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https://www.readbyqxmd.com/read/28437512/dentist-practice-patterns-and-therapeutic-confidence-in-the-treatment-of-pain-related-to-temporomandibular-disorders-in-a-dental-practice-based-research-network
#1
Naoki Kakudate, Yoko Yokoyama, Futoshi Sumida, Yuki Matsumoto, Valeria V Gordan, Gregg H Gilbert, Ana M Velly, Eric L Schiffman
AIMS: To quantify the practice patterns of Japanese dentists in the management of pain related to temporomandibular disorders (TMD) and to identify specific characteristics that are significantly associated with the decision to perform occlusal adjustment for TMD-related pain. METHODS: A cross-sectional study was conducted consisting of a questionnaire survey of dentists affiliated with the Dental Practice-Based Research Network Japan (JDPBRN) (n = 148). Participants were asked how they diagnosed and treated TMD-related pain...
April 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28434261/strategies-to-prevent-infections-associated-with-cardiovascular-implantable-electronic-devices
#2
Bharath Raj Palraj, Saira Farid, M Rizwan Sohail
Infections involving cardiovascular implantable electronic devices (CIED) are associated with high morbidity and mortality and substantial financial cost. In the past two decades, the rate of CIED infections has increased disproportionate to the number of devices implanted, likely due to aging patient population with multiple comorbidities. Microbial contamination of the generator pocket and or leads by skin flora at the time of implantation is a major mechanism for early CIED infections. Due to resistance to host immune cells and antibiotics caused by biofilm formation, complete removal of the device generator and leads is required to achieve cure...
April 24, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28431189/to-cure-or-not-to-cure-differential-effects-of-the-chaperone-sorting-factor-cur1-on-yeast-prions-are-mediated-by-the-chaperone-sis1
#3
Yury A Barbitoff, Andrew G Matveenko, Svetlana E Moskalenko, Olga M Zemlyanko, Gary P Newnam, Ayesha Patel, Tatiana A Chernova, Yury O Chernoff, Galina A Zhouravleva
Yeast self-perpetuating protein aggregates (prions) provide a convenient model for studying various components of the cellular protein quality control system. Molecular chaperones and chaperone-sorting factors, such as yeast Cur1 protein, play key role in proteostasis via tight control of partitioning and recycling of misfolded proteins. In this study, we show that, despite the previously described ability of Cur1 to antagonize the yeast prion [URE3], it enhances propagation and phenotypic manifestation of another prion, [PSI(+) ]...
April 21, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28428184/clinical-and-cost-effectiveness-safety-and-acceptability-of-community-intravenous-antibiotic-service-models-civas-systematic-review
#4
E D Mitchell, C Czoski Murray, D Meads, J Minton, J Wright, M Twiddy
OBJECTIVE: Evaluate evidence of the efficacy, safety, acceptability and cost-effectiveness of outpatient parenteral antimicrobial therapy (OPAT) models. DESIGN: A systematic review. DATA SOURCES: MEDLINE, EMBASE, CINAHL, Cochrane Library, National Health Service (NHS) Economic Evaluation Database (EED), Research Papers in Economics (RePEc), Tufts Cost-Effectiveness Analysis (CEA) Registry, Health Business Elite, Health Information Management Consortium (HMIC), Web of Science Proceedings, International Pharmaceutical Abstracts, British Society for Antimicrobial Chemotherapy website...
April 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28428160/simulated-conversations-with-virtual-humans-to-improve-patient-provider-communication-and-reduce-unnecessary-prescriptions-for-antibiotics-a-repeated-measure-pilot-study
#5
Antoinette Schoenthaler, Glenn Albright, Judith Hibbard, Ron Goldman
BACKGROUND: Despite clear evidence that antibiotics do not cure viral infections, the problem of unnecessary prescribing of antibiotics in ambulatory care persists, and in some cases, prescribing patterns have increased. The overuse of antibiotics for treating viral infections has created numerous economic and clinical consequences including increased medical costs due to unnecessary hospitalizations, antibiotic resistance, disruption of gut bacteria, and obesity. Recent research has underscored the importance of collaborative patient-provider communication as a means to reduce the high rates of unnecessary prescriptions for antibiotics...
