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https://www.readbyqxmd.com/read/28209008/effect-of-resin-bonded-luting-agents-influencing-marginal-discrepancy-in-all-ceramic-complete-veneer-crowns
#1
Dhanraj Ganapathy, Anusha Sathyamoorthy, Hemalatha Ranganathan, Karthikeyan Murthykumar
INTRODUCTION: Marginal discrepancy severely affects the long term success of All ceramic complete veneer crowns. The precise role of resin luting agents influencing this phenomenon needs to be explored further. AIM: To estimate and compare the marginal discrepancy in CAD/CAM processed All ceramic complete veneer crowns prior and following luting with resin bonded luting agents. MATERIALS AND METHODS: Extracted human maxillary first premolars were randomly allocated into four groups of 27 samples each Viz...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28203013/-curing-mode-of-universal-adhesives-affects-the-bond-strength-of-resin-cements-to-dentin
#2
Z R Fu, F C Tian, L Zhang, B Han, X Y Wang
OBJECTIVE: To determine the effects of curing mode of one-step and two-step universal adhesives on the micro-tensile bond strength (μTBS) of different dual-cure resin cements to dentin. METHODS: One-step universal adhesive Single Bond Universal (SBU), and two-step universal adhesive OptiBond Versa (VSA) were chosen as the subjects, one-step self-etching adhesive OptiBond All in One (AIO) and two-step self-etching adhesive Clearfil SE Bond (SEB) were control groups, and two dual-cure resin cements RelyX Ultimate (RLX) and Nexus 3 Universal (NX3) were used in this study...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28198977/degree-of-conversion-and-bond-strength-of-resin-cements-to-feldspathic-ceramic-using-different-curing-modes
#3
Veridiana Resende Novais, Luís Henrique Araújo Raposo, Rafael Resende de Miranda, Camila de Carvalho Almança Lopes, Paulo Cézar Simamoto, Carlos José Soares
Objective: The aim of this study was to assess the performance of resin cements when different curing modes are used, by evaluating the degree of conversion and bond strength to a ceramic substrate. Material and Methods: Three resin cements were evaluated, two dual-cured (Variolink II and RelyX ARC) and one light-cured (Variolink Veneer). The dual-cured resin cements were tested by using the dual activation mode (base and catalyst) and light-activation mode (base paste only)...
January 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28195276/an-experimental-thermally-deposited-coating-for-improved-bonding-to-glass-fiber-posts
#4
Giselle Rodrigues Reis, Fernanda Pereira Silva, Aline Oliveira-Ogliari, André Luis Faria-E-Silva, Rafael R Moraes, Veridiana Resende Novais, Murilo de Sousa Menezes
PURPOSE: To determine whether an experimental thermally deposited siloxane-methacrylate coating for use in industrial scale applications would improve the bond strength of resin-based materials to glass fiber posts (GFPs) without affecting their mechanical properties. MATERIALS AND METHODS: An experimental 5% (w/v) solution of methacryloxypropyltrimethoxysilane was prepared. Two types of GFPs (Exacto, Angelus; White Post DC, FGM) were divided into the following groups: S: silane; SA: silane and adhesive; HS: 35% H₂O₂ and silane; HSA: 35% H₂O₂, silane and adhesive; Exp: siloxane-methacrylate coating (Si-O) via post immersion in experimental solution followed by heating; Exp-S: silane after Si-O treatment; Exp-A: adhesive after Si-O treatment; and Exp-SA: silane and adhesive after Si-O treatment...
February 10, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28195273/light-transmission-of-novel-cad-cam-materials-and-their-influence-on-the-degree-of-conversion-of-a-dualcuring-resin-cement
#5
Ferhan Egilmez, Gulfem Ergun, Isil Cekic-Nagas, Pekka K Vallittu, Lippo V J Lassila
PURPOSE: To evaluate the light transmission characteristics of different types, shades, and thicknesses of novel CAD/CAM materials and their effect on the degree of conversion (DC) of a dual-curing resin cement. MATERIALS AND METHODS: Square specimens (12 × 12 mm2) of three CAD/CAM materials - GC Cerasmart, Lava Ultimate, Vita Enamic - of different thicknesses (1.00, 1.50, and 2.00 mm, n = 5 per thickness) were irradiated with an LED unit. The amount of transmitted light was quantified...
