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https://www.readbyqxmd.com/read/29126846/sexual-function-and-quality-of-life-in-adult-male-individuals-with-exstrophy-epispadias-complex-a-survey-of-the-german-cure-network
#1
J Traceviciute, N Zwink, E Jenetzky, H Reutter, K Hirsch, R Stein, W H Rösch, A K Ebert
OBJECTIVE: To investigate sexual function and quality of life (QoL) in adult male individuals with exstrophy-epispadias complex (EEC). Data from the German network for congenital uro-rectal malformations (CURE-Net) were used. PATIENTS AND METHODS: 51 males (≥18 years) recruited by CURE-Net between 2009 and 2012 were re-contacted per mail and asked to fill out four questionnaires including International Index of Erectile Function (IIEF-5), Cologne assessment of Erectile Dysfunction (KEED), the Short-Form 36 (SF-36) and one self-designed questionnaire about their medical history, current health status, sexual experience...
November 7, 2017: Urology
https://www.readbyqxmd.com/read/29126444/expectations-towards-participation-in-easily-accessible-pain-management-interventions-a-qualitative-study
#2
Torunn Hatlen Nøst, Aslak Steinsbekk, Liv Riseth, Ola Bratås, Kjersti Grønning
BACKGROUND: People with chronic pain use a range of healthcare services, but they also report a high degree of dissatisfaction with treatments. One reason for dissatisfaction might be participants' expectations towards treatments. The aim of this study was to explore expectations of people with chronic pain towards participation in easily accessible pain management interventions delivered in public primary care. METHODS: A qualitative study using semi-structured individual face-to-face interviews with 21 informants...
November 10, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29123344/parents-knowledge-and-attitude-regarding-their-child-s-cancer-and-effectiveness-of-initial-disease-counseling-in-pediatric-oncology-patients
#3
Manjusha Nair, Lidiya T Paul, P T Latha, Kusumakumary Parukkutty
Objective: To examine parent's knowledge, attitude and psychosocial response regarding their child's cancer and treatment after initial disease counseling by doctor. Materials and Methods: Structured questionnaire based study of 43 mothers of newly diagnosed pediatric cancer patients undergoing treatment in pediatric oncology division. Mothers received initial counseling regarding their child's cancer and treatment from the doctor. Questionnaire was administered 2-6 months after initial counseling and mothers self-reported their responses...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29120754/new-opportunities-and-challenges-to-defeat-cancer-stem-cells
#4
REVIEW
Erika K Ramos, Andrew D Hoffmann, Stanton L Gerson, Huiping Liu
Cancer stem cells (CSCs) are a subpopulation of cancer cells that are capable of self-renewal, proliferation, differentiation, plastic adaptation, and immune regulation, thereby mediating tumorigenesis, metastasis, and therapy resistance. CSCs are associated with cancer progression and clinical outcome in cancer patients. Successful targeting of CSCs will therefore be necessary to eradicate and cure cancer. Functional regulators of stem cell (stemness) signaling pathways in human cancers have brought new opportunities to target CSCs and reframe cancer-targeting strategies in clinical settings...
November 2017: Trends in Cancer
https://www.readbyqxmd.com/read/29119093/surface-modification-for-bonding-between-amalgam-and-orthodontic-brackets
#5
Wittawat Wongsamut, Sirichom Satrawaha, Kornchanok Wayakanon
OBJECTIVE: Testing of methods to enhance the shear bond strength (SBS) between orthodontic metal brackets and amalgam by sandblasting and different primers. MATERIALS AND METHODS: Three hundred samples of amalgam restorations (KerrAlloy(®)) were prepared in self-cured acrylic blocks, polished, and divided into two groups: nonsandblasted and sandblasted. Each group was divided into five subgroups with different primers used in surface treatment methods, with a control group of bonded brackets on human mandibular incisors...