April 19, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/28421005/autoimmune-aspects-of-neurodegenerative-and-psychiatric-diseases-a-template-for-innovative-therapy
#6
REVIEW
Peter de Haan, Hans C Klein, Bert A 't Hart
Neurodegenerative and psychiatric diseases (NPDs) are today's most important group of diseases, surpassing both atherosclerotic cardiovascular disease and cancer in morbidity incidence. Although NPDs have a dramatic impact on our society because of their high incidence, mortality, and severe debilitating character, remarkably few effective interventions have become available. The current treatments, if available, comprise the lifelong intake of general immunosuppressants to delay disease progression or neurotransmitter antagonists/agonists to dampen undesired behaviors...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28417630/self-healable-and-reprocessable-polysulfide-sealants-prepared-from-liquid-polysulfide-oligomer-and-epoxy-resin
#7
Wentong Gao, Mengyao Bie, Fu Liu, Pengshan Chang, Yiwu Quan
Polysulfide sealants have been commercially applied in many industrial fields. This paper studied the self-healing property of the epoxy resin cured polysulfide sealants for the first time. The obtained sealants showed a flexible range of the ultimate elongation from 157 to 478% and tensile strength from 1.02 to 0.75 MPa corresponding to different polysulfide oligomers. By taking advantage of the dynamic reversible exchange of disulfide bonds, the polysulfide sealants exhibited good self-healing ability under a moderate thermal stimulus...
April 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28413987/alzheimer-s-disease-like-early-phase-brain-pathogenesis-self-curing-amelioration-of-neurodegeneration-from-pro-inflammatory-wounding-to-anti-inflammatory-healing
#8
Jiang He, Tao Liao, Guo-Xin Zhong, Ji-Da Zhang, Yan-Ping Chen, Qi Wang, Qing-Ping Zeng
The etiological initiators of neuroinflammation remain inclusive, and effective interventions to block neurodegeneration are unavailable. Surprisingly, we found collagen II-combined complete Freund's adjuvant (CC) that usually induces rheumatoid arthritis (RA) also drives Alzheimer's disease (AD)-like neurodegeneration in mice. CC not only upregulates the cerebral pro-inflammatory cytokines including tumor necrosis factor α (TNF-α) and interleukin 8 (IL-8), but also downregulates the cerebral interleukin 10 (IL-10), an anti-inflammatory cytokine, and tyrosine hydroxylase (TH), a rate-limiting enzyme for biosynthesis of the anti-inflammatory neurotransmitter dopamine...
April 17, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28413739/genetic-modulation-therapy-through-stem-cell-transplantation-for-human-immunodeficiency-virus-1-infection
#9
REVIEW
Varshil Mehta, Divya Chandramohan, Shivika Agarwal
Highly active anti-retroviral treatment has changed the dimensions of the outcomes for patients suffering from human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). However, HIV infection is still an ailment which is spreading throughout the world extensively. Given the confinements of the present restorative methodologies and the non-availability of any strategic vaccination against HIV, there is a squeezing need to build a therapeutic treatment. Viral tropism for HIV includes CD4+ cells, macrophages, and microglial cells, and it is through binding with co-receptors C-C chemokine receptor type 5 (CCR5) and C-X-C chemokine receptor type 4 (CXCR4)...
March 13, 2017: Curēus
https://www.readbyqxmd.com/read/28402106/reply-to-comment-on-monitoring-network-and-interfacial-healing-processes-by-broadband-dielectric-spectroscopy-a-case-study-on-natural-rubber
#10
Marianella Hernandez, Antonio Mattia Grande, Sybrand van der Zwaag, Santiago J Garcia
Das et al. comment our publication on the use of broadband dielectric spectroscopy as a potential tool for monitoring healing processes in natural rubber. They argue that our interpretation of self-healing processes should be handled with care and that critical issues like rubber tackiness and sample fabrication for dielectric experiments were not properly addressed. We agree that tackiness in partially cured rubber does exist and that interpretation of dielectric experiments requires detailed insight into both the processes and the method, but we will try and re-argue below the correctness of our approach as reported in our publication...
April 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28399053/short-course-regimens-of-liposomal-amphotericin-b-for-the-treatment-of-mediterranean-visceral-leishmaniasis-in-children-an-11-year-retrospective-study-at-a-tertiary-care-center
#11
Panagiotis Krepis, Ioanna Argyri, Adamantia Krepi, Areti Syrmou, Nikos Spyridis, Maria Tsolia
BACKGROUND: Visceral leishmaniasis (VL) remains an important public health problem in endemic regions. Current anti-leishmanial agents share several limitations including potentially serious side effects and the risk of clinical failure. OBJECTIVES: Aim of the present study was to examine the effectiveness and safety of short-course liposomal amphotericin B (L-AmB) regimens in the treatment of childhood VL in our area. METHODS: The cases of 43 VL patients (20 males, 23 females, mean age 4...