February 10, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28183626/stavudine-loaded-gelatin-liposomes-for-hiv-therapy-preparation-characterization-and-in-vitro-cytotoxic-evaluation
#6
Debasis Nayak, Ankita Boxi, Sarbani Ashe, Neethi Chandra Thathapudi, Bismita Nayak
Despite continuous research and availability of 25 different active compounds for treating chronic HIV-1 infection, there is no absolute cure for this deadly disease. Primarily, the residual viremia remains hidden in latently infected reservoir sites and persistently release the viral RNA into the blood stream. The study proposes the dual utilization of the prepared stavudine-containing nanoformulations to control the residual viremia as well as target the reservoir sites. Gelatin nanoformulations containing very low dosage of stavudine were prepared through classical desolvation process and were later loaded in soya lecithin-liposomes...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28174008/setting-characteristics-and-mechanical-properties-of-self-adhesive-resin-luting-agents
#7
Raphael Pilo, Dimitris Papadogiannis, Spiros Zinelis, George Eliades
OBJECTIVE: To evaluate the degree of conversion (DC%), salt yield and mechanical properties of self-adhesive luting agents (SAA) set under dual-cure (E) and self-cure (NE) modes. METHODS: Three SAA (GC LinkAce/GCLA, MaxCem Elite/MXEL, Rely-X Unicem 2/RXUN) and an adhesive resin luting agent (Rely-X Ultimate/RXUL-control) were used. The properties tested under E and NE modes were a) DC% and phosphate salt yield after 10min, 1h (h) and 3 weeks (w) storage, by infrared spectroscopy; and b) the mechanical properties of 3w-stored specimens by instrumented indentation testing (Martens hardness/HM, Elastic modulus/EIT, Elastic index/ηIT) and microscopic Vickers hardness/VH...
February 4, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28149471/bond-strength-of-adhesive-resin-cement-with-different-adhesive-systems
#8
Fabrizio Lorenzoni E Silva, Saulo Pamato, Milton-Carlos Kuga, Marcus-Vinicius-Reis Só, Jefferson-Ricardo Pereira
BACKGROUND: To assess the immediate bond strength of a dual-cure adhesive resin cement to the hybridized dentin with different bonding systems. MATERIAL AND METHODS: Fifty-six healthy human molars were randomly divided into 7 groups (n=8). After 3 longitudinal sections, the central cuts were included in PVC matrix and were submitted to dentin hybridization according to the groups: G1 - etch & rinse system with 3-step (Apder™ Scotchbond™ Multi-Purpose, 3M ESPE), G2 - etch & rinse system with 3-step (Optibond™ FL, Kerr), G3 - etch & rinse system with 3-step (All-Bond 3®, Bisco), G4 - etch & rinse simplified system (Adper™ Single Bond 2, 3M ESPE), G5 - self-etching system with one step (Bond Force, Tokuyama), G6 - universal system in moist dentin (Single Bond Universal, 3M ESPE), G7 - universal system in dry dentin (Single Bond Universal, 3M ESPE)...
January 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28126243/the-effect-of-curing-conditions-on-the-dentin-bond-strength-of-two-dual-cure-resin-cements
#9
Atsuko Tagami, Rena Takahashi, Toru Nikaido, Junji Tagami
PURPOSE: The purpose of this study was to determine the effect of the curing condition (i.e., the curing mode and restoration thickness) on the tensile bond strength of a dual-cure resin cement applied to dentin. METHODS: Indirect composite resin disks (1, 2, and 3mm in thickness) were prepared. The irradiance of a halogen light curing unit through each disk was measured by a curing radiometer. A measurement was also taken for the condition with no disk. Following this, two dual-cure resin cements, Panavia F2...
January 23, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28118929/effects-of-two-grading-techniques-of-zirconia-material-on-the-fatigue-limit-of-full-contour-3-unit-fixed-dental-prostheses
#10
Regina Furbino Villefort, Marina Amaral, Gabriel Kalil Rocha Pereira, Tiago Moreira Bastos Campos, Yu Zhang, Marco Antonio Bottino, Luiz Felipe Valandro, Renata Marques de Melo
OBJECTIVE: This study evaluated the effects of two grading techniques of zirconia material on the fatigue limit of full-contour 3-unit fixed dental prostheses (FDPs). METHODS: Presintered blocks of 3Y-TZP were milled to obtain sixty-nine 3-unit FDPs, which were divided into three groups (n=23). The control group (CTL) was sintered and glazed following manufacturer's instructions. In the two experimental groups presintered FDPs received a surface silica/glass infiltration treatment before the sintering process...
