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https://www.readbyqxmd.com/read/28644739/treatment-of-hepatitis-c-with-new-fixed-dose-combinations
#1
Vicente Soriano
The advent of oral direct-acting antivirals (DAA) has revolutionized the hepatitis C virus (HCV) therapeutic landscape providing cure rates over 90%. However, a subset of patients remains at higher risk for treatment failure, including those infected with: i) genotype 3 and cirrhosis; ii) resistance-associated substitutions (RAS) occurring either as natural polymorphisms or selected after prior DAA failure; and iii) poor drug adherence associated with social disabilities (homeless, psychiatric illnesses, injection drug use, alcoholism, etc...
June 23, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28644564/methacrylate-based-root-canal-sealer-containing-chlorexidine-and-%C3%AE-tricalcium-phosphate
#2
Fabrício Mezzomo Collares, Vicente Castelo Branco Leitune, Fernando Freitas Portella, Paula Dapper Santos, Gabriela de Souza Balbinot, Luís Alberto Dos Santos, Clarissa Cavalcanti Fatturi Parolo, Susana Maria Werner Samuel
The aim of this study was to develop and to characterize a methacrylate-based root canal sealer containing chlorhexidine (CHX) and α-tricalcium phosphate (α-TCP). Experimental dual cure methacrylate-based sealer was produced containing 0, 2.5, or 5 wt% of CHX and 0, 25, or 50 wt% of α-TCP. Experimental sealers were evaluated based on flow, film thickness, radiopacity, degree of conversion (DC), degradation in water, pH and antibacterial activity. Flow ranged from 15.09 ± 0.11 to 17.47 ± 0.42 mm...
June 23, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28642922/universal-cements-dual-activated-and-chemically-activated
#3
Eliane de Lima, Ricardo Santos, Márcia Durão, Armiliana Nascimento, Rodivan Braz
Objective: The aim of the present study was to assess the bond strength of universal cements cured either dually or chemically only. Methods: Three cements were assessed using different types of application: dual activated (DA) or chemically activated (CA). In total 80 dentin blocks were used, obtained through the enamel wear of the lingual and buccal surfaces of bovine incisors. Standard cone-shaped cavity preparations were created using diamond burs. Subsequently, indirect restoration blocks were designed with Filtek Z350 (3M ESPE) composite resin...
December 2016: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/28605612/influence-of-different-curing-modes-on-polymerization-behavior-and-mechanical-properties-of-dual-cured-provisional-resins
#4
S Shibasaki, T Takamizawa, T Suzuki, K Nojiri, A Tsujimoto, W W Barkmeier, M A Latta, M Miyazaki
This study determined the influence of curing mode on polymerization behavior and mechanical properties of dual-cured provisional resins. Three dual-cured bisacryl-based provisional resins were used: Tempsmart (TS; GC Corp), Luxatemp Automix Solar (LX; DMG Chemisch Pharmazeutishe Fabrik GmbH), and Integrity Multi·Cure (IG; Dentsply Caulk). A self-cured bisacryl-based provisional resin, Protemp Plus (PP; 3M ESPE) and a conventional poly(methyl methacrylate) (PMMA) provisional resin, Unifast III (UF; GC Corp) were used as controls...
June 12, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28599597/simultaneous-knockout-of-i-cxcr4-i-and-i-ccr5-i-genes-in-cd4-t-cells-via-crispr-cas9-confers-resistance-to-both-x4-and-r5-tropic-hiv-1-infection
#5
Songlin Yu, Yongchao Yao, Hongkui Xiao, Jiaojiao Li, Quan Liu, Yijun Yang, Dickson Adah, Junnan Lu, Siting Zhao, Li Qin, Xiaoping Chen
Previous research has proven that disruption of either <i>CCR5</i> or <i>CXCR4</i> gene confers resistance to R5-tropic or X4-tropic HIV-1 infection, respectively. However, the urgent need to ablate both of the coreceptors in individual post-thymic CD4+ T cells for dual protection remains. Here, we have ablated the <i>CCR5</i> and <i>CXCR4</i> genes in human CD4+ cell lines and primary CD4+ T cells, simultaneously, using CRISPR/Cas9, a well-developed, highly efficient genetic engineering tool...
