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https://www.readbyqxmd.com/read/29152620/efficacy-of-a-universal-adhesive-in-the-bond-strength-of-composite-cements-to-polymer-infiltrated-ceramic
#1
Nadja Rohr, Alba Flury, Jens Fischer
PURPOSE: To investigate the effect of a universal adhesive on the bond strength of composite cements to a polymer- infiltrated ceramic network. MATERIALS AND METHODS: Shear bond strength to a polymer-infiltrated ceramic network (Vita Enamic) and to its polymer and ceramic components was assessed on polished surfaces using either a conventional dual-curing resin (RelyX Ultimate) or self-adhesive composite cement (RelyX Unicem 2 Automix). Substrate surfaces were either not pretreated or a silane coupling agent (Vitasil), a universal adhesive (Scotchbond Universal Adhesive), or both were applied...
November 17, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/29152618/effect-of-mechanical-fatigue-on-the-bond-between-zirconia-and-composite-cement
#2
Hugo A Vidotti, Ricardo M Carvalho, Paulo G Coelho, Willian F Zambuzzi, Gerson Bonfante, Accácio L do Valle, Estevam A Bonfante
PURPOSE: To examine the effect of mechanical fatigue on the bond strength of resin composite cemented to silicacoated yttria-tetragonal zirconia polycrystal ceramic (Y-TZP). MATERIALS AND METHODS: Ten Y-TZP blocks were polished down to 600-grit silicon carbide paper. Specimens were silica coated by airborne-particle abrasion with 30-μm silica-modified Al2O3 particles. Blocks were cleaned in an ultrasonic bath, and a dental adhesive was applied and light cured for 20 s...
November 17, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/29145150/microrna-146a-knockdown-suppresses-the-progression-of-ankylosing-spondylitis-by-targeting-dickkopf-1
#3
Guijuan Di, Lingli Kong, Qing Zhao, Tao Ding
Ankylosing spondylitis (AS) seriously threatens healthy and life quality of patients, however, there is no extremely effective drug to cure the disease. Therefore, it is urgent to understand molecular basis in the progression of AS. MicroRNA-146a (miR-146a) has been demonstrated to be associated with the development of AS. However, its molecular mechanism has not been fully established. In this study, it is found that the expression levels of miR-146a and dickkopf 1 (DKK1) were respectively upregulated and downregulated in hip capsule tissues of AS patients...
November 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29140523/sequential-coiling-assisted-deployment-of-flow-diverter-for-treatment-of-fusiform-middle-cerebral-artery-aneurysms
#4
Abdulrahman Y Alturki, Philip G R Schmalz, Christopher S Ogilvy, Ajith J Thomas
BACKGROUND AND IMPORTANCE: Fusiform intracranial aneurysms remain challenging lesions to treat. These aneurysms have historically required bypass procedures or clip remodeling constructs for cure. Recently, endovascular specialists have reported experience with flow diversion for complex fusiform aneurysms of the vertebrobasilar system, with mixed results. Vascular anatomy for anterior circulation fusiform aneurysms may make these lesions more amenable to flow diversion and embolization procedures; however, published experience with these techniques is lacking...
November 11, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29120617/live-visualization-of-hiv-1-proviral-dna-using-a-dual-color-labeled-crispr-system
#5
Yingxin Ma, Mingxiu Wang, Wei Li, Zhi-Ping Zhang, Xiaowei Zhang, Tianwei Tan, Zongqiang Cui, Xian-En Zhang
HIV latency is one of the major problems in HIV/AIDS cure. Imaging single-copy integrated proviral HIV DNA in host cell has both virology and clinical significance but remains technical challenge. Here, we developed a dual-color labeled CRISPR system to image the HIV-1 integrated proviral DNA in latently infected cells. The pair of CRISPRs was fluorescently labeled with two different color QDs using two alternative bioorthogonal ligation reactions. Integrated HIV-sequences are successfully mapped based on the co-localized signals of QDs in living cells...