October 2017: Journal of Orthodontic Science
https://www.readbyqxmd.com/read/29118975/interfacial-microscopic-examination-and-chemical-analysis-of-resin-dentin-interface-of-self-adhering-flowable-resin-composite
#6
Tamer M Hamdy
Background: The newly introduced self-adhering flowable resin-composites decrease the required time for application by incorporation of an acidic adhesive monomer, thus reducing the number of the steps, but its bonding is still uncertain. The aim of this study was to evaluate the interfacial microscopic examination and chemical analysis at the resin-dentin interface of a self-adhering flowable resin composite (Vertise-Flow) versus a total-etch (Te-Econom Plus) resin composite, using an etching agent (Eco-Etch gel) and  bonding agent (Single Bond Universal)...
2017: F1000Research
https://www.readbyqxmd.com/read/29107146/nabi-a-novel-%C3%AE-sheet-breaker-inhibits-a%C3%AE-aggregation-and-neuronal-toxicity-therapeutic-implications-for-alzheimer-s-disease
#7
Ja-Young Jang, Hyangshuk Rhim, Seongman Kang
Amyloid beta (Aβ) aggregates are an important therapeutic target for Alzheimer's disease (AD), a fatal neurodegenerative disease. To date, AD still remains a big challenge due to no effective treatments. Based on the property that Aβ aggregates have the cross-β-structure, a common structural feature in amyloids, we systemically designed the Aβ-aggregation inhibitor that maintains Aβ-interacting ability but removes toxic part from SOD1 (superoxide dismutase 1)-G93A. We identified NABi (Natural Aβ Binder and Aβ-aggregation inhibitor) composed of β2-3 strands, a novel breaker of Aβ aggregation, which does not self-aggregate and has no cytotoxicity at all...
January 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29103788/sclerotherapy-for-the-management-of-rectal-prolapse-in-children
#8
Scott C Dolejs, Justin Sheplock, Robert J Vandewalle, Mathew P Landman, Frederick J Rescorla
PURPOSE: Rectal prolapse is a commonly occurring and usually self-limited process in children. Surgical management is indicated for failures of conservative management. However, the optimal approach is unknown. The purpose of this study is to determine the efficacy of sclerotherapy for the management of rectal prolapse. METHODS: This was a retrospective review of children <18years with rectal prolapse who underwent sclerotherapy, predominantly with peanut oil (91%), between 1998 and 2015...
October 10, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29101710/a-qualitative-exploration-of-the-experiences-needs-and-roles-of-caregivers-during-and-after-cancer-treatment-that-s-what-i-say-i-m-a-relative-survivor
#9
Elliott Tolbert, Janice Bowie, Claire Snyder, Elissa Bantug, Katherine Smith
PURPOSE: The transition out of acute cancer treatment has been identified as a time of stress and uncertainty for cancer survivors, but little is known about how caregivers fare during this period. In this paper, we discuss caregiving work up to and including transition from initial care and the needs of caregivers during transition and beyond. METHODS: We held four focus groups with breast, prostate, and colorectal cancer survivors who had completed treatment with intent to cure and two with caregivers for the same population...
November 3, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29098997/adverse-drug-reactions-and-treatment-outcome-analysis-of-dots-plus-therapy-of-mdr-tb-patients-at-district-tuberculosis-centre-a-four-year-retrospective-study
#10
Arif I Dela, Nitish Kumar D Tank, Anil P Singh, Kiran G Piparva
BACKGROUND: Treatment of multidrug-resistant tuberculosis (MDR-TB) requires the use of expensive and toxic second-line anti-tubercular drugs which are given for a longer duration. Adverse drug reactions (ADRs) of second-line antitubercular drugs affect compliance and thereby treatment outcome. We set out to analyze ADRs and treatment outcome of MDR-TB patients receiving directly observed treatments plus therapy. MATERIALS AND METHODS: A retrospective study of registered MDR-TB cases at district tuberculosis center during 2010-2014 was performed...