January 21, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28117522/versatility-of-pyrylium-salt-vinyl-ether-initiating-system-for-epoxide-dual-cure-polymerization-kick-starting-effect-of-the-coinitiator
#11
Maxime Lecompère, Xavier Allonas, David Maréchal, Adrien Criqui
Pyrylium salts combined with vinyl ethers are shown to act as new versatile dual-cure initiating systems for both photochemical and thermal initiation of oxirane monomers. The combination of both possibilities allows the curing of thick samples through photoinduced frontal polymerization. On the basis of quantum calculations and photochemical experiments, some clues are given about the reaction mechanisms involved. Interestingly, a sequential kick-starting effect is observed in the presence of vinyl ether enabling the curing of oxetane monomers...
January 24, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28088788/dual-syk-jak-inhibition-overcomes-ibrutinib-resistance-in-chronic-lymphocytic-leukemia-cerdulatinib-but-not-ibrutinib-induces-apoptosis-of-tumor-cells-protected-by-the-microenvironment
#12
Ailin Guo, Pin Lu, Greg Coffey, Pamela Conley, Anjali Pandey, Y Lynn Wang
Ibrutinib (BTK inhibitor) has generated remarkable responses in CLL. However, the drug, to a large extent, does not cause cell death directly and does not eradicate CLL malignant clones. Inability to eradicate CLL has fostered resistance generation. Once patients become resistant, they do poorly with a median survival of 3-4 months. Novel therapeutic strategies are needed to prevent resistance, improve treatment outcome and ultimately cure the disease. Herein, we explore dual targeting of the BCR and JAK-STAT pathways with a novel single agent, cerdulatinib, which selectively inhibits both SYK (a BCR component) and JAK kinases...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28069963/pathogen-boosted-adoptive-cell-transfer-immunotherapy-to-treat-solid-tumors
#13
Gang Xin, David M Schauder, Weiqing Jing, Aimin Jiang, Nikhil S Joshi, Bryon Johnson, Weiguo Cui
Because of insufficient migration and antitumor function of transferred T cells, especially inside the immunosuppressive tumor microenvironment (TME), the efficacy of adoptive cell transfer (ACT) is much curtailed in treating solid tumors. To overcome these challenges, we sought to reenergize ACT (ReACT) with a pathogen-based cancer vaccine. To bridge ACT with a pathogen, we genetically engineered tumor-specific CD8 T cells in vitro with a second T-cell receptor (TCR) that recognizes a bacterial antigen. We then transferred these dual-specific T cells in combination with intratumoral bacteria injection to treat solid tumors in mice...
January 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28059794/oxidative-stress-synaptic-dysfunction-and%C3%A2-alzheimer-s-disease
#14
Eric Tönnies, Eugenia Trushina
Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most AD cases are sporadic where age represents the greatest risk factor. Lack of understanding of the disease mechanism hinders the development of efficacious therapeutic approaches. The loss of synapses in the affected brain regions correlates best with cognitive impairment in AD patients and has been considered as the early mechanism that precedes neuronal loss. Oxidative stress has been recognized as a contributing factor in aging and in the progression of multiple neurodegenerative diseases including AD...
December 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28028417/a-twofold-comparison-between-dual-cure-resin-modified-cement-and-glass-ionomer-cement-for-orthodontic-band-cementation
#15
Hanaa El Attar, Omnia Elhiny, Ghada Salem, Ahmed Abdelrahman, Mazen Attia
AIM: To test the solubility of dual cure resin modified resin cement in a food simulating solution and the shear bond strength compared to conventional Glass ionomer cement. MATERIALS AND METHOD: The materials tested were self-adhesive dual cure resin modified cement and Glass Ionomer (GIC). Twenty Teflon moulds were divided into two groups of tens. The first group was injected and packed with the modified resin cement, the second group was packed with GIC. To test the solubility, each mould was weighed before and after being placed in an analytical reagent for 30 days...
December 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28000531/cytokines-and-metabolic-factors-regulate-tumoricidal-t-cell-function-during-cancer-immunotherapy
#16
Adam J Adler, Payal Mittal, Joseph M Ryan, Beiyan Zhou, Jeffrey S Wasser, Anthony T Vella
Recent advances in cancer biology and genetics have fostered precision therapies targeting tumor-specific attributes. Immune-based therapies that elicit cytolytic T cells (CTL) specific for tumor antigens can provide therapeutic benefit to cancer patients, however, cure rates are typically low. This largely results from immunosuppressive mechanisms operating within the tumor microenvironment, many of which inflict metabolic stresses upon CTL. Conversely, immunotherapies can mitigate specific metabolic stressors...
