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https://www.readbyqxmd.com/read/29781519/assessment-of-vertebral-microarchitecture-in-overt-and-mild-cushing-s-syndrome-using-trabecular-bone-score
#1
Helene Vinolas, Virginie Grouthier, Nadia Mehsen-Cetre, Amandine Boisson, Renaud Winzenrieth, Thierry Schaeverbeke, Charles Mesguich, Laurence Bordenave, Antoine Tabarin
OBJECTIVE: Osteoporotic fractures associated with Cushing's syndrome (CS) may occur despite normal bone mineral density (BMD). Few studies have described alterations in vertebral microarchitecture in glucocorticoid-treated patients and during CS. Trabecular bone score (TBS) estimates trabecular microarchitecture from dual-energy X-ray absorptiometry acquisitions. Our aim was to compare vertebral BMD and TBS in patients with overt CS and mild autonomous cortisol secretion (MACE), and following cure of overt CS...
May 21, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29776573/duration-of-dual-antiplatelet-therapy-and-outcome-in-patients-with-acute-coronary-syndrome-undergoing-percutaneous-revascularization-a-meta-analysis-of-11-randomized-trials
#2
Monica Verdoia, Elvin Khedi, Claudia Ceccon, Harry Suryapranata, Giuseppe De Luca
BACKGROUND: Acute coronary syndromes (ACS) represent a context of higher thrombotic risk, where larger advantages have been achieved by the administration of dual antiplatelet therapy (DAPT). However, the indication of 1 year DAPT after coronary angioplasty for ACS has been supported by an outdated randomized trial (PCI-CURE). In addition, the initial fear of late thrombotic events emerged with first generation drug-eluting stents (DES), that suggested the need of a prolonged DAPT prescription, has been completely overcome by the recent technological evolution of DES, that have shown faster re-endothelization and lower rates of late thrombotic complications...
August 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29775637/modified-resin-infiltration-of-non-micro-and-cavitated-proximal-caries-lesions-in-vitro
#3
H Askar, F Schwendicke, J Lausch, H Meyer-Lueckel, S Paris
OBJECTIVE: Infiltrant resin (IR) is currently indicated for non-cavitated caries lesions. However, modifying the technique might expand its indication spectrum to micro-cavitated lesions. The present study aimed to evaluate the penetration/filling ability of a newly developed micro-filled infiltrant resin (MFIR) in non-, micro- and cavitated natural caries lesions. MATERIALS AND METHODS: Proximal lesions in 120 extracted human teeth with ICDAS-2 (n = 30), 3 (n = 45) and 5 (n = 45) lesions were etched with 15% hydrochloric acid gel for 2 min and allocated to one of the following treatments; IR: lesions (ICDAS-2, 3 and 5; each n = 15) were treated with commercial infiltrant resin for 3 min...
May 16, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29742254/effects-of-three-silane-primers-and-five-adhesive-agents-on-the-bond-strength-of-composite-material-for-a-computer-aided-design-and-manufacturing-system
#4
Ayano Shinohara, Yohsuke Taira, Michino Sakihara, Takashi Sawase
Objective The objective of this study was to evaluate the effects of combinations of silane primers and adhesive agents on the bond strength of a composite block for a computer-aided design and manufacturing system. Material and Methods Three silane primers [Clearfil Ceramic Primer (CP), Super-Bond PZ Primer (PZ), and GC Ceramic Primer II (GP)] were used in conjunction with five adhesive agents [G-Premio Bond (P-Bond), Repair Adhe Adhesive (R-Adhesive), Super-Bond D-Liner Dual (SB-Dual), Super-Bond C&B (SB-Self), and SB-Dual without tributylborane derivative (SB-Light)]...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29742232/can-low-fusing-glass-application-affect-the-marginal-misfit-and-bond-strength-of-y-tzp-crowns
#5
Monize Carelli Felipe Antunes, Jean Soares Miranda, Ronaldo Luís Almeida de Carvalho, Rodrigo Furtado de Carvalho, Estevão Tomomitsu Kimpara, Rodrigo Othávio de Assunção E Souza, Fabíola Pessôa Pereira Leite
To evaluate the effect of different surface treatments on the marginal misfit and retentive strength between Y-TZP crowns and an epoxy resin. Forty (40) epoxy resin (G10) abutments (height: 5mm, conicity: 60, finish line: large chamfer) with equal dimensions were milled and included in polyurethane to simulate the periodontal ligament. Next, 40 Y-TZP crowns (thickness: 1mm) were milled (Cerec in Lab) and randomly divided into four groups (n=10) according to the surface treatment: GS(glaze spray), GP(glaze powder/liquid), P(zirconia primer) and RS(tribochemical silica coating)...