June 9, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28597006/effect-of-final-irrigation-protocol-and-etching-mode-on-bond-strength-of-a-multimode-adhesive-in-the-root-canal
#6
Kerstin Bitter, Luise Polster, Haitham Askar, Manja von Stein-Lausnitz, Guido Sterzenbach
PURPOSE: To analyze the effects of ethanol for final post space irrigation and etching mode on the bond strength of fiber posts luted with a mild multimode adhesive (pH 2.3) as compared with a reference group using a self-adhesive resin cement (SAR). MATERIALS AND METHODS: Human anterior teeth were endodontically treated. After post space preparation, the root canals were irrigated using 1% sodium hypochlorite (NaOCl) applied with passive ultrasonic irrigation, followed by either distilled water (control) or distilled water and ethanol 99% as final post space irrigation...
June 8, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28591464/risk-of-low-bone-mineral-density-in-testicular-germ-cell-cancer-survivors-association-with-hypogonadism-and-treatment-modality
#7
S Isaksson, K Bogefors, K Åkesson, L Egund, J Bobjer, I Leijonhufvud, A Giwercman
The cure rate of testicular cancer exceeds 95%, but testicular cancer survivors (TCS) are at increased risk of hypogonadism (HG). It has been suggested that TCS have reduced bone mineral density (BMD), but it is unclear whether this is related to HG or a direct effect of cancer therapy. The aim of this study was to evaluate whether TCS have decreased BMD, and if BMD is related to HG and/or the cancer treatment given. We investigated 91 TCS (mean age at diagnosis: 31 years; mean 9.3 years follow-up) and equal number of age matched controls (mean age at inclusion 40...
June 7, 2017: Andrology
https://www.readbyqxmd.com/read/28584155/capsid-assembly-modulators-have-a-dual-mechanism-of-action-in-primary-human-hepatocytes-infected-with-hepatitis-b-virus
#8
Jan Martin Berke, Pascale Dehertogh, Karen Vergauwen, Ellen van Damme, Wendy Mostmans, Koen Vandyck, Frederik Pauwels
Hepatitis B Virus (HBV) capsid assembly is a critical step in the propagation of the virus mediated by the core protein. Due to its multiple functions in the viral life cycle, core became an attractive target for new antiviral therapies. Capsid assembly modulators (CAMs) accelerate the kinetics of capsid assembly and prevent encapsidation of the polymerase-pregenomic RNA (pol-pgRNA) complex thereby blocking viral replication. CAM JNJ-632 is a novel and potent inhibitor of HBV replication in vitro across genotypes A-D...
June 5, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28581634/no-one-size-fits-all-shortening-duration-of-therapy-with-direct-acting-antivirals-for-hepatitis-c-genotype-1-infection
#9
Omar El Sherif, Nezam Afhdal, Michael Curry
The advent of shorter duration, highly effective and well tolerated interferon-free therapy now provides an opportunity for virtually all HCV infected individuals to be cured. However, there continues to be a need to simplify and shorten treatment duration. Shortening therapy to 8 weeks with sofosbuvir and ledipasvir can be considered in treatment patients with HCV genotype 1 infection and low baseline viral load. A number of other 8 week dual and triple therapy direct acting antiviral (DAA) regimens are in advanced clinical development...
June 5, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28580462/does-tack-curing-luting-cements-affect-the-final-cure
#10
Daniel Stegall, Daranee Tantbirojn, Jorge Perdigão, Antheunis Versluis
PURPOSE: Short initial light curing or "tack curing" is used to create a semi-gel state in luting cements for easier excess material cleanup. The effect of tack curing on the final cure of luting cements was measured in terms of hardness. MATERIALS AND METHODS: Three cement types were tested: two dual-curing composite cements (RelyX Unicem 2; Maxcem Elite); three light-curing veneer cements (Choice 2; Variolink Esthetic LC; RelyX Veneer); and two self-curing resin-modified glass-ionomer (RMGI) luting cements (RelyX Luting Plus; Nexus RMGI)...
