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https://www.readbyqxmd.com/read/27917405/efficacy-and-safety-of-3-week-response-guided-triple-direct-acting-antiviral-therapy-for-chronic-hepatitis-c-infection-a-phase-2-open-label-proof-of-concept-study
#1
George Lau, Yves Benhamou, Guofeng Chen, Jin Li, Qing Shao, Dong Ji, Fan Li, Bing Li, Jialiang Liu, Jinlin Hou, Jian Sun, Cheng Wang, Jing Chen, Vanessa Wu, April Wong, Chris L P Wong, Stella T Y Tsang, Yudong Wang, Leda Bassit, Sijia Tao, Yong Jiang, Hui-Mien Hsiao, Ruian Ke, Alan S Perelson, Raymond F Schinazi
BACKGROUND: To shorten the course of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, we examined the antiviral efficacy and safety of 3 weeks of response-guided therapy with an NS3 protease inhibitor and dual NS5A inhibitor-NS5B nucleotide analogue. METHODS: In this open-label, phase 2a, single centre study, Chinese patients with chronic HCV genotype 1b infection without cirrhosis were randomly allocated by a computer program to one of three treatment groups (sofosbuvir, ledipasvir, and asunaprevir; sofosbuvir, daclatasvir, and simeprevir; or sofosbuvir, daclatasvir, and asunaprevir) until six patients in each group (1:1:1) achieved an ultrarapid virological response (plasma HCV RNA <500 IU/mL by day 2, measured by COBAS TaqMan HCV test, version 2...
October 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27898590/reactivation-of-simian-immunodeficiency-virus-reservoirs-in-the-brain-of-virally-suppressed-macaques
#2
Lucio Gama, Celina M Abreu, Erin N Shirk, Sarah L Price, Ming Li, Greg M Laird, Kelly A Metcalf Pate, Stephen W Wietgrefe, Shelby L O'Connor, Luiz Pianowski, Ashley T Haase, Carine Van Lint, Robert F Siliciano, Janice E Clements
OBJECTIVE: Resting CD4 T cells have been recognized as the major cell reservoir of latent HIV-1 during antiretroviral therapy (ART). Using an simian immunodeficiency virus (SIV)/macaque model for AIDS and HIV-related neurocognitive disorders we assessed the contribution of the brain to viral latency and reactivation. DESIGN: Pigtailed macaques were dual inoculated with SIVDeltaB670 and SIV17E-Fr and treated with an efficacious central nervous system-penetrant ART...
January 2, 2017: AIDS
https://www.readbyqxmd.com/read/27882021/compressive-strength-and-the-effect-of-duration-after-photo-activation-among-dual-cure-bulk-fill-composite-core-materials
#3
Fahad Alkhudhairy, Fahim Vohra
OBJECTIVES: To assess compressive strength and effect of duration after photoactivation on the compressive strength of different dual cure bulk fill composites. METHODS: Seventy-two disc shaped (4x10mm) specimens were prepared from three dual cure bulk fill materials, ZirconCore (ZC) (n=24), MulticCore Flow (MC) (n=24) and Luxacore Dual (LC) (n=24). Half of the specimens in each material were tested for failure loads after one hour [MC1 (n=12), LC1 (n=12) & ZC1 (n=12)] and the other half in 7 days [MC7 (n=12), LC7 (n=12), ZC7 (n=12)] from photo-polymerization using the universal testing machine at a cross-head speed of 0...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27881659/glycosyl-phosphatidylinositol-gpi-anchored-anti-hiv-scfv-efficiently-protect-cd4-t-cells-from-hiv-1-infection-and-deletion-in-hu-pbl-mice
#4
Chaobaihui Ye, Weiming Wang, Liang Cheng, Guangming Li, Michael Wen, Qi Wang, Qing Zhang, Dan Li, Paul Zhou, Lishan Su
: Despite the success in viral inhibition and CD4 T cell recovery by highly active antiretroviral treatment (HAART), HIV-1 is still not curable due to the persistence of HIV-1 reservoir during treatment. One patient with acute myeloid leukemia who received allogeneic hematopoietic stem cell transplantation from homozygous CCR5 Δ32 donor has had no detectable viremia for 9 years after HAART cessation. This case has inspired a field of HIV-1 cure research focusing on engineering HIV-1 resistance of permissive cells...