2018: Brazilian Oral Research
https://www.readbyqxmd.com/read/29728541/assessment-of-fracture-resistance-capacity-of-different-core-materials-with-porcelain-fused-to-metal-crown-an-in-vitro-study
#6
Rajesh Vyas, S R Suchitra, Prafulla T Gaikwad, Vishwanath Gurumurthy, Suraj Arora, Shashit Shetty
Aim: The aim of the study was to evaluate the capacity to resist fracture in different core buildup materials with porcelain fused to metal (PFM) crown. Materials and methods: Totally, 45 mandibular single rooted first premolars were collected, which were sound along with similar shape and size. The teeth were sectioned at 15 mm above the root apex sparing the sound tooth structure. The teeth were endodontically treated with the crown-down technique using nickel-titanium (NiTi) instrumentation. The specimens were randomized into three groups as per the core materials used and were labeled accordingly...
April 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29722264/anti-egfr-peptide-conjugated-triangular-gold-nanoplates-for-computed-tomography-photoacoustic-imaging-guided-photothermal-therapy-of-non-small-cell-lung-cancer
#7
Ying Zhao, Wenfei Liu, Ying Tian, ZhenLu Yang, Xiaofen Wang, Yunlei Zhang, Yuxia Tang, Shuang Zhao, Chunyan Wang, Ying Liu, Jing Sun, Zhaogang Teng, Shouju Wang, Guangming Lu
Non-small cell lung cancer (NSCLC) is difficult to cure since the high recurrence rate and the side effects of current treatments. It is urgent to develop a new treatment that is safer and more effective than current treatments against NSCLC. Herein, we constructed anti-EGFR peptide conjugated PEGylated triangular gold nanoplates (TGN-PEG-P75) as a targeting photothermal therapy (PTT) agent to treat NSCLC under the guidance of computed tomography (CT) and photoacoustic imaging (PAI). The surface of TGNs is successfully conjugated with a novel peptide P75 that has the specific affinity with epidermal growth factor receptor (EGFR)...
May 3, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29709240/hygroscopic-expansion-of-self-adhesive-resin-cements-and-the-integrity-of-all-ceramic-crowns
#8
Magdalena Kirsten, Ragai Edward Matta, Renan Belli, Ulrich Lohbauer, Manfred Wichmann, Anselm Petschelt, José Zorzin
OBJECTIVE: Low pH neutralization and subsequent remnant hydrophilicity can lead to hygroscopic expansion of self-adhesive resin cements (SARCs) after water storage. The aim of this in vitro study was to investigate the effects of hygroscopic expansion of SARCs, used as luting and partial core build-up material, on integrity and cement gap thickness increase of all-ceramic CAD/CAM crowns. METHODS: Human third molars (n=48) were prepared and anatomical all-ceramic CAD/CAM crowns were manufactured (VITABLOCS Mark II, VITA Zahnfabrik)...
April 27, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29699512/regulation-of-calretinin-in-malignant-mesothelioma-is-mediated-by-septin-7-binding-to-the-calb2-promoter
#9
Walter Blum, László Pecze, Janine Wörthmüller Rodriguez, Martine Steinauer, Beat Schwaller
BACKGROUND: The calcium-binding protein calretinin (gene name: CALB2) is currently considered as the most sensitive and specific marker for the diagnosis of malignant mesothelioma (MM). MM is a very aggressive tumor strongly linked to asbestos exposure and with no existing cure so far. The mechanisms of calretinin regulation, as well as its distinct function in MM are still poorly understood. METHODS: We searched for transcription factors binding to the CALB2 promoter and modulating calretinin expression...
April 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29696736/bismuth-improves-efficacy-of-proton-pump-inhibitor-clarithromycin-metronidazole-triple-helicobacter-pylori-therapy-despite-a-high-prevalence-of-antimicrobial-resistance
#10
Xiaohua Long, Qi Chen, Lou Yu, Xiao Liang, Wenzhong Liu, Hong Lu
BACKGROUND: Helicobacter pylori (H. pylori) eradication has become increasingly difficult especially for penicillin allergy patients. AIMS: To evaluate the efficacy of adding bismuth or high-dose metronidazole to an H. pylori eradication regimen containing a proton-pump inhibitor, clarithromycin, and metronidazole in patients allergic to penicillin. METHODS: Pilot study in which penicillin-allergic, treatment-naive subjects were randomized (1:1) to 14-day esomeprazole (20 mg q12h), clarithromycin (500 mg q12h), and high dose of metronidazole (400 mg q6h) with (BECM group) or without (ECM group) bismuth (600 mg q12h)...