November 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29115209/exploring-the-use-of-ingenol-mebutate-to-prevent-non-melanoma-skin-cancer
#6
Andrés Már Erlendsson
Non-melanoma skin cancer is the most frequently occurring cancer in Caucasians today. Incidence rates in Europe have increased steadily since the 1960s and more than tripled over the last 50 years. Despite primary preventative efforts, incidences of non-melanoma skin cancer continue to rise and development of effective chemopreventative strategies is needed. In 2013, ingenol mebutate was approved in Denmark as a new topical drug for field-directed treatment for actinic keratoses. Ingenol mebutate has a dual mechanism of action, causing initial cell death, followed by an immune activation...
November 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29099373/fluorination-of-zirconia-surfaces-impairs-bonding-to-resin-cement
#7
Leandro Tolomelli Carraro Franco, Marina Amaral, Rafael Pino Vitti, Alecsandro Moura Silva, Laís Regiane Silva-Concílio, Ana Christina Claro Neves
The aim of this study was to evaluate the fluorination of a zirconia surface as an alternative treatment for bonding to resin cement; the null hypothesis was that fluorination would not improve adhesion values. Four different surface treatments were performed on the surface of yttria-stabilized tetragonal zirconia polycrystal discs (N = 80): Ctrl (control), no treatment; SB, sandblasting with 50-μm alumina particles; SBS, sandblasting with 30-μm silica-modified alumina particles and application of silane; and SF, fluorination with sulfur hexafluoride-containing plasma...
November 2017: General Dentistry
https://www.readbyqxmd.com/read/29098160/micro-raman-vibrational-identification-of-10-mdp-bond-to-zirconia-and-shear-bond-strength-analysis
#8
Diego Martins De-Paula, Alessandro D Loguercio, Alessandra Reis, Natasha Marques Frota, Radamés Melo, Kumiko Yoshihara, Victor Pinheiro Feitosa
So far, there is no report regarding the micro-Raman vibrational fingerprint of the bonds between 10-methacryloyloxy-decyl dihydrogen phosphate (10-MDP) and zirconia ceramics. Thus, the aim of this study was to identify the Raman vibrational peaks related to the bonds of 10-MDP with zirconia, as well as the influence on microshear bond strength. Micro-Raman spectroscopy was employed to assess the vibrational peak of 10-MDP binding to zirconia. Microshear bond strength of the dual-cure resin cement to zirconia with the presence of 10-MDP in composition of experimental ceramic primer and self-adhesive resin cement was also surveyed...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29094477/rescue-therapy-with-bismuth-quadruple-regimen-in-patients-with-helicobacter-pylori-resistant-strains
#9
Giulia Fiorini, Ilaria Maria Saracino, Angelo Zullo, Luigi Gatta, Matteo Pavoni, Dino Vaira
BACKGROUND: Bismuth quadruple therapy (BQT) is the recommended rescue therapy for Helicobacter pylori (H. pylori) infection. This study aimed to assess the efficacy and safety of a 10-day BQT regimen in patients who failed previous therapies and were infected with multiresistant H. pylori strains MATERIALS AND METHODS: Helicobacter pylori-infected patients underwent endoscopy, culture, and susceptibility test for clarithromycin, metronidazole, and levofloxacin. Treatment with three-in-one capsule (Pylera®) four times daily and esomeprazole 20 mg twice daily for 10 days was administered...
November 1, 2017: Helicobacter
https://www.readbyqxmd.com/read/29083086/polymerization-shrinkage-and-porosity-profile-of-dual-cure-dental-resin-cements-with-different-adhesion-to-dentin-mechanisms
#10
Adrieli Burey, Paulo José Dos Reis, Bruno Luiz Santana Vicentin, Cássia Cilene Dezan Garbelini, Márcio Grama Hoeppner, Carlos Roberto Appoloni
This research aims to probe the porosity profile and polymerization shrinkage of two different dual cure resin cements with different dentin bonding systems. The self-adhesive resin cement RelyX U200 (named RU) and the conventional Allcem Core (named AC) were analyzed by x-ray microtomography (μCT) and Scanning Electron Microscopy (SEM). Each cement was divided into two groups (n = 5): dual-cured (RUD and ACD) and self-cured (RUC and ACC). μCT demonstrated that the method of polymerization does not influence the porosity profile but the polymerization shrinkage...
