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https://www.readbyqxmd.com/read/28415443/3-month-parenteral-plga-microsphere-formulations-of-risperidone-fabrication-characterization-and-neuropharmacological-assessments
#1
Sundeep Chaurasia, Kuchukuntla Mounika, Vasudha Bakshi, Vure Prasad
The study aims at formulation and characterization of three months parenteral risperidone loaded polymeric microspheres (p-RLPMs) as a sustained delivery system and established their in vitro and in vivo assessments. The p-RLPMs formulations were prepared by solvent extraction and diffusion method. The optimized p-RLPMs (batch RPLGA-1) formulation demonstrated favorable different physicochemical properties such as mean particle size (104±5.34μm), percent porosity (44.56±3.11%) and percent drug loading (38...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28411141/formulation-of-carbapenems-loaded-gold-nanoparticles-to-combat-multi-antibiotic-bacterial-resistance-in-vitro-antibacterial-study
#2
Mohamed A Shaker, Mona I Shaaban
Despite the fact that carbapenems (powerful β-lactams antibiotics) were able to fight serious infectious diseases, nowadays the spread of carbapenems-resistant bacteria is considered the main challenge in antibacterial therapy. In this study, we focused on evaluating the surface conjugation of carbapenems (imipenem and meropenem) with gold nanoparticles as a delivering strategy to specifically and safely maximize their therapeutic efficacy while destroying the developing resistance of the pathogens. Different particle size formulae (35, 70 and 200nm) were prepared by citrate reduction method...
April 11, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28409368/comparison-of-orvil%C3%A2-and-rpd-in-laparoscopic-total-gastrectomy-for-gastric-cancer
#3
Xi Li, Liang Hong, Dan Ding, Yaping Liu, Gengming Niu, Liang Li, Xin Wang, Xiaomei Li, Chongwei Ke
BACKGROUND: Laparoscopic total gastrectomy (LTG) is frequently performed for treating patients with gastric cancer; however, the absence of anastomotic techniques with greater superiority has impaired its popularization. We have compared two types of anastomotic techniques with regard to technical perspectives and clinical outcomes. METHODS: We reviewed 43 patients with gastric cancer who underwent LTG. Two types of anastomotic techniques have been applied after LTG-the trans-orally inserted anvil (OrVil™) and the reverse puncture device (RPD)...
April 13, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28406127/masticatory-efficiency-of-shortened-dental-arch-subjects-with-removable-partial-denture-a-comparative-study
#4
J O Omo, M A Sede, T A Esan
OBJECTIVE: The objective of this study was to compare the masticatory efficiency in subjects with shortened dental arch (SDA) before and after restoration with removable partial denture (RPD). MATERIALS AND METHODS: This was a prospective study carried out on 36 consecutive patients. The subjects were asked to chew 5 g of a measured portion of fresh raw carrot for 20 specified numbers of strokes. The raw carrot was recovered into a cup and strained through a standard mesh sieve of 5 mm by 1 mm, it was air dried for 30 min and weighed with FEM digital series weighing scale...
April 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28394833/optimizing-half-squat-post-activation-potential-load-in-squat-jump-training-for-eliciting-relative-maximal-power-in-ski-jumpers
#5
A Gołaś, M Wilk, P Statsny, A Maszczyk, K Pajerska, A Zajac
Training load manipulation in a single workout session can increase or decrease training effectiveness in terms of athlete's strength or power gains. In ski jumping the complex training that elicits maximal power gains may take advantage of the post activation potentiation mechanism (PAP). The aim of research was to evaluate the changes in rate of force development (RFD), rate of power development (RPD) and jump height during a complex training session consisted of the barbell half squat (Sq) as an conditioning exercise with loads ranged between 60-100% of 1 repetition maximum (1RM), followed by a body weight squat jump (SqJ) as a performance task...