April 25, 2018: Helicobacter
https://www.readbyqxmd.com/read/29670735/microleakage-of-porcelain-laminate-veneers-cemented-with-different-bonding-techniques
#11
Satheesh B Haralur
Background: Porcelain laminate veneers (PLV) are continued to be popular in modern dental practice due to its high aesthetic outcome and conservative tooth preparation. The composite resins are commonly used as luting agents for cementation of PLV. Polymerisation shrinkage induced marginal gap and interfacial leakage is the persistent limitation with the resin luting cements. The objective of the study was to assess the effect of various dentin bonding techniques on the microleakage after accelerated ageing in porcelain laminate veneres...
February 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29657518/influence-of-light-activation-of-simplified-adhesives-on-the-shear-bond-strength-of-resin-cements-to-a-leucite-reinforced-ceramic
#12
Adilson Yoshio Furuse, Cassiana Koch Scotti, Alfredo Llerena-Icochea, Juliana Fraga Soares Bombonatti, Gisele Aihara Haragushiku, Carla Castiglia Gonzaga
Objective: This study aims to evaluate the influence of the light activation of simplified adhesives on the shear bond strength of resin cements to a glass-ceramic. Three factors were evaluated: (1) cement in two levels (light cured and dual cured); (2) adhesive in two levels (Single Bond 2 and Single Bond Universal), and (3) light activation in two levels (yes or no). Materials and Methods: Thirty-two 1-mm thick slices of a leucite-reinforced glass-ceramic (IPS Empress CAD) were divided into eight groups according to adhesive (Single Bond 2 or Single Bond Universal), cement (AllCem Veneer or AllCem), and light activation of the adhesive before application of the cement (yes or no)...
January 2018: European Journal of Dentistry
https://www.readbyqxmd.com/read/29653177/additive-potential-of-combination-therapy-against-cryptococcosis-employing-a-novel-amphotericin-b-and-fluconazole-loaded-dual-delivery-system
#13
Azmat Ali Khan, Amer M Alanazi, Mumtaz Jabeen, Shahnavaj Khan, Abdul Mallik
Cryptococcus neoformans is one of the most lethal fungi causing mortality across the globe with the highest incidences in immuno-compromised person. Patients taking immuno-suppressive medications and immuno-competent hosts are extremely susceptible to its infection. Thus, new forms of therapy are urgently required for effective cure to the fungal burden. So, in the present study we have tried to explore the potential effects of amphotericin B (AMB) and fluconazole (FLC) in combination antifungal drug therapy...
April 10, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29643233/hematopoietic-stem-cell-transplantation-in-its-60s-a-platform-for-cellular-therapies
#14
REVIEW
Christian Chabannon, Jurgen Kuball, Attilio Bondanza, Francesco Dazzi, Paolo Pedrazzoli, Antoine Toubert, Annalisa Ruggeri, Katharina Fleischhauer, Chiara Bonini
Over the last 60 years, more than a million patients received hematopoietic cell transplantation. Having incorporated multiple changes in clinical practices, it remains a complex procedure facing a dual challenge: cure of the underlying disease and prevention of relapse while controlling potentially severe complications. Improved understanding of underlying biological processes resulted in the design of innovative therapies engineered from defined cell populations and testing of these therapies as addition or substitution at virtually every step of the procedure...
April 11, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29628652/development-of-a-dual-cure-mineral-trioxide-aggregate-based-cement-biological-physical-and-mechanical-properties
#15
Laura Siqueira Pintado, Eliana do Nascimento Torre, Maicon Dos Santos Selayaran, Rodrigo Varella de Carvalho, Cesar Henrique Zanchi, Fábio Renato Manzolli Leite, Adriana Etges
Purpose: The purpose of this study is to compare the physical, mechanical, and biocompatibility properties of a new dual-cure white mineral trioxide aggregate (D-W-MTA) and a commercial W-MTA. Materials and Methods: Diametral tensile strength (DTS), water sorption (WSp), and water solubility (WSl) tests were performed. Cytotoxicity was observed in primary culture of human pulp fibroblasts (HPFs) and mouse 3T3/NIH fibroblast lineage. Specimens of both materials were embedded in 1 mL of Dulbecco's modified essential medium for 24 h...