June 2, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28577408/dendrimer-functionalized-electrospun-nanofibres-as-dual-action-water-treatment-membranes
#11
Georgiana Amariei, Javier Santiago-Morales, Karina Boltes, Pedro Letón, Isabel Iriepa, Ignacio Moraleda, Amadeo R Fernández-Alba, Roberto Rosal
This work reports the preparation of composite electrospun membranes combining antimicrobial action with the capacity of retaining low-molecular weight non-polar pollutants. The membranes were electrospun blends of polyvinyl alcohol (PVA) and poly(acrylic acid) (PAA) stabilized using heat curing. The membranes were functionalized by grafting amino-terminated poly(amidoamine) (PAMAM) G3 dendrimers. The antimicrobial effect was assessed using strains of Escherichia coli and Staphylococcus aureus by tracking their capacity to form new colonies and their metabolic impairment upon contact with membranes...
May 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28574112/evaluation-of-color-changes-of-dental-luting-materials-in-food-colorant-solutions
#12
Canan Akay, Merve Ç Tanış
BACKGROUND: The purpose of this study was to compare the color stability and water absorption of 3 commercially available resin cements in vitro by storing them in 0.15% erythrosine, dark brown and sunset yellow for 30 days. METHODS: 2 self-adhesive resin cement and 1 dual/light curing, resin-based dental luting material were evaluated (total 120 samples). The CIE L, a, b of 10 mm diameter-2.0 mm height disk shaped samples was measured using a spectrophotometer for color stability on a white background, 10 mm diameter-1...
May 24, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28571263/the-effect-of-accelerated-aging-on-the-colour-stability-of-composite-resin-luting-cements-using-different-bonding-techniques
#13
Satheesh B Haralur, Mohammed Alfaifi, Abdulmajeed Almuaddi, Mazen Al-Yazeedi, Abdulmajeed Al-Ahmari
INTRODUCTION: The main criterion of successful aesthetic restoration is to match the colour of the adjacent teeth. Porcelain laminate veneer is widely practiced indirect restoration in the contemporary aesthetic dentistry. The underlying luting cement colour influences the final outcome of the thin, translucent veneer shade. Hence, colour stability of luting cement is important criteria during their selection. AIM: The objective of the study was to assess the colour stability of the different dentin bonding techniques in composite resin luting cements...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28569446/the-effect-of-lithium-disilicate-opacity-on-polymerization-of-a-dual-cured-resin-cement
#14
Dylton da Costa Neto, Jefferson Pereira, Saulo Pamato, Accácio do Valle
The aim of this study was to evaluate the influence of different levels of opacity of the lithium disilicate framework upon polymerization of dual-cured resin cement. Four ceramic discs were used, one for each opacity framework covered by their respective ceramic veneering, and a cement group without a ceramic cover. The degree of conversion for each resin cement was estimated using the Knoop microhardness test. The group with the highest opacity showed the lowest hardness score at baseline. The study concluded that the opacity level of lithium disilicate framework could influence the degree of polymerization of a dual-cured resin cement...
March 2017: European Journal of Prosthodontics and Restorative Dentistry
https://www.readbyqxmd.com/read/28566898/antimicrobial-susceptibility-testing-before-first-line-treatment-for-helicobacter-pylori-infection-in-patients-with-dual-or-triple-antibiotic-resistance
#15
Angel Cosme, Milagrosa Montes, Begoña Ibarra, Esther Tamayo, Horacio Alonso, Usua Mendarte, Jacobo Lizasoan, Marta Herreros-Villanueva, Luis Bujanda
AIM: To evaluate the efficacy of antimicrobial susceptibility-guided therapy before first-line treatment for infection in patients with dual or triple antibiotic resistance. METHODS: A total of 1034 patients infected by Helicobacter pylori (H. pylori) during 2013-2014 were tested for antimicrobial susceptibility. 157 of 1034 (15%) patients showed resistance to two (127/1034; 12%) and to three (30/1034; 3%) antibiotics. Sixty-eight patients with dual H. pylori-resistance (clarithromycin, metronidazole or levofloxacin) were treated for 10 d with triple therapies: OAL (omeprazole 20 mg b...