November 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29098296/manipulation-of-panx1-activity-increases-the-engraftment-of-transplanted-lacrimal-gland-epithelial-progenitor-cells
#11
Liana V Basova, Xin Tang, Takeshi Umasume, Anastasia Gromova, Tatiana Zyrianova, Taisia Shmushkovich, Alexey Wolfson, Dillon Hawley, Driss Zoukhri, Valery I Shestopalov, Helen P Makarenkova
Purpose: Sjögren's syndrome is a systemic chronic autoimmune inflammatory disease that primarily targets the salivary and lacrimal glands (LGs). Currently there is no cure; therefore, cell-based regenerative therapy may be a viable option. LG inflammation is facilitated by extracellular ATP and mediated by the Pannexin-1 (Panx1) membrane channel glycoprotein. We propose that suppression of inflammation through manipulation of Panx1 activity can stimulate epithelial cell progenitor (EPCP) engraftment...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29098160/micro-raman-vibrational-identification-of-10-mdp-bond-to-zirconia-and-shear-bond-strength-analysis
#12
Diego Martins De-Paula, Alessandro D Loguercio, Alessandra Reis, Natasha Marques Frota, Radamés Melo, Kumiko Yoshihara, Victor Pinheiro Feitosa
So far, there is no report regarding the micro-Raman vibrational fingerprint of the bonds between 10-methacryloyloxy-decyl dihydrogen phosphate (10-MDP) and zirconia ceramics. Thus, the aim of this study was to identify the Raman vibrational peaks related to the bonds of 10-MDP with zirconia, as well as the influence on microshear bond strength. Micro-Raman spectroscopy was employed to assess the vibrational peak of 10-MDP binding to zirconia. Microshear bond strength of the dual-cure resin cement to zirconia with the presence of 10-MDP in composition of experimental ceramic primer and self-adhesive resin cement was also surveyed...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29097418/prevalence-and-treatment-outcomes-of-routine-chlamydia-trachomatis-neisseria-gonorrhoeae-and-trichomonas-vaginalis-testing-during-antenatal-care-gaborone-botswana
#13
Adriane Wynn, Doreen Ramogola-Masire, Ponatshego Gaolebale, Neo Moshashane, Ontiretse Sickboy, Sofia Duque, Elizabeth Williams, Klara Doherty, Jeffrey D Klausner, Chelsea Morroni
OBJECTIVES: Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) are curable, mostly asymptomatic, STIs that cause adverse maternal and perinatal outcomes. Most countries do not test for those infections during antenatal care. We implemented a CT, NG and TV testing and treatment programme in an antenatal clinic in Gaborone, Botswana. METHODS: We conducted a prospective study in the antenatal clinic at Princess Marina Hospital in Gaborone, Botswana...
November 2, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29084237/a-dominant-negative-mutant-inhibits-multiple-prion-variants-through-a-common-mechanism
#14
Fen Pei, Susanne DiSalvo, Suzanne S Sindi, Tricia R Serio
Prions adopt alternative, self-replicating protein conformations and thereby determine novel phenotypes that are often irreversible. Nevertheless, dominant-negative prion mutants can revert phenotypes associated with some conformations. These observations suggest that, while intervention is possible, distinct inhibitors must be developed to overcome the conformational plasticity of prions. To understand the basis of this specificity, we determined the impact of the G58D mutant of the Sup35 prion on three of its conformational variants, which form amyloids in S...
October 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29083086/polymerization-shrinkage-and-porosity-profile-of-dual-cure-dental-resin-cements-with-different-adhesion-to-dentin-mechanisms
#15
Adrieli Burey, Paulo José Dos Reis, Bruno Luiz Santana Vicentin, Cássia Cilene Dezan Garbelini, Márcio Grama Hoeppner, Carlos Roberto Appoloni
This research aims to probe the porosity profile and polymerization shrinkage of two different dual cure resin cements with different dentin bonding systems. The self-adhesive resin cement RelyX U200 (named RU) and the conventional Allcem Core (named AC) were analyzed by x-ray microtomography (μCT) and Scanning Electron Microscopy (SEM). Each cement was divided into two groups (n = 5): dual-cured (RUD and ACD) and self-cured (RUC and ACC). μCT demonstrated that the method of polymerization does not influence the porosity profile but the polymerization shrinkage...