April 7, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28389024/accuracy-of-a-digital-removable-partial-denture-fabricated-by-casting-a-rapid-prototyped-pattern-a-clinical-study
#6
Jong-Won Lee, Ji-Man Park, Eun-Jin Park, Seong-Joo Heo, Jai-Young Koak, Seong-Kyun Kim
STATEMENT OF PROBLEM: A limited number of clinical studies have evaluated the accuracy of a digitally generated removable partial denture (RPD) intraorally. An analysis of the accuracy of the digital RPD on a larger number of participants was needed. PURPOSE: The purpose of this clinical study was to analyze the accuracy of digital RPDs by using the replica technique. MATERIAL AND METHODS: The fit accuracy of digital RPDs fabricated using electronic surveying was analyzed by fabricating replicas with silicone registration material and measuring with a stereomicroscope and image program...
April 4, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28388704/quantitative-analysis-of-the-ellipsoid-zone-intensity-in-phenotypic-variations-of-intermediate-age-related-macular-degeneration
#7
Thomas J Gin, Zhichao Wu, Sky K H Chew, Robyn H Guymer, Chi D Luu
Purpose: Reduction of the ellipsoid zone (EZ) intensity has been reported in eyes with age-related macular degeneration (AMD). This study determined whether overall EZ intensity, in retinal locations undisturbed by pathologic features, is associated with the presence of clinical features, which are known important phenotypic risk factors for disease progression, large drusen, reticular pseudodrusen (RPD), and pigmentary abnormalities. Methods: A horizontal B-scan through the foveola on spectral-domain optical coherence tomography (SD-OCT) was performed in both eyes of 75 participants with bilateral intermediate AMD and 10 age-similar control participants...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28386108/structural-insight-into-the-specific-dna-template-binding-to-dnag-primase-in-bacteria
#8
Yingqin Zhou, Hao Luo, Zhongchuan Liu, Mu Yang, Xiaoyun Pang, Fei Sun, Ganggang Wang
Bacterial primase initiates the repeated synthesis of short RNA primers that are extended by DNA polymerase to synthesize Okazaki fragments on the lagging strand at replication forks. It remains unclear how the enzyme recognizes specific initiation sites. In this study, the DnaG primase from Bacillus subtilis (BsuDnaG) was characterized and the crystal structure of the RNA polymerase domain (RPD) was determined. Structural comparisons revealed that the tethered zinc binding domain plays an important role in the interactions between primase and specific template sequence...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28365602/benefits-of-case-based-versus-traditional-lecture-based-instruction-in-a-preclinical-removable-prosthodontics-course
#9
COMPARATIVE STUDY
David B Samuelson, Kimon Divaris, Ingeborg J De Kok
This study compared the acceptability and relative effectiveness of case-based learning (CBL) versus traditional lecture-based (LB) instruction in a preclinical removable prosthodontics course in the University of North Carolina at Chapel Hill School of Dentistry DDS curriculum. The entire second-year class (N=82) comprised this crossover study's sample. Assessments of baseline comprehension and confidence in removable partial denture (RPD) treatment planning were conducted at the beginning of the course. Near the end of the course, half of the class received CBL and LB instruction in an RPD module in alternating sequence, with students serving as their own control group...
April 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28343666/removable-partial-dentures-the-clinical-need-for-innovation
#10
REVIEW
Stephen D Campbell, Lyndon Cooper, Helen Craddock, T Paul Hyde, Brian Nattress, Sue H Pavitt, David W Seymour
STATEMENT OF PROBLEM: The number of partially dentate adults is increasing, and many patients will require replacement of missing teeth. Although current treatment options also include fixed partial dentures and implants, removable partial dentures (RPDs) can have advantages and are widely used in clinical practice. However, a significant need exists to advance materials and fabrication technologies because of the unwanted health consequences associated with current RPDs. PURPOSE: The purpose of this review was to assess the current state of and future need for prosthetics such as RPDs for patients with partial edentulism, highlight areas of weakness, and outline possible solutions to issues that affect patient satisfaction and the use of RPDs...