November 23, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27879042/high-antibiotic-resistance-of-helicobacter-pylori-and-its-effect-on-tailored-and-empiric-eradication-of-the-organism-in-lower-silesia-poland
#5
Stanisław Ferenc, Jan Gnus, Magdalena Kościelna, Małgorzata Kinda, Andriy Yarka, Luke Stewart, Wojciech Witkiewicz
BACKGROUND: At present, the resistance to antibiotics is considered the most important reason for Helicobacter pylori (HP) eradication failure. The aim of this study was to estimate the prevalence of antimicrobial resistance of HP strains and to evaluate tailored and empiric therapeutic regimens in patients with peptic ulcer disease associated with infection of this microorganism. MATERIALS AND METHODS: Between May 2011 and February 2013, 185 consecutive Polish patients with at least one positive Helicobacter pylori test (urease test, histopathologic examination, and/or culture) underwent eradication therapy...
November 23, 2016: Helicobacter
https://www.readbyqxmd.com/read/27871482/push-out-bond-strength-of-fiber-posts-to-intraradicular-dentin-using-multimode-adhesive-system
#6
Siavash Savadi Oskoee, Mahmoud Bahari, Soodabeh Kimyai, Saeed Asgary, Katayoun Katebi
INTRODUCTION: Because there is little information about bond strength of fiber posts cemented with a universal adhesive system (UAS) with different resin cements, the aim of this study was to compare the effect of different bonding strategies in the application of UASs on push-out bond strength of fiber posts to intraradicular dentin. METHODS: Seventy-two single-rooted teeth were randomly divided into 6 groups: self-adhesive resin cement (SAC), dual-cure resin cement (DCC), UAS in the etch-and-rinse (E&R) mode and SAC (E&R + SAC), UAS in the self-etch (SE) mode and SAC (SE + SAC), UAS in the E&R mode and DCC (E&R + DCC), and UAS in the SE mode and DCC (SE + DCC)...
December 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27847748/effects-of-radiant-exposure-and-wavelength-spectrum-of-light-curing-units-on-chemical-and-physical-properties-of-resin-cements
#7
Adriano Fonseca Lima, Stephanie Ellen Ferreira Formaggio, Lígia França Aires Zambelli, Alan Rodrigo Muniz Palialol, Giselle Maria Marchi, Cintia Helena Coury Saraceni, Marcelo Tavares de Oliveira
OBJECTIVES: In this study, we evaluated the influence of different radiant exposures provided by single-peak and polywave light-curing units (LCUs) on the degree of conversion (DC) and the mechanical properties of resin cements. MATERIALS AND METHODS: Six experimental groups were established for each cement (RelyX ARC, 3M ESPE; LuxaCore Dual, Ivoclar Vivadent; Variolink, DMG), according to the different radiant exposures (5, 10, and 20 J/cm(2)) and two LCUs (single-peak and polywave)...
November 2016: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/27843249/in-vitro-evaluation-of-stainless-steel-crowns-cemented-with-resin-modified-glass-ionomer-and-two-new-self-adhesive-resin-cements
#8
REVIEW
Sidhant Pathak, K K Shashibhushan, P Poornima, Vv Subba Reddy
AIMS: To assess and compare the retentive strength of two dual-polymerized self-adhesive resin cements (RelyX U200, 3M ESPE & SmartCem2, Dentsply Caulk) and a resin-modified glass ionomer cement (RMGIC; RelyX Luting 2, 3M ESPE) on stainless steel crown (SSC). MATERIALS AND METHODS: Thirty extracted teeth were mounted on cold cured acrylic resin blocks exposing the crown till the cemento-enamel junction. Pretrimmed, precontoured SSC was selected for a particular tooth...