October 30, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29046593/wavelength-selective-sequential-polymer-network-formation-controlled-with-a-two-color-responsive-initiation-system
#11
Xinpeng Zhang, Weixian Xi, Sijia Huang, Katelyn Long, Christopher N Bowman
We report a wavelength-selective polymerization process controlled by visible/UV light, whereby a base is generated for anion-mediated thiol-Michael polymerization reaction upon exposure at one wavelength (400-500 nm), while radicals are subsequently generated for a second stage radical polymerization at a second, independent wavelength (365 nm). Dual wavelength, light controlled sequential polymerization not only provides a relatively soft intermediate polymer that facilitates optimum processing and modification under visible light exposure but also enables a highly cross-linked, rigid final material after the UV-induced second stage radical polymerization...
August 8, 2017: Macromolecules
https://www.readbyqxmd.com/read/29016985/the-effect-of-various-adhesives-enamel-etching-and-base-treatment-on-the-failure-frequency-of-customized-lingual-brackets-a-randomized-clinical-trial
#12
Dimitrios Mavreas, Jean-François Cuzin, Guillaume Boonen, Bart Vande Vannet
Objectives: The aim of this paper was to compare failure differences in precious metal customized lingual brackets bonded with three adhesive systems. Also, differences in failure of non-precious metal brackets with and without a silicatized base layer bonded with the same adhesive, as well as the influence of enamel etching prior to using a self-etching dual cure resin were explored. Materials/methods: Five different groups were defined in a semi-randomized approach...
July 10, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28988143/fatigue-failure-load-of-zirconia-reinforced-lithium-silicate-glass-ceramic-cemented-to-a-dentin-analogue-effect-of-etching-time-and-hydrofluoric-acid-concentration
#13
Jaiane Bandoli Monteiro, Marcelo Gallo Oliani, Luis Felipe Guilardi, Catina Prochnow, Gabriel Kalil Rocha Pereira, Marco Antonio Bottino, Renata Marques de Melo, Luiz Felipe Valandro
This study aimed to evaluate the effect of etching time and hydrofluoric acid (HF) concentration on the fatigue failure load and surface characteristics of zirconia-reinforced lithium silicate glass (ZLS) ceramic cemented to a dentin-like, fiber reinforced epoxy resin. Ceramic (Suprinity, VITA) (1.0mm thick) and epoxy resin (2.5mm thick) discs (10mm diameter) were produced. The bonding surface of the ceramic samples was nonetched (control group), or etched for 30, 60 or 90s by 5% or 10% HF. The epoxy resin discs were etched by 10% HF for 30s followed by the application of an adhesive material (Single Bond Universal, 3M ESPE)...
September 23, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28983675/efficacy-and-safety-of-sofosbuvir-plus-ribavirin-for-treatment-of-cirrhotic-patients-with-genotype-4-hepatitis-c-virus-in-real-life-clinical-practice
#14
Sherief Abd-Elsalam, Mohamed Sharaf-Eldin, Shaimaa Soliman, Asem Elfert, Rehab Badawi, Youssef K Ahmad
Egypt has the highest hepatitis C virus (HCV) prevalence in the world. Sofosbuvir is a new highly effective drug for treatment of HCV infection. Compared to previous treatments, sofosbuvir-based regimens provide a higher cure rate, fewer side effects, and a two- to fourfold reduced duration of therapy. The aim of this study was to evaluate the antiviral efficacy, safety, and tolerability of sofosbuvir plus ribavirin in Egyptian patients with liver cirrhosis due to chronic HCV infection. We studied 2400 cirrhotic Egyptian patients with chronic HCV infection who were treated with dual therapy with sofosbuvir and ribavirin for 24 weeks...
October 5, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28975170/thiol-ene-epoxy-thermoset-for-low-temperature-bonding-to-biofunctionalized-microarray-surfaces
#15
Xiamo C Zhou, Ronald Sjöberg, Amaury Druet, Jochen M Schwenk, Wouter van der Wijngaart, Tommy Haraldsson, Carl Fredrik Carlborg
One way to improve the sensitivity and throughput of miniaturized biomolecular assays is to integrate microfluidics to enhance the transport efficiency of biomolecules to the reaction sites. Such microfluidic integration requires bonding of a prefabricated microfluidic gasket to an assay surface without destroying its biological activity. In this paper we address the largely unmet challenge to accomplish a proper seal between a microfluidic gasket and a protein surface, with maintained biological activity and without contaminating the surface or blocking the microfluidic channels...