October 30, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29076713/comparative-evaluation-of-micro-leakage-of-two-newer-glass-ionomer-cements-in-primary-molars-immersed-in-three-beverages-in-vitro-study
#16
P Balgi, F Katge, D Pradhan, S Shetty, B Rusawat, S Pol
Introduction: The dietary habits of children expose the oral cavity to challenging environments. A durable interface between the restorative material and tooth surface is essential to ensure marginal integrity thereby contributing to the longevity of restoration. Objectives: The objective of this study was to compare the micro-leakage of two newer glass ionomer cements (SDI Riva Self Cure GIC and GC Fuji IX GP EXTRA) in primary molars immersed in sugarcane juice, chocolate milk and mango drink...
September 30, 2017: Ceylon Medical Journal
https://www.readbyqxmd.com/read/29071026/in-vitro-effect-of-bleaching-with-810-nm-and-980-nm-diode-laser-on-microhardness-of-self-cure-and-light-cure-glass-ionomer-cements
#17
Ladan Ranjbar Omrani, Sara Khoshamad, Elham Tabatabaei Ghomshe, Nasim Chiniforush, Sedighe Sadat Hashemi Kamangar
Introduction: This study sought to assess the effect of bleaching combined with irradiation of 810 nm and 980 nm diode laser on microhardness of 2 commonly used self-cure and light-cure glass ionomer cements (GICs) in comparison with conventional bleaching (without laser). Methods: In this in vitro, experimental study, 60 samples were fabricated of A2 shade of Fuji IX and Fuji II LC GICs (n=30) and each group was divided into 3 subgroups (n=10). The first subgroups were subjected to bleaching with Opalescence Xtra Boost plus 980 nm diode laser irradiation...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29071024/fracture-resistance-of-incisal-fragments-following-reattachment-with-different-techniques-in-simulated-crown-fractures
#18
Fatih Tulumbacı, Volkan Arıkan, Aylin Akbay Oba, Serdar Bağlar
Introduction: The aim of the present study was to evaluate and compare the effect of acidetching and Er, Cr:YSGG laser treatment before the reattachment of incisal fragments in coronal fractures of permanent incisor teeth. Methods: Sixty-six sound human maxillary incisors were randomly divided into 3 groups (n=22). Teeth were embedded in self-cure acrylic resins by leaving one-third of the crowns out, and uncomplicated crown fractures were obtained using an Instron testing device. The fragments were reattached using 3 different procedures and a hybrid resin composite (Z250): Group I: Acid etching + Prime & Bond NT; Group II: Er,Cr:YSGG + Prime & Bond NT; Group III: Er,Cr:YSGG + Acid etching + Prime & Bond NT...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29060440/modelling-and-analysis-of-four-telemedicine-italian-experiences
#19
Samanta Rosati, Maddalena Zema, Cristina Castagneri, Fulvio Marchetti, Gabriella Balestra
In the last 10 years the European population aged 65 years and over grew of 2.3%, with Italy having the highest share of elderly persons in the total population. OPLON (OPportunities for active and healthy LONgevity) is a project supported by the Italian Ministry of Education, Universities, and Research aiming to identify and prevent frailty and to improve the life quality of elderly subjects. The main goal of OPLON is to develop a "Care&Cure" model for the management of subjects with different morbidities and co-morbidities, adaptable to the subject's risk level and to the regional contexts...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29054420/selenium-and-cancer-stem-cells
#20
Giuseppe Murdolo, Desirée Bartolini, Cristina Tortoioli, Marta Piroddi, Pierangelo Torquato, Francesco Galli
Selenium (Se) is an essential micronutrient that functions as "redox gatekeeper" and homeostasis factor of normal and cancer cells. Epidemiology and experimental studies, in the last years suggested that both inorganic and organic forms of Se may have favorable health effects. In this regard, a protective action of Se on cellular systems that may help preventing cancer cell differentiation has been demonstrated, while the hypothesis that Se compounds may cure cancer and its metastatic diffusion appears speculative and is still a matter of investigation...
2017: Advances in Cancer Research
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