July 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27837106/cutting-edge-t-regulatory-cell-depletion-reactivates-latent-simian-immunodeficiency-virus-siv-in-controller-macaques-while-boosting-siv-specific-t-lymphocytes
#9
Tianyu He, Egidio Brocca-Cofano, Benjamin B Policicchio, Ranjit Sivanandham, Rajeev Gautam, Kevin D Raehtz, Cuiling Xu, Ivona Pandrea, Cristian Apetrei
T regulatory cells (Tregs) are critical in shaping the latent HIV/SIV reservoir, as they are preferentially infected, reverse CD4(+) T cell activation status, and suppress CTL responses. To reactivate latent virus and boost cell-mediated immune responses, we performed in vivo Treg depletion with Ontak (denileukin diftitox) in two SIVsab-infected controller macaques. Ontak induced significant (>75%) Treg depletion and major CD4(+) T cell activation, and only minimally depleted CD8(+) T cells. The overall ability of Tregs to control immune responses was significantly impaired despite their incomplete depletion, resulting in both reactivation of latent virus (virus rebound to 10(3) viral RNA copies/ml plasma in the absence of antiretroviral therapy) and a significant boost of SIV-specific CD8(+) T cell frequency, with rapid clearance of reactivated virus...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27832792/gout-will-the-king-of-diseases-be-the-first-rheumatic-disease-to-be-cured
#10
EDITORIAL
Jasvinder A Singh
Gout is the most common inflammatory arthritis in adults in the Western world. Characterized by hyperuricemia and the effects of acute and chronic inflammation in joints and bursa, gout leads to an agonizing, chronically painful arthritis. Arthritis can also be accompanied by urate nephropathy and subcutaneous urate deposits (tophi). Exciting new developments in the last decade have brought back the focus on this interesting, crystal-induced chronic inflammatory condition. New insights include the role of NALP3 inflammasome-induced inflammation in acute gout, the characterization of diagnostic signs on ultrasound and dual-energy computed tomography imaging modalities, the recognition of target serum urate less than 6 mg/day as the goal for urate-lowering therapies, and evidence-based treatment guidelines...
November 11, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27830145/in-vitro-comparative-analysis-of-fracture-resistance-in-inlay-restoration-prepared-with-cad-cam-and-different-systems-in-the-primary-teeth
#11
Huseyin Simsek, Sera Derelioglu
Objective. The aim of this study was to compare to fracture resistance test of inlay restorations prepared using direct inlay technique (Gradia® Direct Composite) and Indirect Restoration System® (Gradia Indirect Composite) and CAD/CAD system (Vita Enamic® Block). Study Design. 48 noncarious extracted maxillary second primary molars were randomly divided into 4 groups with 12 in each group. All the teeth were prepared based on inlay class II preparations except for the control group. Other groups were restored with Gradia Direct Composite, Gradia Indirect Composite, and Vita Enamic Block, respectively...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27814693/outcomes-of-tb-treatment-in-hiv-co-infected-tb-patients-in-ethiopia-a-cross-sectional-analytic-study
#12
Solomon Ahmed Ali, Thandisizwe R Mavundla, Ribka Fantu, Tadesse Awoke
BACKGROUND: TB and HIV are the most prevalent communicable diseases of major public health importance in the populations of sub-Saharan African countries, and an estimated 30 % of HIV infected persons have dual infection with TB. TB is the leading cause of death in HIV infected individuals, and HIV co-infected TB patients have multiple individual, disease specific and treatment related factors that can adversely affect their treatment outcomes. There is lack of evidence on the individual patient outcomes of HIV co-infected TB patients who receive anti-TB treatment...
November 4, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27811443/measuring-the-resistance-of-different-substructure-materials-by-sticking-them-to-dentine-with-two-different-resin-cements-in-vitro
#13
V Eratilla, A D Yildiz, S Guven, E A Eratilla, T Karaman, S Aguloglu, E Sumer
INTRODUCTION: The resistance of three different substructure materials - metal (Cr-Co), zirconium (Zr), and ceramics (IPS Empress II) - was measured by sticking them to dentine with two different resin cements, a dual-cure resin cement (Panavia F 2.0 Light) and a self-adhesive resin cement (BisCem). MATERIALS AND METHODS: In an in vitro study, 72 central upper front teeth were selected with no decay or apparent breakage and with complete development, removed for periodontal reasons...
November 2016: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27810592/discovery-of-novel-3-hydroxypicolinamides-as-selective-inhibitors-of%C3%A2-hiv-1-integrase-ledgf-p75-interaction
#14
Feng-Hua Zhang, Bikash Debnath, Zhong-Liang Xu, Liu-Meng Yang, Li-Rui Song, Yong-Tang Zheng, Nouri Neamati, Ya-Qiu Long
Currently, three HIV-1 integrase (IN) active site-directed inhibitors are in clinical use for the treatment of HIV infection. However, emergence of drug resistance mutations have limited the promise of a long-term cure. As an alternative, allosteric inhibition of IN activity has drawn great attention and several of such inhibitors are under early stage clinical development. Specifically, inhibitors of IN and the cellular cofactor LEDGF/p75 remarkably diminish proviral integration in cells and deliver a potent reduction in viral replicative capacity...