April 10, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28393821/spectrophotometric-analysis-of-crown-discoloration-induced-by-two-different-sealers-an-in-vitro-study
#12
Rashmi Keshav Chahande, Sanjay S Patil, Vandana Gade, Rishikesh Meshram, Deepika J Chandhok, Deepa A Thakur
CONTEXT: Endodontic materials have been assessed with regards to their potential for dental staining. AIMS: To evaluate the coronal discoloration effect of Apexit Plus and Resino Seal in mandibular premolars using spectrophotometer. SETTINGS AND DESIGN: The study design was original research. MATERIALS AND METHODS: Forty human single-rooted mandibular first premolar teeth were selected for the study. They were divided into four groups of ten specimens each...
January 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28389183/influence-of-the-cross-linking-agent-on-mechanical-properties-of-pmma-powder-with-compromised-particle-morphology
#13
Tassanaporn Saen-Isara, Surachai Dechkunakorn, Niwat Anuwongnukroh, Toemsak Srikhirin, Siriporn Tanodekaew, Wassana Wichai
OBJECTIVE: To investigate the effect of a cross-linking agent on the mechanical properties of self-cured orthodontic acrylic resin using PMMA powder (CPM-PMMA) with a compromised microstructure. MATERIALS AND METHODS: The mechanical properties of three sample groups were investigated in this study: CPM-PMMA, orthocryl and orthoplast. CPM-PMMA powder was prepared by suspension polymerization. It was mixed with a commercially available liquid (orthocryl) to yield a test specimen and to compare its flexural properties and Vicker hardness with the two commercial products...
April 4, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28384981/fracture-resistance-of-endodontically-treated-roots-restored-with-fiber-posts-using-different-resin-cements-an-in-vitro-study
#14
Swetha Gopal, Sujatha Irodi, Deepak Mehta, Shankar Subramanya, Vinay Kumar Govindaraju
INTRODUCTION: The influence of the remaining coronal tooth structure along with intra-radicular esthetic posts increases fracture resistance of fractured teeth especially in the anterior region. The advent of resin based luting cements improves the adhesion of fiber posts. AIM: To evaluate the fracture resistance of endodontically treated roots restored with fiber posts using different resin cements - Calibra (etch and rinse), PermaFlo® DC (self-etch primer) and SmartCem2 (self-adhesive)...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28381242/the-150-most-important-questions-in-cancer-research-and-clinical-oncology-series-questions-15-24-edited-by-chinese-journal-of-cancer
#15
EDITORIAL
(no author information available yet)
To accelerate our endeavors to overcome cancer, Chinese Journal of Cancer has launched a program of publishing 150 most important questions in cancer research and clinical oncology. In this article, 10 more questions are presented as follows. Question 15: Can tumor-induced erythrogenesis provide qualified red blood cells for carrying oxygen to distant organs? Question 16: Can we overcome tumor resistance to platinum-containing antineoplastic drugs by activating the sensitivity factors in the tumor? Question 17: How can a cancer cell stay dormant for years? Question 18: Why do cancer cells use distinct transcriptomic and proteomic programs to reach the same metastatic phenotype? Question 19: Why do some cancers regress spontaneously? Question 20: What are the regulatory mechanisms occurring in donor cells that determine selective sorting of biological content into vesicles and their biological consequences in recipient cells? Are the genetic transfer and exchange of biological messages between cells transient? Is the phenotypic manipulation of recipient cells temporary or prolonged and persistent? If extracellular vesicles possess immune-modulatory potential, how could they be exploited for immune interventions and cancer immunotherapy? Presumably the cargo of extracellular vesicles reflects the cells of their origin and can be used for cancer diagnosis, how could the uniform/stringent capture criteria be met universally for applying EVs in point-of-care diagnostics for cancer patients? Question 21: Can we use self-sampling technologies to monitor the tumor genetic alterations for more precise targeted therapy? Can we cure a heterogeneous tumor by sequentially targeting the driver molecules? Question 22: Can we postpone the onset of non-infection-related cancers? Question 23: How many types of cells can jointly form the tumor vasculature to provide blood supply for tumor progression? Question 24: How tumor cells transmit their epigenetic features to daughter cells and maintain the malignant phenotype?...
