
Significant progress has been made into the elucidation of the etiology of mesothelioma at the level of the genes and miRNA. Nevertheless, researchers in this field remain unable to systematically construct a network that demonstrates the specific relationships between genes, miRNA and transcription factors (TFs). TFs are key regulatory elements that control gene expression. In the present study, according to the transcriptional regulatory rule, three regulatory networks were constructed using experimentally validated elements to explore the pathogenesis of mesothelioma...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28580560/-a-symbol-of-connectedness-between-the-self-and-the-tribal-home-betel-quid-in-the-lives-of-indigenous-taiwanese
#16
Wei-Fen Ma, Chia-Ing Li, Ellen R Gritz, Irene Tamí-Maury, Cho Lam, Cheng-Chieh Lin
BACKGROUND: Betel quid chewing plays a significant role in the development of oral cancer, yet the high prevalence of betel quid use remains a serious health problem in Taiwan, especially among indigenous Taiwanese. PURPOSE: The present study aimed to understand the reasons behind betel-quid chewing among indigenous Taiwanese people by examining the larger context of their culture and traditions. METHODS: This descriptive, qualitative study recruited ten regular betel quid indigenous chewers using purposive and snowball sampling...
June 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/28580462/does-tack-curing-luting-cements-affect-the-final-cure
#17
Daniel Stegall, Daranee Tantbirojn, Jorge Perdigão, Antheunis Versluis
PURPOSE: Short initial light curing or "tack curing" is used to create a semi-gel state in luting cements for easier excess material cleanup. The effect of tack curing on the final cure of luting cements was measured in terms of hardness. MATERIALS AND METHODS: Three cement types were tested: two dual-curing composite cements (RelyX Unicem 2; Maxcem Elite); three light-curing veneer cements (Choice 2; Variolink Esthetic LC; RelyX Veneer); and two self-curing resin-modified glass-ionomer (RMGI) luting cements (RelyX Luting Plus; Nexus RMGI)...
June 2, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28579476/modeling-neurodegenerative-diseases-with-patient-derived-induced-pluripotent-cells-possibilities-and-challenges
#18
REVIEW
Anna Poon, Yu Zhang, Abinaya Chandrasekaran, Phetcharat Phanthong, Benjamin Schmid, Troels T Nielsen, Kristine K Freude
The rising prevalence of progressive neurodegenerative diseases coupled with increasing longevity poses an economic burden at individual and societal levels. There is currently no effective cure for the majority of neurodegenerative diseases and disease-affected tissues from patients have been difficult to obtain for research and drug discovery in pre-clinical settings. While the use of animal models has contributed invaluable mechanistic insights and potential therapeutic targets, the translational value of animal models could be further enhanced when combined with in vitro models derived from patient-specific induced pluripotent stem cells (iPSCs) and isogenic controls generated using CRISPR-Cas9 mediated genome editing...
June 2, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28574777/coping-and-prognostic-awareness-in-patients-with-advanced-cancer
#19
Ryan D Nipp, Joseph A Greer, Areej El-Jawahri, Samantha M Moran, Lara Traeger, Jamie M Jacobs, Juliet C Jacobsen, Emily R Gallagher, Elyse R Park, David P Ryan, Vicki A Jackson, William F Pirl, Jennifer S Temel
Purpose Patients' understanding of their illness is key for making informed treatment decisions, yet studies suggest an association between prognostic awareness and worse quality of life (QOL) and mood among patients with advanced cancer. We sought to explore the relationships among prognostic awareness, coping, QOL, and mood in patients with newly diagnosed, incurable cancer. Methods We assessed patients' self-reported health status and treatment goal (Prognosis and Treatment Perceptions Questionnaire), coping (Brief COPE), QOL (Functional Assessment of Cancer Therapy-General), and mood (Hospital Anxiety and Depression Scale) within 8 weeks of incurable lung or GI cancer diagnosis...
June 2, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28574451/effect-of-montmorillonite-nanogel-composite-fillers-on-the-protection-performance-of-epoxy-coatings-on-steel-pipelines
#20
Ayman M Atta, Ashraf M El-Saeed, Hamad A Al-Lohedan, Mohamed Wahby
Montmorillonite (MMT) clay mineral is widely used as filler for several organic coatings. Its activity is increased by exfoliation via chemical modification to produce nanomaterials. In the present work, the modification of MMT to form nanogel composites is proposed to increase the dispersion of MMT into epoxy matrices used to fill cracks and holes produced by the curing exotherms of epoxy resins. The dispersion of MMT in epoxy improved both the mechanical and anti-corrosion performance of epoxy coatings in aggressive marine environments...
June 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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