January 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27809863/correlation-between-flexural-and-indirect-tensile-strength-of-resin-composite-cements
#15
Gianluca Cassina, Jens Fischer, Nadja Rohr
BACKGROUND: To evaluate a potential correlation between flexural strength and indirect tensile strength in assessing the mechanical strength of resin composite cements. METHODS: Flexural strength (n = 5) and indirect tensile strength (n = 5) of 7 resin composite cements (RelyX Unicem 2 Automix [RXU], Panavia SA [PSA], Clearfil SA [CSA], Panavia F2.0 [PF2], Multilink Implant [MLI], DuoCem [DCM], Panavia 21 [P21]) were determined. Specimens were either auto-polymerized or dual-cured (except P21) and stored in water at 37 °C for 1 day prior to measurement...
November 4, 2016: Head & Face Medicine
https://www.readbyqxmd.com/read/27758699/design-synthesis-and-molecular-docking-studies-of-new-potential-piperazine-derivatives-as-cognition-enhancers
#16
Chhanda C Danta, Poonam Piplani
BACKGROUND: In 2016, the statistical reports stated that Alzheimer is not just memory loss but it kills and has become the 6th leading cause of death. The number of dementia patients is increasing rapidly and expected to rise to 131.5 million by 2050. Still there is not a drug candidate that can cure the cognitive deficits completely. OBJECTIVE: Series of novel piperazine derivatives have been designed, synthesized and evaluated for cognition enhancing activity...
October 14, 2016: Central Nervous System Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27749069/highly-effective-dual-function-near-infrared-nir-photosensitizer-for-fluorescence-imaging-and-photodynamic-therapy-pdt-of-cancer
#17
Nayan Patel, Paula Pera, Penny Joshi, Mykhaylo Dukh, Walter A Tabaczynski, Kevin E Siters, Mark Kryman, Ravindra R Cheruku, Farukh Durrani, Joseph R Missert, Ramona Watson, Tymish Y Ohulchanskyy, Erin C Tracy, Heinz Baumann, Ravindra K Pandey
We report herein the synthesis and biological efficacy of near-infrared (NIR), bacteriochlorin analogues: 3-(1'-butyloxy)ethyl-3-deacetyl-bacteriopurpurin-18-N-butylimide methyl ester (3) and the corresponding carboxylic acid 10. In in vitro assays, compared to its methyl ester analogue 3, the corresponding carboxylic acid derivative 10 showed higher photosensitizing efficacy. However, due to drastically different pharmacokinetics in vivo, the PS 3 (HPLC purity >99%) showed higher tumor uptake and long-term tumor cure than 10 (HPLC purity >96...
October 31, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27741116/assessment-of-cost-of-innovation-versus-the-value-of-health-gains-associated-with-treatment-of-chronic-hepatitis-c-in-the-united-states-the-quality-adjusted-cost-of-care
#18
Zobair M Younossi, Haesuk Park, Douglas Dieterich, Sammy Saab, Aijaz Ahmed, Stuart C Gordon
BACKGROUND: New direct-acting antiviral (DAA) therapy has dramatically increased cure rates for patients infected with hepatitis C virus (HCV), but has also substantially raised treatment costs. AIM: The aim of this analysis was to evaluate the therapeutic benefit and net costs (i.e. efficiency frontier) and the quality-adjusted cost of care associated with the evolution of treatment regimens for patients with HCV genotype 1 in the United States. DESIGN: A decision-analytic Markov model...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27738633/shear-bond-strength-of-three-orthodontic-bonding-systems-on-enamel-and-restorative-materials
#19
Andreas Hellak, Jennifer Ebeling, Michael Schauseil, Steffen Stein, Matthias Roggendorf, Heike Korbmacher-Steiner
Objective. The aim of this in vitro study was to determine the shear bond strength (SBS) and adhesive remnant index (ARI) score of two self-etching no-mix adhesives (iBond™ and Scotchbond™) on different prosthetic surfaces and enamel, in comparison with the commonly used total etch system Transbond XT™. Materials and Methods. A total of 270 surfaces (1 enamel and 8 restorative surfaces, n = 30) were randomly divided into three adhesive groups. In group 1 (control) brackets were bonded with Transbond XT primer...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27735878/mid-infrared-photoacoustic-detection-of-glucose-in-human-skin-towards-non-invasive-diagnostics
#20
Jonas Kottmann, Julien M Rey, Markus W Sigrist
Diabetes mellitus is a widespread metabolic disease without cure. Great efforts are being made to develop a non-invasive monitoring of the blood glucose level. Various attempts have been made, including a number of non-optical approaches as well as optical techniques involving visible, near- and mid-infrared light. However, no true breakthrough has been achieved so far, i.e., there is no fully non-invasive monitoring device available. Here we present a new study based on mid-infrared spectroscopy and photoacoustic detection...
October 10, 2016: Sensors
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