March 23, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28340731/prediction-of-organic-carbon-and-total-nitrogen-contents-in-organic-wastes-and-their-composts-by-infrared-spectroscopy-and-partial-least-square-regression
#11
M Sisouane, M M Cascant, S Tahiri, S Garrigues, M El Krati, G El Kadiri Boutchich, M L Cervera, M de la Guardia
Middle and near infrared (MIR and NIR) were employed to determine organic carbon (OC) and total nitrogen (TN) in different soil organic amendments including wastes, composts and mixtures of composts and organic wastes. Prediction models based on partial least squares (PLS) regression from the spectra of untreated samples were built. Different spectra preprocessing strategies were adopted and the best number of latent variable was evaluated using leave-one-out cross-validation. Attenuated total reflectance (PLS-ATR-MIR) and diffuse reflectance (PLS-DR-NIR) models were built and evaluated from root mean square error of cross validation and prediction (RMSECV and RMSEP), coefficients of determination for prediction (R(2) pred) and residual predictive deviation (RPD)...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28317243/implant-supported-mandibular-removable-partial-dentures-functional-clinical-and-radiographical-parameters-in-relation-to-implant-position
#12
Charlotte Jensen, Caroline M Speksnijder, Gerry M Raghoebar, Wouter Kerdijk, Henny J A Meijer, Marco S Cune
BACKGROUND: Patients with a Kennedy class I situation often encounter problems with their removable partial denture (RPD). PURPOSE: To assess the functional benefits of implant support to RPDs, the clinical performance of the implants and teeth and to determine the most favorable implant position: the premolar (PM) or molar (M) region. MATERIALS AND METHODS: Thirty subjects received 2 PM and 2 M implants. A new RPD was made. Implant support was provided 3 months later...
March 20, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28290765/subjective-responses-to-interval-and-continuous-exercise-in-adults-with-exercise-induced-bronchoconstriction
#13
Carley O'Neill, Shilpa Dogra
BACKGROUND: Exercise triggers asthma symptoms among adults with exercise induced bronchoconstriction (EIBC). This may lead to lower physical activity levels among this population. The purpose of this study was to assess perceived exertion (RPE), perceived breathlessness (RPD), affect (FS), and physical activity enjoyment during and following an acute bout of high intensity interval exercise (HIIE), moderate intensity interval (MIIE) and moderate intensity continuous exercise (MICE) in adults with EIBC...
March 14, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28274480/use-of-intraoral-scanning-and-3-dimensional-printing-in-the-fabrication-of-a-removable-partial-denture-for-a-patient-with-limited-mouth-opening
#14
Jiang Wu, Yan Li, Yumei Zhang
BACKGROUND AND OVERVIEW: When treating patients with severely limited mouth openings, it is difficult for the dentist to obtain an impression and fabricate a removable partial denture (RPD) by using traditional methods. Intraoral scanning, computer-aided design, and 3-dimensional (3D) printing have provided alternative methods for fabricating dental prostheses. CASE DESCRIPTION: The authors present a case in which they aimed to improve the efficiency and quality of fabricating an RPD framework by integrating the technologies of intraoral scanning, computer-aided design, and 3D printing...
March 5, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28274442/development-of-predictive-models-for-total-phenolics-and-free-p-coumaric-acid-contents-in-barley-grain-by-near-infrared-spectroscopy
#15
Zhigang Han, Shengguan Cai, Xuelei Zhang, Qiufeng Qian, Yuqing Huang, Fei Dai, Guoping Zhang
Barley grains are rich in phenolic compounds, which are associated with reduced risk of chronic diseases. Development of barley cultivars with high phenolic acid content has become one of the main objectives in breeding programs. A rapid and accurate method for measuring phenolic compounds would be helpful for crop breeding. We developed predictive models for both total phenolics (TPC) and p-coumaric acid (PA), based on near-infrared spectroscopy (NIRS) analysis. Regressions of partial least squares (PLS) and least squares support vector machine (LS-SVM) were compared for improving the models, and Monte Carlo-Uninformative Variable Elimination (MC-UVE) was applied to select informative wavelengths...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28274077/palliative-care-with-attachment-hybrid-removable-prosthesis
#16
Gopi Naveen Chander
Abutment injury, unsatisfactory aesthetics and lesser retention exist with the cast partial denture. Though these constraints exist in the Removable Partial Denture (RPD) it is still widely used because of the simplicity in design, fabrication, economics and patient comfort. This clinical report describes a hybrid RPD technique which uses extra coronal attachment that reduces the limitations and provides better comfort for the patient.