April 5, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28373280/heat-shock-protein-104-hsp104-mediated-curing-of-psi-yeast-prions-depends-on-both-psi-conformation-and-the-properties-of-the-hsp104-homologs
#16
Xiaohong Zhao, Ramon Rodriguez, Rebecca E Silberman, Joseph M Ahearn, Sheela Saidha, Kaelyn C Cummins, Daniel Masison, Evan Eisenberg, Lois E Greene
Prions arise from proteins that have two possible conformations: properly folded and non-infectious, or misfolded and infectious. The [PSI (+) ] yeast prion, which is the misfolded, self-propagating form of the translation termination factor eRF3 (Sup35), can be cured of its infectious conformation by overexpression of Hsp104, which helps dissolve the prion seeds. This dissolution depends on the trimming activity of Hsp104, which reduces the size of the prion seeds without increasing their number. To further understand the relationship between trimming and curing, trimming was followed by measuring the loss of GFP-labeled Sup35 foci from both strong and weak [PSI (+) ] variants; the former variant has more seeds and less soluble Sup35 than the latter...
April 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28370775/reactive-hybrid-of-polyhedral-oligomeric-silsesquioxane-poss-and-sulfur-as-a-building-block-for-self-healing-materials
#17
Ho-Keng Lin, Ying-Ling Liu
This work demonstrates a new reactive and functional hybrid (S-MMA-POSS) of polyhedral oligomeric silsesquioxane (POSS) and sulfur prepared with a direct reaction between a multifunctional methacrylated POSS compound (MMA-POSS) and elemental sulfur (S8 ) through the "inverse vulcanization" process. S-MMA-POSS is an effective building block for imparting self-healing ability to the corresponding thermally crosslinked POSS-containing nanocomposites through a self-curing reaction and co-curing reaction with conventional thermosetting resins...
March 30, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28348595/in-vitro-comparative-evaluation-of-different-types-of-impression-trays-and-impression-materials-on-the-accuracy-of-open-tray-implant-impressions-a-pilot-study
#18
Sonam Gupta, Aparna Ichalangod Narayan, Dhanasekar Balakrishnan
Purpose. For a precise fit of multiple implant framework, having an accurate definitive cast is imperative. The present study evaluated dimensional accuracy of master casts obtained using different impression trays and materials with open tray impression technique. Materials and Methods. A machined aluminum reference model with four parallel implant analogues was fabricated. Forty implant level impressions were made. Eight groups (n = 5) were tested using impression materials (polyether and vinylsiloxanether) and four types of impression trays, two being custom (self-cure acrylic and light cure acrylic) and two being stock (plastic and metal)...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28346424/skp2-deficiency-restricts-the-progression-and-stem-cell-features-of-castration-resistant-prostate-cancer-by-destabilizing-twist
#19
D Ruan, J He, C-F Li, H-J Lee, J Liu, H-K Lin, C-H Chan
Castration-resistant prostate cancer (CRPC) remains a major clinical challenge because of the lack of effective targeted therapy for its treatment. The mechanism underlying how CRPC gains resistance toward hormone depletion and other forms of chemotherapy is poorly understood. Research on understanding the factors that drive these processes is desperately needed to generate new therapies to cure the disease. Here, we discovered a fundamental role of S-phase protein kinase 2 (Skp2) in the formation and progression of CRPC...
March 27, 2017: Oncogene
https://www.readbyqxmd.com/read/28336903/melanin-associated-synthesis-of-sers-active-nanostructures-and-the-application-for-monitoring-of-intracellular-melanogenesis
#20
Haixin Dong, Zhiming Liu, Huiqing Zhong, Hui Yang, Yan Zhou, Yuqing Hou, Jia Long, Jin Lin, Zhouyi Guo
Melanin plays an indispensable role in the human body. It serves as a biological reducer for the green synthesis of precious metal nanoparticles. Melanin-Ag nanocomposites were successfully produced which exhibited very strong surface-enhanced Raman scattering (SERS) effect because of the reducibility property of melanin. A melanin-Ag composite structure was synthesized in situ in melanin cells, and SERS technique was performed for the rapid imaging and quantitative assay of intracellular melanin. This imaging technique was also used to successfully trace the formation and secretion of intracellular melanin after stimulation with melanin-stimulating hormones...
March 20, 2017: Nanomaterials
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