May 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28539069/real-world-challenges-for-hepatitis-c-virus-medications-a-critical-overview
#16
Imran Shahid, Waleed Hassan AlMalki, Sajida Hassan, Muhammad Hassan Hafeez
From 2010, the landscape of hepatitis C therapeutics has been changed rapidly, and today we are standing at a cusp of a pharmacological revolution where highly effective and interferon (IFN)-free direct acting antivirals (DAAs) are already on the market. Such treatment paradigms attain 90-95% sustained virologic response (SVR; undetectable viral load at week 12 or 24 at the end of therapy) rates in treated individuals compared to 50-70% with treatment completion of dual-therapy-pegylated interferon (PEG-IFN) and ribavirin (RBV)...
May 25, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28530207/fabrication-of-biomimetic-bone-grafts-with-multi-material-3d-printing
#17
Nicholas Sears, Prachi Dhavalikar, Michael Whitely, Elizabeth Cosgriff-Hernandez
Extrusion deposition is a versatile method for the 3D printing of biomaterials such as hydrogels, ceramics, and suspensions. Recently, a new class of emulsion inks were developed that can be used to create tunable, hierarchically porous materials with a cure-on-dispense method. Propylene fumarate dimethacrylate (PFDMA) was selected to fabricate bone grafts using this technology due to its established biocompatibility, osteoconductivity, and good compressive properties. Scaffolds fabricated from PFDMA emulsion inks displayed compressive modulus and yield strength of approximately 15 and 1 MPa, respectively...
May 22, 2017: Biofabrication
https://www.readbyqxmd.com/read/28527844/evaluation-of-various-pretreatments-to-fiber-post-on-the-push-out-bond-strength-of-root-canal-dentin
#18
Ömer Kırmalı, Özlem Üstün, Alper Kapdan, Alper Kuştarcı
INTRODUCTION: The aim of this in vitro study was to compare the effect of different pretreatments (fiber post) with the laser-activated irrigation (LAI) technique (for removal of the smear layer) on root canal dentin in terms of push-out bond strength (PBS) in a fiber post. METHODS: Fifty freshly extracted mandibular single-rooted premolars were prepared, and LAI was applied to all roots (17% EDTA was 5 mL for 120 seconds with an erbium, chromium:yttrium-scandium-gallium-garnet laser [0...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28527531/titanium-dioxide-nanotubes-addition-to-self-adhesive-resin-cement-effect-on-physical-and-biological-properties
#19
Carla M Ramos-Tonello, Paulo N Lisboa-Filho, Larisa B Arruda, Cintia K Tokuhara, Rodrigo C Oliveira, Adilson Y Furuse, José H Rubo, Ana Flávia S Borges
OBJECTIVES: This study has investigated the influence of Titanium dioxide nanotubes (TiO2-nt) addition to self-adhesive resin cement on the degree of conversion, water sorption, and water solubility, mechanical and biological properties. METHODS: A commercially available auto-adhesive resin cement (RelyX U200™, 3M ESPE) was reinforced with varying amounts of nanotubes (0.3, 0.6, 0.9wt%) and evaluated at different curing modes (self- and dual cure). The DC in different times (3, 6, 9, 12 and 15min), water sorption (Ws) and solubility (Sl), 3-point flexural strength (σf), elastic modulus (E), Knoop microhardness (H) and viability of NIH/3T3 fibroblasts were performed to characterize the resin cement...
May 17, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28522192/overcoming-photodynamic-resistance-and-tumor-targeting-dual-therapy-mediated-by-indocyanine-green-conjugated-gold-nanospheres
#20
Wei Li, Xiaomeng Guo, Fenfen Kong, Hanbo Zhang, Lihua Luo, Qingpo Li, Chunqi Zhu, Jie Yang, Yongzhong Du, Jian You
Photodynamic therapy (PDT) and photothermal therapy (PTT) have captured much attention due to the great potential to cure malignant tumor. Nevertheless, photodynamic resistance of cancer cells has limited the further efficacy of PDT. Unfortunately, the resistance mechanism and efforts to overcome the resistance still have been rarely reported so far. Here, we report a nanosystem with specific tumor targeting for combined PDT and PTT mediated by near-infrared (NIR) light, which was established by covalently conjugating indocyanine green (ICG) and TNYL peptide onto the surface of hollow gold nanospheres (HAuNS)...
May 15, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
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