January 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29628647/evaluation-of-degree-of-conversion-and-the-effect-of-thermal-aging-on-the-color-stability-of-resin-cements-and-flowable-composite
#16
Lúcia Trazzi Prieto, Cíntia Tereza Pimenta de Araújo, Josué Junior Araujo Pierote, Dayane Carvalho Ramos Salles de Oliveira, Erick Kamiya Coppini, Luís Alexandre Maffei Sartini Paulillo
Purpose: The aim of this in vitro study was to evaluate the color stability and degree of conversion (DC) of dual-cure and light-cure cements and flowable composites after thermal aging. Materials and Methods: A total of 50 human incisors were prepared and divided into six groups ( n = 10). Veneers were fabricated using IPS Empress Direct composite resin were bonded with three types of luting agents: Light-cured, conventional dual, and flowable composite according to the manufacturer's instructions...
January 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29587429/plant-derived-anticancer-agents-lessons-from-the-pharmacology-of-geniposide-and-its-aglycone-genipin
#17
REVIEW
Solomon Habtemariam, Giovanni Lentini
For centuries, plants have been exploited by mankind as sources of numerous cancer chemotherapeutic agents. Good examples of anticancer compounds of clinical significance today include the taxanes (e.g., taxol), vincristine, vinblastine, and the podophyllotoxin analogues that all trace their origin to higher plants. While all these drugs, along with the various other available therapeutic options, brought some relief in cancer management, a real breakthrough or cure has not yet been achieved. This critical review is a reflection on the lessons learnt from decades of research on the iridoid glycoside geniposide and its aglycone, genipin, which are currently used as gold standard reference compounds in cancer studies...
March 26, 2018: Biomedicines
https://www.readbyqxmd.com/read/29556256/spinal-muscular-atrophy-type-i-and-the-dual-role-of-viruses-an-interview-with-professor-basil-t-darras-professor-of-neurology-pediatrics-at-harvard-medical-school
#18
Ioannis N Mammas, Demetrios A Spandidos
According to Professor Basil T. Darras, Professor of Neurology (Pediatrics) at Harvard Medical School and Director of the Spinal Muscular Atrophy (SMA) Program at Boston Children's Hospital in Boston (MA, USA), the diagnosis of SMA type I is clinical and is based on detailed general physical and neurological examinations. SMA type I remains the most common genetic disease resulting in death in infancy and is really devastating for the child, the parents, as well as the medical professionals with the privilege of caring for patients with SMA and their parents...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29551659/da5-ch-a-novel-glp-1-gip-dual-agonist-effectively-ameliorates-the-cognitive-impairments-and-pathology-in-the-app-ps1-mouse-model-of-alzheimer-s-disease
#19
Yue Cao, Christian Hölscher, Meng-Ming Hu, Ting Wang, Fang Zhao, Yu Bai, Jun Zhang, Mei-Na Wu, Jin-Shun Qi
Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which there is no cure. The early primary symptom of AD is the decline of memory ability, which gradually develops into complete dementia. Type 2 diabetes mellitus (T2DM) is an important risk factor of AD; and mimetics of the incretin hormone GLP-1 developed to treat diabetes are being tested as a novel therapeutic strategy for AD. In the present study, we reported for the first time the neuroprotective effects of a novel GLP-1/GIP dual agonist DA5-CH that activates the incretin hormone GLP-1 and GIP receptors in the APP/PS1 transgenic AD mouse model...
May 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29530658/systemic-antibiotics-for-the-treatment-of-skin-and-soft-tissue-abscesses-a-systematic-review-and-meta-analysis
#20
REVIEW
Michael Gottlieb, Joshua M DeMott, Marilyn Hallock, Gary D Peksa
STUDY OBJECTIVE: The addition of antibiotics to standard incision and drainage is controversial, with earlier studies demonstrating no significant benefit. However, 2 large, multicenter trials have recently been published that have challenged the previous literature. The goal of this review was to determine whether systemic antibiotics for abscesses after incision and drainage improve cure rates. METHODS: PubMed, the Cumulative Index of Nursing and Allied Health Literature, Scopus, the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials, and bibliographies of selected articles were assessed for all randomized controlled trials comparing adjuvant antibiotics with placebo in the treatment of drained abscesses, with an outcome of treatment failure assessed within 21 days...
March 9, 2018: Annals of Emergency Medicine
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