January 2017: Immunotherapy
https://www.readbyqxmd.com/read/27997540/il-7-receptor-mutations-and-steroid-resistance-in-pediatric-t-cell-acute-lymphoblastic-leukemia-a-genome-sequencing-study
#17
Yunlei Li, Jessica G C A M Buijs-Gladdines, Kirsten Canté-Barrett, Andrew P Stubbs, Eric M Vroegindeweij, Willem K Smits, Ronald van Marion, Winand N M Dinjens, Martin Horstmann, Roland P Kuiper, Rogier C Buijsman, Guido J R Zaman, Peter J van der Spek, Rob Pieters, Jules P P Meijerink
BACKGROUND: Pediatric acute lymphoblastic leukemia (ALL) is the most common childhood cancer and the leading cause of cancer-related mortality in children. T cell ALL (T-ALL) represents about 15% of pediatric ALL cases and is considered a high-risk disease. T-ALL is often associated with resistance to treatment, including steroids, which are currently the cornerstone for treating ALL; moreover, initial steroid response strongly predicts survival and cure. However, the cellular mechanisms underlying steroid resistance in T-ALL patients are poorly understood...
December 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27986884/beyond-rchop-a-blueprint-for-diffuse-large-b-cell-lymphoma-research
#18
REVIEW
Grzegorz S Nowakowski, Kristie A Blum, Brad S Kahl, Jonathan W Friedberg, Lawrence Baizer, Richard F Little, David G Maloney, Laurie H Sehn, Michael E Williams, Wyndham H Wilson, John P Leonard, Sonali M Smith
Diffuse large B cell lymphoma (DLBCL) comprises multiple molecular and biological subtypes, resulting in a broad range of clinical outcomes. With standard chemoimmunotherapy, there remains an unacceptably high treatment failure rate in certain DLBCL subsets: activated B cell (ABC) DLBCL, double-hit lymphoma defined by the dual translocation of MYC and BCL2, dual protein-expressing lymphomas defined by the overexpression of MYC and BCL2, and older patients and those with central nervous system involvement. The main research challenges for DLBCL are to accurately identify molecular subsets and to determine if specific chemotherapy platforms and targeted agents offer differential benefit...
December 2016: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27986363/efficacy-of-folfoxiri-plus-bevacizumab-in-liver-limited-metastatic-colorectal-cancer-a-pooled-analysis-of-clinical-studies-by-gruppo-oncologico-del-nord-ovest
#19
Chiara Cremolini, Mariaelena Casagrande, Fotios Loupakis, Giuseppe Aprile, Francesca Bergamo, Gianluca Masi, Roberto Moretto R, Filippo Pietrantonio, Federica Marmorino, Gemma Zucchelli, Gianluca Tomasello, Giuseppe Tonini, Giacomo Allegrini, Cristina Granetto, Laura Ferrari, Lucio Urbani, Umberto Cillo, Pierluigi Pilati, Elisa Sensi, Alessio Pellegrinelli, Massimo Milione, Gabriella Fontanini, Alfredo Falcone
Secondary resection is a chance of cure for a subgroup of metastatic colorectal cancer (mCRC) patients with unresectable liver-limited disease. Medical treatment has a dual goal: to induce tumour shrinkage and to prevent disease relapse. The aims of the present analysis were to assess the efficacy of FOLFOXIRI plus bevacizumab in this setting, and to investigate whether this regimen could revert the poor prognosis of high-risk patients defined by clinical and molecular factors. We performed a pooled analysis of patients with unresectable and liver-limited mCRC, treated with first-line FOLFOXIRI plus bevacizumab in three prospective clinical trials by Gruppo Oncologico del Nord Ovest...
December 13, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27982188/tensile-strength-of-resin-cements-used-with-base-metals-in-a-simulating-passive-cementation-technique-for-implant-supported-prostheses
#20
Hilmo Barreto Leite Falcão, Ricardo Faria Ribeiro, Raphael Freitas de Souza, Ana Paula Macedo, Rossana Pereira de Almeida
The aim of this study was to analyze the tensile strength of two different resin cements used in passive cementation technique for implant-supported prosthesis. Ninety-six plastic cylinders were waxed in standardized forms, cast in commercially pure titanium, nickel-chromium and nickel-chromium-titanium alloys. Specimens were cemented on titanium cylinders using self-adhesive resin cement or conventional dual-cured resin cement. Specimens were divided in 12 groups (n=8) in accordance to metal, cement and ageing process...
October 2016: Brazilian Dental Journal
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