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28273692/the-extent-and-scope-of-prosthodontic-practice-in-iowa
#17
Ronald L Ettinger, Zachary S Goettsche, Fang Qian
PURPOSE: The purpose of this questionnaire was to ask general dentists in private practice in the state of Iowa about the extent and scope of their prosthodontic practice. MATERIALS AND METHODS: A 22-item questionnaire was developed and tested on 5 general dentists. The Iowa Dental Association agreed to electronically distribute the survey to all general practice dentists in their database. After three rounds, a total of 289 responses were received from the 996 general dentists in the database...
March 8, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28271947/health-assessment-questionnaire-disability-index-haq-di-score-at-the-start-of-biological-disease-modifying-antirheumatic-drug-bdmard-therapy-is-associated-with-radiographic-progression-of-large-joint-damage-in-patients-with-rheumatoid-arthritis
#18
Arata Nakajima, Yasuchika Aoki, Keiichiro Terayama, Masato Sonobe, Hiroshi Takahashi, Masahiko Saito, Koichi Nakagawa
OBJECTIVES: Radiographic progression of damage (RPD) to large joints in patients with rheumatoid arthritis (RA) has not been fully studied. We previously demonstrated that Larsen grade of the large joints was associated with RPD of large joints in patients treated with biological disease-modifying anti-rheumatic drugs (bDMARDs); however, no factors associated with background characteristics of patients were identified. METHODS: A total of 400 large joints in the upper and lower extremities, including the shoulder, elbow, knee, and ankle, of 88 patients with RA treated with bDMARDs for 1-3 years were investigated...
March 8, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28270492/retinal-pigment-epithelial-features-indicative-of-neovascular-progression-in-age-related-macular-degeneration
#19
Philipp K Roberts, Bernhard Baumann, Ferdinand G Schlanitz, Stefan Sacu, Matthias Bolz, Michael Pircher, Michael Hagmann, Christoph K Hitzenberger, Ursula Schmidt-Erfurth
BACKGROUND/AIMS: To identify characteristic retinal pigment epithelium (RPE) changes in fellow eyes of patients with neovascular age-related macular degeneration (nAMD) using polarisation-sensitive optical coherence tomography (PS-OCT). METHODS: Thirty-one fellow eyes of 31 patients with unilateral nAMD were evaluated in this cohort study of a prospective interventional trial. PS-OCT as well as conventional imaging including spectral-domain (SD)-OCT and fluorescein angiography (FA) were performed using a standardised protocol...
March 7, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28265823/changes-in-reticular-pseudodrusen-area-in-eyes-that-progressed-from-early-to-late-age-related-macular-degeneration
#20
Patrick A Kaszubski, Tal Ben Ami, Céline Saade, Camellia Nabati, Vivek Kumar, Ana Rita Santos, Rufino Silva, Maria Luz Cachulo, José G Cunha-Vaz, R Theodore Smith
OBJECTIVE: This retrospective cohort study utilized 3 imaging modalities to analyze quantitatively reticular pseudodrusen (RPD) area changes in eyes that progressed from early to late age-related macular degeneration (AMD). METHODS: Subjects with AMD, unilateral choroidal neovascularization (CNV), and early AMD with RPD in the fellow eye (the study eye) were included. The study eyes underwent indocyanine green angiography (ICGA), near-infrared reflectance (NIR-R), and short-wavelength autofluorescence (AF) imaging of the macula at baseline and at follow-up...
March 7, 2017: International Ophthalmology
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