October 25, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28971656/-should-patients-with-primary-hyperparathyroidism-and-negative-imaging-studies-be-referred-to-surgery
#16
Michal Mekel, Barak Levit, Yoram Kluger, Sophia Ish-Shalom, Elena Segal, Bishara Bishara
INTRODUCTION: Parathyroidectomy is the only curative treatment for primary hyperparathyroidism (PHPT). In cases where imaging fails to demonstrate an adenoma, a bilateral neck exploration (BNE) is performed. Negative imaging is thought to predict surgical failure, and patients with negative imaging are often not referred for surgery. These patients are at risk for disease progression. AIMS: Evaluate the effect of negative imaging on surgical findings and the cure rate in patients with PHPT...
September 2017: Harefuah
https://www.readbyqxmd.com/read/28951561/dual-inhibition-of-ezh1-2-breaks-the-quiescence-of-leukemia-stem-cells-in-acute-myeloid-leukemia
#17
S Fujita, D Honma, N Adachi, K Araki, Ei Takamatsu, T Katsumoto, K Yamagata, K Akashi, K Aoyama, A Iwama, I Kitabayashi
Acute myeloid leukemia (AML) is an aggressive and lethal blood cancer originating from rare populations of leukemia stem cells (LSCs). AML relapse after conventional chemotherapy is caused by a remaining population of drug-resistant LSCs. Selective targeting of the chemo-resistant population is a promising strategy for preventing and treating AML relapse. Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27 to maintain the stemness of LSCs. Here, we show that quiescent LSCs expressed the highest levels of enhancer of zeste (EZH) 1 and EZH2, the PRC2 catalytic subunits, in the AML hierarchy, and that dual inactivation of EZH1/2 eradicated quiescent LSCs to cure AML...
September 27, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28946486/udm-enhanced-physical-and-mechanical-properties-through-the-formation-of-nanocavities-in-an-epoxy-matrix
#18
Kaushal Kumar, Arun Kumar, P K Ghosh
The matrix modification of relatively low viscous epoxy based polymer treated under ultrasonic mixing (UM) and ultrasonic mixing with simultaneous stirring by a rotating impeller, referred to as ultrasonic dual mixing (UDM), and the effect of processing techniques has been investigated in terms of the formation of nanocavities in the epoxy matrix. Nanocavities of size 42±8nm have been formed uniformly in the epoxy matrix by UDM. The effect of a change in matrix morphology on the viscoelastic, tensile and thermal properties of the cured epoxy resin has been studied...
January 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28945802/hbv-core-protein-allosteric-modulators-differentially-alter-cccdna-biosynthesis-from-de-novo-infection-and-intracellular-amplification-pathways
#19
Fang Guo, Qiong Zhao, Muhammad Sheraz, Junjun Cheng, Yonghe Qi, Qing Su, Andrea Cuconati, Lai Wei, Yanming Du, Wenhui Li, Jinhong Chang, Ju-Tao Guo
Hepatitis B virus (HBV) core protein assembles viral pre-genomic (pg) RNA and DNA polymerase into nucleocapsids for reverse transcriptional DNA replication to take place. Several chemotypes of small molecules, including heteroaryldihydropyrimidines (HAPs) and sulfamoylbenzamides (SBAs), have been discovered to allosterically modulate core protein structure and consequentially alter the kinetics and pathway of core protein assembly, resulting in formation of irregularly-shaped core protein aggregates or "empty" capsids devoid of pre-genomic RNA and viral DNA polymerase...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28938165/a-novel-dopa-albumin-based-tissue-adhesive-for-internal-medical-applications
#20
Wenzhen Zhu, Yvonne Peck, Jabed Iqbal, Dong-An Wang
To date, existing tissue adhesives have various weak points in gluing kinetics and stability - particularly, in biocompatibility, which make most of them remain suboptimal for internal conditions. Herein, a novel mussel-inspired "BCD" tissue glue made of bovine serum albumin (BSA), citrate acid (CA) and dopamine was developed aiming at internal medical applications. BSA was employed as a natural and biocompatible macromolecular backbone; CA was introduced as a dual-functional intermediate to increase reactive carboxyl sites for engraftment of dopamine onto BSA backbone and also block the competing reactive amines from the proteinic backbone...
September 14, 2017: Biomaterials
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